{"id":169,"date":"2022-04-01T16:37:57","date_gmt":"2022-04-01T16:37:57","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=169"},"modified":"2024-07-21T17:58:36","modified_gmt":"2024-07-21T17:58:36","slug":"%d8%af%d8%b1%d8%a7%d8%b3%d8%a9-%d8%a7%d8%b1%d8%aa%d8%a8%d8%a7%d8%b7-%d8%a8%d9%8a%d9%86-%d8%a7%d9%86%d8%ae%d9%81%d8%a7%d8%b6-%d8%a7%d9%84%d9%88%d8%b2%d9%86-%d9%88%d8%a7%d9%84%d8%ae%d8%b6%d8%a7%d8%a8","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=169","title":{"rendered":"\u062f\u0631\u0627\u0633\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648\u0627\u0644\u062e\u0636\u0627\u0628 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632\u064a \u0639\u0646\u062f \u0645\u0631\u0636\u0649 \u0645\u0639\u0627\u0644\u064e\u062c\u064a\u0646 \u0628\u0627\u0644\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0635\u064a\u0628 \u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0651\u0631\u064a \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062b\u0627\u0646\u064a Type 2 Diabetes Mellitus(T2DM) \u0623\u0643\u062b\u0631 \u0645\u0646 350 \u0645\u0644\u064a\u0648\u0646 \u0634\u062e\u0635 \u0639\u0627\u0644\u0645\u064a\u0627\u064b \u0643\u0645\u0627 \u064a\u0632\u062f\u0627\u062f \u0627\u0646\u062a\u0634\u0627\u0631\u0627\u064b, \u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u062a\u0648\u0641\u0651\u0631 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0627\u0644\u0632\u0645\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u062e\u0627\u0641\u0636\u0629 \u0644\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0625\u0644\u0627 \u0623\u0646\u0647\u0627 \u063a\u064a\u0631 \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0636\u0628\u0637 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645\u0648\u064a \u0644\u0645\u062f\u0651\u0629 \u0637\u0648\u064a\u0644\u0629 \u0636\u0628\u0637\u0627\u064b \u0643\u0627\u0641\u064a\u0627\u064b \u0639\u0646\u062f \u063a\u0627\u0644\u0628\u064a\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u062d\u062a\u0649 \u0648\u0625\u0646 \u0627\u0634\u062a\u0631\u0643\u062a \u0623\u0643\u062b\u0631 \u0645\u0646 \u0632\u0645\u0631\u0629 \u062f\u0648\u0627\u0626\u064a\u0629 \u0645\u0639\u0627\u064b<sup>1<\/sup>. \u0643\u0645\u0627 \u062a\u0631\u062a\u0628\u0637 \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062e\u0627\u0641\u0636\u0629 \u0644\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645\u0648\u064a \u0628\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0636\u0627\u0626\u0631\u0629 \u062a\u0646\u0639\u0643\u0633 \u0633\u0644\u0628\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0643\u0646\u0648\u0628\u0627\u062a \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645\u0648\u064a hypoglycemia \u0648\u0627\u0643\u062a\u0633\u0627\u0628 \u0627\u0644\u0648\u0632\u0646<sup>2<\/sup>. \u0627\u0644\u0623\u0645\u0631 \u0627\u0644\u0630\u064a \u064a\u0636\u0639\u0646\u0627 \u0641\u064a \u062d\u0627\u062c\u0629 \u0645\u0633\u062a\u0645\u0631\u0651\u0629 \u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0632\u0645\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0633\u0647\u0645 \u0641\u064a \u0636\u0628\u0637 \u0623\u0641\u0636\u0644 \u0644\u0647\u0630\u0627 \u0627\u0644\u062f\u0627\u0621 (T2DM). <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u064f\u0639\u062a\u0628\u0631 \u0645\u062b\u0628\u0651\u0637\u0627\u062a \u0627\u0644\u0646\u0627\u0642\u0644 \u0627\u0644\u0645\u0634\u0627\u0631\u0643 \u0635\u0648\u062f\u064a\u0648\u0645-\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u0646\u0645\u06372\u00a0 Sodium Glucose co-transporter Type 2 inhibitors (SGLT2is) \u0632\u0645\u0631\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0646\u0633\u0628\u064a\u0627\u064b \u062a\u062e\u0641\u0636 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645\u0648\u064a \u0628\u0622\u0644\u064a\u0629 \u0639\u0645\u0644 \u0645\u0633\u062a\u0642\u0644\u0629 \u0639\u0646 \u0627\u0644\u0627\u0646\u0633\u0648\u0644\u064a\u0646<sup>3,4<\/sup> \u062d\u064a\u062b \u062a\u0633\u062a\u0647\u062f\u0641 \u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0643\u0651\u0628\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a ( (SGLT2\u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0642\u0637\u0639\u0629 S1 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0623\u0646\u0627\u0628\u064a\u0628 \u0627\u0644\u0642\u0631\u064a\u0628\u0629 \u0641\u064a \u0627\u0644\u0643\u0644\u0649 \u0645\u062b\u0628\u0651\u0637\u0629\u064b \u0639\u0648\u062f\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0645\u0646 \u0627\u0644\u0643\u0644\u064a\u0629, \u0627\u0644\u0623\u0645\u0631 \u0627\u0644\u0630\u064a \u064a\u0633\u0628\u0628 \u0632\u064a\u0627\u062f\u0629 \u0625\u0637\u0631\u0627\u062d \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0641\u064a \u0627\u0644\u0628\u0648\u0644Urine Glucose Excretion (UGE) \u00a0<sup>5,6<\/sup> . \u0643\u0645\u0627 \u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0627\u0632\u062f\u064a\u0627\u062f \u0647\u0630\u0647 \u0627\u0644\u0643\u0645\u064a\u0651\u0629 \u0627\u0644\u0645\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0627\u0644\u0628\u0648\u0644 \u0645\u0639 \u0627\u0632\u062f\u064a\u0627\u062f \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<sup>7,8<\/sup>. \u00a0\u062a\u0645\u062a\u0644\u0643 \u0647\u0630\u0647 \u0627\u0644\u0632\u0645\u0631\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0645\u064a\u0632\u0629 \u0625\u0636\u0627\u0641\u064a\u0629 \u0639\u0646 \u0643\u0648\u0646\u0647\u0627 \u062a\u0636\u0628\u0637 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645\u0648\u064a \u0648\u0647\u064a \u0623\u0646\u0651\u0647\u0627 \u062a\u0646\u0642\u0635 \u0627\u0644\u0648\u0632\u0646 \u0628\u0633\u0628\u0628 \u062e\u0633\u0627\u0631\u0629 \u0627\u0644\u062d\u0631\u064a\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0632\u064a\u0627\u062f\u0629 \u0637\u0631\u062d \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0641\u064a \u0627\u0644\u0628\u0648\u0644 \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0625\u062f\u0631\u0627\u0631 \u0627\u0644\u062a\u0646\u0627\u0636\u062d\u064a<sup>5,6<\/sup>. \u0643\u0645\u0627 \u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0643\u0648\u0646 \u0646\u0642\u0635\u0627\u0646 \u0627\u0644\u0648\u0632\u0646 \u064a\u062d\u0635\u0644 \u0646\u062a\u064a\u062c\u0629 \u0644\u0646\u0642\u0635\u0627\u0646 \u0627\u0644\u0643\u062a\u0644\u0629 \u0627\u0644\u0634\u062d\u0645\u064a\u0629, \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0627\u0644\u062d\u0634\u0648\u064a\u0629 \u0648\u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u062a\u062d\u062a \u0627\u0644\u062c\u0644\u062f<sup>9<\/sup>. \u062d\u062f\u064a\u062b\u0627\u064b \u062f\u062e\u0644 \u0635\u0646\u0641\u0627\u0646 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0632\u0645\u0631\u0629 \u0627\u0644\u0635\u0646\u0627\u0639\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u0629 \u0648\u0647\u0645\u0627 \u0627\u064a\u0645\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646Empagliflozin \u00a0\u0628\u062c\u0631\u0639\u062a\u064a\u0647 10 \u064825 \u0645\u0644\u063a \u0648\u062f\u0627\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 Dapagliflozin \u0628\u062c\u0631\u0639\u062a\u064a\u0647 5 \u064810 \u0645\u0644\u063a. \u0648\u0646\u0638\u0631\u0627\u064b \u0644\u0643\u0644\u0651 \u0645\u0627 \u0648\u0631\u062f \u0630\u0643\u0631\u0647 \u0633\u0627\u0628\u0642\u0627\u064b \u0625\u0636\u0627\u0641\u0629\u064b \u0625\u0644\u0649 \u0627\u0646\u0639\u062f\u0627\u0645 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0648\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0641\u064a \u0633\u0648\u0631\u064a\u0627 \u062d\u0648\u0644 \u0647\u0630\u0647 \u0627\u0644\u0632\u0645\u0631\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0643\u0627\u0646 \u0645\u0646 \u0627\u0644\u0645\u0642\u062a\u0631\u062d \u0623\u0646 \u062a\u064f\u062f\u0631\u0633 \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646\u0627\u062a \u0627\u0644\u062e\u0627\u0641\u0636 \u0644\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0637\u0631\u0627\u0626\u0642 \u0648\u0623\u062f\u0648\u0627\u062a \u0627\u0644\u0628\u062d\u062b <\/strong><strong>Methods and Materials<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0628\u062d\u062b<\/strong><strong>Study population<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0631\u0636\u0649 \u0633\u0643\u0631\u064a\u064a\u0646 \u0645\u0646 \u0627\u0644\u0646\u0645\u06372 (T2DM) \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 18-75 \u0639\u0627\u0645\u0627\u064b \u0645\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u062e\u0636\u0627\u0628 \u063a\u0644\u0648\u0643\u0648\u0632\u064a HbA1C \u0623\u0643\u0628\u0631 \u0623\u0648 \u064a\u0633\u0627\u0648\u064a 7.5% \u0642\u0628\u0644 \u0627\u0644\u0628\u062f\u0621 \u0628\u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0643\u0645\u0627 \u0627\u0633\u062a\u064f\u0628\u0639\u062f \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0643\u0631\u064a \u0630\u0627\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0623\u062e\u0631\u0649 \u0623\u0648 \u0627\u0644\u0645\u0639\u0627\u0644\u064e\u062c\u064a\u0646 \u0628\u0627\u0644\u0627\u0646\u0633\u0648\u0644\u064a\u0646, \u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0648\u0627\u0644\u0645\u0631\u0636\u0639\u0627\u062a, \u0648\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0645\u0631\u0636\u0649 \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0643\u0644\u0648\u064a \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0645\u0639\u062f\u0644 \u0627\u0644\u0631\u0634\u062d \u0627\u0644\u0643\u0628\u064a\u0628\u064a <strong>eGFR<\/strong> \u0623\u0642\u0644 \u0645\u0646 45 \u0645\u0644. \u062f\u0642\u064a\u0642\u0629<sup>1-<\/sup>.1.73\u0645<sup>2-<\/sup>, \u0643\u0645\u0627 \u0627\u0633\u062a\u0628\u0639\u062f\u0646\u0627 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0633\u062a\u062e\u062f\u0645\u0648\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0646\u062d\u0651\u0641\u0629 \u0633\u0648\u0627\u0621 \u0646\u0628\u0627\u062a\u064a\u0629 \u0623\u0648 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0625\u0646\u062a\u0627\u0646\u0627\u062a \u0628\u0648\u0644\u064a\u0629 \u0639\u0646\u062f \u0627\u0644\u0628\u062f\u0621 \u0628\u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0648\u0628\u0639\u062f \u0639\u0631\u0636 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0646\u064a\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0642\u0628\u0644 \u0627\u0644\u0628\u062f\u0621 \u0628\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062d\u0635\u0644\u0646\u0627 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0627\u0646\u0636\u0645\u0651\u0648\u0627 \u0625\u0644\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong> <strong>Study Design<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u064f\u062c\u0631\u064a\u062a \u062f\u0631\u0627\u0633\u0629 \u062a\u0635\u0627\u0644\u0628\u064a\u0629 crossover, \u0645\u0639\u0634\u0651\u0627\u0629 randomized, \u062b\u0644\u0627\u062b\u064a\u0651\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 triple-blind, \u062b\u0646\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u0630\u0631\u0627\u0639, \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0645\u0631\u0643\u0632 mono-center \u00a0\u0644\u0645\u062f\u0629 24 \u0623\u0633\u0628\u0648\u0639\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u0631\u0627\u062c\u0639\u0648\u0627 \u0627\u0644\u0639\u064a\u0627\u062f\u0627\u062a \u0627\u0644\u063a\u062f\u064a\u0629 \u0644\u0644\u0639\u064a\u0627\u062f\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u0645\u062c\u0627\u0646\u064a\u0629 \u0641\u064a \u0639\u0631\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0629 \u0628\u064a\u0646 \u062a\u0634\u0631\u064a\u0646 \u0627\u0644\u0623\u0648\u0644 2019\u00a0 \u0648\u062a\u0634\u0631\u064a\u0646 \u0627\u0644\u0623\u0648\u0644 2020. \u062a\u0645\u0651 \u0633\u062d\u0628 \u0639\u064a\u0651\u0646\u0627\u062a\u00a0 \u062f\u0645\u0648\u064a\u0629 ( \u0628\u0639\u062f \u0635\u064a\u0627\u0645 8 \u0633\u0627\u0639\u0627\u062a). \u062a\u0645\u0651 \u0627\u0644\u062a\u0639\u0627\u0645\u0644 \u0645\u0639 \u0645\u0631\u0636\u0649 \u0633\u0643\u0631\u064a\u064a\u0646 (T2DM<strong>)<\/strong> \u063a\u064a\u0631 \u0645\u0636\u0628\u0648\u0637\u064a \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645\u0648\u064a((HbA1c&gt;7.5, \u0628\u062f\u0627\u064a\u0629 \u062e\u0636\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0644\u0641\u062a\u0631\u0629 <strong>washout period<\/strong> \u0644\u0625\u0632\u0627\u0644\u0629 \u0623\u064a \u0623\u062b\u0631 \u0644\u062e\u0627\u0641\u0636\u0627\u062a \u0627\u0644\u0633\u0643\u0651\u0631 \u0627\u0644\u0641\u0645\u0648\u064a\u0651\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645 \u0648\u0627\u0644\u062a\u064a \u0643\u0627\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0639\u0627\u0644\u064e\u062c\u064a\u0646 \u0628\u0647\u0627 \u0642\u0628\u0644 \u0627\u0644\u0628\u062f\u0621 \u0628\u0627\u0644\u062f\u0631\u0627\u0633\u0629 (\u0645\u062f\u0651\u0629 10 \u0623\u064a\u0627\u0645) \u0645\u0639 \u0648\u0636\u0639\u0647\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0641\u0642\u0637 \u0628\u062c\u0631\u0639\u0629 1000 \u0645\u0644\u063a \u0645\u0631\u062a\u064a\u0646 \u064a\u0648\u0645\u064a\u0627\u064b \u062b\u0645 \u0627\u0646\u0642\u0633\u0645 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0627\u064b \u0625\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646, \u0623\u064f\u062e\u0630\u062a \u0627\u0644\u0642\u064a\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u064a \u0627\u0644\u0644\u062d\u0638\u0629 \u0627\u0644\u0642\u0627\u0639\u062f\u064a\u0629 (\u0627\u0644\u0628\u062f\u0626\u064a\u0629) <strong>Baseline<\/strong>, \u0623\u064f\u0639\u0637\u064a\u00a0 \u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u00a0\u0627\u0644\u0623\u0648\u0644\u0649 \u00a0\u062f\u0648\u0627\u0621 \u0627\u064a\u0645\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 (\u0627\u064a\u0645\u0628\u0627) \u0627\u0644\u0645\u0631\u0645\u0648\u0632 \u0644\u0647 \u0628\u0627\u0644\u0631\u0645\u0632( (A\u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 ( \u062a\u0642\u062f\u0645\u0629 \u0634\u0631\u0643\u0629 \u0633\u064a\u062a\u064a \u0641\u0627\u0631\u0645\u0627 \u0644\u0644\u0635\u0646\u0627\u0639\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629, \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u06294277 , \u062a\u0627\u0631\u064a\u062e \u0625\u0646\u062a\u0627\u062c 2019 \u0645) \u062c\u0631\u0639\u0629 \u0648\u062d\u064a\u062f\u0629 \u064a\u0648\u0645\u064a\u0627\u064b 25 \u0645\u0644\u063a \u0628\u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0645\u0639 \u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0628\u062c\u0631\u0639\u0629 1000 \u0645\u0644\u063a \u0645\u0631\u062a\u064a\u0646 \u064a\u0648\u0645\u064a\u0627\u064b, \u0648\u0623\u064f\u0639\u0637\u064a \u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u062f\u0648\u0627\u0621 \u062f\u0627\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 (\u062f\u0627\u0628\u0627) \u0627\u0644\u0645\u0631\u0645\u0648\u0632 \u0644\u0647 \u0628\u0627\u0644\u0631\u0645\u0632( (B\u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 (\u062a\u0642\u062f\u0645\u0629 \u0634\u0631\u0643\u0629 \u0627\u0644\u0641\u0627\u0631\u0633 \u0644\u0644\u0635\u0646\u0627\u0639\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629, \u0631\u0642\u0645 \u0627\u0644\u0637\u0628\u062e\u0629 006, \u062a\u0627\u0631\u064a\u062e \u0625\u0646\u062a\u0627\u062c 2019 \u0645) \u062c\u0631\u0639\u0629 \u0648\u062d\u064a\u062f\u0629 10 \u0645\u0644\u063a \u0628\u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0645\u0639 \u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0628\u062c\u0631\u0639\u0629 1000 \u0645\u0644\u063a \u0645\u0631\u062a\u064a\u0646 \u064a\u0648\u0645\u064a\u0627\u064b \u0644\u0645\u062f\u0651\u0629 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631, \u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631 \u0623\u064f\u062e\u0630\u062a \u0627\u0644\u0642\u064a\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0645\u0651\u0631\u0629 \u0623\u062e\u0631\u0649(\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649) <strong>first period<\/strong> \u0648\u0645\u0646 \u062b\u0645\u0651 \u062e\u0636\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u0641\u062a\u0631\u0629 \u063a\u0633\u064a\u0644 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0645\u062f\u0651\u062a\u0647\u0627 \u00a07-10\u0623\u064a\u0627\u0645 \u0623\u064a \u062d\u0648\u0627\u0644\u064a \u0627\u0644\u0639\u0634\u0631\u0629 \u0623\u0639\u0645\u0627\u0631 \u0646\u0635\u0641\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062f\u0631\u0648\u0633 (\u0628\u0625\u064a\u0642\u0627\u0641 \u0627\u0644\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 \u0648\u0627\u0644\u0625\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0641\u0642\u0637)\u00a0 \u0648\u0645\u0646 \u062b\u0645\u0651 \u0628\u0627\u062f\u0644\u0646\u0627 \u0628\u064a\u0646 \u0627\u0644\u0630\u0631\u0627\u0639\u064a\u0646 \u0628\u0623\u0646 \u0623\u0639\u0637\u064a\u0646\u0627 \u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u0623\u0648\u0644\u0649 (\u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0645\u0639 \u0627\u0644\u062f\u0627\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646) \u0648\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (\u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0645\u0639 \u0627\u0644\u0627\u064a\u0645\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646)\u00a0 \u0628\u0630\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629\u00a0 \u0648\u0627\u0633\u062a\u0645\u0631\u064a\u0646\u0627 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631 \u0623\u062e\u0631\u0649 \u0641\u064a \u0646\u0647\u0627\u064a\u062a\u0647\u0627 \u0623\u0639\u062f\u0646\u0627 \u0623\u062e\u0630 \u0627\u0644\u0642\u064a\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0644\u0644\u0645\u0631\u0629 \u0627\u0644\u0623\u062e\u064a\u0631\u0629 ( \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629) second period. \u062a\u0645\u0651 \u0642\u064a\u0627\u0633 HbA1c \u0648\u0641\u0642 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062a\u0623\u0644\u0651\u0642 \u0627\u0644\u0645\u0646\u0627\u0639\u064a Immunofluorescence Assay \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 I-chroma HbA1c analyzer (Boditech MED., INC.,\u00a0 Korea<strong>)<\/strong>. \u0648\u0627\u0644\u062a\u0623\u0643\u0651\u062f \u0645\u0646 \u0645\u0637\u0627\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u062a\u0632\u0627\u0645\u0647\u0645 \u0628\u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0628\u0631 \u0627\u062a\u0635\u0627\u0644\u0627\u062a \u0647\u0627\u062a\u0641\u064a\u0629 \u062f\u0648\u0631\u064a\u0629 \u0645\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0639\u062f\u0651 \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629 \u0641\u064a \u0627\u0644\u0639\u0628\u0648\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629. \u0648\u0645\u0646 \u0627\u0644\u062c\u062f\u064a\u0631 \u0628\u0627\u0644\u0630\u0643\u0631 \u0623\u0646\u0651 \u0627\u0644\u0639\u0628\u0648\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0643\u0627\u0646\u062a \u0645\u062a\u0645\u0627\u062b\u0644\u0629 \u062c\u0645\u064a\u0639\u0627\u064b \u0628\u0627\u0644\u0634\u0643\u0644 \u0648\u0639\u062f\u062f \u0627\u0644\u0645\u0636\u063a\u0648\u0637\u0627\u062a \u0645\u0645\u0627 \u064a\u0636\u0645\u0646 \u062a\u0639\u0645\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0639\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 \u0648\u0627\u0644\u0637\u0628\u064a\u0628 \u0648\u0627\u0644\u0645\u062d\u0644\u0651\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a\u0629 \u0648\u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0644\u0644\u0628\u064a\u0627\u0646\u0627\u062a <\/strong><strong>Statistical Analyses<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u062d\u0632\u0645\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0627\u062c\u062a\u0645\u0627\u0639\u064a\u0629 (SPSS) \u0627\u0644\u0646\u0633\u062e\u0629 25 \u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a SPSS version 25.0 (IBM Corp., Armonk, NY, USA) \u062c\u0631\u0649 \u062a\u0648\u0635\u064a\u0641 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0629 \u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0643\u0640 \u0645\u062a\u0648\u0633\u0637 \u062d\u0633\u0627\u0628\u064a \u00b1 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0623\u0645\u0627 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0641\u0626\u0648\u064a\u0629 \u0641\u0642\u062f \u062c\u0631\u0649 \u062a\u0648\u0635\u064a\u0641\u0647\u0627 \u0643\u0646\u0633\u0628\u0629 \u0645\u0626\u0648\u064a\u0629. \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 paired T-test \u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0641\u0631\u0642 \u0641\u064a \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0646\u062f \u0644\u062d\u0638\u0629 \u0627\u0644\u0628\u062f\u0621 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0643\u0645\u0627 \u062f\u064f\u0631\u0633\u062a \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648HBA1C \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0631\u0633\u0648\u0646 \u00a0Pearson correlation coefficient \u0644\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u062a\u0628\u0639 \u0627\u0644\u062a\u0648\u0632\u0639 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u060c \u0648\u0627\u0631\u062a\u0628\u0627\u0637 \u0633\u0628\u064a\u0631\u0645\u0627\u0646 Spearman correlation coefficient \u0639\u0646\u062f \u0631\u0641\u0636 \u0641\u0631\u0636\u064a\u0629 \u0627\u0644\u062a\u0648\u0632\u0639 \u0627\u0644\u0637\u0628\u064a\u0639\u064a (\u0648\u0630\u0644\u0643 \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0627\u062e\u062a\u0628\u0627\u0631 Shapiro-Wilk \u0627\u0644\u0645\u0637\u0628\u0651\u0642 \u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u0631\u0636\u064a\u0629 \u0627\u0644\u062a\u0648\u0632\u0639 \u0627\u0644\u0637\u0628\u064a\u0639\u064a) \u00a0\u0648\u0630\u0644\u0643 \u0644\u062f\u0631\u0627\u0633\u0629 \u0642\u0648\u0629 \u0648\u062c\u0647\u0629 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0645\u062a\u063a\u064a\u0631\u064a\u0646 \u0639\u0646\u062f \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u0627\u064a\u0645\u0628\u0627 ((A (n=37, \u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0639\u062f \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u064a \u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u0623\u0648\u0644\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 first period \u0648\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 ( second period \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u062f\u0627\u0628\u0627 ((B (n=37, \u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u0623\u0648\u0644\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 second period \u0648\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649first period \u00a0(. \u0623\u064f\u062c\u0631\u064a\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0623\u0643\u0645\u0644\u0648\u0627 \u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062d\u062a\u0649 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0641\u0642\u0637 \u0648\u0641\u0642 \u0645\u0628\u062f\u0623 per-protocol principle \u0627\u0639\u062a\u064f\u0645\u062f\u062a \u0642\u064a\u0645\u0629 p-value=0.05 \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0641\u0631\u0648\u0642 \u0627\u0644\u062c\u0648\u0647\u0631\u064a\u0629 \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062b\u0642\u0629 \u0642\u062f\u0631\u0647 95%.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong><strong>Results<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0639\u064a\u0651\u0646\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 <\/strong><strong>\u00a0<\/strong><strong>\u00a0<\/strong><strong>Patients characteristics<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u064a\u0646 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0629 \u0628\u064a\u0646 \u062a\u0634\u0631\u064a\u0646 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2019\u0645 \u0648\u062a\u0634\u0631\u064a\u0646 \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0639\u0627\u0645 2020\u0645 \u062f\u064f\u0631\u0633\u062a \u0628\u064a\u0627\u0646\u0627\u062a 85 \u0645\u0631\u064a\u0636\u0627\u064b, 47 \u0645\u0646\u0647\u0645 \u062d\u0642\u0651\u0642\u0648\u0627 \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0634\u062a\u0645\u0627\u0644 \u0648\u0642\u0628\u0644\u0648\u0627 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629, 37 \u0645\u0631\u064a\u0636\u0627\u064b \u0641\u0642\u0637 \u0645\u064e\u0646 \u0623\u0643\u0645\u0644\u0648\u0627 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0647\u0645 \u0627\u0644\u0630\u064a\u0646 \u062e\u0636\u0639\u0648\u0627 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u00a0(\u0645\u062e\u0637\u0637 1). \u062a\u0636\u0645\u0651\u0646\u062a \u0639\u064a\u0651\u0646\u0629 \u0628\u062d\u062b\u0646\u0627 24.3% \u0645\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u064875.7% \u0645\u0646 \u0627\u0644\u0625\u0646\u0627\u062b \u0648\u0642\u062f \u0643\u0627\u0646 \u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u0648\u0633\u0637\u064a\u00b1 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a 55\u00b18 \u0633\u0646\u0629, \u0648\u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0648\u0633\u0637\u064a\u00b1 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a 72.81\u00b110.84 \u0643\u063a, \u0643\u0645\u0627 \u0644\u0645 \u062a\u0648\u062c\u062f \u0623\u064a \u0641\u0631\u0648\u0642 \u062c\u0648\u0647\u0631\u064a\u0651\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0641\u064a \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0646\u062f \u0644\u062d\u0638\u0629 \u0627\u0644\u0628\u062f\u0621 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u064a\u0645\u0628\u0627 \u00a0\u00a0A\u0648\u062f\u0627\u0628\u0627 B (\u062c\u062f\u0648\u0644 1). \u0643\u0645\u0627 \u0648\u0631\u062f\u062a \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0630\u0631\u0627\u0639\u064a\u0646 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0639\u0646\u062f \u0644\u062d\u0638\u0629 \u0627\u0644\u0628\u062f\u0621 baseline \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (2).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-547\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-43-280x300.png\" alt=\"\" width=\"440\" height=\"471\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-43-280x300.png 280w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-43-957x1024.png 957w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-43-768x821.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-43-1436x1536.png 1436w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-43-1915x2048.png 1915w\" sizes=\"auto, (max-width: 440px) 100vw, 440px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-548\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-44-300x174.png\" alt=\"\" width=\"740\" height=\"429\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-44-300x174.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-44-1024x593.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-44-768x445.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-44-1536x890.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-44-2048x1187.png 2048w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-549 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-45-e1699091428592-300x257.png\" alt=\"\" width=\"696\" height=\"596\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-45-e1699091428592-300x257.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-45-e1699091428592-1024x877.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-45-e1699091428592-768x658.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-45-e1699091428592-1536x1315.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-45-e1699091428592-2048x1753.png 2048w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u00a03-2 \u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u064a\u0651\u0629 <\/strong><strong>Primary endpoint<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633\u062a \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648HBA1C\u00a0 \u0641\u064a \u0643\u0644 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u0627\u064a\u0645\u0628\u0627 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u062f\u0627\u0628\u0627 \u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0627\u0633\u062a\u062e\u062f\u0645\u0648\u0627 \u0643\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621\u064a\u0646 \u0623\u064a 37 \u0645\u0631\u064a\u0636\u0627\u064b \u0641\u064a \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0631\u062a\u0628\u0627\u0637 \u0633\u0628\u064a\u0631\u0645\u0627\u0646 \u0627\u0644\u0628\u062f\u064a\u0644 \u0627\u0644\u0644\u0627 \u0645\u0639\u0644\u0645\u064a \u0646\u062a\u064a\u062c\u0629 \u0644\u0639\u062f\u0645 \u062a\u062d\u0642\u0642 \u0641\u0631\u0636\u064a\u0629 \u0627\u0644\u062a\u0648\u0632\u0639 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u062c\u0648\u0647\u0631\u064a\u0629 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648HBA1C \u0639\u0646\u062f \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u0627\u064a\u0645\u0628\u0627 \u062d\u064a\u062b \u0643\u0627\u0646\u062a (r=-0.208; p-value=0.216) \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062b\u0642\u0629 .95% \u0643\u0645\u0627 \u062a\u0628\u064a\u0646 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u062c\u0648\u0647\u0631\u064a\u0629 \u0637\u0631\u062f\u064a\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648HBA1C \u00a0\u0639\u0646\u062f \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u062f\u0627\u0628\u0627 \u062d\u064a\u062b \u0643\u0627\u0646\u062a (r=0.575; p-value=0.000) \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062b\u0642\u0629 \u00a095% \u062c\u062f\u0648\u0644 (3), \u0645\u062e\u0637\u0637 (2).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-550\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-46-300x132.png\" alt=\"\" width=\"516\" height=\"227\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-46-300x132.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-46-1024x449.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-46-768x337.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-46-1536x673.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-46-2048x898.png 2048w\" sizes=\"auto, (max-width: 516px) 100vw, 516px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-551\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-47-290x300.png\" alt=\"\" width=\"535\" height=\"553\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-47-290x300.png 290w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-47-990x1024.png 990w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-47-768x794.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-47-1485x1536.png 1485w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-47.png 1863w\" sizes=\"auto, (max-width: 535px) 100vw, 535px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-552\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-48-300x269.png\" alt=\"\" width=\"541\" height=\"485\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-48-300x269.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-48-1024x917.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-48-768x688.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-48-1536x1375.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/04\/1-48.png 1872w\" sizes=\"auto, (max-width: 541px) 100vw, 541px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Discussion<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0647\u062f\u0641 \u0645\u0639\u0627\u0644\u062c\u0629 \u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0631\u064aT2DM)) \u0625\u0644\u0649 \u062a\u0623\u062e\u064a\u0631 \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u0645\u0631\u0636 \u0648\u062a\u062d\u0642\u064a\u0642 \u062c\u0648\u062f\u0629 \u062d\u064a\u0627\u0629 \u0623\u0645\u062b\u0644 \u0644\u0644\u0645\u0631\u064a\u0636<sup>10<\/sup>, \u0648\u062a\u0642\u062a\u0631\u062d \u0627\u0644\u062f\u0644\u0627\u0626\u0644 \u0627\u0644\u0625\u0631\u0634\u0627\u062f\u064a\u0629 \u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0631\u064aT2DM) ) \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0639\u0644\u0649 \u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0645\u0631\u064a\u0636 \u0630\u0627\u062a\u0647 \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636 patient-centered strategy <sup>10<\/sup> \u0648\u0630\u0644\u0643 \u0628\u0627\u0644\u0623\u062e\u0630 \u0628\u0639\u064a\u0646 \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0627\u0644\u0648\u0627\u0631\u062f \u062d\u062f\u0648\u062b\u0647\u0627 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0643\u0627\u0646\u062e\u0641\u0627\u0636 \u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u062f\u0645 \u0648\u0627\u0643\u062a\u0633\u0627\u0628 \u0627\u0644\u0648\u0632\u0646 \u0648\u0627\u062d\u062a\u0628\u0627\u0633 \u0627\u0644\u0633\u0648\u0627\u0626\u0644. \u0648\u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0633\u0643\u0631\u064a \u0639\u0627\u0644\u0645\u064a\u0627\u064b \u0646\u0638\u0631\u0627\u064b \u0644\u0627\u0632\u062f\u064a\u0627\u062f \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0628\u062f\u0627\u0646\u0629<sup>11<\/sup> \u0643\u0627\u0646 \u0644\u062a\u0623\u062b\u064a\u0631 SGLT2is \u0627\u0644\u062e\u0627\u0641\u0636 \u0644\u0644\u0648\u0632\u0646 \u0623\u0647\u0645\u064a\u0629 \u0648\u0627\u0636\u062d\u0629 \u0641\u064a \u0645\u0639\u0627\u0644\u062c\u0629T2DM \u00a0<sup>9,12\u201315<\/sup>. \u0648\u0645\u0646 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0623\u0646 SGLT2is \u062a\u0646\u0642\u0635 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u0628\u0644\u0627\u0633\u0645\u064a\u0629 \u0639\u0628\u0631 \u0632\u064a\u0627\u062f\u0629 \u0637\u0631\u062d \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0641\u064a \u0627\u0644\u0628\u0648\u0644 (\u062a\u0632\u062f\u0627\u062f \u0647\u0630\u0647 \u0627\u0644\u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0637\u0631\u0648\u062d\u0629 \u0628\u0627\u0632\u062f\u064a\u0627\u062f \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u0628\u0644\u0627\u0633\u0645\u064a\u0629) \u0643\u0645\u0627 \u062a\u0646\u0642\u0635 \u0627\u0644\u0648\u0632\u0646 \u0628\u0634\u0643\u0644 \u062c\u0648\u0647\u0631\u064a \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649<sup>16\u201318<\/sup>. \u0648\u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0643\u0648\u0646 \u0627\u0644\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646\u0627\u062a \u062a\u0646\u0642\u0635 \u0627\u0644\u0648\u0632\u0646 \u0628\u0625\u0646\u0642\u0627\u0635 \u0627\u0644\u0643\u062a\u0644\u0629 \u0627\u0644\u0634\u062d\u0645\u064a\u0629, \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0627\u0644\u062d\u0634\u0648\u064a\u0629 \u0648\u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u062a\u062d\u062a \u0627\u0644\u062c\u0644\u062f<sup>9<\/sup>. \u0648\u0645\u0646 \u0647\u0646\u0627 \u0643\u0627\u0646 \u0645\u0646 \u0627\u0644\u0645\u0642\u062a\u0631\u062d \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 \u0627\u0644\u062e\u0627\u0641\u0636 \u0644\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0645\u0639 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0648\u0636\u062d\u062a \u062f\u0631\u0627\u0633\u062a\u0627\u0646 \u0631\u0635\u062f\u064a\u062a\u0627\u0646 \u0643\u0648\u0631\u064a\u062a\u0627\u0646 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u062e\u0636\u0627\u0628 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632\u064a \u0639\u0646\u062f \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u0627\u064a\u0645\u0628\u0627<sup>19<\/sup> \u0648\u0645\u0633\u062a\u062e\u062f\u0645\u064a \u062f\u0627\u0628\u0627<sup>20<\/sup> \u0648\u0627\u0642\u062a\u0631\u062d\u0648\u0627 \u062a\u0641\u0633\u064a\u0631\u0627\u064b \u0644\u0646\u062a\u0627\u0626\u062c \u0639\u062f\u0645 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648HBA1C \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0632\u064a\u0627\u062f\u0629 \u0641\u0631\u0637 \u0627\u0644\u0637\u0639\u0627\u0645 \u0643\u0622\u0644\u064a\u0629 \u062a\u0639\u0648\u064a\u0636\u064a\u0629 compensatory hyperphagia \u00a0\u0627\u0644\u062a\u064a \u0642\u062f \u062a\u064f\u0634\u0627\u0647\u062f \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u062f\u064a\u0646\u064a\u0646<sup>21<\/sup> \u0648\u0645\u0627 \u064a\u062f\u0639\u0645 \u0647\u0630\u0627 \u0627\u0644\u0627\u0642\u062a\u0631\u0627\u062d \u0643\u0648\u0646 \u062e\u0633\u0627\u0631\u0629 \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0645\u0633\u0628\u0651\u0628\u0629 \u0628\u0627\u0644\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 \u0623\u0642\u0644 \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u0645\u062d\u0633\u0648\u0628\u0629 \u0645\u0646 \u0643\u0645\u064a\u0629 \u0627\u0644\u062d\u0631\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0641\u0642\u0648\u062f\u0629 \u062c\u0631\u0627\u0621 \u0637\u0631\u062d \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0641\u064a \u0627\u0644\u0628\u0648\u0644<sup>22<\/sup> \u0643\u0645\u0627 \u062a\u0634\u064a\u0631 \u0628\u0639\u0636 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0643\u0648\u0646 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0628\u062f\u064a\u0646\u064a\u0646 \u064a\u0645\u062a\u0635\u0648\u0646 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0645\u0646 \u0627\u0644\u0639\u0641\u062c \u0628\u0635\u0648\u0631\u0629 \u0623\u0643\u0628\u0631 \u0639\u0628\u0631 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a SGLT1 \u0627\u0644\u062a\u064a \u064a\u0632\u062f\u0627\u062f \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646\u0647\u0627 \u0639\u0646\u062f \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649<sup>23<\/sup> \u0625\u0644\u0627 \u0623\u0646\u0651 \u0630\u0644\u0643 \u0642\u062f \u064a\u062e\u062a\u0644\u0641 \u062d\u0633\u0628 \u0627\u0644\u0639\u0650\u0631\u0642 \u0648\u0647\u0648 \u0645\u0627\u0644\u0645 \u064a\u064f\u062f\u0631\u0633 \u0641\u064a \u0627\u0644\u0623\u062f\u0628 \u0627\u0644\u0637\u0628\u064a \u062d\u062a\u0649 \u0627\u0644\u0622\u0646. \u0648\u0623\u0648\u0635\u062a\u0627 \u0628\u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0627\u0633\u062a\u0628\u0627\u0642\u064a\u0629 prospective \u062a\u0633\u062a\u0642\u0635\u064a \u0628\u0648\u0636\u0648\u062d \u0623\u0643\u0628\u0631 \u0647\u0630\u0647 \u0627\u0644\u0639\u0644\u0627\u0642\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0637\u0631\u062f\u064a\u0629 \u062c\u0648\u0647\u0631\u064a\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648HBA1C \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0627\u0633\u062a\u062e\u062f\u0645\u0648\u0627 \u062f\u0648\u0627\u0621 \u062f\u0627\u0628\u0627, \u0645\u0639 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u062c\u0648\u0647\u0631\u064a\u0629 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648HBA1C \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0627\u0633\u062a\u062e\u062f\u0645\u0648\u0627 \u062f\u0648\u0627\u0621 \u0627\u064a\u0645\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 \u0623\u064a \u0627\u062a\u0641\u0642\u062a \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629Cho 2019 \u00a0\u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0639\u0644\u0649 \u0627\u0644\u0627\u064a\u0645\u0628\u0627 <sup>19<\/sup> \u0625\u0644\u0627 \u0623\u0646\u0647\u0627 \u062a\u0639\u0627\u0631\u0636\u062a \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 Lee 2016 \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0639\u0644\u0649 \u0627\u0644\u062f\u0627\u0628\u0627 <sup>20<\/sup>. \u0623\u0634\u0627\u0631 kosugi 2019 \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u062f\u0627\u0628\u0627 \u0644\u0627 \u064a\u062d\u0631\u0651\u0636compensatory hyperphagia <sup>24<\/sup> \u0643\u0645\u0627 \u0623\u0634\u0627\u0631\u062a \u062f\u0631\u0627\u0633\u0629 SEASAW 2020 \u0625\u0644\u0649 \u0623\u0646\u0651 \u0627\u0644\u0627\u064a\u0645\u0628\u0627 \u0644\u0627\u064a\u063a\u064a\u0651\u0631 \u0645\u0646 \u0634\u0647\u064a\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0644\u0644\u0637\u0639\u0627\u0645 \u00a0\u0625\u0644\u0627 \u0623\u0646\u0647 \u064a\u0633\u0628\u0651\u0628 \u0627\u0646\u062e\u0641\u0627\u0636\u0627\u064b \u0641\u064a \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0639\u0627\u0644\u064e\u062c\u064a\u0646 \u0628\u0647<sup>25<\/sup>. \u0627\u0644\u0623\u0645\u0631 \u0627\u0644\u0630\u064a \u064a\u0648\u0635\u064a \u0628\u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u062a\u062f\u0631\u0633 \u0647\u0630\u0627 \u0627\u0644\u0623\u062b\u0631 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0639\u0627\u0644\u064e\u062c\u064a\u0646 \u0628\u0627\u0644\u062f\u0627\u0628\u0627. \u0648\u0645\u0646 \u0627\u0644\u062c\u062f\u064a\u0631 \u0628\u0627\u0644\u0630\u0643\u0631 \u0623\u0646\u0651 \u062f\u0631\u0627\u0633\u0629 lee \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0642\u062f \u062f\u0631\u0633\u062a \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u064a\u0646 \u0641\u064a \u0641\u062a\u0631\u0629 \u0643\u0627\u0646\u062a \u0648\u0633\u0637\u064a\u0627\u064b 203 \u064a\u0648\u0645\u0627\u064b \u0648\u0645\u0645\u0627 \u0642\u062f \u064a\u0641\u0633\u0651\u0631 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0623\u062b\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0644\u0644\u062f\u0627\u0628\u0627 \u0628\u064a\u0646 \u0627\u0644\u0623\u0645\u062f \u0627\u0644\u0642\u0635\u064a\u0631 short-term \u0648\u0627\u0644\u0623\u0645\u062f \u0627\u0644\u0637\u0648\u064a\u0644 long-term\u00a0 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629<sup>26<\/sup>. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0645\u062a\u0627\u0632 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0628\u0643\u0648\u0646\u0647 \u0627\u0644\u0623\u0648\u0644 \u0627\u0644\u0630\u064a \u062f\u0631\u0633 \u0647\u0630\u0647 \u0627\u0644\u0632\u0645\u0631\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0639\u0644\u0649 \u0645\u0631\u0636\u0649 \u0633\u0648\u0631\u064a\u064a\u0646 \u0643\u0645\u0627 \u064a\u0645\u062a\u0627\u0632 \u0628\u062a\u0635\u0645\u064a\u0645\u0647 \u0627\u0644\u0630\u064a \u0644\u063a\u0649 \u0623\u064a \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0628\u062d\u062b \u0639\u0644\u0649 \u0627\u0639\u062a\u0628\u0627\u0631 \u0623\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0647\u0645 \u0630\u0627\u062a\u0647\u0645 \u0641\u064a \u0643\u0644\u062a\u0627 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u00a0A\u0648B \u0645\u0645\u0627 \u064a\u062c\u0639\u0644 \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u0648\u0627\u0621\u064a\u0646 \u062a\u0638\u0647\u0631 \u0628\u0635\u0648\u0631\u0629 \u0623\u062f\u0642 \u0648\u0623\u0648\u0636\u062d. \u0625\u0644\u0627 \u0623\u0646\u0647 \u064a\u0645\u062a\u0644\u0643 \u0628\u0639\u0636 \u0627\u0644\u0645\u062d\u062f\u0648\u062f\u064a\u0627\u062a \u0643\u0639\u062f\u0645 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0641\u064a \u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0636\u0649 (\u0631\u064a\u0627\u0636\u0629 \u0623\u0648 \u0646\u0638\u0627\u0645 \u063a\u0630\u0627\u0626\u064a) \u0643\u0645\u0627 \u0644\u0645 \u064a\u062a\u0645 \u0642\u064a\u0627\u0633 \u0643\u0645\u064a\u0629 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u0645\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0627\u0644\u0628\u0648\u0644 \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0643\u0645\u064a\u0629 \u0642\u062f \u062a\u062e\u062a\u0644\u0641 \u0628\u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u064a\u0636, \u0645\u0645\u0627 \u064a\u0648\u0635\u064a \u0628\u0625\u062c\u0631\u0627\u0621 \u0623\u0628\u062d\u0627\u062b \u0623\u062e\u0631\u0649 \u062a\u062f\u0631\u0633 \u062a\u0623\u062b\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0639\u0648\u0627\u0645\u0644\u00a0\u00a0 ( \u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629, \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0648\u0643\u0645\u064a\u0629 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u0645\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0627\u0644\u0628\u0648\u0644) \u0639\u0644\u0649 \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0639\u0646\u062f \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u0627\u064a\u0645\u0628\u0627 \u0648\u0645\u0633\u062a\u062e\u062f\u0645\u064a \u062f\u0627\u0628\u0627 \u0648\u0627\u0633\u062a\u0642\u0635\u0627\u0621 \u0623\u064a \u0641\u0631\u0648\u0642 \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621\u064a\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c <\/strong><strong>Conclusion<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0634\u0627\u0631\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0628\u064a\u0646 \u062f\u0648\u0627\u0621\u064a \u062f\u0627\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 \u0648\u0627\u064a\u0645\u0628\u0627\u063a\u0644\u064a\u0641\u0644\u0648\u0632\u064a\u0646 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u064e\u0645\u064a\u0646 \u0639\u0646\u062f \u0630\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u0649 \u064a\u064f\u0639\u062a\u0642\u062f \u0623\u0646 \u064a\u0639\u0648\u062f \u0630\u0644\u0643 \u0625\u0644\u0649 \u0627\u062e\u062a\u0644\u0627\u0641 \u0623\u062b\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0639\u0644\u0649 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u00a0 \u0645\u0645\u0627 \u064a\u0648\u0635\u064a \u0628\u0625\u062c\u0631\u0627\u0621 \u0623\u0628\u062d\u0627\u062b \u0623\u062e\u0631\u0649 \u0630\u0627\u062a \u0639\u062f\u062f \u0645\u0631\u0636\u0649 \u0623\u0643\u0628\u0631 \u0648\u0645\u062f\u0629 \u062f\u0631\u0627\u0633\u0629 \u0623\u0637\u0648\u0644 \u062a\u062f\u0631\u0633 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 (\u0627\u0644\u0648\u0627\u0631\u062f \u0627\u0644\u063a\u0630\u0627\u0626\u064a, \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0648\u0643\u0645\u064a\u0629 \u0627\u0644\u063a\u0644\u0648\u0643\u0648\u0632 \u0627\u0644\u0645\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0627\u0644\u0628\u0648\u0644) \u0639\u0644\u0649 \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0639\u0646\u062f \u0645\u0633\u062a\u062e\u062f\u0645\u064a \u0627\u064a\u0645\u0628\u0627 \u0648\u0645\u0633\u062a\u062e\u062f\u0645\u064a \u062f\u0627\u0628\u0627 \u0648\u0627\u0633\u062a\u0642\u0635\u0627\u0621 \u0623\u064a \u0641\u0631\u0648\u0642 \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621\u064a\u0646.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u064a\u0635\u064a\u0628 \u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0651\u0631\u064a \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062b\u0627\u0646\u064a Type 2 Diabetes Mellitus(T2DM) \u0623\u0643\u062b\u0631 \u0645\u0646 350 \u0645\u0644\u064a\u0648\u0646 \u0634\u062e\u0635 \u0639\u0627\u0644\u0645\u064a\u0627\u064b \u0643\u0645\u0627 \u064a\u0632\u062f\u0627\u062f \u0627\u0646\u062a\u0634\u0627\u0631\u0627\u064b, \u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=169\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":551,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-133","volume-8"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=169"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/169\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/551"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}