{"id":119,"date":"2023-01-01T11:35:20","date_gmt":"2023-01-01T11:35:20","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=119"},"modified":"2024-07-19T14:07:03","modified_gmt":"2024-07-19T14:07:03","slug":"%d8%af%d8%b1%d8%a7%d8%b3%d8%a9-%d9%81%d9%8a-%d8%a7%d9%84%d8%b2%d8%ac%d8%a7%d8%ac-%d9%84%d8%aa%d9%88%d8%b2%d8%b9-%d8%a3%d8%a8%d8%b9%d8%a7%d8%af-%d8%ac%d8%b3%d9%8a%d9%85%d8%a7%d8%aa-%d8%a7%d9%84%d8%ac","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=119","title":{"rendered":"\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c \u0644\u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0644\u0635\u064a\u063a \u0645\u0637\u0648\u0631\u0629 \u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0631\u0630\u0627\u0630\u064a\u0629 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062c\u0631\u0639\u0629 \u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a (\u062f\u0631\u0627\u0633\u0629 \u062b\u0628\u0627\u062a \u0645\u064f\u0633\u0631\u0651\u0639)"},"content":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction:<\/span><\/strong><\/p>\n

\u064a\u0639\u062f \u0627\u0644\u0633\u0628\u064a\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0623\u062d\u062f \u0623\u0647\u0645 \u0637\u0631\u0642 \u0625\u064a\u062a\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621 \u0646\u0638\u0631\u0627\u064b \u0644\u0645\u0627 \u062a\u062a\u0645\u062a\u0639 \u0628\u0647 \u0627\u0644\u0631\u0626\u0629 \u0645\u0646 \u0645\u0633\u0627\u062d\u0629 \u0643\u0628\u064a\u0631\u0629 \u0645\u0639\u062f\u0629 \u0644\u0644\u0627\u0645\u062a\u0635\u0627\u0635 (100\u06452<\/sup>) , \u0643\u0645\u0627 \u0623\u0646\u0647 \u064a\u062c\u0646\u0628 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u0631\u0648\u0631 \u0627\u0644\u0643\u0628\u062f\u064a \u0627\u0644\u0623\u0648\u0644, \u0645\u0645\u0627 \u064a\u0633\u0627\u0639\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0627\u062c\u064a \u0628\u0623\u0642\u0644 \u062c\u0631\u0639\u0629 \u0645\u0645\u0643\u0646\u0629 \u0648\u0623\u0642\u0644 \u062a\u0623\u062b\u064a\u0631 \u062c\u0627\u0646\u0628\u064a \u0645\u0645\u0643\u0646.1, 2 <\/sup><\/span>\u0625\u0646 \u0623\u0648\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0627\u0631\u0630\u0627\u0630\u064a\u0629 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062c\u0631\u0639\u0629 Metered Dose Inhaler(MDI) \u064a\u0639\u0648\u062f \u0644\u0639\u0627\u0645 1956 , \u062d\u064a\u062b \u062a\u0645\u0643\u0646\u062a \u0645\u062e\u062a\u0628\u0631\u0627\u062a Riker \u0645\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 Medihaler \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0631\u0628\u0648 \u0648\u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f\u064a \u0627\u0644\u0645\u0632\u0645\u0646.3, 4 <\/sup><\/span>\u062a\u062a\u0623\u0644\u0641 \u0644\u0640MDI \u00a0\u0645\u0646 \u0645\u0643\u0648\u0646\u0627\u062a \u0639\u062f\u064a\u062f\u0629, \u0643\u0644 \u0645\u0646\u0647\u0627 \u0636\u0631\u0648\u0631\u064a \u0644\u062c\u0648\u062f\u0629 \u0639\u0645\u0644 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0627\u0631\u0630\u0627\u0630\u064a \u0648\u0647\u064a :<\/span><\/p>\n

-1 \u0627\u0644\u063a\u0627\u0632 \u0627\u0644\u062f\u0627\u0641\u0639 (propellant).<\/span><\/p>\n

-2 \u0627\u0644\u0648\u0639\u0627\u0621 \u0627\u0644\u062d\u0627\u0648\u064a (canister).<\/span><\/p>\n

-3\u0627\u0644\u0635\u0645\u0627\u0645 (valve).<\/span><\/p>\n

-4\u0627\u0644\u0645\u0634\u063a\u0644 ( actuator, adaptor, mouthpiece).<\/span><\/p>\n

-5\u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 ( formulation).5<\/sup><\/span><\/p>\n

\u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u063a\u0627\u0632 \u0627\u0644\u062f\u0627\u0641\u0639 \u0627\u0644\u0645\u0643\u0648\u0646 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0644\u0644\u0640 MDI, \u0648\u0644\u0642\u062f \u062a\u0637\u0648\u0631 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u062a\u0637\u0648\u0631\u0627\u064b \u0643\u0628\u064a\u0631\u0627\u064b, \u062d\u064a\u062b \u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0641\u064a \u0627\u0644\u0628\u062f\u0627\u064a\u0629 \u063a\u0627\u0632\u0627\u062a Chloro Flouro Carbon (CFC), \u0648\u0627\u0644\u062a\u064a \u062a\u0645 \u0633\u062d\u0628\u0647\u0627 \u0646\u0647\u0627\u0626\u064a\u0627\u064b \u0645\u0646 \u0627\u0644\u0623\u0633\u0648\u0627\u0642 \u0628\u0639\u062f \u0635\u062f\u0648\u0631 \u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644 Monterial \u0639\u0627\u0645 1978 \u0646\u062a\u064a\u062c\u0629 \u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a\u0647\u0627 \u0627\u0644\u0636\u0627\u0631\u0629 \u0639\u0644\u0649 \u0637\u0628\u0642\u0629 \u0627\u0644\u0623\u0648\u0632\u0648\u0646.6, 7 <\/sup><\/span>\u062a\u0636\u0627\u0641\u0631\u062a \u062c\u0647\u0648\u062f \u0627\u0644\u0634\u0631\u0643\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0641\u064a \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u063a\u0627\u0632\u0627\u062a \u0628\u062f\u064a\u0644\u0629 \u0635\u062f\u064a\u0642\u0629 \u0644\u0644\u0628\u064a\u0626\u0629, \u0648\u062a\u0645 \u0627\u0644\u062a\u0648\u0635\u0644 \u0625\u0644\u0649 \u0623\u0646 \u063a\u0627\u0632\u0627\u062a\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0Hydro Flouro Alkane(HFA-134 \/HFA227) \u0628\u062f\u0627\u0626\u0644 \u062c\u064a\u062f\u0629 \u00a0\u0644\u0644\u0640 CFC \u00a08<\/sup>. <\/span>\u0625\u0646 \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u0646 CFC \u0625\u0644\u0649 HFA \u062a\u0637\u0644\u0628 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u0627\u0644\u062e\u0648\u0627\u0635 \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0644\u0643\u0644 \u0645\u0646\u0647\u0645\u0627, \u0645\u0645\u0627 \u0623\u062f\u0649 \u0625\u0644\u0649 \u0636\u0631\u0648\u0631\u0629 \u0625\u062c\u0631\u0627\u0621 \u0628\u0639\u0636 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0647\u0646\u062f\u0633\u064a \u0644\u0644\u0640 MDI \u0643\u0627\u0644\u0635\u0645\u0627\u0645 \u0648 \u0627\u0644\u0645\u0634\u063a\u0644 (actuator), \u0648\u0636\u0631\u0648\u0631\u0629 \u0625\u062c\u0631\u0627\u0621 \u062a\u0639\u062f\u064a\u0644 \u0641\u064a \u0627\u0644\u0635\u064a\u0627\u063a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u064a\u0646\u0629 \u0648\u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u0633\u0648\u0627\u063a\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0630\u0648\u0627\u0628\u0629 \u0636\u0645\u0646 \u0627\u0644\u063a\u0627\u0632 \u0627\u0644\u062f\u0627\u0641\u0639 \u0627\u0644\u062c\u062f\u064a\u062f. 6 <\/sup><\/span>\u062a\u0639\u062a\u0628\u0631 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u0637\u062d (Surfactants) \u0645\u062b\u0644sorbitan trioleate \u00a0\u0648\u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a oleic acid \u0648 lecithin \u0645\u0646 \u0623\u0647\u0645 \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u0635\u064a\u0627\u063a\u0629 MDI, \u062d\u064a\u062b \u062a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0647\u0627\u0645\u0627\u064b \u0641\u064a \u0645\u0646\u0639 \u062a\u0634\u0643\u0644 \u0627\u0644\u062a\u0643\u062a\u0644\u0627\u062a(agglomerates) \u0648\u0645\u0646\u0639 \u0638\u0627\u0647\u0631\u0629 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0628\u0644\u0648\u0631\u064a (crystal growth) \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0644\u062f\u0648\u0631\u0647\u0627 \u0627\u0644\u0645\u0632\u0644\u0642 \u0644\u0644\u0635\u0645\u0627\u0645 (lubricant) \u0644\u0643\u0646\u0647\u0627 \u0630\u0627\u062a \u0627\u0646\u062d\u0644\u0627\u0644\u064a\u0629 \u0645\u0646\u062e\u0641\u0636\u0629 \u0636\u0645\u0646 \u063a\u0627\u0632\u0627\u062a HFAs \u00a0\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0640 CFCs \u0648\u064a\u0645\u0643\u0646 \u062a\u062d\u0633\u064a\u0646 \u0647\u0630\u0647 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u064a\u0629 \u0628\u0625\u0636\u0627\u0641\u0629 \u0645\u062d\u0644\u0627\u062a \u0645\u0633\u0627\u0639\u062f\u0629 (co-solvent) \u0645\u062b\u0644 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644. 9-11<\/sup><\/span><\/p>\n

\u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0647\u0648 \u0623\u0643\u062b\u0631 \u0627\u0644\u0645\u062d\u0644\u0627\u062a \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0634\u064a\u0648\u0639\u0627\u064b \u0641\u064a MDI \u0648\u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0623\u0646 \u0646\u0633\u0628\u0629 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 \u064a\u062c\u0628 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0645\u062f\u0631\u0648\u0633\u0629 \u0628\u062f\u0642\u0629 \u0648\u0625\u0646 \u0623\u064a \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u064a\u0646\u062c\u0645 \u0639\u0646\u0647 \u0646\u0642\u0635\u0627\u0646 \u0641\u064a \u0643\u062b\u0627\u0641\u0629 \u0648\u0636\u063a\u0637 \u0628\u062e\u0627\u0631 \u0627\u0644\u0635\u064a\u063a\u0629 \u0645\u0645\u0627 \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0627\u0631\u0630\u0627\u0630, \u0648\u064a\u0624\u062f\u064a \u0644\u062a\u0634\u0643\u0644 \u0642\u0637\u064a\u0631\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u0627\u0644\u062d\u062c\u0645 \u062a\u062a\u0648\u0632\u0639 \u0641\u064a \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u0628\u0644\u0639\u0648\u0645\u064a \u0627\u0644\u0641\u0645\u0648\u064a 12<\/sup>, \u0643\u0645\u0627 \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0627\u0644\u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0627\u0644\u0637\u0639\u0645 \u0627\u0644\u0633\u064a\u0626 \u0644\u0644\u0640 (MDI)13<\/sup> , \u0648\u062a\u0639\u0632\u0649 \u0625\u0644\u064a\u0647 \u0645\u0634\u0643\u0644\u0629 \u0627\u0644\u0633\u0639\u0627\u0644 \u0628\u0639\u062f \u062a\u0646\u0627\u0648\u0644 \u0627\u0644\u062c\u0631\u0639\u062914<\/sup>, \u0648\u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u062d\u0635 \u0627\u0644\u0643\u062d\u0648\u0644 \u062e\u0644\u0627\u0644 (1-3) \u062f\u0642\u064a\u0642\u0629 \u0645\u0646 \u062a\u0646\u0627\u0648\u0644 \u0627\u0644\u062c\u0631\u0639\u062915<\/sup>. <\/span>\u062a\u0639\u062a\u0628\u0631 MDI \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0646\u0627\u0647\u0636 2\u00df \u0642\u0635\u064a\u0631 \u0627\u0644\u0623\u0645\u062f \u0627\u0644\u062e\u0637 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0627\u0644\u0623\u0648\u0644 \u0641\u064a \u062a\u062f\u0628\u064a\u0631 \u0646\u0648\u0628\u0627\u062a \u0627\u0644\u0631\u0628\u0648 \u0627\u0644\u062d\u0627\u062f\u0629 \u0648\u0647\u064a \u0645\u0633\u0648\u0642\u0629 \u0628\u0634\u0643\u0644 \u0645\u0639\u0644\u0642\u0627\u062a.16 <\/sup><\/span>\u0625\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a 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\u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0635\u064a\u063a \u062b\u0627\u0628\u062a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645oleic acid \u00a0, \u0648 Miglyol840 , \u0648 transcutol , \u0648\u0644\u0643\u0646 \u0623\u064a \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0635\u064a\u063a \u0644\u0645 \u062a\u0633\u0648\u0642 \u0628\u0639\u062f18<\/sup>. <\/span>\u0643\u0645\u0627 \u0627\u062a\u062c\u0647 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0627\u0644\u0649 \u0647\u0646\u062f\u0633\u0629 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u062d\u064a\u062b \u0646\u062c\u062d Arafa et al<\/em> \u00a0\u0645\u0646 \u062a\u062d\u0636\u064a\u0631 MDI \u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0628\u0634\u0643\u0644 niosomes 19<\/sup>, \u0643\u0645\u0627 \u062a\u0645\u0643\u0646 Dellamary et al<\/em> \u0645\u0646 \u00a0\u062a\u062d\u0636\u064a\u0631 \u062c\u0633\u064a\u0645\u0627\u062a \u0645\u0633\u0627\u0645\u064a\u0629 \u0645\u062d\u0628\u0629 \u0644\u0644\u062f\u0633\u0645 (pulmosphere) \u0644\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0648\u0644\u0643\u0646 \u0647\u0630\u0647 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0645\u0627\u0632\u0627\u0644\u062a \u0642\u064a\u062f \u0627\u0644\u062a\u0637\u0648\u064a\u0631 , \u0648\u0644\u0645 \u062a\u062d\u0635\u0644 \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0627\u062a \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0644\u0637\u0631\u062d\u0647\u0627 \u0641\u064a \u0627\u0644\u0623\u0633\u0648\u0627\u064220<\/sup>. <\/span>\u0633\u064a\u062a\u0645 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0636\u064a\u0631 \u0635\u064a\u063a \u0644\u0640 MDI \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062d\u0644\u0627\u062a \u0645\u0633\u0627\u0639\u062f\u0629 \u0628\u062f\u064a\u0644\u0629 \u0644\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0645\u062b\u0644 PEG400 , \u0648 Isopropyl Myreistate (IPM) , \u0648\u0645\u0631\u0627\u0642\u0628\u0629 \u062c\u0648\u062f\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c \u00a0in-vitro<\/em>\u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0627\u0644\u0623\u0645\u062b\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a Aerodynamic particle size distribution (APSD) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 Next generation cascade impactor (NGI) \u0648\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0627 \u0627\u0644\u0645\u062d\u0644 \u0641\u064a \u062a\u0637\u0648\u064a\u0631 \u0635\u064a\u063a\u0629 \u062c\u062f\u064a\u062f\u0629 \u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0628\u0627\u062a\u0628\u0627\u0639\u00a0 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0635\u064a\u0627\u063a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u0643\u0625\u0636\u0627\u0641\u0629 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0643\u0639\u0627\u0645\u0644 \u0641\u0639\u0627\u0644 \u0639\u0644\u0649 \u0627\u0644\u0633\u0637\u062d \u0623\u0648 \u0625\u0636\u0627\u0641\u0629 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(PVP k-30) \u0643\u0639\u0627\u0645\u0644 \u0645\u0639\u0644\u0642 \u0648 \u0627\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u062b\u0628\u0627\u062a \u0645\u0633\u0631\u0639 (accelerated) \u0636\u0645\u0646 \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 (40\u00b0C\/75%RH)\u00a0 \u0644\u062a\u062d\u062f\u064a\u062f \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u062c\u062f\u064a\u062f\u0629\u00a0 \u062e\u0644\u0627\u0644 \u0627\u0644\u0646\u0642\u0627\u0637 (0-3-6 ) \u0623\u0634\u0647\u0631 \u0648 \u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f(control) \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0628\u0646\u0633\u0628\u0629 (10%). <\/span>\u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u062c\u0647\u0627\u0632 NGI \u0627\u0644\u0638\u0627\u0647\u0631 \u0641\u064a \u0627\u0644\u0634\u0643\u0644(1) \u0644\u062f\u0631\u0627\u0633\u0629 APSD , \u0648\u0647\u0648 \u064a\u062a\u0623\u0644\u0641 \u0645\u0646 \u0633\u0628\u0639 \u0645\u0631\u0627\u062d\u0644 \u0648 \u0641\u0644\u062a\u0631 \u0646\u0647\u0627\u0626\u064a , \u062d\u064a\u062b \u064a\u0639\u062a\u0628\u0631 NGI \u062c\u0647\u0627\u0632\u0627\u064b \u0645\u062d\u0627\u0643\u064a\u0627\u064b \u0644\u0628\u0646\u0649 \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0648\u0645\u0646\u0627\u0633\u0628\u0627\u064b \u0644\u0644\u0639\u0645\u0644 \u0628\u0645\u0639\u062f\u0644 \u062a\u062f\u0641\u0642 \u0647\u0648\u0627\u0621 \u0645\u0646 (15-100 litre\/min) 21<\/sup>, \u0648\u0647\u0648 \u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0633\u0627\u062a\u064a\u0631, \u0648\u0647\u064a\u0626\u0627\u062a \u0627\u0644\u0631\u0642\u0627\u0628\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0643\u0641\u062d\u0635 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c (in-vitro<\/em>) 22<\/sup> , \u062d\u064a\u062b \u064a\u0639\u0628\u064e\u0631 \u0639\u0646APSD \u0628\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0623\u0647\u0645\u0647\u0627 \u0627\u0644\u0642\u0637\u0631 \u0627\u0644\u0647\u0648\u0627\u0626\u064a \u0627\u0644\u0648\u0633\u0637\u064a \u0644\u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a Mass median aerodynamic diameter(MMAD) , \u0648 \u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649\u00a0 \u0625\u0646 \u0642\u064a\u0645 MMAD \u064a\u062c\u0628 \u0623\u0646 \u062a\u0643\u0648\u0646 (1-5\u00b5) \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0641\u0636\u0644 \u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0627\u0626\u064a, \u0623\u064a \u0623\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0630\u0627\u062a (MMAD\u02c35\u00b5) \u062a\u0639\u0644\u0642 \u0641\u064a \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u0628\u0644\u0639\u0648\u0645\u064a \u0627\u0644\u0641\u0645\u0648\u064a, \u0628\u064a\u0646\u0645\u0627 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0630\u0627\u062a (MMAD \u02c2 1 \u00b5) \u062a\u062e\u0631\u062c \u0645\u0639 \u0647\u0648\u0627\u0621 \u0627\u0644\u0632\u0641\u064a\u0631 \u062f\u0648\u0646 \u0623\u0646 \u062a\u062d\u062f\u062b \u0623\u064a \u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0627\u0626\u064a, \u0643\u0645\u0627 \u064a\u0639\u0628\u0631 \u0623\u064a\u0636\u0627\u064b \u0639\u0646 APSD \u0628\u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0627\u0644\u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0631\u0626\u0629Fine Particle Mass (FPM) \u0623\u064a \u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0630\u0627\u062a MMAD \u0645\u0646 (1-5\u00b5) \u0643\u0645\u0627 \u064a\u0639\u0628\u0651\u0631 \u0623\u064a\u0636\u0627\u064b \u0639\u0646 \u0641\u062d\u0635 APSD \u0628\u0640\u0646\u0633\u0628\u0629 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0631\u0626\u0629 Fine Particle Fraction(FPF) , \u0648\u0647\u064a \u0646\u0633\u0628\u0629 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0630\u0627\u062a MMAD \u0645\u0646 (1-5\u00b5) \u0645\u0646 \u0625\u062c\u0645\u0627\u0644\u064a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0648 \u0645\u0646 \u0636\u0645\u0646 \u0627\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u064a\u0647\u0627 \u0645\u0646 \u0641\u062d\u0635 APSD \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0647\u0646\u062f\u0633\u064a Geometric Standard Deviation (GSD).23<\/sup><\/span><\/p>\n

\"\u0627\u0644\u0634\u0643\u0644
\u0627\u0644\u0634\u0643\u0644 \u0631\u0642\u0645 (1): \u0645\u0631\u0627\u062d\u0644 \u062c\u0647\u0627\u0632 NGI \u0648\u0628\u0646\u0649 \u0627\u0644\u0633\u0628\u064a\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u0647\u0627<\/span><\/figcaption><\/figure>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong>Materials and Methods <\/strong><\/span><\/p>\n

    \n
  • \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629<\/strong><\/span><\/li>\n
  • \u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0627\u0644\u0639\u064a\u0627\u0631\u064a BP302 (99.8%)\u0635\u0646\u0639 \u0634\u0631\u0643\u0629 Merck \u0623\u0644\u0645\u0627\u0646\u064a\u0627, \u0648 \u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0645\u0627\u062f\u0629 \u0623\u0648\u0644\u064a\u0629 \u0630\u0627\u062a \u0623\u0628\u0639\u0627\u062f (95% = 4.31\u00b5m) \u0635\u0646\u0639 \u0634\u0631\u0643\u0629 Jayco (63%) \u0631\u0642\u0645 \u0637\u0628\u062e\u0629 SS\/161\/17-18 \u0627\u0644\u0647\u0646\u062f.<\/span><\/li>\n
  • PEG400 \u0635\u0646\u0639 SHANDONG \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 8734-37 \u0627\u0644\u0635\u064a\u0646, \u0648Ethanol (99.9%) \u0635\u0646\u0639 Sasol Chemicals \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 92039194 \u062c\u0646\u0648\u0628 \u0625\u0641\u0631\u064a\u0642\u064a\u0627, \u0648 Oleic Acid \u0635\u0646\u0639 Quimica \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 TQ0338 \u0627\u0644\u0645\u0643\u0633\u064a\u0643, \u0648HFA134a \u0635\u0646\u0639 Zephex \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 BR16442-8 \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0645\u062a\u062d\u062f\u0629.<\/span><\/li>\n
  • \u0639\u0628\u0648\u0627\u062a \u0645\u0639\u062f\u0646\u064a\u0629 \u0645\u0635\u0646\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645 \u0635\u0646\u0639 PRESSPART \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 PPB0021987 \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0648\u0627\u0644\u0635\u0645\u0627\u0645 \u0645\u0639\u0627\u064a\u0631 \u0627\u0644\u062c\u0631\u0639\u0629 \u0633\u0639\u0629 50\u00b5L \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 \/00242091 \u0648\u0627\u0644\u062d\u0627\u0636\u0646\u0629 \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 Coaster71298\/001 \u0635\u0646\u0639 \u0625\u064a\u0637\u0627\u0644\u064a\u0627.<\/span><\/li>\n
  • \u0639\u0628\u0648\u0627\u062a PET vial-MRX002 \u0635\u0646\u0639 Merxin \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 MR547 \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0645\u062a\u062d\u062f\u0629.<\/span><\/li>\n
  • Lichrosolv\u00ae (Methanol) (99.8%) \u0648(98.0%) Emsure\u00ae (Ammonium Acetate) \u0635\u0646\u0639 Merk \u0623\u0644\u0645\u0627\u0646\u064a\u0627.<\/span><\/li>\n
  • \u0627\u0644\u0623\u062c\u0647\u0632\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629<\/strong><\/span><\/li>\n<\/ul>\n

    \u062a\u0645 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0643\u0631\u0648\u0645\u0627\u062a\u0648\u063a\u0631\u0627\u0641\u064a\u0627 \u0627\u0644\u0633\u0627\u0626\u0644\u0629 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u062f\u0627\u0621 \u0646\u0648\u0639 MERCK-HITACHI LaChrom L-7000 series \u0635\u0646\u0639 \u0623\u0644\u0645\u0627\u0646\u064a\u0627 , \u0648\u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a Next Generation Cascade Impactor \u0635\u0646\u0639 Copley \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0645\u062a\u062d\u062f\u0629 ,\u0648\u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 sonicator \u0635\u0646\u0639 Liarre \u0625\u064a\u0637\u0627\u0644\u064a\u0627 ,\u0648\u062d\u062c\u0631\u0629 \u062b\u0628\u0627\u062a \u0646\u0648\u0639 Memmert M-750 \u0635\u0646\u0639 \u0623\u0644\u0645\u0627\u0646\u064a\u0627 ,\u0648\u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633(0.0001\u063a) \u0646\u0648\u0639 Precisa XB220A \u0635\u0646\u0639 \u0633\u0648\u064a\u0633\u0631\u0627.<\/span><\/p>\n

      \n
    • \u0627\u0644\u0637\u0631\u0642<\/strong><\/span><\/li>\n<\/ul>\n

      1-3- \u0634\u0631\u0648\u0637 \u0627\u0644\u0643\u0631\u0648\u0645\u0627\u062a\u0648\u063a\u0631\u0627\u0641\u064a\u0627 \u0627\u0644\u0633\u0627\u0626\u0644\u0629 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u062f\u0627\u0621<\/strong><\/span><\/p>\n

      \u062a\u0645\u062a \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0643\u0631\u0648\u0645\u0627\u062a\u0648\u063a\u0631\u0627\u0641\u064a\u0627 \u0627\u0644\u0633\u0627\u0626\u0644\u0629 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u062f\u0627\u0621 (HPLC) \u0627\u0644\u0648\u0627\u0631\u062f\u0629 \u0636\u0645\u0646 \u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0628\u0631\u064a\u0637\u0627\u0646\u064a (BP2013), \u062d\u064a\u062b \u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0645\u0648\u062f Lichrocart\u00ae100RP-18(5\u00b5mx10-cm) \u0648\u0637\u0648\u0631 \u0645\u062a\u062d\u0631\u0643 \u0645\u0643\u0648\u0646 \u0645\u0646\u00a0 \u0645\u0632\u064a\u062c \u00a0(Methanol: Amonioum Acetate 0.1%W\/ V)( 800ml:225ml), \u0643\u0645\u0627 \u062a\u0645 \u0636\u0628\u0637 \u0645\u0639\u062f\u0644 \u0627\u0644\u062a\u062f\u0641\u0642 2ml\/minute \u0648\u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0643\u0634\u0641 \u0639\u0644\u0649 276 nm \u0648\u062a\u0645 \u062d\u0642\u0646 \u0639\u064a\u0646\u0629 20\u00b5l \u0639\u0646\u062f \u0643\u0644 \u062a\u062d\u0644\u064a\u0644.<\/span><\/p>\n

      2-3- \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0639\u0645\u0644 <\/strong><\/span><\/p>\n

      1-2-3- \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629:<\/strong><\/span><\/p>\n

        \n
      • \u062a\u062d\u062a\u0648\u064a \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f S-ETOH \u0639\u0644\u0649 \u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0648 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0648 \u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0648 HFA134a.<\/span><\/li>\n
      • \u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 PEG400 \u0648IPM \u0643\u0645\u062d\u0644\u0627\u062a \u0645\u0633\u0627\u0639\u062f\u0629 \u0645\u0642\u062a\u0631\u062d\u0629 \u0628\u062f\u064a\u0644\u0629 \u0644\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0641\u064a \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f.<\/span><\/li>\n
      • \u062a\u0645 \u062a\u0639\u0628\u0626\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 (1-3-5%) \u0645\u0646 \u0627\u0644\u0645\u062d\u0644\u0627\u062a \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0627\u0644\u0628\u062f\u064a\u0644\u0629 PEG400 \u0648 IPM\u00a0\u00a0\u00a0 \u0648 \u0646\u0633\u0628 \u062b\u0627\u0628\u062a\u0629 \u0645\u0646 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0648 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a(5 \u0639\u0628\u0648\u0627\u062a \u0645\u0639\u062f\u0646\u064a\u0629 \u0648 \u0639\u0628\u0648\u062a\u064a\u0646 PET).<\/span><\/li>\n
      • \u062a\u0645 \u062a\u0639\u0628\u0626\u0629 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f S-ETOH \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 (10%) \u0645\u0646 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 (5 \u0639\u0628\u0648\u0627\u062a \u0645\u0639\u062f\u0646\u064a\u0629 \u0648 \u0639\u0628\u0648\u062a\u0627\u0646 (PET.<\/span><\/li>\n
      • \u0643\u0644 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0639\u0628\u0623\u0629 \u062a\u062d\u0631\u0631(108mcg) \u0628\u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0648\u0627\u062d\u062f\u0629 \u0648 \u0643\u0644 \u0639\u0628\u0648\u0629 \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 200 \u062c\u0631\u0639\u0629.<\/span><\/li>\n
      • \u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0639\u064a\u0627\u0646\u064a (visual observation) \u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0645\u0646 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f.<\/span><\/li>\n
      • \u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0628\u0648\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u062a\u062d\u062f\u064a\u062f \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a APSD \u0644\u0644\u0639\u0628\u0648\u0627\u062a \u0627\u0644\u062a\u064a \u0627\u062c\u062a\u0627\u0632\u062a \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0639\u064a\u0627\u0646\u064a \u0644\u064a\u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0627\u0644\u0623\u0645\u062b\u0644 (\u0639\u062f\u062f \u0627\u0644\u0639\u0628\u0648\u0627\u062a = 5).<\/span><\/li>\n
      • \u062a\u0645 \u062a\u0639\u0628\u0626\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0646\u0633\u0628\u0629 \u062b\u0627\u0628\u062a\u0629 \u0645\u0646 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0648\u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0627\u0644\u062c\u062f\u064a\u062f \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0648\u0627\u0645\u0644 \u062a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0639\u0644\u0642 \u0643\u062d\u0645\u0636 \u0632\u064a\u062a \u0648 PVP-k30 .<\/span><\/li>\n
      • \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u062b\u0628\u0627\u062a \u0645\u0633\u0631\u0639 (40\u00b0C\/75%RH) \u0648 \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0644\u0644\u0639\u0628\u0648\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 NGI \u062e\u0644\u0627\u0644 \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 (0,3,6 \u0623\u0634\u0647\u0631) \u0648 \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f S-ETOH .<\/span><\/li>\n<\/ul>\n

        2-2-3- \u0641\u062d\u0635 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 <\/strong>NGI<\/strong><\/span><\/p>\n

          \n
        • \u0636\u0628\u0637 \u0645\u0639\u062f\u0644 \u062a\u062f\u0641\u0642 \u0627\u0644\u0647\u0648\u0627\u0621 \u0644\u062c\u0647\u0627\u0632 NGI \u0639\u0644\u0649 30 \u0644\u062a\u0631\/ \u062f\u0642\u064a\u0642\u0629 \u0648\u0647\u0648 \u0627\u0644\u0645\u0639\u062f\u0644 \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0623\u0641\u0636\u0644 \u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0627\u0626\u064a \u0644\u0644\u0640MDI .<\/span><\/li>\n
        • \u0625\u062c\u0631\u0627\u0621 \u0639\u0645\u0644\u064a\u0629 \u062a\u062d\u0636\u064a\u0631 \u0644\u0644\u0639\u0628\u0648\u0629(priming) \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062d\u0631\u064a\u0631 \u0623\u0631\u0628\u0639 \u062c\u0631\u0639\u0627\u062a \u0641\u064a \u0627\u0644\u0647\u0648\u0627\u0621 \u0648\u0641\u0642 \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u0648\u0627\u0631\u062f\u0629 \u062d\u0633\u0628 \u0643\u0644 \u062a\u062d\u0644\u064a\u0644.<\/span><\/li>\n
        • \u062a\u062d\u0631\u064a\u0631 \u0639\u0634\u0631 \u0628\u062e\u0627\u062a \u0645\u0646 \u0639\u0628\u0648\u0629 MDI \u062f\u0627\u062e\u0644 \u062c\u0647\u0627\u0632 NGI. .<\/span><\/li>\n
        • \u063a\u0633\u0644 \u0643\u0644 \u0645\u0631\u062d\u0644\u0629 \u0645\u0646 \u0645\u0631\u0627\u062d\u0644 \u062c\u0647\u0627\u0632 NGI \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 5ml \u0645\u0646 \u0627\u0644\u0648\u0642\u0627\u0621 \u0648 10\u0645\u0644 \u0645\u064a\u062a\u0627\u0646\u0648\u0644.<\/span><\/li>\n
        • \u0648\u0636\u0639 \u0627\u0644\u0627\u0631\u0644\u0646\u0645\u0627\u064a\u0631 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0645\u062f\u0629 \u0639\u0634\u0631 \u062f\u0642\u0627\u0626\u0642.<\/span><\/li>\n
        • \u0646\u0642\u0644 \u0627\u0644\u0639\u064a\u0646\u0629 \u0627\u0644\u0649 \u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u0629 50ml \u0648\u062b\u0645 \u0625\u0643\u0645\u0627\u0644 \u0625\u0644\u0649 \u062e\u0637 \u0627\u0644\u0639\u064a\u0627\u0631 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u064a\u062a\u0627\u0646\u0648\u0644.<\/span><\/li>\n
        • \u0648\u0636\u0639 \u0627\u0644\u0628\u0627\u0644\u0648\u0646 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0645\u062f\u0629 \u062e\u0645\u0633 \u062f\u0642\u0627\u0626\u0642 \u062b\u0645 \u0646\u0642\u0644 \u0627\u0644\u0639\u064a\u0646\u0629 \u0625\u0644\u0649 \u0641\u064a\u0627\u0644 \u0627\u0644\u062d\u0642\u0646 \u0645\u0639 \u0627\u0644\u0639\u0646\u0648\u0646\u0629.<\/span><\/li>\n
        • \u062d\u0642\u0646 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0639\u064a\u0627\u0631\u064a \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a \u0644\u0646\u062d\u0635\u0644 \u0639\u0644\u0649 \u0645\u0644\u0627\u0621\u0645\u0629 \u0627\u0644\u062c\u0647\u0627\u0632.<\/span><\/li>\n
        • \u062d\u0642\u0646 20 \u00b5l \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0629 \u0648 \u062d\u0633\u0627\u0628 \u0627\u0644\u062a\u0631\u0643\u064a\u0632.<\/span><\/li>\n<\/ul>\n

          3<\/strong>-3- \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 <\/strong><\/span><\/p>\n

          \u062a\u0645 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c JMP 13.2 \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062f\u0644\u0627\u0644\u0629 (\u03b1 =0.05) \u0648\u0641\u0642 Comparative each pair (t-Student).<\/span><\/p>\n

          \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629:<\/strong><\/span><\/p>\n

          \u062a\u0645 \u062a\u062d\u0636\u064a\u0631 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062fS-ETOH , \u0648\u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 PEG400 \u0648 IPM \u0643\u0645\u062d\u0644\u0627\u062a \u0645\u0633\u0627\u0639\u062f\u0629 \u0628\u062f\u064a\u0644\u0629 \u0644\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062b\u0628\u064a\u062a \u0643\u0627\u0641\u0629 \u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u064a\u063a\u0629, \u0648\u0627\u0633\u062a\u0628\u062f\u0627\u0644 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0628\u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u062a\u0632\u0627\u064a\u062f\u0629 (1-3-5%) \u0645\u0646 PEG400 \u0648 IPM. <\/span>\u0643\u0645\u0627 \u062a\u0645\u062a \u0645\u0631\u0627\u0642\u0628\u0629 \u0639\u0628\u0648\u0627\u062a PET \u0627\u0644\u0645\u0639\u0628\u0623\u0629 \u0639\u064a\u0627\u0646\u064a\u0627\u064b \u0648\u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 S-ETOH(10%) \u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u062a\u0643\u062a\u0644\u0627\u062a \u0635\u0639\u0628\u0629 \u0627\u0644\u0628\u0639\u062b\u0631\u0629 \u0623\u0648 \u0627\u0644\u062a\u0635\u0627\u0642\u0627\u062a \u0628\u062c\u062f\u0631\u0627\u0646 \u0627\u0644\u0639\u0628\u0648\u0629, \u062d\u064a\u062b \u062a\u0634\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 S-PEG400(1%) \u0648 S-IPM (1%) \u0642\u062f \u062a\u0643\u0648\u0646 \u0645\u062d\u0644\u0627\u062a \u0645\u0633\u0627\u0639\u062f\u0629 \u0628\u062f\u064a\u0644\u0629 \u0644\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0643\u0645\u0627 \u064a\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644(2). <\/span>\u062a\u0645\u062a \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 in-vitro <\/em>\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 NGI \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a S-ETOH(10%) \u0648 S-PEG400(1%) \u0648 S-IPM(1%) \u0628\u0639\u062f \u062a\u062d\u0631\u064a\u0631 4 \u062c\u0631\u0639\u0627\u062a \u0641\u064a \u0627\u0644\u0647\u0648\u0627\u0621 , \u0648\u0636\u0628\u0637 \u0645\u0639\u062f\u0644 \u062a\u062f\u0641\u0642 \u0627\u0644\u0647\u0648\u0627\u0621 \u0644\u062c\u0647\u0627\u0632 NGI \u0639\u0644\u0649 30 \u0644\u062a\u0631\/ \u062f\u0642\u064a\u0642\u0629 \u0648\u062a\u062d\u0631\u064a\u0631 10 \u062c\u0631\u0639\u0627\u062a \u0636\u0645\u0646 \u062c\u0647\u0627\u0632NGI , \u0648\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062c\u0647\u0627\u0632 \u0648 \u0627\u0644\u0642\u0637\u0639\u0629 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 HPLC \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 (276nm) , \u0648\u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0639\u0628\u0648\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 (\u0639\u062f\u062f \u0627\u0644\u0639\u0628\u0648\u0627\u062a = 5) , \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u064a \u062d\u0635\u0644\u0646\u0627 \u0639\u0644\u064a\u0647\u0627 \u0645\u0648\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644(1).<\/span><\/p>\n

          \"\u0627\u0644\u0634\u0643\u0644(2):
          \u0627\u0644\u0634\u0643\u0644(2): \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0639\u064a\u0627\u0646\u064a \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u062a\u0632\u0627\u064a\u062f\u0629 \u0645\u0646 PEG400 \u0648 IPM \u0648 \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f<\/span><\/figcaption><\/figure>\n
          \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
          \n

          \u0627\u0644\u062c\u062f\u0648\u0644 (1): \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635<\/strong>APSD<\/strong>\u0644\u0643\u0644 \u0645\u0646<\/strong>S-ETOH (10%)<\/strong>\u0648<\/strong>S-PEG400(1%)<\/strong>\u0648<\/strong>S-IPM(1%)<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          NGI Stages<\/span><\/p>\n<\/td>\n

          		\n

          S-ETOH(10%) \u00b1 SD<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400(1%) \u00b1 SD<\/span><\/p>\n<\/td>\n

          		\n

          (S-IPM 1%) \u00b1 SD<\/span><\/p>\n<\/td>\n<\/tr>\n

          induction port (throat)<\/span><\/td>\n33.34 \u00b1 2<\/span><\/td>\n37.97 \u00b1 2.36<\/span><\/td>\n46.67 \u00b1 1.35<\/span><\/td>\n<\/tr>\n
          Actuator<\/span><\/td>\n7.88 \u00b1 1.2<\/span><\/td>\n12.53 \u00b1 1.75<\/span><\/td>\n17.20 \u00b1 1.44<\/span><\/td>\n<\/tr>\n
          stage-1(11.76\u00b5)<\/span><\/td>\nNOT DETECTED<\/span><\/td>\nNOT DETECTED<\/span><\/td>\n4.94 \u00b1 0.73<\/span><\/td>\n<\/tr>\n
          stage-2(6.4\u00b5)<\/span><\/td>\nNOT DETECTED<\/span><\/td>\nNOT DETECTED<\/span><\/td>\n11.53 \u00b1 0.96<\/span><\/td>\n<\/tr>\n
          stage-3(3.99\u00b5)<\/span><\/td>\n7.71 \u00b1 1.64<\/span><\/td>\n14.56 \u00b1 1.48<\/span><\/td>\n14.91 \u00b1 0.18<\/span><\/td>\n<\/tr>\n
          stage-4 (2.3\u00b5)<\/span><\/td>\n26.77 \u00b1 1.36<\/span><\/td>\n26.06 \u00b1 1.45<\/span><\/td>\n12.56 \u00b1 0.7<\/span><\/td>\n<\/tr>\n
          stage-5(1.36\u00b5)<\/span><\/td>\n26.30 \u00b1 3.6<\/span><\/td>\n22.93 \u00b1 1.50<\/span><\/td>\n3.22 \u00b1 0.51<\/span><\/td>\n<\/tr>\n
          stage-6 (0.83\u00b5)<\/span><\/td>\n11.70 \u00b1 1.25<\/span><\/td>\n5.31 \u00b1 1.04<\/span><\/td>\n2.26 \u00b1 0.64<\/span><\/td>\n<\/tr>\n
          stage-7 (0.54\u00b5)<\/span><\/td>\nNOT DETECTED<\/span><\/td>\nNOT DETECTED<\/span><\/td>\n2.39 \u00b1 0.04<\/span><\/td>\n<\/tr>\n
          stage8(MOC)(0.36\u00b5)<\/span><\/td>\nNOT DETECTED<\/span><\/td>\nNOT DETECTED<\/span><\/td>\n3.63 \u00b1 0.49<\/span><\/td>\n<\/tr>\n
          FPM<\/span><\/td>\n72.50 \u00b1 3.08<\/span><\/td>\n68.86 \u00b1 2.49<\/span><\/td>\n32.97 \u00b1 1.46<\/span><\/td>\n<\/tr>\n
          FPF<\/span><\/td>\n63.75 \u00b1 1.72<\/span><\/td>\n57.7 \u00b1 1.72<\/span><\/td>\n27.61 \u00b1 1.62<\/span><\/td>\n<\/tr>\n
          MMAD<\/span><\/td>\n2.23 \u00b1 0.06<\/span><\/td>\n2.6 \u00b1 0.09<\/span><\/td>\n4.46 \u00b1 0.08<\/span><\/td>\n<\/tr>\n
          GSD<\/span><\/td>\n1.64 \u00b1 0.07<\/span><\/td>\n1.70 \u00b1 0.025<\/span><\/td>\n1.96 \u00b1 0.01<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

          \u0645\u0646 \u0627\u0644\u0648\u0627\u0636\u062d \u0641\u064a \u0627\u0644\u0634\u0643\u0644 (3) \u0623\u0646 \u0643\u0645\u064a\u0629 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0640 S-IPM(1%) \u0627\u0644\u0645\u062a\u0648\u0636\u0639\u0629 \u0636\u0645\u0646 \u0627\u0644\u0642\u0637\u0639\u0629 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0644\u0644\u0640MDI \u00a0\u0648throat \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u062c\u0647\u0627\u0632 NGI \u0623\u0643\u0628\u0631 \u0645\u0646 \u0627\u0644\u0643\u0645\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0640 S-PEG400(1%) \u0648 S-ETOH(10%) , \u0643\u0645\u0627 \u0625\u0646 \u0646\u0633\u0628\u0629 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0640 S-IPM(1%) \u0648\u0627\u0644\u0645\u062a\u0648\u0636\u0639\u0629 \u0636\u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0646 \u062c\u0647\u0627\u0632 NGI \u062a\u0639\u0627\u062f\u0644 (15%) \u0645\u0646 \u0625\u062c\u0645\u0627\u0644\u064a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629, \u0628\u064a\u0646\u0645\u0627 \u0644\u0627 \u062a\u0639\u0644\u0642 \u0639\u0644\u0649 \u0627\u0644\u0625\u0637\u0644\u0627\u0642 \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0643\u0644 \u0645\u0646 S-PEG400(1%) \u0648 S-ETOH(10%) \u0636\u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648 \u0627\u0644\u062b\u0627\u0646\u064a\u0629, \u0648\u0647\u0630\u0627 \u062f\u0644\u064a\u0644 \u0639\u0644\u0649 \u0623\u0646 S-IPM(1%) \u062a\u0645\u0644\u0643 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0623\u0643\u0628\u0631 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 S-PEG400(1%) \u0648 S-ETOH(10%). <\/span>\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c C.I.T.D.A.S \u0627\u0644\u062e\u0627\u0635 \u0628\u062c\u0647\u0627\u0632 NGI \u0641\u064a \u062d\u0633\u0627\u0628 \u0627\u0644\u0645\u0639\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0641\u062d\u0635 APSD , \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u064a \u062d\u0635\u0644\u0646\u0627 \u0639\u0644\u064a\u0647\u0627 \u0645\u0648\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u0634\u0643\u0644(4) , \u062d\u064a\u062b \u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 S-IPM(1%) \u064a\u0645\u0644\u0643 \u0623\u0642\u0644 \u0642\u064a\u0645\u0629 \u0644\u0640 FPF \u0648 FPM \u0648 \u0623\u0639\u0644\u0649 \u0642\u064a\u0645\u0629 \u0644\u0640 MMAD , \u062d\u064a\u062b \u0623\u0646 \u0642\u064a\u0645\u0629 FPF \u0644\u0640 S-IPM(1%) \u062a\u0633\u0627\u0648\u064a (27.61 \u00b1 1.62 %)\u00a0 \u0623\u064a \u0623\u0646\u00a0\u00a0\u00a0 S-IPM(1%) \u0647\u064a \u0627\u0644\u0623\u0642\u0644 \u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0625\u062d\u062f\u0627\u062b \u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0627\u0626\u064a \u0643\u0648\u0646 \u0623\u0642\u0644 \u0645\u0646 35% \u0645\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0631\u0626\u0629, \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0623\u0646 S-IPM(1%) \u062a\u0645\u0644\u0643(4.46 \u00b1 0.08\u00b5) MMAD= \u0648\u0647\u064a \u0642\u0631\u064a\u0628\u0629 \u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u0639\u0644\u064a\u0627 \u0644\u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0625\u062d\u062f\u0627\u062b \u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0627\u0626\u064a (1-5\u00b5) , \u0628\u064a\u0646\u0645\u0627 S-PEG400(1%) \u062a\u0645\u0644\u0643 FPF \u0623\u0643\u0628\u0631 \u0645\u0646 35% , \u0648\u062a\u0645\u0644\u0643 MMAD=(2.6 \u00b1 0.09\u00b5) \u0648 \u062a\u062d\u0642\u0642 \u0627\u0644\u0645\u062a\u0637\u0644\u0628\u0627\u062a \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629BP2013 .<\/span><\/p>\n

          \"\u0627\u0644\u0634\u0643\u0644(3):
          \u0627\u0644\u0634\u0643\u0644(3): \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 S-ETOH(10%) \u0648 S-PEG400(1%) \u0648S-IPM(1%) \u0636\u0645\u0646 \u0645\u0631\u0627\u062d\u0644 \u062c\u0647\u0627\u0632 NGI<\/span><\/strong><\/figcaption><\/figure>\n
          \"\u0627\u0644\u0634\u0643\u0644(4):
          \u0627\u0644\u0634\u0643\u0644(4): \u0645\u0639\u0627\u0645\u0644\u0627\u062a \u0641\u062d\u0635 APSD \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0640 S-ETOH(10%) \u0648 S-PEG400(1%) \u0648S-IPM(1%)<\/span><\/strong><\/span><\/figcaption><\/figure>\n

          \u062a\u0645 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 t-student , \u062d\u064a\u062b \u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0625\u0644\u0649 \u0623\u0646 \u0644\u0646\u0648\u0639 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u062a\u0623\u062b\u064a\u0631\u0627\u064b \u0647\u0627\u0645\u0627\u064b \u0630\u0627 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 FPF \u0648 FPM \u00a0\u0648 MMAD \u0648 GSD (p-value<\/em> < 0.05). <\/span>\u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0641\u0625\u0646 1%))PEG400 \u0647\u0648 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0627\u0644\u0623\u0645\u062b\u0644 \u0627\u0644\u0630\u064a \u0633\u064a\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0641\u064a \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0627\u0644\u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0648\u0641\u0642 \u0627\u0644\u062c\u062f\u0648\u0644 (2).<\/span><\/p>\n

          \n\n\n\n\n\n\n\n
          \n

          \u0627\u0644\u062c\u062f\u0648\u0644 (<\/strong>2<\/strong>): \u064a\u0648\u0636\u062d \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649<\/strong>(1%)<\/strong>PEG400 <\/strong><\/span>\u0648\u0646\u0648\u0639 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0639\u0644\u0642 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645
          \n<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          Percentage (%)<\/span><\/p>\n<\/td>\n

          		\n

          Stabilizer Type<\/span><\/p>\n<\/td>\n

          		\n

          Formulation<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          None<\/span><\/p>\n<\/td>\n

          		\n

          None<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          0.01<\/span><\/p>\n<\/td>\n

          		\n

          Oleic Acid<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400-OA<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          0.0001<\/span><\/p>\n<\/td>\n

          		\n

          PVP-k30<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400-PVP<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

          \u062a\u0645\u062a \u062a\u0639\u0628\u0626\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0648\u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0627\u0644\u0628\u062f\u064a\u0644 \u0648\u0641\u0642 \u0627\u0644\u062c\u062f\u0648\u0644(2), \u0643\u0645\u0627 \u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u062b\u0628\u0627\u062a \u0645\u0633\u0631\u0639 \u0641\u064a (40\u00b0C\/75%RH) \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0645\u0646 \u0646\u0627\u062d\u064a\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 NGI \u0641\u064a \u0627\u0644\u0646\u0642\u0627\u0637 (0-3-6) \u0623\u0634\u0647\u0631 , \u0648\u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f S-ETOH \u0645\u0646 \u062e\u0644\u0627\u0644 \u0625\u062c\u0631\u0627\u0621 \u0639\u0645\u0644\u064a\u0629 \u062a\u062d\u0636\u064a\u0631 \u0644\u0644\u0639\u0628\u0648\u0629 , \u0648\u0627\u0642\u062a\u0637\u0627\u0639 \u0627\u0644\u0639\u064a\u0646\u0629 \u0627\u0644\u0645\u0624\u0644\u0641\u0629 \u0645\u0646 \u0639\u0634\u0631 \u062c\u0631\u0639\u0627\u062a , \u0648\u062a\u062d\u062f\u064a\u062f \u0645\u062d\u062a\u0648\u0627\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 HPLC(\u0639\u062f\u062f \u0627\u0644\u0639\u0628\u0648\u0627\u062a=5) , \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u064a \u062d\u0635\u0644\u0646\u0627 \u0639\u0644\u064a\u0647\u0627 \u0645\u0648\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (3).<\/span><\/p>\n

          \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
          \n

          \u0627\u0644\u062c\u062f\u0648\u0644(<\/strong>3<\/strong>): \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u0631\u0639 \u0645\u0646 \u0646\u0627\u062d\u064a\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629.<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

          Formulation<\/span><\/p>\n

          Type<\/span><\/td>\n

          		\n

          Accelerated point(month)<\/span><\/p>\n<\/td>\n

          		\n

          FPM \u00b1 SD<\/span><\/p>\n

          (Micro gram)<\/span><\/p>\n<\/td>\n

          		\n

          FPF \u00b1 SD<\/span><\/p>\n

          (%)<\/span><\/p>\n<\/td>\n

          		\n

          MMAD \u00b1 SD<\/span><\/p>\n

          (micron)<\/span><\/p>\n<\/td>\n

          		\n

          GSD \u00b1 SD<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-ETOH<\/span><\/td>\n\n

          0<\/span><\/p>\n<\/td>\n

          		\n

          72.50 \u00b1 3.08<\/span><\/p>\n<\/td>\n

          		\n

          63.75 \u00b1 1.72<\/span><\/p>\n<\/td>\n

          		\n

          2.23 \u00b1 0.06<\/span><\/p>\n<\/td>\n

          		\n

          1.64 \u00b1 0.07<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400<\/span><\/td>\n\n

          0<\/span><\/p>\n<\/td>\n

          		\n

          56.15 \u00b12.22<\/span><\/p>\n<\/td>\n

          		\n

          56.02 \u00b1 0.65<\/span><\/p>\n<\/td>\n

          		\n

          2.77 \u00b1 0.02<\/span><\/p>\n<\/td>\n

          		\n

          1.67 \u00b1 0.05<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400-OA<\/span><\/td>\n\n

          0<\/span><\/p>\n<\/td>\n

          		\n

          68.86 \u00b1 2.49<\/span><\/p>\n<\/td>\n

          		\n

          57.7 \u00b1 1.72<\/span><\/p>\n<\/td>\n

          		\n

          2.6 \u00b1 0.09<\/span><\/p>\n<\/td>\n

          		\n

          1.70 \u00b1 0.025<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400-PVP<\/span><\/td>\n\n

          0<\/span><\/p>\n<\/td>\n

          		\n

          64.44 \u00b1 4.58<\/span><\/p>\n<\/td>\n

          		\n

          61.12 \u00b1 1.44<\/span><\/p>\n<\/td>\n

          		\n

          2.62 \u00b1 0.023<\/span><\/p>\n<\/td>\n

          		\n

          1.56 \u00b1 0.044<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-ETOH<\/span><\/td>\n\n

          3<\/span><\/p>\n<\/td>\n

          		\n

          58.81 \u00b1 2.20<\/span><\/p>\n<\/td>\n

          		\n

          59.13 \u00b1 0.6<\/span><\/p>\n<\/td>\n

          		\n

          2.62 \u00b1 0.03<\/span><\/p>\n<\/td>\n

          		\n

          1.6 \u00b1 0.03<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400<\/span><\/td>\n\n

          3<\/span><\/p>\n<\/td>\n

          		\n

          40.39 \u00b1 1.22<\/span><\/p>\n<\/td>\n

          		\n

          46.13 \u00b1 0.54<\/span><\/p>\n<\/td>\n

          		\n

          3.33 \u00b1 0.13<\/span><\/p>\n<\/td>\n

          		\n

          1.67 \u00b1 0.02<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400-OA<\/span><\/td>\n\n

          3<\/span><\/p>\n<\/td>\n

          		\n

          53.01 \u00b1 4.14<\/span><\/p>\n<\/td>\n

          		\n

          52.45 \u00b1 1.81<\/span><\/p>\n<\/td>\n

          		\n

          3 \u00b1 0.1<\/span><\/p>\n<\/td>\n

          		\n

          1.76 \u00b1 0.07<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400-PVP<\/span><\/td>\n\n

          3<\/span><\/p>\n<\/td>\n

          		\n

          58.23 \u00b1 2.4<\/span><\/p>\n<\/td>\n

          		\n

          56.28 \u00b1 0.79<\/span><\/p>\n<\/td>\n

          		\n

          2.68 \u00b1 0.01<\/span><\/p>\n<\/td>\n

          		\n

          1.56 \u00b1 0.04<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-ETOH<\/span><\/td>\n\n

          6<\/span><\/p>\n<\/td>\n

          		\n

          51.9 \u00b1 2.4<\/span><\/p>\n<\/td>\n

          		\n

          52.29 \u00b1 1.02<\/span><\/p>\n<\/td>\n

          		\n

          2.75 \u00b1 0.02<\/span><\/p>\n<\/td>\n

          		\n

          1.85 \u00b1 0.08<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400<\/span><\/td>\n\n

          6<\/span><\/p>\n<\/td>\n

          		\n

          7.68 \u00b1 2.68<\/span><\/p>\n<\/td>\n

          		\n

          28.25 \u00b1 4.26<\/span><\/p>\n<\/td>\n

          		\n

          6.11 \u00b1 0.95<\/span><\/p>\n<\/td>\n

          		\n

          2.98 \u00b1 0.5<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400-OA<\/span><\/td>\n\n

          6<\/span><\/p>\n<\/td>\n

          		\n

          3.38 \u00b1 0.96<\/span><\/p>\n<\/td>\n

          		\n

          25.71 \u00b1 4.8<\/span><\/p>\n<\/td>\n

          		\n

          6.45 \u00b1 0.89<\/span><\/p>\n<\/td>\n

          		\n

          3.01 \u00b1 0.43<\/span><\/p>\n<\/td>\n<\/tr>\n

          S-PEG400-PVP<\/span><\/td>\n\n

          6<\/span><\/p>\n<\/td>\n

          		\n

          53.96 \u00b1 1.62<\/span><\/p>\n<\/td>\n

          		\n

          51.84 \u00b1 0.64<\/span><\/p>\n<\/td>\n

          		\n

          2.85 \u00b1 0.02<\/span><\/p>\n<\/td>\n

          		\n

          1.59 \u00b1 0.03<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

          \u062a\u0634\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0648\u0627\u0631\u062f\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 \u0627\u0644\u0633\u0627\u0628\u0642 \u0625\u0644\u0649 \u0623\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629S-PEG400 \u0648 S-PEG400-OA \u0648S-PEG400-PVP \u062a\u0645\u0643\u0646\u062a \u0645\u0646 \u0627\u062c\u062a\u064a\u0627\u0632 \u0646\u0642\u0637\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u0649(\u0627\u0644\u0646\u0642\u0637\u0629 \u0635\u0641\u0631) \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629(\u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631) \u062d\u064a\u062b \u0623\u0646 \u0642\u064a\u0645\u0629 FPF \u0644\u0643\u0644 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u0646\u0642\u0637\u062a\u064a\u0646 \u0623\u0643\u0628\u0631 \u0645\u0646 35% , \u0643\u0645\u0627 \u0623\u0646 \u0642\u064a\u0645\u0629 MMAD \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u0646\u0642\u0637\u062a\u064a\u0646 \u062a\u0642\u0639 \u0636\u0645\u0646 \u0627\u0644\u0645\u062c\u0627\u0644 (1-5\u00b5) , \u0623\u064a \u0623\u0646 \u0643\u0644 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u062c\u062a\u064a\u0627\u0632 \u0627\u0644\u0645\u062a\u0637\u0644\u0628\u0627\u062a \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629 \u0641\u064a \u0646\u0642\u0637\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u0649\u00a0\u00a0 \u0648 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0628\u064a\u0646\u0645\u0627 \u062a\u0634\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0623\u0646 S-PEG400 \u0648 S-PEG400-OA \u0644\u0645 \u062a\u062a\u0645\u0643\u0646 \u0645\u0646 \u0627\u062c\u062a\u064a\u0627\u0632 \u0646\u0642\u0637\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u062b\u0627\u0644\u062b\u0629\u00a0\u00a0\u00a0 (\u0633\u062a\u0629 \u0623\u0634\u0647\u0631), \u062d\u064a\u062b \u0623\u0646 \u0642\u064a\u0645\u0629 FPF \u0644\u0640 S-PEG400 \u062a\u0633\u0627\u0648\u064a (28.25\u00b14.26%) \u0648 \u0644\u0640 S-PEG400-OA \u062a\u0633\u0627\u0648\u064a\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (25.71 \u00b1 4.8%), \u062d\u064a\u062b \u062a\u0634\u064a\u0631 \u0642\u064a\u0645 FPF \u0625\u0644\u0649 \u0623\u0646 \u0643\u0644\u0627\u064b \u0645\u0646 S-PEG400 \u0648S-PEG400-OA \u063a\u064a\u0631 \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0625\u062d\u062f\u0627\u062b \u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0627\u0626\u064a \u0643\u0648\u0646 \u0623\u0642\u0644 \u0645\u0646 35% \u0645\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0631\u0626\u0629 (FPF\u02c235%) ,\u0643\u0645\u0627 \u062a\u0638\u0647\u0631 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0628\u0639\u062f \u0645\u0636\u064a \u0633\u062a\u0629 \u0623\u0634\u0647\u0631 \u0623\u0646 S-PEG400 \u062a\u0645\u0644\u0643 \u0642\u064a\u0645\u0629 MMAD \u062a\u0633\u0627\u0648\u064a (6.11\u00b10.95\u00b5) \u0643\u0645\u0627 \u0623\u0646 \u0642\u064a\u0645\u0629 MMAD \u0644\u0640 S-PEG400-OA \u0628\u0644\u063a\u062a (6.45\u00b10.89\u00b5) , \u0623\u064a \u0623\u0646 \u0642\u064a\u0645\u0629 MMAD \u0644\u0643\u0644\u064d \u0645\u0646 \u00a0\u00a0\u00a0S-PEG400 \u0648 S-PEG400-OA \u062a\u0642\u0639 \u062e\u0627\u0631\u062c \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0645\u0633\u0645\u0648\u062d \u0628\u0647 \u062f\u0633\u062a\u0648\u0631\u064a\u0627\u064b (1-5\u00b5) \u0645\u0645\u0627 \u064a\u0632\u064a\u062f \u0645\u0646 \u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0627\u0644\u0645\u062a\u0648\u0632\u0639\u0629 \u0636\u0645\u0646 \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u0628\u0644\u0639\u0648\u0645\u064a \u0627\u0644\u0641\u0645\u0648\u064a \u0648 \u064a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0648\u0627\u0635\u0644\u0629 \u0625\u0644\u0649 \u0627\u0644\u0631\u0626\u0629, \u0648\u0647\u0630\u0627 \u0645\u0627 \u062a\u0639\u0643\u0633\u0647 \u0642\u064a\u0645 FPF \u0644\u0643\u0644\u0627 \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646.<\/span><\/p>\n

          \u0628\u064a\u0646\u0645\u0627 \u062a\u0634\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0623\u0646 S-PEG400-PVP \u062a\u0645\u0643\u0646\u062a \u0645\u0646 \u0627\u062c\u062a\u064a\u0627\u0632 \u0646\u0642\u0627\u0637 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062b \u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u0631\u0639\u00a0 (40\u00b0C\/75%RH) \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c \u0645\u0646 \u0646\u0627\u062d\u064a\u0629 \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a, \u062d\u064a\u062b \u0623\u0646 \u0642\u064a\u0645\u0629 FPF\u00a0 \u0644\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0623\u0643\u0628\u0631 \u0645\u0646 35% , \u062d\u064a\u062b \u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629 FPF \u0641\u064a \u0627\u0644\u0646\u0642\u0637\u0629 \u0635\u0641\u0631 (61.12 \u00b1 1.44%) \u0648\u0641\u064a \u0627\u0644\u0646\u0642\u0637\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0628\u0639\u062f \u0645\u0636\u064a \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631\u00a0\u00a0\u00a0 (56.28 \u00b1 0.79%) \u0648\u0641\u064a \u0627\u0644\u0646\u0642\u0637\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0628\u0639\u062f \u0645\u0636\u064a \u0633\u062a\u0629 \u0623\u0634\u0647\u0631(51.84\u00a0 \u00b1 0.64%) , \u0643\u0645\u0627 \u0623\u0646 \u0642\u064a\u0645\u0629MMAD \u00a0\u0644\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u062a\u0642\u0639 \u0636\u0645\u0646 \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0645\u0633\u0648\u062d \u0628\u0647 \u062f\u0633\u062a\u0648\u0631\u064a\u0627\u064b (1-5\u00b5) , \u062d\u064a\u062b \u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629MMAD \u00a0\u0641\u064a \u0627\u0644\u0646\u0642\u0637\u0629 \u0635\u0641\u0631\u00a0 (2.62 \u00b1 0.023\u00b5) , \u0648\u0641\u064a \u0627\u0644\u0646\u0642\u0637\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (2.68 \u00b1 0.01\u00b5) , \u0648\u0641\u064a \u0627\u0644\u0646\u0642\u0637\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (2.85\u00a0 \u00b1 0.02\u00b5) , \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u064a \u062d\u0635\u0644\u0646\u0627 \u0639\u0644\u064a\u0647\u0627 \u0645\u0648\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u0634\u0643\u0644(5).<\/span><\/p>\n

          \u064a\u0639\u0632\u0649 \u0630\u0644\u0643 \u0625\u0644\u0649 \u062f\u0648\u0631 PVP-k30 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629, \u062d\u064a\u062b \u062a\u0642\u0648\u0645 \u062c\u0632\u0626\u064a\u0627\u062a PVP-k30 \u0628\u0627\u0644\u0627\u062f\u0645\u0635\u0627\u0635 \u0628\u0634\u0643\u0644 \u0641\u064a\u0644\u0645 \u062f\u0642\u064a\u0642 \u0639\u0644\u0649 \u0633\u0637\u062d \u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a \u0628\u0634\u0643\u0644 \u0641\u064a\u0644\u0645 \u062f\u0642\u064a\u0642 \u0645\u0645\u0627\u064a\u0633\u0628\u0628\u00a0 \u0625\u0639\u0627\u0642\u0629 \u0641\u0631\u0627\u063a\u064a\u0629 \u062a\u0639\u0645\u0644 \u0639\u0644\u0649 \u0645\u0646\u0639 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0645\u0646 \u0627\u0644\u062a\u0645\u0627\u0633 \u0645\u0639 \u0628\u0639\u0636\u0647\u0627\u00a0 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0645\u0646\u0639 \u062a\u0634\u0643\u0644 \u062a\u062c\u0645\u0639\u0627\u062a \u0643\u0645\u0627 \u0623\u0646 \u0625\u0636\u0627\u0641\u0629 PVP-k30 \u064a\u0632\u064a\u062f \u0645\u0646 \u0644\u0632\u0648\u062c\u0629 \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0645\u0645\u0627 \u064a\u0642\u0644\u0644 \u0645\u0646 \u0645\u0639\u062f\u0644 \u062a\u0631\u0633\u064a\u0628 \u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0648\u0641\u0642 \u0642\u0627\u0646\u0648\u0646Stokes \u00a0\u0645\u0645\u0627 \u064a\u0632\u064a\u062f \u0645\u0646 \u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0639\u0644\u0642.24<\/sup><\/span><\/p>\n

          \u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 t-Student \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646S-PEG400 \u0648 S-PEG400-OA \u0648\u00a0\u00a0\u00a0 \u00a0S-PEG400-PVP \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f S-ETOH \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062f\u0644\u0627\u0644\u0629 (=0.05\u03b1) , \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u064a \u062d\u0635\u0644\u0646\u0627 \u0639\u0644\u064a\u0647\u0627 \u0645\u0648\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644(4).<\/span><\/p>\n

          \"\u0627\u0644\u0634\u0643\u0644(5):
          \u0627\u0644\u0634\u0643\u0644(5): \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f \u0641\u064a \u0627\u0644\u0646\u0642\u0627\u0637 (0-3-6) \u0645\u0646 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u0651\u0631\u0639<\/span><\/figcaption><\/figure>\n
          \n\n\n\n\n\n\n\n\n\n\n
          \n

          \u0627\u0644\u062c\u062f\u0648\u0644(<\/strong>4<\/strong>): \u0646\u062a\u0627\u0626\u062c \u0627\u062e\u062a\u0628\u0627\u0631<\/strong>t-student<\/strong>\u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635<\/strong>APSD<\/strong>\u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0648\u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          Response<\/strong><\/span><\/p>\n<\/td>\n

          		\n

          formulation<\/strong><\/span><\/p>\n<\/td>\n

          		\n

          -formulation<\/strong><\/span><\/p>\n<\/td>\n

          		\n

          Difference<\/strong><\/span><\/p>\n<\/td>\n

          		\n

          Std Error<\/strong><\/span><\/p>\n<\/td>\n

          		\n

          t Ratio<\/strong><\/span><\/p>\n<\/td>\n

          		\n

          Prob>|t|<\/strong><\/span><\/p>\n

          p-value<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          FPF<\/span><\/p>\n<\/td>\n

          		\n

          S-ETOH<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400<\/span><\/p>\n<\/td>\n

          		\n

          15.0487<\/span><\/p>\n<\/td>\n

          		\n

          1.880164<\/span><\/p>\n<\/td>\n

          		\n

          8.00<\/span><\/p>\n<\/td>\n

          		\n

          <.0001<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          S-ETOH<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400-OA<\/span><\/p>\n<\/td>\n

          		\n

          13.2010<\/span><\/p>\n<\/td>\n

          		\n

          1.880164<\/span><\/p>\n<\/td>\n

          		\n

          7.02<\/span><\/p>\n<\/td>\n

          		\n

          <.0001<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          S-ETOH<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400-PVP<\/span><\/p>\n<\/td>\n

          		\n

          2.1054<\/span><\/p>\n<\/td>\n

          		\n

          1.880164<\/span><\/p>\n<\/td>\n

          		\n

          1.12<\/span><\/p>\n<\/td>\n

          		\n

          0.2678<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          MMAD<\/span><\/p>\n<\/td>\n

          		\n

          S-ETOH<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400<\/span><\/p>\n<\/td>\n

          		\n

          -1.54747<\/span><\/p>\n<\/td>\n

          		\n

          0.3135278<\/span><\/p>\n<\/td>\n

          		\n

          -4.94<\/span><\/p>\n<\/td>\n

          		\n

          <.0001<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          S-ETOH<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400-OA<\/span><\/p>\n<\/td>\n

          		\n

          -1.48473<\/span><\/p>\n<\/td>\n

          		\n

          0.3135278<\/span><\/p>\n<\/td>\n

          		\n

          -4.74<\/span><\/p>\n<\/td>\n

          		\n

          <.0001<\/span><\/p>\n<\/td>\n<\/tr>\n

          \n

          S-ETOH<\/span><\/p>\n<\/td>\n

          		\n

          S-PEG400-PVP<\/span><\/p>\n<\/td>\n

          		\n

          -0.18347<\/span><\/p>\n<\/td>\n

          		\n

          0.3135278<\/span><\/p>\n<\/td>\n

          		\n

          -0.59<\/span><\/p>\n<\/td>\n

          		\n

          0.5609<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

          \u062a\u0634\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u062a\u0623\u062b\u064a\u0631 \u0647\u0627\u0645 \u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0639\u0646\u062f \u0645\u0642\u0627\u0631\u0646\u0629 \u0642\u064a\u0645 FPF \u0648 MMAD \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0641\u062d\u0635 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 \u0645\u0646 S-PEG400 \u0648S-PEG400-OA \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f S-ETOH \u062d\u064a\u062b \u0623\u0646 \u0642\u064a\u0645\u0629 (p-value\u02c20.05), \u0628\u064a\u0646\u0645\u0627 \u062a\u0634\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062a\u0623\u062b\u064a\u0631 \u0647\u0627\u0645 \u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0639\u0646\u062f \u0645\u0642\u0627\u0631\u0646\u0629 FPF \u0648 MMAD \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0640S-PEG400-PVP \u0648\u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062fS-ETOH \u00a0, \u062d\u064a\u062b \u0623\u0646 \u0642\u064a\u0645\u0629 (p-value\u02c30.05). \u064a\u0648\u0636\u062d \u0627\u0644\u0634\u0643\u0644(6) \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f, \u062d\u064a\u062b \u064a\u0644\u0627\u062d\u0638 \u0645\u0646 \u0627\u0644\u0634\u0643\u0644 \u0623\u0646 \u0642\u064a\u0645 FPF \u0648 MMAD \u0644\u0640 S-PEG400-PVP \u062a\u0642\u0639 \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062f\u0646\u064a\u0627 \u0648 \u0627\u0644\u0639\u0644\u064a\u0627 \u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f, \u0628\u064a\u0646\u0645\u0627 \u062a\u0642\u0639 \u0642\u064a\u0645 FPF \u0648 MMAD \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0640\u00a0\u00a0\u00a0\u00a0 S-PEG400 \u0648 S-PEG400-OA \u062e\u0627\u0631\u062c \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062f\u0646\u064a\u0627 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0640 FPF \u0648\u0627\u0644\u0639\u0644\u064a\u0627 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0640MMAD \u0639\u0646\u062f \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f.<\/span><\/p>\n

          \"\u0627\u0644\u0634\u0643\u0644
          \u00a0 \u0627\u0644\u0634\u0643\u0644 (6): \u0631\u0633\u0645 \u062a\u0648\u0636\u064a\u062d\u064a \u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0642\u064a\u0645 FPF \u0648MMAD \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0648 \u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f<\/span><\/strong><\/figcaption><\/figure>\n

          \u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong>:<\/strong><\/span><\/p>\n

          \u0625\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 PEG400(1%) \u0628\u0648\u062c\u0648\u062f PVP-k30(0.0001%)\u0647\u064a \u0635\u064a\u063a\u0629 \u062b\u0627\u0628\u062a\u0629 \u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 , \u0648\u0628\u062f\u064a\u0644 \u062c\u064a\u062f \u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0634\u0627\u0647\u062f \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0628\u0646\u0633\u0628\u0629 (10% ) \u0645\u0646 \u0646\u0627\u062d\u064a\u0629 \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0623\u0628\u0639\u0627\u062f \u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062d\u0631\u0631\u0629 (\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062d). \u064a\u062c\u0628 \u0623\u0646 \u062a\u062a\u0628\u0639 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u062f\u0631\u0627\u0633\u0629 \u0644\u0627\u0633\u062a\u0643\u0645\u0627\u0644 \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0644\u0636\u0645\u0627\u0646 \u062c\u0648\u062f\u0629 \u0639\u0645\u0644 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0627\u0631\u0630\u0627\u0630\u064a \u0627\u0644\u062e\u0627\u0644\u064a \u0645\u0646 \u0627\u0644\u0627\u064a\u062a\u0627\u0646\u0648\u0644 \u0648\u0627\u0644\u062d\u0627\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0633\u0627\u0644\u0628\u0648\u062a\u0627\u0645\u0648\u0644 \u0633\u0644\u0641\u0627\u062a.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

          \u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u064a\u0639\u062f \u0627\u0644\u0633\u0628\u064a\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0623\u062d\u062f \u0623\u0647\u0645 \u0637\u0631\u0642 \u0625\u064a\u062a\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621 \u0646\u0638\u0631\u0627\u064b \u0644\u0645\u0627 \u062a\u062a\u0645\u062a\u0639 \u0628\u0647 \u0627\u0644\u0631\u0626\u0629 \u0645\u0646 \u0645\u0633\u0627\u062d\u0629 \u0643\u0628\u064a\u0631\u0629 \u0645\u0639\u062f\u0629 \u0644\u0644\u0627\u0645\u062a\u0635\u0627\u0635 (100\u06452) ,…
          \u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":382,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-134","volume-9","year-10"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=119"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/119\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/382"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}