{"id":153,"date":"2023-07-01T11:41:08","date_gmt":"2023-07-01T11:41:08","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=153"},"modified":"2024-12-24T18:36:58","modified_gmt":"2024-12-24T18:36:58","slug":"%d8%aa%d9%88%d8%a7%d8%aa%d8%b1-%d8%a7%d9%84%d8%a3%d9%84%d9%8a%d9%84-%d9%86%d8%a7%d9%82%d8%b5-%d8%a7%d9%84%d9%88%d8%b8%d9%8a%d9%81%d8%a9-cyp2d610-%d9%88%d8%aa%d8%ad%d8%b1%d9%91%d9%8a-%d8%aa%d8%a3","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=153","title":{"rendered":"\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 \u0646\u0627\u0642\u0635 \u0627\u0644\u0648\u0638\u064a\u0641\u0629 CYP2D6*10 \u0648\u062a\u062d\u0631\u0651\u064a \u062a\u0623\u062b\u064a\u0631\u0647 \u0641\u064a \u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0628\u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0633\u0648\u0631\u064a\u0651\u0627\u062a"},"content":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction<\/span><\/strong><\/p>\n

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\u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u0641\u064a\u0646 \u0628\u0623\u0646\u0651\u0647 \u0637\u0644\u064a\u0639\u0629 \u062f\u0648\u0627\u0621 prodrug \u0636\u0639\u064a\u0641 \u0627\u0644\u0623\u0644\u0641\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0648\u064a\u062a\u0637\u0644\u0651\u0628 \u062a\u0641\u0639\u064a\u0644\u0627\u064b \u062d\u064a\u0648\u064a\u0651\u0627\u064b \u0628\u062a\u0648\u0627\u0633\u0637 \u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u0631\u0648\u0645 cytochrome P450 \u0641\u064a \u0627\u0644\u0643\u0628\u062f \u0625\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0628\u0627\u062a \u0627\u0644\u0623\u0643\u062b\u0631 \u0641\u0639\u0627\u0644\u064a\u0651\u0629\u060c \u0648\u0623\u0647\u0645\u0651\u0647\u0627\u00a0 4-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u00a04-hydroxytamoxifen (4HT) \u06484-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0645\u0646\u0632\u0648\u0639 \u0627\u0644\u0645\u064a\u062a\u064a\u0644 hydroxy-N-desmethyltamoxifen \u00a04-\u0623\u0648 \u0645\u0627 \u064a\u064f\u0639\u0631\u0641 \u0628\u0627\u0644\u0625\u0646\u062f\u0648\u0643\u0633\u064a\u0641\u064a\u0646 endoxifen\u060c \u0648\u0647\u0630\u0627\u0646 \u0627\u0644\u0645\u0631\u0643\u0651\u0628\u0627\u0646 \u064a\u0645\u062a\u0644\u0643\u0627\u0646 \u0623\u0644\u0641\u0629 \u062a\u062c\u0627\u0647 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u062a\u0641\u0648\u0642 \u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0628\u0640 100 \u0636\u0639\u0641\u064d\u060c \u0648\u062a\u0641\u0648\u0642 \u0641\u0639\u0627\u0644\u064a\u0651\u062a\u0647\u0645\u0627 \u0641\u064a \u0643\u0628\u062d \u062a\u0643\u0627\u062b\u0631 \u062e\u0644\u0627\u064a\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0639\u0644\u0649 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u0641\u064a\u0646 \u0628\u0640 30 \u0625\u0644\u0649 100 \u0636\u0639\u0641. \u064a\u062a\u0643\u0627\u0641\u0623 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0628\u0627\u0646 4HT \u0648\u0627\u0644\u0625\u0646\u062f\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0641\u064a \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0651\u0629\u060c \u0644\u0643\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0625\u0646\u062f\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u064a\u0651\u0629 \u062a\u0641\u0648\u0642 \u062a\u0644\u0643 \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u06404HT \u0628\u06405 \u0625\u0644\u0649 10 \u0623\u0636\u0639\u0627\u0641\u060c \u0644\u0630\u0644\u0643 \u062a\u0639\u0632\u0649 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0648\u0627\u0644\u0623\u0647\u0645\u064a\u0651\u0629 \u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0651\u0629 \u0628\u0635\u0648\u0631\u0629\u064d \u0631\u0626\u064a\u0633\u064a\u0651\u0629 \u0644\u0644\u0625\u0646\u062f\u0648\u0643\u0633\u064a\u0641\u064a\u0646 (Binkhorst et al.<\/em>, 2015; Wigle et al.<\/em>, 2017). <\/span>\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0634\u062a\u0631\u0627\u0643 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0627\u0644\u0633\u0651\u064a\u062a\u0648\u0643\u0631\u0648\u0645 \u0627\u0644\u0643\u0628\u062f\u064a\u0651\u0629 \u0641\u064a \u0639\u0645\u0644\u064a\u0651\u0629 \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u0641\u064a\u0646\u060c \u064a\u064f\u0639\u062f\u0651 \u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0627\u0644\u0623\u0647\u0645\u0651 \u0641\u064a \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0643\u0648\u0646\u0647 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0645\u0641\u062a\u0627\u062d\u064a\u0651 \u0641\u064a \u0627\u0644\u062a\u0651\u0641\u0639\u064a\u0644 \u0627\u0644\u062d\u064a\u0648\u064a \u0644\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u0646 \u0648\u062a\u0634\u0643\u0651\u0644 \u0627\u0644\u0625\u0646\u062f\u0648\u0643\u0633\u064a\u0641\u064a\u0646. \u062a\u0642\u0639 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0651\u0632\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0639\u0644\u0649 \u0627\u0644\u0630\u0651\u0631\u0627\u0639 \u0627\u0644\u0637\u0651\u0648\u064a\u0644 (q) \u0644\u0644\u0635\u0651\u0628\u063a\u064a 22 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 13.1 (22q13.1) \u0648\u064a\u062c\u0627\u0648\u0631\u0647 \u062c\u064a\u0646\u0627\u0646 \u0643\u0627\u0630\u0628\u0627\u0646 pseudogenes \u063a\u064a\u0631 \u0648\u0638\u064a\u0641\u064a\u064a\u0646 \u0647\u0645\u0627 CYP2D7<\/em> \u0648CYP2D8<\/em> .(Ingelman-Sundberg, 2005) \u064a\u064f\u0624\u062f\u0651\u064a \u0627\u0644\u062a\u0651\u0634\u0627\u0628\u0647 \u0627\u0644\u0643\u0628\u064a\u0631 \u0641\u064a \u0627\u0644\u062a\u0651\u0633\u0644\u0633\u0644 \u0627\u0644\u0646\u0651\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u064a \u0644\u0647\u0630\u064a\u0646 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u0627\u0644\u0643\u0627\u0630\u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0627\u0648\u0631\u064a\u0646 \u0644\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0651\u0632\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0651\u0629 \u062d\u062f\u0648\u062b \u062d\u0630\u0648\u0641\u0627\u062a \u0623\u0648 \u0625\u0636\u0627\u0641\u0627\u062a \u0623\u0648 \u0627\u0633\u062a\u0628\u062f\u0627\u0644\u0627\u062a \u0644\u0644\u0646\u0651\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0623\u0648 \u0625\u0639\u0627\u062f\u0629 \u062a\u0631\u062a\u064a\u0628 \u0623\u0648 \u062d\u0630\u0641 \u0623\u0648 \u062a\u0636\u0627\u0639\u0641 \u0627\u0644\u062c\u064a\u0646 \u0628\u0623\u0643\u0645\u0644\u0647\u0627 \u0645\u0645\u0627 \u064a\u064f\u0624\u062f\u0651\u064a \u0625\u0644\u0649 \u062a\u0634\u0643\u0651\u0644 \u0623\u0644\u0627\u0626\u0644 \u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 (Gaedigk, 2013) CYP2D6\u060c \u0644\u0630\u0644\u0643 \u064a\u064f\u0639\u062f\u0651 \u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0634\u062f\u064a\u062f \u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u062d\u064a\u062b \u062a\u0645\u0651 \u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u0623\u0643\u062b\u0631 \u0645\u0646 140 \u062a\u0639\u062f\u0651\u062f \u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u0651\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062fSingle nucleotide polymorphisms \u00a0(SNPs) \u062d\u062a\u0649 \u0627\u0644\u0622\u0646 (Gaedigk, 2022). \u062a\u064f\u0635\u0646\u0651\u0641 \u0647\u0630\u0647 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u062d\u0633\u0628 \u0641\u0639\u0627\u0644\u064a\u0651\u062a\u0647\u0627 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0651\u0629\u060c \u0641\u0625\u0645\u0651\u0627 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0637\u0628\u064a\u0639\u064a\u0651\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0651\u0629 (\u0645\u062b\u0644 CYP2D6*1<\/em> \u0648*2<\/em>) \u0623\u0648 \u0645\u0646\u0642\u0648\u0635\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0651\u0629 (\u0645\u062b\u0644 CYP2D6*9<\/em> \u0648*10<\/em> \u0648*17<\/em> \u0648*41<\/em>) \u0623\u0648 \u0639\u062f\u064a\u0645\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0651\u0629 (\u0645\u062b\u0644 CYP2D6*3<\/em> \u0648*4<\/em> \u0648*5<\/em>) \u0623\u0648 \u0641\u0627\u0626\u0642\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0651\u0629 \u0646\u062a\u064a\u062c\u0629 \u062a\u0636\u0627\u0639\u0641 \u0639\u062f\u062f \u0627\u0644\u0646\u0651\u0633\u062e (\u0645\u062b\u0644 *1xN<\/em>\u0648<\/em> *2xN<\/em>\u0648*35xN<\/em>). \u064a\u064f\u062a\u0631\u062c\u0645 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0628\u0639\u062f\u0647\u0627 \u0625\u0644\u0649 \u0623\u0631\u0628\u0639\u0629 \u0623\u0646\u0645\u0627\u0637 \u0638\u0627\u0647\u0631\u064a\u0651\u0629 \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0634\u0641\u0639 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0627\u0644\u062a\u064a \u064a\u0645\u062a\u0644\u0643\u0647\u0627 \u0643\u0644 \u0641\u0631\u062f \u0641\u064a \u062a\u0631\u0643\u064a\u0628\u062a\u0647 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0627\u0644\u0641\u0631\u062f \u0636\u0639\u064a\u0641 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 poor metabolizer (PM) \u0623\u0648 \u0645\u062a\u0648\u0633\u0651\u0637 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 intermediate metabolizer (IM) \u0623\u0648 \u0637\u0628\u064a\u0639\u064a \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 normal metabolizer (NM) \u0623\u0648 \u0641\u0627\u0626\u0642 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 ultrarapid metabolizer (UM)(Goetz et al.<\/em>, 2018). <\/span>\u064a\u064f\u0639\u062f\u0651 \u0627\u0644\u0627\u0644\u064a\u0644 \u00a0CYP2D6*10<\/em>\u0623\u062d\u062f \u0623\u0647\u0645\u0651 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0646\u0627\u0642\u0635\u0629 \u0627\u0644\u0648\u0638\u064a\u0641\u0629\u060c \u0648\u064a\u0646\u062a\u062c \u0639\u0646 \u0637\u0641\u0631\u0629 \u0646\u0642\u0637\u064a\u0651\u0629 (100C>T) \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 1 \u062d\u064a\u062b \u064a\u062d\u0644 \u0627\u0644\u062b\u0627\u064a\u0645\u064a\u0646 \u0645\u062d\u0644 \u0627\u0644\u0633\u064a\u062a\u0648\u0632\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 100 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u062d\u0644\u0651 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a \u0627\u0644\u0633\u0651\u064a\u0631\u064a\u0646 \u0645\u062d\u0644 \u0627\u0644\u0628\u0631\u0648\u0644\u064a\u0646\u060c \u0648\u064a\u0646\u062a\u062c \u0639\u0646 \u0630\u0644\u0643 \u0625\u0646\u0632\u064a\u0645 \u063a\u064a\u0631 \u062b\u0627\u0628\u062a \u0628\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0636\u0639\u064a\u0641\u0629 \u0648\u0623\u0644\u0641\u0629 \u0645\u0646\u062e\u0641\u0636\u0629 \u062a\u062c\u0627\u0647 \u0627\u0644\u0631\u0651\u0643\u0627\u0632\u0627\u062a (Ingelman-Sundberg, 2005). <\/span>\u0639\u0644\u0649 \u0627\u0644\u0631\u0651\u063a\u0645 \u0645\u0646 \u0627\u0644\u062f\u0651\u0648\u0631 \u0627\u0644\u0628\u0627\u0644\u063a \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0641\u064a \u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646\u060c \u0644\u0627\u062a\u0632\u0627\u0644 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0644\u0623\u0644\u064a\u0644 \u0646\u0627\u0642\u0635 \u0627\u0644\u0648\u0638\u064a\u0641\u0629 CYP2D*10<\/em> \u0641\u064a \u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u063a\u064a\u0631 \u0648\u0627\u0636\u062d\u0629 \u0646\u062a\u064a\u062c\u0629 \u0644\u0644\u062a\u0651\u0646\u0627\u0642\u0636 \u0627\u0644\u0643\u0628\u064a\u0631 \u0641\u064a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0627\u062a. \u0648\u0641\u064a \u0638\u0644 \u063a\u064a\u0627\u0628 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u062d\u0648\u0644 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 CYP2D6*10<\/em> \u0644\u062f\u0649 \u0627\u0644\u0633\u0651\u0648\u0631\u064a\u0651\u064a\u0646 \u0628\u0627\u0644\u0631\u0651\u063a\u0645 \u0645\u0646 \u0627\u0646\u062a\u0634\u0627\u0631\u0647 \u0627\u0644\u0648\u0627\u0633\u0639 \u0639\u0646\u062f \u0627\u0644\u0622\u0633\u064a\u0648\u064a\u064a\u0651\u0646 \u0648\u0634\u0639\u0648\u0628 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\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong>Materials and <\/strong>Methods<\/strong><\/span><\/p>\n

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\u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 <\/strong>\u0627\u0644\u062c\u064a\u0646\u064a\u0651<\/strong>G<\/strong>enotyping <\/strong>\u00a0\u0648\u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u0627\u0644\u0623\u0644\u064a\u0644<\/strong> CYP2D6*10<\/em><\/strong><\/span><\/p>\n

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\u062a\u062e\u062b\u0631 EDTA \u0648\u062d\u0641\u0638\u062a \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 (-20o<\/sup>C) \u0625\u0644\u0649 \u062d\u064a\u0646 \u0625\u062c\u0631\u0627\u0621 \u0639\u0632\u0644 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u0645\u062c\u064a\u0646\u064a\u0651 gDNA. \u0627\u0633\u062a\u064f\u062e\u0644\u0635 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u0645\u062c\u064a\u0646\u064a\u0651 \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u062a\u064a\u062f\u0629 Wizard\u00ae Genomic DNA Purification Kit \u0645\u0646 \u0634\u0631\u0643\u0629 Promega \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u062a\u0651\u0639\u0644\u064a\u0645\u0627\u062a \u0627\u0644\u0645\u0631\u0641\u0642\u0629 \u0645\u0639 \u0627\u0644\u0639\u062a\u064a\u062f\u0629. \u062d\u064f\u062f\u0651\u062f \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0628\u0633\u0644\u0633\u0644\u0629 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0636\u062e\u064a\u0645 \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 100C>T \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 1 \u0645\u0646 \u062c\u064a\u0646 CYP2D6<\/em> \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u062a\u0651\u0633\u0644\u0633\u0644\u064apolymerase chain reaction \u00a0(PCR) \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u062a\u0651\u0627\u0644\u064a\u0629: \u062d\u064f\u0636\u0651\u0631 \u0645\u0632\u064a\u062c \u0627\u0644\u062a\u0651\u0641\u0627\u0639\u0644 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062d\u062c\u0645 \u0645\u0646\u0627\u0633\u0628 \u0645\u0646 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u0645\u0639\u0632\u0648\u0644 \u06480.5 \u0645\u064a\u0643\u0631\u0648\u0644\u062a\u0631 \u064a\u0643\u0627\u0641\u0626 \u062a\u0631\u0643\u064a\u0632 10 \u0628\u064a\u0643\u0648\u0645\u0648\u0644\/\u0645\u0643\u0644 \u0645\u0646 \u0643\u0644\u0651 \u0645\u0646 \u0627\u0644\u0645\u0634\u0631\u0651\u0639 \u0627\u0644\u062a\u0651\u0642\u062f\u0645\u064a forward primer \u0630\u064a \u0627\u0644\u062a\u0633\u0644\u0633\u0644 (5\u2019-CCATTTGGTAGTGAGGCAGGTAT-3\u2019) \u0648\u0627\u0644\u0645\u0634\u0631\u0651\u0639 \u0627\u0644\u0639\u0643\u0633\u064a\u0651 reverse primer \u0630\u064a \u0627\u0644\u062a\u0633\u0644\u0633\u0644 (5\u2019- CACCATCCATGTTTGCTTCTGGT-3\u2019) \u064810 \u0645\u0643\u0631\u0648\u0644\u062a\u0631 \u0645\u0646 \u0645\u0632\u064a\u062c \u0627\u0644\u062a\u0651\u0641\u0627\u0639\u0644 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0651 \u0645\u0633\u0628\u0642 \u0627\u0644\u062a\u0651\u062d\u0636\u064a\u0631 OnePCR\u2122 (GeneDirex\u00ae) \u0648\u0623\u064f\u0643\u0645\u0644 \u062d\u062c\u0645 \u0627\u0644\u062a\u0651\u0641\u0627\u0639\u0644 \u0627\u0644\u0646\u0651\u0647\u0627\u0626\u064a\u0651 \u0625\u0644\u0649 20 \u0645\u064a\u0643\u0631\u0648\u0644\u062a\u0631 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0646\u0642\u0651\u0649 \u0627\u0644\u062e\u0627\u0644\u064a \u0645\u0646 \u0627\u0644\u0646\u0651\u0648\u0643\u0644\u064a\u0627\u0632 nuclease-free water. \u0636\u064f\u0628\u0637\u062a \u0634\u0631\u0648\u0637 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u062f\u0648\u0651\u0631 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0651 \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0634\u0651\u0631\u0648\u0637 \u0627\u0644\u0648\u0627\u0631\u062f\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Xu \u0648\u0632\u0645\u0644\u0627\u0626\u0647 (2008) \u0645\u0639 \u0625\u062c\u0631\u0627\u0621 \u0628\u0639\u0636 \u0627\u0644\u062a\u0651\u0639\u062f\u064a\u0644\u0627\u062a \u0645\u0646 \u0623\u062c\u0644 \u0623\u0645\u062b\u0644\u0629 \u0627\u0644\u0634\u0651\u0631\u0648\u0637 \u0643\u0645\u0627 \u0647\u0648 \u0645\u064f\u0648\u0636\u0651\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (1)(Xu et al.<\/em>, 2008). \u0631\u064f\u062d\u0651\u0644\u062a \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u062a\u0651\u0641\u0627\u0639\u0644 \u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0651\u0627\u064b \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0623\u063a\u0627\u0631\u0648\u0632 \u0628\u062a\u0631\u0643\u064a\u0632 1.5% \u0645\u0648\u0633\u0648\u0645\u0629 \u0628\u0628\u0631\u0648\u0645\u064a\u062f \u0627\u0644\u0625\u064a\u062b\u064a\u062f\u064a\u0648\u0645 \u0648\u0639\u064f\u0631\u0651\u0636\u062a \u0627\u0644\u0647\u0644\u0627\u0645\u0629 \u0628\u0639\u062f \u0630\u0644\u0643 \u0644\u0644\u0623\u0634\u0639\u0651\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0651\u0629 \u0644\u0625\u0638\u0647\u0627\u0631 \u0627\u0644\u0639\u0635\u0627\u0628\u0627\u062a \u062d\u064a\u062b \u064a\u062f\u0644\u0651 \u0648\u062c\u0648\u062f \u0645\u0646\u062a\u062c \u0648\u062d\u064a\u062f \u0628\u0637\u0648\u0644 271 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 (bp) \u0639\u0644\u0649 \u0646\u062c\u0627\u062d \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0640PCR . \u0623\u064f\u0631\u0633\u0644\u062a \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u062a\u0651\u0641\u0627\u0639\u0644 \u0625\u0644\u0649 \u0634\u0631\u0643\u0629 Macrogen \u0641\u064a \u0645\u062f\u064a\u0646\u0629 \u0633\u064a\u0624\u0648\u0644-\u0643\u0648\u0631\u064a\u0627 \u0627\u0644\u062c\u0646\u0648\u0628\u064a\u0651\u0629 \u062d\u064a\u0640\u062b \u0623\u064f\u062c\u0640\u0631\u064a \u062a\u0641\u0627\u0639\u0640\u0644 \u0627\u0644\u0633\u0651\u0644\u0633\u0640\u0644\u0629 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a\u0651 \u0628\u0637\u0631\u064a\u0642\u0629 \u0633\u064a\u0646\u062c\u0631 Sanger Sequencing \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0645\u0634\u0631\u0651\u0639 \u0627\u0644\u062a\u0651\u0641\u062f\u0645\u064a\u0651 \u0648\u062c\u0647\u0627\u0632 ABI PRISM\u00ae<\/sup> 3730XL DNA Analyzer \u0648\u0639\u062a\u064a\u062f\u0629 \u0627\u0644\u0633\u0651\u0644\u0633\u0644\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 ABI PRISM\u00ae<\/sup> BigDyeTM<\/sup> \u0628\u0639\u062f \u062a\u0646\u0642\u064a\u0629 \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u062a\u0651\u0641\u0627\u0639\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0625\u0646\u0632\u064a\u0645 EnzSAP\u2122\u060c \u0648\u0645\u0646 \u062b\u0645\u0651 \u0642\u0645\u0646\u0627 \u0628\u0642\u0631\u0627\u0621\u0629 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0633\u0651\u0644\u0633\u0644\u0629 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0628\u0631\u0645\u062c\u064a\u0651\u0629 Chromas.<\/span><\/p>\n

\u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0648\u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 <\/strong>End point and statistical analyses<\/strong><\/span><\/p>\n

\u0627\u0633\u062a\u064f\u0639\u0645\u0644 \u0627\u062e\u062a\u0628\u0627\u0631 Independent Samples T test \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0645\u062a\u0648\u0633\u0651\u0637\u0627\u062a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0643\u0645\u064a\u0651\u0629 \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0651\u0629 \u0648\u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0644\u0644\u062a\u0651\u0631\u0628\u064a\u0639 Chi-square \u0648\u0641\u064a\u0634\u0631Fisher’s exact test \u00a0\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0628\u064a\u0646 \u0630\u0631\u0627\u0639\u064a\u0651 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0628\u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0644\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0641\u0626\u0648\u064a\u0651\u0629 \u0648\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646. \u0627\u0639\u062a\u064f\u0645\u062f\u062a \u0645\u0646\u062d\u0646\u064a\u0627\u062a \u0643\u0627\u0628\u0644\u0627\u0646-\u0645\u0627\u064a\u0631 Kaplan\u2013Meier \u0648\u0627\u062e\u062a\u0628\u0627\u0631 Log rank \u0644\u062d\u0633\u0627\u0628 \u0648\u0633\u064a\u0637 \u0648\u0646\u0633\u0628 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636Disease Free Survival \u00a0(DFS) \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629. \u0627\u0639\u062a\u064f\u0645\u062f\u062a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636 \u0643\u0646\u0642\u0637\u0629 \u0646\u0647\u0627\u064a\u0629 end point \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0648\u0639\u064f\u0631\u0651\u0641\u062a \u0628\u0623\u0646\u0651\u0647\u0627 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0651\u0629 \u0645\u0646 \u0628\u062f\u0621 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0628\u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u062d\u062a\u0649 \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0651\u0643\u0633 (\u0633\u0648\u0627\u0621\u064b \u0643\u0627\u0646 \u0645\u0648\u0636\u0639\u064a\u0651\u0627\u064b \u0623\u0648 \u0646\u0627\u062d\u064a\u0651\u0627\u064b \u0623\u0648 \u0646\u0642\u0627\u0626\u0644\u064a\u0651\u0627\u064b) \u0623\u0648 \u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0622\u062e\u0631 \u0623\u0648 \u0627\u0644\u0648\u0641\u0627\u0629 \u0644\u0623\u064a\u0651 \u0633\u0628\u0628 \u0643\u0627\u0646. \u0627\u0633\u062a\u064f\u0639\u0645\u0644 \u0646\u0645\u0648\u0630\u062c \u0643\u0648\u0643\u0633 \u0644\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0646\u0633\u0628\u064a\u0651\u0629 Cox proportional hazards \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0630\u0627\u062a \u0627\u0644\u0623\u0647\u0645\u064a\u0651\u0629 \u0648\u0627\u062e\u062a\u0628\u0627\u0631 \u0623\u064a\u0651\u0629 \u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0645\u0633\u062a\u0642\u0644\u0651\u0629 \u0644\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0641\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0651\u0643\u0633. \u0627\u0639\u062a\u064f\u0645\u062f\u062a \u0642\u064a\u0645\u0629 P<0.05 \u0642\u064a\u0645\u0629\u064b \u0645\u0639\u062a\u062f\u0627\u064b \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0648\u0623\u062c\u0631\u064a\u062a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0628\u0631\u0645\u062c\u064a\u0651\u0629 SPSS \u0628\u0625\u0635\u062f\u0627\u0631\u0647 \u0627\u0644\u062e\u0627\u0645\u0633 \u0648\u0627\u0644\u0639\u0634\u0631\u064a\u0646 \u0648GraphPad Prism \u0628\u0625\u0635\u062f\u0627\u0631\u0647 \u0627\u0644\u062a\u0627\u0633\u0639.<\/span><\/p>\n\n\n\n\n\n\n\n
\u0627\u0644\u062c\u062f\u0648\u0644 (1): \u0634\u0631\u0648\u0637 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0640<\/strong>PCR <\/strong>\u00a0\u0644\u062a\u0636\u062e\u064a\u0645 \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 <\/strong>100C>T<\/strong><\/span><\/td>\n<\/tr>\n
\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u062a\u0651\u0641\u0627\u0639\u0644<\/strong><\/span><\/td>\n\u0627\u0644\u062a\u0651\u0645\u0633\u0651\u062e \u0627\u0644\u0628\u062f\u0626\u064a\u0651<\/strong><\/span><\/p>\n

Initial denaturation<\/strong><\/span><\/td>\n

\u0627\u0644\u062a\u0651\u0645\u0633\u0651\u062e<\/strong><\/span><\/p>\n

Denaturation<\/strong><\/span><\/td>\n

\u0627\u0644\u062a\u0651\u0644\u062f\u064a\u0646<\/strong><\/span><\/p>\n

Annealing<\/strong><\/span><\/td>\n

\u0627\u0644\u0627\u0633\u062a\u0637\u0627\u0644\u0629<\/strong><\/span><\/p>\n

Elongation<\/strong><\/span><\/td>\n

\u0627\u0644\u0627\u0633\u062a\u0637\u0627\u0644\u0629 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0651\u0629<\/strong><\/span><\/p>\n

Final elongation<\/strong><\/span><\/td>\n<\/tr>\n

\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629<\/span><\/td>\n94o<\/sup>C<\/span><\/td>\n94o<\/sup>C<\/span><\/td>\n60o<\/sup>C<\/span><\/td>\n72o<\/sup>C<\/span><\/td>\n72o<\/sup>C<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0645\u062f\u0651\u0629<\/span><\/td>\n15 \u062f\u0642\u064a\u0642\u0629<\/span><\/td>\n30 \u062b\u0627\u0646\u064a\u0629<\/span><\/td>\n45 \u062b\u0627\u0646\u064a\u0629<\/span><\/td>\n45 \u062b\u0627\u0646\u064a\u0629<\/span><\/td>\n10 \u062f\u0642\u0627\u0626\u0642<\/span><\/td>\n<\/tr>\n
\u0639\u062f\u062f \u0627\u0644\u062f\u0651\u0648\u0631\u0627\u062a<\/span><\/td>\n<\/td>\n35 \u062f\u0648\u0631\u0629<\/span><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0627\u0644\u0646\u0651\u062a\u0627\u0626\u062c<\/strong>Results <\/strong><\/span><\/p>\n

\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0648\u0633\u0645\u0627\u062a \u0627\u0644\u0648\u0631\u0645<\/strong><\/span><\/p>\n

\u062d\u0642\u0651\u0642\u062a 103 \u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0651\u0636\u0645\u064a\u0646 \u0648\u062a\u0648\u0632\u0651\u0639\u0646 \u0628\u064a\u0646 \u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 (n=61) \u0648\u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f (n=42). \u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0639\u0645\u0631 \u0644\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0627\u062a \u0641\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0639\u0646\u062f \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u0631\u0636 48.88 \u00b1 8.98 \u0639\u0627\u0645\u0627\u064b. \u0643\u0627\u0646\u062a \u062d\u0648\u0627\u0644\u064a \u0646\u0635\u0641 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062an=53 \u00a0(51.5%) \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u0627 \u0628\u0639\u062f \u0633\u0646\u0651 \u0627\u0644\u0625\u064a\u0651\u0627\u0633 \u0648\u0645\u0639\u0638\u0645\u0647\u0646\u0651n=83 \u00a0(%80.6) \u0645\u0646 \u063a\u064a\u0631 \u0627\u0644\u0645\u062f\u062e\u0651\u0646\u0627\u062a \u0641\u064a\u0645\u0627 \u0623\u0628\u0644\u063a\u062a 28 \u0645\u0631\u064a\u0636\u0629 (27.2%) \u0639\u0646 \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a\u0651 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0644\u062f\u0649 \u0642\u0631\u064a\u0628\u0627\u062a \u0645\u0646 \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0627\u0644\u062b\u0651\u0627\u0646\u064a\u0629. \u0639\u0627\u0646\u062a \u0642\u0631\u0627\u0628\u0629 \u0646\u0635\u0641 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062an=50 \u00a0(48.5%) \u0645\u0646 \u0648\u0631\u0645 \u0645\u0646 \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0627\u0644\u062b\u0651\u0627\u0646\u064a\u0629 \u0648\u062a\u0631\u0627\u0648\u062d \u062d\u062c\u0645 \u0627\u0644\u0648\u0631\u0645 \u0644\u062f\u064958 \u00a0\u0645\u0631\u064a\u0636\u0629 (56.3%) \u0628\u064a\u0646 2 -5 \u0633\u0645\u060c \u0643\u0645\u0627 \u0644\u0648\u062d\u0638 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062a\u0651\u0639\u0628\u064a\u0631 \u0639\u0646 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0651\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u064a\u0651 \u0627\u0644\u062b\u0651\u0627\u0646\u064a Human epidermal growth factor receptor 2 (HER2) \u0639\u0646\u062f 21 \u0645\u0631\u064a\u0636\u0629 (20.4%) \u0641\u064a \u062d\u064a\u0646 \u0643\u0627\u0646\u062a \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a n=76 (73.8%) \u0625\u064a\u062c\u0627\u0628\u064a\u0651\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0646 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u064a\u0651\u0646 ER \u0648PR \u0645\u0639\u0627\u064b. \u062e\u0636\u0639\u062a \u063a\u0627\u0644\u0628\u064a\u0651\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a n=95 (92.2%) \u0644\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0643\u0627\u0645\u0644 \u0627\u0644\u062b\u0651\u062f\u064a \u0648\u0644\u0644\u0639\u0644\u0627\u062c\u064a\u0646 \u0627\u0644\u0625\u0634\u0639\u0627\u0639\u064a\u0651 \u0648\u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651 \u0628\u0639\u062f \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u062c\u0631\u0627\u062d\u064a\u0651 n=89 (86.4%). \u0644\u0645 \u062a\u0643\u0646 \u0627\u0644\u0641\u0648\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651\u0627\u064b \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0644\u062f\u0649 \u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u0633\u0651\u0627\u0628\u0642\u0629 \u0628\u064a\u0646 \u0630\u0631\u0627\u0639\u064a\u0651 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u0628\u0627\u0633\u062a\u062b\u0646\u0627\u0621 \u0648\u062c\u0648\u062f \u0646\u0632\u0639\u0629 trend \u0644\u0627\u0632\u062f\u064a\u0627\u062f \u0639\u062f\u062f \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0645\u0641\u064a\u0651\u0629 \u0627\u0644\u0645\u0646\u062e\u0631\u0637\u0629 \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062a\u0651\u0639\u0628\u064a\u0631 \u0639\u0646 \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0651 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0648\u0627\u0644\u0628\u0631\u0648\u062c\u0633\u062a\u0631\u0648\u0646 \u0645\u0639\u0627\u064b \u0641\u064a \u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f (\u0627\u0644\u062c\u062f\u0648\u0644 2).<\/span><\/p>\n

\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0623\u0644\u064a\u0644 <\/strong>CYP2D6*10<\/em> \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n

\u0628\u064a\u0651\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0633\u0651\u0644\u0633\u0644\u0629 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062b\u0651\u0644\u0627\u062b\u0629 \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 (\u0627\u0644\u0634\u0651\u0643\u0644 1) \u062d\u064a\u062b \u0646\u064f\u0645\u0651\u0637\u062a 78 \u0645\u0631\u064a\u0636\u0629 (75.7%) \u0639\u0644\u0649 \u0623\u0646\u0651\u0647\u0646\u0651 \u0645\u062a\u0645\u0627\u062b\u0644\u0627\u062a \u0627\u0644\u0632\u0651\u064a\u062c\u0648\u062a \u0644\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 CC\u060c \u0641\u064a \u062d\u064a\u0646 \u062d\u0645\u0644\u062a 12 \u0645\u0631\u064a\u0636\u0629 (11.7%) \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u0651\u064a\u062c\u0648\u062a CT\u060c \u0648\u0643\u0627\u0646\u062a 13 \u0645\u0631\u064a\u0636\u0629 (12.6%) \u0645\u0646 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u0651\u064a\u062c\u0648\u062a \u0644\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0645\u062a\u063a\u0627\u064a\u0631 TT. \u0648\u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0651\u0627\u0641\u0631 T \u0646\u0633\u0628\u0629 \u0642\u062f\u0631\u0647\u0627 18.4% \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u062d\u064a\u062b \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631\u0647 \u0641\u064a \u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 19.7% \u0641\u064a \u062d\u064a\u0646 \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631\u0647 16.7% \u0641\u064a \u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f. \u0623\u0645\u0651\u0627 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 C \u0641\u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631\u0647 \u0646\u0633\u0628\u0629 \u0642\u062f\u0631\u0647\u0627 81.6% \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0648\u0628\u0646\u0633\u0628\u0629\u064d \u0642\u062f\u0631\u0647\u0627 80.3% \u0641\u064a \u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u064083.3% \u0641\u064a \u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u060c \u0648\u0644\u0645 \u064a\u0648\u062c\u062f \u0641\u0627\u0631\u0642\u064c \u0630\u0648 \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629\u064d \u0641\u064a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0628\u064a\u0646 \u0630\u0631\u0627\u0639\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 (P<\/em>=0.585).<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u0627\u0644\u062c\u062f\u0648\u0644 (2): \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0651\u0629 \u0648\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0648\u0631\u0645 \u0648\u0627\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629<\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0645\u062b\u0627\u0628\u062a\u0627\u062a<\/strong><\/span><\/td>\n\u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f<\/strong><\/span><\/p>\n

n=42<\/strong><\/span><\/p>\n

\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/span><\/td>\n

\u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629<\/strong><\/span><\/p>\n

n=61<\/strong><\/span><\/p>\n

\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/span><\/td>\n

\u0625\u062c\u0645\u0627\u0644\u064a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a<\/strong><\/span><\/p>\n

n=103<\/strong><\/span><\/p>\n

\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/span><\/td>\n

\u0642\u064a\u0645\u0629 <\/strong>P<\/em><\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0639\u0645\u0631 \u0639\u0646\u062f \u0627\u0644\u062a\u0651\u0634\u062e\u064a\u0635<\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a<\/span><\/td>\n49.1 \u00b18.54<\/span><\/td>\n48.73 \u00b19.4<\/span><\/td>\n48.88 \u00b19.01<\/span><\/td>\n0.368<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0637\u0651\u0645\u062b\u064a\u0651\u0629 \u0639\u0646\u062f \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u0631\u0636<\/strong><\/span><\/td>\n<\/tr>\n
\u0642\u0628\u0644 \u0633\u0646 \u0627\u0644\u0625\u064a\u0651\u0627\u0633<\/span><\/td>\n13 (31.0)<\/span><\/td>\n20 (32.8)<\/span><\/td>\n33 (31.7)<\/span><\/td>\n0.956<\/span><\/td>\n<\/tr>\n
\u0628\u0639\u062f \u0633\u0646 \u0627\u0644\u0625\u064a\u0651\u0627\u0633<\/span><\/td>\n22 (52.4)<\/span><\/td>\n31 (50.8)<\/span><\/td>\n53 (51.5)<\/span><\/td>\n<\/tr>\n
\u062d\u0648\u0644 \u0633\u0646 \u0627\u0644\u0625\u064a\u0651\u0627\u0633<\/span><\/td>\n7 (16.7)<\/span><\/td>\n9 (14.8)<\/span><\/td>\n16 (15.8)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641<\/span><\/td>\n0 (0)<\/span><\/td>\n1 (1.6)<\/span><\/td>\n1 (1.0)<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u062a\u0651\u062f\u062e\u064a\u0646<\/strong><\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u062f\u062e\u0651\u0646\u0629<\/span><\/td>\n32 (76.2)<\/span><\/td>\n51 (83.6)<\/span><\/td>\n83 (80.6)<\/span><\/td>\n0.377<\/span><\/td>\n<\/tr>\n
\u0645\u062f\u062e\u0651\u0646\u0629<\/span><\/td>\n6 (14.3)<\/span><\/td>\n7 (11.5)<\/span><\/td>\n13 (12.6)<\/span><\/td>\n<\/tr>\n
\u0645\u062f\u062e\u0651\u0646\u0629 \u0633\u0627\u0628\u0642\u0629<\/span><\/td>\n4 (9.5)<\/span><\/td>\n2 (3.3)<\/span><\/td>\n6 (5.8)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641<\/span><\/td>\n0 (0)<\/span><\/td>\n1 (1.6)<\/span><\/td>\n1 (1)<\/span><\/td>\n<\/tr>\n
\u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a<\/strong><\/span><\/td>\n<\/tr>\n
\u0644\u0627 \u064a\u0648\u062c\u062f<\/span><\/td>\n31 (73.8)<\/span><\/td>\n43 (70.5)<\/span><\/td>\n74 (71.8)<\/span><\/td>\n0.811<\/span><\/td>\n<\/tr>\n
\u064a\u0648\u062c\u062f<\/span><\/td>\n11 (26.2)<\/span><\/td>\n17 (27.9)<\/span><\/td>\n28 (27.2)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641<\/span><\/td>\n0 (0)<\/span><\/td>\n1 (1.6)<\/span><\/td>\n1 (1)<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629<\/strong><\/span><\/td>\n<\/tr>\n
ER+\/PR+<\/span><\/td>\n26 (61.9)<\/span><\/td>\n50 (82)<\/span><\/td>\n76 (73.8)<\/span><\/td>\n0.060<\/span><\/td>\n<\/tr>\n
ER+\/PR-<\/span><\/td>\n5 (11.9)<\/span><\/td>\n4 (6.6)<\/span><\/td>\n9 (8.7)<\/span><\/td>\n<\/tr>\n
ER-\/PR+<\/span><\/td>\n7 (16.7)<\/span><\/td>\n3 (4.9)<\/span><\/td>\n10 (9.7)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641<\/span><\/td>\n4 (9.5)<\/span><\/td>\n4 (6.6)<\/span><\/td>\n8 (7.8)<\/span><\/td>\n<\/tr>\n
\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a <\/strong>HER2<\/strong><\/span><\/td>\n<\/tr>\n
HER2-<\/span><\/td>\n29 (69)<\/span><\/td>\n33 (54.1)<\/span><\/td>\n62 (60.2)<\/span><\/td>\n0.144<\/span><\/td>\n<\/tr>\n
HER2+<\/span><\/td>\n6 (14.3)<\/span><\/td>\n15 (24.6)<\/span><\/td>\n21 (20.4)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641\u0629<\/span><\/td>\n7 (16.7)<\/span><\/td>\n13 (21.3)<\/span><\/td>\n20 (19.4)<\/span><\/td>\n<\/tr>\n
\u062d\u062c\u0645 \u0627\u0644\u0648\u0631\u0645<\/strong><\/span><\/td>\n<\/tr>\n
Tx<\/span><\/td>\n2 (4.8)<\/span><\/td>\n1 (1.6)<\/span><\/td>\n3 (2.9)<\/span><\/td>\n0.358<\/span><\/td>\n<\/tr>\n
Tis<\/span><\/td>\n1 (2.4)<\/span><\/td>\n0 (0)<\/span><\/td>\n1 (1)<\/span><\/td>\n<\/tr>\n
T1<\/span><\/td>\n6 (14.3)<\/span><\/td>\n4 (6.6)<\/span><\/td>\n10 (9.7)<\/span><\/td>\n<\/tr>\n
T2<\/span><\/td>\n21 (50)<\/span><\/td>\n37 (60.7)<\/span><\/td>\n58 (56.3)<\/span><\/td>\n<\/tr>\n
T3<\/span><\/td>\n6 (14.3)<\/span><\/td>\n13 (21.3)<\/span><\/td>\n19 (18.4)<\/span><\/td>\n<\/tr>\n
T4<\/span><\/td>\n3 (7.1)<\/span><\/td>\n3 (4.9)<\/span><\/td>\n6 (5.8)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641<\/span><\/td>\n3 (7.1)<\/span><\/td>\n3 (4.9)<\/span><\/td>\n6 (5.8)<\/span><\/td>\n<\/tr>\n
\u0627\u0646\u062e\u0631\u0627\u0637 \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0651\u0645\u0641\u064a\u0651\u0629<\/strong><\/span><\/td>\n<\/tr>\n
N0<\/span><\/td>\n13 (31)<\/span><\/td>\n8 (13.1)<\/span><\/td>\n21 (20.4)<\/span><\/td>\n0.052<\/span><\/td>\n<\/tr>\n
N1<\/span><\/td>\n12 (28.6)<\/span><\/td>\n16 (26.2)<\/span><\/td>\n28 (27.2)<\/span><\/td>\n<\/tr>\n
N2<\/span><\/td>\n11 (26.2)<\/span><\/td>\n21 (34.4)<\/span><\/td>\n32 (31.1)<\/span><\/td>\n<\/tr>\n
N3<\/span><\/td>\n3 (7.1)<\/span><\/td>\n13 (21.3)<\/span><\/td>\n16 (15.5)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641<\/span><\/td>\n3 (7.1)<\/span><\/td>\n3 (4.9)<\/span><\/td>\n6 (5.8)<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u062f\u0651\u0631\u062c\u0629<\/span><\/td>\n<\/tr>\n
I<\/span><\/td>\n0 (0)<\/span><\/td>\n1 (1.6)<\/span><\/td>\n1 (1)<\/span><\/td>\n0.476<\/span><\/td>\n<\/tr>\n
II<\/span><\/td>\n23 (54.8)<\/span><\/td>\n27 (44.3)<\/span><\/td>\n50 (48.5)<\/span><\/td>\n<\/tr>\n
III<\/span><\/td>\n13 (31)<\/span><\/td>\n20 (32.8)<\/span><\/td>\n33 (32)<\/span><\/td>\n<\/tr>\n
\u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641<\/span><\/td>\n6 (14.3)<\/span><\/td>\n13 (21.3)<\/span><\/td>\n19 (18.4)<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u062c\u0631\u0627\u062d\u0627\u062a \u0627\u0644\u0633\u0651\u0627\u0628\u0642\u0629<\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0643\u0627\u0645\u0644 \u0627\u0644\u062b\u0651\u062f\u064a (mastectomy)<\/span><\/td>\n41 (97.6)<\/span><\/td>\n54 (88.5)<\/span><\/td>\n95 (92.2)<\/span><\/td>\n0.137<\/span><\/td>\n<\/tr>\n
\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0643\u062a\u0644\u0629 \u0627\u0644\u0648\u0631\u0645\u064a\u0651\u0629 (lumpectomy)<\/span><\/td>\n1 (2.4)<\/span><\/td>\n7 (11.50)<\/span><\/td>\n8 (7.8)<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0627\u062a \u0627\u0644\u0633\u0651\u0627\u0628\u0642\u0629<\/strong><\/span><\/td>\n<\/tr>\n
\u0644\u0645 \u062a\u062e\u0636\u0639 \u0644\u0645\u0639\u0627\u0644\u062c\u0627\u062a \u0633\u0627\u0628\u0642\u0629<\/span><\/td>\n1(2.4)<\/span><\/td>\n0 (0)<\/span><\/td>\n1 (1)<\/span><\/td>\n0.363<\/span><\/td>\n<\/tr>\n
\u0645\u0639\u0627\u0644\u062c\u0629 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0629 \u0641\u0642\u0637<\/span><\/td>\n6 (14.3)<\/span><\/td>\n7 (11.5)<\/span><\/td>\n13 (12.6)<\/span><\/td>\n<\/tr>\n
\u0645\u0639\u0627\u0644\u062c\u0629 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0629 \u0648\u0625\u0634\u0639\u0627\u0639\u064a\u0651\u0629<\/span><\/td>\n35 (83.3)<\/span><\/td>\n54 (88.5)<\/span><\/td>\n89 (86.4)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u064a\u064f\u0628\u064a\u0651\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (3) \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0646\u0651\u0627\u0643\u0633\u0627\u062a (\u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629) \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062c\u064a\u0628\u0627\u062a (\u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f)\u060c \u062d\u064a\u062b \u062a\u0628\u064a\u0651\u0646 \u0623\u0646 13.1% \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 \u064a\u062d\u0645\u0644\u0646 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u0651\u064a\u062c\u0648\u062a CT \u0645\u0642\u0627\u0628\u0644 9.5% \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u060c \u0628\u064a\u0646\u0645\u0627 \u062d\u0645\u0644\u062a 13.1% \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u0651\u064a\u062c\u0648\u062a TT \u0645\u0642\u0627\u0628\u0644 11.9% \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u060c \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642\u064d \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P<\/em>=0.827).<\/span><\/p>\n

\"\u0627\u0644\u0634\u0643\u0644
\u0627\u0644\u0634\u0643\u0644 (1): \u0646\u062a\u0627\u0626\u062c \u0633\u0644\u0633\u0644\u0629 \u0646\u0648\u0627\u062a\u062c \u0627\u0644\u062a\u0636\u062e\u064a\u0645 \u0644\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 100C>T\u060c A. \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0644\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0634\u0627\u0626\u0639 (CC)\u060c B. \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a (CT)\u060c C. \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0644\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0627\u0641\u0631(TT)<\/span><\/strong><\/figcaption><\/figure>\n

\u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0648\u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636<\/strong> DFS <\/strong><\/span><\/p>\n

\u0642\u064f\u064a\u0651\u0645\u062a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u0649 101 \u0645\u0631\u064a\u0636\u0629 \u062d\u064a\u062b \u0627\u0633\u062a\u064f\u0628\u0639\u0650\u062f\u062a \u0645\u0631\u064a\u0636\u062a\u0627\u0646 \u0628\u0633\u0628\u0628 \u062a\u0648\u0627\u0642\u062a \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u062b\u0628\u0651\u0637\u0627\u062a \u0642\u0648\u064a\u0651\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0645\u0639 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0628\u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0627\u0644\u062b\u0651\u0627\u0646\u064a\u0629 \u0645\u0635\u0627\u0628\u0629 \u0628\u0640DCIS . \u0628\u0644\u063a \u0648\u0633\u064a\u0637 DFS 38.25 \u0634\u0647\u0631\u0627\u064b \u0644\u062f\u0649 \u062d\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a CC \u064830.5 \u0634\u0647\u0631\u0627\u064b \u0644\u062f\u0649 \u062d\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0646\u0651\u0645\u0637 CT \u064843.8 \u0634\u0647\u0631\u0627\u064b \u0644\u062f\u0649 \u062d\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0646\u0651\u0645\u0637 TT\u060c \u0648\u0644\u0643\u0646 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062b\u0651\u0644\u0627\u062b (P=<\/em> 0.926). \u0628\u064a\u0646\u0645\u0627 \u0628\u0644\u063a \u0648\u0633\u064a\u0637 DFS 36.8 \u0634\u0647\u0631\u0627\u064b \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062d\u0627\u0645\u0644\u0627\u062a \u0644\u0623\u0644\u064a\u0644 \u0645\u062a\u063a\u064a\u0651\u0631 \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 (CT + TT) \u0645\u0642\u0627\u0628\u0644 38.25 \u0634\u0647\u0631\u0623 \u0644\u062f\u0649 \u062d\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0627\u0626\u0639\u060c \u0644\u0643\u0646 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0623\u064a\u0636\u0627\u064b (P<\/em>= 0.869) (\u0627\u0644\u0634\u0651\u0643\u0644 2). \u0628\u064a\u0651\u0646 \u0646\u0645\u0648\u0630\u062c \u0627\u0646\u062d\u062f\u0627\u0631 Cox \u0623\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629 (HR=0.528, 95% CI=0.290-0.961, P=<\/em>0.037) \u0648\u0639\u062f\u062f \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0651\u0645\u0641\u064a\u0651\u0629 \u0627\u0644\u0645\u0646\u062e\u0631\u0637\u0629 (HR=1.395, 95% CI=1.074-1.811, P=<\/em>0.012) \u0648\u0646\u0645\u0637 \u0627\u0644\u062c\u0631\u0627\u062d\u0629 (HR=2.364, 95% CI= 1.009-5538, P=<\/em>0.048) \u0643\u0627\u0646\u062a \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0651\u0629 \u0627\u0644\u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0640 DFS \u0641\u064a \u0627\u0644\u062a\u0651\u062d\u0644\u064a\u0644 \u0627\u0644\u0623\u062d\u0627\u062f\u064a. \u0641\u064a \u062d\u064a\u0646 \u0628\u064a\u0651\u0646 \u0627\u0644\u062a\u0651\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u062a\u0639\u062f\u0651\u062f multivariate analysis \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0641\u064a \u0627\u0644\u0640 DFS \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062b\u0651\u0644\u0627\u062b \u062d\u062a\u0651\u0649 \u0628\u0639\u062f \u0627\u0644\u062a\u0651\u0639\u062f\u064a\u0644 \u0644\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0627\u0644\u0633\u0651\u0627\u0628\u0642\u0629 (\u0627\u0644\u062c\u062f\u0648\u0644 4).<\/span><\/p>\n\n\n\n\n\n\n\n
\u0627\u0644\u062c\u062f\u0648\u0644 (3): \u062a\u0648\u0627\u062a\u0631 \u0648\u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0644\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 100<\/strong>C>T<\/strong> \u0628\u064a\u0646 \u0630\u0631\u0627\u0639\u064a\u0651 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629<\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651<\/strong><\/span><\/td>\n\u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0651\u0627\u0647\u062f<\/strong><\/span><\/p>\n

n= 42<\/strong><\/span><\/td>\n

\u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629<\/strong><\/span><\/p>\n

n= 61<\/strong><\/span><\/td>\n

\u0625\u062c\u0645\u0627\u0644\u064a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a<\/strong><\/span><\/p>\n

n=103<\/strong><\/span><\/td>\n

\u0642\u064a\u0645\u0629 <\/strong>P<\/em><\/strong><\/span><\/td>\n<\/tr>\n
CC<\/span><\/td>\n33 (78.6)<\/span><\/td>\n45 (73.8)<\/span><\/td>\n78 (75.7)<\/span><\/td>\n0.827<\/span><\/td>\n<\/tr>\n
CT<\/span><\/td>\n4 (9.5)<\/span><\/td>\n8 \u00a0(13.1)<\/span><\/td>\n12 (11.7)<\/span><\/td>\n<\/tr>\n
TT<\/span><\/td>\n5 (11.9)<\/span><\/td>\n8 (13.1)<\/span><\/td>\n13 (12.6)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\"\u0627\u0644\u0634\u0643\u0644
\u0627\u0644\u0634\u0643\u0644 (2): \u0645\u0646\u062d\u0646\u064a\u0627\u062a \u0643\u0627\u0628\u0644\u0627\u0646 \u0645\u0627\u064a\u0631 \u0644\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636 DFS \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0644\u0640 :100C>T\u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062d\u0627\u0645\u0644\u0627\u062a \u0644\u0623\u062d\u062f \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062b\u0651\u0644\u0627\u062b\u0629 (CC vs CT vs TT) (A)\u060c \u0648\u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062d\u0627\u0645\u0644\u0627\u062a \u0644\u0623\u0644\u064a\u0644 \u0637\u0627\u0641\u0631 \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 (CC vs CT+TT) (B)<\/span><\/strong><\/figcaption><\/figure>\n\n\n\n\n\n\n\n\n
\u0627\u0644\u062c\u062f\u0648\u0644 (4): \u0646\u0645\u0648\u0630\u062c \u0627\u0646\u062d\u062f\u0627\u0631 <\/strong>Cox<\/strong> \u0644\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0646\u0651\u0633\u0628\u064a\u0651\u0629<\/strong> \u0644\u0640<\/strong>DFS <\/strong><\/span><\/td>\n<\/tr>\n
Multivariate*<\/strong><\/span><\/td>\nUnivariate<\/strong><\/span><\/td>\n\u00a0<\/strong><\/span><\/td>\n<\/tr>\n
P<\/em><\/strong><\/span><\/td>\n95% CI<\/strong><\/span><\/td>\nHR<\/strong><\/span><\/td>\nP<\/em><\/strong><\/span><\/td>\n95% CI<\/strong><\/span><\/td>\nHR<\/strong><\/span><\/td>\nGenotype<\/strong><\/span><\/td>\n<\/tr>\n
–<\/span><\/td>\n–<\/span><\/td>\nReference<\/span><\/td>\n–<\/span><\/td>\n–<\/span><\/td>\nReference<\/span><\/td>\nCC<\/span><\/td>\n<\/tr>\n
0.744<\/span><\/td>\n0.476-2.822<\/span><\/td>\n1.159<\/span><\/td>\n0.712<\/span><\/td>\n0.542-2.450<\/span><\/td>\n1.152<\/span><\/td>\nCT<\/span><\/td>\n<\/tr>\n
0.855<\/span><\/td>\n0.423-2.042<\/span><\/td>\n0.929<\/span><\/td>\n0.934<\/span><\/td>\n0.456-2.058<\/span><\/td>\n0.969<\/span><\/td>\nTT<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*\u062a\u0645 \u0627\u0644\u062a\u0651\u0639\u062f\u064a\u0644 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0651\u0629 \u0648\u0646\u0645\u0637 \u0627\u0644\u062c\u0631\u0627\u062d\u0629<\/span><\/p>\n

HR, hazard ratio; CI, confidence interval<\/span><\/p>\n

\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629<\/strong> Discussion <\/strong><\/span><\/p>\n

\u064a\u064f\u0639\u062f\u0651 CYP2D6*10<\/em> \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0623\u0643\u062b\u0631 \u0627\u0646\u062a\u0634\u0627\u0631\u0627\u064b \u0644\u062f\u0649 \u0627\u0644\u0634\u0651\u0631\u0642 \u0622\u0633\u064a\u0648\u064a\u0651\u064a\u0646 \u0628\u0646\u0633\u0628\u0629 \u062a\u0635\u0644 \u0625\u0644\u0649 43.5% \u0648\u0628\u062a\u0648\u0627\u062a\u0631\u0627\u062a\u064d \u0645\u0646\u062e\u0641\u0636\u0629\u064d \u0646\u0633\u0628\u064a\u0651\u0627\u064b \u0639\u0646\u062f \u0628\u0627\u0642\u064a \u0627\u0644\u0625\u062b\u0646\u064a\u0651\u0627\u062a\u060c \u0648\u062a\u064f\u0642\u062f\u0651\u0631 \u0646\u0633\u0628\u0629 \u062a\u0648\u0627\u062a\u0631\u0647 6.7% \u0641\u064a \u0627\u0644\u0634\u0651\u0631\u0642 \u0627\u0644\u0623\u0648\u0633\u0637(PharmGKB. CYP2D6<\/em> Frequency Table,2021) . \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u062d\u0627\u0644\u064a\u0629\u060c \u062d\u0645\u0644\u062a 25 \u0645\u0631\u064a\u0636\u0629 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631 T \u0648\u0628\u062a\u0648\u0627\u062a\u0631\u064d \u0642\u062f\u0631\u0647 18.4% \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629. \u0648\u0644\u0643\u0646\u060c \u062a\u062c\u062f\u0631 \u0627\u0644\u0625\u0634\u0627\u0631\u0629 \u0625\u0644\u0649 \u0623\u0646\u0651 \u0627\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 100C>T \u0644\u0627 \u064a\u064f\u0633\u062a\u0639\u0645\u0644 \u0641\u064a \u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u0627\u0644\u0623\u0644\u064a\u0644 *10<\/em> \u0641\u062d\u0633\u0628\u060c \u0628\u0644 \u064a\u062f\u062e\u0644 \u0641\u064a \u0627\u0633\u062a\u0639\u0631\u0627\u0641 22 \u0623\u0644\u064a\u0644\u0627\u064b \u0622\u062e\u0631\u060c \u0623\u0647\u0645\u0651\u0647\u0627 \u0627\u0644\u0623\u0644\u064a\u0644 *4<\/em>\u0627\u0644\u0645\u064f\u0639\u0631\u0651\u0641 \u0628\u0627\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 1847G>A\u060c \u0644\u0630\u0644\u0643 \u0648\u0628\u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0644\u062f\u0631\u0627\u0633\u062a\u064a\u0651 \u0627\u0633\u0645\u0627\u0639\u064a\u0644 \u0627\u0644\u062e\u0644\u064a\u0644 \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627 (Ismail Alkhalil et al.<\/em>, 2021) \u0648\u0627\u0644\u0635\u0651\u0627\u0644\u062d\u064a \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627 (AL Salhi et al.<\/em>, 2021) \u0627\u0644\u0633\u0651\u0627\u0628\u0642\u062a\u064a\u0646\u060c \u0627\u0633\u062a\u0637\u0639\u0646\u0627 \u062a\u062d\u062f\u064a\u062f \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0641\u0631\u062f\u0627\u0646\u064a\u0651 haplotype \u0644\u0644\u0623\u0644\u064a\u0644 *10<\/em> \u0644\u062f\u0649 97 \u0645\u0631\u064a\u0636\u0629 \u0645\u0646 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0630\u0627\u062a\u0647\u0627 \u0648\u0627\u0644\u0630\u064a \u0628\u0644\u063a 7.2%\u060c \u0648\u0647\u0648 \u0623\u0639\u0644\u0649 \u0645\u0646 \u0627\u0644\u062a\u0651\u0648\u0627\u062a\u0631 \u0627\u0644\u0645\u0633\u062c\u0651\u0644 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Fuselli \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627 \u0639\u0644\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0627\u0644\u0633\u0648\u0631\u064a\u064a\u0651\u0646 \u0648\u0627\u0644\u0630\u064a \u0642\u064f\u062f\u0651\u0631 \u0628\u06402.94%(Fuselli et al.<\/em>, 2004) . \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0639\u0632\u0649 \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u0625\u0644\u0649 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u062c\u0645\u0647\u0631\u062a\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u0641\u0628\u064a\u0646\u0645\u0627 \u0627\u0642\u062a\u0635\u0631\u062a \u062f\u0631\u0627\u0633\u0629 Fuselli \u0639\u0644\u0649 51 \u0641\u0631\u062f\u0627\u064b \u0633\u0648\u0631\u064a\u0651\u0627\u064b \u0645\u0646 \u0627\u0644\u0634\u0651\u0645\u0627\u0644 \u0627\u0644\u0633\u0651\u0648\u0631\u064a\u060c \u0634\u0645\u0644\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 103 \u0627\u0645\u0631\u0623\u0629 \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0645\u0646 \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0627\u062a \u0627\u0644\u0633\u0651\u0648\u0631\u064a\u0651\u0629. \u0644\u0648\u062d\u0638 \u0623\u064a\u0636\u0627\u064b \u0648\u062c\u0648\u062f \u0627\u062e\u062a\u0644\u0627\u0641\u064d \u0641\u064a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 *10<\/em> \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u062c\u0645\u0647\u0631\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u064a \u062f\u0648\u0644 \u0627\u0644\u062c\u0648\u0627\u0631 \u0645\u062b\u0644 \u0627\u0644\u0639\u0631\u0627\u0642 (13.4%)(Swadi et al.<\/em>, 2019) \u0648\u0627\u0644\u0623\u0631\u062f\u0646 (14.8%)(Zihlif et al.<\/em>, 2012) \u0648\u0641\u0644\u0633\u0637\u064a\u0646 (2%)(Sistonen et al.<\/em>, 2007) \u0648\u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0639\u0632\u0649 \u0625\u0644\u0649 \u0643\u064a\u0641\u064a\u0651\u0629 \u062a\u0639\u064a\u064a\u0646 \u0627\u0644\u0623\u0644\u064a\u0644 *10<\/em>\u060c \u062d\u064a\u062b \u0627\u0639\u062a\u0645\u062f\u062a \u062f\u0631\u0627\u0633\u062a\u0627 \u0627\u0644\u0639\u0631\u0627\u0642 \u0648\u0627\u0644\u0623\u0631\u062f\u0646 \u0639\u0644\u0649 \u062a\u0639\u064a\u064a\u0646 \u0627\u0644\u0623\u0644\u064a\u0644 *10<\/em> \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 100C>T \u0641\u0642\u0637 \u062f\u0648\u0646 \u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0641\u0631\u062f\u0627\u0646\u064a\u0651\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644\u060c \u0627\u0644\u0623\u0645\u0631 \u0627\u0644\u0630\u064a \u0642\u062f \u064a\u064f\u0624\u062f\u0651\u064a \u0625\u0644\u0649 \u062a\u0642\u062f\u064a\u0631\u0627\u062a\u064d \u062e\u0627\u0637\u0626\u0629\u064d \u062a\u0645\u064a\u0644 \u0625\u0644\u0649 \u0627\u0644\u0632\u0651\u064a\u0627\u062f\u0629 \u0641\u064a \u062a\u0639\u064a\u064a\u0646 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 10*<\/em>\u060c<\/em> \u0648\u0645\u0646 \u0627\u0644\u0645\u064f\u062a\u0648\u0642\u0651\u0639 \u0623\u0646 \u064a\u0643\u0648\u0646 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 CYP2D6*10<\/em> \u0644\u062f\u0649 \u0627\u0644\u0639\u0631\u0627\u0642\u064a\u0651\u064a\u0646 \u0648\u0627\u0644\u0623\u0631\u062f\u0646\u064a\u0651\u064a\u0646 \u0642\u0631\u064a\u0628\u0627\u064b \u0645\u0646\u0647 \u0644\u062f\u0649 \u0644\u0644\u0633\u0648\u0631\u064a\u0651\u064a\u0646 \u0646\u0638\u0631\u0627\u064b \u0644\u0635\u063a\u0631 \u0627\u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 (n=51) \u0641\u064a \u0641\u0644\u0633\u0637\u064a\u0646 (Alali et al.<\/em>, 2022).<\/span><\/p>\n

\u0623\u062f\u0651\u0649 \u062a\u0637\u0648\u0651\u0631 \u0645\u0641\u0647\u0648\u0645 \u0627\u0644\u0637\u0651\u0628 \u0627\u0644\u0645\u0634\u062e\u0635\u0646 personalized medicine \u0625\u0644\u0649 \u0627\u0646\u0628\u062b\u0627\u0642 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0628\u062d\u0648\u062b \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062f\u0651\u0648\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0631\u0651\u062a \u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0644\u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0648\u0639\u0644\u0627\u0642\u062a\u0647\u0627 \u0628\u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0641\u064a \u0627\u0644\u062a\u0651\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u064a\u0651\u0629 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\u0627\u0644\u0641\u0631\u0636\u064a\u0651\u0629 \u0645\u0639\u00a0 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0648\u0635\u0651\u0644\u062a \u0625\u0644\u064a\u0647\u0627 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u062c\u062a\u0645\u0639\u0629\u064b \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u062a\u064a \u0627\u0633\u0645\u0627\u0639\u064a\u0644 \u0627\u0644\u062e\u0644\u064a\u0644 \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627 (Ismail Alkhalil et al.<\/em>, 2021) \u0648\u0627\u0644\u0635\u0627\u0644\u062d\u064a \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627 (AL Salhi et al.<\/em>, 2021)\u060c \u0648\u0627\u0644\u062a\u064a \u0623\u0638\u0647\u0631\u062a \u0628\u0642\u064a\u0627 \u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u00a0 \u0623\u0642\u0635\u0631 \u0644\u062f\u0649 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\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong><\/span><\/p>\n

\u0623\u0633\u0647\u0645\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0641\u064a \u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 CYP2D6*10 <\/em>\u0648\u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0644\u0644\u0627\u0633\u062a\u0628\u062f\u0627\u0644 100C>T \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u062b\u062f\u064a \u0633\u0648\u0631\u064a\u0651\u0627\u062a\u060c \u0643\u0645\u0627 \u0628\u064a\u0646\u0651\u062a \u063a\u064a\u0627\u0628\u0627\u064b \u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 10*<\/em> \u0641\u064a \u0646\u0643\u0633 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0628\u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646. \u0623\u0643\u0651\u062f\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0639\u0644\u0649 \u0636\u0631\u0648\u0631\u0629 \u0627\u0633\u062a\u0642\u0635\u0627\u0621 \u0623\u0644\u0627\u0626\u0644 \u0623\u062e\u0631\u0649 \u0648\u062a\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0651\u0632\u0629 \u0644\u0640 CYP2D6*<\/em> \u0648\u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0624\u062b\u0651\u0631 \u0641\u064a \u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0648\u0630\u0644\u0643 \u0628\u0647\u062f\u0641 \u062a\u0639\u064a\u064a\u0646 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0638\u0651\u0627\u0647\u0631\u064a\u0651\u0629 \u0628\u062f\u0642\u0651\u0629 \u0623\u0643\u0628\u0631 \u0648\u0645\u0643\u0627\u0645\u0644\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0648\u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u062a\u0651\u0628\u0627\u064a\u0646\u0627\u062a \u0641\u064a \u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u064a\u064f\u0639\u062f\u0651 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0623\u0643\u062b\u0631 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0651\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0646\u062a\u0634\u0627\u0631\u0627\u064b \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645\u060c \u062d\u064a\u062b \u0642\u064f\u062f\u0651\u0631 \u0639\u062f\u062f \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u0629 \u0628\u06402.3 \u0645\u0644\u064a\u0648\u0646 \u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0639\u0627\u0645 2020…
\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":260,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-153","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-135","volume-9","year-10"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=153"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/153\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/260"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}