{"id":104,"date":"2023-01-01T11:16:22","date_gmt":"2023-01-01T11:16:22","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=104"},"modified":"2024-07-19T14:18:37","modified_gmt":"2024-07-19T14:18:37","slug":"%d8%aa%d9%82%d9%8a%d9%8a%d9%85-%d9%85%d8%b3%d8%aa%d9%88%d9%8a%d8%a7%d8%aa-%d8%a7%d9%84%d9%86%d9%8a%d9%83%d9%84-%d8%a7%d9%84%d9%85%d8%b5%d9%84%d9%8a%d8%a9-%d8%a7%d9%84%d9%86%d8%a7%d8%ac%d9%85%d8%a9","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=104","title":{"rendered":"\u062a\u0642\u064a\u064a\u0645 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0632\u0631\u0639 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0641\u064a \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0645\u064a"},"content":{"rendered":"<p style=\"text-align: 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srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-4-279x300.png 279w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-4.png 548w\" sizes=\"auto, (max-width: 525px) 100vw, 525px\" \/><figcaption id=\"caption-attachment-436\" class=\"wp-caption-text\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0634\u0643\u0644 .1 \u0628\u0639\u0636 \u0627\u0644\u0635\u0648\u0631 \u0627\u0644\u0634\u0639\u0627\u0639\u064a\u0629 \u0644\u062a\u062b\u0628\u064a\u062a \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0639\u0638\u0645<\/strong><\/span><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0624\u062f\u064a \u0625\u062f\u062e\u0627\u0644 \u0627\u0644\u0632\u0631\u0639\u0627\u062a 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\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u063a\u0644\u0648\u062a\u0627\u062a\u064a\u0648\u0646Glutathione (GSH) \u00a0\u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062e\u0637\u064a\u0631\u0629 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0642\u0644\u064a\u0644 \u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u062c\u0633\u0645 \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u0631\u0637\u0646\u0629 [9]\u060c \u0643\u0645\u0627 \u0628\u064a\u0646\u062a \u062f\u0631\u0627\u0633\u0629 \u0623\u062e\u0631\u0649 \u0648\u062c\u0648\u062f \u0633\u0645\u064a\u0629 \u062e\u0644\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0638\u0645\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0645\u0646 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\u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0633\u0627\u0645\u0629 \u0639\u0646\u062f \u0627\u0631\u062a\u0641\u0627\u0639 \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 [11]\u060c \u0648\u0630\u0644\u0643 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a\u0647 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0643\u0627\u0631\u062a\u0628\u0627\u0637\u0647 \u0628\u0627\u0644\u0623\u0644\u0628\u0648\u0645\u064a\u0646 albumin \u0648\u0623\u0644\u0641\u0627 2 \u0645\u0627\u0643\u0631\u0648\u063a\u0644\u0648\u0628\u0648\u0644\u064a\u0646\u00a0 \u00a0\u03b12-Macroglobulin \u0648\u0644\u0640-\u0647\u064a\u0633\u062a\u064a\u062f\u064a\u0646 L- Histidine \u0648\u062a\u0634\u0643\u064a\u0644\u0647 \u0645\u0639\u0642\u062f\u0627\u062a \u062a\u062a\u0648\u0632\u0639 \u0625\u0644\u0649 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u064a\u062a\u0631\u0627\u0643\u0645 \u0641\u064a \u0627\u0644\u0643\u0628\u062f \u0648\u0627\u0644\u0643\u0644\u0649 \u0648\u0627\u0644\u062f\u0645\u0627\u063a \u0648\u0627\u0644\u0631\u0626\u062a\u064a\u0646 \u0648\u0627\u0644\u0637\u062d\u0627\u0644 \u0648\u0627\u0644\u062e\u0635\u064a\u062a\u064a\u0646 \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0623\u0639\u0636\u0627\u0621 [12] [13] [14]. \u064a\u0642\u0648\u0645 \u0627\u0644\u0646\u064a\u0643\u0644 \u0628\u062a\u0639\u0632\u064a\u0632 \u0639\u0645\u0644\u064a\u0627\u062a \u0641\u0648\u0642 \u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0634\u0651\u064f\u062d\u0648\u0645 Lipid peroxidation\u060c \u0648\u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0648\u0647\u0645\u0627 \u0645\u0646 \u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0641\u064a \u0625\u062d\u062f\u0627\u062b \u0627\u0644\u062a\u0633\u0645\u0645 \u0641\u064a \u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0627\u0648\u0643\u0633\u062c\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a (ROS) Reactive Oxygen Species [11] [14]. \u062a\u0624\u062f\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u062d\u062f\u062b\u0647\u0627 \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0625\u0644\u0649 \u062a\u062e\u0631\u0628 \u0627\u0644\u0640DNA \u0648\u062a\u0639\u062f\u064a\u0644 \u0641\u064a \u062a\u0635\u0646\u064a\u0639 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0648\u0627\u0632\u062f\u064a\u0627\u062f \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u062d\u0641\u0632 \u0628\u0646\u0642\u0635 \u0627\u0644\u062a\u0623\u0643\u0633\u062c\u00a0 Hypoxia-inducible factor 1 (HIF-1) \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u062a\u0637\u0648\u0631 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 [15]. \u0625\u0646 \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0642\u0637\u0639 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u064a\u0643\u0648\u0646 \u0623\u0634\u062f \u0633\u0645\u064a\u0629 \u0648\u062e\u0637\u0648\u0631\u0629 \u0645\u0646 \u0645\u0635\u0627\u062f\u0631 \u062f\u062e\u0648\u0644 \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629 \u0628\u0633\u0628\u0628 \u062a\u062d\u0631\u0631\u0647 \u0645\u0628\u0627\u0634\u0631\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u062d\u064a\u062b \u064a\u0633\u0628\u0628 \u0633\u0645\u064a\u0629 \u0643\u0628\u062f\u064a\u0629 [9]\u060c \u0648\u0627\u0644\u062a\u0647\u0627\u0628 \u0639\u0638\u0645\u064a \u0645\u0641\u0635\u0644\u064a Osteoarthritis \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062a\u0631\u0627\u0643\u0645\u0647 \u0641\u064a \u0627\u0644\u0646\u0633\u062c \u0627\u0644\u0639\u0638\u0645\u064a\u0629 [16]\u060c \u0648\u062d\u062f\u0648\u062b \u0635\u062f\u0627\u0639 \u0645\u062a\u0643\u0631\u0631 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0623\u062d\u064a\u0627\u0646 \u0648\u0623\u0645\u0631\u0627\u0636 \u0641\u064a \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 Cardiovascular diseases \u0648\u062a\u0644\u064a\u0641 \u0628\u0627\u0644\u0631\u0626\u0629 Lung fibrosis \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 [11] [17] [18].<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0647\u062f\u0641 \u0645\u0646 \u0627\u0644\u0628\u062d\u062b:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0647\u062f\u0641 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0625\u0644\u0649 \u0645\u0631\u0627\u0642\u0628\u0629 \u062a\u062d\u0631\u0631 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0632\u0631\u0639 \u0627\u0644\u0642\u0637\u0639 \u0648\u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062c\u0631\u0627\u062d\u064a\u0629 \u0627\u0644\u0639\u0638\u0645\u064a\u0629 \u0644\u0641\u062a\u0631\u0627\u062a \u0632\u0645\u0646\u064a\u0629 \u062f\u0648\u0631\u064a\u0629 \u0645\u062d\u062f\u062f\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0645\u0635\u0644 \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0645\u064a \u0627\u0644\u0630\u064a\u0646 \u062e\u0636\u0639\u0648\u0627 \u0644\u062a\u0644\u0643 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0648\u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0628\u062d\u062b:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0633\u0644\u064a\u0637 \u0627\u0644\u0636\u0648\u0621 \u0639\u0644\u0649 \u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u0639\u0627\u062f\u0646 \u0627\u0644\u0633\u0627\u0645\u0629 \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u062a\u0631\u0643\u064a\u0628 \u0627\u0644\u0642\u0637\u0639 \u0648\u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0648\u0627\u0644\u0628\u0631\u0627\u063a\u064a \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0627\u0644\u0645\u0632\u0631\u0648\u0639\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0645\u064a \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0648\u0630\u0644\u0643 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062a\u0623\u0643\u064a\u062f \u0627\u0644\u0645\u0628\u0627\u0634\u0631 \u0639\u0644\u0649 \u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0641\u064a \u0645\u0635\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062e\u0627\u0636\u0639\u064a\u0646 \u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0632\u0631\u0639 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645 \u062a\u062d\u064a\u064a\u062f \u062f\u0648\u0631 \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0623\u064a \u0634\u062e\u0635 \u0645\u062f\u062e\u0646 \u0648\u0630\u0644\u0643 \u0623\u0646 \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u064a\u0637\u0644\u0642 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0639\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0646\u064a\u0643\u0644 \u062a\u0645\u062a\u0635 \u0639\u0628\u0631 \u0627\u0644\u0637\u0631\u064a\u0642 \u0627\u0644\u062a\u0646\u0641\u0633\u064a [19] [20]\u060c \u0643\u0645\u0627 \u062a\u0645 \u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0644\u0628\u0627\u062a \u00a0\u0641\u064a \u0646\u0638\u0627\u0645\u0647\u0645 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u062d\u064a\u062b \u064a\u062f\u062e\u0644 \u0627\u0644\u0646\u064a\u0643\u0644 \u0628\u0634\u0643\u0644 \u0631\u0626\u064a\u0633\u064a \u0641\u064a \u062a\u0631\u0643\u064a\u0628 \u0647\u0630\u0647 \u0627\u0644\u0645\u0639\u0644\u0628\u0627\u062a \u0648\u0630\u0644\u0643 \u0644\u0636\u0645\u0627\u0646 \u0639\u062f\u0645 \u062f\u062e\u0648\u0644 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u0644\u0644\u0646\u064a\u0643\u0644 \u0639\u0628\u0631 \u0627\u0644\u0637\u0631\u064a\u0642 \u0627\u0644\u0647\u0636\u0645\u064a [21]\u060c \u0648\u0630\u0644\u0643 \u0628\u0647\u062f\u0641 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u062a\u0642\u064a\u064a\u0645 \u062f\u0642\u064a\u0642 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0648\u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u0642\u0637\u0639 \u0648\u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>\u00a0Materials and method <\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>-1<\/strong><strong> \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 <\/strong><strong>\u00a0Study groups<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u062c\u0645\u0648\u0639\u0629 \u0634\u0627\u0647\u062f\u0629 \u0645\u0646 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 \u00a0\u062a\u0643\u0648\u0646\u062a \u0645\u0646 21 \u0634\u062e\u0635\u0627\u064b (12 \u0630\u0643\u0631\u0627\u064b \u0648 9 \u0625\u0646\u0627\u062b) \u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 22 \u0625\u0644\u0649 33 \u0633\u0646\u0629\u060c \u0644\u0645 \u064a\u0639\u0627\u0646\u0650 \u0623\u062d\u062f \u0645\u0646 \u0623\u0641\u0631\u0627\u062f \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0623\u064a \u0623\u0645\u0631\u0627\u0636 \u0638\u0627\u0647\u0631\u0629 \u0623\u0648 \u0623\u064a \u0623\u0630\u064a\u0627\u062a \u0643\u0628\u062f\u064a\u0629 \u0623\u0648 \u0643\u0644\u0648\u064a\u0629. \u0634\u0645\u0644\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 21 \u0634\u062e\u0635\u0627\u064b (16 \u0630\u0643\u0631\u0627\u064b \u0648 5 \u0625\u0646\u0627\u062b) \u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u064631 \u00a0\u0625\u0644\u0649 59 \u0633\u0646\u0629\u060c \u062e\u0636\u0639\u0648\u0627 \u062c\u0645\u064a\u0639\u0647\u0645 \u0644\u0639\u0645\u0644\u064a\u0627\u062a \u062c\u0631\u0627\u062d\u064a\u0629 \u0639\u0638\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u0634\u0627\u0641\u064a \u0627\u0644\u062d\u0643\u0648\u0645\u064a\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u0627\u0628\u0639\u0629 \u0644\u0648\u0632\u0627\u0631\u062a\u064a \u0627\u0644\u062a\u0639\u0644\u064a\u0645 \u0627\u0644\u0639\u0627\u0644\u064a \u0648\u0627\u0644\u0635\u062d\u0629 \u062d\u064a\u062b \u062a\u0645 \u0648\u0636\u0639 \u0642\u0637\u0639 \u0623\u0648 \u0645\u0641\u0627\u0635\u0644 \u0623\u0648 \u0635\u0641\u0627\u0626\u062d \u0645\u0635\u0646\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u0626\u0637 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0644\u0647\u0645 \u0644\u0645\u062f\u0629 \u062a\u0632\u064a\u062f \u0639\u0646 \u0639\u0627\u0645 \u0644\u064a\u062a\u0645 \u0646\u0632\u0639\u0647\u0627 \u0641\u064a\u0645\u0627 \u0628\u0639\u062f \u0645\u0646 \u062c\u0633\u0645 \u0627\u0644\u0645\u0631\u064a\u0636 \u0648\u0641\u0642\u0627\u064b \u0644\u0631\u0623\u064a \u0627\u0644\u0637\u0628\u064a\u0628 \u0627\u0644\u0645\u062e\u062a\u0635.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>-2<\/strong> <strong>\u0627\u0644\u0625\u0639\u062a\u064a\u0627\u0646<\/strong> <strong>\u0648\u062a\u062e\u0632\u064a\u0646<\/strong> <strong>\u0627\u0644\u0639\u064a\u0646\u0627\u062a <\/strong><strong>Sampling and Storage<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0633\u064f\u062d\u0628\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 (21 \u0634\u062e\u0635\u0627\u064b) \u0639\u0644\u0649 \u0641\u062a\u0631\u0627\u062a \u0632\u0645\u0646\u064a\u0629 \u0645\u062a\u0628\u0627\u0639\u062f\u0629 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a \u0639\u0644\u0649 \u0645\u062f\u0627\u0631 \u0639\u0627\u0645 \u0643\u0627\u0645\u0644 \u0628\u0645\u0639\u062f\u0644 \u0645\u0631\u0629 \u0643\u0644 4 \u0623\u0634\u0647\u0631 \u062a\u0642\u0631\u064a\u0628\u0627\u064b\u060c \u0648\u0642\u0633\u0645\u062a \u0639\u064a\u0646\u0627\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 (63 \u0639\u064a\u0646\u0629) \u0625\u0644\u0649 \u062b\u0644\u0627\u062b \u0645\u062c\u0645\u0648\u0639\u0627\u062a (21 \u0639\u064a\u0646\u0629 \u0641\u064a \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629) \u062a\u0628\u0639\u0627\u064b \u0644\u0644\u0645\u062f\u0629 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0627\u0644\u062a\u064a \u0633\u064f\u062d\u0628 \u0627\u0644\u062f\u0645 \u0641\u064a\u0647\u0627\u060c \u0643\u0645\u0627 \u0633\u064f\u062d\u0628\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 (21 \u0639\u064a\u0646\u0629) \u0644\u0645\u0631\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u0642\u0637.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0633\u064f\u062d\u0628 5 \u0645\u064a\u0644\u064a \u0644\u062a\u0631 \u062f\u0645 \u0648\u0631\u064a\u062f\u064a \u0639\u0644\u0649 \u0623\u0646\u0628\u0648\u0628 \u062c\u0627\u0641\u060c \u062b\u0645 \u0646\u064f\u0628\u0630\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u0631\u062f \u0627\u0644\u0645\u0631\u0643\u0632\u064a \u0628\u0633\u0631\u0639\u0629 3000 \u00a0\u062f\u0648\u0631\u0629 \u0641\u064a \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u00a0\u0645\u062f\u0629 10 \u00a0\u062f\u0642\u0627\u0626\u0642 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0645\u0635\u0644 \u060c \u0648\u0648\u0632\u0639\u062a \u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0635\u0644 \u0639\u0644\u0649 \u0623\u0646\u0627\u0628\u064a\u0628 (\u0625\u0628\u064a\u0646\u062f\u0648\u0631\u0641 (\u0648\u062d\u0641\u0638\u062a \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u062f\u0629 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629\u00a0 (- 80 \u00b0C) \u00a0\u0625\u0644\u0649 \u062d\u064a\u0646 \u00a0\u0648\u0642\u062a \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0627\u062a \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0645\u0646 \u0623\u062c\u0644 \u0645\u0639\u0627\u064a\u0631\u0629 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0627\u0644\u0645\u0635\u0644.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>-3<\/strong> <strong>\u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0641\u064a \u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0646\u064a\u0643\u0644<\/strong><strong> Apparatus used for Measurement of Nickel\u00a0 <\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u062a \u0645\u0642\u0627\u064a\u0633\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0635\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0630\u0631\u064a ((\u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0645\u062e\u0628\u0631 \u0627\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0628\u0643\u0644\u064a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0648\u0647\u0648 \u0645\u0646 \u0646\u0648\u0639 \u0641\u0627\u0631\u064a\u0627\u0646 \u00a0Varian SpectrAA-200\u062d\u0627\u0648 \u0639\u0644\u0649 \u0645\u0635\u0628\u0627\u062d \u0627\u0644\u062f\u064a\u062a\u064a\u0631\u064a\u0648\u0645 \u0644\u062a\u0635\u062d\u064a\u062d \u0627\u0644\u062e\u0644\u0641\u064a\u0629 \u0648\u0641\u0631\u0646 \u0627\u0644\u063a\u0631\u0627\u0641\u064a\u062aGTA-100 \u00a0\u0627\u0644\u0645\u0632\u0648\u062f \u0628\u062d\u0627\u0642\u0646 \u0622\u0644\u064a \u0644\u062d\u0642\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0641\u064a \u062d\u062c\u0631\u0629 \u0627\u0644\u0641\u0631\u0646 \u0648\u0630\u0644\u0643 \u0648\u0641\u0642 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u0645\u062d\u062f\u062f \u0628\u0627\u0644\u062c\u062f\u0648\u0644 1 \u0644\u0639\u0646\u0635\u0631 \u0627\u0644\u0646\u064a\u0643\u0644 \u0648\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u00a0 \u0645\u0635\u0628\u0627\u062d \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u0645\u0647\u0628\u0637\u064a \u0627\u0644\u062e\u0627\u0635 \u0628\u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0630\u064a \u064a\u0639\u0645\u0644 \u0628\u0634\u062f\u0629 \u062a\u064a\u0627\u0631 4 \u0645\u064a\u0644\u064a \u0623\u0645\u0628\u064a\u0631 \u0648\u0628\u0637\u0648\u0644 \u0645\u0648\u062c\u0629 232 \u0646\u0627\u0646\u0648\u0645\u062a\u0631 \u0648\u0639\u0631\u0636 \u0627\u0644\u0634\u0642 0.05 \u00a0\u0646\u0627\u0646\u0648\u0645\u062a\u0631)).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-435 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c1-2-e1698494133699-300x193.png\" alt=\"\" width=\"485\" height=\"312\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c1-2-e1698494133699-300x193.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c1-2-e1698494133699-1024x659.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c1-2-e1698494133699-768x494.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c1-2-e1698494133699-1536x988.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c1-2-e1698494133699-2048x1317.png 2048w\" sizes=\"auto, (max-width: 485px) 100vw, 485px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645\u062a \u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u0641\u0642 \u0637\u0631\u064a\u0642\u0629 \u0645\u0632\u064a\u062c \u0627\u0644\u0647\u0636\u0645 \u0627\u0644\u062d\u0627\u0645\u0636\u064a [22]\u060c \u062d\u064a\u062b \u062a\u0643\u0648\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0645\u0646 \u062d\u0645\u0636 \u0627\u0644\u0622\u0632\u0648\u062a \u0627\u0644\u0645\u0631\u0643\u0632 \u0648\u062d\u0645\u0636 \u0641\u0648\u0642 \u0627\u0644\u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0631\u0643\u0632 \u0648\u062d\u0645\u0636 \u0627\u0644\u0643\u0628\u0631\u064a\u062a \u0627\u0644\u0645\u0631\u0643\u0632 \u0648\u0630\u0644\u0643 \u0628\u0627\u0644\u0646\u0633\u0628 (60 % \u060c 20% \u060c20 %) \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>-4<\/strong> <strong>\u0627\u0644\u0643\u0648\u0627\u0634\u0641 \u0648\u0627\u0644\u0645\u062d\u0627\u0644\u064a\u0644 <\/strong><strong>Reagents and solutions<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u062d\u0644\u0648\u0644 \u0639\u064a\u0627\u0631\u064a \u062e\u0632\u064a\u0646 \u0645\u0636\u0628\u0648\u0637 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 1000 \u0645\u0644\u063a\/\u0644\u062a\u0631 (1000 ppm) \u0645\u0646 \u0634\u0631\u0643\u0629 Merck \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064a\u0629\u060c \u062d\u0645\u0636 \u0627\u0644\u0627\u0632\u0648\u062a \u0627\u0644\u0645\u0631\u0643\u0632 65 \u00a0% \u0645\u0646 \u0634\u0631\u0643\u0629 Merck \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064a\u0629 \u060c \u062d\u0645\u0636 \u0627\u0644\u0643\u0628\u0631\u064a\u062a \u0627\u0644\u0643\u062b\u064a\u0641 95-97 % \u0645\u0646 \u0634\u0631\u0643\u0629 Merck \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064a\u0629 \u060c \u062d\u0645\u0636 \u0641\u0648\u0642 \u0627\u0644\u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0631\u0643\u0632 70 % \u0645\u0646 \u0634\u0631\u0643\u0629 Panreac \u0627\u0644\u0625\u0633\u0628\u0627\u0646\u064a\u0629\u060c \u0645\u062d\u0644\u0648\u0644 \u0645\u064a\u062a\u064a\u0644 \u0623\u064a\u0632\u0648\u0628\u0648\u062a\u064a\u0644 \u0643\u064a\u062a\u0648\u0646 (MIBK) \u0645\u0646 \u0634\u0631\u0643\u0629 Prolabo \u0627\u0644\u0641\u0631\u0646\u0633\u064a\u0629\u060c\u00a0 \u0645\u062d\u0644\u0648\u0644 \u0623\u0645\u0648\u0646\u064a\u0648\u0645 \u0628\u064a\u0631\u0648\u0644\u064a\u062f\u064a\u0646 \u062f\u064a \u062a\u064a\u0648 \u0643\u0627\u0631\u0628\u0627\u0645\u0627\u062a (APDC) \u0645\u0646 \u0634\u0631\u0643\u0629 Avonchem \u00a0\u0627\u0644\u0628\u0631\u064a\u0637\u0627\u0646\u064a\u0629\u060c \u0645\u062d\u0644\u0648\u0644 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u062f \u0627\u0644\u0623\u0645\u0648\u0646\u064a\u0648\u0645 \u0645\u0646 \u0634\u0631\u0643\u0629 Panreac \u0627\u0644\u0625\u0633\u0628\u0627\u0646\u064a\u0629\u060c \u0645\u062d\u0644\u0648\u0644 \u0623\u0632\u0631\u0642 \u0627\u0644\u0628\u0631\u0648\u0645\u0648\u062b\u064a\u0645\u0648\u0644\u00a0 \u0645\u0646 \u0634\u0631\u0643\u0629 A. B. Enterprises \u0627\u0644\u0647\u0646\u062f\u064a\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0644\u0644\u0646\u064a\u0643\u0644 \u0648\u0641\u0642 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0627\u0645\u062a\u0635\u0627\u0635\u064a\u0629 \u0644\u0643\u0644 \u0639\u064a\u0627\u0631\u064a \u0628\u062d\u0633\u0628 \u0627\u0644\u062c\u062f\u0648\u0644 2 \u0648\u0627\u0644\u0634\u0643\u06442 .<\/span><\/p>\n<figure id=\"attachment_438\" aria-describedby=\"caption-attachment-438\" style=\"width: 440px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-438\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-3-300x201.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 .2 \u0645\u0646\u062d\u0646\u0649 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0644\u0644\u0646\u064a\u0643\u0644\" width=\"440\" height=\"295\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-3-300x201.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-3.png 406w\" sizes=\"auto, (max-width: 440px) 100vw, 440px\" \/><figcaption id=\"caption-attachment-438\" class=\"wp-caption-text\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 .2 \u0645\u0646\u062d\u0646\u0649 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0644\u0644\u0646\u064a\u0643\u0644<\/span><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 <\/strong><strong>STATISTICAL STUDY<\/strong><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c IBM SPSS Statistics \u0627\u0644\u0625\u0635\u062f\u0627\u0631 26 \u0648\u0628\u0631\u0646\u0627\u0645\u062c2010 \u00a0Microsoft Office Excel \u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0648\u0627\u0644\u0631\u0633\u0648\u0645 \u0627\u0644\u0628\u064a\u0627\u0646\u064a\u0629\u060c \u0648\u0627\u064f\u0639\u062a\u0645\u062f \u0639\u0644\u0649\u00a0 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a (mean) \u00b1 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a (Standard deviation) SD \u0644\u0644\u062a\u0651\u064e\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0642\u064a\u0645.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-439\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c2-1-e1698499727687-300x66.png\" alt=\"\" width=\"671\" height=\"147\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c2-1-e1698499727687-300x66.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c2-1-e1698499727687-1024x225.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c2-1-e1698499727687-768x169.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c2-1-e1698499727687-1536x338.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c2-1-e1698499727687-2048x450.png 2048w\" sizes=\"auto, (max-width: 671px) 100vw, 671px\" \/><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u064f\u0633\u062a\u062e\u062f\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0648\u0644\u0645\u0648\u063a\u0631\u0648\u0641- \u0633\u064a\u0645\u0631\u0646\u0648\u0641 Kolmogorov\u2013\u00a0 Smirnov \u00a0\u0644\u062a\u062d\u062f\u064a\u062f \u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u062a\u0648\u0632\u0639.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0637\u0628\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0631\u0648\u0633\u0643\u0627\u0644 \u0648\u0627\u0644\u064a\u0633 Kruskal-Wallis H \u0648\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0627\u062a \u0627\u0644\u0628\u0639\u062f\u064a\u0629 Post Hoc (Dunn&#8217;s test).<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u064f\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0631\u0633\u0648\u0646 Pearson correlation coefficient \u0644\u062a\u0648\u0636\u064a\u062d \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0628\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0632\u0645\u0646.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u064f\u0639\u062a\u0645\u062f\u062a \u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640<em>P<\/em> <em>P<\/em> \u2264 0.05 \u0643\u0642\u064a\u0645\u0629 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong><strong>RESULTS<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0648\u0644\u0645\u0648\u063a\u0631\u0648\u0641- \u0633\u064a\u0645\u0631\u0646\u0648\u0641Kolmogorov\u2013Smirnov \u00a0\u0643\u0627\u0646\u062a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0645\u0635\u0644 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u0644\u0627 \u062a\u062a\u0628\u0639 \u0627\u0644\u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u062d\u064a\u062b \u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P P &lt; 0.05 \u0644\u0630\u0644\u0643 \u062a\u0645 \u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0631\u0648\u0633\u0643\u0627\u0644-\u0648\u064a\u0644\u064a\u0633Kruskal-Wallis H \u00a0\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0641\u0631\u0648\u0642 \u0628\u064a\u0646 \u0645\u062a\u0648\u0633\u0637\u0627\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P P &lt; 0.0001 \u0645\u062a\u0628\u0648\u0639\u0627\u064b \u0628\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0627\u062a \u0627\u0644\u0628\u0639\u062f\u064a\u0629Post Hoc \u00a0(Dunn&#8217;s test) \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0645\u0639\u0646\u0648\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 3.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-441\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-300x115.png\" alt=\"\" width=\"655\" height=\"251\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-300x115.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-1024x394.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-768x296.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-1536x591.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-2048x788.png 2048w\" sizes=\"auto, (max-width: 655px) 100vw, 655px\" \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P P &lt; 0.0001\u00a0 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u062c\u0648\u0647\u0631\u064a\u0629 \u0648\u062d\u0642\u064a\u0642\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646\u060c \u0648\u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P\u00a0 P &lt; 0.0001\u00a0 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646\u060c \u0648\u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0P = 0.429 \u0623\u064a P &gt; 0.05\u00a0 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0639\u062f\u0645 \u00a0\u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u060c \u0648\u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P\u00a0 P &lt; 0.001\u00a0 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u062c\u0648\u0647\u0631\u064a\u0629 \u0648\u062d\u0642\u064a\u0642\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646\u060c \u0648\u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P\u00a0 P &lt; 0.001\u00a0 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u062c\u0648\u0647\u0631\u064a\u0629 \u0648\u062d\u0642\u064a\u0642\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646\u060c \u0648\u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640P\u00a0 P &lt; 0.0001\u00a0 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u0623\u0647\u0645\u064a\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0627\u0644\u0634\u0643\u0644 3 \u064a\u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0639 \u0627\u0644\u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0645\u0639\u0646\u0648\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629.<\/span><\/p>\n<figure id=\"attachment_440\" aria-describedby=\"caption-attachment-440\" style=\"width: 476px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-440\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-3-300x228.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 3. \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0639 \u0627\u0644\u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0645\u0639\u0646\u0648\u064a\u0629 \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629\" width=\"476\" height=\"362\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-3-300x228.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-3.png 529w\" sizes=\"auto, (max-width: 476px) 100vw, 476px\" \/><figcaption id=\"caption-attachment-440\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 3. \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0639 \u0627\u0644\u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0645\u0639\u0646\u0648\u064a\u0629 \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-441 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-300x115.png\" alt=\"\" width=\"550\" height=\"211\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-300x115.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-1024x394.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-768x296.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-1536x591.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/\u062c3-e1698500008651-2048x788.png 2048w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0642\u064a\u0645 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645 \u0642\u064a\u0627\u0633\u0647\u0627 \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0632\u0645\u0646 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062d\u0633\u0627\u0628 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u00a0 \u0628\u064a\u0631\u0633\u0648\u0646(r) \u00a0\u0641\u0643\u0627\u0646 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0640 P \u0627\u0644\u062e\u0627\u0635 \u0628\u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 P &lt; 0.0001 \u0645\u0645\u0627 \u064a\u0639\u0646\u064a \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0639 \u0627\u0644\u0632\u0645\u0646 \u062d\u064a\u062b (r = &#8211; 0.928) \u0623\u064a \u0623\u0646\u0647 \u062a\u0648\u062c\u062f \u0639\u0644\u0627\u0642\u0629 \u0639\u0643\u0633\u064a\u0629 \u0642\u0648\u064a\u0629 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0632\u0645\u0646 \u062d\u064a\u062b \u062a\u062a\u0646\u0627\u0642\u0635 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u0639 \u0645\u0631\u0648\u0631 \u0627\u0644\u0632\u0645\u0646 \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u0634\u0643\u0644 4.<\/span><\/p>\n<figure id=\"attachment_442\" aria-describedby=\"caption-attachment-442\" style=\"width: 434px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-442\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/4-1-300x191.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 .4 \u0627\u0644\u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u064a \u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0639 \u0627\u0644\u0632\u0645\u0646\" width=\"434\" height=\"276\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/4-1-300x191.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/4-1.png 421w\" sizes=\"auto, (max-width: 434px) 100vw, 434px\" \/><figcaption id=\"caption-attachment-442\" class=\"wp-caption-text\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 .4 \u0627\u0644\u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u064a \u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0639 \u0627\u0644\u0632\u0645\u0646<\/span><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Discussion <\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0644\u0646\u064a\u0643\u0644 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u062e\u0644\u0627\u0644 \u0627\u0644\u0623\u0634\u0647\u0631 \u0627\u0644\u0623\u0631\u0628\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u062a\u0627\u0631\u064a\u062e \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062c\u0631\u0627\u062d\u064a\u0629 \u0627\u0644\u0639\u0638\u0645\u064a\u0629 \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0645\u064a \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u062d\u064a\u062b \u0625\u0646 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629\u00a0 P &lt; 0.0001 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u062a\u0633\u0631\u0628 \u0639\u0627\u0644\u064d \u0644\u0634\u0648\u0627\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0646 \u0627\u0644\u062f\u0639\u0627\u0626\u0645 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0645\u0646 \u062e\u0644\u064a\u0637 \u0627\u0644\u0645\u0639\u0627\u062f\u0646 \u0648\u0639\u0628\u0648\u0631\u0647\u0627 \u0625\u0644\u0649 \u0627\u0644\u0633\u0648\u0627\u0626\u0644 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0648\u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 [7] [6]\u060c \u0643\u0645\u0627 \u0644\u0648\u062d\u0638 \u0628\u0623\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0645\u0635\u0644 \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0645\u064a \u0641\u064a \u0627\u0644\u062b\u0644\u062b \u0627\u0644\u0632\u0645\u0646\u064a \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 (4 \u0623\u0634\u0647\u0631) \u0643\u0627\u0646 \u0645\u0631\u062a\u0641\u0639\u0627\u064b \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u0628\u0641\u0627\u0631\u0642 \u0630\u064a \u0623\u0647\u0645\u064a\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 P &lt; 0.0001 \u0648\u0644\u0643\u0646\u0647 \u0623\u0642\u0644 \u0645\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0641\u064a \u0627\u0644\u062b\u0644\u062b \u0627\u0644\u0632\u0645\u0646\u064a \u0627\u0644\u0623\u0648\u0644 \u0648\u0628\u0641\u0627\u0631\u0642 \u0625\u062d\u0635\u0627\u0626\u064a \u0647\u0627\u0645 \u0623\u064a\u0636\u0627\u064b P &lt; 0.0001 \u060c \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0623\u0646 \u062a\u062d\u0631\u0631 \u0634\u0648\u0627\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0646 \u0627\u0644\u062f\u0639\u0627\u0626\u0645 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0639\u0638\u0645 \u0645\u0627 \u0632\u0627\u0644 \u0645\u0633\u062a\u0645\u0631\u0627\u064b \u062e\u0644\u0627\u0644 \u0641\u062a\u0631\u0629 \u0627\u0644\u0623\u0631\u0628\u0639\u0629 \u0634\u0647\u0648\u0631 \u0627\u0644\u062b\u0627\u0646\u064a\u0629\u060c \u0648\u0643\u0627\u0646\u062a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0645\u064a \u0641\u064a \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0632\u0645\u0646\u064a \u0627\u0644\u062b\u0627\u0644\u062b \u0645\u062a\u0642\u0627\u0631\u0628\u0629 \u0645\u0639 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0644\u0646\u064a\u0643\u0644 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u062d\u064a\u062b \u0623\u0646 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629\u00a0 P &gt; 0.05\u00a0 \u0623\u064a \u0623\u0646\u0647 \u0644\u0627 \u064a\u0648\u062c\u062f \u0641\u0627\u0631\u0642 \u062c\u0648\u0647\u0631\u064a \u0648\u062d\u0642\u064a\u0642\u064a \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0627\u0644\u0633\u0627\u0628\u0642\u062a\u064a\u0646 \u0648\u0647\u0630\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0627\u0646\u062a\u0647\u0627\u0621 \u062a\u062d\u0631\u0631 \u0627\u0644\u0646\u064a\u0643\u0644 \u0645\u0646 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0627\u0644\u0645\u0632\u0631\u0648\u0639\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0623\u0631\u0628\u0639\u0629 \u0623\u0634\u0647\u0631 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0648\u0627\u0644\u0623\u062e\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0643\u0645\u0627 \u062a\u0628\u064a\u0646 \u0644\u0646\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u064a\u0636\u0627\u064b \u0628\u0623\u0646 \u062a\u062d\u0631\u0631 \u0634\u0648\u0627\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644 \u062a\u0646\u0627\u0642\u0635 \u062a\u062f\u0631\u064a\u062c\u064a\u0627\u064b \u0645\u0639 \u0645\u0631\u0648\u0631 \u0627\u0644\u0632\u0645\u0646 \u0648\u0647\u0630\u0627 \u0645\u0627 \u062a\u0628\u0644\u0648\u0631 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0639\u0643\u0633\u064a\u0629 \u0642\u0648\u064a\u0629 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0646\u064a\u0643\u0644 \u0648\u0645\u0624\u0634\u0631 \u0627\u0644\u0632\u0645\u0646 \u062d\u064a\u062b r = &#8211; 0.928 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0623\u0646 \u0630\u0631\u0648\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u0646\u064a\u0643\u0644 \u0643\u0627\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 (\u0627\u0644\u0623\u0634\u0647\u0631 \u0627\u0644\u0623\u0631\u0628\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649) \u0645\u0646 \u0625\u062c\u0631\u0627\u0621 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0632\u0631\u0639 \u0648\u0627\u0633\u062a\u0645\u0631 \u0647\u0630\u0627 \u0627\u0644\u062a\u062d\u0631\u0631 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u0645\u062f\u0629 \u0632\u0627\u062f\u062a \u0639\u0646 8 \u0623\u0634\u0647\u0631 (\u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629) \u0648\u0644\u0643\u0646 \u0628\u0646\u0633\u0628\u0629 \u0623\u0642\u0644 \u0648\u062a\u0646\u0627\u0642\u0635 \u062a\u062d\u0631\u0631 \u0627\u0644\u0646\u064a\u0643\u0644 \u062a\u062f\u0631\u064a\u062c\u064a\u0627\u064b \u0628\u0639\u062f \u0647\u0630\u0647 \u0627\u0644\u0641\u062a\u0631\u0629 \u0625\u0644\u0649 \u0623\u0646 \u0648\u0635\u0644 \u0625\u0644\u0649 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0637\u0628\u064a\u0639\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a \u0648\u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a <\/strong><strong>Conclusions and Recommendations<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0633\u062a\u0646\u062a\u062c \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u062c\u0648\u062f \u062a\u0633\u0631\u0628 \u0639\u0627\u0644\u064d \u0645\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u062e\u0636\u0639\u0648\u0627 \u0644\u0639\u0645\u0644\u064a\u0627\u062a \u062c\u0631\u0627\u062d\u064a\u0629 \u0639\u0638\u0645\u064a\u0629 \u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u062a\u062d\u0631\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0642\u0637\u0639 \u0648\u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0627\u0644\u0645\u0632\u0631\u0648\u0639\u0629 \u0641\u064a \u0623\u062c\u0633\u0627\u0645\u0647\u0645\u060c \u062d\u064a\u062b \u064a\u0645\u062a\u062f \u0647\u0630\u0627 \u0627\u0644\u062a\u0633\u0631\u0628 \u0644\u0641\u062a\u0631\u0627\u062a \u0632\u0645\u0646\u064a\u0629 \u0637\u0648\u064a\u0644\u0629 (8 \u0623\u0634\u0647\u0631) \u0648\u0627\u0644\u0630\u064a \u064a\u0646\u0639\u0643\u0633 \u0633\u0644\u0628\u0627\u064b \u0639\u0644\u0649 \u0635\u062d\u0629 \u0627\u0644\u0645\u0631\u0636\u0649, \u062d\u064a\u062b \u0625\u0646 \u062a\u062d\u0631\u0631 \u0627\u0644\u0634\u0648\u0627\u0631\u062f \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 \u064a\u062c\u0628 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0645\u0639\u062f\u0648\u0645\u0627\u064b \u0644\u0636\u0645\u0627\u0646 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0623\u064a \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0644\u0647\u0627.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062e\u0631\u062c\u062a \u0647\u0630\u0647 \u0631\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0639\u062f\u0629 \u062a\u0648\u0635\u064a\u0627\u062a \u0645\u0646\u0647\u0627:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u062a\u0646\u0628\u0647 \u0625\u0644\u0649 \u062e\u0637\u0631 \u0627\u0644\u0646\u064a\u0643\u0644 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0648\u0627\u0644\u0628\u0631\u0627\u063a\u064a \u0648\u0627\u0644\u0645\u0633\u0627\u0645\u064a\u0631 \u0627\u0644\u0645\u0635\u0646\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u0626\u0637 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u062f\u0627\u062e\u0644 \u0623\u062c\u0633\u0627\u0645 \u0645\u0631\u0636\u0649 \u0627\u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0645\u064a.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0636\u0631\u0648\u0631\u0629 \u0625\u062c\u0631\u0627\u0621 \u0645\u0642\u0627\u064a\u0633\u0627\u062a \u062f\u0648\u0631\u064a\u0629 \u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u064a\u0643\u0644 \u0648\u0627\u0644\u0645\u0639\u0627\u062f\u0646 \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u062a\u0631\u0643\u064a\u0628 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0627\u0644\u0645\u0632\u0631\u0648\u0639\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062c\u0631\u0627\u062d\u064a\u0629 \u0627\u0644\u0639\u0638\u0645\u064a\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0627\u062c \u0648\u0642\u062a\u0627\u064b \u0637\u0648\u064a\u0644\u0627\u064b \u0644\u0646\u0632\u0639\u0647\u0627 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0636\u0631\u0648\u0631\u0629 \u0625\u062c\u0631\u0627\u0621 \u0641\u062d\u0648\u0635 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0633\u0648\u0627\u0626\u0644 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0627\u0635\u0637\u0646\u0627\u0639\u064a\u0629 \u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u0646\u064a\u0643\u0644 \u0648\u0627\u0644\u0645\u0639\u0627\u062f\u0646 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\u0627\u0644\u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0636\u0631\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0644\u062c\u0623 \u0625\u0644\u064a\u0647\u0627 \u0623\u0637\u0628\u0627\u0621 \u0627\u0644\u062c\u0631\u0627\u062d\u0629 \u0627\u0644\u0639\u0638\u0645\u064a\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0639\u0638\u0645 \u0644\u0648\u0636\u0639\u0647 \u0627\u0644\u0637\u0628\u064a\u0639\u064a&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=104\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":436,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-134","volume-9"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=104"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/104\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/436"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}