الخلفية: يتزايد عالمياً معدل انتشار المتلازمة الاستقلابية (MetS) ومضاعفاتها الرئيسة [النمط الثاني من الداء السكري (T2DM) والأمراض القلبية الوعائية (CVDs)]. ومع ذلك، لا يزال الجدل يتناول وجود تعريف دقيق موحد لتشخيص هذه المتلازمة ومساهمة المكونات المستبطنة لها. الغرض: الهدف الرئيس لهذه الدراسة هو تقديم معلومات واقعية عن بعض الواصمات الحيوية للبدانة ومقاومة الأنسولين والحالة الالتهابية والتي تترافق مع المتلازمة الاستقلابية والتي قد تساعد في الكشف المبكر عنها وتدبيرها في عينة من السوريين البالغين فوق الأربعين عاماً من العمر.
الطرائق: درسنا 159 بالغاً فوق سن الأربعين عاماً (79 أنثى و80 ذكراً)، كان بينهم 119 مصاباً بالنمط الثاني من الداء السكري (60 أنثى و59 ذكراً) و40 مشاركاً (19 أنثى و21 ذكراً) من الأسوياء ظاهرياً والمقاربين من حيث الجنس والعمر لمجموعة المرضى. كان 96 (54 أنثى و42 ذكراً) من مرضى السكري مصابين بالمتلازمة الاستقلابية، بينما كان تشخيص هذه المتلازمة سلبياً لدى 23 مصاباً بالنمط الثاني من الداء السكري (6 إناث و17 ذكراً) ولدى المشاركين الأسوياء جميعهم. قُيّمَت القياسات الأنثروبومترية والخاصة بمقاومة الأنسولين وحساسيته ومكونات البروفيل الشحمي والحالة الالتهابية كلها لدى المشاركين جميعهم باستخدام الطرائق المناسبة. تمت الدراسة الإحصائية باستخدام الإصدار 22.0 من برمجيات SPSS، وتم اعتماد قيمة P الأقل من 0.05 للدلالة على الأهمية الإحصائية في كل الاختبارات.
النتائج: كانت مستويات منسب كتلة الجسم BMI وقياس نموذج الاستتباب لمقاومة الأنسولين HOMA-IR ومنسب توليد الأنسولين IgI والكوليسترول خارج البروتينات الشحمية مرتفعة الكثافة Non-HDL-C والبروتين التفاعلي C (أو CRP) كلها مرتبطة بقوة بالمتلازمة الاستقلابية ومعايير تشخيصها ومضاعفاتها.
الاستنتاج: تشير نتائج الدراسة الحالية إلى أن الواصمات المدروسة يمكن أن تساعد في الكشف والتدبير المبكر عن المتلازمة الاستقلابية ومضاعفاتها المهددة للحياة، مما يسمح بالتدخلات الباكرة وإنقاص العبء الكبير الذي تفرضه هذه المتلازمة ومضاعفاتها على المرضى والمجتمعات والأنظمة الصحية.
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