{"id":146,"date":"2023-07-01T11:31:37","date_gmt":"2023-07-01T11:31:37","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=146"},"modified":"2024-07-13T15:25:46","modified_gmt":"2024-07-13T15:25:46","slug":"%d8%a7%d9%84%d8%a8%d8%b1%d9%88%d8%aa%d9%8a%d9%86-%d8%a7%d9%84%d8%a7%d9%8a%d9%88%d8%b2%d9%8a%d9%86%d9%8a%d9%91-%d8%a7%d9%84%d9%83%d8%a7%d8%aa%d9%8a%d9%88%d9%86%d9%8a%d9%91-ecp-%d9%88%d8%a7%d8%b5%d9%85","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=146","title":{"rendered":"\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a\u0651 \u0627\u0644\u0643\u0627\u062a\u064a\u0648\u0646\u064a\u0651 ECP \u0648\u0627\u0635\u0645\u0627\u064b \u062d\u064a\u0648\u064a\u0627\u064b \u0644\u062a\u0641\u0639\u064a\u0644 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0641\u064a \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f\u064a \u0627\u0644\u0645\u0632\u0645\u0646 COPD"},"content":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction<\/span><\/strong><\/p>\n

\u064a\u064f\u0639\u0631\u0651\u064e\u0641 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f\u064a \u0627\u0644\u0645\u0632\u0645\u0646 \u0623\u0646\u0647 \u0645\u0631\u0636\u064c \u0634\u0627\u0626\u0639 \u064a\u0645\u0643\u0646 \u062a\u062f\u0628\u064a\u0631\u0647 \u0648\u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646\u0647\u060c \u064a\u062a\u0631\u0627\u0641\u0642 \u0645\u0639 \u0623\u0639\u0631\u0627\u0636 \u062a\u0646\u0641\u0633\u064a\u0629 \u062f\u0627\u0626\u0645\u0629 \u0623\u0628\u0631\u0632\u0647\u0627 \u0627\u0644\u0632\u0644\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0648\u0627\u0644\u0633\u0639\u0627\u0644 \u0627\u0644\u0645\u0646\u062a\u062c\u060c \u0648\u064a\u062a\u0645\u064a\u0632 \u0628\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0645\u0632\u0645\u0646\u0629 \u0641\u064a \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u062d\u062f\u062f (\u062a\u0636\u064a\u0651\u0642) \u0644\u0627 \u0639\u0643\u0648\u0633 \u0641\u064a \u0627\u0644\u0645\u062c\u0631\u0649 \u0627\u0644\u0647\u0648\u0627\u0626\u064a [1, 2]\u060c \u0648\u064a\u0634\u0643\u0651\u0644 \u0647\u0630\u0627 \u0627\u0644\u062f\u0627\u0621 \u0633\u0628\u0628\u064b\u0627 \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0644\u0644\u0645\u0631\u0627\u0636\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u062a\u0629\u060c \u0625\u0630 \u064a\u062d\u062a\u0644 \u0627\u0644\u0645\u0631\u062a\u0628\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0628\u064a\u0646 \u0627\u0644\u0623\u0633\u0628\u0627\u0628 \u0627\u0644\u0645\u0624\u062f\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u0648\u0641\u0627\u0629 \u0639\u0627\u0644\u0645\u064a\u064b\u0627 [3]\u060c \u0648\u062a\u062e\u062a\u0644\u0641 \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0646\u062a\u0634\u0627\u0631\u0647 \u0645\u0646 \u0628\u0644\u062f \u0625\u0644\u0649 \u0623\u062e\u0631 [1]\u060c \u0648\u062a\u064f\u0639\u064e\u062f \u0633\u0648\u0631\u064a\u0651\u0629 \u0630\u0627\u062a \u0623\u0639\u0644\u0649 \u0645\u0639\u062f\u0644 \u0627\u0646\u062a\u0634\u0627\u0631 \u0644\u0644\u0640COPD \u0641\u064a \u062f\u0648\u0644 \u0627\u0644\u0634\u0631\u0642 \u0627\u0644\u0623\u0648\u0633\u0637 [4]. <\/span>\u064a\u0639\u062a\u0645\u062f \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0640COPD \u0639\u0644\u0649 \u062a\u0623\u0643\u064a\u062f \u0648\u062c\u0648\u062f \u0627\u0644\u062a\u062d\u062f\u062f \u0627\u0644\u0647\u0648\u0627\u0626\u064a \u0627\u0644\u0644\u0627\u0639\u0643\u0648\u0633 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0646\u0641\u0633 Spirometry\u060c \u0625\u0630 \u062a\u064f\u062d\u0633\u064e\u0628 \u0627\u0644\u0646\u0633\u0628\u0629 \u0645\u0627 \u0628\u064a\u0646 \u0627\u0644\u062d\u062c\u0645 \u0627\u0644\u0632\u0641\u064a\u0631\u064a \u0627\u0644\u0642\u0633\u0631\u064a \u0641\u064a \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 Forced Expiratory Volume In One Second (FEV1)\u060c \u0648\u0627\u0644\u0633\u0639\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0642\u0633\u0631\u064a\u0629 Forced Vital Capacity\u00a0 (FVC) \u0623\u064a FEV1\/FVC\u060c \u0648\u062a\u064f\u0639\u064e\u062f \u0623\u064a \u0646\u0633\u0628\u0629 \u0623\u0642\u0644 \u0645\u0646 0.7 \u0628\u0639\u062f \u0625\u0631\u0630\u0627\u0630 \u0627\u0644\u0645\u0648\u0633\u0639 \u0627\u0644\u0642\u0635\u0628\u064a \u0645\u0634\u062e\u0635\u0629 \u0644\u0644\u0640COPD [2]. <\/span>\u064a\u062a\u0631\u0627\u0641\u0642 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0645\u0639 \u0622\u0648\u0646\u0629 \u062a\u0633\u0648\u0621 \u0641\u064a\u0647\u0627 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0639\u0644\u0649 \u0646\u062d\u0648 \u064a\u0633\u062a\u062f\u0639\u064a \u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c \u0648\u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621\u060c \u0648\u062a\u064f\u062f\u0639\u064e\u0649 \u0647\u0630\u0647 \u0627\u0644\u0641\u062a\u0631\u0627\u062a \u0627\u0644\u0622\u0648\u0646\u0629 \u0628\u0633\u0648\u0631\u0627\u062a (\u0647\u062c\u0645\u0627\u062a) \u0627\u0644\u0640COPD (COPD Exacerbations)\u060c \u0648\u062a\u064f\u0639\u064e\u062f \u0647\u0630\u0647 \u0627\u0644\u0633\u0648\u0631\u0627\u062a \u062d\u062f\u062b\u064b\u0627 \u0645\u0647\u062f\u062f\u064b\u0627 \u0644\u0644\u062d\u064a\u0627\u0629\u060c \u0648\u062a\u062a\u0631\u0627\u0641\u0642 \u0645\u0639 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0648\u062a\u0632\u062f\u0627\u062f \u062c\u0647\u0627\u0632\u064a\u064b\u0627 [1, 2]. <\/span>\u0625\u0646\u0651 \u0622\u0644\u064a\u0629 COPD \u0627\u0644\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u063a\u064a\u0631 \u0645\u0641\u0647\u0648\u0645\u0629 \u062c\u064a\u062f\u0627\u064b\u060c \u0648\u0644\u0643\u0646 \u0639\u0627\u062f\u0629\u064b \u0645\u0627 \u062a\u0643\u0648\u0646 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0627\u0633\u0637\u0629 \u0628\u0627\u0644\u0639\u062f\u0644\u0627\u062a \u0647\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u0645\u0633\u064a\u0637\u0631\u0629 \u0641\u064a\u0647 [5]\u060c \u0648\u0645\u0639 \u0630\u0644\u0643 \u0641\u0642\u062f \u062a\u0634\u0627\u0631\u0643 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0648\u0642\u062f \u062a\u062d\u062f\u062b \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0623\u0639\u062f\u0627\u062f \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0640COPD [5-7]\u060c \u0645\u0627 \u0642\u062f \u064a\u062a\u0631\u0627\u0641\u0642 \u0645\u0639 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0636\u0645\u0646 \u062d\u0628\u064a\u0628\u0627\u062a\u0647\u0627\u060c \u0645\u0627 \u064a\u0648\u062d\u064a \u0628\u062d\u062f\u0648\u062b \u062a\u0641\u0639\u064a\u0644 \u0644\u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u060c \u0648\u0645\u0634\u0627\u0631\u0643\u062a\u0647\u0627 \u0647\u064a \u0648\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a\u0647\u0627 \u0627\u0644\u0645\u0641\u0631\u064e\u0632\u064e\u0629 \u0641\u064a \u0631\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0645\u0645\u064a\u0632 \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 [8]\u060c \u0648\u0645\u0627 \u064a\u062f\u0639\u0645 \u0647\u0630\u0647 \u0627\u0644\u0641\u0631\u0636\u064a\u0629 \u0623\u0646\u0651 \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 \u062b\u0644\u062b \u0645\u0631\u0636\u0649 \u0627\u0644\u0640COPD \u064a\u0628\u062f\u0648\u0646 \u0646\u0645\u0637\u064b\u0627 \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u064b\u0627 \u062d\u0627\u0645\u0636\u064a\u064b\u0627\u060c \u0623\u064a \u062a\u0633\u0648\u062f \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0627\u0633\u0637\u0629 \u0628\u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0639\u0644\u0649 \u0646\u062d\u0648 \u0645\u0634\u0627\u0628\u0647 \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0631\u0628\u0648 [2, 5]\u060c \u0648\u0645\u0646 \u062b\u0645\u0651\u064e \u0641\u0645\u0646 \u0627\u0644\u0645\u0641\u064a\u062f \u062f\u0631\u0627\u0633\u0629 \u062f\u0648\u0631 \u062a\u0641\u0639\u064a\u0644 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0648\u0644\u064a\u0633 \u0641\u0642\u0637 \u062a\u0639\u062f\u0627\u062f\u0647\u0627 \u0641\u064a \u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0627\u0644\u0640COPD\u060c \u0644\u0641\u0647\u0645 \u0622\u0644\u064a\u062a\u0647 \u0627\u0644\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0641\u0647\u0645\u0627\u064b \u0623\u0641\u0636\u0644 \u0648\u0645\u0646 \u062b\u0645\u0651\u064e \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0644\u0647. <\/span>\u064a\u0648\u062c\u062f \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a \u0627\u0644\u0643\u0627\u062a\u064a\u0648\u0646\u064a ECP \u0636\u0645\u0646 \u062d\u0628\u064a\u0628\u0627\u062a \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0627\u0644\u0642\u0627\u0639\u062f\u064a Major Basic Protein\u060c \u0648\u0627\u0644\u0628\u0631\u0648\u0643\u0633\u064a\u062f\u0627\u0632 \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a Eosinophil Peroxidaxe\u060c \u0648\u0627\u0644\u0633\u0645 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0634\u062a\u0642 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636\u0627\u062a Eosinophil-derived Neurotoxin \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 X \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a Eosinophil Protein X [9]\u060c \u0648\u0644\u0627 \u064a\u064f\u0641\u0631\u064e\u0632 \u0627\u0644\u0640ECP \u0633\u0648\u0649 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0627\u0644\u0645\u064f\u0641\u064e\u0639\u0651\u0644\u0629\u060c \u0648\u0645\u0646 \u062b\u0645\u0651\u064e \u062a\u064f\u0639\u064e\u062f \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u0645\u0634\u0639\u0631\u064b\u0627 \u0644\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u062f\u0648\u0631\u0647 \u0648\u062f\u0648\u0631 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0627\u0644\u0645\u0641\u0639\u0651\u0644\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u062b\u0644 COPD \u0648\u0627\u0644\u0631\u0628\u0648 [9, 10]. <\/span>\u064a\u0628\u062f\u064a ECP \u0641\u0639\u0627\u0644\u064a\u0627\u062a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0639\u062f\u064a\u062f\u0629 \u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0648\u063a\u064a\u0631 \u0627\u0644\u0628\u0634\u0631\u064a\u0629\u060c \u0641\u0647\u0648 \u0630\u0648 \u0641\u0639\u0627\u0644\u064a\u0629 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u062d\u064a\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629\u060c \u0648\u064a\u062a\u0645\u062a\u0639 \u0628\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u063a\u064a\u0631 \u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0641\u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u064a\u0624\u062f\u064a ECP \u062f\u0648\u0631\u064b\u0627 \u0628\u062a\u0646\u0638\u064a\u0645 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u0631\u0648\u0645\u0629 \u0627\u0644\u0644\u064a\u0641\u064a\u0629\u060c \u0648\u064a\u062d\u0631\u0636 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0645\u062e\u0627\u0637\u060c \u0648\u064a\u0642\u0644\u0644 \u0645\u0646 \u062d\u0631\u0643\u0629 \u0627\u0644\u0623\u0647\u062f\u0627\u0628 \u0641\u064a \u0627\u0644\u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629\u060c \u0648\u064a\u062a\u0648\u0627\u0633\u0637 \u062a\u0642\u0644\u0635 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0645\u0644\u0633 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0633\u0628\u0644 \u0623\u064a\u0636\u064b\u0627\u060c \u0643\u0645\u0627 \u064a\u0628\u062f\u064a \u062f\u0648\u0631\u0627\u064b \u0641\u064a \u0625\u0639\u0627\u062f\u0629 \u062a\u0634\u0643\u064a\u0644 (\u0646\u0645\u0630\u062c\u0629) \u0627\u0644\u0646\u0633\u062c \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 tissues remodeling [9, 11]. \u0648\u0639\u0627\u062f\u0629\u064b \u0645\u0627 \u062a\u064f\u0644\u0627\u062d\u064e\u0638 \u0647\u0630\u0647 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0645\u062b\u0644 \u062a\u0642\u0644\u0635 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0645\u0644\u0633 \u0641\u064a \u0627\u0644\u0633\u0628\u064a\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0648\u0641\u0631\u0637 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0645\u062e\u0627\u0637 \u0648\u0625\u0639\u0627\u062f\u0629 \u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0646\u0633\u062c \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0640COPD [1] \u0648\u0645\u0646 \u062b\u0645\u0651\u064e \u0642\u062f \u064a\u0624\u062f\u064a ECP \u062f\u0648\u0631\u064b\u0627 \u0641\u064a \u062d\u062f\u0648\u062b\u0647\u0627 \u0644\u062f\u0649 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649. <\/span>\u062a\u0647\u062f\u0641 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u062f\u0648\u0631 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0627\u0644\u0645\u0641\u0639\u0651\u0644\u0629 \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a \u0627\u0644\u0643\u0627\u062a\u064a\u0648\u0646\u064a ECP \u0641\u064a \u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0627\u0644\u0640COPD \u0648\u062d\u062f\u0648\u062b \u0633\u0648\u0631\u0627\u062a\u0647 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0633\u0648\u0631\u064a\u064a\u0646 \u0628\u0648\u0633\u0627\u0637\u0629 \u062a\u062d\u062f\u064a\u062f \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u062f\u064a\u0647\u0645.<\/span><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong> Materials and methods<\/strong><\/span><\/p>\n

\u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 \u062d\u0627\u0644\u0629 \u0634\u0627\u0647\u062f Case control\u060c \u062a\u0636\u0645\u0646\u062a 87 \u0641\u0631\u062f\u064b\u0627\u060c 20 \u0645\u0646\u0647\u0645 \u0623\u0635\u062d\u0627\u0621 \u0638\u0627\u0647\u0631\u064a\u064b\u0627\u060c 32 \u0645\u0631\u064a\u0636\u064b\u0627 COPD \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 (\u062d\u0627\u0644\u0629 \u0645\u0633\u062a\u0642\u0631\u0629)\u060c \u064835 \u0645\u0631\u064a\u0636\u064b\u0627 COPD \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0633\u0648\u0631\u0629\u060c \u0648\u0648\u064f\u062b\u0650\u0642\u064e\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u0639\u062f\u0629 \u0644\u0643\u0644 \u0641\u0631\u062f \u0645\u0646\u0647\u0645 \u0648\u0627\u0644\u062a\u064a \u0634\u0645\u0644\u062a \u0639\u0645\u0631\u0647\u060c \u0648\u062c\u0646\u0633\u0647\u060c \u0648\u0645\u0646\u0633\u0628 \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0644\u062f\u064a\u0647\u060c \u0641\u0636\u0644\u064b\u0627 \u0639\u0646 \u0639\u062f\u062f \u0623\u064a\u0627\u0645 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0648\u0631\u0627\u062a. <\/span>\u0634\u0645\u0644\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 inclusion criteria \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u064a \u0645\u0631\u064a\u0636 COPD \u0634\u064f\u062e\u0651\u0650\u0635\u064e \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u064a\u0647 \u0628\u0639\u062f \u062a\u0642\u0648\u064a\u0645\u0647 \u0645\u0646 \u0645\u062e\u062a\u0635 \u0627\u0644\u062f\u0627\u062e\u0644\u064a\u0629 \u0627\u0644\u0635\u062f\u0631\u064a\u0629 \u0648\u0625\u062c\u0631\u0627\u0621 \u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0646\u0641\u0633 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649\u060c \u0625\u0630 \u0627\u0639\u062a\u0645\u0650\u062f\u064e\u062a \u0627\u0644\u0646\u0633\u0628\u0629 FEV1\/FVC <0.7 \u0628\u0639\u062f \u0625\u0631\u0630\u0627\u0630 \u0627\u0644\u0645\u0648\u0633\u0639 \u0627\u0644\u0642\u0635\u0628\u064a \u0646\u0633\u0628\u0629\u064b \u062a\u0634\u062e\u064a\u0635\u064a\u0629\u060c \u0623\u0645\u0627 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 \u0641\u0642\u062f \u0646\u064f\u0641\u064a\u064e\u062a \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0647. <\/span>\u0623\u0645\u0627 \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f exclusion criteria \u0641\u0634\u0645\u0644\u062a \u0623\u064a \u0645\u0631\u064a\u0636 \u0644\u062f\u064a\u0647 \u0648\u0627\u062d\u062f \u0623\u0648 \u0623\u0643\u062b\u0631 \u0645\u0645\u0627 \u064a\u0623\u062a\u064a: \u0630\u0628\u062d\u0629 \u0623\u0648 \u0627\u062d\u062a\u0634\u0627\u0621 \u0639\u0636\u0644\u0629 \u0642\u0644\u0628\u064a\u0629\u060c \u0648\u0623\u0645\u0631\u0627\u0636 \u062a\u0646\u0641\u0633\u064a\u0629 \u0622\u062e\u0631\u0649 \u0645\u0627 \u0639\u062f\u0627 COPD (\u0645\u062b\u0644 \u0627\u0644\u0631\u0628\u0648 \u0648\u0627\u0644\u062a\u0644\u064a\u0641 \u0627\u0644\u0631\u0626\u0648\u064a)\u060c \u0648\u0623\u0645\u0631\u0627\u0636 \u062a\u0623\u062a\u0628\u064a\u0629 (\u062a\u062d\u0633\u0633\u064a\u0629)\u060c \u0648\u062a\u0646\u0627\u0648\u0644 \u0623\u062f\u0648\u064a\u0629 \u0633\u062a\u064a\u0631\u0648\u0626\u064a\u062f\u064a\u0629 \u0641\u064a 14 \u064a\u0648\u0645\u064b\u0627 \u0642\u0628\u0644 \u0633\u062d\u0628 \u0627\u0644\u0639\u064a\u0646\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629. <\/span>\u062d\u0635\u0644\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 6\/7\/2021 \u0648\u0628\u0631\u0642\u0645 4042\u060c \u0648\u0623\u064f\u062e\u0650\u0630\u064e\u062a \u0645\u0648\u0627\u0641\u0642\u0629 \u0643\u0644 \u0641\u0631\u062f \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0648\u0633\u0627\u0637\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0645\u0633\u062a\u0646\u064a\u0631\u0629. <\/span>\u062c\u064f\u0645\u0650\u0639\u064e\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0644\u0644\u0623\u0635\u062d\u0627\u0621 \u0648\u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u0645\u062f\u0629 \u0627\u0644\u0648\u0627\u0642\u0639\u0629 \u0628\u064a\u0646 \u0646\u064a\u0633\u0627\u0646\u060c \u0648\u062a\u0634\u0631\u064a\u0646 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2021\u060c \u0625\u0630 \u0628\u064f\u0632\u0650\u0644\u064e 5 \u0645\u0644 \u0645\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0645\u0646 \u0643\u0644 \u0645\u0634\u0627\u0631\u0643 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0623\u0646\u0628\u0648\u0628 \u062c\u0627\u0641\u060c \u0648\u062a\u064f\u0631\u0643 \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629 \u062d\u062a\u0649 \u062a\u0645\u0627\u0645 \u0627\u0644\u062a\u062e\u062b\u0631\u060c \u0648\u0645\u0646 \u062b\u0645\u0651 \u062b\u064f\u0641\u0650\u0644\u064e\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0633\u0631\u0639\u0629 1680 Xg \u0648\u0644\u0645\u062f\u0629 \u062e\u0645\u0633 \u0639\u0634\u0631\u0629 \u062f\u0642\u064a\u0642\u0629\u060c \u0623\u064f\u062e\u0650\u0630\u064e \u0627\u0644\u0645\u0635\u0644 \u0644\u0643\u0644 \u0639\u064a\u0646\u0629 \u0641\u064a\u0645\u0627 \u0628\u0639\u062f\u060c \u0648\u0648\u064f\u0632\u0650\u0639 \u0639\u0644\u0649 \u062b\u0644\u0627\u062b\u0629 \u0623\u0646\u0627\u0628\u064a\u0628 \u0627\u0628\u064a\u0646\u062f\u0631\u0648\u0641 \u0627\u0644\u062a\u064a \u062d\u064f\u0641\u0650\u0638\u064e\u062a \u0641\u064a \u0627\u0644\u062f\u0631\u062c\u0629 80 \u2013 Co \u0625\u0644\u0649 \u062d\u064a\u0646 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629. <\/span>\u0639\u064f\u0648\u064a\u0631\u064e\u062a \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0640ECP \u0628\u0627\u0644\u0627\u0645\u062a\u0632\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0625\u0646\u0632\u064a\u0645 ELISA \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u062a\u064a\u062f\u0629 Human ECP ELISA Kit \u0644\u0634\u0631\u0643\u0629 USCN \u0627\u0644\u0635\u064a\u0646\u064a\u0629\u060c \u0648\u0639\u064f\u0645\u0650\u0644\u064e \u0648\u0641\u0642\u064b\u0627 \u0644\u062a\u0639\u0644\u064a\u0645\u0627\u062a \u0627\u0644\u0634\u0631\u0643\u0629 \u0627\u0644\u0645\u0635\u0646\u0639\u0629.<\/span><\/p>\n

\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629:<\/strong><\/span><\/p>\n

\u0627\u0633\u062a\u064f\u062e\u062f\u0650\u0645\u064e \u0628\u0631\u0646\u0627\u0645\u062c SPSS \u0627\u0644\u0625\u0635\u062f\u0627\u0631 25 \u0648GraphPad Prism 9\u060c \u0644\u0625\u0646\u062c\u0627\u0632 \u0643\u0627\u0645\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629\u060c \u0648\u0639\u064f\u0628\u0651\u0631\u064e \u0639\u0646 \u0627\u0644\u0642\u064a\u0645 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u00b1 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a\u060c \u0648\u0642\u064f\u0648\u0631\u0650\u0646\u064e\u062a \u0642\u064a\u0645 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 Kruskal-Wallis test\u060c \u0648\u0627\u0633\u062a\u064f\u062e\u062f\u0650\u0645\u064e \u0627\u062e\u062a\u0628\u0627\u0631 Mann-Whitney \u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0642\u064a\u0645 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0641\u0642\u0637\u060c \u0623\u0645\u0627 \u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0644\u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0641\u0627\u0633\u062a\u064f\u062e\u062f\u0650\u0645\u064e \u0627\u062e\u062a\u0628\u0627\u0631 chi-square\u060c \u0648\u0627\u0639\u062a\u064f\u0645\u0650\u062f\u064e\u062a \u0642\u064a\u0645\u0629 p < 0.05 \u0628\u0648\u0635\u0641\u0647\u0627 \u0642\u064a\u0645\u0629 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u064b\u0627.<\/span><\/p>\n

\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong>Results<\/strong><\/span><\/p>\n

\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0639\u0627\u0645\u0629 \u0648\u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n

\u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 87 \u0641\u0631\u062f\u0627\u064b\u060c 23 \u0645\u0646 \u0627\u0644\u0625\u0646\u0627\u062b \u064864 \u0645\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0648\u064f\u0632\u0650\u0639\u0648\u0627 \u0641\u064a \u062b\u0644\u0627\u062b \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0631\u0626\u064a\u0633\u064a\u0629\u060c \u0648\u064a\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (1) \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0639\u0627\u0645\u0629 \u0648\u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u0647\u0645 \u062a\u0628\u0639\u0627\u064b \u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a\u0647\u0645.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u0627\u0644\u062c\u062f\u0648\u0644 (1): \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0639\u0627\u0645\u0629 \u0648\u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0645\u062a\u063a\u064a\u0631<\/strong><\/span><\/td>\n\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0635\u062d\u0627\u0621<\/strong><\/span><\/p>\n

n= 20<\/strong><\/span><\/td>\n

\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 <\/strong>COPD<\/strong><\/span><\/p>\n

n = 67<\/strong><\/span><\/td>\n<\/tr>\n

\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0647\u062f\u0623\u0629<\/strong><\/span><\/p>\n

n = 32<\/strong><\/span><\/td>\n

\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u0648\u0631\u0629<\/strong><\/span><\/p>\n

n = 35<\/strong><\/span><\/td>\n<\/tr>\n

\u0627\u0644\u062c\u0646\u0633*<\/strong><\/span><\/p>\n

\u0630\u0643\u0631<\/strong><\/span><\/p>\n

\u0623\u0646\u062b\u0649<\/strong><\/span><\/td>\n

 <\/p>\n

13<\/span><\/p>\n

7<\/span><\/td>\n

 <\/p>\n

25<\/span><\/p>\n

7<\/span><\/td>\n

 <\/p>\n

26<\/span><\/p>\n

9<\/span><\/td>\n<\/tr>\n

\u0627\u0644\u0639\u0645\u0631**<\/strong><\/span><\/td>\n57.25 \u00b1 9.76<\/span><\/td>\n63.22 \u00b1 8.72<\/span><\/td>\n68.94 \u00b1 8.99<\/span><\/td>\n<\/tr>\n
\u0639\u062f\u062f \u0623\u064a\u0627\u0645 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621**<\/strong><\/span><\/td>\n–<\/span><\/td>\n–<\/span><\/td>\n6.86 \u00b1 3.55<\/span><\/td>\n<\/tr>\n
\u062d\u0627\u0644\u0629 \u0627\u0644\u062a\u062f\u062e\u064a\u0646<\/strong><\/span><\/td>\n<\/tr>\n
\u0645\u062f\u062e\u0646 \u062d\u0627\u0644\u064a*<\/strong><\/span><\/td>\n11<\/span><\/td>\n30<\/span><\/td>\n32<\/span><\/td>\n<\/tr>\n
\u0645\u062f\u062e\u0646 \u0633\u0627\u0628\u0642*<\/strong><\/span><\/td>\n0<\/span><\/td>\n0<\/span><\/td>\n1<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u062f\u062e\u0646*<\/strong><\/span><\/td>\n9<\/span><\/td>\n2<\/span><\/td>\n2<\/span><\/td>\n<\/tr>\n
\u0645\u0646\u0633\u0628 \u0627\u0644\u062a\u062f\u062e\u064a\u0646**<\/strong><\/span><\/p>\n

(\u0639\u0644\u0628\u0629 \/ \u0633\u0646\u0629)<\/strong><\/span><\/td>\n

37.45 \u00b1 41.07<\/span><\/td>\n58.97 \u00b1 32.86<\/span><\/td>\n66.14 \u00b1 43.99<\/span><\/td>\n<\/tr>\n
*\u0639\u064f\u0628\u0651\u0631\u064e \u0639\u0646 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645 \u0628\u062a\u0643\u0631\u0627\u0631\u0647\u0627<\/span><\/p>\n

**\u0639\u064f\u0628\u0651\u0631\u064e \u0639\u0646 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u00b1 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0646\u062a\u0627\u0626\u062c \u0645\u0639\u0627\u064a\u0631\u0629 <\/strong>ECP<\/strong> \u0644\u062f\u0649 \u0643\u0627\u0645\u0644 \u0639\u064a\u0646\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629:<\/strong><\/span><\/p>\n

\u0628\u0644\u063a\u062a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 11.35 \u00b1 3.92 \u0646\u063a\/\u0645\u0644\u060c \u0648\u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 COPD \u0627\u0644\u0643\u0644\u064a\u0629 \u00b138.24 7.63 \u0646\u063a\/\u0645\u0644. \u0648\u0644\u062f\u0649 \u062a\u0642\u0633\u064a\u0645 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 COPD \u062a\u0628\u0639\u064b\u0627 \u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u064a\u0647\u0645\u060c \u0643\u0627\u0646\u062a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 33.69 \u00b1 5.73 \u0646\u063a\/\u0645\u0644\u060c \u0648\u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0637\u0648\u0631 \u0627\u0644\u0633\u0648\u0631\u0629 42.4 \u00b1 6.76 \u0646\u063a\/\u0645\u0644.<\/span><\/p>\n

\u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 <\/strong>ECP<\/strong> \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0645\u0631\u0636\u0649 <\/strong>COPD<\/strong> \u0627\u0644\u0643\u0644\u064a\u0629 (<\/strong>n= 67<\/strong>) \u0648\u0627\u0644\u0623\u0635\u062d\u0627\u0621 (<\/strong>n=20<\/strong>):<\/strong><\/span><\/p>\n

\u0644\u064f\u0648\u062d\u0650\u0638\u064e \u0627\u0631\u062a\u0641\u0627\u0639\u064c \u0641\u064a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 COPD \u0627\u0644\u0643\u0644\u064a\u0651\u0629 \u0627\u0644\u062a\u064a \u062a\u0634\u0645\u0644 \u062d\u0627\u0644\u062a\u064a \u0627\u0644\u0647\u062f\u0623\u0629\u060c \u0648\u0627\u0644\u0633\u0648\u0631\u0629 (\u00b138.24 7.63 \u0646\u063a\/\u0645\u0644) \u0648\u0630\u0644\u0643 \u0644\u062f\u0649 \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0628\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 (11.35\u00b13.92 \u0646\u063a\/\u0645\u0644)\u060c \u0648\u0628\u0641\u0627\u0631\u0642 \u0645\u0639\u0646\u0648\u064a \u064a\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u064b\u0627 p = 0.0001.<\/span><\/p>\n

\u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 <\/strong>ECP<\/strong> \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 \u0648\u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0633\u0648\u0631\u0627\u062a \u0648\u0627\u0644\u0623\u0635\u062d\u0627\u0621:<\/strong><\/span><\/p>\n

\u0644\u064f\u0648\u062d\u0650\u0638\u064e \u0627\u0631\u062a\u0641\u0627\u0639 \u0641\u064a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 COPD \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0633\u0648\u0631\u0629 (42.4 \u00b1 6.76 \u0646\u063a\/\u0645\u0644) \u0639\u0646\u062f \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0628\u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 COPD \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 (33.69 \u00b1 5.73 \u0646\u063a\/\u0645\u0644)\u060c \u0644\u062f\u0649 \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0628\u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 (11.35 \u00b1 3.92 \u0646\u063a\/\u0645\u0644) \u0623\u064a\u0636\u064b\u0627\u060c \u0648\u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062b \u0630\u0648 \u0642\u064a\u0645\u0629 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u064b\u0627 p = 0.0001 (\u0627\u0644\u0634\u0643\u0644 1). <\/span>\u0648\u064f\u062c\u0650\u062f\u064e \u0641\u0627\u0631\u0642\u064c \u0645\u0639\u0646\u0648\u064a\u064c \u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0639 \u0627\u0644\u0623\u062e\u0631\u0649 \u0639\u0644\u0649 \u062d\u062f\u0629 \u0623\u064a\u0636\u064b\u0627\u060c \u0623\u064a \u0644\u062f\u0649 \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0628\u064a\u0646 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0648\u0631\u0627\u062a \u0648\u0645\u0631\u0636\u0649 \u0627\u0644\u0647\u062f\u0623\u0629 p = 0.0001\u060c \u0648\u0643\u0630\u0644\u0643 \u0639\u0646\u062f \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0648\u0631\u0627\u062a \u0648\u0627\u0644\u0623\u0635\u062d\u0627\u0621 p = 0.0001 \u0648\u0644\u062f\u0649 \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 \u0648\u0627\u0644\u0623\u0635\u062d\u0627\u0621 p = 0.0001 \u0623\u064a\u0636\u064b\u0627 (\u0627\u0644\u0634\u0643\u0644 1).<\/span><\/p>\n

\u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 <\/strong>ECP<\/strong> \u0628\u064a\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0648\u0627\u0644\u0625\u0646\u0627\u062b \u0641\u064a \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649:<\/strong><\/span><\/p>\n

\u0644\u0645 \u0646\u062c\u062f \u0641\u0631\u0642\u064b\u0627 \u0645\u0639\u062a\u062f\u064b\u0627 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u064b\u0627 \u0641\u064a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0648\u0627\u0644\u0625\u0646\u0627\u062b \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 \u0648\u0643\u0630\u0644\u0643 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (\u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 \u0648\u062d\u0627\u0644\u0629 \u0627\u0644\u0633\u0648\u0631\u0629) \u0625\u0630 \u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629 P (0.524\u060c 0.583 \u06480.850) \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628.<\/span><\/p>\n

\u0627\u0631\u062a\u0628\u0627\u0637 \u062a\u0631\u0627\u0643\u064a\u0632 <\/strong>ECP<\/strong> \u0645\u0639 \u0627\u0644\u0639\u0645\u0631 \u0628\u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629:<\/strong><\/span><\/p>\n

\u0644\u0645 \u0646\u062c\u062f \u0627\u0631\u062a\u0628\u0627\u0637\u064b\u0627 \u0645\u0639\u0646\u0648\u064a\u064b\u0627 \u0628\u064a\u0646 \u0627\u0644\u0639\u0645\u0631 \u0648\u062a\u0631\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0625\u0630 \u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629 P<\/em> \u0644\u062f\u0649 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 0.459\u060c \u0648\u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 0.547\u060c \u0623\u0645\u0627 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0648\u0631\u0627\u062a \u0641\u0628\u0644\u063a\u062a 0.590.<\/span><\/p>\n

\"\u0627\u0644\u0634\u0643\u0644
\u00a0\u0627\u0644\u0634\u0643\u0644 1: \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 \u0648\u0645\u0631\u0636\u0649 COPD \u0628\u062d\u0627\u0644\u062a\u064a \u0627\u0644\u0647\u062f\u0623\u0629 \u0648\u0627\u0644\u0633\u0648\u0631\u0629<\/span><\/strong><\/span><\/figcaption><\/figure>\n

\u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 <\/strong>ECP<\/strong> \u0648\u0639\u062f\u062f \u0623\u064a\u0627\u0645 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0648\u0631\u0627\u062a:<\/strong><\/span><\/p>\n

\u0644\u0645 \u0646\u062c\u062f \u0627\u0631\u062a\u0628\u0627\u0637\u064b\u0627 \u0645\u0639\u0646\u0648\u064a\u064b\u0627 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0648\u0639\u062f\u062f \u0623\u064a\u0627\u0645 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621 P = 0.802 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0633\u0648\u0631\u0627\u062a \u0627\u0644\u0640COPD.<\/span><\/p>\n

\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0645\u0646\u0633\u0628 \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0648\u062a\u0631\u0627\u0643\u064a\u0632 <\/strong>ECP<\/strong> \u0644\u062f\u0649 \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0639\u0644\u0649 \u062d\u062f\u0629:<\/strong><\/span><\/p>\n

\u0644\u0645 \u0646\u062c\u062f \u0627\u0631\u062a\u0628\u0627\u0637\u064b\u0627 \u0645\u0639\u0646\u0648\u064a\u064b\u0627 \u0628\u064a\u0646 \u0645\u0646\u0633\u0628 \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0648\u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 \u0648\u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (\u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u062f\u0623\u0629 \u0648\u062d\u0627\u0644\u0629 \u0627\u0644\u0633\u0648\u0631\u0629) \u0625\u0630 \u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629 P<\/em> 0.183 \u06480.319 \u06480.405 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628.<\/span><\/p>\n

\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong>Discussion<\/strong><\/span><\/p>\n

\u062a\u064f\u0639\u064e\u062f \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0648\u0627\u0644\u0645\u062a\u0631\u0642\u064a\u0629 \u0641\u064a \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0627\u0644\u0633\u0645\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f\u064a \u0627\u0644\u0645\u0632\u0645\u0646 COPD\u060c \u0627\u0644\u0630\u064a \u064a\u064f\u0634\u064e\u062e\u0651\u064e\u0635 \u0639\u0644\u0649 \u0646\u062d\u0648 \u0631\u0626\u064a\u0633 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0646\u0641\u0633 Spirometry [1, 2]\u060c \u064a\u0639\u062a\u0645\u062f \u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0646\u0641\u0633 \u0639\u0644\u0649 \u062a\u0623\u0643\u064a\u062f \u0648\u062c\u0648\u062f \u062a\u062d\u062f\u062f \u0647\u0648\u0627\u0626\u064a \u0645\u0646 \u0639\u062f\u0645\u0647 \u0645\u0646 \u062f\u0648\u0646 \u0623\u0646 \u064a\u0639\u0637\u064a \u0623\u064a\u0629 \u0641\u0643\u0631\u0629 \u0639\u0646 \u0627\u0644\u0622\u0644\u064a\u0629 \u0627\u0644\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0623\u0648 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629\u060c \u0648\u062a\u0631\u0642\u064a\u0647\u0627 \u0641\u064a \u0623\u062b\u0646\u0627\u0621 \u062a\u0637\u0648\u0631 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 [12, 13]. \u0648\u0645\u0646 \u062b\u0645\u0651\u064e \u0645\u0646 \u0627\u0644\u0645\u0641\u064a\u062f \u062a\u062d\u062f\u064a\u062f \u0648\u0627\u0635\u0645\u0627\u062a \u062d\u064a\u0648\u064a\u0629 \u062a\u0642\u064a\u0651\u0645 \u0647\u0630\u0647 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0645\u0646 \u062d\u064a\u062b \u0646\u0648\u0639\u0647\u0627 \u0648\u0634\u062f\u062a\u0647\u0627 \u0648\u062a\u0631\u0642\u064a\u0647\u0627 \u0648\u0647\u0630\u0627 \u0642\u062f \u064a\u0633\u0647\u0645 \u0628\u0632\u064a\u0627\u062f\u0629 \u0641\u0647\u0645 \u0627\u0644\u0622\u0644\u064a\u0629 \u0627\u0644\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0644\u0640COPD\u060c \u0648\u0645\u0631\u0627\u0642\u0628\u0629 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0642\u062f \u064a\u062d\u0633\u0651\u0646 \u0647\u0630\u0627 \u0627\u0644\u0623\u0645\u0631 \u0645\u0646 \u062a\u062f\u0628\u064a\u0631 \u0645\u0631\u0636\u0649 \u0627\u0644\u0640COPD \u0623\u064a\u0636\u064b\u0627. <\/span>\u0648\u0645\u0639 \u0623\u0646\u0651 \u0646\u0645\u0637 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u0633\u0627\u0626\u062f \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u062f\u0627\u0621 \u0647\u0648 \u0630\u0627\u0643 \u0627\u0644\u0645\u062a\u0648\u0627\u0633\u0637 \u0628\u0627\u0644\u0639\u062f\u0644\u0627\u062a\u060c \u0641\u0642\u062f \u0623\u0634\u0627\u0631\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u062f\u0648\u0631 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0641\u064a \u0631\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0645\u0645\u064a\u0632 \u0644\u0644\u0640COPD [5-8]\u060c \u0648\u0644\u0643\u0646 \u0645\u0646 \u062f\u0648\u0646 \u0627\u0644\u062a\u0637\u0631\u0642 \u0625\u0644\u0649 \u062f\u0648\u0631 \u062a\u0641\u0639\u064a\u0644\u0647\u0627\u060c \u0648\u0645\u0627 \u064a\u0631\u0627\u0641\u0642\u0647 \u0645\u0646 \u0625\u0641\u0631\u0627\u0632 \u0645\u062d\u062a\u0648\u064a\u0627\u062a\u0647\u0627 \u0641\u064a \u0631\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0647\u0630\u0627. <\/span>\u062a\u0641\u0631\u0632 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0645\u062d\u062a\u0648\u064a\u0627\u062a \u062d\u0628\u064a\u0628\u0627\u062a\u0647\u0627 \u0639\u0642\u0628 \u062a\u0641\u0639\u064a\u0644\u0647\u0627\u060c \u0648\u0647\u062c\u0631\u062a\u0647\u0627 \u0625\u0644\u0649 \u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0648\u064a\u064f\u0639\u064e\u062f \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a \u0627\u0644\u0643\u0627\u062a\u064a\u0648\u0646\u064a ECP \u0648\u0627\u062d\u062f\u0627\u064b \u0645\u0646 \u0623\u0628\u0631\u0632 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u062d\u0628\u064a\u0628\u0627\u062a \u0627\u0644\u062d\u0645\u0636\u0627\u062a\u060c \u0648\u062a\u064f\u0639\u064e\u062f \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u0645\u0634\u0639\u0631\u064b\u0627 \u0641\u064a \u0627\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u062a\u0641\u0639\u064a\u0644\u0647\u0627\u060c \u0648\u064a\u062a\u0645\u062a\u0639 \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u0641\u0639\u0627\u0644\u064a\u0627\u062a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0633\u0627\u0645\u0629 \u0648\u063a\u064a\u0631 \u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u062a\u062c\u0639\u0644\u0647 \u0645\u062d\u0637 \u0627\u0647\u062a\u0645\u0627\u0645 \u0644\u062f\u0631\u0627\u0633\u0629 \u062f\u0648\u0631\u0647 \u0648\u062a\u0623\u062b\u064a\u0631\u0647 \u0641\u064a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0643\u0627\u0644\u0640COPD [9, 10]. <\/span>\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0627\u0631\u062a\u0641\u0627\u0639\u064b\u0627 \u0645\u0644\u062d\u0648\u0638\u064b\u0627 \u0641\u064a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 COPD \u0644\u062f\u0649 \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0623\u0635\u062d\u0627\u0621\u060c \u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062d\u062f\u0648\u062b \u062a\u0641\u0639\u064a\u0644 \u0644\u0644\u062d\u0645\u0636\u0627\u062a \u0644\u062f\u0649 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0625\u0641\u0631\u0627\u0632\u0647\u0627 \u0640ECP \u0648\u063a\u064a\u0631\u0647 \u0645\u0646 \u0645\u062d\u062a\u0648\u064a\u0627\u062a \u062d\u0628\u064a\u0628\u0627\u062a\u0647\u0627 \u0645\u062b\u0644 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0645\u062b\u0644 IL-2\u060c IL-3 \u0648\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0646\u0645\u0648 \u0645\u062b\u0644 \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u062e\u0631 \u0627\u0644\u0648\u0631\u0645\u064a tumor necrosis factor (TNF) \u0627\u0644\u062a\u064a \u062a\u062a\u062f\u0627\u062e\u0644 \u062c\u0645\u064a\u0639\u0647\u0627 \u0628\u0625\u0628\u0642\u0627\u0621 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0645\u0633\u062a\u0645\u0631\u0629 \u0641\u064a \u0627\u0644\u0631\u0626\u062a\u064a\u0646 \u0648\u0628\u0627\u0644\u0623\u0630\u064a\u0629 \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0627\u0644\u062d\u0627\u0635\u0644\u0629 [5]. \u0648\u064a\u0645\u0643\u0646 \u062a\u0641\u0633\u064a\u0631 \u062f\u0648\u0631 \u0640ECP\u00a0 \u0628\u0647\u0630\u0647 \u0627\u0644\u0623\u0630\u064a\u0629 \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0644\u0640COPD \u0628\u0648\u0633\u0627\u0637\u0629 \u0645\u0627 \u064a\u062a\u0645\u062a\u0639 \u0628\u0647 \u0645\u0646 \u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u062d\u0631\u064a\u0636 \u0627\u0644\u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0648\u064a \u0627\u0644\u0645\u0628\u0631\u0645\u062c \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 \u0641\u064a \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0628\u062a\u0641\u0639\u064a\u0644 \u0634\u0644\u0627\u0644 \u0627\u0644\u0643\u0627\u0633\u0628\u0627\u0632 Caspase cycle\u060c \u0648\u064a\u0633\u0647\u0645 \u0641\u064a \u0625\u0639\u0627\u062f\u0629 \u062a\u0634\u0643\u064a\u0644 (\u0646\u0645\u0630\u062c\u0629) \u0646\u0633\u064a\u062c \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0648\u0645\u0627 \u064a\u0631\u0627\u0641\u0642 \u0630\u0644\u0643 \u0645\u0646 \u062d\u062f\u0648\u062b \u062a\u0644\u064a\u0641 \u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0628\u0648\u0633\u0627\u0637\u0629 \u062c\u0630\u0628\u0647 \u0644\u0644\u0623\u0631\u0648\u0645\u0629 \u0627\u0644\u0644\u064a\u0641\u064a\u0629\u060c \u0648\u062a\u062d\u0631\u064a\u0636 \u0632\u064a\u0627\u062f\u0629 \u0627\u0635\u0637\u0646\u0627\u0639 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0648\u063a\u0644\u064a\u0643\u0627\u0646\u060c \u0648\u062a\u062b\u0628\u064a\u0637 \u062a\u062d\u0644\u0644\u0647 \u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0631\u0627\u0643\u0645\u0647 \u0636\u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 [9]. <\/span>\u0648\u062c\u062f \u0641\u064a\u0648\u0631\u064a\u0646\u064a \u0648\u0632\u0645\u0644\u0627\u0624\u0647 [14] \u0646\u062a\u0627\u0626\u062c \u0645\u0634\u0627\u0628\u0647\u0629 \u0645\u0646 \u062d\u064a\u062b \u0627\u0631\u062a\u0641\u0627\u0639 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 COPD \u0628\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0631\u0629 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u0644\u062f\u0649 \u0627\u0644\u0623\u0635\u062d\u0627\u0621. <\/span>\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0627\u0631\u062a\u0641\u0627\u0639\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0641\u064a \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0633\u0648\u0631\u0627\u062a \u0627\u0644\u0640COPD \u0639\u0646\u062f \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0628\u0645\u0631\u0636\u0649 \u0627\u0644\u0647\u062f\u0623\u0629 \u0623\u064a\u0636\u064b\u0627\u060c \u0623\u064a \u0627\u0632\u062f\u0627\u062f \u062a\u0641\u0639\u064a\u0644 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0641\u064a \u0623\u062b\u0646\u0627\u0621 \u0633\u0648\u0631\u0627\u062a \u0627\u0644\u0645\u0631\u0636 \u0636\u0645\u0646 \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0648\u0630\u0644\u0643 \u064a\u062a\u0631\u0627\u0641\u0642 \u0645\u0639 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0636\u0645\u0646\u0647\u0627\u060c \u0648\u0623\u0628\u0631\u0632\u0647\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a \u0627\u0644\u0643\u0627\u062a\u064a\u0648\u0646\u064a \u0630\u0648 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 [11]\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u062d\u0637\u0645 \u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629\u060c \u0648\u064a\u0632\u064a\u062f \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0645\u062e\u0627\u0637 [15] \u0648\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0642\u0644\u0635 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0645\u0644\u0633 \u0641\u064a \u0627\u0644\u0633\u0628\u0644 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 [16]\u060c \u0623\u064a \u064a\u0633\u0647\u0645 \u0628\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0647\u0630\u0647 \u0627\u0644\u0633\u0648\u0631\u0627\u062a\u060c \u0648\u0623\u0639\u0631\u0627\u0636\u0647\u0627 \u0627\u0644\u0645\u0631\u0627\u0641\u0642\u0629 \u0645\u062b\u0644 \u0632\u064a\u0627\u062f\u0629 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0628\u0644\u063a\u0645 \u0648\u0634\u062f\u0629 \u0627\u0644\u0632\u0644\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 [1]. \u0648\u064f\u062c\u0650\u062f\u064e\u062a \u0646\u062a\u0627\u0626\u062c \u0645\u0645\u0627\u062b\u0644\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0639\u062b\u0645\u0627\u0646 \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0641\u064a \u0645\u0635\u0631 \u0627\u0644\u062a\u064a \u0623\u0634\u0627\u0631\u062a \u0625\u0644\u0649 \u062f\u0648\u0631 ECP \u0641\u064a \u062d\u062f\u0648\u062b \u0633\u0648\u0631\u0627\u062a COPD [17]\u060c \u0648\u0643\u0630\u0644\u0643 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u064a\u0627\u0646\u063a \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0641\u064a \u0627\u0644\u0635\u064a\u0646 [11] \u0627\u0644\u0630\u064a\u0646 \u062f\u0631\u0633\u0648\u0627 \u062f\u0648\u0631 \u062a\u0641\u0639\u064a\u0644 \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0641\u064a \u062d\u062f\u0648\u062b \u0633\u0648\u0631\u0627\u062a COPD \u0628\u0648\u0633\u0627\u0637\u0629 \u0645\u0639\u0627\u064a\u0631\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u062d\u0628\u064a\u0628\u0627\u062a \u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0644\u062f\u0649 \u062a\u0641\u0639\u064a\u0644\u0647\u0627 \u0648\u0647\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0627\u0644\u0642\u0627\u0639\u062f\u064a\u060c \u0648\u0627\u0644\u0628\u0631\u0648\u0643\u0633\u064a\u062f\u0627\u0632 \u0627\u0644\u0627\u064a\u0648\u0632\u064a\u0646\u064a\u060c \u0648\u0627\u0644\u0633\u0645 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0634\u062a\u0642 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636\u0627\u062a. <\/span>\u062a\u064f\u0639\u064e\u062f \u0633\u0648\u0631\u0627\u062a \u0627\u0644\u0640COPD \u0623\u062d\u062f \u0623\u0628\u0631\u0632 \u0627\u0644\u0623\u0633\u0628\u0627\u0628 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0639\u0628\u0621 \u0627\u0644\u0627\u0642\u062a\u0635\u0627\u062f\u064a \u0627\u0644\u0643\u0628\u064a\u0631 \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0643\u0630\u0644\u0643 \u0627\u0644\u0633\u0628\u0628 \u0627\u0644\u0631\u0626\u064a\u0633 \u0644\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621 \u0644\u062f\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647 [1]\u060c \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0641\u064a\u062f \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0637\u0648\u0644 \u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621 \u0644\u062f\u0649 \u0643\u0644 \u0645\u0631\u064a\u0636 \u0628\u0627\u062a\u062e\u0627\u0630 \u062a\u062f\u0627\u0628\u064a\u0631 \u0639\u0644\u0627\u062c\u064a\u0629 \u062a\u0633\u0647\u0645 \u0641\u064a \u062a\u0642\u0644\u064a\u0644 \u0647\u0630\u0647 \u0627\u0644\u0645\u062f\u0629\u060c \u0648\u0644\u0645 \u062a\u0638\u0647\u0631 \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0648\u062c\u0648\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u0645\u0627 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0648\u0637\u0648\u0644 \u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0648\u0631\u0627\u062a\u060c \u0648\u0645\u0646 \u062b\u0645\u0651\u064e \u064a\u0633\u0647\u0645 \u0627\u0644\u0640ECP \u0628\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0648\u062d\u062f\u0648\u062b \u0633\u0648\u0631\u0627\u062a \u0627\u0644\u0640COPD \u0648\u0644\u0643\u0646 \u0644\u0627 \u064a\u0645\u0643\u0646 \u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u0641\u064a \u0627\u0644\u062a\u0646\u0628\u0624 \u0628\u0637\u0648\u0644 \u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621.<\/span><\/p>\n

\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong><\/span><\/p>\n

\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0627\u0631\u062a\u0641\u0627\u0639 \u062a\u0631\u0627\u0643\u064a\u0632 ECP \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 COPD\u060c \u0648\u062a\u0631\u0627\u0641\u0642\u062a \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u0627\u0644\u0623\u0634\u062f \u0627\u0631\u062a\u0641\u0627\u0639\u064b\u0627 \u0645\u0639 \u0637\u0648\u0631 \u0633\u0648\u0631\u0629 \u0627\u0644\u0640COPD\u060c \u0645\u0627 \u064a\u062c\u0639\u0644 \u0645\u0646 ECP \u0648\u0627\u0635\u0645\u064b\u0627 \u062d\u064a\u0648\u064a\u064b\u0627 \u0645\u062d\u062a\u0645\u0644\u064b\u0627 \u0641\u064a \u0627\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u0634\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0627\u0633\u0637\u0629 \u0628\u0627\u0644\u062d\u0645\u0636\u0627\u062a \u0648\u062a\u0631\u0642\u064a\u0647\u0627 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 CPOPD. \u0644\u0645 \u062a\u064f\u0638\u0647\u0650\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u064a \u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0640ECP \u0648\u0639\u0645\u0631 \u0627\u0644\u0645\u0631\u064a\u0636 \u0623\u0648 \u062c\u0646\u0633\u0647 \u0623\u0648 \u0645\u0646\u0633\u0628 \u0627\u0644\u062a\u062f\u062e\u064a\u0646\u060c \u0648\u0644\u0645 \u062a\u064f\u0638\u0647\u0650\u0631 \u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632\u0647\u060c \u0648\u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u0634\u0641\u0627\u0621 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0648\u0631\u0627\u062a.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u064a\u064f\u0639\u0631\u0651\u064e\u0641 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f\u064a \u0627\u0644\u0645\u0632\u0645\u0646 \u0623\u0646\u0647 \u0645\u0631\u0636\u064c \u0634\u0627\u0626\u0639 \u064a\u0645\u0643\u0646 \u062a\u062f\u0628\u064a\u0631\u0647 \u0648\u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646\u0647\u060c \u064a\u062a\u0631\u0627\u0641\u0642 \u0645\u0639 \u0623\u0639\u0631\u0627\u0636 \u062a\u0646\u0641\u0633\u064a\u0629 \u062f\u0627\u0626\u0645\u0629 \u0623\u0628\u0631\u0632\u0647\u0627 \u0627\u0644\u0632\u0644\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629…
\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":190,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-146","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-135","volume-9"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=146"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/146\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/190"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}