Simple, sensitive and accurate Spectrophotometric method for the determination of Sertraline hydrochloride in pure samples and tablets is presented. An ion pair complexation with bromocresol purple acidic dye was carried out. Sertraline hydrochloride was treated with reagent bromocresol purple in the presence of Clark and Lubes buffer at pH 2.0. The ion pair complex was extracted with chloroform and the absorbance was measured at 412 nm. Molar absorptivity was about 2.50 × 104 L cm1 mol1.The variables that affect development of color were investigated and the conditions were optimized. The proposed procedure was applicable to determine 2-14 μg/ml of Sertraline hydrochloride according to Beer’s law and the visual detection limit was 0.10 μg/ml. Correlation coefficient was 0.9993 which indicate good linearity. The stoichiometry of Sertraline hydrochloride – bromocresol purple complex was 1:1 as studied by Job’s method of continuous variation. The mean percentage recoveries ± SD were found to be 99.52 ± 0.59 and 100.45 ± 0.79 in pure form and tablets preparation respectively which indicate accurate and precise results. The validity of the method was checked by applying standard addition method; the mean percentage recovery was 99.76±0.60 this means there is no interferences from Excipients in tablets at 412 nm.