استخدم العكبر قديماً في الطب الشعبي لمعالجة العديد من الأمراض، مما جعله محوراً هاماً لبحث يتم فيه دعم ذلك الاستخدام الشعبي بنتائج علمية مثبتة. تم الكشف عن العديد من المركبات الطبيعة الفعالة حيوياً في تركيب العكبر، مما دفع الباحثين حول العالم إلى العمل لاستقصاء خواصه الكيميائية والحيوية، بالإضافة إلى تقديم براهين تؤكد نجاعته في تطبيقاته الطبية. في هذا البحث دُرست المكونات الكيميائية للعكبر السوري. جُمع العكبر من منطقة مصياف في الجزء الغربي من سورية. بدأ العمل بالاستخلاص بالايثانول ومن ثم تحليل الخلاصة باستخدام الاستشراب السائل الرفيع الإنجاز (HPLC) واالاستشراب الغازي المتصل بمقياس طيف الكتلة (GC/MS).
من المركبات الرئيسة التي جرى استعرافها في الخلاصة الايثانولية للعكبر السوري المنشأ: مركبات فينولية كالكريسين 1.8%، الجالينجين 0.3%، استربنزيل القهوة 0.65%، أكاسيتين 3.11%، الكيرستين 0.45%، بالإضافة الى مركبات عضوية أهمها حمض الإيزوبيماريك 24.88% ومشتق الأندروستان 1، 17-ثنائي ميثيل-17-هيدروكسي-3-أون 10.46%. أظهرت النتائج حين تعيين المحتوى الكلي للفينولات في العكبر السوري المدروس، أن محتوى الفينولات الكلية كان 299.31±0.21 مغ من حمض الغاليك لكل غرام من الخلاصة الجافة. جرى تقييم الفعالية الحيوية المضادة للأكسدة لخلاصة العكبر في المختبر من خلال اختبار DPPH. ولوحظ قدرته العالية على تعديل الجذر الحر وأن هذا التأثير يعتمد على تراكيز الخلاصة المطبقة من العكبر. أظهرت الدراسة غنى العكبر السوري بمحتواه الفينولي وأهميته كعامل طبيعي مضاد للأكسدة، مما يمكن أن يجعله مكوناً أساسياً لتعزيز صحة الإنسان والوقاية من الأمراض المتحرضة بالشدة التأكسدية كالسرطان، وأمراض القلب والشرايين وغيرها.
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