{"id":113,"date":"2023-01-01T11:29:18","date_gmt":"2023-01-01T11:29:18","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=113"},"modified":"2024-07-19T14:11:16","modified_gmt":"2024-07-19T14:11:16","slug":"%d8%b5%d9%8a%d8%a7%d8%ba%d8%a9-%d9%85%d8%b6%d8%ba%d9%88%d8%b7%d8%a7%d8%aa-%d9%82%d8%a7%d8%a8%d9%84%d8%a9-%d9%84%d9%84%d8%aa%d9%81%d8%aa%d9%91%d8%aa-%d9%81%d9%8a-%d8%a7%d9%84%d9%81%d9%85-%d9%84%d9%85","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=113","title":{"rendered":"\u0635\u064a\u0627\u063a\u0629 \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u0651\u062a \u0641\u064a \u0627\u0644\u0641\u0645 \u0644\u0645\u0627\u062f\u0651\u0629 \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0628\u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0645\u0639 \u0645\u0627\u062f\u0651\u0629 \u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a 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\u0635\u064a\u0627\u063a\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0636\u0645\u0646 \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645 \u0641\u0644\u0645 \u062a\u0630\u0643\u0631 \u0627\u0644\u0623\u062f\u0628\u064a\u0627\u062a \u0648\u0644\u0627 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0635\u064a\u0627\u063a\u0629 \u0647\u0630\u0647 \u0627\u0644\u0645\u0627\u062f\u0629 \u0636\u0645\u0646 \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645. \u0623\u064f\u062c\u0631\u064a \u0627\u0644\u0628\u062d\u062b \u0641\u064a \u0645\u062d\u0631\u0643 \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a &#8220;\u063a\u0648\u063a\u0644 \u0633\u0643\u0648\u0644\u0627\u0631 Google scholar&#8221; \u0627\u0633\u062a\u0646\u0627\u062f\u064b\u0627 \u0625\u0644\u0649 \u0627\u0644\u0643\u0644\u0645\u0627\u062a \u0627\u0644\u0645\u0641\u062a\u0627\u062d\u064a\u0629 \u0627\u0644\u0622\u062a\u064a\u0629 \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0627\u0646\u0643\u0644\u064a\u0632\u064a: \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a\u060c \u0645\u0634\u0627\u0631\u0643\u0629 \u0628\u064a\u0646 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0648\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\u060c \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a&#8221;\u060c \u0644\u0645 \u062a\u0638\u0647\u0631 \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0628\u062d\u062b \u0623\u064a\u0629 \u0646\u062a\u0627\u0626\u062c \u0623\u0648 \u0623\u0648\u0631\u0627\u0642 \u0628\u062d\u062b\u064a\u0629 \u0645\u0634\u062a\u0631\u0643\u0629 \u0645\u0627 \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0627\u0644\u0645\u0630\u0643\u0648\u0631\u062a\u064a\u0646 \u0636\u0645\u0646 \u0623\u064a \u0634\u0643\u0644 \u0635\u064a\u062f\u0644\u0627\u0646\u064a \u062c\u0631\u0639\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0625\u0644\u0649 \u062f\u0631\u0627\u0633\u0629 \u0645\u062f\u0649 \u0627\u0644\u062a\u0648\u0627\u0641\u0642\u064a\u0629 \u0628\u064a\u0646 \u0645\u0627\u062f\u0629 \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0644\u062f\u0649 \u0648\u062c\u0648\u062f\u0647\u0645\u0627 \u0636\u0645\u0646 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a \u0646\u0641\u0633\u0647 Orally Disintegrating Tablets (ODTs) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0641\u062d\u0648\u0635 IR \u0648DSC\u060c \u0648\u0645\u0646 \u062b\u0645 \u0635\u064a\u0627\u063a\u0629 \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645 \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0648\u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong> <strong>Materials and methods<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 (Apex Healthcare, India)\u060c \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a (Saneca Pharmaceuticals Hlohovec, Slovakia)\u060c \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u062c\u064a\u0644 (JRS Pharma, India)\u060c \u0627\u0644\u0643\u0631\u0648\u0633 \u0643\u0627\u0631\u0645\u064a\u0644\u0648\u0632 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 (Shandong Head Co, China)\u060c \u0634\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0632\u064a\u0648\u0645 (Nitika Pharmaceuticals Specialities, India)\u060c \u0627\u0644\u0645\u0627\u0646\u064a\u062a\u0648\u0644 (Signet Chemical Corporation, India)\u060c \u0627\u0644\u0623\u0641\u064a\u0633\u064a\u0644 PH-102 (Antika pulps and boards, India).<\/span><\/p>\n<h2 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0623\u062c\u0647\u0632\u0629 \u0627\u0644\u0645\u0633\u062a\u0639\u0645\u0644\u0629 <\/strong><strong>Devices and Instruments<\/strong><\/span><\/h2>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0627\u0644\u0623\u062c\u0647\u0632\u0629 \u0627\u0644\u0622\u062a\u064a\u0629: \u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633 (Satorius GP 2102, Germany)\u060c \u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633 \u062a\u062d\u0644\u064a\u0644\u064a (Precisa XB 220A, Switzerland) \u0628\u062f\u0642\u0629 0.0010 \u063a\u0631\u0627\u0645\u060c \u0633\u062e\u0627\u0646 \u0643\u0647\u0631\u0628\u0627\u0626\u064a \u0645\u0639 \u062e\u0644\u0627\u0637 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a\u060c \u062d\u0627\u0636\u0646\u0629 \u062b\u0628\u0627\u062a (Humidity Chamber HCP50, Memmert, Germany)\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 (HPLC, Shimadzu Prominence PDA SPD-20A<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif;\">Japan)\u060c \u062d\u0645\u0627\u0645 \u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0635\u0648\u062a\u064a\u0629 (PHYLO USH-10D, Italy)\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0627\u0644\u0645\u0631\u0626\u064a \u0648\u0627\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 (HITACHI UV-VIS Spectrophotometer, U-1800, Japan)\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a (Mettler Toledo, Switzerland)\u060c \u062c\u0647\u0627\u0632 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 (Erweka, Type DT800, Germany)\u060c \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u0627\u0644\u0628\u0627\u0647\u0627\u0621 (HANNA instruments PH Microscopic pH Meter, USA)\u060c \u062c\u0647\u0627\u0632 \u0627\u062e\u062a\u0628\u0627\u0631 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a (Erweka ZT320, Germany)\u060c \u0622\u0644\u0629 \u0636\u063a\u0637 \u0645\u062e\u0628\u0631\u064a\u0629 (Erweka EK-0, Motor Drive AR 402, Germany)\u060c \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u0627\u0644\u0642\u0633\u0627\u0648\u0629 \u0648\u0627\u0644\u0633\u0645\u0627\u0643\u0629 (Erweka TBH300 S, Germany)\u060c \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u0627\u0644\u0647\u0634\u0627\u0634\u0629 (Erweka TAR20, Germany)\u060c \u0645\u0631\u0627\u0634\u062d \u0646\u0627\u064a\u0644\u0648\u0646 \u0644\u0644\u0645\u062d\u0627\u0642\u0646 (Whatman, Germany)\u060c \u0645\u0646\u0627\u062e\u0644 \u062f\u0633\u062a\u0648\u0631\u064a\u0629 (CISA, UK).<\/span><\/p>\n<h3 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0645\u062a\u0648\u0627\u0642\u062a\u0629 \u0644\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 HPLC:<\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0645 \u062a\u0631\u062f \u0641\u064a \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629 \u0623\u0648 \u0627\u0644\u0623\u062f\u0628\u064a\u0627\u062a \u0623\u064a\u0629 \u0637\u0631\u0627\u0626\u0642 \u0644\u0644\u062a\u0639\u064a\u064a\u0646 \u0627\u0644\u0645\u062a\u0648\u0627\u0642\u062a \u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 HPLC. \u0644\u0630\u0644\u0643 \u0637\u064f\u0648\u0651\u0631\u062a \u0637\u0631\u064a\u0642\u0629 \u062a\u062d\u0644\u064a\u0644\u064a\u0629 \u0644\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 HPLC \u0628\u0639\u062f \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0635\u0641\u0627\u062a \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629\u060c \u062d\u064f\u062f\u0651\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0643\u0634\u0641 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a\u0629:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0648\u0639 \u0627\u0644\u0639\u0645\u0648\u062f: C<sub>18<\/sub> (mm150\u00d7mm4.6) \u062d\u062c\u0645 \u0627\u0644\u062d\u0628\u064a\u0628\u0627\u062a 5\u00b5.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0642\u064a\u0627\u0633: 214 nm.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0639\u062f\u0644 \u0627\u0644\u062a\u062f\u0641\u0642: 1.1 ml\/min.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0645\u062a\u062d\u0631\u0643: \u0645\u064a\u062a\u0627\u0646\u0648\u0644\/\u0648\u0642\u0627\u0621 \u0641\u0633\u0641\u0627\u062a\u064a pH=2.3 (4:6).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0630\u064a\u0628 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0639\u064a\u0627\u0631\u064a: \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0627\u0644\u0645\u062d\u0645\u0636 \u0628\u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0631\u0643\u0632 methanolic hydrochrloic acid \u0628\u062a\u0631\u0643\u064a\u0632 0.01 N.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u0634\u0627\u0647\u062f: 0.1 \u0645\u0644\u063a\/\u0645\u0644 \u0644\u0643\u0644\u0627 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646.<\/span><\/p>\n<h3 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a\u0629 :Standard Solutions<\/span><\/h3>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062d\u0636\u064a\u0631 \u0645\u062d\u0644\u0648\u0644 \u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0644\u0648\u062d\u062f\u0647\u0627 \u0628\u062a\u0631\u0643\u064a\u0632 0.1 \u0645\u0644\u063a\/\u0645\u0644:<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u064f\u0648\u0632\u0646 10 \u0645\u0644\u063a \u0645\u0646 \u0645\u0627\u062f\u0629 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u062a\u0646\u0642\u0644 \u0644\u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u0629 100 \u0645\u0644\u060c \u0648\u062a\u0630\u0627\u0628 \u0628\u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0627\u0644\u0645\u062d\u0645\u0636 \u0628\u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 0.01N \u062b\u0645 \u064a\u0645\u062f\u062f \u0627\u0644\u062d\u062c\u0645 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0627\u0644\u0645\u062d\u0645\u0636 \u0628\u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621\u060c \u062a\u0648\u0636\u0639 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0645\u062f\u0629 15 \u062f\u0642\u064a\u0642\u0629.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062d\u0636\u064a\u0631 \u0645\u062d\u0644\u0648\u0644 \u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0644\u0648\u062d\u062f\u0647\u0627 \u0628\u062a\u0631\u0643\u064a\u0632 0.1 \u0645\u0644\u063a\/\u0645\u0644:<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u064f\u0648\u0632\u0646 10 \u0645\u0644\u063a \u0645\u0646 \u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0648\u062a\u0646\u0642\u0644 \u0644\u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u0629 100 \u0645\u0644\u060c \u0648\u062a\u0630\u0627\u0628 \u0628\u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0627\u0644\u0645\u062d\u0645\u0636 \u0628\u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 0.01N \u062b\u0645 \u064a\u0645\u062f\u062f \u0627\u0644\u062d\u062c\u0645 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0627\u0644\u0645\u062d\u0645\u0636 \u0628\u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621\u060c \u062a\u0648\u0636\u0639 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0645\u062f\u0629 15 \u062f\u0642\u064a\u0642\u0629.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0628\u062a\u0631\u0643\u064a\u0632 50 \u0645\u0643\u063a\/\u0645\u0644 \u0644\u0643\u0644\u0627 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646:<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0648\u0636\u0639 \u0641\u064a \u062f\u0648\u0631\u0642 \u0645\u0639\u064a\u0627\u0631\u064a \u0633\u0639\u0629 50 \u0645\u0644 25 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0627\u0644\u0623\u0645\u060c 25 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0627\u0644\u0623\u0645\u060c \u062b\u0645 \u062a\u0648\u0636\u0639 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0645\u062f\u0629 15 \u062f\u0642\u064a\u0642\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645 <\/strong><strong>ODTs<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0645 \u062a\u0634\u0631 \u0627\u0644\u0623\u062f\u0628\u064a\u0627\u062a \u0625\u0644\u0649 \u0623\u064a\u0629 \u0645\u0634\u0627\u0631\u0643\u0629 \u062f\u0648\u0627\u0626\u064a\u0629 \u0628\u064a\u0646 \u0645\u0627\u062f\u0629 \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0636\u0645\u0646 \u0646\u0641\u0633 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u060c \u0644\u0630\u0644\u0643 \u0643\u0627\u0646 \u0644\u0627 \u0628\u062f \u0645\u0646 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0644\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0633\u0644\u0627\u0645\u0629 \u0647\u0630\u0647 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0648\u0639\u062f\u0645 \u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062b\u0628\u0627\u062a\u064a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0645\u0633\u062a\u062d\u0636\u0631 \u0627\u0644\u0645\u062d\u0636\u0631.<\/span><a name=\"_Toc92090976\"><\/a><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u00a0\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0635\u064a\u0627\u063a\u0629 <\/strong><strong>Preformulation Study<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0623\u062c\u0644 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u0645\u062a\u0633\u0627\u0648\u064a \u062d\u0631\u0627\u0631\u064a\u0627\u064b<\/strong><strong> Isothermal Stress Testing (IST) <\/strong><sup>(6)<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u064f\u0632\u062c \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0645\u0639 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0628\u0646\u0633\u0628\u0629 1:1 \u0645\u0632\u062c\u064b\u0627 \u0647\u0646\u062f\u0633\u064a\u064b\u0627 \u0644\u062a\u062d\u0642\u064a\u0642 \u0627\u0644\u062a\u062c\u0627\u0646\u0633. \u0648\u062d\u064f\u0641\u0638\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0636\u0645\u0646 \u062d\u0627\u0636\u0646\u0629 \u062b\u0628\u0627\u062a \u0645\u0636\u0628\u0648\u0637\u0629 \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0648\u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0627\u0644\u0646\u0633\u0628\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0646\u062d\u0648 \u0627\u0644\u0622\u062a\u064a: \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 40 \u0645 \u0648\u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0627\u0644\u0646\u0633\u0628\u064a\u0629 75%\u060c \u0648\u0630\u0644\u0643 \u0644\u0645\u062f\u0629 6 \u0623\u0634\u0647\u0631 \u0648\u0641\u0642 \u062a\u0648\u0635\u064a\u0627\u062a \u0627\u0644\u0640\u0640\u0640ICH \u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u0631\u0639. \u062d\u064f\u0644\u0651\u0644\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0639\u064a\u0627\u0646\u064a\u0627\u064b \u0648\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0627\u062a DSC \u0648FTIR \u0648HPLC \u0648\u0630\u0644\u0643 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0628\u064a\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0648\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u062a\u0622\u062b\u0631 \u0627\u0644\u0645\u062d\u062a\u0645\u0644.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0635\u064a\u0627\u063a\u0629 <\/strong><strong>formulation Study<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0633\u0651\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0641\u062a\u062a\u0629 \u0644\u062a\u062d\u0642\u064a\u0642 \u062a\u0641\u062a\u062a \u0645\u0646\u0627\u0633\u0628 \u0644\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0639 \u0632\u0645\u0646 \u062a\u0641\u062a\u062a \u0633\u0631\u064a\u0639. \u062d\u064f\u0636\u0651\u0631\u062a \u062a\u0633\u0639 \u0635\u064a\u063a \u062f\u0648\u0627\u0626\u064a\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0628\u0627\u0634\u0631 \u0645\u0648\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (1)\u060c \u0648\u0637\u064f\u0628\u0642\u0651\u062a \u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u062e\u0627\u0635\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0639\u062f\u0651 \u0644\u0644\u0636\u063a\u0637 \u0642\u0628\u0644 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0636\u063a\u0637\u060c \u0648\u0639\u0644\u0649 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0628\u0639\u062f \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0636\u063a\u0637.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u0639\u0645\u0644:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064f\u0636\u0651\u0631\u062a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u0633\u0639 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0628\u0627\u0634\u0631 (DC) Direct Compression\u060c \u0627\u0633\u062a\u062e\u062f\u0645 \u0633\u0648\u0627\u063a \u0623\u0641\u064a\u0633\u064a\u0644 PH102 \u0641\u064a \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0635\u064a\u063a \u0628\u0648\u0635\u0641\u0647\u0627 \u0645\u0627\u062f\u0629 \u0645\u0627\u0644\u0626\u0629 \u0644\u0623\u0646\u0647\u0627 \u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0628\u0627\u0634\u0631\u060c \u0643\u0645\u0627 \u0623\u0646\u0647\u0627 \u062a\u0645\u062a\u0644\u0643 \u062e\u0648\u0627\u0635 \u0645\u062d\u0633\u0646\u0629 \u0644\u0644\u0627\u0646\u0633\u064a\u0627\u0628\u064a\u0629\u060c \u0648\u0623\u0636\u064a\u0641 \u0633\u0648\u0627\u063a \u0627\u0644\u0645\u0627\u0646\u064a\u062a\u0648\u0644 \u0628\u0648\u0635\u0641\u0647 \u0639\u0627\u0645\u0644\u064b\u0627 \u0645\u0645\u062f\u062f\u064b\u0627 \u0644\u0644\u0635\u064a\u063a\u0629 \u0648\u0644\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u062e\u0648\u0627\u0635\u0647 \u0627\u0644\u0645\u062d\u0644\u064a\u0629 \u0644\u0623\u0646\u0647 \u064a\u0639\u0637\u064a \u0625\u062d\u0633\u0627\u0633 \u0628\u0627\u0644\u0628\u0631\u0648\u062f\u0629 \u0648\u0645\u0627\u0635\u0651\u0627\u064b \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0644\u062f\u0649 \u062a\u0645\u0627\u0633\u0647 \u0645\u0639 \u0627\u0644\u0644\u0639\u0627\u0628 \u0641\u064a \u0627\u0644\u0641\u0645\u060c \u0627\u0633\u062a\u064f\u062e\u062f\u0645\u062a \u0634\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0632\u064a\u0648\u0645 \u0628\u062a\u0631\u0643\u064a\u0632 1% \u0628\u0648\u0635\u0641\u0647\u0627 \u0645\u0627\u062f\u0629 \u0645\u0627\u0646\u0639\u0629 \u0644\u0644\u0627\u0644\u062a\u0635\u0627\u0642 \u0636\u0645\u0646 \u062d\u062c\u0631 \u0627\u0644\u0636\u063a\u0637. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u064f\u0632\u062c\u062a \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0645\u0632\u062c\u064b\u0627 \u0647\u0646\u062f\u0633\u064a\u064b\u0627 \u062c\u064a\u062f\u0627\u064b \u062d\u062a\u0649 \u062a\u0645\u0627\u0645 \u0627\u0644\u0645\u0632\u062c\u060c \u0648\u0623\u062e\u064a\u0631\u0627\u064b \u0623\u0636\u064a\u0641\u062a \u0634\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0632\u064a\u0648\u0645 \u0648\u0645\u064f\u0632\u062c\u062a \u0627\u0644\u0635\u064a\u063a \u0644\u0645\u062f\u0629 5 \u062f\u0642\u0627\u0626\u0642. \u0631\u064f\u0639\u064a \u0627\u0644\u062a\u0633\u0644\u0633\u0644 \u0641\u064a \u062a\u062d\u0636\u064a\u0631 \u0643\u0627\u0641\u0629 \u0627\u0644\u0635\u064a\u063a. \u0648\u0636\u064f\u063a\u0637 \u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0633\u0627\u062d\u064a\u0642 \u0636\u0645\u0646 \u0645\u0643\u0628\u0633 \u0631\u0642\u0645 8.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-412\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-300x228.png\" alt=\"\" width=\"682\" height=\"519\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-300x228.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-1024x778.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-768x583.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-1536x1167.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-2048x1555.png 2048w\" sizes=\"auto, (max-width: 682px) 100vw, 682px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645 \u0628\u0639\u062f \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0636\u063a\u0637 <\/strong><strong>Evaluation of ODTs<\/strong><strong>:<\/strong><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0627\u0644\u0642\u0633\u0627\u0648\u0629 Hardness test:<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0627\u0644\u0647\u0634\u0627\u0634\u0629 Friability test:<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0627\u0644\u0642\u0637\u0631 \u0648\u0627\u0644\u0633\u0645\u0627\u0643\u0629 Diameter and thickness test:<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0648\u0632\u0646 Weight Variation Test:<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 Content uniformity test:<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0648\u064a\u0631\u062a \u0627\u0644\u0645\u0627\u062f\u062a\u0627\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u0627\u0646 \u0641\u064a \u0645\u062e\u062a\u0644\u0641 \u0635\u064a\u063a \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629. \u0625\u0630 \u0623\u064f\u062e\u0630\u062a 10 \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0648\u0633\u062d\u0642\u062a\u060c \u0648\u0623\u064f\u062e\u0630 \u0645\u0627 \u064a\u0639\u0627\u062f\u0644 10 \u0645\u0644\u063a \u0645\u0646 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u064810 \u0645\u0644\u063a \u0645\u0646 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0625\u0644\u0649 \u0628\u064a\u0634\u0631 \u0630\u0627\u062a \u062d\u062c\u0645 100 \u0645\u0644\u060c \u0648\u062d\u064f\u0644\u0651\u062a \u0641\u064a 10 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0627\u0644\u0645\u062d\u0645\u0636 \u0628\u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 0.01N \u0645\u0639 \u0627\u0644\u062a\u062d\u0631\u064a\u0643\u060c \u0648\u0645\u064f\u062f\u062f \u062d\u062a\u0649 \u062a\u0645\u0627\u0645 \u0627\u0644\u062d\u062c\u0645 \u0628\u0627\u0644\u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a\u064a pH 6.8 \u0641\u064a\u0643\u0648\u0646 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 0.1 \u0645\u0644\u063a\/\u0645\u0644 \u0648\u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a 0.1 \u0645\u0644\u063a\/\u0645\u0644. \u064a\u0631\u0634\u062d \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0628\u0645\u0631\u0627\u0634\u062d \u0645\u064a\u0643\u0631\u0648\u0646\u064a\u0629 0.45 \u0645\u0643\u0645\u060c \u0623\u064f\u062c\u0631\u064a \u0627\u0644\u0642\u064a\u0627\u0633 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 HPLC. \u064a\u064f\u062c\u0631\u0649 \u0643\u0644 \u0642\u064a\u0627\u0633 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a<sup>(7)<\/sup>.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 Dissolution test:<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0630\u0627\u062a \u0627\u0644\u0645\u062c\u062f\u0627\u0641 USP \u01c1 paddle \u0628\u0633\u0631\u0639\u0629 \u062a\u062d\u0631\u064a\u0643 50 \u062f\u0648\u0631\u0629\/\u062f\u0642\u064a\u0642\u0629 \u0636\u0645\u0646 \u0648\u0633\u0637 \u0630\u0648\u0628\u0627\u0646 900 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0633\u0641\u0627\u062a\u064a pH 6.8\u060c \u0625\u0630 \u0636\u064f\u0628\u0637\u062a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0639\u0646\u062f 37\u00b10.5 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629. \u0648\u0637\u064f\u0628\u0651\u0642 \u0627\u0644\u0641\u062d\u0635 \u0639\u0644\u0649 \u0633\u062a \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0641\u064a \u062d\u062c\u0645 900 \u0645\u0644 \u0644\u0643\u0644 \u0645\u0636\u063a\u0648\u0637\u0629\u060c \u062b\u0645 \u0633\u064f\u062d\u0628\u062a \u0639\u064a\u0646\u0627\u062a 5 \u0645\u0644 \u0639\u0646\u062f \u0627\u0644\u0623\u0632\u0645\u0646\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0628\u0627\u0644\u062f\u0642\u0627\u0626\u0642 (1\u060c 2\u060c 3\u060c 5\u060c 10). \u0631\u064f\u0634\u062d\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u062d\u0648\u0628\u0629 \u0628\u0645\u0631\u0627\u0634\u062d \u063a\u0634\u0627\u0626\u064a\u0629 0.45 \u0645\u0643\u0645\u060c \u0648\u0639\u064f\u0648\u0651\u0636\u062a \u0628\u0643\u0645\u064a\u0627\u062a \u0645\u062a\u0633\u0627\u0648\u064a\u0629 \u0645\u0646 \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u060c \u0628\u0639\u062f \u0630\u0644\u0643 \u0642\u064a\u0633\u062a \u0627\u0644\u0645\u0633\u0627\u062d\u0629 \u062a\u062d\u062a \u0627\u0644\u0645\u0646\u062d\u0646\u064a AUC \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 HPLC. <sup>(8)<\/sup><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a Disintegration test:<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0628\u0648\u0636\u0639 \u0633\u062a \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0645\u0623\u062e\u0648\u0630\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0627\u064b \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0636\u0645\u0646 \u062c\u0647\u0627\u0632 \u0627\u062e\u062a\u0628\u0627\u0631 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a\u060c \u0625\u0630 \u0648\u064f\u0636\u0639 900 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 37 \u00b1 2 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629\u060c \u0648\u0627\u062d\u062a\u064f\u0633\u0628 \u0627\u0644\u0632\u0645\u0646 \u0627\u0644\u0644\u0627\u0632\u0645 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u062a\u0641\u062a\u062a \u0627\u0644\u0643\u0627\u0645\u0644 \u0644\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a\u060c \u062d\u062a\u0649 \u0636\u0645\u0627\u0646 \u0639\u062f\u0645 \u0628\u0642\u0627\u0621 \u0623\u064a \u0628\u0642\u0627\u064a\u0627 \u0636\u0645\u0646 \u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0644\u0629 \u0648\u0639\u062f\u0651\u0647 \u0632\u0645\u0646 \u062a\u0641\u062a\u062a<sup>(9)<\/sup>. \u064a\u064f\u062c\u0631\u0649 \u0643\u0644 \u0642\u064a\u0627\u0633 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u062d\u0635 \u0632\u0645\u0646 \u0627\u0644\u062a\u0628\u0644\u0644 Wetting Time test:<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0628\u0648\u0636\u0639 \u0633\u062a \u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0636\u0645\u0646 \u0637\u0628\u0642 \u0628\u064a\u062a\u0631\u064a \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 6 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 \u0648\u0648\u0631\u0642\u0629 \u062a\u0631\u0634\u064a\u062d \u0642\u0637\u0646\u064a\u0629\u060c \u0627\u062d\u062a\u064f\u0633\u0628 \u0627\u0644\u0632\u0645\u0646 \u0627\u0644\u0644\u0627\u0632\u0645 \u0645\u0646 \u0623\u062c\u0644 \u0623\u0646 \u062a\u062a\u0628\u0644\u0644 \u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0623\u0648 \u0627\u0644\u0632\u0645\u0646 \u0627\u0644\u0644\u0627\u0632\u0645 \u0644\u0643\u064a \u064a\u0635\u0644 \u0627\u0644\u0645\u0627\u0621 \u0644\u0623\u0639\u0644\u0649 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a <sup>(9)<\/sup>. \u064a\u062c\u0631\u0649 \u0643\u0644 \u0642\u064a\u0627\u0633 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a. <\/span><a name=\"_Toc92090980\"><\/a><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Results and Discussion<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0645\u062a\u0648\u0627\u0642\u062a\u0629 \u0644\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 HPLC:<\/span><a name=\"_Toc103885297\"><\/a><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 Assy:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0637\u064f\u0628\u0642\u062a \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a\u0629 \u0627\u0644\u0645\u0637\u0648\u0631\u0629 \u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0645\u0624\u0634\u0631\u0627\u062a \u0645\u0644\u0627\u0626\u0645\u0629 \u0627\u0644\u0646\u0638\u0627\u0645 System suitability \u0648\u0630\u0644\u0643 \u0628\u062d\u0642\u0646 \u0633\u062a \u062d\u0642\u0646 \u0645\u062a\u062a\u0627\u0644\u064a\u0629 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0645\u064a\u0632 Resolution solution \u0648\u062d\u0633\u0627\u0628 \u0639\u0627\u0645\u0644 \u0627\u0644\u062a\u0630\u064a\u064a\u0644 Tailing factor\u060c \u0639\u062f\u062f \u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u0646\u0638\u0631\u064a\u0629 Theorical plates\u060c \u0627\u0644\u0645\u064a\u0632 Resolution\u060c \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0646\u0633\u0628\u064a RSD \u0644\u0645\u0633\u0627\u062d\u0629 \u0642\u0645\u0645 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (2) \u0648\u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0639\u0644\u0649 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0622\u062a\u064a:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0627\u0645\u0644 \u0627\u0644\u062a\u0630\u064a\u064a\u0644: \u0623\u0642\u0644 \u0645\u0646 1.5.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u062f\u062f \u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u0646\u0638\u0631\u064a\u0629: \u0623\u0643\u062b\u0631 \u0645\u0646 2000.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u064a\u0632: \u0623\u0643\u0628\u0631 \u0645\u0646 1.5.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0646\u0633\u0628\u064a: \u0623\u0642\u0644 \u0645\u0646%2.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0637\u0628\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0644\u0627\u0626\u0645\u0629 \u0627\u0644\u0646\u0638\u0627\u0645 \u0641\u064a \u0628\u062f\u0627\u064a\u0629 \u0643\u0644 \u0639\u0645\u0644\u064a\u0629 \u062a\u062d\u0644\u064a\u0644\u064a\u0629.<\/span><\/p>\n<table style=\"width: 71.1184%;\">\n<tbody>\n<tr>\n<td style=\"width: 112.315%;\" colspan=\"5\" width=\"566\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (2): \u0645\u0639\u0627\u064a\u064a\u0631 \u0645\u0644\u0627\u0621\u0645\u0629 \u0627\u0644\u0646\u0638\u0627\u0645 <\/strong><strong>System Suitability Test <\/strong><strong>\u00a0\u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 16.5049%;\" width=\"78\"><strong>\u0627\u0644\u0645\u0627\u062f\u0629<\/strong><\/td>\n<td style=\"width: 21.0356%;\" width=\"126\"><strong>\u0632\u0645\u0646 \u0627\u0644\u0627\u062d\u062a\u0628\u0627\u0633 (\u062f) <\/strong><strong>Retention Time<\/strong><\/td>\n<td style=\"width: 14.8867%;\" width=\"88\"><strong>\u0639\u0627\u0645\u0644 \u0627\u0644\u062a\u0630\u064a\u064a\u0644 <\/strong><strong>Tailing Factor<\/strong><\/td>\n<td style=\"width: 17.4757%;\" width=\"104\"><strong>\u0627\u0644\u0645\u064a\u0632 <\/strong><strong>Resolution<\/strong><\/td>\n<td style=\"width: 42.4121%;\" width=\"171\"><strong>\u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u0646\u0638\u0631\u064a\u0629 <\/strong><strong>Theoretical usp plates<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 16.5049%;\" width=\"78\"><strong>\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645<\/strong><\/td>\n<td style=\"width: 21.0356%;\" width=\"126\">3.955<\/td>\n<td style=\"width: 14.8867%;\" width=\"88\">1.220<\/td>\n<td style=\"width: 17.4757%;\" width=\"104\">8.649<\/td>\n<td style=\"width: 42.4121%;\" width=\"171\">2881974.65<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 16.5049%;\" width=\"78\"><strong>\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a<\/strong><\/td>\n<td style=\"width: 21.0356%;\" width=\"126\">1.462<\/td>\n<td style=\"width: 14.8867%;\" width=\"88\">1.417<\/td>\n<td style=\"width: 17.4757%;\" width=\"104\">&#8211;<\/td>\n<td style=\"width: 42.4121%;\" width=\"171\">2857275<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 (1\u060c 2\u060c 3) \u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u062d\u0642\u0646 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\u060c \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0648\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628\u060c \u0625\u0630 \u062a\u0638\u0647\u0631 \u0627\u0644\u0642\u0645\u0645 \u0639\u0646\u062f \u0632\u0645\u0646 \u0627\u062d\u062a\u0628\u0627\u0633 (3.955 \u062f\u0642\u064a\u0642\u0629) \u0648(1.462 \u062f\u0642\u064a\u0642\u0629) \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628\u060c \u0648\u0647\u0630\u0627 \u064a\u0624\u0643\u062f \u062f\u0642\u0629 \u0627\u0644\u0641\u0635\u0644 \u0628\u064a\u0646 \u0642\u0645\u0645 \u0627\u0644\u0645\u0648\u0627\u062f \u0645\u0646 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u062a\u062f\u0627\u062e\u0644. \u062d\u064f\u0633\u0628\u062a \u0627\u0644\u0645\u0633\u0627\u062d\u0629 \u062a\u062d\u062a \u0627\u0644\u0642\u0645\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u0622\u0644\u064a \u0627\u0644\u0645\u0648\u0635\u0648\u0644 \u0645\u0639 \u062c\u0647\u0627\u0632 HPLC.<\/span><\/p>\n<figure id=\"attachment_392\" aria-describedby=\"caption-attachment-392\" style=\"width: 526px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-392 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-e1699711410870-300x167.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 1: \u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u062d\u0642\u0646 \u0645\u062d\u0644\u0648\u0644 \u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\" width=\"526\" height=\"293\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-e1699711410870-300x167.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-e1699711410870.jpg 753w\" sizes=\"auto, (max-width: 526px) 100vw, 526px\" \/><figcaption id=\"caption-attachment-392\" class=\"wp-caption-text\"><strong>\u0627\u0644\u0634\u0643\u0644 1: \u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u062d\u0642\u0646 \u0645\u062d\u0644\u0648\u0644 \u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645<\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_393\" aria-describedby=\"caption-attachment-393\" style=\"width: 540px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-393 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-e1699711332254-300x163.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 2: \u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u062d\u0642\u0646 \u0645\u062d\u0644\u0648\u0644 \u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a\" width=\"540\" height=\"293\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-e1699711332254-300x163.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-e1699711332254-768x418.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/2-e1699711332254.jpg 787w\" sizes=\"auto, (max-width: 540px) 100vw, 540px\" \/><figcaption id=\"caption-attachment-393\" class=\"wp-caption-text\"><strong>\u0627\u0644\u0634\u0643\u0644 2: \u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u062d\u0642\u0646 \u0645\u062d\u0644\u0648\u0644 \u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a<\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_394\" aria-describedby=\"caption-attachment-394\" style=\"width: 555px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-394\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-300x133.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 3: \u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u062d\u0642\u0646 \u0645\u062d\u0644\u0648\u0644 \u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a\" width=\"555\" height=\"246\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-300x133.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-768x340.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3.jpg 855w\" sizes=\"auto, (max-width: 555px) 100vw, 555px\" \/><figcaption id=\"caption-attachment-394\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 3: \u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u062d\u0642\u0646 \u0645\u062d\u0644\u0648\u0644 \u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a:<\/strong><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0639\u064a\u0627\u0646\u064a:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0638\u0647\u0631\u062a \u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0642\u0628\u0644 \u0627\u0644\u062d\u0641\u0638 \u0648\u0628\u0639\u062f\u0647 \u0645\u0633\u062d\u0648\u0642\u064b\u0627 \u0623\u0628\u064a\u0636 \u0634\u0627\u062d\u0628\u064b\u0627 \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0648\u0645\u0633\u062d\u0648\u0642\u064b\u0627 \u0623\u0635\u0641\u0631 \u0628\u0627\u0647\u062a\u064b\u0627 \u0645\u062a\u0643\u062a\u0644 \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0642\u0628\u0644 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062d\u0641\u0638 \u0648\u0628\u0639\u062f\u0647 \u0641\u064a \u0634\u0631\u0648\u0637 \u0627\u0644\u062d\u0641\u0638 \u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u0631\u0639 (\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 40 \u0645 \u0648\u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0627\u0644\u0646\u0633\u0628\u064a\u0629 75%). \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u062b\u0646\u0627\u0626\u064a\u0629 \u0628\u0646\u0633\u0628\u0629 (1:1) \u0641\u062a\u0638\u0647\u0631 \u0645\u062d\u0627\u0641\u0638\u0629 \u0645\u0632\u064a\u062c \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645-\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0639\u0644\u0649 \u062e\u0648\u0627\u0635\u0647 \u0627\u0644\u0639\u064a\u0627\u0646\u064a\u0629 \u0637\u064a\u0644\u0629 \u0645\u062f\u0629 \u0627\u0644\u062d\u0641\u0638 \u0641\u064a \u0627\u0644\u0634\u0631\u0648\u0637 (RH75%\/40\u00b0C).<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u062a\u0627\u0626\u062c <\/strong><strong>\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0641\u0631\u062f\u064a\u0629 \u0648\u0627\u0644\u0645\u0632\u0627\u0626\u062c \u0644\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0628\u0648\u0627\u0633\u0637\u0629<\/strong> <strong>:HPLC<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u064f\u0648\u062d\u0638 \u0627\u0646\u062e\u0641\u0627\u0636 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0641\u064a \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0632\u0645\u0646 \u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062d\u0641\u0638 (RH 75%\/40<sup>\u00b0<\/sup>C) \u0645\u0639 \u0628\u0642\u0627\u0621 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0641\u0648\u0642 90% \u0644\u0643\u0644\u0627 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646\u060c \u0648\u0643\u0627\u0646 \u0627\u0644\u0623\u0642\u0644 \u062a\u0623\u062b\u0651\u0631\u0627\u064b \u0647\u0648 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0627\u0644\u0646\u0642\u064a \u064a\u0644\u064a\u0647 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0627\u0644\u0646\u0642\u064a.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a <\/strong><strong>Differential scanning calorimetry<\/strong><strong>: <\/strong><strong><sup>(10)<\/sup><\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u062c\u0631\u0649 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 DSC \u0646\u0648\u0639 (Mettler Toledo, Switzerland) \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0643\u0644\u0651\u064d \u0639\u0644\u0649 \u062d\u062f\u0629\u060c \u0648\u0645\u0632\u064a\u062c\u0647\u0645\u0627 \u0628\u0646\u0633\u0628\u064d \u0645\u062a\u0633\u0627\u0648\u064a\u0629 (1:1). \u0648\u064f\u0632\u0646\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u062c\u0627\u0641\u0629 \u062a\u0645\u0627\u0645\u064b\u0627 \u0648\u0632\u0646\u064b\u0627 \u062f\u0642\u064a\u0642\u064b\u0627 \u062d\u0648\u0627\u0644\u064a (5-7) \u0645\u0644\u063a\u060c \u0645\u0639 \u0648\u0636\u0639\u0647\u0627 \u0636\u0645\u0646 \u0628\u0648\u062a\u0642\u0629 \u062e\u0627\u0635\u0629 \u0645\u0635\u0646\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645\u060c \u0648\u0623\u064f\u062d\u0643\u0645 \u0625\u063a\u0644\u0627\u0642\u0647\u0627 \u062c\u064a\u062f\u064b\u0627 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0643\u0628\u0633 \u062e\u0627\u0635\u060c \u062b\u0645 \u0623\u064f\u062c\u0631\u064a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0648\u062a\u0642\u0629 \u0623\u062e\u0631\u0649 \u0641\u0627\u0631\u063a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645 \u0634\u0627\u0647\u062f\u064b\u0627 \u0648\u0630\u0644\u0643 \u0628\u062a\u0639\u0631\u064a\u0636 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0625\u0644\u0649 \u062d\u0631\u0627\u0631\u0629 \u0645\u062a\u0632\u0627\u064a\u062f\u0629 \u0636\u0645\u0646 \u0627\u0644\u0645\u062c\u0627\u0644 25-400 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629 \u0628\u0645\u0639\u062f\u0644 (10 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629\/\u062f\u0642\u064a\u0642\u0629) \u0648\u062a\u062d\u062a \u062a\u062f\u0641\u0642 \u063a\u0627\u0632 \u0627\u0644\u0622\u0632\u0648\u062a N<sub>2<\/sub>. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0638\u0647\u0650\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u062e\u0637\u064b\u0627 \u0628\u064a\u0627\u0646\u064a\u064b\u0627 \u064a\u062a\u0636\u0645\u0646 \u0642\u0645\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 endothermic \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 202.58 <sup>0<\/sup>\u0645 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u064a \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0646\u0634\u0631\u062a \u0639\u0627\u0645 2020\u0645. <sup>(11) <\/sup><\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0638\u0647\u0631\u062a \u0642\u0645\u0629 \u0623\u062e\u0631\u0649 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 exothermic \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 253.36 <sup>0<\/sup>\u0645 \u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0639\u0627\u0626\u062f\u0629 \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0625\u0644\u0649 \u0639\u0645\u0644\u064a\u0629 \u062a\u062e\u0631\u0628 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0628\u0639\u062f \u0627\u0646\u0635\u0647\u0627\u0631\u0647. (\u0627\u0644\u0634\u0643\u0644 4). <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0623\u0638\u0647\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a (\u0627\u0644\u0634\u0643\u0644 5) \u062e\u0637\u064b\u0627 \u0628\u064a\u0627\u0646\u064a\u064b\u0627 \u064a\u062a\u0636\u0645\u0646 \u0642\u0645\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 endothermic \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 61.51 <sup>0<\/sup>\u0645 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u0628\u062e\u0631 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0636\u0645\u0646 \u0628\u0646\u064a\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0644\u0623\u0646 \u0627\u0644\u0645\u0644\u062d \u0647\u064a\u0645\u064a \u0647\u062f\u0631\u0627\u062a. \u0648\u0623\u0628\u062f\u0649 \u0627\u0644\u0645\u062e\u0637\u0637 \u0642\u0645\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 endothermic \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 246.34 <sup>0<\/sup>\u0645 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u064a \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0647\u064a\u0645\u064a \u0647\u064a\u062f\u0631\u0627\u062a.<\/span><\/p>\n<figure id=\"attachment_395\" aria-describedby=\"caption-attachment-395\" style=\"width: 471px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-395\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/4-300x200.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 4: \u0645\u062e\u0637\u0637 DSC \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\" width=\"471\" height=\"314\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/4-300x200.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/4-768x512.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/4.jpg 1020w\" sizes=\"auto, (max-width: 471px) 100vw, 471px\" \/><figcaption id=\"caption-attachment-395\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 4: \u0645\u062e\u0637\u0637 DSC \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_396\" aria-describedby=\"caption-attachment-396\" style=\"width: 473px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-396\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-1-300x200.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 5: \u0645\u062e\u0637\u0637 DSC \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a\" width=\"473\" height=\"315\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-1-300x200.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-1-768x511.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-1.jpg 1020w\" sizes=\"auto, (max-width: 473px) 100vw, 473px\" \/><figcaption id=\"caption-attachment-396\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 5: \u0645\u062e\u0637\u0637 DSC \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_397\" aria-describedby=\"caption-attachment-397\" style=\"width: 477px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-397\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/6-1-300x201.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 6: \u0645\u062e\u0637\u0637 DSC \u0644\u0645\u0632\u064a\u062c \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\/ \u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a (1\/1)\" width=\"477\" height=\"320\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/6-1-300x201.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/6-1-768x515.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/6-1.jpg 1024w\" sizes=\"auto, (max-width: 477px) 100vw, 477px\" \/><figcaption id=\"caption-attachment-397\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 6: \u0645\u062e\u0637\u0637 DSC \u0644\u0645\u0632\u064a\u062c \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\/ \u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a (1\/1)<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0627\u0644\u0639\u0648\u062f\u0629 \u0625\u0644\u0649 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0644\u0645\u0632\u064a\u062c \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a (1\/1) (\u0627\u0644\u0634\u0643\u0644 6) \u064a\u0638\u0647\u0631 \u0644\u062f\u064a\u0646\u0627 \u0642\u0645\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 endothermic \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 80.05 <sup>0<\/sup>\u0645 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u0628\u062e\u0631 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0636\u0645\u0646 \u0628\u0646\u064a\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0644\u0623\u0646 \u0627\u0644\u0645\u0644\u062d \u0647\u064a\u0645\u064a \u0647\u062f\u0631\u0627\u062a\u060c \u0648\u0623\u0638\u0647\u0631 \u0627\u0644\u0645\u062e\u0637\u0637 \u0642\u0645\u0629 \u062d\u0627\u062f\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 endothermic \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 198.69 <sup>0<\/sup>\u0645 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0646\u0632\u064a\u0627\u062d \u0648\u0627\u0636\u062d \u0641\u064a \u0642\u0645\u0629 \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0628\u0645\u0642\u062f\u0627\u0631 3.89 <sup>0<\/sup>\u0645 \u0645\u0639 \u062a\u063a\u064a\u0631 \u0648\u0627\u0636\u062d \u062c\u062f\u064b\u0627 \u0641\u064a \u0627\u0646\u062a\u0627\u0644\u0628\u064a\u0629 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u0645\u0642\u062f\u0627\u0631 37.72 J\/g\u060c \u0648\u0623\u0638\u0647\u0631 \u0623\u064a\u0636\u064b\u0627 \u0642\u0645\u0629 \u0634\u0628\u0647 \u062d\u0627\u062f\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 253.15 <sup>0<\/sup>\u0645 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0646\u0632\u064a\u0627\u062d \u0641\u064a \u0642\u0645\u0629 \u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0628\u0645\u0642\u062f\u0627\u0631 6.81 <sup>0<\/sup>\u0645\u00a0 \u0645\u0639 \u062a\u063a\u064a\u0631 \u0648\u0627\u0636\u062d \u0641\u064a \u0627\u0646\u062a\u0627\u0644\u0628\u064a\u0629 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u0645\u0642\u062f\u0627\u0631 108.34 J\/g. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0646 \u062b\u0645\u0651 \u064a\u062a\u0636\u062d \u0628\u0645\u062e\u0637\u0637\u0627\u062a DSC \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u0645\u062a\u0633\u0627\u0648\u064a \u062d\u0631\u0627\u0631\u064a\u064b\u0627 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0623\u0646\u0647 \u0647\u0646\u0627\u0644\u0643 \u062a\u062f\u0627\u062e\u0644\u064b\u0627 \u0641\u064a\u0632\u064a\u0627\u0626\u064a\u064b\u0627 \u0635\u0644\u0628\u064b\u0627-\u0635\u0644\u0628\u064b\u0627 \u0628\u064a\u0646 \u0645\u0627\u062f\u0629 \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0645\u0627\u062f\u0629 \u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a\u060c \u064a\u0624\u062b\u0631 \u0641\u064a \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0643\u0644\u0627 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0645\u0646 \u062f\u0648\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0641\u064a \u062a\u0631\u0643\u064a\u0632\u0647\u0645\u0627 \u0627\u0644\u062f\u0648\u0627\u0626\u064a.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 <\/strong><strong>FTIR Spectroscopy: <\/strong><strong><sup>(6)<\/sup><\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0648\u0636\u062d \u0627\u0644\u0634\u0643\u0644 (7) \u0623\u0647\u0645 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0636\u0645\u0646 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\u060c \u0648\u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0648\u0647\u0630\u0627 \u0645\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0646\u0634\u0631\u0647\u0627 \u062c\u0627\u0628\u0631 \u0639\u0627\u0645 2013.<sup> (12) <\/sup><\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u064a\u0648\u0636\u062d \u0627\u0644\u0634\u0643\u0644 (8) \u0623\u0647\u0645 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0636\u0645\u0646 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a\u060c \u0648\u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621\u060c \u0625\u0630 \u0623\u0638\u0647\u0631 \u0627\u0644\u0637\u064a\u0641 \u0639\u0635\u0627\u0628\u0629 \u0627\u0647\u062a\u0632\u0627\u0632 \u062a\u0645\u062a\u062f 1900-3000 \u0633\u0645<sup>-1<\/sup> \u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0639\u0627\u0626\u062f\u0629 \u0625\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646 \u0627\u0644\u062b\u0627\u0644\u062b\u064a\u060c \u0639\u0644\u0649 \u062d\u064a\u0646 \u0627\u0644\u0639\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u0645\u0648\u0636\u0639 3460 \u0633\u0645<sup>-1<\/sup> \u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0639\u0627\u0626\u062f\u0629 \u0625\u0644\u0649\u00a0 \u0645\u062c\u0645\u0648\u0639\u0629OH \u00a0\u00a0\u0636\u0645\u0646 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0645\u0634\u0643\u0644\u0629 \u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u062f\u0627\u062e\u0644 \u062c\u0632\u064a\u0626\u064a\u0629 \u0636\u0645\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u060c \u0627\u0644\u0639\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0646\u062f \u0623\u0637\u0648\u0627\u0644 \u0627\u0644\u0645\u0648\u062c\u0629 525\u060c 1126\u060c 1263 \u0633\u0645<sup>-1<\/sup>\u0639\u0627\u0626\u062f\u0629 \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0625\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0627\u062a <strong>\u1db9<\/strong><sub>P=O<\/sub>, <strong>\u1db9<\/strong><sub>P-O<\/sub>, <strong><em>\u03b3<\/em><\/strong><sub>P=O<\/sub>\u060c \u0648\u0639\u0635\u0627\u0628\u0629 \u0627\u0644\u0627\u0647\u062a\u0632\u0627\u0632 \u0639\u0646\u062f \u0627\u0644\u0645\u0648\u0636\u0639 925 \u0633\u0645-<sup>1<\/sup> \u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0639\u0627\u0626\u062f\u0629 \u0644 \u0645\u062c\u0645\u0648\u0639\u0629C=H \u00a0\u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0646\u0634\u0631\u062a \u0639\u0627\u0645 2006. <sup>(13)<\/sup><\/span><\/p>\n<figure id=\"attachment_398\" aria-describedby=\"caption-attachment-398\" style=\"width: 514px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-398 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/7-e1698424394856-300x116.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 7: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (FTIR) \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\" width=\"514\" height=\"199\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/7-e1698424394856-300x116.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/7-e1698424394856-768x298.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/7-e1698424394856.jpg 956w\" sizes=\"auto, (max-width: 514px) 100vw, 514px\" \/><figcaption id=\"caption-attachment-398\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 7: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (FTIR) \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_399\" aria-describedby=\"caption-attachment-399\" style=\"width: 530px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-399 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/8-e1698425219782-300x112.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 8: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (FTIR) \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a\" width=\"530\" height=\"198\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/8-e1698425219782-300x112.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/8-e1698425219782-768x286.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/8-e1698425219782.jpg 960w\" sizes=\"auto, (max-width: 530px) 100vw, 530px\" \/><figcaption id=\"caption-attachment-399\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 8: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (FTIR) \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_400\" aria-describedby=\"caption-attachment-400\" style=\"width: 563px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-400 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/9-e1698425729473-300x111.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 9: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (FTIR) \u0644\u0645\u0632\u064a\u062c \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\/ \u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a (1\/1)\" width=\"563\" height=\"208\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/9-e1698425729473-300x111.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/9-e1698425729473-768x285.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/9-e1698425729473.jpg 963w\" sizes=\"auto, (max-width: 563px) 100vw, 563px\" \/><figcaption id=\"caption-attachment-400\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 9: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (FTIR) \u0644\u0645\u0632\u064a\u062c \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645\/ \u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a (1\/1)<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0648\u0636\u062d \u0627\u0644\u0634\u0643\u0644 (9) \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0645\u0632\u064a\u062c \u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0628\u0646\u0633\u0628\u0629 (1\/1)\u060c \u0625\u0630 \u0623\u0628\u062f\u0649 \u0637\u064a\u0641 \u0627\u0644\u0640 (FTIR) \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0627\u0644\u0622\u062a\u064a\u0629 (v, cm<sup>-1<\/sup>): 524\u060c 775\u060c 939\u060c 1118\u060c 1149\u060c 1300\u060c 1350\u060c 1435\u060c 1527\u060c 1629\u060c 3336. \u064a\u0644\u0627\u062d\u0638 \u0628\u0642\u0627\u0621 \u0639\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0628\u0627\u0631\u0632\u0629 \u0648\u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0645\u0639 \u062d\u0635\u0648\u0644 \u0627\u0646\u0632\u064a\u0627\u062d (shift) \u0637\u0641\u064a\u0641 \u0641\u064a \u0645\u0648\u0627\u0642\u0639\u0647\u0627\u060c \u0646\u0644\u062d\u0638 \u0627\u062e\u062a\u0641\u0627\u0621 \u0627\u0644\u0639\u0635\u0627\u0628\u0629 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0641\u064a \u0637\u064a\u0641 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0636\u0645\u0646 \u0637\u064a\u0641 \u0627\u0644\u0645\u0632\u064a\u062c \u0639\u0646\u062f \u0627\u0644\u0639\u0635\u0627\u0628\u0629 \u0627\u0644\u062a\u064a \u062a\u0645\u062a\u062f 1900-3000\u00a0 \u0633\u0645<sup>-1<\/sup> \u0648\u0627\u062e\u062a\u0641\u0627\u0621 \u0639\u0635\u0627\u0628\u0629 \u0627\u0644\u0627\u0647\u062a\u0632\u0627\u0632 \u0639\u0646\u062f 3460 \u0633\u0645<sup>-1<\/sup> \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644\u060c \u0645\u0639 \u062d\u0635\u0648\u0644 \u0627\u0646\u0632\u064a\u0627\u062d \u0648\u0627\u0636\u062d \u0628\u0639\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0628\u0627\u0631\u0632\u0629 \u0648\u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0636\u0645\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u060c \u0647\u0630\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u062a\u062f\u0627\u062e\u0644 \u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u064a\u0646 \u0645\u0646 \u062b\u0645\u0651 \u062a\u062f\u0639\u0645 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0640 FTIR \u0648\u062c\u0648\u062f \u062a\u062f\u0627\u062e\u0644 \u0628\u064a\u0646 \u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0644\u062f\u0649 \u0645\u0632\u062c\u0647\u0645\u0627 \u0645\u0639\u064b\u0627\u060c \u0647\u0630\u0627 \u064a\u062a\u0641\u0642 \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0627\u0644\u062d\u0631\u0627\u0631\u064a DSC. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0633\u062a\u0628\u0639\u062f \u0648\u062c\u0648\u062f \u062a\u062f\u0627\u062e\u0644 \u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0628\u0646\u062a\u064a\u062c\u0629 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u0645\u062a\u0633\u0627\u0648\u064a \u062d\u0631\u0627\u0631\u064a\u064b\u0627 \u0648\u0623\u0646 \u0627\u0644\u062a\u062e\u0631\u0628 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0627\u0644\u062d\u0627\u0635\u0644 \u0644\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0641\u064a \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0637\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (3) \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0637\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0639\u062f \u0644\u0644\u0636\u0651\u063a\u0637 \u0645\u0639 \u0642\u064a\u0645 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a SD. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0644\u062d\u0638 \u0645\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (3) \u0623\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u062a\u062a\u0645\u062a\u0639 \u0628\u0627\u0646\u0633\u064a\u0627\u0628\u064a\u0629 \u062c\u064a\u062f\u0629 \u0625\u0644\u0649 \u0645\u0645\u062a\u0627\u0632\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><a name=\"_Toc92090996\"><\/a><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0628\u0639\u062f \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0636\u063a\u0637 <\/strong><strong>Evaluation of ODTs<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (4) \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0637\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645 \u0628\u0639\u062f \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0636\u063a\u0637 \u0645\u0639 \u0642\u064a\u0645 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a SD.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211; \u0636\u064f\u0628\u0637\u062a \u0622\u0644\u0629 \u0627\u0644\u0636\u063a\u0637 \u0628\u062d\u064a\u062b \u062a\u062a\u0631\u0627\u0648\u062d \u0642\u0633\u0627\u0648\u0629 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0628\u064a\u0646 (2.5-5 \u0643\u063a\/\u0633\u0645<sup>2<\/sup>). \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u0642\u064a\u0645 \u0642\u0633\u0627\u0648\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0645\u0627 \u0628\u064a\u0646 (2.6-5.13 \u0643\u063a\/\u0633\u0645<sup>2<\/sup>)\u060c \u0648\u0643\u0627\u0646\u062a \u0642\u064a\u0645 \u0627\u0644\u0647\u0634\u0627\u0634\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u0645\u0642\u0628\u0648\u0644\u0629 \u062f\u0633\u062a\u0648\u0631\u064a\u0627\u064b (&gt; 1%).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211; \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0641\u062d\u0635 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0648\u0632\u0646 \u0643\u0627\u0646\u062a \u0627\u0644\u0642\u064a\u0645 \u062a\u062a\u0631\u0627\u0648\u062d \u0645\u0627 \u0628\u064a\u0646 (187.15-205.10 \u0645\u0644\u063a) \u0648\u0647\u064a \u0636\u0645\u0646 \u0634\u0631\u0648\u0637 \u0627\u0644\u0642\u0628\u0648\u0644 \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211; \u062a\u0631\u0627\u0648\u062d \u0642\u0637\u0631 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0636\u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0641\u062d\u0648\u0635\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u0628\u064a\u0646 (8.87-8.93) \u0645\u0639 \u0627\u0644\u0639\u0644\u0645 \u0623\u0646 \u0642\u0637\u0631 \u0645\u0643\u064a\u0633 \u0622\u0644\u0629 \u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 (8 \u0645\u0644\u0645)\u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0639\u0632\u0649 \u0627\u0644\u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0642\u0637\u0631 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0628\u0639\u062f \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0636\u063a\u0637 \u0625\u0644\u0649 \u0627\u0644\u062a\u0634\u0648\u0647 \u0627\u0644\u0645\u0631\u0646 \u0627\u0644\u062d\u0627\u0635\u0644 \u0644\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0648\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (5) \u0642\u064a\u0645 \u0632\u0645\u0646\u064a \u0627\u0644\u062a\u0641\u062a\u062a \u0648\u0627\u0644\u062a\u0628\u0644\u0644 \u0648\u0646\u0633\u0628\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u0627\u0621 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u0633\u0639 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0625\u0630 \u0623\u0628\u062f\u062a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u0633\u0639 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062a\u0641\u0627\u0648\u062a\u064b\u0627 \u0628\u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0645\u0627 \u0628\u064a\u0646 (6-110) \u062b\u0627\u0646\u064a\u0629\u060c \u0623\u0639\u0637\u062a \u0627\u0644\u0635\u064a\u063a\u0629 F3 \u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646-XL \u0639\u0646\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0628\u0646\u0633\u0628\u0629 7.5% \u0623\u0642\u0644 \u0632\u0645\u0646 \u062a\u0641\u062a\u062a\u060c \u0625\u0630 \u0644\u0648\u062d\u0638 \u062a\u0646\u0627\u0642\u0635\u064b\u0627 \u0641\u064a \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0645\u0639 \u062a\u0632\u0627\u064a\u062f \u062a\u0631\u0643\u064a\u0632 \u0646\u0633\u0628\u0629 \u0647\u0630\u0627 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0641\u062a\u062a \u0627\u0644\u0641\u0627\u0626\u0642 \u0648\u0647\u0630\u0627 \u0627\u0644\u062a\u0632\u0627\u064a\u062f \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 (P&lt;0.05) \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062c\u0645\u064a\u0639\u0647\u0627\u060c \u0648\u0647\u0630\u0627 \u064a\u0639\u0648\u062f \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0625\u0644\u0649 \u0627\u0644\u0622\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0639\u0645\u0644 \u0628\u0647\u0627 \u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646-XL \u0625\u0630 \u064a\u0632\u064a\u062f \u0645\u0646 \u0645\u0633\u0627\u0645\u064a\u0629 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0629 \u0644\u062f\u0649 \u062a\u0645\u0627\u0633\u0647\u0627 \u0645\u0639 \u0627\u0644\u0645\u0627\u0621\u060c \u0641\u0647\u0648 \u064a\u0639\u0645\u0644 \u0645\u0641\u062a\u062a\u064b\u0627 \u0641\u0627\u0626\u0642\u064b\u0627 \u0648\u0641\u0642 \u0622\u0644\u064a\u0629 \u0627\u0644\u0639\u0628\u0648\u0631 \u0627\u0644\u062a\u064a \u062a\u0633\u0645\u062d \u0644\u0644\u0642\u0648\u0629 \u0627\u0644\u0634\u0639\u0631\u064a\u0629 \u0644\u0644\u0645\u0633\u0627\u0645\u0627\u062a \u0628\u0642\u0628\u0637 \u0627\u0644\u0645\u0627\u0621 \u0628\u0639\u0645\u0642 \u0644\u062f\u0627\u062e\u0644 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0629 \u0648\u0628\u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u062a\u0641\u062a\u062a\u0647\u0627 \u0633\u0631\u064a\u0639\u064b\u0627 \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0628\u062d\u062b \u0646\u0634\u0631\u0647 Harada \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0639\u0627\u0645 2010<sup>(14)<\/sup>\u060c \u0639\u0644\u0649 \u062d\u064a\u0646 \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0645\u0646 \u0627\u0644\u0643\u0631\u0648\u0633 \u0643\u0627\u0631\u0645\u064a\u0644\u0648\u0632 \u0627\u0644\u062a\u064a \u0623\u0639\u0637\u062a \u0623\u0642\u0644 \u0632\u0645\u0646 \u062a\u0641\u062a\u062a \u0647\u064a 7.5% \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 F6\u060c \u0648\u0644\u0648\u062d\u0638 \u0623\u064a\u0636\u064b\u0627 \u062a\u0646\u0627\u0642\u0635\u064b\u0627 \u0641\u064a \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0645\u0639 \u062a\u0632\u0627\u064a\u062f \u062a\u0631\u0643\u064a\u0632 \u0646\u0633\u0628\u0629 \u0647\u0630\u0627 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0641\u062a\u062a \u0627\u0644\u0641\u0627\u0626\u0642 \u0648\u0647\u0630\u0627 \u0627\u0644\u062a\u0632\u0627\u064a\u062f \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 (P&lt;0.05) \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u0623\u064a\u0636\u064b\u0627.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211; \u0644\u0648\u062d\u0638 \u0623\u0646 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u062c\u0644 (\u063a\u0644\u064a\u0643\u0648\u0644\u0627\u062a \u0646\u0634\u0627\u0621 \u0635\u0648\u062f\u064a\u0648\u0645) \u0639\u0627\u0645\u0644\u064b\u0627 \u0645\u0641\u062a\u062a\u064b\u0627 \u0641\u0627\u0626\u0642\u064b\u0627 \u0623\u0628\u062f\u062a \u062a\u0632\u0627\u064a\u062f\u064b\u0627 \u0641\u064a \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0628\u062a\u0632\u0627\u064a\u062f \u062a\u0631\u0627\u0643\u064a\u0632 \u0647\u0630\u0627 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0641\u062a\u062a \u0625\u0630 \u0647\u0630\u0627 \u0627\u0644\u062a\u0632\u0627\u064a\u062f \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 (P&lt;0.05)\u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0639\u0632\u0649 \u0630\u0644\u0643 \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0642\u0633\u0627\u0648\u0629 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0636\u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0635\u064a\u063a \u0639\u0646 \u0645\u062b\u064a\u0644\u0627\u062a\u0647\u0627 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0623\u062e\u0631\u0649 \u0648\u0647\u0630\u0627 \u0645\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0628\u062d\u062b \u0646\u0634\u0631\u0647 Harada \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0639\u0627\u0645 2010 \u0639\u0646 \u0639\u0644\u0627\u0642\u0629 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0628\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0637\u0628\u0642 \u0639\u0644\u0649 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0628\u0639\u062b\u0631 \u0641\u064a \u0627\u0644\u0641\u0645<sup>(14)<\/sup>\u060c \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u0646\u0641\u0633\u0631 \u0627\u0644\u062a\u0632\u0627\u064a\u062f \u0627\u0644\u062d\u0627\u0635\u0644 \u0641\u064a \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0628\u0632\u064a\u0627\u062f\u0629 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u062c\u064a\u0644 \u0628\u062a\u0634\u0643\u0644 \u0637\u0628\u0642\u0629 \u0645\u0646 \u0627\u0644\u0647\u0644\u0627\u0645\u0629 \u0627\u0644\u0644\u0632\u062c\u0629 \u062d\u0648\u0644 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0644\u062f\u0649 \u062a\u0645\u0627\u0633\u0647\u0627 \u0645\u0639 \u0627\u0644\u0645\u0627\u0621 \u0648\u0627\u0644\u062a\u064a \u062a\u0634\u0643\u0644 \u062d\u0627\u062c\u0632\u064b\u0627 \u0644\u0632\u062c\u064b\u0627 \u062b\u062e\u064a\u0646\u064b\u0627 \u0623\u0645\u0627\u0645 \u0627\u062e\u062a\u0631\u0627\u0642 \u0648\u0633\u0637 \u0627\u0644\u062a\u0641\u062a\u062a \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0648\u0645\u0646 \u062b\u0645\u0651 \u062a\u0637\u0627\u0648\u0644 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a\u060c \u0648\u0647\u0630\u0627 \u064a\u062a\u0641\u0642 \u0645\u0639 \u0628\u062d\u062b \u0646\u0634\u0631\u0647 Setty \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0639\u0627\u0645 2008 <sup>(15)<\/sup>.<\/span><\/p>\n<div align=\"right\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-413 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-e1698430932708-300x193.png\" alt=\"\" width=\"659\" height=\"424\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-e1698430932708-300x193.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-e1698430932708-1024x658.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-e1698430932708-768x493.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-e1698430932708-1536x986.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/3-e1698430932708-2048x1315.png 2048w\" sizes=\"auto, (max-width: 659px) 100vw, 659px\" \/><\/div>\n<div align=\"right\"><\/div>\n<div align=\"right\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-409\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-300x193.png\" alt=\"\" width=\"716\" height=\"461\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-300x193.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-1024x660.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-768x495.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-1536x990.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/1-2048x1320.png 2048w\" sizes=\"auto, (max-width: 716px) 100vw, 716px\" \/><\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-414 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-e1698431136160-300x209.png\" alt=\"\" width=\"655\" height=\"456\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-e1698431136160-300x209.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-e1698431136160-1024x714.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-e1698431136160-768x535.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-e1698431136160-1536x1071.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/5-e1698431136160-2048x1428.png 2048w\" sizes=\"auto, (max-width: 655px) 100vw, 655px\" \/><span style=\"font-family: 'times new roman', times, serif;\">&#8211; \u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0632\u0645\u0646\u0629 \u0627\u0644\u062a\u0628\u0644\u0644 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u0633\u0639 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u064a\u0646 (3.17-20.76) \u062b\u0627\u0646\u064a\u0629\u060c \u0648\u0642\u062f \u0644\u0648\u062d\u0638 \u0648\u062c\u0648\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u0637\u0631\u062f\u064a \u0648\u0627\u0636\u062d \u0628\u064a\u0646 \u0632\u0645\u0646\u064a \u0627\u0644\u062a\u0641\u062a\u062a \u0648\u0627\u0644\u062a\u0628\u0644\u0644 \u0644\u0644\u0635\u064a\u063a \u0645\u0646 F1 \u0625\u0644\u0649 F3 \u0648\u0645\u0646 F4 \u0625\u0644\u0649 F6\u060c \u062a\u062a\u0641\u0642 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0645\u0639 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u064a \u062a\u0648\u0635\u0644 \u0625\u0644\u064a\u0647\u0627 P. Hooper \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0632\u0645\u0646\u064a \u0627\u0644\u062a\u0641\u062a\u062a \u0648\u0627\u0644\u062a\u0628\u0644\u0644<sup>(16)<\/sup>. \u0627\u0645\u062a\u0644\u0643\u062a \u0627\u0644\u0635\u064a\u063a\u0629 F3 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646-XL \u0628\u0648\u0635\u0641\u0647 \u0639\u0627\u0645\u0644\u064b\u0627 \u0645\u0641\u062a\u062a\u064b\u0627 \u0641\u0627\u0626\u0642\u064b\u0627 \u0623\u0642\u0644 \u0642\u064a\u0645\u0629 \u0632\u0645\u0646 \u062a\u0628\u0644\u0644 (3.17 \u062b\u0627\u0646\u064a\u0629) \u0628\u064a\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u0633\u0639 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062c\u0645\u064a\u0639\u0647\u0627\u060c \u0648\u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645\u0629 \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 (P&lt;0.05).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211; \u062a\u0631\u0627\u0648\u062d\u062a \u0646\u0633\u0628\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u0627\u0621 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u0628\u064a\u0646 71.2% \u0648146.4%\u060c \u0641\u0642\u062f \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u0627\u0621 \u0644\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u063a\u0644\u064a\u0643\u0648\u0644\u0627\u062a \u0635\u0648\u062f\u064a\u0648\u0645 \u0627\u0644\u0646\u0634\u0627\u0621 (Primojel) SSG \u0648\u0643\u0631\u0648\u0633 \u0643\u0627\u0631\u0645\u064a\u0644\u0648\u0632 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 SCC \u0623\u0639\u0644\u0649 \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646 CP\u060c \u0648\u0643\u0627\u0646\u062a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u063a\u0644\u064a\u0643\u0648\u0644\u0627\u062a \u0635\u0648\u062f\u064a\u0648\u0645 \u0627\u0644\u0646\u0634\u0627\u0621 SSG \u062a\u0645\u062a\u0644\u0643 \u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0646 \u0628\u064a\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0641\u064a \u0646\u0633\u0628\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u0627\u0621. \u0646\u0644\u0627\u062d\u0638 \u0639\u0646\u062f \u062a\u0632\u0627\u064a\u062f \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0641\u062a\u062a \u0627\u0644\u0641\u0627\u0626\u0642 \u062a\u062a\u0632\u0627\u064a\u062f \u0646\u0633\u0628\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u0627\u0621 \u0644\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0648\u0647\u0630\u0627 \u0645\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0628\u062d\u062b \u0646\u0634\u0631\u0647 SK Battu \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0639\u0627\u0645 2007 \u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0641\u062a\u062a \u0627\u0644\u0641\u0627\u0626\u0642 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0648\u0646\u0633\u0628\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u0627\u0621.<sup>(17)<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211; \u0627\u0646\u062a\u0642\u064a\u062a \u062b\u0644\u0627\u062b \u0635\u064a\u063a F3\u060c F6\u060c F7 \u0644\u0645\u062a\u0627\u0628\u0639\u0629 \u062f\u0631\u0627\u0633\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0648\u0643\u0627\u0646 \u0627\u0644\u0645\u0639\u064a\u0627\u0631 \u0627\u0644\u0623\u0633\u0627\u0633 \u0641\u064a \u0627\u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0647\u0648 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a\u060c \u0625\u0630 \u0627\u062e\u062a\u0628\u0631\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0648\u0627\u0644\u062a\u064a \u0623\u0639\u0637\u062a \u0623\u0642\u0644 \u0632\u0645\u0646 \u062a\u0641\u062a\u062a \u0645\u0646 \u0643\u0644 \u0645\u0641\u062a\u062a\u060c \u0625\u0630 \u0643\u0627\u0646 \u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0644\u0644\u0635\u064a\u063a F3\u060c F6\u060c F7 \u0647\u0648 6\u060c 8.2\u060c 18.1 \u062b\u0627\u0646\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0641\u062d\u0635 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 <\/strong><strong>Content uniformity test<\/strong><strong>:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0627\u0646\u062a \u0642\u064a\u0645 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u0645\u0642\u0628\u0648\u0644\u0629 \u062f\u0633\u062a\u0648\u0631\u064a\u064b\u0627 (85%-115%)\u060c \u0625\u0630 \u062a\u0631\u0627\u0648\u062d\u062a \u0627\u0644\u0642\u064a\u0645 \u0645\u0627 \u0628\u064a\u0646 (99.3%-102.6%) \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0645\u0627 \u0628\u064a\u0646 (99.1%-102.1%) \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 <\/strong><strong>Dissolution test<\/strong><strong>:<\/strong> <sup>(18)<\/sup><\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633 \u0645\u0646\u062d\u0646\u064a \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u063a F3\u060c F6\u060c F7 \u0627\u0644\u0645\u0646\u062a\u062e\u0628\u0629 \u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u0623\u062b\u064a\u0631 \u062a\u063a\u064a\u0631 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0641\u062a\u062a \u0627\u0644\u0641\u0627\u0626\u0642 \u0648\u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u062a\u062d\u0631\u0631 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a\u060c \u0648\u0630\u0644\u0643 \u0641\u064a (1\u060c 2\u060c 3\u060c 4\u060c 5\u060c 10) \u062f\u0642\u064a\u0642\u0629 \u0636\u0645\u0646 \u0648\u0633\u0637 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0633\u0641\u0627\u062a\u064a (pH= 6.8)\u060c \u0627\u0644\u0634\u0643\u0644\u064a\u0646 (10 \u064811).<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u062d\u062a\u064f\u0633\u0628 \u0627\u0644\u0632\u0645\u0646 \u0627\u0644\u0644\u0627\u0632\u0645 \u0644\u062a\u062d\u0631\u0631 80% \u0645\u0646 \u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0644\u0643\u0644 \u0635\u064a\u063a\u0629 \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u064a\u0627\u0646\u0627\u062a \u0648\u0645\u0646\u062d\u0646\u064a \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0647\u0630\u0647 \u0627\u0644\u0635\u064a\u063a.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0627\u0646 \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0648\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0627\u0644\u0645\u0646\u062a\u062e\u0628\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u0645\u0631\u062a\u0641\u0639\u064b\u0627\u060c \u0641\u0642\u062f \u062a\u062d\u0631\u0631 80% \u0645\u0646 \u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0641\u064a (1.33\u060c 1.9\u060c 2.75) \u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0641\u064a (2.25\u060c 2.63\u060c 2.95) \u062f\u0642\u064a\u0642\u0629 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0627\u0644\u0635\u064a\u063a F3\u060c F6\u060c F7 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628. \u0644\u0648\u062d\u0638 \u062a\u0634\u0627\u0628\u0647 \u062a\u062d\u0631\u0631 \u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0648\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0645\u0646 \u0643\u0644\u0627 \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 F3\u060c F6 \u0627\u0644\u0634\u0643\u0644\u064a\u0646 (7 \u06488)\u060c \u0625\u0630 \u064a\u0645\u0643\u0646 \u062a\u0641\u0633\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0628\u0623\u0646 \u0643\u0631\u0648\u0633 \u0643\u0627\u0631\u0645\u064a\u0644\u0644\u0648\u0632 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u064a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u062a\u0641\u062a\u064a\u062a \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0648\u064a\u0639\u0637\u064a \u0623\u062c\u0632\u0627\u0621 \u0623\u0635\u063a\u0631 \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0627\u0644\u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646\u060c \u0641\u064a \u062d\u064a\u0646 \u0627\u0644\u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646 \u064a\u0639\u0637\u064a \u0623\u062c\u0632\u0627\u0621 \u0623\u0643\u0628\u0631 \u0639\u0646\u062f \u062a\u0641\u062a\u062a\u0647 \u0648\u0644\u0643\u0646\u0647 \u064a\u062a\u0641\u062a\u062a \u0628\u0634\u0643\u0644 \u0623\u0633\u0631\u0639\u060c \u0644\u0630\u0627 \u0643\u0627\u0646\u062a \u0645\u0631\u062a\u0633\u0645\u0627\u062a \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0645\u062a\u0634\u0627\u0628\u0647\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646 \u0648\u0643\u0631\u0648\u0633 \u0643\u0627\u0631\u0645\u064a\u0644\u0644\u0648\u0632 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0643\u0639\u0627\u0645\u0644 \u0645\u0641\u062a\u062a \u0641\u0627\u0626\u0642\u060c \u0643\u0627\u0646 \u0645\u0639\u062f\u0644 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0643\u0644\u0627 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 F7 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u062c\u064a\u0644 \u0623\u0642\u0644 \u0645\u0645\u0627 \u0639\u0644\u064a\u0647 \u0641\u064a \u0627\u0644\u0635\u064a\u063a F3 \u0648F6\u060c \u064a\u0645\u0643\u0646 \u062a\u0641\u0633\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0628\u0623\u0646 \u063a\u0644\u064a\u0643\u0648\u0644\u0627\u062a \u0646\u0634\u0627\u0621 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 (\u0627\u0644\u0628\u0631\u064a\u0645\u0648\u062c\u064a\u0644) \u064a\u0641\u062a\u062a \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0628\u0634\u0643\u0644 \u0623\u0628\u0637\u0623 \u0628\u0625\u0639\u0637\u0627\u0621 \u062c\u0632\u064a\u0626\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u0627\u0644\u062d\u062c\u0645 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646 \u0648\u0643\u0631\u0648\u0633 \u0643\u0627\u0631\u0645\u064a\u0644\u0644\u0648\u0632 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645\u060c \u0647\u0630\u0627 \u064a\u062a\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0646\u0634\u0631\u0647\u0627Zaho \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0639\u0627\u0645 2005 \u0645.<sup>(19)<\/sup><\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0628\u062f\u062a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0627\u0644\u0645\u0646\u062a\u062e\u0628\u0629 F3\u060c F6\u060c F7 \u062a\u062d\u0631\u0631\u064b\u0627 \u0623\u0633\u0631\u0639 \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0630\u0644\u0643 \u0641\u064a \u0623\u0648\u0644 \u0623\u0631\u0628\u0639 \u062f\u0642\u0627\u0626\u0642 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u060c \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0639\u0632\u0649 \u0630\u0644\u0643 \u0625\u0644\u0649 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u064a\u0629 \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0625\u0630 \u0625\u0646 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u064a\u0635\u0646\u0651\u0641 \u0636\u0645\u0646 \u0627\u0644\u0635\u0646\u0641 \u0627\u0644\u0623\u0648\u0644 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 Class l\u060c \u0641\u0636\u0644\u064b\u0627 \u0639\u0646 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u064a\u0629 \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0636\u0645\u0646 \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 (\u0648\u0642\u0627\u0621 \u0641\u0633\u0641\u0627\u062a\u064a pH=6.8) \u0645\u0639 \u0623\u0646\u0647 \u064a\u0635\u0646\u0641 \u0636\u0645\u0646 \u0627\u0644\u0635\u0646\u0641 \u0627\u0644\u062b\u0627\u0646\u064a Class \u01c1 \u0648\u0641\u0642 \u0646\u0638\u0627\u0645 \u0627\u0644\u062a\u0635\u0646\u064a\u0641 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a \u0627\u0644\u062d\u064a\u0648\u064a.<sup>(20)<\/sup><\/span><\/li>\n<\/ul>\n<figure id=\"attachment_401\" aria-describedby=\"caption-attachment-401\" style=\"width: 483px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-401\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/10-300x100.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 10: \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a (F3, F6, F7)\" width=\"483\" height=\"161\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/10-300x100.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/10.jpg 639w\" sizes=\"auto, (max-width: 483px) 100vw, 483px\" \/><figcaption id=\"caption-attachment-401\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 10: \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a (F3, F6, F7)<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_402\" aria-describedby=\"caption-attachment-402\" style=\"width: 492px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-402\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/11-300x100.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 11: \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a (F3, F6, F7) \" width=\"492\" height=\"164\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/11-300x100.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/10\/11.jpg 639w\" sizes=\"auto, (max-width: 492px) 100vw, 492px\" \/><figcaption id=\"caption-attachment-402\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 11: \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a (F3, F6, F7)<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633\u062a \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0648\u0627\u0644\u062a\u062f\u0627\u062e\u0644\u0627\u062a \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0628\u062f\u0631\u0627\u0633\u0629 \u0643\u0644 \u0645\u0646 \u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0640 DSC \u0648\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0640 FTIR \u0627\u0644\u0646\u0627\u062a\u062c\u0629\u060c \u0648\u0645\u0646 \u062b\u0645 \u0623\u062c\u0631\u064a\u062a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u0631\u0639 \u0641\u064a \u0634\u0631\u0648\u0637 (40\u00b0C\/75% RH) \u0641\u064a 6 \u0623\u0634\u0647\u0631 \u0648\u0641\u0642 \u062a\u0648\u0635\u064a\u0627\u062a \u0627\u0644\u0640 ICH\u060c \u0648\u0628\u0639\u062f\u0647\u0627 \u062d\u064f\u0644\u0644\u062a \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0643\u0645\u064a\u064b\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 (HPLC)\u060c \u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u062c\u0648\u062f \u062a\u0646\u0627\u0641\u0631 \u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0628\u064a\u0646 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a\u060c \u0648\u0627\u0633\u062a\u0628\u0639\u062f \u0648\u062c\u0648\u062f \u0627\u0644\u062a\u0646\u0627\u0641\u0631 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0628\u0639\u062f \u0623\u0646 \u062f\u064f\u0631\u0633 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u0631\u0639 \u0644\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0648\u0645\u0632\u064a\u062c\u0647\u0645\u0627 \u0648\u0628\u0642\u0627\u0621 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0628\u062f\u062a \u0627\u0644\u0635\u064a\u063a\u0629 3F \u0646\u062a\u0627\u0626\u062c \u0645\u062b\u0627\u0644\u064a\u0629 \u0645\u0646 \u0625\u0630 \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629\u060c \u0625\u0630 \u0643\u0627\u0646 \u0632\u0645\u0646 \u0627\u0644\u062a\u0628\u0644\u0644 3.17 \u062b\u0627\u0646\u064a\u0629 \u0648\u0632\u0645\u0646 \u0627\u0644\u062a\u0641\u062a\u062a 6 \u062b\u0627\u0646\u064a\u0629\u060c \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0646\u062a\u0627\u0626\u062c \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0636\u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u0633\u0639 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0641\u0642\u062f \u062a\u0631\u0627\u0648\u062d\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0645\u0627 \u0628\u064a\u0646 (3%-102.6%) \u0648\u0644\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u0648\u0633\u0641\u0627\u062a \u0628\u064a\u0646 (99.1%-102.1%) \u0648\u0647\u064a \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u0646\u0635 \u0639\u0644\u064a\u0647\u0627 \u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a (85-115%).<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0648\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0648\u0644\u064a\u0629 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0645\u0634\u0627\u0631\u0643\u0629 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a\u060c \u0646\u0642\u062a\u0631\u062d \u0645\u062a\u0627\u0628\u0639\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u0639\u0636\u0648\u064a\u0629 \u0627\u0644\u062d\u064a\u0629 In-vivo \u0644\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0641\u064a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0646\u062a\u062e\u0628\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 F3\u060c F6\u060c F7 \u0648\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0644\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0648\u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u062a\u062d\u0633\u0646 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0644\u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0648\u0630\u0644\u0643 \u0639\u0646\u062f \u0635\u064a\u0627\u063a\u062a\u0647\u0645\u0627 \u0628\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0641\u062a\u062a \u0641\u064a \u0627\u0644\u0641\u0645\u060c \u0648\u0645\u0646 \u062b\u0645 \u0645\u0642\u0627\u0631\u0646\u0629 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u062f\u0631\u0627\u0633\u0629 \u0645\u062f\u0649 \u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0627 \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u062d\u0631\u0631 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c In-vitro.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0639\u0637\u0649 \u0627\u0644\u0645\u0641\u062a\u062a \u0627\u0644\u0641\u0627\u0626\u0642 \u0627\u0644\u0643\u0631\u0648\u0633 \u0628\u0648\u0641\u064a\u062f\u0648\u0646 \u0623\u0642\u0644 \u0632\u0645\u0646 \u062a\u0641\u062a\u062a \u0628\u064a\u0646 \u0627\u0644\u0635\u064a\u063a \u062c\u0645\u064a\u0639\u0647\u0627 \u0648\u0630\u0644\u0643 \u0639\u0646\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0628\u062a\u0631\u0643\u064a\u0632 7.5%.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0639\u0637\u0649 \u063a\u0644\u064a\u0643\u0648\u0644\u0627\u062a \u0646\u0634\u0627\u0621 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0623\u0643\u0628\u0631 \u0632\u0645\u0646 \u062a\u0641\u062a\u062a \u0628\u064a\u0646 \u0627\u0644\u0635\u064a\u063a \u062c\u0645\u064a\u0639\u0647\u0627 \u0648\u0630\u0644\u0643 \u0639\u0646\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0628\u062a\u0631\u0643\u064a\u0632 7.5%.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u062d\u062a\u064f\u0633\u0628 \u0627\u0644\u0632\u0645\u0646 \u0627\u0644\u0644\u0627\u0632\u0645 \u0644\u062a\u062d\u0631\u0631 80% \u0645\u0646 \u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0648\u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0644\u0643\u0644 \u0635\u064a\u063a\u0629 \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u064a\u0627\u0646\u0627\u062a \u0648\u0645\u0646\u062d\u0646\u064a \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0647\u0630\u0647 \u0627\u0644\u0635\u064a\u063a.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0627\u0646 \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0648\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0627\u0644\u0645\u0646\u062a\u062e\u0628\u0629 \u062c\u0645\u064a\u0639\u0647\u0627 \u0645\u0631\u062a\u0641\u0639\u064b\u0627\u060c \u0641\u0642\u062f \u062a\u062d\u0631\u0631 80% \u0645\u0646 \u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u0648\u062f\u0626\u064a\u0646 \u0641\u064f\u0633\u0641\u0627\u062a \u0641\u064a (1.33\u060c 1.9\u060c 2.75) \u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u0644\u0628\u064a\u0631\u0648\u0643\u0633\u064a\u0643\u0627\u0645 \u0641\u064a (2.25\u060c 2.63\u060c 2.95) \u062f\u0642\u064a\u0642\u0629 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0644\u0635\u064a\u063a F3\u060c F6\u060c F7 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628.<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u064a\u0645\u0643\u0646 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0639\u062f\u062f \u0645\u0646 \u0627\u0644\u0637\u0631\u0627\u0626\u0642 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0625\u0639\u0637\u0627\u0621 \u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0627\u0626\u064a \u062c\u0647\u0627\u0632\u064a \u0648\u0623\u0643\u062b\u0631 \u0627\u0644\u0637\u0631\u0627\u0626\u0642 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0644\u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621 \u0647\u064a \u0639\u0628\u0631 \u0627\u0644\u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645\u0648\u064a\u060c&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=113\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":398,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-134","volume-9","year-137"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=113"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/113\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/398"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}