{"id":158,"date":"2023-07-01T11:49:05","date_gmt":"2023-07-01T11:49:05","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=158"},"modified":"2024-07-13T15:28:39","modified_gmt":"2024-07-13T15:28:39","slug":"%d8%aa%d8%ad%d8%b6%d9%8a%d8%b1-%d9%88%d8%aa%d9%82%d9%8a%d9%8a%d9%85-%d9%81%d9%8a-%d8%a7%d9%84%d8%b2%d8%ac%d8%a7%d8%ac-%d9%84%d8%a3%d9%82%d8%b1%d8%a7%d8%b5-%d9%85%d9%8f%d8%b9%d8%af%d9%91%d9%8e%d9%84","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=158","title":{"rendered":"\u062a\u062d\u0636\u064a\u0631 \u0648\u062a\u0642\u064a\u064a\u0645 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c \u0644\u0623\u0642\u0631\u0627\u0635 \u0645\u064f\u0639\u062f\u0651\u064e\u0644\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0645\u0646 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0628\u062f\u064a \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0645\u0633\u0627\u0648\u0626 \u0639\u062f\u064a\u062f\u0629\u060c \u0645\u0646 \u0628\u064a\u0646\u0647\u0627 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u062e\u0635\u0648\u0635\u0627\u064b \u0641\u064a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0630\u0627\u062a \u0646\u0635\u0641 \u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0627\u0644\u0642\u0635\u064a\u0631\u060c \u0625\u0636\u0627\u0641\u0629\u064b \u0625\u0644\u0649 \u062a\u0623\u0631\u062c\u062d \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u064a\u0629 \u0648\u0627\u0644\u0630\u064a \u064a\u0633\u0628\u0628 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062c\u0627\u0646\u0628\u064a\u0629 \u063a\u064a\u0631 \u0645\u0631\u063a\u0648\u0628\u0629. \u0641\u064a \u062d\u064a\u0646 \u0623\u0646\u0651\u064e \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0645\u0639\u062f\u0651\u064e\u0644\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u062a\u0624\u0645\u0646 \u062a\u0648\u0627\u0641\u0631\u0627\u064b \u062d\u064a\u0648\u064a\u0627\u064b \u0623\u0641\u0636\u0644\u060c \u0648\u062a\u0643\u0631\u0627\u0631 \u062c\u0631\u0639\u0627\u062a \u0623\u0642\u0644\u0651\u060c \u0645\u0627 \u064a\u062d\u0633\u0651\u0646 \u0645\u0646 \u0645\u0637\u0627\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u060c \u0648\u064a\u0632\u064a\u062f \u0643\u0641\u0627\u0621\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u064a\u0642\u0644\u0651\u0644 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 [1]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0639\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0630\u0627\u062a \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0645\u062f\u064a\u062f (Extended release) \u0645\u0646 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0645\u0639\u062f\u0644\u0629 \u0627\u0644\u062a\u062d\u0631\u0631\u060c \u062d\u064a\u062b \u064a\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0645\u0646\u0647\u0627 \u0628\u0628\u0637\u0621 \u0645\u0639 \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u064a\u0629 \u0636\u0645\u0646 \u0627\u0644\u0647\u0627\u0645\u0634 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0644\u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629 \u0645\u0646 \u0627\u0644\u0648\u0642\u062a\u060c \u062a\u062a\u0631\u0627\u0648\u062d \u0639\u0627\u062f\u0629\u064b \u0628\u064a\u0646 8-12 \u0633\u0627\u0639\u0629 [2]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062a\u0645\u064a\u0632 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062c\u0631\u0639\u064a\u0629 \u0645\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0639\u0646 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0630\u0627\u062a \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a \u0628\u0645\u0627 \u064a\u0644\u064a:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062e\u0641\u064a\u0636 \u062a\u0648\u0627\u062a\u0631 \u0648\u0634\u062f\u0651\u064e\u0629 \u0627\u0644\u062a\u0651\u064e\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u062c\u0647\u0627\u0632\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0643\u0645\u064a\u0651\u0629 \u0643\u064f\u0644\u064a\u0651\u064e\u0629 \u0623\u0642\u0644 \u0645\u0646 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u062e\u0641\u0651\u0636 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0645\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u062d\u0631\u0631 \u062a\u0645\u0648\u062c \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u064a\u0629\u060c \u0648\u062e\u0627\u0635\u0651\u064e\u0629\u064b \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u0646\u0627\u0641\u0630\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u0636\u064a\u0651\u0642\u0629.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062d\u0643\u0651\u0645 \u0623\u0643\u0628\u0631 \u0628\u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u062f\u0645\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062d\u0633\u0651\u064f\u0646 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062d\u0633\u064a\u0646 \u0645\u0637\u0627\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062e\u0641\u064a\u0636 \u0639\u062f\u062f \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0645\u0623\u062e\u0648\u0630\u0629 \u0648\u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0651\u064e\u0623\u062b\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0623\u062b\u0646\u0627\u0621 \u0641\u062a\u0631\u0627\u062a \u0627\u0644\u0646\u0648\u0645 \u0644\u064a\u0644\u0627\u064b \u062d\u064a\u062b \u0644\u0627 \u064a\u0648\u062c\u062f \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0644\u0623\u062e\u0630 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062e\u0641\u0636 \u0645\u062a\u0648\u0633\u0637 \u0643\u0644\u0641\u0629 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0644\u0628\u0639\u0636 \u0627\u0644\u0623\u062f\u0648\u064a\u0629. [3,4]<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0645\u0643\u0646 \u0627\u0644\u0648\u0635\u0648\u0644 \u0644\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u062f\u064a\u062f \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0638\u0645 \u0645\u062e\u062a\u0644\u0641\u0629:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0638\u0645 \u0627\u0644\u0642\u0648\u0627\u0644\u0628 \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 Hydrophilic matrix systems.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0638\u0645 \u0627\u0644\u0642\u0648\u0627\u0644\u0628 \u0627\u0644\u0628\u0644\u0645\u0631\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u0646\u062d\u0644\u0629 Insoluble Polymer Matrix.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0646\u0638\u0645 \u0627\u0644\u062d\u0644\u0648\u0644\u064a\u0629 Osmotic Systems.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0646\u0638\u0645 \u0645\u0636\u0628\u0648\u0637\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0628\u0627\u0644\u063a\u0634\u0627\u0621 Membrane-Controlled Systems.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0638\u0645 \u0627\u0644\u0627\u062d\u062a\u0628\u0627\u0633 \u0627\u0644\u0645\u0639\u062f\u064a (Gastroretention Systems).[5]<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0627\u062e\u062a\u064a\u0627\u0631 \u0646\u0638\u0645 \u0627\u0644\u0642\u0648\u0627\u0644\u0628 \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 \u0648\u0627\u0644\u0645\u062d\u062a\u0628\u0633\u0629 \u0645\u0639\u062f\u064a\u0627\u064b\u060c \u0644\u062a\u062d\u0636\u064a\u0631 \u0623\u0642\u0631\u0627\u0635 \u0645\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u062d\u0631\u0631 \u0644\u0645\u0627\u062f\u0629 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644\u060c \u0648\u0641\u064a\u0647\u0627 \u064a\u064f\u0645\u0632\u062c \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0645\u0639 \u0628\u064e\u0644\u0652\u0645\u064e\u0631 \u0645\u062d\u0628 \u0644\u0644\u0645\u0627\u0621 \u0648\u0642\u0627\u0628\u0644 \u0644\u0644\u0627\u0646\u062a\u0628\u0627\u062c \u0628\u0634\u0643\u0644 \u0645\u0633\u062d\u0648\u0642 \u0623\u0648 \u062d\u062b\u064a\u0631\u0627\u062a\u060c \u0648\u064a\u064f\u062d\u0636\u0651\u064e\u0631 \u0627\u0644\u0642\u0631\u0635 \u0641\u064a \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0628\u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0628\u0627\u0634\u0631 \u0623\u0648 \u0628\u0627\u0644\u062a\u062d\u062b\u064a\u0631 \u0627\u0644\u062c\u0627\u0641 (\u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0636\u0627\u0639\u0641). \u0639\u0646\u062f \u062a\u0639\u0631\u0651\u0636 \u0627\u0644\u0642\u0631\u0635 \u0644\u0644\u0633\u0648\u0627\u0626\u0644 \u064a\u0628\u062f\u0623 \u0627\u0644\u0628\u064e\u0644\u0652\u0645\u064e\u0631 \u0628\u0627\u0644\u0627\u0646\u062a\u0628\u0627\u062c \u0648\u064a\u0634\u0643\u0650\u0651\u0644 \u0647\u0644\u0627\u0645\u0629 \u0645\u0627\u0626\u064a\u0629\u060c \u064a\u062a\u062d\u0631\u0651\u0631 \u0645\u0646\u0647\u0627 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0627\u0644\u0645\u062d\u062a\u062c\u0632 \u0628\u064a\u0646 \u0633\u0644\u0627\u0633\u0644 \u0627\u0644\u0628\u064e\u0644\u0652\u0645\u064e\u0631 \u0628\u0628\u0637\u0621\u060c \u0623\u0648 \u064a\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u0622\u0643\u0644 \u0627\u0644\u0647\u0644\u0627\u0645\u0629 \u0648\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0627\u0644\u0645\u062d\u062a\u062c\u0632 \u0636\u0645\u0646\u0647\u0627\u060c [5] \u0648\u0644\u0636\u0645\u0627\u0646 \u0627\u062d\u062a\u0628\u0627\u0633 \u0627\u0644\u0634\u0651\u064e\u0643\u0644 \u0627\u0644\u062c\u0631\u0639\u064a \u0641\u064a \u0627\u0644\u0645\u0639\u062f\u0629 \u062a\u0645\u0651\u064e \u0625\u0636\u0627\u0641\u0629 \u0628\u064a\u0643\u0631\u0628\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0643\u0645\u0627\u062f\u0629 \u0645\u0648\u0644\u062f\u0629 \u0644\u0644\u063a\u0627\u0632 \u0639\u0646\u062f \u062a\u0645\u0627\u0633\u0647\u0627 \u0645\u0639 \u0627\u0644\u0648\u0633\u0637 \u0627\u0644\u0645\u0639\u062f\u064a \u0627\u0644\u062d\u0645\u0636\u064a \u062a\u0624\u064e\u0645\u0646 \u0627\u0644\u0637\u0641\u0648 \u060c \u0643\u0645\u0627 \u0623\u0646\u0651\u064e \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0645\u0651\u064e \u0627\u062e\u062a\u064a\u0627\u0631\u0647\u0627 \u062a\u0628\u062f\u064a \u062e\u0648\u0627\u0635\u0651 \u0627\u0644\u062a\u0635\u0627\u0642 \u062d\u064a\u0648\u064a \u062c\u064a\u062f\u0629.[6,7] <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0627\u062f\u0629 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0647\u064a \u0637\u0644\u064a\u0639\u0629 \u062f\u0648\u0627\u0621 \u0644\u0644\u0635\u0627\u062f \u0627\u0644\u062d\u064a\u0648\u064a \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0646\u062a\u0645\u064a \u0625\u0644\u0649 \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0627\u0644\u0633\u064a\u0641\u0627\u0644\u0648\u0633\u0628\u0648\u0631\u064a\u0646\u0627\u062a\u060c \u0648\u0647\u0648 \u0641\u0639\u0651\u0627\u0644 \u062a\u062c\u0627\u0647 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0627\u0644\u062c\u0631\u0627\u062b\u064a\u0645 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0648\u0633\u0644\u0628\u064a\u0629 \u0627\u0644\u063a\u0631\u0627\u0645\u060c \u0648\u064a\u0633\u062a\u062e\u062f\u0645 \u0641\u064a \u0627\u0644\u0625\u0646\u062a\u0627\u0646\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u062c\u0631\u0627\u062b\u064a\u0645 \u0645\u062a\u062d\u0633\u0651\u0633\u0629 \u0644\u0647. \u064a\u064f\u0635\u0646\u0641 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0641\u064a \u0646\u0638\u0627\u0645 \u0627\u0644\u062a\u0635\u0646\u064a\u0641 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a \u0627\u0644\u062d\u064a\u0648\u064a Biopharmaceutical Classification System (BCS) \u0636\u0645\u0646 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0635\u0641 \u0627\u0644\u062b\u0627\u0646\u064a [8]\u060c \u0623\u064a \u0623\u0646\u0651\u064e\u0647 \u064a\u0645\u0644\u0643 \u0630\u0648\u0628\u0627\u0646\u064a\u0629 \u0645\u0646\u062e\u0641\u0636\u0629 \u0648\u0646\u0641\u0627\u0630\u064a\u0629 \u0639\u0627\u0644\u064a\u0629. \u064a\u062a\u0631\u0627\u0648\u062d \u062a\u0648\u0627\u0641\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a \u0628\u064a\u0646 37-52% \u0645\u0639 \u0623\u0648 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0637\u0639\u0627\u0645 \u0641\u064a \u0627\u0644\u0645\u0639\u062f\u0629 [9]. \u0648\u0646\u0635\u0641 \u0639\u0645\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a \u0642\u0635\u064a\u0631 \u0646\u0633\u0628\u064a\u0651\u064e\u0627\u064b \u064a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 1.2-1.6 \u0633\u0627\u0639\u0629 [9]. \u064a\u0632\u064a\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0646 \u062e\u0637\u0648\u0631\u0629 \u062a\u0634\u0643\u0651\u0644 \u0645\u0642\u0627\u0648\u0645\u0629 \u062c\u0631\u062b\u0648\u0645\u064a\u0629 [10]\u060c \u0648\u062a\u0633\u0628\u0628 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062c\u0627\u0646\u0628\u064a\u0629 \u0647\u0636\u0645\u064a\u0629 \u0645\u062b\u0644 \u0623\u0644\u0645 \u0641\u064a \u0627\u0644\u0628\u0637\u0646 \u0648\u0627\u0644\u0625\u0633\u0647\u0627\u0644 [9]. \u0646\u062c\u062d Bansal \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0628\u062a\u062d\u0636\u064a\u0631 \u0623\u0642\u0631\u0627\u0635 \u0637\u0627\u0641\u064a\u0629 \u0648\u0644\u0635\u0648\u0642\u0629 \u062d\u064a\u0648\u064a\u0627\u064b \u0645\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0644\u0645\u062f\u0629 24 \u0633\u0627\u0639\u0629\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0633\u0628 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 Poly Ethylene Oxide 303 (PEO 303) \u0645\u0639 HPMC K100M LV CR [11]. \u0643\u0645\u0627 \u0646\u062c\u062d Rao \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0628\u062a\u062d\u0636\u064a\u0631 \u0623\u0642\u0631\u0627\u0635 \u0637\u0627\u0641\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u0639\u062f\u0629 \u0644\u0645\u062f\u0629 12 \u0633\u0627\u0639\u0629\u060c \u0639\u0646\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0633\u0628 \u0645\u0646\u0627\u0633\u0628\u0629 \u0645\u0646 \u0643\u0644\u0651\u064d \u0645\u0646 HPMC K4M \u0648 HPMC K15M\u060c \u0648\u0628\u0627\u0644\u0627\u0633\u062a\u0639\u0627\u0646\u0629 \u0628\u0628\u064a\u0643\u0631\u0628\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0643\u0645\u0627\u062f\u0629 \u0645\u0648\u0644\u062f\u0629 \u0644\u0644\u063a\u0627\u0632 [12]. \u0623\u0645\u0651\u064e\u0627 Manohar \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0641\u0642\u062f \u0646\u062c\u062d\u0648\u0627 \u0628\u062a\u062d\u0636\u064a\u0631 \u0623\u0642\u0631\u0627\u0635 \u0637\u0627\u0641\u064a\u0629 \u0648\u0644\u0635\u0648\u0642\u0629 \u0645\u0639\u062f\u064a\u0627 \u0645\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0644\u0645\u062f\u0629 12 \u0633\u0627\u0639\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0633\u0628 \u0645\u0646\u0627\u0633\u0628\u0629 \u0645\u0646 HPMC K4M \u0648 Carbopol 934p \u0648\u0628\u064a\u0643\u0631\u0628\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 [13]. \u062a\u0645\u0651\u064e \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u063a\u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0639\u0644\u0649 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0639\u062f \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646 chitosan \u0627\u0644\u0623\u0643\u062b\u0631 \u0628\u062d\u062b\u0627\u064b \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u062d\u0627\u0644\u064a\u060c \u0648\u0647\u0648 \u0639\u062f\u064a\u062f \u0633\u0643\u0631\u064a\u062f \u0645\u0648\u062c\u0628 \u0627\u0644\u0634\u062d\u0646\u0629\u060c \u064a\u062a\u0645\u064a\u0632 \u0628\u062a\u0648\u0627\u0641\u0642\u0647 \u0627\u0644\u062d\u064a\u0648\u064a \u0648\u0642\u0627\u0628\u0644\u064a\u062a\u0647 \u0644\u0644\u062a\u062d\u0644\u0644 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0648\u0633\u0645\u064a\u062a\u0647 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629. \u0643\u0645\u0627 \u064a\u0645\u062a\u0644\u0643 \u0645\u0631\u0648\u0646\u0629 \u0633\u0644\u0627\u0633\u0644 \u0643\u0627\u0641\u064a\u0629 \u0644\u0644\u0627\u062e\u062a\u0631\u0627\u0642 \u0648\u064a\u0648\u0641\u0631 \u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0639\u0628\u0631 \u0622\u0644\u064a\u0629 \u0627\u0644\u0644\u0635\u0642 \u0627\u0644\u0645\u062e\u0627\u0637\u064a \u0644\u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u062c\u0627\u0648\u0631\u0629\u060c \u0648\u0647\u0630\u0627 \u0633\u0628\u0628 \u0623\u0647\u0645\u064a\u062a\u0647 \u0627\u0644\u0643\u0628\u064a\u0631\u0629. [14]<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong> <strong>Materials and methods<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f <\/strong><strong>Materials<\/strong><strong>: <\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 (Cefuroxime Axetil) \u0645\u0646 \u0634\u0631\u0643\u0629 (Covelant, India)\u060c \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 p934(Carbopol 934p)\u00a0 \u0645\u0646 \u0634\u0631\u0643\u0629 (Lubrizol \u2013 India)\u060c \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0628\u0631\u0648\u0628\u064a\u0644 \u0645\u064a\u062b\u064a\u0644 \u0633\u064a\u0644\u0644\u0648\u0632 (HPMC K4M-K15M) \u0645\u0646 \u0634\u0631\u0643\u0629 (Lubrizol \u2013 India)\u060c \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646 (Chitosan) \u0645\u0646 \u0634\u0631\u0643\u0629 (Sigma, Germany) \u060c \u0628\u064a\u0643\u0631\u0628\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 (NaHCO3) \u0645\u0646 \u0634\u0631\u0643\u0629 (Nitrika, India)\u060c \u0627\u0644\u0644\u0627\u0643\u062a\u0648\u0632 \u0627\u0644\u0645\u062c\u0641\u0641 \u0628\u0627\u0644\u0625\u0631\u0630\u0627\u0630 (Spray-Dried Lactose)\u00a0 \u0645\u0646 \u0634\u0631\u0643\u0629 (Chempifine, India)\u060c \u0634\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0632\u064a\u0648\u0645 (Magnesium Stearate) \u0645\u0646 \u0634\u0631\u0643\u0629 (Nitrika, India)\u060c \u062b\u0627\u0646\u064a \u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0633\u064a\u0644\u064a\u0643\u0648\u0646 \u0627\u0644\u063a\u0631\u0648\u0627\u0646\u064a (Aerosil) \u0645\u0646 \u0634\u0631\u0643\u0629 (Chempifine, India).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0623\u062c\u0647\u0632\u0629 <\/strong><strong>Equipments<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a\u0651 UV (UPS EAST 1500 VA, T80, UV Spectrophotometer)\u060c \u0633\u0631\u0639\u0629 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 (Pharmatest)\u060c \u0622\u0644\u0629 \u0636\u063a\u0637 \u0645\u062e\u0628\u0631\u064a\u0629 \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0645\u0643\u0628\u0633 (ERWEKA AR 402, Type EK0, Germany)\u060c \u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633 (Sartorius GP 2102,Germany)\u060c \u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633 \u062a\u062d\u0644\u064a\u0644\u064a (Sartorius weighing &#8211; Goettingen, Germany)\u060c \u0645\u0646\u0627\u062e\u0644 \u062f\u0633\u062a\u0648\u0631\u064a\u0651\u0629 (CISA- Sieve Shaker RP -09, Spain)\u060c \u0642\u064a\u0627\u0633 \u062f\u0631\u062c\u0629 \u062d\u0645\u0648\u0636\u0629 \u0627\u0644\u0648\u0633\u0637 (HANNA pH211- Microprocessor pH Meter)\u060c \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0651\u0629 Digital ultrasonic cleaner PHYLO\u060c l\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0642\u0633\u0627\u0648\u0629 \u0648\u0627\u0644\u0642\u0637\u0631 \u0648\u0627\u0644\u0633\u0645\u0627\u0643\u0629 ERWEKA TBH 300S\u060c \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0647\u0634\u0627\u0634\u0629 ERWEKA TAR 20\u060c \u062a\u0642\u0637\u064a\u0631 \u0627\u0644\u0645\u0627\u0621 Automatic water still DESA 0041 SHIN- SAENG.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Methods<\/strong><strong>:<\/strong><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u062d\u0636\u064a\u0631 \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064f\u0636\u0651\u064e\u0631\u062a \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 (125\u0645\u063a) \u0628\u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0628\u0627\u0634\u0631\u060c \u0627\u0633\u062a\u0639\u0645\u0644\u062a \u0641\u064a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0623\u0631\u0628\u0639\u0629 \u0639\u0634\u0631 \u0627\u0644\u0645\u064f\u062d\u0636\u064e\u0651\u0631\u064e\u0629 \u0628\u064a\u0643\u0631\u0628\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0628\u062a\u0631\u0643\u064a\u0632 10% \u0643\u0639\u0627\u0645\u0644 \u0645\u0648\u0644\u062f \u0644\u0644\u063a\u0627\u0632\u060c \u0648\u0634\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0632\u064a\u0648\u0645 \u0628\u062a\u0631\u0643\u064a\u0632 2% \u0643\u0639\u0627\u0645\u0644 \u0645\u0632\u0644\u0642\u060c \u0648\u0627\u0644\u0623\u064a\u0631\u0648\u0632\u064a\u0644 \u0628\u062a\u0631\u0643\u064a\u0632 0.5% \u0643\u0645\u062d\u0633\u0646 \u0644\u0644\u0627\u0646\u0633\u064a\u0627\u0628\u060c \u0648\u0627\u0644\u0644\u0627\u0643\u062a\u0648\u0632 \u0627\u0644\u0645\u062c\u0641\u0641 \u0628\u0627\u0644\u0625\u0631\u0630\u0627\u0630 \u0643\u0645\u064a\u0629 \u0643\u0627\u0641\u064a\u0629 \u062d\u062a\u0649 )300\u0645\u063a) \u0643\u0639\u0627\u0645\u0644 \u0645\u0645\u062f\u062f\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0648\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 1 \u0648\u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0643\u0639\u0648\u0627\u0645\u0644 \u0631\u0627\u0628\u0637\u0629 \u0648\u0645\u0634\u0643\u0644\u0629 \u0644\u0644\u0642\u0627\u0644\u0628\u060c \u062d\u064f\u0636\u0631\u062a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0648\u0641\u0642 \u0627\u0644\u062a\u0631\u062a\u064a\u0628 \u0627\u0644\u0622\u062a\u064a:<\/span><\/p>\n<ol style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u064f\u062e\u0644\u062a \u0627\u0644\u0645\u0643\u0648\u0646\u0627\u062a \u062c\u0645\u064a\u0639\u0647\u0627 \u0645\u0627 \u0639\u062f\u0627 \u0627\u0644\u0623\u064a\u0631\u0648\u0632\u064a\u0644 \u0648\u0634\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0632\u064a\u0648\u0645 \u0639\u0644\u0649 \u0645\u0646\u062e\u0644 \u0631\u0642\u0645 60mesh \u0642\u064a\u0627\u0633 \u0641\u062a\u062d\u0627\u062a\u0647 250 \u0645\u0643\u0645.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u064f\u0632\u0646 \u0643\u0644 \u0645\u0633\u062d\u0648\u0642 \u0639\u0644\u0649 \u062d\u062f\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633.<\/span><\/li>\n<\/ol>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u064f\u0632\u062c\u062a \u0643\u0644 \u0645\u0646 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0648\u0628\u064a\u0643\u0631\u0628\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 \u0648\u0627\u0644\u0644\u0627\u0643\u062a\u0648\u0632 \u0627\u0644\u0645\u062c\u0641\u0641 \u0628\u0627\u0644\u0625\u0631\u0630\u0627\u0630.<\/span><\/li>\n<\/ul>\n<ol style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u0636\u064a\u0641 \u0627\u0644\u0623\u064a\u0631\u0648\u0632\u064a\u0644 \u0648\u0634\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0632\u064a\u0648\u0645 \u0645\u0639 \u0627\u0644\u0645\u0632\u062c \u0644\u0645\u062f\u0629 \u062f\u0642\u064a\u0642\u062a\u064a\u0646.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0636\u064f\u063a\u0637 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0646\u0627\u062a\u062c \u0628\u0622\u0644\u0629 \u0636\u063a\u0637 \u0645\u062e\u0628\u0631\u064a\u0629 \u0630\u0627\u062a \u0642\u0637\u0631 \u0645\u0643\u0628\u0633 10 \u0645\u0644\u0645.<\/span><\/li>\n<\/ol>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0651 \u0648\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0627\u0643\u0633\u062a\u064a\u0644:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u062c\u0631\u064a \u0645\u0633\u062d \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a\u0651 \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0651\u0629 \u0636\u0645\u0646 \u0645\u062c\u0627\u0644 190-400 \u0646\u0627\u0646\u0648\u0645\u062a\u0631 \u0644\u062a\u062d\u062f\u064a\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a \u03bbmax. \u0643\u0645\u0627 \u0623\u064f\u062c\u0631\u064a \u0645\u0633\u062d \u0637\u064a\u0641\u064a \u0644\u0634\u0627\u0647\u062f \u064a\u062d\u0648\u064a \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062a\u062f\u0627\u062e\u0644 \u0628\u064a\u0646 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0642\u062f \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064f\u0636\u0651\u064e\u0631\u062a \u0633\u0644\u0633\u0644\u0629 \u0639\u064a\u0627\u0631\u064a\u0629 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0648\u0633\u0637 \u0627\u0646\u062d\u0644\u0627\u0644 \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 \u0630\u064a \u0627\u0644\u062a\u0631\u0643\u064a\u0632 0.07 N \u0648\u0630\u064a 1.15 pH= \u0639\u0644\u0649 \u0627\u0644\u0646\u062d\u0648 \u0627\u0644\u0622\u062a\u064a: \u062d\u064f\u0636\u0651\u064e\u0631 \u0645\u062d\u0644\u0648\u0644 \u0623\u0648\u0644 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0628\u062a\u0631\u0643\u064a\u0632 1000 \u0645\u0643\u063a\/\u0645\u0644 \u0648\u0630\u0644\u0643 \u0628\u0625\u0630\u0627\u0628\u0629 100 \u0645\u063a \u0641\u064a 100 \u0645\u0644 \u0645\u0646 \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 (pH=1.15)\u060c \u0639\u064f\u0631\u0651\u064e\u0636 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0644\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0625\u062a\u0645\u0627\u0645 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u060c \u062b\u0645 \u0623\u064f\u062e\u0630 \u0645\u0646 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0633\u0627\u0628\u0642 3 \u0645\u0644 \u0648\u0645\u064f\u062f\u0651\u062f\u062a \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 100 \u0645\u0644 \u062d\u062a\u0649 \u062e\u0637 \u0627\u0644\u0639\u064a\u0627\u0631 \u0645\u0639 \u0627\u0644\u0645\u0632\u062c, \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u062d\u0644\u0648\u0644 \u062a\u0631\u0643\u064a\u0632\u0647 \u064a\u0633\u0627\u0648\u064a 30 \u0645\u0643\u063a\/\u0645\u0644\u060c \u0633\u064f\u062d\u0628 \u0628\u0639\u062f \u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0645\u0635 \u0645\u0639\u0627\u064a\u064e\u0631 \u0623\u062d\u062c\u0627\u0645 \u0645\u0646\u0627\u0633\u0628\u0629 1\u060c 2\u060c 3\u060c 4\u060c 5\u060c 6\u060c 7\u060c 8 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0633\u0627\u0628\u0642 \u0648\u0645\u064f\u062f\u0651\u062f \u0643\u0644\u0651 \u0645\u0646\u0647\u0627 \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u0629 10 \u0645\u0644 \u0628\u0648\u0633\u0637 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0644\u062a\u062d\u0636\u064a\u0631 \u0645\u062d\u0627\u0644\u064a\u0644 \u0628\u062a\u0631\u0627\u0643\u064a\u0632 \u062a\u0628\u062f\u0623 \u0645\u0646 3 \u0645\u0643\u063a\/\u0645\u0644 \u062d\u062a\u0649 24 \u0645\u0643\u063a\/\u0645\u0644\u060c \u0642\u064a\u0633\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u062d\u0627\u0644\u064a\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a \u0627\u0644\u0628\u0627\u0644\u063a\u0629 280 nm\u060c \u062a\u0645 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 3 \u0645\u0631\u0627\u062a \u0648\u0623\u064f\u062e\u0630\u064e\u062a \u0642\u064a\u0645 \u0627\u0644\u0648\u0633\u0637\u064a \u0648\u062d\u064f\u0633\u064e\u0628\u064e \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a [15,16].<\/span><\/p>\n<table width=\"0\">\n<tbody>\n<tr>\n<td colspan=\"7\" width=\"596\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (1): \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u064e\u0631\u0629 \u0645\u0646 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>HPMC K15M (%) mg<\/strong><\/span><\/td>\n<td width=\"102\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>HPMC K4M<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>(%) mg<\/strong><\/span><\/td>\n<td width=\"93\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>Chitosan<br \/>\n(%) mg<\/strong><\/span><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>Carbopol 934p<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>(%) mg<\/strong><\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>Cefuroxime<br \/>\nAxetil) mg)<\/strong><\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0627\u062f<\/strong><strong>\u0629<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>(\u0645\u063a)<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u00a0 <\/strong><strong>\u00a0<\/strong><strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u0627\u0644\u0635\u064a\u063a<\/strong><\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%5) 15<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F1<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F2<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><span style=\"font-family: 'times new roman', times, serif;\">(%15) 45<\/span><\/td>\n<td width=\"123\"><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F3<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><span style=\"font-family: 'times new roman', times, serif;\">(%20) 60<\/span><\/td>\n<td width=\"123\"><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F4<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F5<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><span style=\"font-family: 'times new roman', times, serif;\">(%15) 45<\/span><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F6<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F7<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><span style=\"font-family: 'times new roman', times, serif;\">(%15) 45<\/span><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F8<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><span style=\"font-family: 'times new roman', times, serif;\">(%20) 60<\/span><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%5) 15<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F9<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><span style=\"font-family: 'times new roman', times, serif;\">(%20) 60<\/span><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F10<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><span style=\"font-family: 'times new roman', times, serif;\">(%15) 45<\/span><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%5) 15<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F11<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><\/td>\n<td width=\"102\"><span style=\"font-family: 'times new roman', times, serif;\">(%15) 45<\/span><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F12<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%5) 15<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F13<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<tr>\n<td width=\"117\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"102\"><\/td>\n<td width=\"93\"><\/td>\n<td width=\"123\"><span style=\"font-family: 'times new roman', times, serif;\">(%10) 30<\/span><\/td>\n<td width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">125<\/span><\/td>\n<td width=\"70\"><span style=\"font-family: 'times new roman', times, serif;\">F14<\/span><\/td>\n<td width=\"1\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0637\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0628\u0639\u062f \u0627\u0644\u0636\u063a\u0637:<\/strong><\/span>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0648\u0632\u0646 Weight Variation Test:<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u062c\u0631\u064a \u0647\u0630\u0627 \u0627\u0644\u0641\u062d\u0635 \u0648\u0641\u0642 \u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0628\u0631\u064a\u0637\u0627\u0646\u064a \u062d\u064a\u062b \u062a\u0645 \u0627\u0646\u062a\u0642\u0627\u0621 20 \u0642\u0631\u0635 \u0628\u0634\u0643\u0644 \u0639\u0634\u0648\u0627\u0626\u064a \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629\u060c \u0648\u0632\u0646\u062a \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0625\u0641\u0631\u0627\u062f\u064a\u0627\u064b \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633 \u0628\u062f\u0642\u0629 \u062a\u0639\u0627\u062f\u0644 0.01 \u063a \u062b\u0645 \u062d\u0633\u0628 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 Average \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0646\u0633\u0628\u064a \u0627\u0644\u0645\u0626\u0648\u064a Percentage Deviation. \u064a\u0635\u0646\u0641 \u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0628\u0631\u064a\u0637\u0627\u0646\u064a 2020\u060c \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0646\u0633\u0628\u064a \u0627\u0644\u0645\u0626\u0648\u064a \u0627\u0644\u0645\u0633\u0645\u0648\u062d \u0644\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (2): [17]<\/span><\/p>\n<table width=\"0\">\n<tbody>\n<tr>\n<td colspan=\"2\" width=\"302\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (2): <\/strong><strong>\u0642\u064a\u0645 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0646\u0633\u0628\u064a \u0627\u0644\u0645\u0626\u0648\u064a \u0627\u0644\u0645\u0633\u0645\u0648\u062d\u0629 \u062d\u0633\u0628<\/strong><strong>BP 2020 <\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"188\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0648\u0633\u0637\u064a\u0651 (\u0645\u0644\u063a)<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>Average Mass<\/strong><\/span><\/td>\n<td width=\"114\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0646\u0633\u0628\u064a \u0627\u0644\u0645\u0626\u0648\u064a \u0627\u0644\u0645\u0633\u0645\u0648\u062d<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>Percentage Deviation<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"188\"><span style=\"font-family: 'times new roman', times, serif;\">80 \u0645\u063a \u0623\u0648 \u0623\u0642\u0644<\/span><\/td>\n<td width=\"114\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>10%<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"188\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0643\u0628\u0631 \u0645\u0646 80 \u0645\u063a \u0648\u0623\u0635\u063a\u0631 \u0645\u0646 250 \u0645\u063a<\/span><\/td>\n<td width=\"114\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>7.5%<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"188\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0643\u0628\u0631 \u0623\u0648 \u064a\u0633\u0627\u0648\u064a 250<\/span><\/td>\n<td width=\"114\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>5%<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0642\u0633\u0627\u0648\u0629 \u0648\u0627\u0644\u0642\u0637\u0631 \u0648\u0627\u0644\u0633\u0645\u0627\u0643\u0629 <\/strong><strong>Hardness, Diameter and Thickness Test<\/strong><strong>:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u062c\u0631\u064a \u0642\u064a\u0627\u0633 \u0627\u0644\u0642\u0633\u0627\u0648\u0629 \u0648\u0627\u0644\u0642\u0637\u0631 \u0648\u0627\u0644\u0633\u0645\u0627\u0643\u0629 \u0644\u0639\u064a\u0646\u0627\u062a \u0645\u0624\u0644\u0641\u0629 \u0645\u0646 6 \u0623\u0642\u0631\u0627\u0635 \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u064e\u0636\u064e\u0651\u0631\u064e\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0642\u0633\u0627\u0648\u0629 \u0648\u0627\u0644\u0642\u0637\u0631 \u0648\u0627\u0644\u0633\u0645\u0627\u0643\u0629 ERWEKA TBH 300S. [18]<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0647\u0634\u0627\u0634\u0629 <\/strong><strong>Friability Test<\/strong><strong>: <\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u062c\u0631\u064a \u0642\u064a\u0627\u0633 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0647\u0634\u0627\u0634\u0629 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u0645\u064f\u062d\u064e\u0636\u064e\u0651\u0631\u064e\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0647\u0634\u0627\u0634\u0629 ERWEKA TAR 20 \u062d\u064a\u062b \u062a\u0645 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0628\u0648\u0632\u0646 20 \u0642\u0631\u0635 \u062b\u0645 \u0648\u0636\u0639\u0647\u0627 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0647\u0627\u0632. \u0634\u064f\u063a\u0651\u0650\u0644 \u0627\u0644\u062c\u0647\u0627\u0632 \u0628\u0633\u0631\u0639\u0629 25 \u062f\u0648\u0631\u0629 \u0628\u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0645\u062f\u0629 4 \u062f\u0642\u0627\u0626\u0642\u060c \u0628\u0639\u062f\u0647\u0627 \u0623\u064f\u062e\u0630\u062a \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0648\u0623\u064f\u0632\u064a\u0644 \u0639\u0646\u0647\u0627 \u0627\u0644\u063a\u0628\u0627\u0631 \u0648\u0648\u0632\u0646\u062a \u0645\u0646 \u062c\u062f\u064a\u062f\u060c \u062a\u064f\u062d\u0633\u0628 \u0642\u064a\u0645\u0629 \u0627\u0644\u0647\u0634\u0627\u0634\u064a\u0629 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u0642\u0629:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">= (Wb-Wa) \/ Wb x 100\u0627\u0644\u0647\u0634\u0627\u0634\u064a\u0629 %<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064a\u062b: Wb \u0648\u0632\u0646 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0642\u0628\u0644 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u060c Wa \u0648\u0632\u0646 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0628\u0639\u062f \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u062a\u0643\u0648\u0646 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0645\u0642\u0628\u0648\u0644\u0629 \u062f\u0633\u062a\u0648\u0631\u064a\u0627\u064b \u0645\u0627 \u0644\u0645 \u062a\u062a\u062c\u0627\u0648\u0632 \u0642\u064a\u0645\u0629 \u0627\u0644\u0647\u0634\u0627\u0634\u064a\u0629 1%.[19]<\/span><\/p>\n<h4 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">3-3-\u00a0\u00a0\u00a0\u00a0 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 Drug Content:<\/span><\/h4>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u062c\u0631\u064a\u062a \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0641\u064a \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u064e\u0636\u064e\u0651\u0631\u064e\u0629\u060c \u062d\u064a\u062b \u0623\u064f\u062e\u0630\u062a 10 \u0623\u0642\u0631\u0627\u0635 \u0645\u0646 \u0643\u0644\u0651 \u0635\u064a\u063a\u0629 \u0648\u0633\u064f\u062d\u0642\u062a\u060c \u062b\u0645 \u0623\u064f\u062e\u0630\u062a \u0639\u064a\u0646\u0629 \u0645\u0643\u0627\u0641\u0626\u0629 \u0644\u0650\u0640 125 \u0645\u0644\u063a \u0648\u0648\u0636\u0639\u062a \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u0629 100 \u0645\u0644 \u0648\u062a\u0645 \u0627\u0644\u062d\u0644 \u0628\u0645\u062d\u0644\u0648\u0644 \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 0.07 \u0646\u0638\u0627\u0645\u064a \u0628\u0627\u0644\u0627\u0633\u062a\u0639\u0627\u0646\u0629 \u0628\u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0651\u064e\u0648\u062a\u064a\u0651\u0629 \u0648\u0623\u064f\u0643\u0645\u0644 \u0627\u0644\u062d\u062c\u0645 \u062d\u062a\u0649 \u062e\u0637 \u0627\u0644\u0639\u064a\u0627\u0631 \u0644\u0646\u062d\u0635\u0644 \u0639\u0644\u0649 \u0645\u062d\u0644\u0648\u0644 \u062a\u0631\u0643\u064a\u0632\u0647 1250 \u0645\u0643\u063a\\\u0645\u0644\u060c \u0628\u0639\u062f\u0647\u0627 \u0631\u064f\u0634\u0651\u064e\u062d\u064e \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0628\u0645\u0631\u0627\u0634\u062d 0.45 \u0645\u064a\u0643\u0631\u0648\u0646 \u0648\u0623\u064f\u062e\u0630 \u0645\u0646 \u0627\u0644\u0631\u0634\u0627\u062d\u0629 1 \u0645\u0644 \u0648\u0646\u064f\u0642\u0644\u062a \u0625\u0644\u0649 \u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u0629 100 \u0645\u0644\u060c \u0648\u0623\u0643\u0645\u0644 \u0627\u0644\u062d\u062c\u0645 \u062d\u062a\u0649 100 \u0645\u0644 \u0628\u0648\u0633\u0637 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644 \u0644\u0646\u062d\u0635\u0644 \u0639\u0644\u0649 \u0645\u062d\u0644\u0648\u0644 \u062a\u0631\u0643\u064a\u0632\u0647 12.5 \u0645\u0643\u063a\\\u0645\u0644\u060c \u062a\u0645\u062a \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0647\u0627\u0626\u064a \u0645\u0646 \u062e\u0644\u0627\u0644 \u0623\u062e\u0630 \u0639\u064a\u0646\u0629 \u0648\u0642\u064a\u0627\u0633 \u0627\u0645\u062a\u0635\u0627\u0635\u0647\u0627 \u0628\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 (280 \u0646\u0627\u0646\u0648\u0645\u062a\u0631) \u0645\u0642\u0627\u0628\u0644 \u0639\u064a\u0627\u0631\u064a \u0628\u062a\u0631\u0643\u064a\u0632 12.5 \u0645\u0643\u063a\\\u0645\u0644\u060c \u0648\u0637\u064f\u0628\u0651\u0650\u0642 \u0627\u0644\u0642\u0627\u0646\u0648\u0646:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 = \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u062c\u0647\u0648\u0644 \/ \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0639\u064a\u0627\u0631\u064a \u00d7 100 [20]<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u062c\u0628 \u0623\u0646 \u062a\u062d\u062a\u0648\u064a \u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0627 \u0644\u0627 \u064a\u0642\u0644 \u0639\u0646 90%\u060c \u0648\u0645\u0627 \u0644\u0627 \u064a\u0632\u064a\u062f \u0639\u0646 110% \u0645\u0646 \u0627\u0644\u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0639\u0646\u0648\u0646\u0629 [21].<\/span><\/p>\n<h3 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">4-\u00a0\u00a0\u00a0\u00a0\u00a0 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 Dissolution Test:<\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u062c\u0631\u064a \u0627\u0644\u0641\u062d\u0635 \u0639\u0644\u0649 6 \u0623\u0642\u0631\u0627\u0635 \u0645\u0646 \u0643\u0644\u0651 \u0635\u064a\u063a\u0629 \u0641\u064a \u062c\u0647\u0627\u0632 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u062d\u0633\u0628 \u0637\u0631\u064a\u0642\u0629 38 USP \u0648\u0641\u0642 \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u0622\u062a\u064a\u0629:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u062c\u0647\u0627\u0632: \u0627\u0644\u062b\u0627\u0646\u064a (\u0627\u0644\u0645\u062c\u062f\u0627\u0641)<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0648\u0633\u0637: 900 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621(0.07 N) \u0648 (pH=1.15)\u060c [21]<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0633\u0631\u0639\u0629 \u0627\u0644\u062f\u0648\u0631\u0627\u0646: 50 \u062f\u0648\u0631\u0629 \u0641\u064a \u0627\u0644\u062f\u0642\u064a\u0642\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629: 37 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629 \u00b1 0.5<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0632\u0645\u0646 \u0627\u0644\u0627\u0639\u062a\u064a\u0627\u0646: 0.5\u060c 1\u060c 2\u060c 3\u060c 4\u060c 5\u060c 6\u060c 8\u060c 10\u060c 12 \u0633\u0627\u0639\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0625\u062c\u0631\u0627\u0621: \u0633\u064f\u062d\u0628\u062a \u0639\u064a\u0646\u0627\u062a \u062d\u062c\u0645 \u0643\u0644\u0651 \u0645\u0646\u0647\u0627 1 \u0645\u0644 \u0639\u0646\u062f \u0627\u0644\u0623\u0632\u0645\u0646\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0648\u0639\u064f\u0648\u0651\u0636 \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0628\u0646\u0641\u0633 \u0627\u0644\u062d\u062c\u0645 \u0645\u0646 \u0627\u0644\u0648\u0633\u0637 \u0627\u0644\u0646\u0642\u064a\u060c \u0645\u064f\u062f\u0651\u062f\u062a \u0627\u0644\u0639\u064a\u0646\u0629 \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u0639\u0627\u064a\u0631\u0629 \u0633\u0639\u062a\u0647 10 \u0645\u0644\u060c \u062b\u0645\u0651\u064e \u0631\u064f\u0634\u062d\u0651\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u062d\u0648\u0628\u0629 \u0628\u0645\u0631\u0627\u0634\u062d \u0645\u064a\u0643\u0631\u0648\u0646\u064a\u0629 0.45 \u0645\u0643\u0645\u060c \u0642\u064a\u0633 \u0628\u0639\u062f \u0630\u0644\u0643 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0644\u0643\u0644 \u0639\u064a\u0646\u0629 \u0628\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 (280 \u0646\u0627\u0646\u0648\u0645\u062a\u0631)\u060c \u062d\u064f\u0633\u0628\u062a \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0641\u064a \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0639\u0627\u062f\u0644\u0629 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 . <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064f\u0633\u0628\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0643\u0645\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 Q% \u0643\u0645\u0627 \u064a\u0644\u064a:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Q%= (C V dr 100)\/Dose\u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Q%= (C 900 10 100)\/125,000<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Q%= 7.2 C<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">C: \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0641\u064a \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">dr: \u0646\u0633\u0628\u0629 \u0627\u0644\u062a\u0645\u062f\u064a\u062f\u060c \u0648\u062a\u0633\u0627\u0648\u064a 10.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">V: \u062d\u062c\u0645 \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u060c \u0648\u064a\u0633\u0627\u0648\u064a 900 \u0645\u0644.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Dose: \u0643\u0645\u064a\u0629 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0641\u064a \u0627\u0644\u0642\u0631\u0635 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u064e\u0631 (\u0645\u0643\u063a). [11,12]<\/span><\/p>\n<h3 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">5-\u00a0\u00a0\u00a0\u00a0\u00a0 \u062a\u0648\u0627\u0641\u0642 \u0646\u0633\u0628 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0645\u0639 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629:<\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645\u0651\u064e \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0645\u0648\u0627\u0641\u0642\u0629 \u062a\u062d\u0631\u0651\u0631 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0646 \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u064e\u0636\u064e\u0651\u0631\u064e\u0629 \u0644\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u0646\u0635 \u0639\u0644\u064a\u0647\u0627 USP38 \u2013 NF 33 \u0644\u0644\u0635\u064a\u063a \u0645\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u0631\u060c \u0648\u062d\u064f\u062f\u0651\u064e\u062f\u062a \u062b\u0644\u0627\u062b \u0646\u0642\u0627\u0637\u00a0 \u0643\u0645\u0627 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 3: [22,23]<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062f\u0631\u0627\u0633\u0629 \u0646\u0645\u0627\u0630\u062c \u062d\u0631\u0643\u064a\u0651\u0629 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c: <\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645\u064e\u0651 \u062d\u0633\u0627\u0628 \u0627\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u062e\u0627\u0635\u064e\u0651\u0629 \u0628\u0643\u0644\u0651 \u0646\u0645\u0648\u0630\u062c \u0645\u0646 \u0646\u0645\u0627\u0630\u062c \u0627\u0644\u062d\u0631\u0643\u064a\u0651\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0644\u0643\u0644\u0651\u0650 \u0635\u064a\u063a\u0629 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062e\u0645\u0633 \u0648\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0623\u0645\u062b\u0644 \u0627\u0644\u0630\u064a \u064a\u0639\u0628\u0631 \u0639\u0646 \u062d\u0631\u0643\u064a\u0651\u0629 \u062a\u062d\u0631\u0651\u0631 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u0629\u060c \u0628\u062d\u064a\u062b \u064a\u0645\u0644\u0643 \u0642\u064a\u0645\u0629 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 R\u00b2 \u0627\u0644\u0623\u0639\u0644\u0649. \u062f\u064f\u0631\u0633\u062a \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u0627\u0644\u0622\u062a\u064a\u0629 \u0644\u062d\u0631\u0643\u064a\u0651\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u0631:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0631\u0651\u062a\u0628\u0629 \u0635\u0641\u0631 Zero order: Qt= K*t<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0631\u0651\u062a\u0628\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 First order: \u00a0\u00a0\u00a0\u00a0Log Qt= Log Q0 \u2013Kt\/ 2.303<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0647\u064a\u063a\u0648\u062a\u0634\u064a Higuchi: \u00a0Qt = KHt<strong><sup>1\/2<\/sup><\/strong><\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0647\u064a\u0643\u0633\u0648\u0646-\u0643\u0631\u0648\u0644 Hixson-crowell: Q<sub>0<\/sub><sup>1<\/sup><strong><sup>\/3<\/sup><\/strong><strong> \u2013 <\/strong>Q<sub>t<\/sub><sup>1<\/sup><strong><sup>\/3<\/sup><\/strong> = KHC.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0648\u0631\u0633\u0645\u0627\u064a\u0631-\u0628\u064a\u0628\u0627\u0633 Korsmeyer-Peppas: F = (Mt \/M) = Kmt<strong><sup>n <\/sup><\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u00a0<\/strong><\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0633\u062a\u062e\u0631\u062c \u0642\u064a\u0645\u0629 (n) \u0645\u0646 \u0627\u0644\u062e\u0637 \u0627\u0644\u0628\u064a\u0627\u0646\u064a \u0644\u0640 log [(Mt\/M)] \u0645\u0642\u0627\u0628\u0644 (log t). <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u062a\u062f\u0644 \u0642\u064a\u0645\u0629 (n) \u0639\u0644\u0649 \u0646\u0645\u0637 \u0627\u0644\u062a\u062d\u0631\u0651\u0631. \u0641\u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u0634\u0651\u0643\u0644 \u0627\u0644\u0627\u0633\u0637\u0648\u0627\u0646\u064a:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 (n) \u062a\u0633\u0627\u0648\u064a 0.45 \u0623\u0648 \u0623\u0642\u0644\u0651 \u0643\u0627\u0646 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0648\u0641\u0642 \u0642\u0627\u0646\u0648\u0646 \u0641\u064a\u0643 \u0627\u0644\u0623\u0648\u0644 (Fickian diffusion)\u060c \u0623\u064a \u0623\u0646\u0651\u064e \u0622\u0644\u064a\u0629 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0647\u064a \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0636\u0628\u0637 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u0646 \u0646\u0638\u0627\u0645 \u0627\u0644\u0628\u0644\u0645\u0631 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 (n) \u062a\u062a\u0631\u0627\u0648\u062d \u0645\u0627 \u0628\u064a\u0646 0.45 &lt; n &lt; 0.89: \u0643\u0627\u0646 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0634\u0627\u0630\u0651 \u0623\u0648 \u0644\u0627 \u064a\u062a\u0628\u0639 \u0642\u0627\u0646\u0648\u0646 \u0641\u064a\u0643. \u0648\u064a\u0643\u0648\u0646 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0645\u0646 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u060c \u0623\u064a \u0623\u0646\u0651\u064e \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u064a\u0639\u062a\u0645\u062f \u0648\u0628\u0634\u0643\u0644\u064d \u0645\u064f\u0633\u062a\u0645\u0631\u0651 \u0639\u0644\u0649 \u0638\u0627\u0647\u0631\u0629 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0639\u0628\u0631 \u0627\u0644\u0628\u0644\u0645\u0631 \u0648\u0627\u0644\u0627\u0646\u062a\u0628\u0627\u062c \u0648\u0627\u0644\u062a\u0622\u0643\u0644 \u0644\u0644\u0628\u0644\u0645\u0631 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u2022 \u0648\u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 (n) \u0623\u0643\u0628\u0631 \u0623\u0648 \u062a\u0633\u0627\u0648\u064a 0.89 \u064a\u0643\u0648\u0646 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0648\u0641\u0642 \u0642\u0627\u0646\u0648\u0646 \u0641\u064a\u0643 \u0627\u0644\u062b\u0627\u0646\u064a\u060c \u0623\u064a \u0623\u0646\u0651\u064e \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u064a\u0643\u0648\u0646 \u0645\u0636\u0628\u0648\u0637\u0627\u064b \u0628\u0638\u0627\u0647\u0631\u0629 \u0627\u0646\u062a\u0628\u0627\u062c \u0627\u0644\u0628\u0644\u0645\u0631 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0641\u0642\u0637 [24]<strong>.<\/strong><\/span><\/p>\n<table width=\"0\">\n<tbody>\n<tr>\n<td colspan=\"2\" width=\"313\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (3): \u0645\u062a\u0637\u0644\u0628\u0627\u062a \u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a <\/strong><strong>USP38 \u2013 NF 33<\/strong><strong>\u00a0 \u0644\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0645\u062f\u064a\u062f\u0629.<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"172\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u062f\u0629 \u0627\u0644\u0632\u0651\u064e\u0645\u0646\u064a\u0629<\/strong><\/span><\/td>\n<td width=\"141\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0651\u0631\u0629 \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0626\u064a\u0651\u064e\u0629<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"172\"><span style=\"font-family: 'times new roman', times, serif;\">\u0631\u0628\u0639 \u0627\u0644\u0645\u062f\u0629 \u0627\u0644\u0632\u0651\u064e\u0645\u0646\u064a\u0629 (3 \u0633\u0627\u0639\u0627\u062a)<\/span><\/td>\n<td width=\"141\"><span style=\"font-family: 'times new roman', times, serif;\">\u0636\u0645\u0646 \u0645\u062c\u0627\u0644 15-35%<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"172\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0635\u0641 \u0627\u0644\u0645\u062f\u0629 \u0627\u0644\u0632\u0651\u064e\u0645\u0646\u064a\u0629 (6 \u0633\u0627\u0639\u0627\u062a)<\/span><\/td>\n<td width=\"141\"><span style=\"font-family: 'times new roman', times, serif;\">\u0636\u0645\u0646 \u0645\u062c\u0627\u0644 40-60%<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"172\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u062f\u0629 \u0627\u0644\u0632\u0651\u064e\u0645\u0646\u064a\u0629 (12 \u0633\u0627\u0639\u0629)<\/span><\/td>\n<td width=\"141\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0643\u0628\u0631 \u0645\u0646 85%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">3- \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u0651\u064e\u0629 \u0627\u0644\u0641\u0639\u0651\u064e\u0627\u0644\u0629 \u0648\u0627\u0644\u0633\u0651\u0648\u0627\u063a\u0627\u062a:<\/span><\/h3>\n<h4 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">7-1- \u0627\u0646\u0639\u0631\u0627\u062c \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 X-Ray diffraction:<\/span><\/h4>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645 \u062a\u062d\u0644\u064a\u0644 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 STOE Transmition Diffractometer System STADI P\u060c \u0627\u0644\u0645\u0632\u0648\u062f \u0628\u0640 [CuK\u03b1] \u0643\u0645\u0635\u062f\u0631 \u0644\u0623\u0634\u0639\u0629 X \u0630\u0627\u062a \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u03bb= 1.54 nm \u0648\u0645\u0648\u062d\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0645\u0646 \u0627\u0644\u062c\u0631\u0645\u0627\u0646\u064a\u0648\u0645. \u0643\u0627\u0646 \u0646\u0645\u0637 \u0627\u0644\u0645\u0633\u062d2\u03b8: \u03c9\u060c \u0648\u062a\u0631\u0627\u0648\u062d\u062a \u0642\u064a\u0645\u0629 \u0627\u0644\u0632\u0627\u0648\u064a\u0629 2\u03b8 \u0628\u064a\u0646 2-90\u00b0\u060c \u0628\u0645\u064f\u0639\u062f\u0651\u064e\u0644 \u0645\u0633\u062d 0.5\u00ba 2\u03b8\/min\u060c \u0648\u0630\u0644\u0643 \u0644\u0645\u0639\u0631\u0641\u0629 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0628\u0646\u064a\u0629 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0628\u0644\u0648\u0631\u064a\u0629 crystalline \u0623\u0648 \u0644\u0627 \u0628\u0644\u0648\u0631\u064a\u0629 amorphous.<\/span><\/p>\n<h4 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">7-2- \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 FTIR Spectroscopy:<\/span><\/h4>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u062c\u0631\u064a \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 BRUKER ALPHA FT-IR spectrum \u0636\u0645\u0646 \u0645\u062c\u0627\u0644 \u0627\u0644\u0623\u0639\u062f\u0627\u062f \u0627\u0644\u0645\u0648\u062c\u064a\u0629 wave number 4000 \u2013 400 \u0633\u0645<sup>-1<\/sup>\u060c \u0628\u0647\u062f\u0641 \u062a\u062d\u0631\u064a \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631\u0627\u062a \u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0628\u0646\u0633\u0628 1:1.<\/span><\/p>\n<h4 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">7-3- \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a Differential Scanning Calorimetry (DSC):<\/span><\/h4>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u062c\u0631\u064a \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 SETARAM DSC 131 \u0636\u0645\u0646 \u0645\u062c\u0627\u0644 \u062f\u0631\u062c\u0627\u062a \u062d\u0631\u0627\u0631\u0629 \u0645\u062a\u0632\u0627\u064a\u062f\u0629 \u0645\u0646 25 &#8211; 450\u00ba \u0645\u060c \u0628\u0645\u064f\u0639\u062f\u0651\u064e\u0644 10 \u062f\u0631\u062c\u0627\u062a \u0645\u0626\u0648\u064a\u0629\/\u062f\u0642\u064a\u0642\u0629\u060c \u0648\u062a\u062d\u062a \u062a\u062f\u0641\u0642 \u063a\u0627\u0632 \u0627\u0644\u0623\u0632\u0648\u062a N<sub>2<\/sub> \u0628\u0645\u064f\u0639\u062f\u0651\u064e\u0644 100 \u0645\u0644\/\u062f\u0642\u064a\u0642\u0629\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0648\u062a\u0642\u0629 \u0623\u0644\u0645\u0646\u064a\u0648\u0645 \u0628\u0633\u0639\u0629 30 \u0645\u064a\u0643\u0631\u0648 \u0644\u064a\u062a\u0631. \u0648\u0630\u0644\u0643 \u0628\u0648\u0632\u0646 \u0639\u064a\u0646\u0627\u062a 5 \u0645\u063a \u0628\u0647\u062f\u0641 \u062a\u062d\u0631\u064a \u0648\u062c\u0648\u062f \u062a\u0646\u0627\u0641\u0631\u0627\u062a \u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0628\u0646\u0633\u0628\u0629 1:1.<\/span><\/p>\n<h3 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">4-\u00a0\u00a0\u00a0\u00a0\u00a0 \u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u062a\u062c\u0627\u0631\u064a\u0629 \u0641\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0639 \u0623\u0641\u0636\u0644 \u0635\u064a\u063a\u0629 \u062a\u062d\u0631\u0651\u0631 \u0645\u062f\u064a\u062f:<\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645\u0651\u064e \u0625\u062c\u0631\u0627\u0621 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0639\u0644\u0649 6 \u0623\u0642\u0631\u0627\u0635 \u062a\u062c\u0627\u0631\u064a\u0629 \u0645\u062d\u0644\u064a\u0651\u0629 \u0641\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 ( \u00a0250 \u0645\u063a) \u0628\u0646\u0641\u0633 \u0634\u0631\u0648\u0637 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0645\u062f\u064a\u062f\u0629 \u0644\u0645\u062f\u0629 \u0633\u0627\u0639\u0629 \u0648\u0627\u062d\u062f\u0629\u060c \u0648\u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0644\u0623\u0641\u0636\u0644 \u0635\u064a\u063a\u0629 \u062a\u062d\u0631\u0651\u0631 \u0645\u062f\u064a\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Results and Discussion<\/strong><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 \u0648\u062a\u062d\u062f\u064a\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0648\u062d\u0638\u064e \u0639\u0646\u062f \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0633\u062d \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0641\u064a \u0648\u0633\u0637 \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 (0.07 N ) \u0648\u062c\u0648\u062f \u0642\u0645\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0623\u0639\u0638\u0645\u064a \u0646\u0648\u0639\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 (280 \u0646\u0627\u0646\u0648\u0645\u062a\u0631).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 1 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u062e\u0637\u064a\u0629 \u0627\u0644\u0637\u0631\u064a\u0642\u0629\u060c \u062d\u064a\u062b \u0643\u0627\u0646 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 R<sup>2<\/sup>=0.9992\u060c \u0623\u064a \u0623\u0646\u0651\u064e \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u062e\u0637\u064a\u0651\u064e\u0629.<\/span><\/p>\n<figure id=\"attachment_331\" aria-describedby=\"caption-attachment-331\" style=\"width: 387px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-331\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d1-300x221.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 1: \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644\" width=\"387\" height=\"285\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d1-300x221.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d1.png 413w\" sizes=\"auto, (max-width: 387px) 100vw, 387px\" \/><figcaption id=\"caption-attachment-331\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 1: \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644<\/span><\/strong><\/figcaption><\/figure>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0637\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0628\u0639\u062f \u0627\u0644\u0636\u063a\u0637:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0648\u0644 (4) \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0637\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0628\u0639\u062f \u0627\u0644\u0636\u063a\u0637\u060c \u0648\u0627\u0644\u062a\u064a \u0643\u0627\u0646\u062a \u062c\u0645\u064a\u0639\u0647\u0627 \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u0645\u0642\u0628\u0648\u0644\u0629.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635\u0648\u0635 \u0645\u064f\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0630\u0648\u0628\u0627\u0646 :<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633 \u0645\u0646\u062d\u0646\u064a \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u0629 \u062e\u0644\u0627\u0644 12 \u0633\u0627\u0639\u0629 \u0641\u064a \u0645\u062d\u0644\u0648\u0644 \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 (0.07 N ) \u0648\u0630\u064a (pH=1.15)\u060c \u064a\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 2 \u06483 \u0646\u062a\u0627\u0626\u062c \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0639\u0646\u062f \u0643\u0644 \u0627\u0644\u0646\u0642\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u064a \u0644\u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0635\u064a\u063a\u062a\u0627\u0646 F1 \u0648F2 \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u062a\u0627\u0646 \u0628\u0644\u0645\u0631 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0628\u062a\u0631\u0643\u064a\u0632 5% \u064810% \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a \u0623\u0628\u0637\u0623 \u0645\u0639\u062f\u0644\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644\u060c \u062d\u064a\u062b \u0644\u0645 \u064a\u062a\u062d\u0631\u0651\u064e\u0631 \u062e\u0644\u0627\u0644 12 \u0633\u0627\u0639\u0629 \u0633\u0648\u0649 \u062d\u0648\u0627\u0644\u064a 53% \u064835% \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0651\u064e\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629\u060c \u0648\u064a\u0639\u0632\u0649 \u0630\u0644\u0643 \u0625\u0644\u0649 \u0625\u0646\u0651\u064e \u0628\u0644\u0645\u0631 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0647\u0648 \u0628\u0644\u0645\u0631 \u0645\u062a\u0635\u0627\u0644\u0628 \u0630\u0648 \u0637\u0628\u064a\u0639\u0629 \u062d\u0645\u0636\u064a\u0629 (pKa=6) \u0628\u0633\u0628\u0628 \u0648\u062c\u0648\u062f \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0643\u0631\u0628\u0648\u0643\u0633\u064a\u0644\u064a\u0629 \u0641\u064a \u0628\u0646\u064a\u062a\u0647 [25]\u060c \u0644\u0630\u0644\u0643 \u0641\u0647\u0648 \u0644\u0627 \u064a\u062a\u0623\u064a\u0651\u0646 \u0641\u064a \u0648\u0633\u0637 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0627\u0644\u062d\u0645\u0636\u064a (pH= 1.15)\u060c \u0648\u0647\u0630\u0627 \u064a\u0642\u0644\u0644 \u0645\u0646 \u0625\u0645\u0627\u0647\u0629 \u0648\u0627\u0646\u062a\u0628\u0627\u062c \u0627\u0644\u0628\u0644\u0645\u0631\u060c \u0648\u064a\u0635\u0639\u0651\u0628 \u062a\u062d\u0631\u0651\u0631 \u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062d\u062a\u062c\u0632\u0629 \u0628\u064a\u0646 \u0633\u0644\u0627\u0633\u0644\u0647 \u0627\u0644\u0645\u062a\u0635\u0627\u0644\u0628\u0629\u060c \u0648\u062a\u062a\u0641\u0642 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 Suma \u0648\u0632\u0645\u0644\u0627\u0626\u0647 [26].<\/span><\/p>\n<table width=\"0\">\n<tbody>\n<tr>\n<td colspan=\"7\" width=\"614\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (4): \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0637\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0628\u0639\u062f \u0627\u0644\u0636\u063a\u0637<\/strong><\/span><\/td>\n<td width=\"3\"><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0635\u064a\u063a<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0647\u0634\u0627\u0634\u0629%<\/strong><\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0633\u0645\u0627\u0643\u0629 (\u0645\u0644\u0645)<br \/>\n<\/strong><strong>SD\u00b1<\/strong><\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0642\u0633\u0627\u0648\u0629 (\u0643\u063a\/\u0633\u0645<sup>2<\/sup>)<br \/>\n<\/strong><strong>SD\u00b1<\/strong><\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0642\u0637\u0631 (\u0645\u0644\u0645)<br \/>\n<\/strong><strong>SD\u00b1<\/strong><\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0648\u0633\u0637\u064a\u0651 (\u0645\u0644\u063a)\u00a0 <\/strong><strong>\u00a0SD\u00b1<\/strong><\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649%<br \/>\n<\/strong><strong>SD\u00b1<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F1<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.31<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.7\u00b10.027<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.32\u00b10.47<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.5\u00b10.017<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>294.2\u00b13.12<\/strong><\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">96.4<strong>\u00b1<\/strong>1.58<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F2<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.26<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.72\u00b10.033<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.56\u00b10.59<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.49\u00b10.022<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">296.7\u00b13.81<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">98.3\u00b11.15<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F3<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.23<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.73\u00b10.019<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.63\u00b10.46<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.48\u00b10.022<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>307.<\/strong><strong>5<\/strong><strong>\u00b12.63<\/strong><\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">97.7\u00b12.10<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F4<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.34<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.75\u00b10.024<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.76\u00b10.016<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.47\u00b10.019<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">302.9\u00b13.54<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">99.3\u00b11.67<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F5<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.52<\/strong><\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.74\u00b10.028<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">6.52\u00b10.68<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.47\u00b10.015<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">297.7\u00b13.70<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">101.2\u00b11.77<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F6<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.42<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.75\u00b10.029<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">6.86\u00b10.42<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.47\u00b10.018<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">296.4\u00b12.42<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">98.4\u00b12.03<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F7<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.47<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>3.68\u00b10.033<\/strong><\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>6.47\u00b10.51<\/strong><\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.51\u00b10.017<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">298.6\u00b13.98<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">97.1\u00b11.81<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F8<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.36<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.69\u00b10.027<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.72\u00b10.4<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>11.52\u00b10.021<\/strong><\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">304.1\u00b13.12<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">102.3\u00b11.31<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F9<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.23<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.77\u00b10.025<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.81\u00b10.38<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.5\u00b10.019<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">297.3\u00b12.54<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>102.8\u00b12.29<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F10<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.11<\/strong><\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.78\u00b10.018<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>7.98\u00b10.32<\/strong><\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.48\u00b10.018<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">303.5\u00b12.43<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">101.7\u00b11.91<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F11<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.34<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.8\u00b10.041<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.33\u00b10.71<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.47\u00b10.017<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">298.1 \u00b12.63<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>95.5\u00b11.63<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F12<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.23<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>3.82\u00b10.037<\/strong><\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.53\u00b10.34<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>11.46\u00b10.017<\/strong><\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">297.8\u00b13.91<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">97.4\u00b12.32<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F13<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.33<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.73\u00b10.027<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.40\u00b10.19<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.49\u00b10.024<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">298.7\u00b13.68<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">102.6\u00b11.87<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>F14<\/strong><\/span><\/td>\n<td width=\"66\"><span style=\"font-family: 'times new roman', times, serif;\">0.25<\/span><\/td>\n<td width=\"104\"><span style=\"font-family: 'times new roman', times, serif;\">3.74\u00b10.016<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">7.27\u00b10.51<\/span><\/td>\n<td width=\"94\"><span style=\"font-family: 'times new roman', times, serif;\">11.48\u00b10.017<\/span><\/td>\n<td width=\"95\"><span style=\"font-family: 'times new roman', times, serif;\">302.4\u00b12.12<\/span><\/td>\n<td colspan=\"2\" width=\"98\"><span style=\"font-family: 'times new roman', times, serif;\">98.6\u00b12.37<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<figure id=\"attachment_335\" aria-describedby=\"caption-attachment-335\" style=\"width: 489px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-335\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d2-300x143.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (2): \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0635\u064a\u063a F1-F8\" width=\"489\" height=\"233\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d2-300x143.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d2-768x366.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d2.png 855w\" sizes=\"auto, (max-width: 489px) 100vw, 489px\" \/><figcaption id=\"caption-attachment-335\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 (2): \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0635\u064a\u063a F1-F8<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_336\" aria-describedby=\"caption-attachment-336\" style=\"width: 484px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-336\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d3-300x151.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (3): \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0635\u064a\u063a F9-F14\" width=\"484\" height=\"244\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d3-300x151.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d3-768x387.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d3.png 850w\" sizes=\"auto, (max-width: 484px) 100vw, 484px\" \/><figcaption id=\"caption-attachment-336\" class=\"wp-caption-text\"><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\"><strong>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 (3): \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0635\u064a\u063a F9-F14<\/strong><\/span><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0635\u064a\u063a\u062a\u0627\u0646 F3 \u0648F4 \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u062a\u0627\u0646 \u0639\u0644\u0649 \u0628\u0644\u0645\u0631 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646 \u0628\u062a\u0631\u0627\u0643\u064a\u0632 15% \u064820% \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a \u0623\u0633\u0631\u0639 \u0645\u0639\u062f\u0644\u0627\u062a \u062a\u062d\u0631\u0631 \u062d\u064a\u062b \u062a\u062d\u0631\u0651\u0631 100% \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0651\u064e\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u062e\u0644\u0627\u0644 4 \u0633\u0627\u0639\u0627\u062a \u06485 \u0633\u0627\u0639\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u064a\u064f\u0639\u0632\u064e\u0649 \u0630\u0644\u0643 \u0625\u0644\u0649 \u0627\u062d\u062a\u0648\u0627\u0621 \u0628\u0644\u0645\u0631 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646 \u0641\u064a \u0628\u0646\u064a\u062a\u0647 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0623\u0645\u064a\u0646\u064a\u0629 \u062a\u062a\u0623\u064a\u0646 \u0641\u064a \u0648\u0633\u0637 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0627\u0644\u062d\u0645\u0636\u064a \u0644\u064a\u0643\u062a\u0633\u0628 \u0634\u062d\u0646\u0629 \u0645\u0648\u062c\u0628\u0629 [27]\u060c \u064a\u0632\u064a\u062f \u0647\u0630\u0627 \u0627\u0644\u062a\u0623\u064a\u0651\u0646 \u0627\u0646\u062d\u0644\u0627\u0644\u064a\u0629 \u0627\u0644\u0628\u0644\u0645\u0631 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0648\u064a\u062f\u0641\u0639 \u0633\u0644\u0627\u0633\u0644 \u0627\u0644\u0628\u0644\u0645\u0631 \u0644\u0644\u062a\u0646\u0627\u0641\u0631 \u0628\u0639\u064a\u062f\u0627\u064b \u0639\u0646 \u0628\u0639\u0636\u0647\u0627\u060c \u0645\u0645\u0651\u064e\u0627 \u064a\u0632\u064a\u062f \u0645\u0646 \u062a\u0645\u064a\u0651\u0647 \u0648\u0627\u0646\u062a\u0628\u0627\u062c \u0627\u0644\u0628\u0644\u0645\u0631 \u0648\u064a\u0633\u0631\u0651\u0639 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0645\u0627\u062f\u0651\u064e\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629\u060c \u0648\u0647\u0630\u0627 \u064a\u062a\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 Souza \u0648\u0632\u0645\u0644\u0627\u0626\u0647 [28]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0639\u062a\u0645\u062f \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0641\u064a \u0627\u0644\u0635\u064a\u063a F5-F8 \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u0629 \u0639\u0644\u0649 \u0628\u0644\u0645\u0631 HPMC \u0628\u0646\u0648\u0639\u064a\u0647 \u0639\u0644\u0649 \u0644\u0632\u0648\u062c\u0629 \u0627\u0644\u0628\u0644\u0645\u0631 \u0648\u062a\u0631\u0643\u064a\u0632\u0647\u060c \u062d\u064a\u062b \u0623\u0646\u0651\u064e \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0648\u0627\u0644\u0644\u0632\u0648\u062c\u0629 \u0623\u062f\u064e\u0649 \u0625\u0644\u0649 \u0625\u0628\u0637\u0627\u0621 \u0645\u0639\u062f\u0644 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631\u060c \u0648\u0647\u0630\u0627 \u064a\u062a\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 Rao \u00a0\u0648\u0632\u0645\u0644\u0627\u0626\u0647 [12]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0625\u0646\u0651\u064e \u0645\u0634\u0627\u0631\u0643\u0629 \u0628\u0644\u0645\u0631 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0645\u0639 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u063a\u064a\u0651\u064e\u0631 \u0645\u0631\u062a\u0633\u0645\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0645\u0631\u062a\u0633\u0645\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0628\u0634\u0643\u0644 \u0645\u0641\u0631\u062f\u060c \u0648\u0623\u062f\u0651\u064e\u0649 \u0625\u0644\u0649 \u0625\u0628\u0637\u0627\u0621 \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631. \u0645\u0646 \u0628\u064a\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u062d\u0631\u0651\u064e\u0631\u062a \u0627\u0644\u0635\u064a\u063a\u062a\u0627\u0646 F10,F11 \u062d\u0648\u0627\u0644\u064a 100% \u0645\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u062e\u0644\u0627\u0644 \u0632\u0645\u0646 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0627\u0644\u0643\u0644\u0651\u064a 12 \u0633\u0627\u0639\u0629\u060c \u0648\u064a\u0639\u0632\u0649 \u0630\u0644\u0643 \u0625\u0644\u0649 \u0627\u0632\u062f\u064a\u0627\u062f \u0627\u0646\u062a\u0628\u0627\u062c \u0627\u0644\u0634\u0651\u064e\u0643\u0644 \u0627\u0644\u062c\u0631\u0639\u064a \u0648\u0644\u0632\u0648\u062c\u062a\u0647 \u0641\u064a \u0648\u0633\u0637 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u060c \u0648\u0648\u062c\u0648\u062f \u0627\u0644\u0631\u0648\u0627\u0628\u0637 \u0627\u0644\u0645\u062a\u0635\u0627\u0644\u0628\u0629 \u0628\u064a\u0646 \u0633\u0644\u0627\u0633\u0644 \u0628\u0644\u0645\u0631 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0648\u0627\u0644\u0630\u064a \u0633\u0627\u0647\u0645 \u0641\u064a \u0636\u0628\u0637 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631. \u064a\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 (4) \u0642\u0631\u0635 \u0627\u0644\u0635\u064a\u063a\u0629 F10 \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u0629 \u0639\u0644\u0649 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646 \u0628\u062a\u0631\u0643\u064a\u0632 5% \u0648\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0628\u062a\u0631\u0643\u064a\u0632 10% \u0639\u0644\u0649 \u0627\u0644\u064a\u0645\u064a\u0646 \u0628\u0639\u062f \u0627\u0646\u062a\u0647\u0627\u0621 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u060c \u0648\u0639\u0644\u0649 \u0627\u0644\u064a\u0633\u0627\u0631 \u0642\u0631\u0635 \u0627\u0644\u0635\u064a\u063a\u0629 F11 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0628\u0644\u0645\u0631 HPMC K4M \u0628\u062a\u0631\u0643\u064a\u0632 15% \u0648\u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0628\u062a\u0631\u0643\u064a\u0632 5%. <\/span><\/p>\n<figure id=\"attachment_338\" aria-describedby=\"caption-attachment-338\" style=\"width: 567px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-338\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d4-300x130.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (4): \u0639\u0644\u0649 \u0627\u0644\u064a\u0645\u064a\u0646 \u0634\u0643\u0644 \u0642\u0631\u0635 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 F10\u060c \u0648\u0639\u0644\u0649 \u0627\u0644\u064a\u0633\u0627\u0631 \u0634\u0643\u0644 \u0645\u0646 \u0642\u0631\u0635 \u0627\u0644\u0635\u064a\u063a\u0629 F11 \u0639\u0646\u062f \u0646\u0647\u0627\u064a\u0629 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 (12\u0633\u0627\u0639\u0629)\" width=\"567\" height=\"246\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d4-300x130.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d4.png 659w\" sizes=\"auto, (max-width: 567px) 100vw, 567px\" \/><figcaption id=\"caption-attachment-338\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u0627\u0644\u0634\u0643\u0644 (4): \u0639\u0644\u0649 \u0627\u0644\u064a\u0645\u064a\u0646 \u0634\u0643\u0644 \u0642\u0631\u0635 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 F10\u060c \u0648\u0639\u0644\u0649 \u0627\u0644\u064a\u0633\u0627\u0631 \u0634\u0643\u0644 \u0645\u0646 \u0642\u0631\u0635 \u0627\u0644\u0635\u064a\u063a\u0629 F11 \u0639\u0646\u062f \u0646\u0647\u0627\u064a\u0629 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 (12\u0633\u0627\u0639\u0629)<\/span><\/strong><\/figcaption><\/figure>\n<h2 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>1-<\/strong><strong>\u0646\u062a\u0627\u0626\u062c \u062a\u0648\u0641\u0642 \u0646\u0633\u0628 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0645\u0639 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629:<\/strong><\/span><\/h2>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u0642\u0642\u062a \u0627\u0644\u0635\u064a\u063a\u0629 F11 (HPMC K4M \u0628\u062a\u0631\u0643\u064a\u0632 15% \u0648\u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0628\u062a\u0631\u0643\u064a\u0632 5% ) \u0645\u062a\u0637\u0644\u0628\u0627\u062a USP38\u2013NF 33 \u0644\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0645\u062f\u064a\u062f\u0629 \u062e\u0644\u0627\u0644 12 \u0633\u0627\u0639\u0629 \u0639\u0646\u062f \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u062b\u0644\u0627\u062b \u0627\u0644\u0645\u062d\u062f\u062f\u0629\u060c \u064a\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (5) \u0646\u0633\u0628 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0639\u0646\u062f \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u062f\u0633\u062a\u0648\u0631\u064a\u0627\u064b\u060c \u0648\u0641\u064a\u0645\u0627 \u0625\u0630\u0627 \u062d\u0642\u064e\u0651\u0642\u062a \u0646\u0633\u0628 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0645\u062a\u0637\u0644\u0628\u0627\u062a \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062f\u0631\u0627\u0633\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c: <\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0639\u062f \u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0621 \u0645\u0646 \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629\u060c \u062f\u064f\u0631\u0633\u062a \u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0628\u0648\u0627\u0633\u0637\u0629 \u0628\u0631\u0646\u0627\u0645\u062c Microsoft Excel 2007\u060c \u0648\u062d\u064f\u0633\u0628\u062a \u0642\u064a\u0645 R2 \u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0622\u062a\u064a\u0629: Zero-order\u060c First-order\u060c Higuchi\u060c Hixson-Crowell\u060c Korsmeyer- Peppas \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0630\u064a \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0646\u0645\u0637 \u062a\u062d\u0631\u0651\u0631 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0646 \u0643\u0644\u0651 \u0635\u064a\u063a\u0629. \u064a\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (6) \u0646\u062a\u0627\u0626\u062c \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u060c \u0648\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u0648\u0627\u0641\u0642.<\/span><\/p>\n<table width=\"0\">\n<tbody>\n<tr>\n<td colspan=\"6\" width=\"649\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (5): \u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0651\u0631\u0629 \u0639\u0646\u062f \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u062f\u0633\u062a\u0648\u0631\u064a\u0627\u064b<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0635\u064a\u063a\u0629<\/strong><\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0632\u0645\u0646 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0645\u0637\u0644\u0648\u0628<br \/>\n(\u0633\u0627\u0639\u0629)<\/strong><\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>(3 \u0633\u0627\u0639\u0627\u062a)<\/strong><\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>(6 \u0633\u0627\u0639\u0627\u062a)<\/strong><\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>(12 \u0633\u0627\u0639\u0629)<\/strong><\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0627\u0644\u062f\u0633\u062a\u0648\u0631<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F1<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">26.9%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">38.7%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">52.8%<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 6<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F2<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">17.8%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">26.7%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">35.7%<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 6<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F3<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">87.2%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F4<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">76.2%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F5<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">63.3%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">96.5%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F6<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">55.7%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">77.8%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F7<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">48.2%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">69.5%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F8<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">33.8%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">48.6%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">67.4%<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 12<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F9<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">53.7%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">78.9%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">&#8211;<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F10<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">41.6%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">64.8%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">97.2%<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F11<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>34.2%<\/strong><\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>58.7%<\/strong><\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>98.9%<\/strong><\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0648\u0627\u0641\u0642\u0629<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F12<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">27.5%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">45.6%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">78.3%<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 12<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F13<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">36.6%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">52.3%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">78.1%<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 3<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"67\"><span style=\"font-family: 'times new roman', times, serif;\">F14<\/span><\/td>\n<td width=\"116\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">26.8%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">43.6%<\/span><\/td>\n<td width=\"84\"><span style=\"font-family: 'times new roman', times, serif;\">55.4%<\/span><\/td>\n<td width=\"213\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u064a\u0631 \u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0646\u062f \u0627\u0644\u0633\u0627\u0639\u0629 12<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 67.8%; height: 1086px;\" width=\"0\">\n<tbody>\n<tr>\n<td colspan=\"7\" width=\"600\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (6): \u0646\u062a\u0627\u0626\u062c \u062a\u062d\u0631\u0631 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629\u060c \u0648\u0646\u0645\u0627\u0630\u062c \u0627\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0635\u064a\u063a<\/span><\/td>\n<td colspan=\"2\" width=\"189\"><span style=\"font-family: 'times new roman', times, serif;\">Korsmeyer-Peppas<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">Hixon-Crowell<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">Higuchi<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">First-Order<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">Zero-Order<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">n<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">R\u00b2<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">R\u00b2<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">R\u00b2<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">R\u00b2<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">R\u00b2<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F1<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.499<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.998<\/strong><\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.895<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">0.998<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.986<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.958<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F2<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.4994<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.998<\/strong><\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.875<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">0.997<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.968<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.948<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F3<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.667<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.98<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.898<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.994<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.886<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.963<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F4<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.504<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.986<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.919<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.992<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.848<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.966<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F5<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.657<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.992<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.969<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.996<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.866<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.975<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F6<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.502<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.991<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.87<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.996<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.753<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.954<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F7<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.59<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.999<\/strong><\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.899<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">0.997<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.861<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.975<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F8<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.554<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.996<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.869<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.997<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.993<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.954<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F9<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.541<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.995<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.874<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.998<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.868<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.957<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F10<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.591<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.997<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.899<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.997<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.897<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.977<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F11<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.665<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.991<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.945<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">0.977<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.777<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.997<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F12<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.616<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.99<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.949<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">0.978<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.977<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.996<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F13<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.596<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\">0.996<\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.868<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.998<\/strong><\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.993<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.962<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"76\"><span style=\"font-family: 'times new roman', times, serif;\">F14<\/span><\/td>\n<td width=\"125\"><span style=\"font-family: 'times new roman', times, serif;\">0.604<\/span><\/td>\n<td width=\"64\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>0.991<\/strong><\/span><\/td>\n<td width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\">0.842<\/span><\/td>\n<td width=\"92\"><span style=\"font-family: 'times new roman', times, serif;\">0.989<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.968<\/span><\/td>\n<td width=\"79\"><span style=\"font-family: 'times new roman', times, serif;\">0.931<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0644\u0627\u062d\u0638 \u0645\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (6) \u0623\u0646\u0651\u064e \u0627\u0644\u0635\u064a\u063a F1 \u0648F2 \u0648F7 \u0648F14 \u0642\u062f \u062a\u0648\u0627\u0641\u0642\u062a \u0623\u0646\u0645\u0627\u0637 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646\u0647\u0627 \u0645\u0639 Korsmeyer Peppas \u062d\u064e\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645 R<sup>2<\/sup> \u0647\u064a \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0623\u062e\u0631\u0649\u060c \u0648\u0643\u0627\u0646\u062a \u0642\u064a\u0645 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u062a\u0651\u064e\u062d\u0631\u0651\u0631 \u0627\u0644\u0623\u0633\u064a (n) \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 F1 \u0648F2 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a 0.499 \u0648 0.4994\u060c \u0641\u064a \u062d\u064a\u0646 \u0643\u0627\u0646\u062a \u0642\u064a\u0645 n \u062a\u0633\u0627\u0648\u064a 0.59 \u06480.604 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 F7 \u0648F14 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a\u060c \u0648\u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645 \u0628\u064a\u0646 0.45 \u06480.89\u060c \u0648\u0647\u0630\u0627 \u064a\u062f\u0644\u0651 \u0639\u0644\u0649 \u0623\u0646\u0651\u064e \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0634\u0627\u0630\u0651 \u0648\u0644\u0627 \u064a\u062a\u0628\u0639 \u0642\u0627\u0646\u0648\u0646 \u0641\u064a\u0643 \u0627\u0644\u0623\u0648\u0644 \u0641\u064a \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631\u060c \u0648\u062a\u062d\u0631\u0651\u064e\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0638\u0627\u0647\u0631\u062a\u064a \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0646\u062a\u0628\u0627\u062c \u0627\u0644\u0628\u0644\u0645\u0631 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u00a0\u0625\u0646\u0651\u064e \u0627\u0644\u0635\u064a\u063a F3 \u0648F4 \u0648F5 \u0648F6 \u0648F8 \u0648F9 \u0648F10 \u0648F13 \u0642\u062f \u0623\u0639\u0637\u062a \u062a\u062d\u0631\u0651\u0631 \u0645\u0646 \u0646\u0645\u0637 Higuchi \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645 R<sup>2<\/sup> \u0647\u064a \u0627\u0644\u0623\u0639\u0644\u0649\u060c \u0623\u064a \u0623\u0646\u0651\u064e \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0642\u0627\u0644\u0628 \u064a\u062a\u0646\u0627\u0633\u0628 \u0645\u0639 \u0627\u0644\u062c\u0630\u0631 \u0627\u0644\u062a\u0631\u0628\u064a\u0639\u064a \u0644\u0644\u0632\u0645\u0646\u060c \u0643\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646\u0651\u064e \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0647\u064a \u0627\u0644\u0622\u0644\u064a\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u062a\u062d\u0631\u0631. \u0625\u0646\u0651\u064e \u0627\u0644\u0635\u064a\u063a F11 \u0648F12 \u062a\u0648\u0627\u0641\u0642\u062a \u0645\u0639 \u062a\u062d\u0631\u0651\u0631 \u0645\u0646 \u0646\u0645\u0637 Zero Order \u0648\u0647\u064a \u0627\u0644\u0631\u0651\u062a\u0628\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u062f\u0629 \u0644\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0645\u062f\u064a\u062f\u0629\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645 R<sup>2<\/sup> \u0647\u064a \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0623\u062e\u0631\u0649. \u0625\u0646\u0651\u064e \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0645\u0646 \u0627\u0644\u0631\u062a\u0628\u0629 Zero Order \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646\u0651\u064e \u0633\u0631\u0639\u0629 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0642\u0627\u0644\u0628 \u062b\u0627\u0628\u062a\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0632\u0645\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>5-1\u00a0\u00a0\u00a0\u00a0 \u0646\u062a\u0627\u0626\u062c \u0627\u0646\u0639\u0631\u0627\u062c \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 <\/strong><strong>X-Ray diffraction<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 5 \u0645\u062e\u0637\u0637 \u0627\u0646\u0639\u0631\u0627\u062c \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 \u0644\u0645\u0627\u062f\u0629 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0623\u0646\u0651\u064e\u0647\u0627 \u0639\u062f\u064a\u0645\u0629 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u064a \u0645\u0639 \u0648\u062c\u0648\u062f \u0622\u062b\u0627\u0631 \u0628\u0646\u064a\u0629 \u0628\u0644\u0648\u0631\u064a\u0629 [29,30].<\/span><\/p>\n<figure id=\"attachment_340\" aria-describedby=\"caption-attachment-340\" style=\"width: 436px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-340\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d5-300x190.png\" alt=\"\u0627\u0644\u0634\u0651\u0643\u0644 (5): \u0645\u062e\u0637\u0637 \u0627\u0646\u0639\u0631\u0627\u062c \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 \u0644\u0645\u0627\u062f\u0629 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644\" width=\"436\" height=\"276\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d5-300x190.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d5-768x486.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d5.png 862w\" sizes=\"auto, (max-width: 436px) 100vw, 436px\" \/><figcaption id=\"caption-attachment-340\" class=\"wp-caption-text\"><strong><span style=\"font-size: 10pt; font-family: 'times new roman', times, serif;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0651\u0643\u0644 (5): \u0645\u062e\u0637\u0637 \u0627\u0646\u0639\u0631\u0627\u062c \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 \u0644\u0645\u0627\u062f\u0629 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>-2- \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 <\/strong><strong>FTIR Spectroscopy<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0627\u0643\u0633\u064a\u062a\u064a\u0644 \u0623\u0647\u0645 \u0627\u0645\u062a\u0637\u0627\u0637\u0627\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0644\u0645\u0627\u062f\u0629\u00a0 \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0628\u0627\u0644\u0634\u0643\u0644 (6) \u0648\u0627\u0644\u062c\u062f\u0648\u0644 (7) [31].<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646 \u0648 HPMCK4M \u0648 HPMCK15 \u0623\u0646 \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0648\u0635\u0641\u064a\u0629 \u0644\u0644\u0645\u0632\u0627\u0626\u062c \u0643\u0627\u0646\u062a \u0645\u0634\u0627\u0628\u0647\u0629 \u0644\u062a\u0644\u0643 \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0627\u0644\u0646\u0642\u064a \u0645\u0645\u0627 \u0642\u062f \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0648 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934P \u0627\u062e\u062a\u0641\u0627\u0621 \u0628\u0639\u0636 \u0627\u0645\u062a\u0637\u0627\u0637\u0627\u062a \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0648\u0635\u0641\u064a\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0645\u0627 \u0642\u062f \u064a\u0634\u064a\u0631 \u0627\u0644\u0649 \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631 \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0648HPMCK4M \u0623\u0646\u0651\u064e \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0648\u0635\u0641\u064a\u0629 \u0644\u0644\u0645\u0632\u064a\u062c \u0643\u0627\u0646\u062a \u0645\u0634\u0627\u0628\u0647\u0629 \u0644\u062a\u0644\u0643 \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0627\u0644\u0646\u0642\u064a \u0645\u0645\u0627 \u0642\u062f \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629.<\/span><\/p>\n<figure id=\"attachment_264\" aria-describedby=\"caption-attachment-264\" style=\"width: 520px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-264\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/Capture-3-300x150.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (6): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644\" width=\"520\" height=\"260\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/Capture-3-300x150.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/Capture-3.png 692w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><figcaption id=\"caption-attachment-264\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 (6): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644<\/span><\/strong><\/figcaption><\/figure>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\" width=\"503\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644<\/strong><strong>\u062c\u062f\u0648\u0644 (7): \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0648\u0635\u0641\u064a\u0629 \u0644\u0645\u0627\u062f\u0629 \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621.<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629<\/strong><\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0639\u062f\u062f \u0627\u0644\u0645\u0648\u062c\u064a (<\/strong><strong>cm<sup>-1<\/sup><\/strong><strong>)<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\">C=O Beta Lactam<\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\">1725<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\">C=O Amide<\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\">1690<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\">-OCONH2 Carbamate<\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\">1537<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\">C-N Beta Lactam<\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\">1375<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\">-C-O-C Ether<\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\">1210<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\">C-N Side Chain<\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\">1040<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><span style=\"font-family: 'times new roman', times, serif;\">C-S Beta Lactam<\/span><\/td>\n<td width=\"191\"><span style=\"font-family: 'times new roman', times, serif;\">751<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<figure id=\"attachment_345\" aria-describedby=\"caption-attachment-345\" style=\"width: 469px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-345\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d7-300x169.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (7): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646\" width=\"469\" height=\"264\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d7-300x169.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d7-1024x576.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d7-768x432.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d7.png 1366w\" sizes=\"auto, (max-width: 469px) 100vw, 469px\" \/><figcaption id=\"caption-attachment-345\" class=\"wp-caption-text\"><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\"><strong>\u00a0 \u0627\u0644\u0634\u0643\u0644 (7): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646<\/strong><\/span><\/figcaption><\/figure>\n<figure id=\"attachment_346\" aria-describedby=\"caption-attachment-346\" style=\"width: 431px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-346\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d8-300x169.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (8): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 p934\" width=\"431\" height=\"243\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d8-300x169.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d8-1024x576.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d8-768x432.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d8.png 1366w\" sizes=\"auto, (max-width: 431px) 100vw, 431px\" \/><figcaption id=\"caption-attachment-346\" class=\"wp-caption-text\"><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\"><strong>\u0627\u0644\u0634\u0643\u0644 (8): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 p934<\/strong><\/span><\/figcaption><\/figure>\n<figure id=\"attachment_348\" aria-describedby=\"caption-attachment-348\" style=\"width: 428px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-348\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d9-300x169.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (9): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 HPMC K4M\" width=\"428\" height=\"241\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d9-300x169.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d9-1024x576.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d9-768x432.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d9.png 1366w\" sizes=\"auto, (max-width: 428px) 100vw, 428px\" \/><figcaption id=\"caption-attachment-348\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u0627\u0644\u0634\u0643\u0644 (9): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 HPMC K4M<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_349\" aria-describedby=\"caption-attachment-349\" style=\"width: 430px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-349\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d10-300x169.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (10): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 HPMC K15M\" width=\"430\" height=\"242\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d10-300x169.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d10-1024x576.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d10-768x432.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d10.png 1366w\" sizes=\"auto, (max-width: 430px) 100vw, 430px\" \/><figcaption id=\"caption-attachment-349\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u0627\u0644\u0634\u0643\u0644 (10): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 HPMC K15<\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">M<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_350\" aria-describedby=\"caption-attachment-350\" style=\"width: 426px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-350\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d11-300x169.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 (11): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 Carbopol 934P \u0648HPMC K4M.\" width=\"426\" height=\"240\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d11-300x169.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d11-1024x576.jpg 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d11-768x432.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d11.jpg 1280w\" sizes=\"auto, (max-width: 426px) 100vw, 426px\" \/><figcaption id=\"caption-attachment-350\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u0627\u0644\u0634\u0643\u0644 (11): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064e\u0651\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0633\u064a\u062a\u064a\u0644 \u0648\u0645\u0632\u064a\u062c\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0645\u0639 Carbopol 934P \u0648HPMC K4M<\/span><\/strong><\/figcaption><\/figure>\n<h3 style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">5-3-\u00a0\u00a0\u00a0\u00a0\u00a0 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a DSC:<\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 (12) \u0648\u062c\u0648\u062f \u0642\u0645\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u062a\u0635\u0644 \u0630\u0631\u0648\u062a\u0647\u0627 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u00b087.59\u060c \u0648\u0647\u064a \u062a\u0639\u0628\u0631 \u0639\u0646 \u062f\u0631\u062c\u0629 \u0627\u0644\u062a\u062d\u0648\u0644 \u0627\u0644\u0632\u062c\u0627\u062c\u064a \u0644\u0644\u0642\u0633\u0645 \u0627\u0644\u0644\u0627\u0628\u0644\u0648\u0631\u064a \u0645\u0646 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644. \u0643\u0645\u0627 \u0646\u0644\u0627\u062d\u0638 \u0648\u062c\u0648\u062f \u0642\u0645\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u062a\u0635\u0644 \u0630\u0631\u0648\u062a\u0647\u0627 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u00b0175.8 \u0648\u0647\u064a \u062a\u0639\u0628\u0631 \u0639\u0646 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0628\u0644\u0648\u0631\u064a \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 [32]. \u0646\u0644\u0627\u062d\u0638 \u0623\u064a\u0636\u0627\u064b \u0648\u062c\u0648\u062f \u0642\u0645\u0629 \u0639\u0631\u064a\u0636\u0629 \u0646\u0627\u0634\u0631\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u062a\u0635\u0644 \u0630\u0631\u0648\u062a\u0647\u0627 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u00b0238.95 \u0648\u0647\u064a \u062a\u0639\u0628\u0631 \u0639\u0646 \u062a\u062e\u0631\u0628 \u0648\u062a\u0641\u0643\u0643 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629.[29]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0644\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646 \u0648 HPMC K4M \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0646\u0642\u064a\u0629 \u0627\u0646\u0632\u064a\u0627\u062d\u0627\u062a \u0628\u0633\u064a\u0637\u0629 \u0641\u064a \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u0645\u0645\u0627 \u0642\u062f \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0644\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0648 HPMC K15M \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0646\u0642\u064a\u0629 \u0648\u062c\u0648\u062f \u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0648\u0627\u0636\u062d\u0629 \u0645\u0645\u0627 \u0642\u062f \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631\u0627\u062a \u062a\u0639\u0632\u0649 \u0625\u0644\u0649 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u062c\u0632\u064a\u0626\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0645\u062e\u0637\u0637 \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p \u0648 HPMC K4M \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0646\u0642\u064a\u0629 \u0627\u0646\u0632\u064a\u0627\u062d\u0627\u062a \u0628\u0633\u064a\u0637\u0629 \u0641\u064a \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0639\u0627\u0626\u062f\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u0645\u0645\u0627 \u0642\u062f \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0648\u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629.<\/span><\/p>\n<figure id=\"attachment_351\" aria-describedby=\"caption-attachment-351\" style=\"width: 590px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-351\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d12-300x123.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (12): \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644\" width=\"590\" height=\"242\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d12-300x123.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d12-768x315.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d12.png 800w\" sizes=\"auto, (max-width: 590px) 100vw, 590px\" \/><figcaption id=\"caption-attachment-351\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 (12): \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_352\" aria-describedby=\"caption-attachment-352\" style=\"width: 589px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-352\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d13-300x225.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 (13): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 HPMC K15M\" width=\"589\" height=\"442\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d13-300x225.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d13-768x576.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d13.jpg 1024w\" sizes=\"auto, (max-width: 589px) 100vw, 589px\" \/><figcaption id=\"caption-attachment-352\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 (13): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 HPMC K15M<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_353\" aria-describedby=\"caption-attachment-353\" style=\"width: 572px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-353\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d14-300x225.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 (14): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 HPMC K4M\" width=\"572\" height=\"429\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d14-300x225.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d14-768x576.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d14.jpg 1024w\" sizes=\"auto, (max-width: 572px) 100vw, 572px\" \/><figcaption id=\"caption-attachment-353\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u0627\u0644\u0634\u0643\u0644 (14): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 HPMC K4M<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_354\" aria-describedby=\"caption-attachment-354\" style=\"width: 578px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-354\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d15-300x225.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 (15): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646\" width=\"578\" height=\"433\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d15-300x225.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d15-768x576.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d15.jpg 1024w\" sizes=\"auto, (max-width: 578px) 100vw, 578px\" \/><figcaption id=\"caption-attachment-354\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 (15): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0634\u064a\u062a\u0648\u0632\u0627\u0646<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_355\" aria-describedby=\"caption-attachment-355\" style=\"width: 587px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-355\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d16-300x225.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 (16): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0648Carbopol 934p\" width=\"587\" height=\"441\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d16-300x225.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d16-768x576.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d16.jpg 1024w\" sizes=\"auto, (max-width: 587px) 100vw, 587px\" \/><figcaption id=\"caption-attachment-355\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u0627\u0644\u0634\u0643\u0644 (16): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0648Carbopol 934p<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_356\" aria-describedby=\"caption-attachment-356\" style=\"width: 581px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-356\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d17-300x225.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 (17): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0648Carbopol 934P \u0648HPMC K4M\" width=\"581\" height=\"436\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d17-300x225.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d17-768x576.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d17.jpg 1024w\" sizes=\"auto, (max-width: 581px) 100vw, 581px\" \/><figcaption id=\"caption-attachment-356\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 (17): \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0648Carbopol 934P \u0648HPMC K4M<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u062a\u0627\u0626\u062c \u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u062a\u062c\u0627\u0631\u064a\u0629 \u0641\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0639 \u0623\u0641\u0636\u0644 \u0635\u064a\u063a\u0629 \u062a\u062d\u0631\u0651\u0631 \u0645\u062f\u064a\u062f (<\/strong><strong>F11<\/strong><strong>):<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0638\u0647\u0631 \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u062a\u062d\u0631\u0651\u0631 \u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0627\u062f\u0651\u064e\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u062d\u0648\u0627\u0644\u064a (98.9%) \u062e\u0644\u0627\u0644 \u0627\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u060c \u0628\u064a\u0646\u0645\u0627 \u0644\u0645 \u064a\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a\u0629 F11 \u0633\u0648\u0649 (17.5)% \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u062f\u0629 \u0646\u0641\u0633\u0647\u0627.<\/span><\/p>\n<figure id=\"attachment_357\" aria-describedby=\"caption-attachment-357\" style=\"width: 576px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-357\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d18-300x217.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (18): \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0645\u0631\u062a\u0633\u0645 \u062a\u062d\u0631\u0631 \u0623\u0642\u0631\u0627\u0635 \u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0648\u0627\u0644\u0635\u064a\u063a\u0629 F11 \u062e\u0644\u0627\u0644 \u0627\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\" width=\"576\" height=\"417\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d18-300x217.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2023\/04\/\u0645\u062d18.png 510w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><figcaption id=\"caption-attachment-357\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 10pt;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u0627\u0644\u0634\u0643\u0644 (18): \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0645\u0631\u062a\u0633\u0645 \u062a\u062d\u0631\u0631 \u0623\u0642\u0631\u0627\u0635 \u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0648\u0627\u0644\u0635\u064a\u063a\u0629 F11 \u062e\u0644\u0627\u0644 \u0627\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0623\u0642\u0631\u0627\u0635 \u0630\u0627\u062a \u062e\u0648\u0627\u0635 \u0641\u064a\u0632\u064a\u0648\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u062c\u064a\u062f\u0629 \u0644\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644\u060c \u0648\u0625\u0646\u0651\u064e \u0632\u064a\u0627\u062f\u0629 \u0646\u0633\u0628 \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0635\u064a\u063a \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0625\u0628\u0637\u0627\u0621 \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0625\u0646\u064e \u0645\u0634\u0627\u0631\u0643\u0629 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 P934 \u0645\u0639 \u0628\u0644\u0645\u0631 HPMC K4M \u0623\u062f\u0651\u064e\u0649 \u0625\u0644\u0649 \u0636\u0628\u0637 \u0627\u0644\u062a\u062d\u0631\u0651\u0631\u060c \u0648\u062d\u0642\u0642\u062a \u0627\u0644\u0635\u064a\u063a\u0629 F11 \u0623\u0641\u0636\u0644 \u0633\u0644\u0648\u0643 \u062a\u062d\u0631\u0651\u0631 \u062e\u0644\u0627\u0644 12 \u0633\u0627\u0639\u0629\u060c \u0648\u0641\u0642 \u0645\u062a\u0637\u0644\u0628\u0627\u062a USP 38 \u2013 NF 33 \u0644\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0645\u062f\u064a\u062f\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0628\u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0648\u0632\u064a\u0627\u062f\u0629 \u0645\u0637\u0627\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0648\u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629. \u0623\u0639\u0637\u062a \u0623\u063a\u0644\u0628 \u0627\u0644\u0635\u064a\u063a \u062a\u062d\u0631\u0631\u0627\u064b \u0648\u0641\u0642 \u0646\u0645\u0637 Higuchi\u060c \u0628\u064a\u0646\u0645\u0627 \u0627\u0644\u0635\u064a\u063a\u0629 F11 \u062a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0646\u0645\u0637 \u062a\u062d\u0631\u0651\u0631 \u0645\u0646 \u0627\u0644\u0631\u062a\u0628\u0629 \u0635\u0641\u0631. \u0648\u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0648\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631 \u0628\u064a\u0646 \u0627\u0644\u0633\u064a\u0641\u0648\u0631\u0648\u0643\u0633\u064a\u0645 \u0623\u0643\u0633\u064a\u062a\u064a\u0644 \u0645\u0639 \u0627\u0644\u0643\u0627\u0631\u0628\u0648\u0628\u0648\u0644 934p\u060c \u0648\u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0645\u0639 \u0628\u0627\u0642\u064a \u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629. \u064a\u0648\u0635\u064a \u0627\u0644\u0628\u062d\u062b \u0628\u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0631\u0628\u0637 \u0628\u064a\u0646 \u0627\u0644\u0632\u062c\u0627\u062c \u0648\u0627\u0644\u0639\u0636\u0648\u064a\u0629 \u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u0627\u062d\u062a\u0628\u0627\u0633 \u0641\u064a \u0627\u0644\u0645\u0639\u062f\u0629 \u0648\u0627\u0644\u0637\u0641\u0648 \u0648\u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642 \u0627\u0644\u062d\u064a\u0648\u064a\u060c \u0648\u062a\u0642\u064a\u064a\u0645 \u0641\u0639\u0627\u0644\u064a\u062a\u0647\u0627.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u062a\u0628\u062f\u064a \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0645\u0633\u0627\u0648\u0626 \u0639\u062f\u064a\u062f\u0629\u060c \u0645\u0646 \u0628\u064a\u0646\u0647\u0627 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u062e\u0635\u0648\u0635\u0627\u064b \u0641\u064a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0630\u0627\u062a \u0646\u0635\u0641 \u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u062d\u064a\u0648\u064a&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=158\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":264,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-158","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-135","volume-9","year-10"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=158"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/158\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/264"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}