تحضير تحاميل مهبلية من الفاردينافيل وتقييمها في المختبر

تحضير تحاميل مهبلية من الفاردينافيل وتقييمها في المختبر

2021-07-01 | المجلد السادس العدد السابع - المجلد السادس | مقالات بحثية
محمد أنس فيوم | جميلة حسيان

الملخص

يعد المهبل من الطرق الشائعة لإيصال الدواء الى الرحم مع تقليل للآثار الجانبية وزيادة التوافر الحيوي. والفاردينافيل هو نمط من مثبطات الفسفو دي استراز-5، بتوافر حيوي فموي حوالي 15% فقط. وبالتالي يعد إيتاء الدواء بالطريق المهبلي مثالياً لأدوية مثل الفاردينافيل.

الهدف من هذه الدراسة هو صياغة وتقييم تحاميل مهبلية من الفاردينافيل، لدراسة تأثير المضافات وبعض العوامل الفاعلة على السطح على معدل تحرر الدواء. حُضّرت تحاميل مهبلية يحتوي كل منها على 20 مغ من الفاردينافيل وحُددت خصائصها من اختلاف الوزن، تجانس المحتوى، القساوة، زمن التفتت. كما جرى أيضاً استقصاء وسط الذوبان في المختبر.


كلمات مفتاحية : الفاردينافيل، المهبل، المرور الكبدي الأول، تحاميل مهبلية، بولي ايثيلن غليكول PEG، بطانة الرحم الرقيقة
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