{"id":123,"date":"2023-01-01T11:39:56","date_gmt":"2023-01-01T11:39:56","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=123"},"modified":"2024-07-19T14:04:52","modified_gmt":"2024-07-19T14:04:52","slug":"%d8%aa%d8%ad%d8%b6%d9%8a%d8%b1-%d8%a3%d9%81%d9%84%d8%a7%d9%85-%d8%b9%d9%8a%d9%86%d9%8a%d8%a9-%d9%84%d9%84%d8%a8%d8%b1%d9%8a%d9%85%d9%88%d9%86%d9%8a%d8%af%d9%8a%d9%86-%d8%b7%d8%b1%d8%b7%d8%b1%d8%a7","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=123","title":{"rendered":"\u062a\u062d\u0636\u064a\u0631 \u0623\u0641\u0644\u0627\u0645 \u0639\u064a\u0646\u064a\u0629 \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0648\u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c"},"content":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction:<\/span><\/strong><\/p>\n

\u064a\u0639\u062f \u0627\u0644\u0632\u0631\u0642 \u0645\u0646 \u0623\u0634\u064a\u0639 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u062a\u064a \u062a\u0635\u064a\u0628 \u0627\u0644\u0639\u064a\u0646 \u0643\u0645\u0627 \u0623\u0646\u0647\u0627 \u0627\u0644\u0645\u0633\u0628\u0628 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0639\u0645\u0649 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 (1)\u060c \u0625\u0646\u0651 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0641\u064a \u062e\u0641\u0636 \u0627\u0644\u0636\u063a\u0637 \u062f\u0627\u062e\u0644 \u0627\u0644\u0645\u0642\u0644\u0629 \u0644\u0636\u0645\u0627\u0646 \u0639\u062f\u0645 \u062a\u062f\u0647\u0648\u0631 \u0627\u0644\u062d\u0627\u0644\u0629 (2). \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0623\u0634\u0643\u0627\u0644 \u0639\u0642\u064a\u0645\u0629\u060c \u0648\u0631\u0642\u064a\u0642\u0629 \u064a\u062a\u0645\u0651 \u062a\u0635\u0645\u064a\u0645 \u062d\u062c\u0645\u0647\u0627 \u0648\u0634\u0643\u0644\u0647\u0627 \u0628\u062d\u064a\u062b \u064a\u062a\u0646\u0627\u0633\u0628 \u0645\u0639 \u062a\u0637\u0628\u064a\u0642\u0647\u0627 \u0641\u064a \u0643\u064a\u0633 \u0627\u0644\u0645\u0644\u062a\u062d\u0645\u0629 (cul de sac) \u0641\u064a \u0627\u0644\u0639\u064a\u0646. \u062a\u0624\u0645\u0646 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0632\u0627\u064a\u0627 \u0645\u062b\u0644 \u0632\u064a\u0627\u062f\u0629 \u0632\u0645\u0646 \u0627\u0644\u0628\u0642\u0627\u0621 \u0641\u064a \u0627\u0644\u0639\u064a\u0646\u060c \u0648\u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0628\u0637\u0621\u060c \u0648\u062f\u0642\u0629 \u0627\u0644\u062c\u0631\u0639\u0629\u060c \u0648\u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u062c\u0647\u0627\u0632\u064a \u0644\u0644\u062f\u0648\u0627\u0621\u060c \u0648\u0632\u064a\u0627\u062f\u0629 \u0645\u0637\u0627\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0628\u0633\u0628\u0628 \u0627\u0646\u062e\u0641\u0627\u0636 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0625\u0639\u0637\u0627\u0621 \u0648\u0642\u0644\u0629 \u062d\u062f\u0648\u062b \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629 \u0648\u0627\u0644\u062c\u0647\u0627\u0632\u064a\u0629 \u0648\u0632\u064a\u0627\u062f\u0629 \u0639\u0645\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0639\u0644\u0649 \u0627\u0644\u0631\u0641 shelf-life \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0645\u0627\u0626\u064a\u0629\u060c \u0648\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062d\u0627\u0641\u0638\u0629\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0642\u0644\u064a\u0644 \u0645\u062e\u0627\u0637\u0631 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 (3). \u0635\u064f\u0646\u0651\u0641\u062a \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0648\u0641\u0642\u064b\u0627 \u0644\u0642\u0627\u0628\u0644\u064a\u062a\u0647\u0627 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 \u0625\u0644\u0649 \u0623\u0641\u0644\u0627\u0645\u00a0 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 \u0623\u0648 \u063a\u064a\u0631 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 \u0623\u0648 \u062f\u0631\u0648\u0643\u0629 \u062d\u064a\u0648\u064a\u0627\u064b.(4) \u062a\u0645\u0651 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0645\u0644 \u0639\u0644\u0649 \u0635\u064a\u0627\u063a\u0629 \u0623\u0641\u0644\u0627\u0645 \u0639\u064a\u0646\u064a\u0629 \u0645\u0646 \u0645\u0627\u062f\u0629 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0632\u0631\u0642 \u0648\u0647\u064a \u0645\u0627\u062f\u0629 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0648\u062a\u0648\u062c\u062f \u0639\u0644\u0649 \u0634\u0643\u0644 \u0642\u0637\u0631\u0627\u062a \u0639\u064a\u0646\u064a\u0629 (Alphagan Z\u00ae).<\/span><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong> Materials and methods<\/strong><\/span><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629<\/strong><\/span><\/p>\n

\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a(Brimonidine Tartrate) (Medichem SA, Spain)\u060c \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0628\u0631\u0648\u0628\u064a\u0644 \u0645\u064a\u062a\u064a\u0644 \u0633\u064a\u0644\u0644\u0648\u0632 (HPMC K15M) (Shreeji chemical, India)\u060c \u0628\u0648\u0641\u064a\u062f\u0648\u0646 PVP-k30 (Poly Vinyl Pyrrolidine) (Shreeji chemical, India)\u060c \u0628\u0648\u0644\u064a \u0627\u064a\u062a\u064a\u0644\u064a\u0646 \u063a\u0644\u064a\u0643\u0648\u0644 PEG 400 (Poly ethylene glycol) (Sigma-Aldrich, Germany).<\/span><\/p>\n

\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a <\/strong>Brimonidine Tartrate<\/strong><\/span><\/p>\n

\u064a\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 1 \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0648\u0647\u0648 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate . \u064a\u062a\u0648\u0627\u062c\u062f \u0639\u0644\u0649 \u0634\u0643\u0644 \u0645\u0633\u062d\u0648\u0642 \u0630\u064a \u0644\u0648\u0646 \u0623\u0628\u064a\u0636 \u0623\u0648 \u0623\u0635\u0641\u0631 \u0634\u0627\u062d\u0628\u060c \u0639\u062f\u064a\u0645 \u0627\u0644\u0631\u0627\u0626\u062d\u0629\u060c \u0630\u0648\u0627\u0628 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0648\u0627\u0644\u0645\u064a\u062a\u0627\u0646\u0648\u0644 (5).<\/span><\/p>\n

\"\u0627\u0644\u0634\u0643\u0644
\u0627\u0644\u0634\u0643\u0644 1: \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a<\/strong><\/figcaption><\/figure>\n

\u0627\u0633\u0640\u062a\u062e\u062f\u0645 \u0641\u0640\u064a \u0627\u0644\u0628\u062d\u0640\u062b \u0627\u0644\u0623\u062c\u0647\u0632\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0640\u0629<\/strong>:<\/strong><\/span><\/p>\n

\u062e\u0644\u064a\u0629 \u0641\u0631\u0646\u0632 \u0645\u062d\u0644\u064a\u0629 \u0627\u0644\u0635\u0646\u0639 Franz cell\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0637\u064a\u0641\u064a \u0641\u064a \u0645\u062c\u0627\u0644 \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0645\u0631\u0626\u064a\u0629 \u0648\u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 (PG Instruments T80+, UK)\u060c \u062c\u0647\u0627\u0632 \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621FTIR\u060c Germany) ,(Bruker IR-10049361\u060c \u0641\u0631\u0646 \u062a\u062c\u0641\u064a\u0641 (Carbolite PF30, Germany)\u060c \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u062f\u0631\u062c\u0629 \u0628\u0627\u0647\u0627\u0621 \u0627\u0644\u0648\u0633\u0637 , Romania) (Hanna Instruments pH 211 Microprocessor pH Meter\u060c<\/a> \u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 (Digital ultrasonic cleaner, Italy)\u060c \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u0627\u0644\u062b\u062e\u0627\u0646\u0629 (Digital caliper DigiMax, Germany).<\/span><\/p>\n

\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0628\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a<\/strong><\/span><\/p>\n

\u0623\u064f\u062c\u0631\u064a \u0645\u0633\u062d \u0637\u064a\u0641\u064a \u0639\u0644\u0649 \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0636\u0645\u0646 \u0645\u062c\u0627\u0644 \u0627\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 \u0644\u062a\u062d\u062f\u064a\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a\u060c \u0645\u0639 \u062a\u0643\u0631\u0627\u0631 \u0643\u0644 \u0642\u064a\u0627\u0633 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a (n=3). \u0648\u062a\u0645\u0651 \u0627\u0639\u062a\u0645\u0627\u062f \u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a \u0630\u0648 pH 7.4 \u0643\u0648\u0633\u0637 \u0627\u0646\u062d\u0644\u0627\u0644 \u0645\u0646\u0627\u0633\u0628 \u0648\u0641\u0642\u0627\u064b \u0644\u0640Sajeev \u00a0\u0648\u0632\u0645\u0644\u0627\u0624\u0647 (6). \u0648\u062a\u0645 \u062a\u062d\u0636\u064a\u0631 \u0633\u0644\u0633\u0644\u0629 \u0639\u064a\u0627\u0631\u064a\u0629 \u062a\u0631\u0627\u0648\u062d\u062a \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0628\u064a\u0646 (2-18 \u0645\u0643\u063a\/\u0645\u0644)\u060c \u0648\u0630\u0644\u0643 \u0627\u0646\u0637\u0644\u0627\u0642\u0627\u064b \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0623\u0645 stock solution 20 \u0645\u0643\u063a\/\u0645\u0644.<\/span><\/p>\n

\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 <\/strong><\/span><\/p>\n

\u0627\u0633\u062a\u064f\u062e\u062f\u0645 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0628\u0631\u0648\u0628\u064a\u0644 \u0645\u064a\u062a\u064a\u0644 \u0633\u064a\u0644\u0644\u0648\u0632 HPMC K15M\u060c \u0628\u0648\u0644\u064a \u0641\u064a\u0646\u064a\u0644 \u0628\u064a\u0631\u0648\u0644\u064a\u062f\u064a\u0646 pvp-k30 \u0643\u0639\u0648\u0627\u0645\u0644 \u0645\u0634\u0643\u0651\u0644\u0629 \u0644\u0645\u0637\u0631\u0633 \u0627\u0644\u0641\u0644\u0645 \u0648\u062a\u0645\u0651\u062a \u0625\u0636\u0627\u0641\u0629 PEG400 \u0643\u0639\u0627\u0645\u0644 \u0645\u0644\u062f\u0651\u0646 \u0644\u0644\u0641\u0644\u0645. <\/span>\u062a\u0645 \u062a\u062d\u0636\u064a\u0631 \u0639\u062f\u0629 \u0635\u064a\u063a \u062a\u062a\u0636\u0645\u0646 \u0646\u0633\u0628\u0627\u064b \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 HPMC k15m \u0648 PVP-k30\u060c \u0645\u0639 \u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629 \u0648\u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0645\u0646\u0647\u0627 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c. <\/span>\u0648\u064a\u062a\u0623\u062b\u0631 \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0645\u0637\u0627\u0631\u0633 \u0627\u0644\u0628\u0645\u0644\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0648\u064a HPMC \u0628\u0639\u062f\u0629 \u0639\u0648\u0627\u0645\u0644 \u0645\u062b\u0644 \u0643\u0645\u064a\u0629 \u0627\u0644\u0628\u0644\u0645\u0631 \u0648\u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u062f\u0627\u0648\u0621 \u0648\u0646\u0633\u0628(\u0628\u0644\u0645\u0631: \u062f\u0648\u0627\u0621)\u060c \u0648\u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u062c\u0632\u0626\u064a \u0644\u0644\u0628\u0644\u0645\u0631 \u0648\u0627\u0644\u0644\u0632\u0648\u062c\u0629 \u0648\u062e\u0648\u0627\u0635 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0646\u0648\u0639 \u0627\u0644\u0642\u0627\u0644\u0628 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645. \u062d\u064a\u062b \u0625\u0646\u0647 \u0639\u0646\u062f \u062a\u0645\u0627\u0633 \u0627\u0644\u0628\u0644\u0645\u0631 \u0645\u0639 \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u060c \u064a\u0646\u0641\u0630 \u0627\u0644\u0648\u0633\u0637 \u0639\u0628\u0631 \u0645\u0633\u0627\u0645\u0627\u062a \u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0648\u064a\u062a\u0634\u0643\u0644 \u0647\u0644\u0627\u0645 \u0628\u0633\u0628\u0628 \u0625\u0645\u0627\u0647\u0629 \u0633\u0644\u0627\u0633\u0644 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u062a\u0623\u062b\u0651\u0631 \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621.(7) \u0623\u0645\u0627 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0644\u062f\u0651\u0646 PEG 400 \u0641\u0642\u062f \u0623\u064f\u0636\u064a\u0641 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0651\u0631\u0629 \u0628\u0646\u0633\u0628\u0629 20% (\u0648\/\u0648) \u0645\u0646 \u0648\u0632\u0646 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u062c\u0627\u0641\u0629\u060c \u062d\u064a\u062b \u0623\u0646 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0646 20% \u0623\u0639\u0637\u062a \u0644\u062f\u0648\u0646\u0629 \u0634\u062f\u064a\u062f\u0629 \u0645\u0645\u0627 \u062c\u0639\u0644 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u063a\u064a\u0631 \u0645\u0642\u0628\u0648\u0644\u0629\u060c \u0628\u064a\u0646\u0645\u0627 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0623\u0642\u0644 \u0645\u0646 20% \u0623\u0639\u0637\u062a \u0623\u0641\u0644\u0627\u0645 \u0642\u0627\u0633\u064a\u0629 \u0645\u0645\u0627 \u062c\u0639\u0644 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0633\u0647\u0644\u0629 \u0627\u0644\u0643\u0633\u0631 \u0648\u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0637\u064a \u0644\u0647\u0627 \u063a\u064a\u0631 \u0645\u0642\u0628\u0648\u0644\u0629. (8). \u062a\u0645\u0651 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0637\u0631\u0633 \u0627\u0644\u0641\u0644\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 \u0635\u0628 \u0627\u0644\u0645\u062d\u0644 (Solvent Casting). \u0623\u0636\u064a\u0641\u062a \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 \u062a\u062f\u0631\u064a\u062c\u064a\u0627\u064b\u060c \u0648\u0645\u0646 \u062b\u0645 \u0627\u0644\u0645\u0644\u062f\u0646 \u0648\u0630\u0644\u0643 \u0641\u064a 10 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u062d\u0644 \u0641\u064a \u0628\u064a\u0634\u0631 \u0645\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u062d\u0631\u064a\u0643 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0644\u0645\u062f\u0629 3 \u0633\u0627\u0639\u0627\u062a\u060c \u0648\u0645\u0646 \u062b\u0645 \u0648\u064f\u0636\u0639\u062a \u0641\u064a \u062d\u0645\u0627\u0645 \u0645\u0627\u0626\u064a \u0645\u0639 Ultrasound \u0644\u0645\u062f\u0629 30 \u062f\u0642\u064a\u0642\u0629 \u0644\u0636\u0645\u0627\u0646 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644 \u0648\u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u062d\u0644\u0648\u0644 \u0631\u0627\u0626\u0642 \u062e\u0627\u0644\u064d \u0645\u0646 \u0641\u0642\u0627\u0639\u0627\u062a \u0627\u0644\u0647\u0648\u0627\u0621. \u062a\u0645\u0651 \u0635\u0628 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0645\u0637\u0631\u0633 \u0641\u064a \u0637\u0628\u0642 \u0628\u062a\u0631\u064a \u0628\u0644\u0627\u0633\u062a\u064a\u0643\u064a \u0645\u0633\u0627\u062d\u062a\u0647 (19.65) \u0633\u06452 \u0648\u0648\u064f\u0636\u0650\u0639 \u0642\u0645\u0639 \u0645\u0642\u0644\u0648\u0628 \u0641\u0648\u0642\u0647\u0627 \u0645\u0639 \u0633\u062f \u0641\u062a\u062d\u0629 \u0627\u0644\u0642\u0645\u0639 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0642\u0637\u0646 \u0644\u0636\u0645\u0627\u0646 \u0639\u062f\u0645 \u0627\u0644\u062a\u0628\u062e\u0631 \u0627\u0644\u0633\u0631\u064a\u0639 \u0644\u0644\u0645\u062d\u0644\u060c \u062b\u0645 \u0648\u064f\u0636\u0639\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0641\u064a \u0641\u0631\u0646 \u0627\u0644\u062a\u062c\u0641\u064a\u0641 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u00b037\u0645 \u0644\u0645\u062f\u0629 48 \u0633\u0627\u0639\u0629.<\/span><\/p>\n

\"\"<\/p>\n

\u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0637\u0628\u0642\u0629<\/strong><\/span><\/p>\n

\u0627\u062e\u062a\u0628\u0627\u0631 \u062a\u062c\u0627\u0646\u0633 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 <\/strong>Content uniformity<\/strong> (9)<\/span><\/p>\n

\u062a\u0645\u0651 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0639\u0644\u0649 \u062b\u0644\u0627\u062b\u0629 \u0623\u0641\u0644\u0627\u0645 \u0645\u062a\u0633\u0627\u0648\u064a\u0646 \u0641\u064a \u0627\u0644\u0648\u0632\u0646 \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0645\u062d\u0636\u0631\u0629\u060c \u0648\u0642\u064a\u0627\u0633 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0641\u064a \u0643\u0644 \u0641\u0644\u0645\u060c \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a \u0644\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0636\u0648\u0626\u064a\u060c \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u0639\u0627\u062f\u0644\u0629 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0633\u0628\u0642\u0627\u064b\u060c \u062d\u064a\u062b \u062a\u0645\u0651 \u062d\u0644 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0645\u0646 \u0627\u0644\u0641\u0644\u0645 \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u0629 10 \u0645\u0644\u060c \u0641\u064a 10 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a (pH 7.4) \u062b\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 Ultrasound \u0644\u0645\u062f\u0629 3 \u0633\u0627\u0639\u0627\u062a\u060c \u062a\u0645\u0651 \u062a\u0631\u0634\u064a\u062d \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0631\u0634\u062d\u0629 \u0642\u0628\u0644 \u0627\u0644\u0642\u064a\u0627\u0633((chrompure PTFE syringe filter, 0.45 \u00b5m. <\/span>\u0642\u064a\u0633 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a \u0645\u0642\u0627\u0628\u0644 \u0645\u062d\u0644\u0648\u0644 \u0634\u0627\u0647\u062f blank \u0645\u062d\u0636\u0631 \u0628\u0646\u0641\u0633 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0648\u063a\u064a\u0631 \u0645\u062a\u0636\u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629(\u0633\u0648\u0627\u063a\u0627\u062a \u0641\u0642\u0637).<\/span><\/p>\n

\u0627\u062e\u062a\u0628\u0627\u0631 \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0637\u064a <\/strong>Folding endurance<\/strong> (9)<\/span><\/p>\n

\u062a\u0645\u0651 \u0627\u0644\u0639\u0645\u0644 \u0639\u0644\u0649 3 \u0623\u0641\u0644\u0627\u0645 \u0641\u064a \u0643\u0644 \u0635\u064a\u063a\u0629\u060c \u062d\u064a\u062b \u062a\u0645\u0651 \u0637\u064a \u0627\u0644\u0641\u0644\u0645 \u0645\u0646 \u0645\u0646\u0637\u0642\u0629 \u0645\u062d\u062f\u062f\u0629 \u0639\u062f\u0629 \u0645\u0631\u0627\u062a \u062d\u062a\u0649 \u064a\u062d\u062f\u062b \u062a\u0634\u0642\u0642\u0627\u064b. \u062d\u064f\u062f\u0651\u062f\u062a \u0642\u064a\u0645\u0629 \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0637\u064a \u0628\u0639\u062f\u062f \u0627\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0645\u0651 \u0641\u064a\u0647\u0627 \u0637\u064a \u0627\u0644\u0641\u0644\u0645 \u062f\u0648\u0646 \u0623\u0646 \u064a\u062a\u0634\u0642\u0642.<\/span><\/p>\n

\u0627\u062e\u062a\u0628\u0627\u0631 \u0642\u0628\u0637 \u0627\u0644\u0631\u0637\u0648\u0628\u0629<\/strong> Moisture uptake<\/strong> (10)<\/span><\/p>\n

\u062a\u0645 \u0627\u0644\u062a\u062d\u0642\u0651\u0642 \u0645\u0646 \u0646\u0633\u0628\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0645\u0646 \u0627\u0644\u0623\u0641\u0644\u0627\u0645\u060c \u0644\u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a. \u062a\u0645\u0651 \u0627\u0644\u0639\u0645\u0644 \u0639\u0644\u0649 \u062b\u0644\u0627\u062b\u0629 \u0623\u0641\u0644\u0627\u0645\u060c \u062d\u064a\u062b \u062a\u0645\u0651 \u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0628\u062f\u0626\u064a \u0642\u0628\u0644 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u060c \u062b\u0645 \u0648\u064f\u0636\u0639\u062a \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0641\u064a \u0645\u062c\u0641\u0641 (desiccator)\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u062d\u0648\u064a 100 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0645\u0634\u0628\u0639 \u0644\u0643\u0644\u0648\u0631 \u0627\u0644\u0628\u0648\u062a\u0627\u0633\u064a\u0648\u0645 \u062b\u0645 \u0648\u064f\u0636\u0639 \u0641\u064a \u0641\u0631\u0646 \u0627\u0644\u062a\u062c\u0641\u064a\u0641 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629 \u00ba25\u0645. <\/span>\u0642\u064a\u0633 \u0627\u0644\u0648\u0632\u0646 \u0628\u0639\u062f 3 \u0623\u064a\u0627\u0645 \u0648\u062d\u064f\u0633\u0628\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u0639\u0627\u062f\u0644\u0629:<\/span><\/p>\n

\"\"<\/p>\n

\u0643\u0645\u0627 \u062d\u064f\u0633\u0628 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a SD.<\/span><\/p>\n

\u0627\u062e\u062a\u0628\u0627\u0631 \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0631\u0637\u0648\u0628\u0629<\/strong> moisture loss<\/strong> (10)<\/span><\/p>\n

\u0644\u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0623\u0647\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0641\u064a \u0627\u0644\u0638\u0631\u0648\u0641 \u0627\u0644\u062c\u0627\u0641\u0629\u060c \u062a\u0645 \u0627\u0644\u0639\u0645\u0644 \u0639\u0644\u0649 \u062b\u0644\u0627\u062b\u0629 \u0623\u0641\u0644\u0627\u0645\u060c \u0648\u0623\u062e\u0630 \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0628\u062f\u0626\u064a \u062b\u0645 \u0648\u064f\u0636\u0639\u062a \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0641\u064a \u0645\u062c\u0641\u0641 (desiccator)\u060c \u0645\u0639 \u0648\u062c\u0648\u062f \u0645\u0644\u062d \u0643\u0644\u0648\u0631 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0627\u0644\u0644\u0627\u0645\u0627\u0626\u064a (anhydrous calcium chloride) \u0648\u062a\u0645 \u0648\u0636\u0639 \u0627\u0644\u0645\u062c\u0641\u0641 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629 \u00ba25 \u0645.<\/span><\/p>\n

\u062a\u0645\u0651 \u0623\u062e\u0630 \u0627\u0644\u0648\u0632\u0646 \u0628\u0639\u062f 3 \u0623\u064a\u0627\u0645 \u0648\u062a\u0645\u0651 \u062d\u0633\u0627\u0628 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0641\u0642\u062f \u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u0639\u0627\u062f\u0644\u0629:<\/span><\/p>\n

\u0643\u0645\u0627 \u062a\u0645\u0651 \u062d\u0633\u0627\u0628 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a SD.<\/span><\/p>\n

\u062f\u0631\u062c\u0629 \u0628\u0627\u0647\u0627\u0621 \u0627\u0644\u0633\u0637\u062d<\/strong> \u00a0pH of the surface<\/strong>(11)<\/span><\/p>\n

\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u062e\u062a\u0628\u0627\u0631 pH \u0627\u0644\u0633\u0637\u062d \u0644\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062d\u062f\u0648\u062b \u0623\u064a \u062a\u0647\u064a\u062c \u0645\u062d\u062a\u0645\u0644 \u0644\u0644\u0639\u064a\u0646. \u062a\u064f\u0631\u0650\u0643\u062a \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0628\u0627\u0644\u0627\u0646\u062a\u0628\u0627\u062c \u0641\u064a \u0637\u0628\u0642 \u0628\u062a\u0631\u064a \u0645\u063a\u0644\u0642\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629 \u0644\u0645\u062f\u0629 30 \u062f\u0642\u064a\u0642\u0629\u060c \u0641\u064a 10. \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631. \u062a\u0645 \u0648\u0636\u0639 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0645\u0646\u062a\u0628\u062c\u0629 \u062a\u062d\u062a \u0623\u0642\u0637\u0627\u0628 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0640pH \u0627\u0644\u0631\u0642\u0645\u064a(\u0648\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0623\u064a\u0636\u0627\u064b \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0648\u0631\u0627\u0642 \u0627\u0644\u0640pH) \u0644\u062a\u062d\u062f\u064a\u062f \u062f\u0631\u062c\u0629 \u0628\u0627\u0647\u0627\u0621 \u0627\u0644\u0633\u0637\u062d.<\/span><\/p>\n

\u0645\u0648\u062d\u0648\u062f\u064a\u0629 \u0627\u0644\u062b\u062e\u0627\u0646\u0629<\/strong>thickness uniformity <\/strong>\u00a0(12)<\/span><\/p>\n

\u062d\u064f\u062f\u0651\u062f \u0645\u062a\u0648\u0633\u0637 \u062b\u062e\u0627\u0646\u0629 \u0627\u0644\u0627\u0641\u0644\u0627\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 digiMax\u060c \u0628\u0623\u062e\u0630 \u0642\u064a\u0627\u0633 \u0643\u0644 \u0641\u0644\u0645 3 \u0645\u0631\u0627\u062a \u0648\u062d\u0633\u0627\u0628 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a<\/span><\/p>\n

\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062a\u062d\u0631\u0631 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c<\/strong> In vitro <\/em><\/strong>drug release rate <\/strong>\u00a0(13)<\/strong><\/span><\/p>\n

\u062a\u0645\u0651 \u0627\u062e\u062a\u0628\u0627\u0631 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062e\u0644\u064a\u0629 \u0645\u062d\u0644\u064a\u0629 \u0627\u0644\u0635\u0646\u0639 \u0645\u062d\u0627\u0643\u064a\u0629 \u0644\u0639\u0645\u0644 \u062e\u0644\u064a\u0629 \u0641\u0631\u0627\u0646\u0632 (\u0627\u0644\u0634\u0643\u0644 2)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062a\u0643\u0648\u0646 \u0645\u0646 \u0627\u0644\u0623\u062c\u0632\u0627\u0621 \u0627\u0644\u062a\u0627\u0644\u064a\u0629:<\/span><\/p>\n

\u062d\u062c\u0631\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u0629 \u062d\u062c\u0645 12 \u0645\u0644\u060c \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0645\u062d\u0644\u0648\u0644 \u062f\u0627\u0631\u0626\u0629 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a (pH 7.4) \u0643\u0648\u0633\u0637 \u0630\u0648\u0628\u0627\u0646. <\/span>\u062d\u062c\u0631\u0629 \u0645\u0639\u0637\u064a\u0629 \u064a\u0651\u062b\u0628\u0651\u062a \u0641\u0648\u0642\u0647\u0627 \u0627\u0644\u0641\u0644\u0645 \u0627\u0644\u0639\u064a\u0646\u064a \u0639\u0644\u0649 \u063a\u0634\u0627\u0621 \u0635\u0646\u0639\u064a \u0645\u0646 \u0646\u062a\u0631\u0627\u062a \u0627\u0644\u0633\u064a\u0644\u0644\u0648\u0632 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u0645\u0633\u0627\u0645 0.45 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631. \u062a\u0645\u0651 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0627 \u0627\u0644\u063a\u0634\u0627\u0621 \u0641\u064a \u0645\u062d\u0627\u0648\u0644\u0629 \u0644\u0645\u062d\u0627\u0643\u0627\u0629 \u0638\u0631\u0648\u0641 \u0627\u0644\u0639\u064a\u0646 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c \u0645\u062b\u0644 \u0627\u0644\u062d\u0627\u062c\u0632 \u0627\u0644\u0638\u0647\u0627\u0631\u064a \u0644\u0644\u0642\u0631\u0646\u064a\u0629. <\/span>\u0633\u062e\u0651\u0627\u0646 \u0645\u0639 \u062d\u0645\u0627\u0645 \u0645\u0627\u0626\u064a \u0645\u0632\u0648\u0651\u062f \u0628\u062d\u0633\u0627\u0633(Thermocouple) \u0644\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 37o<\/sup> \u00a0\u00b11 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629. <\/span>\u0645\u062d\u0631\u0643 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0644\u062a\u062d\u0631\u064a\u0643 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0648\u0642\u0627\u0621 \u0641\u064a \u0627\u0644\u062d\u062c\u0631\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0629 \u0628\u0633\u0631\u0639\u0629 50 \u062f\u0648\u0631\u0629 \u0628\u0627\u0644\u062f\u0642\u064a\u0642\u0629. <\/span>\u062a\u0645\u0651 \u0633\u062d\u0628 \u0623\u062d\u062c\u0627\u0645 \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a(2 \u0645\u0644) \u0648\u0627\u0633\u062a\u0628\u062f\u0627\u0644\u0647\u0627 \u0628\u062d\u062c\u0645 \u0645\u0633\u0627\u0648\u064d \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a pH 7.4. \u062a\u0645\u0651\u062a \u0645\u0642\u0627\u064a\u0633\u0629 \u0643\u0645\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0639\u0646\u062f \u0645\u0648\u062c\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 248 \u0646\u0627\u0646\u0648\u0645\u062a\u0631 \u0645\u0642\u0627\u0628\u0644 \u0634\u0627\u0647\u062f \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 (pH=7.4).<\/span><\/p>\n

\"\u0627\u0644\u0634\u0643\u0644
\u0627\u0644\u0634\u0643\u0644 2: \u062e\u0644\u064a\u0629 \u0641\u0631\u0627\u0646\u0632 \u0645\u062d\u0644\u064a\u0629 \u0627\u0644\u0635\u0646\u0639<\/strong><\/figcaption><\/figure>\n

\u062f\u0631\u0627\u0633\u0629 \u062d\u0631\u0627\u0626\u0643 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 <\/strong>\u00a0<\/strong>kinetic analysis of drug release<\/strong>(14)<\/span><\/p>\n

\u062a\u0645\u0651\u062a \u062f\u0631\u0627\u0633\u0629 \u0623\u0646\u0645\u0627\u0637 \u0631\u064a\u0627\u0636\u064a\u0629 \u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0646 \u0645\u062e\u062a\u0644\u0641 \u0635\u064a\u063a \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629\u060c \u0648\u0641\u0642 \u0639\u062f\u0629 \u0646\u0645\u0627\u0630\u062c \u0644\u0644\u062a\u062d\u0631\u0631\u060c \u062a\u0645\u0651 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c \u0645\u0627\u064a\u0643\u0631\u0648\u0633\u0648\u0641\u062a Excel 2019\u060c \u062a\u0645\u0651 \u062d\u0633\u0627\u0628 \u0642\u064a\u0645 \u0645\u0639\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 (R\u00b2<\/sup>) \u0648\u0641\u0642 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062a\u0627\u0644\u064a\u0629:<\/span><\/p>\n

    \n
  1. \u0646\u0645\u0637 \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0631\u062a\u0628\u0629 \u0635\u0641\u0631 (Zero order release model)<\/span><\/li>\n
  2. \u0646\u0645\u0637 \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0631\u062a\u0628\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 (First order release model)<\/span><\/li>\n
  3. \u0646\u0645\u0637 \u0627\u0644\u062a\u062d\u0631\u0631 \u0648\u0641\u0642 \u0647\u064a\u0643\u0633\u0648\u0646-\u0643\u0631\u0648\u0644 (Hixson-Crowell)<\/span><\/li>\n
  4. 4. \u0646\u0645\u0637 \u0627\u0644\u062a\u062d\u0631\u0631 \u0648\u0641\u0642 \u0647\u064a\u063a\u0648\u0634\u064a (Higuchi release)<\/span><\/li>\n
  5. 5. \u0646\u0645\u0637 \u0627\u0644\u062a\u062d\u0631\u0631 \u0648\u0641\u0642 \u0643\u0648\u0631\u0633\u0645\u0627\u064a\u0631-\u0628\u064a\u0628\u0627\u0633 (Korsmeyer-Peppas)<\/span><\/li>\n<\/ol>\n

    \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0630\u064a \u064a\u0645\u062a\u0627\u0632 \u0628\u0642\u064a\u0645\u0629 \u0645\u0639\u0627\u0645\u0644 \u0627\u0631\u062a\u0628\u0627\u0637 \u0623\u0639\u0644\u0649 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0628\u0642\u064a\u0629 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0647\u0648 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0623\u0643\u062b\u0631 \u0645\u0648\u0627\u0621\u0645\u0629.<\/span><\/p>\n

    \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a<\/strong><\/span><\/p>\n

    \u062a\u0645\u0651 \u0642\u064a\u0627\u0633 \u0639\u064a\u0646\u0627\u062a \u0646\u0642\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0628\u0645\u0641\u0631\u062f\u0647\u0627\u060c \u0623\u0648 \u0628\u0634\u0643\u0644 \u0645\u0632\u0627\u0626\u062c \u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u062b\u0646\u0627\u0626\u064a\u0629\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u064a\u0641 \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0645\u0646 \u0646\u0648\u0639 (Bruker IR 10049361, Germany) \u0648\u0630\u0644\u0643 \u0636\u0645\u0646 \u0627\u0644\u0645\u062c\u0627\u0644 (400-4000) \u0633\u0645-1<\/sup>. <\/span>\u0625\u0630 \u062a\u0645\u0651 \u0627\u0644\u0645\u0633\u062d \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0644\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0647\u0648\u064a\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0648\u0627\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 (50:50)%\u060c \u0628\u0647\u062f\u0641 \u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0631\u0651\u064a \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062d\u062f\u0648\u062b \u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0635\u064a\u0627\u063a\u0629 \u0627\u0644\u0623\u0641\u0644\u0627\u0645.<\/span><\/p>\n

    \u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong>Results<\/strong><\/span><\/p>\n

    \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0628\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a:<\/strong><\/span><\/p>\n

    \u062a\u0628\u064a\u0646 \u0645\u0646 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 200-400 \u0646\u0627\u0646\u0648\u0645\u062a\u0631 \u0623\u0646 \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a 248 \u0646\u0627\u0646\u0648\u0645\u062a\u0631\u060c \u0648\u0647\u0630\u0627 \u0648\u0627\u0641\u0642 \u0645\u0627 \u0648\u062c\u062f\u0647 \u0644\u0640Sajeev \u00a0\u0648\u0632\u0645\u0644\u0627\u0624\u0647 (6). \u0648\u064a\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0645\u062f\u0631\u0648\u0633.<\/span><\/p>\n

    \"\"<\/p>\n

    \u0627\u062e\u062a\u0628\u0627\u0631 \u062a\u062c\u0627\u0646\u0633 \u0627\u0644\u0645\u062d\u062a\u0648\u0649<\/strong>content uniformity <\/strong><\/span><\/p>\n

    \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 2\u060c \u0623\u0646 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0644\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 (94 \u2013 98)%<\/span><\/p>\n

    \"\"<\/div>\n

    \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0637\u064a <\/strong>folding endurance<\/strong><\/span><\/p>\n

    \u062a\u0631\u0627\u0648\u062d\u062a \u0642\u064a\u0645 \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0637\u064a \u0644\u0644\u0623\u0641\u0644\u0627\u0645 \u0628\u064a\u0646 (350-150) \u0643\u0645\u0627 \u0647\u0648 \u0648\u0627\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 3\u060c \u0648\u0627\u062e\u062a\u0644\u0641 \u0648\u0641\u0642\u0627\u064b \u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 \u0648\u0627\u0644\u0645\u0644\u062f\u0651\u0646. <\/span>\u0648\u0647\u0630\u0627 \u064a\u0628\u064a\u0646 \u0623\u0646 \u0625\u0636\u0627\u0641\u0629 PEG400 \u0643\u0639\u0627\u0645\u0644 \u0645\u0644\u062f\u0646 \u0642\u062f \u0633\u0627\u0647\u0645 \u0641\u064a \u0625\u0639\u0637\u0627\u0621 \u0623\u0641\u0644\u0627\u0645 \u0645\u0631\u0646\u0629 \u0645\u0646\u0627\u0633\u0628\u0629 \u062a\u062a\u062d\u0645\u0644 \u0634\u0631\u0648\u0637 \u0627\u0644\u062a\u062d\u0636\u064a\u0631 \u0648\u0627\u0644\u0646\u0642\u0644 \u0648\u0627\u0644\u062a\u062e\u0632\u064a\u0646 \u0648\u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0639\u064a\u0646\u064a\u060c \u0648\u062d\u0631\u0643\u0629 \u0627\u0644\u0623\u062c\u0641\u0627\u0646.<\/span><\/p>\n

    \"\"<\/p>\n

    \u0642\u0628\u0637 \u0627\u0644\u0631\u0637\u0648\u0628\u0629<\/strong> moisture uptake <\/strong><\/span><\/p>\n

    \u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0635 \u0628\u0639\u062f \u0627\u0644\u062d\u0641\u0638 \u0644\u062b\u0644\u0627\u062b\u0629 \u0623\u064a\u0627\u0645\u060c \u0623\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 A6 \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u0629 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0643\u0628\u0631 \u0645\u0646 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 HPMC k15m\u060c<\/strong> PVP-k30 \u0643\u0627\u0646\u062a \u0627\u0644\u0623\u0643\u062b\u0631 \u0642\u0628\u0637\u0627\u064b \u0644\u0644\u0631\u0637\u0648\u0628\u0629. \u0627\u0644\u062c\u062f\u0648\u0644 (4)\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0642\u0628\u0637 \u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0628\u0639\u062f \u062b\u0644\u0627\u062b\u0629 \u0623\u064a\u0627\u0645 (5.3%) \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0635\u064a\u063a\u0629 A1 \u0623\u0642\u0644 \u0642\u0628\u0637\u0627\u064b \u0644\u0644\u0631\u0637\u0648\u0628\u0629 (0.75%). \u062d\u064a\u062b \u0627\u0632\u062f\u0627\u062f\u062a \u0642\u062f\u0631\u0629 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0639\u0644\u0649 \u0642\u0628\u0637 \u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0628\u0627\u0632\u062f\u064a\u0627\u062f \u0646\u0633\u0628 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0634\u0643\u0651\u0644\u0629 \u0644\u0647\u0627 .<\/span><\/p>\n

    <\/div>\n

    \"\"<\/p>\n

    \u0641\u0642\u062f \u0627\u0644\u0631\u0637\u0648\u0628\u0629<\/strong> moisture loss<\/strong> \u0645\u0646 \u0627\u0644\u0623\u0641\u0644\u0627\u0645<\/strong><\/span><\/p>\n

    \u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0635 \u0628\u0639\u062f \u0627\u0644\u062d\u0641\u0638 \u0644\u062b\u0644\u0627\u062b\u0629 \u0623\u064a\u0627\u0645\u060c \u0623\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 A6 \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u0629 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0643\u0628\u0631 \u0645\u0646 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 \u0643\u0627\u0646\u062a \u0627\u0644\u0623\u0643\u062b\u0631 \u0641\u0642\u062f\u0627\u064b \u0644\u0644\u0631\u0637\u0648\u0628\u0629\u060c \u0627\u0644\u062c\u062f\u0648\u0644 (5)\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u062a\u0644\u0643 \u0627\u0644\u0646\u0633\u0628\u0629 \u0628\u0639\u062f \u062b\u0644\u0627\u062b\u0629 \u0623\u064a\u0627\u0645 (10.9%)\u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0635\u064a\u063a\u0629 A1 \u0627\u0644\u0623\u0642\u0644 \u0641\u0642\u062f\u0627\u064b \u0644\u0644\u0631\u0637\u0648\u0628\u0629 (1.29%)\u060c \u062d\u064a\u062b \u0627\u0632\u062f\u0627\u062f \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0641\u0644\u0645 \u0644\u0644\u0631\u0637\u0648\u0628\u0629 \u0645\u0639 \u0632\u064a\u0627\u062f\u0629 \u0646\u0633\u0628\u0629 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0634\u0643\u0651\u0644\u0629 \u0644\u0647\u0627.<\/span><\/p>\n

    \"\"<\/p>\n

    \u062f\u0631\u062c\u0629 \u0628\u0627\u0647\u0627\u0621 \u0627\u0644\u0633\u0637\u062d <\/strong>\u00a0<\/strong>(pH of the surface)<\/strong>\u0644\u0644\u0623\u0641\u0644\u0627\u0645<\/strong><\/span><\/p>\n

    \u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 6 \u0623\u0646 \u062f\u0631\u062c\u0629 \u0628\u0627\u0647\u0627\u0621 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062a\u0631\u0627\u0648\u062d\u062a \u0645\u0646 5.1 \u062d\u062a\u0649 5.8\u060c \u0648\u0647\u064a \u062a\u064f\u0639\u062f \u0645\u062d\u062a\u0645\u0644\u0629 \u0648\u063a\u064a\u0631 \u0645\u062e\u0631\u0634\u0629 \u0644\u0644\u0639\u064a\u0646 \u0646\u0638\u0631\u0627\u064b \u0644\u0623\u0646\u0647\u0627 \u062a\u0642\u0639 \u0636\u0645\u0646 \u0645\u062c\u0627\u0644 \u0627\u0644\u0640 pH {4-10} \u0644\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062a\u064a \u062a\u0646\u0627\u0633\u0628 \u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0639\u064a\u0646\u064a. (15)<\/span><\/p>\n

    \"\"<\/p>\n

    \u062b\u062e\u0627\u0646\u0629 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 <\/strong>(<\/strong>Thickness of films)<\/strong><\/span><\/p>\n

    \u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 7 \u0628\u0623\u0646 \u062b\u062e\u0627\u0646\u0629 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062a\u0631\u0627\u0648\u062d\u062a \u0628\u064a\u0646 (0.4-0.1) \u0645\u0644\u0645.<\/span><\/p>\n

    \"\"<\/p>\n

    \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c <\/strong>In vitro<\/em><\/strong> drug release <\/strong><\/span><\/p>\n

    \u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0648\u0644 8 \u0645\u0639\u062f\u0644\u0627\u062a \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0646 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0651\u0631\u0629. <\/span>\u0643\u0627\u0646\u062a \u0627\u0644\u0635\u064a\u063a\u0629 A6 \u0627\u0644\u0623\u0628\u0637\u0623 \u062a\u062d\u0631\u0631\u0627\u064b \u0645\u0646 \u0628\u064a\u0646 \u0635\u064a\u063a \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0645\u062d\u0636\u0651\u0631\u0629\u060c \u062d\u064a\u062b \u0627\u0633\u062a\u0645\u0631 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0646\u0647\u0627 \u062d\u062a\u0649 6 \u0633\u0627\u0639\u0627\u062a <\/span>\u0628\u064a\u0646\u0645\u0627 \u0627\u0633\u062a\u0645\u0631 \u0627\u0644\u062a\u062d\u0631\u0631 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 A5 \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u0629 \u0646\u0633\u0628 \u0623\u0642\u0644 \u0645\u0646 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u0634\u0643\u0644\u0629 \u0644\u0644\u0641\u0644\u0645 \u0623\u0631\u0628\u0639 \u0633\u0627\u0639\u0627\u062a\u060c \u0623\u0645\u0627 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 A4 \u0648 A3 \u0641\u0642\u062f \u0627\u0633\u062a\u0645\u0631 \u0627\u0644\u062a\u062d\u0631\u0631 \u0644\u0645\u062f\u0629 \u0633\u0627\u0639\u062a\u064a\u0646\u060c \u0628\u064a\u0646\u0645\u0627 \u062a\u062d\u0631\u0631\u062a \u0643\u0627\u0645\u0644 \u0643\u0645\u064a\u0629 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 A2 \u0648 A1 \u062e\u0644\u0627\u0644 \u0633\u0627\u0639\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u0642\u0637. \u062d\u064a\u062b \u0625\u0646\u0651 \u0627\u0632\u062f\u064a\u0627\u062f \u062a\u0631\u0643\u064a\u0632 PVP-k30 \u064a\u0632\u064a\u062f \u0645\u0646 \u0632\u0645\u0646 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0648\u0647\u0630\u0627 \u064a\u0648\u0627\u0641\u0642 \u0645\u0627 \u062a\u0648\u0635\u0644 \u0625\u0644\u064a\u0647 Khan \u0648\u0632\u0645\u0644\u0627\u0624\u0647(2021) \u062d\u064a\u062b \u064a\u062d\u062f\u062b \u0625\u0645\u0627\u0647\u0629 \u0644\u0644\u0641\u0644\u0645 \u0639\u0646\u062f \u0645\u0644\u0627\u0645\u0633\u062a\u0647 \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 (16).<\/span><\/p>\n

    \u062f\u0631\u0627\u0633\u0629 \u062d\u0631\u0627\u0626\u0643 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a<\/strong> kinetic analysis of drug release<\/strong> \u0645\u0646 \u0627\u0644\u0623\u0641\u0644\u0627\u0645<\/strong><\/span><\/p>\n

    \u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 9 \u0642\u064a\u0645 \u0645\u0639\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 R2<\/sup>\u060c \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0631\u062a\u0628\u0629 \u0635\u0641\u0631\u060c \u0627\u0644\u0631\u062a\u0628\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u060c \u0647\u0643\u0633\u0648\u0646-\u0643\u0631\u0648\u0644\u060c \u0647\u064a\u063a\u0648\u062a\u0634\u064a\u060c \u0643\u0648\u0631\u0633\u0645\u0627\u064a\u0631 \u0628\u064a\u0628\u0627\u0633 \u0644\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0645\u062d\u0636\u0631\u0629. <\/span>\u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 \u0627\u0644\u0635\u064a\u063a A1\u060cA2\u060c \u00a0A3\u060c A4\u060c A5\u060c A6 \u062a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0627\u0644\u0631\u062a\u0628\u0629 \u0635\u0641\u0631 \u0644\u0644\u062a\u062d\u0631\u0631\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645 \u0645\u0639\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0623\u0639\u0644\u0649 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0628\u0642\u064a\u0629 \u0627\u0644\u0623\u0646\u0645\u0627\u0637\u060c \u0623\u064a \u0623\u0646\u0651 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0645\u0637\u0631\u0633 \u062b\u0627\u0628\u062a \u062e\u0644\u0627\u0644 \u0627\u0644\u0632\u0645\u0646\u060c \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0627\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u0636\u0628\u0648\u0637. <\/span>\u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646 \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 A2 \u064a\u062a\u0648\u0627\u0641\u0642 \u0623\u064a\u0636\u0627\u064b \u0645\u0639 \u0646\u0645\u0637 Korsmeyer-Peppas \u0644\u0644\u062a\u062d\u0631\u0631 \u0648\u062a\u0645 \u062d\u0633\u0627\u0628 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0623\u0633\u064a \u00a0n \u0648\u0627\u0644\u0630\u064a \u0643\u0627\u0646 \u0628\u064a\u0646 (0.7-0.83) \u0648\u0647\u0630\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0623\u0646 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0634\u0627\u0630 \u0648\u0644\u0627 \u064a\u062a\u0628\u0639 \u0642\u0627\u0646\u0648\u0646 \u0641\u064a\u0643 \u0644\u0644\u0627\u0646\u062a\u0634\u0627\u0631 (Non-Fickan transport) \u0648\u064a\u062a\u062d\u0643\u0645 \u0628\u0647 \u0646\u0641\u0648\u0630\u064a\u0629 \u0627\u0644\u0641\u0644\u0645 \u0648\u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0639\u0628\u0631 \u0633\u0644\u0627\u0633\u0644 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0648\u0627\u0646\u062a\u0628\u0627\u062c \u0648\u062a\u0622\u0643\u0644 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0645\u0639\u0627\u064b (17) <\/span>\u062d\u064a\u062b \u064a\u0634\u0631\u062d \u0646\u0645\u0637 \u0643\u0648\u0631\u0633\u0645\u0627\u064a\u0631- \u0628\u064a\u0628\u0627\u0633(Korsmeyer-Peppas) \u0639\u0644\u0627\u0642\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0622\u0644\u064a\u0629 \u062a\u062d\u0631\u0631\u0647 \u0648\u064a\u064f\u0639\u0637\u0649 \u0648\u0641\u0642 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0622\u062a\u064a\u0629:<\/span><\/p>\n

    Qt<\/sub> =a.tn<\/sup><\/span><\/p>\n

    \u062d\u064a\u062b \u0625\u0646\u0651\u064e Qt \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0639\u0646\u062f \u0627\u0644\u0632\u0645\u0646 t\u060c \u0648 a \u062b\u0627\u0628\u062a\u0629 \u062a\u0639\u0628\u0631 \u0639\u0646 \u0627\u0644\u062e\u0648\u0627\u0635 \u0627\u0644\u0647\u0646\u062f\u0633\u064a\u0629 geometric \u0644\u0644\u0634\u0643\u0644 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u060c \u0628\u064a\u0646\u0645\u0627 n \u0623\u0633 \u0627\u0644\u062a\u062d\u0631\u0631 \u0623\u0648 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0648\u0627\u0644\u062a\u064a \u062a\u062f\u0644 \u0639\u0644\u0649 \u0646\u0645\u0637 \u0627\u0644\u062a\u062d\u0631\u0631\u060c \u0648 t \u0627\u0644\u0632\u0645\u0646(\u0633\u0627\u0639\u0629). <\/span>\u062a\u064f\u062d\u0633\u0628 \u0642\u064a\u0645\u0629 n \u0645\u0646 \u0627\u0644\u062e\u0637 \u0627\u0644\u0628\u064a\u0627\u0646\u064a \u0627\u0644\u0645\u0631\u0633\u0648\u0645 \u0628\u064a\u0646 log(Qt<\/sub>) \u0648 log(t).<\/span><\/p>\n

    \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a<\/strong><\/span><\/p>\n

    \u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 4 \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a\u060c \u0643\u0645\u0627 \u064a\u064f\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 5 \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0640 (HPMC k15m) \u0648\u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a. \u0643\u0645\u0627 \u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 6 \u0637\u064a\u0641 IR \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0640 (PVP-k30) \u0648\u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a\u060c \u0648\u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 7 \u0637\u064a\u0641 IR \u00a0\u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0640 (PEG 400) \u0648\u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a.<\/span><\/p>\n

    <\/div>\n
    \"\"<\/div>\n
    \"\"<\/div>\n
    <\/div>\n
    \n
    \"\u0627\u0644\u0634\u0643\u0644
    \u0627\u0644\u0634\u0643\u0644 4: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a<\/strong><\/figcaption><\/figure>\n<\/div>\n

    \u064a\u064f\u0628\u064a\u0651\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 10 \u0623\u0647\u0645 \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0648\u0635\u0641\u064a\u0651\u0629 \u0641\u064a \u0637\u064a\u0641 IR \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u0647\u0627.<\/span><\/p>\n

    \"\"<\/p>\n

    \u0628\u064f\u0638\u0647\u0631 \u0637\u064a\u0641 FTIR \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0642\u0645\u0651\u0629 \u0645\u0645\u064a\u0632\u0629 \u0639\u0646\u062f 1589 \u0633\u0645-1<\/sup> \u062a\u0642\u0627\u0628\u0644 \u0627\u0647\u062a\u0632\u0627\u0632 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u2013NH \u0644\u0644\u0625\u064a\u0645\u064a\u062f\u0627\u0632\u0648\u0644. \u0648\u0639\u064f\u062b\u0631 \u0639\u0644\u0649 \u0642\u0645\u0651\u0629 \u0642\u062f \u062a\u064f\u0639\u0632\u0649 \u0644\u0627\u0647\u062a\u0632\u0627\u0632\u0627\u062a \u0627\u0644\u0627\u0645\u062a\u0637\u0627\u0637 \u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a C = N \u0648 C = C \u0639\u0646\u062f 1260 \u0633\u0645-1<\/sup> \u0648 1647 \u0633\u0645-1<\/sup> \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0643\u0645\u0627 \u0638\u0647\u0631\u062a \u0627\u0647\u062a\u0632\u0627\u0632\u0627\u062a \u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0629 C = O \u0639\u0646\u062f 1725 \u0633\u0645-1<\/sup>. \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0646\u062a\u0627\u0626\u062c Abu Rahma \u0648\u0632\u0645\u0644\u0627\u0626\u0647 (18) \u0648Sharma \u0648\u0632\u0645\u0644\u0627\u0626\u0647 (19). <\/span><\/p>\n

    \"\u0627\u0644\u0634\u0643\u0644
    \u0627\u0644\u0634\u0643\u0644 5: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0640 (HPMC k15m) \u0648\u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a<\/strong><\/figcaption><\/figure>\n
    \"\u0627\u0644\u0634\u0643\u0644
    \u0627\u0644\u0634\u0643\u0644 6: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a (PVP-k30 + BRT)<\/strong><\/figcaption><\/figure>\n
    \"\u0627\u0644\u0634\u0643\u0644
    \u0627\u0644\u0634\u0643\u0644 7: \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a (PEG 400 + BRT)<\/strong><\/figcaption><\/figure>\n

    \u064a\u064f\u0644\u0627\u062d\u0638 \u0641\u064a \u0627\u0644\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0644\u0644\u0623\u0645\u0632\u062c\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0639 \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0628\u0642\u0627\u0621 \u0627\u0644\u0639\u064f\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u062f\u0627\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0641\u064a \u0635\u064a\u063a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0647\u0630\u0627 \u0642\u062f \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0648\u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646. <\/span>\u062a\u0645 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0636\u064a\u0631 \u0635\u064a\u063a \u0623\u0641\u0644\u0627\u0645 \u0630\u0648\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0648\u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0646\u0647\u0627\u060c \u0648\u062a\u062d\u062f\u064a\u062f \u062e\u0648\u0627\u0635\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0648\u0623\u0646\u0645\u0627\u0637 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646\u0647\u0627\u060c \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 \u0627\u0632\u062f\u064a\u0627\u062f \u0646\u0633\u0628\u0629 HPMC k15m \u0648 PVP-k30 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u063a \u064a\u064f\u0645\u0643\u0646 \u0623\u0646 \u064a\u0632\u064a\u062f \u0645\u0646 \u0632\u0645\u0646 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a.<\/span><\/p>\n

    \u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong><\/span><\/p>\n

    \u062c\u0631\u0649 \u062a\u062d\u0636\u064a\u0631 6 \u0635\u064a\u063a \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0627\u0644\u0630\u0648\u0627\u0628\u0629\u060c \u0644\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0644\u0645\u0631\u0627\u062a \u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 (HPMC k15m\u060cPVP-k30) \u0648\u0630\u0644\u0643 \u0628\u0625\u0636\u0627\u0641\u062a\u0647\u0627 \u0628\u0646\u0633\u0628 \u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u062a\u0645\u0651\u062a \u0625\u0636\u0627\u0641\u0629 PEG 400 \u0628\u0646\u0633\u0628\u0629 \u062b\u0627\u0628\u062a\u0629. \u0643\u0627\u0646 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 A6 \u0627\u0644\u0623\u0637\u0648\u0644 \u062a\u062d\u0631\u0631\u0627 \u064b\u062d\u064a\u062b \u0627\u0633\u062a\u0645\u0631 \u0644\u0645\u062f\u0629 6 \u0633\u0627\u0639\u0627\u062a \u0628\u064a\u0646\u0645\u0627 \u0627\u0633\u062a\u0645\u0631 \u0644\u0645\u062f\u0629 4 \u0633\u0627\u0639\u0627\u062a \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 A5 \u0623\u0645\u0627 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 A3 \u00a0\u0648 A4 \u0641\u0642\u062f \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u062e\u0644\u0627\u0644 \u0633\u0627\u0639\u062a\u064a\u0646\u060c \u0648\u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 A1 \u0648 A2 \u062e\u0644\u0627\u0644 \u0633\u0627\u0639\u0629 \u0648\u0627\u062d\u062f\u0629. \u0625\u0646\u0651 \u0632\u064a\u0627\u062f\u0629 \u0646\u0633\u0628\u0629 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0632\u0627\u062f \u0645\u0646 \u0632\u0645\u0646 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a \u0645\u0646 \u0627\u0644\u0623\u0641\u0644\u0627\u0645 \u0643\u0645\u0627 \u0627\u062e\u062a\u0644\u0641\u062a \u0646\u0633\u0628 \u0641\u0642\u062f \u0627\u0644\u0631\u0637\u0648\u0628\u0629 \u0648\u0642\u0628\u0637\u0647\u0627 \u0648\u062b\u062e\u0627\u0646\u0629 \u0627\u0644\u0623\u0641\u0644\u0627\u0645. \u0643\u0627\u0646 \u062a\u062d\u0631\u0631 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0631\u062a\u0628\u0629 \u0635\u0641\u0631\u060c \u0623\u064a \u0623\u0646 \u0627\u0644\u062a\u062d\u0631\u0631 \u062b\u0627\u0628\u062a \u062e\u0644\u0627\u0644 \u0627\u0644\u0632\u0645\u0646 \u0648\u0647\u0648 \u064a\u0639\u062f \u0646\u0645\u0637\u0627\u064b \u0645\u0641\u0636\u0644\u0627\u064b \u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u064a\u0646\u064a\u0629.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u064a\u0639\u062f \u0627\u0644\u0632\u0631\u0642 \u0645\u0646 \u0623\u0634\u064a\u0639 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u062a\u064a \u062a\u0635\u064a\u0628 \u0627\u0644\u0639\u064a\u0646 \u0643\u0645\u0627 \u0623\u0646\u0647\u0627 \u0627\u0644\u0645\u0633\u0628\u0628 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0639\u0645\u0649 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 (1)\u060c \u0625\u0646\u0651 \u0627\u0644\u0628\u0631\u064a\u0645\u0648\u0646\u064a\u062f\u064a\u0646 \u0637\u0631\u0637\u0631\u0627\u062a…
    \u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":783,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-123","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-134","volume-9","year-137"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=123"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/123\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/783"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}