{"id":1797,"date":"2024-09-01T13:41:13","date_gmt":"2024-09-01T13:41:13","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=1797"},"modified":"2025-01-06T09:36:51","modified_gmt":"2025-01-06T09:36:51","slug":"%d8%aa%d8%a3%d8%ab%d9%8a%d8%b1-%d8%a7%d9%84%d8%aa%d8%b9%d8%af%d9%91%d8%af-%d8%a7%d9%84%d8%b4%d9%83%d9%84%d9%8a-%d9%85%d9%81%d8%b1%d8%af-%d8%a7%d9%84%d9%86%d9%8a%d9%83%d9%84%d9%8a%d9%88%d8%aa%d9%8a","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=1797","title":{"rendered":"\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0644\u062c\u064a\u0646SLCO1B1 \u0641\u064a \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0627\u0644\u0633\u0648\u0631\u064a\u064a\u0640\u0640\u0646"},"content":{"rendered":"

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\u0627\u0644\u0645\u0648\u0642\u0639 521 \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u0633\u0627\u062f\u0633\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0633\u062a\u0628\u062f\u0627\u0644 \u0627\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u064a \u0627\u0644\u0633\u064a\u062a\u0648\u0632\u064a\u0646 \u0628\u0627\u0644\u062a\u0627\u064a\u0645\u064a\u0646 \u0627\u0633\u062a\u0628\u062f\u0627\u0644\u0627\u064b \u063a\u064a\u0631 \u0645\u0631\u0627\u062f\u0641nonsynonymous \u00a0\u064a\u0646\u062c\u0645 \u0639\u0646\u0647 \u062a\u0648\u0636\u0651\u0639 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a \u0627\u0644\u0623\u0644\u0627\u0646\u064a\u0646 \u0628\u062f\u0644\u0627\u064b \u0639\u0646 \u0627\u0644\u0641\u0627\u0644\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 174 \u0645\u0646 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\u062a\u0636\u062e\u064a\u0645\u0647\u0627 \u0644\u0644\u062a\u0633\u0644\u0633\u0644\u0627\u062a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0641\u064a \u062c\u064a\u0646 SLCO1B1<\/em> \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u062f\u0627\u0629 Primer BLAST (Basic Local Alignment Search Tool)\u060c \u062b\u0645 \u0627\u0644\u062a\u062d\u0642\u0651\u0642 \u0645\u0646 \u0646\u0648\u0639\u064a\u0651\u062a\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0648\u0642\u0639 MFEprimer. \u0623\u064f\u062c\u0631\u064a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u062a\u0633\u0644\u0633\u0644\u064a PCR \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u062f\u0648\u0651\u0631 \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0645\u0646 \u0634\u0631\u0643\u0629 SENSEQUEST\u00ae \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064a\u0651\u0629. \u0627\u0639\u062a\u064f\u0645\u0650\u062f\u064e\u062a \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u0648\u0627\u0631\u062f\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (1) \u0641\u064a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0640 PCR \u0628\u0639\u062f \u0623\u0646 \u062e\u0636\u0639\u062a \u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0623\u0645\u0652\u062b\u064e\u0644\u064e\u0629\u060c \u062d\u064a\u062b \u062a\u0637\u0644\u0651\u0628 \u0627\u0644\u062a\u0641\u0627\u0639\u0644: 50 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645 \u0645\u0646 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a\u060c 5 \u0628\u064a\u0643\u0648\u0645\u0648\u0644 \u0645\u0646 \u0643\u0644\u0651\u064d \u0645\u0646 \u0627\u0644\u0645\u064f\u0631\u064e\u0626\u0650\u0633\u064a\u0646 \u0627\u0644\u062a\u0642\u062f\u0651\u0645\u064a \u0648\u0627\u0644\u0639\u0643\u0633\u064a\u060c \u064810 \u0645\u064a\u0643\u0631\u0648\u0644\u062a\u0631 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0631\u0626\u064a\u0633\u064a Master Mix 2X\u060c \u0648\u062a\u0645 \u0625\u062a\u0645\u0627\u0645 \u0627\u0644\u062d\u062c\u0645 \u062d\u062a\u0649 20 \u0645\u064a\u0643\u0631\u0648\u0644\u062a\u0631 \u0628\u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0651\u0631. \u0631\u064f\u062d\u0651\u0650\u0644\u064e\u062a \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0636\u062e\u064a\u0645 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0640 PCR \u0639\u0644\u0649 \u0647\u064f\u0644\u0627\u0645\u0629 \u0623\u063a\u0627\u0631\u0648\u0632 (GeneDireX\u060c \u062a\u0627\u064a\u0648\u0627\u0646) \u0628\u062a\u0631\u0643\u064a\u0632 1.5% \u0644\u0645\u062f\u0629 25 \u062f\u0642\u064a\u0642\u0629 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0631\u062d\u0644\u0627\u0646 \u0627\u0644\u0623\u0641\u0642\u064a\u060c \u0648\u062a\u0645 \u0630\u0644\u0643 \u0628\u0627\u0644\u062a\u0632\u0627\u0645\u0646 \u0645\u0639 \u062a\u0631\u062d\u064a\u0644 \u0633\u0644\u0645 \u0639\u064a\u0627\u0631\u064a \u0645\u0646 \u0627\u0644\u062f\u0646\u0627 DNA Ladder 100 bp\u060c \u0638\u064f\u0647\u0650\u0631\u064e\u062a \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0631\u062d\u0644\u0627\u0646 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0651\u0629 \u0628\u0648\u062c\u0648\u062f \u0628\u0631\u0648\u0645\u064a\u062f \u0627\u0644\u0625\u064a\u062a\u064a\u062f\u064a\u0648\u0645 (Euroclone\u060c \u0625\u064a\u0637\u0627\u0644\u064a\u0627) \u0644\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0648\u062c\u0648\u062f \u0639\u0635\u0627\u0628\u0629 \u0648\u062d\u064a\u062f\u0629 \u0648\u0641\u0642 \u0627\u0644\u0637\u0648\u0644 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0644\u0644\u0645\u0646\u062a\u062c\u060c \u0646\u064f\u0642\u064a\u064e\u062a \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0625\u0646\u0632\u064a\u0645\u064a\u0651\u0627\u064b \u062b\u0645\u0651 \u0633\u064f\u0644\u0652\u0633\u0650\u0644\u064e\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0642\u0628\u0644 \u0634\u0631\u0643\u0629 Macrogen\u00ae \u0641\u064a \u0643\u0648\u0631\u064a\u0627 \u0627\u0644\u062c\u0646\u0648\u0628\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0631\u062d\u0644\u0627\u0646 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a \u0627\u0644\u0634\u0639\u0631\u064a (CES) Capilliary Electrophoresis Sequencing \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062c\u0647\u0627\u0632 ABI 3730XL sequencer\u00a0 \u0648\u0639\u062a\u064a\u062f\u0629 \u0627\u0644\u0633\u064e\u0644\u0652\u0633\u064e\u0644\u064e\u0629 ABI BigDye\u2122 Terminator Cycle Sequencing Kit. \u0642\u0645\u0646\u0627 \u0628\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0645\u062c\u064a\u0651\u0629 Geneious \u0644\u0644\u062a\u0623\u0643\u0651\u062f \u0645\u0646 \u062a\u0637\u0627\u0628\u0642 \u0627\u0644\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0644\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629\u060c \u0648\u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0643\u0644\u0651 \u0639\u064a\u0646\u0629.<\/span><\/p>\n

\u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a<\/strong><\/span><\/p>\n

\u062a\u0645 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u062d\u0632\u0645\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0627\u062c\u062a\u0645\u0627\u0639\u064a\u0629\u00a0 SPSS \u0628\u0625\u0635\u062f\u0627\u0631\u0647\u0627 26\u060c \u062a\u0645\u0651 \u0627\u0644\u062a\u062d\u0642\u0651\u0642 \u0623\u0646 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0645\u062d\u0642\u0651\u0642\u0629 \u0644\u0645\u0639\u0627\u062f\u0644\u0629 \u0647\u0627\u0631\u062f\u064a \u0648\u0627\u064a\u0646\u0628\u064a\u0631\u063aHardy Weinberg Equilibrium (HWE) \u0648\u0627\u0639\u062a\u064f\u0645\u0650\u062f\u064e \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0645\u0631\u0628\u0639 \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0645\u064f\u0633\u062a\u064e\u0639\u0631\u064e\u0641 \u0648\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0645\u062a\u0648\u0642\u0639. \u062f\u064f\u0631\u0650\u0633\u064e\u062a \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0644\u0627\u062c\u064a\u0646\u064a\u0651\u0629 \u0645\u0639 \u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646. \u0648\u0627\u0639\u062a\u064f\u0645\u0650\u062f\u064e\u062a \u0642\u064a\u0645\u0629 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 p-value < 0.05 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u0645\u064f\u0637\u0628\u0651\u0642\u0629.<\/span><\/p>\n

\u0627\u0644\u062c\u062f\u0648\u0644 (1): \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u0645\u0639\u062a\u064e\u0645\u064e\u062f\u0629 \u0644\u0625\u062c\u0631\u0627\u0621 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0640 PCR \u0627\u0644\u062e\u0627\u0635\u0651\u0629 \u0628\u0627\u0644\u0643\u0634\u0641 \u0639\u0646 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f 521T>C \u0641\u064a \u062c\u064a\u0646 SLCO1B1<\/em><\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n
\u0627\u0644\u062e\u0637\u0648\u0629 Step<\/span><\/td>\n\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u00a0Temperature (C\u2070)<\/span><\/td>\n\u0627\u0644\u0645\u062f\u0629 Duration<\/span><\/td>\n<\/tr>\n
\u062a\u0645\u0633\u0651\u062e \u0628\u062f\u0626\u064a Initial Denaturation<\/span><\/td>\n96<\/span><\/td>\n\u00a010 \u062f\u0642\u0627\u0626\u0642<\/span><\/td>\n<\/tr>\n
35 \u062f\u0648\u0631\u0629<\/span><\/td>\n\u062a\u0645\u0633\u0651\u062e Denaturation<\/span><\/td>\n96<\/span><\/td>\n\u00a030 \u062b\u0627\u0646\u064a\u0629<\/span><\/td>\n<\/tr>\n
\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0645\u064f\u0631\u064e\u0626\u0650\u0633\u0627\u062a \u0628\u0627\u0644\u062a\u0633\u064e\u0644\u0652\u0633\u064f\u0644\u0627\u062a \u0627\u0644\u0645\u062a\u0645\u0645\u0629<\/span><\/p>\n

Primer Annealing<\/span><\/td>\n

56<\/span><\/td>\n30 \u062b\u0627\u0646\u064a\u0629<\/span><\/td>\n<\/tr>\n
\u0627\u0633\u062a\u0637\u0627\u0644\u0629 Elongation<\/span><\/td>\n72<\/span><\/td>\n1 \u062f\u0642\u064a\u0642\u0629<\/span><\/td>\n<\/tr>\n
\u0627\u0633\u062a\u0637\u0627\u0644\u0629 \u0646\u0647\u0627\u0626\u064a\u0629 Final Elongation<\/span><\/td>\n72\u00b0<\/span><\/td>\n10 \u062f\u0642\u0627\u0626\u0642<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0627\u0644\u0646\u062a\u0627\u0626\u062c<\/strong>\u00a0<\/span><\/p>\n

\u0633\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong>\u00a0<\/span><\/p>\n

\u0642\u0645\u0646\u0627 \u0628\u063a\u0631\u0628\u0644\u0629 34776 \u0642\u064a\u0645\u0629 \u0645\u062e\u0628\u0631\u064a\u0651\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 \u0643\u0631\u064a\u0627\u062a\u064a\u0646 \u0643\u064a\u0646\u0627\u0632 CK \u0645\u062c\u0631\u0627\u0629 \u0644\u0640 12217 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0646 \u0633\u062c\u0644\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0651\u0629 \u0644\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0623\u0633\u062f \u0627\u0644\u062c\u0627\u0645\u0639\u064a \u0641\u064a \u062f\u0645\u0634\u0642 \u0648\u0627\u0644\u0645\u064f\u062c\u0631\u0627\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0648\u0627\u0642\u0639\u0629 \u0628\u064a\u0646 1\\1\\2019 \u064819\\8\\2021. \u0627\u0633\u062a\u064f\u0628\u0639\u0650\u062f\u064e \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0643\u0627\u0646\u062a \u0642\u064a\u0645 \u0625\u0646\u0632\u064a\u0645 CK \u0637\u0628\u064a\u0639\u064a\u0651\u0629 \u0644\u062f\u064a\u0647\u0645\u060c \u062b\u0645\u0651 \u0627\u0633\u062a\u064f\u0628\u0639\u0650\u062f\u064e \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u0646\u0648\u0627 \u0627\u0631\u062a\u0641\u0627\u0639\u0627\u064b \u0641\u064a \u0642\u064a\u0645 CK \u0645\u0642\u062a\u0631\u0646\u0627\u064b \u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u0641\u064a \u0642\u064a\u0645 \u0627\u0644\u0646\u0638\u064a\u0631 \u0627\u0644\u0642\u0644\u0628\u064a \u0644\u0625\u0646\u0632\u064a\u0645 \u0643\u0631\u064a\u0627\u062a\u064a\u0646 \u0643\u064a\u0646\u0627\u0632 CKMB\u060c \u0623\u0648 \u0627\u0631\u062a\u0641\u0627\u0639 \u0641\u064a \u0642\u064a\u0645 \u0627\u0644\u062a\u0631\u0628\u0648\u0646\u064a\u0646Troponin. \u0646\u062a\u062c \u0639\u0646 \u0627\u0633\u062a\u0642\u0635\u0627\u0621 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062adata screening \u00a0130 \u0646\u062a\u064a\u062c\u0629 \u062a\u0639\u0648\u062f \u0644\u0645\u0631\u0636\u0649 \u0639\u0627\u0646\u0648\u0627 \u0627\u0631\u062a\u0641\u0627\u0639\u0627\u064b \u0641\u064a \u0642\u064a\u0645 CK \u063a\u064a\u0631 \u0645\u0641\u0633\u0651\u0631\u0629 \u0644\u0639\u062f\u0645 \u062a\u0631\u0627\u0641\u0642\u0647\u0627 \u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u0641\u064a \u0623\u064a \u0645\u0646 CKMB \u0623\u0648 \u0627\u0644\u062a\u0631\u0628\u0648\u0646\u064a\u0646. \u0623\u062a\u0628\u0639\u0646\u0627 \u0630\u0644\u0643 \u0628\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0633\u062c\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0651\u0629 \u0627\u0644\u062e\u0627\u0635\u0651\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u062d\u0642\u0642\u0648\u0627 CK \u0643\u0644\u064a \u0645\u0631\u062a\u0641\u0639\u060c \u062a\u0631\u0648\u0628\u0648\u0646\u064a\u0646 \u0633\u0644\u0628\u064a\u060c \u0648CKMB \u0645\u0646\u062e\u0641\u0636\u060c \u0644\u062a\u0648\u0635\u064a\u0641 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0648\u0627\u0644\u062a\u0648\u0627\u0635\u0644 \u0645\u0639\u0647\u0645 \u0641\u064a \u062d\u0627\u0644 \u062a\u062d\u0642\u064a\u0642\u0647\u0645 \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 \u0627\u0644\u0623\u062e\u0631\u0649 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a. \u062d\u0642\u0651\u0642 55 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0639\u0627\u064a\u064a\u0631\u00a0 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 \u0636\u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a\u060c \u0648\u062a\u0645\u0651 \u0627\u0644\u062a\u0648\u0627\u0635\u0644 \u0645\u0639\u0647\u0645 \u062c\u0645\u064a\u0639\u0627\u064b. \u0634\u0645\u0644\u064e\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 13 \u0645\u0631\u064a\u0636\u0627\u064b \u0639\u0627\u0646\u0648\u0627 \u0627\u0639\u062a\u0644\u0627\u0644\u0627\u064b \u0639\u0636\u0644\u064a\u0651\u0627\u064b \u0645\u064f\u062d\u0631\u0651\u064e\u0636\u0627\u064b \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u062a\u0631\u0627\u0641\u0642 \u0630\u0644\u0643 \u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u0642\u064a\u0645 \u0625\u0646\u0632\u064a\u0645 CK \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629\u060c \u0641\u064a \u062d\u064a\u0646 \u0644\u0645 \u0646\u062a\u0645\u0643\u0651\u0646 \u0645\u0646 \u062a\u0636\u0645\u064a\u0646 \u0628\u0627\u0642\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u0639\u062f\u0651\u0629 \u0623\u0633\u0628\u0627\u0628 \u062a\u0634\u0645\u0644 (\u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u062a\u0648\u0627\u0635\u0644 \u0648\u0639\u062f\u0645 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0639\u062a\u064a\u0627\u0646 \u0648\u0631\u0641\u0636 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0648\u0627\u0644\u0648\u0641\u0627\u0629) \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u0651\u062d \u0641\u064a \u0627\u0644\u0634\u0643\u0644 (1). \u0648\u0645\u0646 \u062c\u0647\u0629 \u0623\u062e\u0631\u0649 \u0642\u0645\u0646\u0627 \u0628\u0645\u0642\u0627\u0628\u0644\u0629 13 \u0645\u0631\u064a\u0636\u0627\u064b \u0636\u0645\u0646 \u0627\u0644\u0639\u064a\u0627\u062f\u0627\u062a \u0627\u0644\u062e\u0627\u0635\u0651\u0629 \u0645\u0645\u0651\u0646 \u0639\u0627\u0646\u0648\u0627 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0639\u0636\u0644\u064a\u0651\u0629 \u0636\u0627\u0631\u0651\u0629 \u0645\u064f\u062d\u0631\u0651\u064e\u0636\u0629 \u0628\u0627\u0644\u062a\u062f\u0627\u0648\u064a \u00a0\u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u062f\u0648\u0646 \u0623\u0646 \u062a\u062a\u0631\u0627\u0641\u0642\u00a0 \u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u0642\u064a\u0645 CK.<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u0627\u0644\u0634\u0643\u0644 1. \u0645\u062e\u0637\u0637 \u0645\u062c\u0631\u064a\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0641\u0642\u0627\u064b \u0644\u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0625\u0628\u0644\u0627\u063a \u0639\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0631\u0635\u062f\u064a\u0629 \u0641\u064a \u0639\u0644\u0645 \u0627\u0644\u0623\u0648\u0628\u0626\u0629 STROBE (Strengthening the Reporting of \u00a0Observational studies in Epidemiology)<\/strong><\/span><\/p>\n

\u0648\u0627\u0641\u0642 13 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0646\u0647\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u062d\u064a\u0646 \u0631\u0641\u0636 \u062b\u0644\u0627\u062b\u0629 \u0645\u0631\u0636\u0649. \u0628\u0644\u063a \u0645\u062c\u0645\u0648\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a 26 \u0645\u0631\u064a\u0636\u0627\u064b (13 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0646\u0647\u0645 \u0644\u062f\u064a\u0647\u0645 \u0627\u0631\u062a\u0641\u0627\u0639 \u0641\u064a \u0642\u064a\u0645 \u0627\u0644\u0640 CK \u00a0\u0648 13 \u0645\u0631\u064a\u0636\u0627\u064b \u0644\u062f\u064a\u0647\u0645 \u0642\u064a\u0645 CK \u0637\u0628\u064a\u0639\u064a\u0651\u0629 \u0623\u0648 \u063a\u064a\u0631 \u0645\u062d\u062f\u0651\u062f\u0629). \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f: \u0623\u062c\u0631\u064a\u0646\u0627 \u0645\u0642\u0627\u0628\u0644\u0627\u062a \u0645\u0639 63 \u0645\u0631\u064a\u0636\u0627\u064b \u0636\u0645\u0646 \u0627\u0644\u0639\u064a\u0627\u062f\u0627\u062a \u0627\u0644\u062e\u0627\u0635\u0651\u0629\u060c \u0645\u0645\u0646 \u064a\u062a\u062f\u0627\u0648\u0648\u0646 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u062f\u0648\u0646 \u0623\u0646 \u064a\u0639\u0627\u0646\u0648\u0627 \u0623\u064a \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0639\u0636\u0644\u064a\u0651\u0629 \u0636\u0627\u0631\u0651\u0629\u060c \u0648\u0627\u0641\u0642 41 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0646\u0647\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/span><\/p>\n

\u062a\u0648\u0635\u064a\u0641 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n

\u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0639\u0645\u0627\u0631 \u0645\u062c\u0645\u0644 \u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u064a\u0646 19 \u064884 \u0633\u0646\u0629\u060c \u0648\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0639\u0645\u0631\u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064aSD \u00a0(54.31 \u00b113.2) \u0639\u0627\u0645\u0627\u064b.\u0648\u0634\u0643\u0651\u0644 \u0627\u0644\u0630\u0643\u0648\u0631 \u0646\u0633\u0628\u0629 (73%) \u0645\u0646 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0641\u064a \u062d\u064a\u0646 \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 (63%) \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u062a\u0636\u0645\u0646\u064a\u0646 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0646 \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646\u060c \u0648\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u0642\u064a\u0645 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 BMI \u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a (27.8 \u00b14.35) \u0643\u063a\/\u06452 <\/sup>\u00a0\u0648\u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (2) \u062a\u0648\u0635\u064a\u0641 \u0643\u0644 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u0639\u0645\u0631 \u0648\u0627\u0644\u062c\u0646\u0633 \u0648\u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0648\u0642\u064a\u0645 \u0627\u0644\u0640 BMI\u060c \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0648\u0627\u0631\u0642 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 (\u0628\u0642\u064a\u0645 p value \u062a\u0633\u0627\u0648\u064a 0.852 \u06480.577 \u00a0\u06480.087 \u0648 0.346\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628).<\/span><\/p>\n

\u0627\u0644\u062c\u062f\u0648\u0644 (<\/strong>2<\/strong>): \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0651\u0629 \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n
\u00a0<\/strong><\/span><\/td>\n\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a (n=26)<\/strong><\/span><\/td>\n\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f (n=41)<\/strong><\/span><\/td>\np-Value<\/strong><\/span><\/td>\n<\/tr>\n
\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0639\u0645\u0631 \u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a (\u0639\u0627\u0645\u0627\u064b)<\/strong><\/span><\/td>\n(57.8 \u00b113.3)<\/strong><\/span><\/td>\n(52.1 \u00b112.7) <\/strong><\/span><\/td>\n0.852<\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u062c\u0646\u0633<\/strong><\/span><\/p>\n

n (%)<\/strong><\/span><\/td>\n

\u0627\u0644\u0630\u0643\u0648\u0631<\/strong><\/span><\/td>\n\u00a020 (%76.9)<\/strong><\/span><\/td>\n(%70.7) 29<\/strong><\/span><\/td>\n0.577<\/strong><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0625\u0646\u0627\u062b<\/strong><\/span><\/td>\n\u00a0(%23.1) 6<\/strong><\/span><\/td>\n(%29.3) 12<\/strong><\/span><\/td>\n<\/tr>\n
\u0639\u062f\u062f \u0648\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646 \u00a0n (%)<\/strong><\/span><\/td>\n(%50) 13<\/strong><\/span><\/td>\n(%70.7) 29<\/strong><\/span><\/td>\n0.087<\/strong><\/span><\/td>\n<\/tr>\n
\u0645\u062a\u0648\u0633\u0637 \u0642\u064a\u0645 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 BMI \u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a ( \u0643\u063a\/\u06452)<\/strong><\/span><\/td>\n(28.5 \u00b14.93) <\/strong><\/span><\/td>\n(27.5 \u00b13.76) <\/strong><\/span><\/td>\n0.346<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n

\u062a\u0642\u064a\u0651\u064a\u0645 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0644\u0627\u062c\u064a\u0646\u064a\u0651\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/strong><\/span><\/p>\n

\u0644\u0645 \u0646\u062c\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0628\u064a\u0646 \u0643\u0644\u0651 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 \u0648\u0627\u0644\u062c\u0646\u0633 \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0642\u064a\u0645 \u0627\u0644\u0640 BMI \u0648\u062d\u062f\u0648\u062b \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a\u0651\u0629 \u0627\u0644\u0636\u0627\u0631\u0651\u0629\u060c \u062d\u064a\u062b \u0628\u0644\u063a\u062a \u0642\u064a\u0645 p-Values \u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u062c\u0646\u0633 \u0648\u0642\u064a\u0645 \u0627\u0644\u0640 BMI \u0628\u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u062d\u062f\u0648\u062b \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a\u0651\u0629 \u0627\u0644\u0636\u0627\u0631\u0651\u0629: 0.577 \u06480.18 \u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628. \u0641\u064a \u062d\u064a\u0646 \u0628\u0631\u0632\u062a \u0646\u0632\u0639\u0629 \u0644\u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0645\u0639\u062a\u062f \u0628\u0647\u0627 \u0644\u062f\u0649 \u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0632\u062f\u064a\u0627\u062f \u0627\u0644\u0639\u0645\u0631 \u0645\u0639 \u062d\u062f\u0648\u062b \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a\u0651\u0629 \u0627\u0644\u0636\u0627\u0631\u0651\u0629 \u0628\u0642\u064a\u0645\u0629 p value \u00a0\u0645\u0633\u0627\u0648\u064a\u0629 \u0644\u0640 0.087.<\/span><\/p>\n

\u062a\u0642\u064a\u0651\u064a\u0645 \u062c\u0631\u0639\u0629 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0641\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/strong><\/span><\/p>\n

\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u062c\u0631\u0639\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646 (35.34 \u00b110.478) \u0645\u063a \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0645\u062a\u0648\u0633\u0637 \u062c\u0631\u0639\u0629 \u0623\u062e\u0641\u0636 \u0648\u0642\u062f\u0631\u0647\u0627 (31.92 \u00b115.237) \u0645\u063a \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0628\u0641\u0627\u0631\u0642 \u063a\u064a\u0631 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (p=0.28).<\/span><\/p>\n

\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062a\u062f\u0627\u062e\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0651\u0629 \u0641\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/strong><\/span><\/p>\n

\u0644\u062f\u0649 \u062d\u0633\u0627\u0628 \u0639\u062f\u062f \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u062a\u062f\u0627\u062e\u0644\u0627\u062a \u0627\u0644\u0645\u064f\u062d\u062a\u0645\u0644\u064e\u0629 \u0645\u0639 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0627\u0644\u062a\u064a \u064a\u062a\u0646\u0627\u0648\u0644\u0647\u0627 \u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u0639\u062f\u062f \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 (1.08 \u00b11.164) \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u0646\u0648\u0627 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0639\u0636\u0644\u064a\u0651\u0629 \u0636\u0627\u0631\u0651\u0629 \u0633\u0648\u0627\u0621 \u062a\u0631\u0627\u0641\u0642\u062a \u0623\u0645 \u0644\u0645 \u062a\u062a\u0631\u0627\u0641\u0642 \u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u0642\u064a \u062a\u0631\u0627\u0643\u064a\u0632 \u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0640 CK\u060c \u0641\u064a \u062d\u064a\u0646 \u0628\u0644\u063a \u0627\u0644\u0645\u062a\u0648\u0633\u0637 (0.78 \u00b10.988( \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0645 \u064a\u0639\u0627\u0646\u0648\u0627 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0639\u0636\u0644\u064a\u0651\u0629 \u0636\u0627\u0631\u0651\u0629\u060c \u0648\u0630\u0644\u0643 \u0628\u0641\u0627\u0631\u0642 \u063a\u064a\u0631 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (p=0.268). \u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u0639\u0627\u0644\u062c\u064a\u0646 \u0628\u062f\u0648\u0627\u0621 \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u064a\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 50.7% \u0645\u0646 \u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/span><\/p>\n

\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0648\u0627\u0644\u062a\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a<\/strong><\/span><\/p>\n

\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u0645\u0639\u0632\u0648\u0644 (60.8 \u00b124.21) \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0643\u0644. \u0648\u0644\u062f\u0649 \u062a\u0631\u062d\u064a\u0644 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u062a\u0633\u0644\u0633\u0644\u064a \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0627\u0644\u0623\u063a\u0627\u0631\u0648\u0632 \u0644\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0646\u062c\u0627\u062d \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0638\u0647\u0631 \u0645\u0646\u062a\u062c \u0628\u0627\u0644\u0637\u0648\u0644 \u0627\u0644\u0645\u062a\u0648\u0642\u0651\u0639 (328 \u0632\u0648\u062c \u0623\u0633\u0627\u0633)\u060c \u0643\u0645\u0627 \u0647\u0648 \u0645\u0628\u064a\u0651\u0646 \u0641\u064a \u0627\u0644\u0634\u0643\u0644 (2a). \u0643\u0627\u0646 \u0643\u0644\u0651\u064c \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0634\u0627\u0626\u0639Wild \u00a0Type \u00a0(TT) \u0648\u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a (TC) \u0627\u0644\u0623\u0639\u0644\u0649 \u062a\u0648\u0627\u062a\u0631\u0627\u064b \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 \u0648\u0628\u0646\u0633\u0628\u0629 \u0628\u0644\u063a\u062a 76.1% 20.9,% \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628\u060c \u0641\u064a \u062d\u064a\u0646 \u0644\u0645 \u064a\u062a\u062c\u0627\u0648\u0632 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a(CC) Homozygote \u00a0\u0646\u0633\u0628\u0629 3%. \u064a\u064f\u0645\u062b\u0651\u0644 \u0627\u0644\u0634\u0643\u0644 (b2) \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062b\u0644\u0627\u062b\u0629: \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0634\u0627\u0626\u0639 (TT)\u060c \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a (TC)\u060c \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a(CC) \u060c \u0627\u0644\u062a\u064a \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0633\u064e\u0644\u0652\u0633\u064e\u0644\u064e\u0629 \u0648\u062c\u0648\u062f\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 T521>C \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a Cases group \u0628\u0639\u062f \u0627\u0644\u0633\u064e\u0644\u0652\u0633\u064e\u0644\u064e\u0629 \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0645\u064f\u0631\u064e\u0626\u0650\u0633 \u0627\u0644\u062a\u0642\u062f\u0651\u0645\u064a\u060c \u0641\u064a \u062d\u064a\u0646 \u0627\u0642\u062a\u0635\u0631\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0639\u0644\u0649 \u0627\u0644\u0646\u0645\u0637\u064a\u0646 TT \u0648 TC \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u00a0\u0627\u0644\u0634\u0648\u0627\u0647\u062f controls group\u060c \u0645\u0639 \u063a\u064a\u0627\u0628 \u062a\u0627\u0645\u00a0 \u0644\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a .CC<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u0627\u0644\u0634\u0643\u0644 (2): \u0635\u0648\u0631\u0629 \u0645\u0645\u062b\u0644\u0629 \u0644\u0625\u062d\u062f\u0649 \u0647\u064f\u0644\u0627\u0645\u0627\u062a \u0627\u0644\u0623\u063a\u0627\u0631\u0648\u0632 \u0628\u062a\u0631\u0643\u064a\u0632 1.5% \u0628\u0639\u062f \u062a\u0631\u062d\u064a\u0644 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0636\u062e\u064a\u0645 \u0627\u0644\u0640 <\/strong>PCR<\/strong> \u0628\u0627\u0644\u062a\u0632\u0627\u0645\u0646 \u0645\u0639 \u062a\u0631\u062d\u064a\u0644 \u0633\u0644\u0645 \u0639\u064a\u0627\u0631\u064a\u0651\u0627\u062a <\/strong>DNA<\/strong> (<\/strong>A<\/strong>) \u0648\u0627\u0644\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628\u064a\u0651\u0629 <\/strong>Chromatogram<\/strong> \u00a0\u0644\u062a\u064e\u0633\u064f\u0644\u0652\u0633\u064f\u0644 \u0627\u0644\u062f\u0646\u0627 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 521 \u0641\u064a \u062c\u064a\u0646 <\/strong>SLCO1B1<\/em><\/strong> \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062b\u0644\u0627\u062b\u0629: \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0627\u0644\u0634\u0627\u0626\u0639 <\/strong>Wild Type<\/strong> (<\/strong>TT<\/strong>) \u0648\u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a <\/strong>Heterozygote<\/strong> (<\/strong>TC<\/strong>)\u060c \u0648\u0627\u0644\u0646\u0645\u0637<\/strong> \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a <\/strong>Homozygote<\/strong> (<\/strong>CC<\/strong>) (<\/strong>B<\/strong>)<\/strong><\/span><\/p>\n

\u062a\u0642\u064a\u0651\u064a\u0645 \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0628\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a\u0651\u0629 \u0627\u0644\u0636\u0627\u0631\u0651\u0629 \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636\u0629 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/strong><\/span><\/p>\n

\u062a\u0628\u064a\u0651\u0646 \u0623\u0646\u0651 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a TT\u00a0 \u0643\u0627\u0646 \u0627\u0644\u0623\u0639\u0644\u0649 \u0641\u064a \u0643\u0644\u0651 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f \u0648\u0628\u0646\u0633\u0628\u0629 \u0628\u0644\u063a\u062a 65.4% \u0648 82.9%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 (p=0.19)\u060c \u0641\u064a \u062d\u064a\u0646 \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a TC \u0641\u064a \u0643\u0644\u062a\u0627 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 26.9% \u0648 17.1%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628 \u0648\u0628\u0641\u0627\u0631\u0642 \u063a\u064a\u0631<\/span><\/p>\n

\u0627\u0644\u062c\u062f\u0648\u0644 (3): \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0643\u0644\u064a\u0629 \u0648\u0643\u0644\u0651 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n\n
\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a<\/strong><\/span><\/td>\n\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/td>\n\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a <\/strong><\/span><\/td>\n\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f <\/strong><\/span><\/td>\nP value<\/strong><\/span><\/td>\n<\/tr>\n
TT<\/strong><\/span><\/td>\n\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/span><\/td>\n51 (76.1%)<\/span><\/td>\n17 (65.4%)<\/span><\/td>\n34 (82.9%)<\/span><\/td>\n0.19<\/span><\/td>\n<\/tr>\n
TC<\/strong><\/span><\/td>\n\u0627\u0644\u0639\u062f\u062f<\/strong> (%)<\/strong><\/span><\/td>\n\u00a0\u00a014 (20.9%)<\/span><\/td>\n7 (26.9%)<\/span><\/td>\n7 (17.1%)<\/span><\/td>\n0.545<\/span><\/td>\n<\/tr>\n
CC<\/strong><\/span><\/td>\n\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/span><\/td>\n2 (3%)<\/span><\/td>\n2 (7.7%)<\/span><\/td>\n0 (0%)<\/span><\/td>\n0.026<\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0623\u0644\u0627\u0626\u0644<\/strong><\/span><\/td>\n\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/td>\n\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a<\/strong><\/span><\/td>\n\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f <\/strong><\/span><\/td>\nP value<\/strong><\/span><\/td>\n<\/tr>\n
T<\/strong><\/span><\/td>\n\u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u0629 (%)<\/strong><\/span><\/td>\n86.6%<\/span><\/td>\n78.8%<\/span><\/td>\n91.5%<\/span><\/td>\n0.032<\/span><\/td>\n<\/tr>\n
C<\/strong><\/span><\/td>\n\u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u0629 (%)<\/strong><\/span><\/td>\n13.4%<\/span><\/td>\n21.2%<\/span><\/td>\n8.5%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b\u00a0 \u00a0(p=0.545)\u060c \u0643\u0645\u0627 \u0627\u0646\u0639\u062f\u0645 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a CC \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f \u0648\u0628\u0644\u063a 7.7% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0628\u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (p=0.026). \u0643\u0645\u0627 \u0647\u0648 \u0645\u0628\u064a\u0651\u0646 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (3) .<\/span><\/p>\n

\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629<\/strong>\u00a0<\/span><\/p>\n

\u0628\u0631\u0632\u062a \u0623\u0647\u0645\u064a\u0651\u0629 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0639\u062f\u0651\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0651\u0629 \u0645\u0641\u0631\u062f\u0629 \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0641\u064a \u0640\u062c\u064a\u0646 \u00a0SLCO1B1<\/em>\u0639\u064e\u0642\u0650\u0628\u064e \u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u062f\u0648\u0631 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 OATP1B1 \u0627\u0644\u0630\u064a \u064a\u0631\u0645\u0651\u0632\u0647 \u0641\u064a \u0646\u0642\u0644 \u0648\u0625\u062f\u062e\u0627\u0644 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0631\u064f\u0643\u0627\u0632\u0627\u062a \u062f\u0627\u062e\u0644\u064a\u0651\u0629 \u0648\u062e\u0627\u0631\u062c\u064a\u0651\u0629 \u0627\u0644\u0645\u0646\u0634\u0623 \u0625\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0628\u062f\u064a\u0651\u0629. \u0648\u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0627\u0644\u0628\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u062e\u064e\u0644\u064f\u0635\u064e \u0625\u0644\u064a\u0647\u0627 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629\u060c \u062d\u064e\u0638\u0650\u064a\u064e \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 521T>C \u0641\u064a \u062c\u064a\u0646 SLCO1B1<\/em> \u0627\u0647\u062a\u0645\u0627\u0645 \u0627\u0644\u0647\u064a\u0626\u0627\u062a \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0651\u0629 \u0627\u0644\u0645\u0639\u0646\u064a\u0651\u0629 \u0628\u0648\u0636\u0639 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u0648\u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0625\u0631\u0634\u0627\u062f\u064a\u0651\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0628\u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u060c \u0646\u0638\u0631\u0627\u064b \u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0647\u0630\u0627 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0628\u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u0636 \u0628\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a. \u062d\u064a\u062b \u0623\u0648\u0635\u0649 \u0639\u062f\u062f\u064c \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0647\u064a\u0626\u0627\u062a \u0628\u0636\u0631\u0648\u0631\u0629 \u062a\u0646\u0645\u064a\u0637 \u062c\u064a\u0646 SLCO1B1<\/em> \u0628\u0647\u062f\u0641 \u0634\u062e\u0635\u0646\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0648\u064a\u0623\u062a\u064a \u0639\u0644\u0649 \u0631\u0623\u0633\u0647\u0627 \u0627\u0644\u062a\u062d\u0627\u0644\u0641 \u0627\u0644\u062a\u0646\u0641\u064a\u0630\u064a \u0644\u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u00a0 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u00a0 CPIC \u0648\u0627\u0644\u0634\u0628\u0643\u0629 \u0627\u0644\u0641\u0631\u0646\u0633\u064a\u0629 \u0644\u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a The French National Network of Pharmacogenetics (RNPGX)\u060c \u0648\u062a\u0623\u062a\u064a \u0623\u0647\u0645\u064a\u0651\u0629 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0623\u0646\u0651\u0647\u0627 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0646\u0648\u0639\u0647\u0627 \u0628\u062d\u0633\u0628 \u0639\u0644\u0645\u0646\u0627\u060c 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\u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0641\u064a \u062f\u0648\u0644 \u0634\u0631\u0642 \u0622\u0633\u064a\u0627 \u0645\u062b\u0644 \u0627\u0644\u0635\u064a\u0646 \u0641\u064a \u062f\u0631\u0627\u0633\u0629Qiang Fu \u00a0\u00a0\u0648\u0632\u0645\u0644\u0627\u0626\u0647 (16.2%)37<\/sup> \u0648\u0627\u0644\u064a\u0627\u0628\u0627\u0646 \u0641\u064a \u062f\u0631\u0627\u0633\u0629Nozawa \u00a0\u00a0\u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u00a0(11%) 38<\/sup>\u060c \u0631\u063a\u0645 \u0627\u0644\u062a\u0628\u0627\u0639\u062f \u0639\u0631\u0642\u064a\u0627\u064b \u0628\u064a\u0646 \u062c\u0645\u0647\u0631\u062a\u0646\u0627 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u0634\u0639\u0648\u0628 \u0627\u0644\u0634\u0631\u0642 \u0627\u0644\u0623\u0642\u0635\u0649. \u0648\u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (4) \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0627\u0641\u0631 C \u0644\u062f\u0649 \u0628\u0639\u0636 \u0627\u0644\u062c\u0645\u0647\u0631\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0639\u0631\u0642\u064a\u0651\u0629.<\/span><\/p>\n

\u0635\u0646\u0641\u0646\u0627 \u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062e\u0637\u0648\u0631\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0625\u0644\u0649 \u062b\u0644\u0627\u062b \u0641\u0626\u0627\u062a: \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0648\u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629.<\/span><\/p>\n

\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f <\/strong>521T>C<\/strong> \u0628\u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/strong><\/span><\/p>\n

\u062a\u062d\u0631\u0651\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0641\u064a\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0644\u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0627\u0641\u0631 C \u0641\u064a \u062c\u064a\u0646 SLCO1B1<\/em> \u062f\u0648\u0631\u0627\u064b \u0641\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a\u0651\u0629 \u0627\u0644\u0636\u0627\u0631\u0651\u0629 \u0644\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a\u060c \u0648\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0627\u0641\u0631 C \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0628\u0646\u0633\u0628\u0629 21.2% \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u062a\u0648\u0627\u062a\u0631 \u0644\u0645 \u064a\u062a\u062c\u0627\u0648\u0632 \u0646\u0633\u0628\u0629 .58% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f \u0648\u0628\u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (p=0.032). \u062a\u0624\u064a\u0651\u062f \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0628\u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f 521T>C \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f \u0627\u0646\u062e\u0631\u0627\u0637 \u0627\u0644\u0623\u0644\u064a\u0644 C \u0628\u0627\u062e\u062a\u0637\u0627\u0631 \u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0627\u0641\u0642\u062a \u0646\u062a\u0627\u0626\u062c \u0628\u062d\u062b\u0646\u0627 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062a\u0644\u0648\u064a \u0627\u0644\u0630\u064a \u0623\u062c\u0631\u0627\u0647 Turongkaravee \u0648\u0632\u0645\u0644\u0627\u0624\u064739<\/sup> \u0641\u064a \u0639\u0627\u0645 2021 \u0644\u0640 15 \u062f\u0631\u0627\u0633\u0629 \u0634\u0645\u0644\u062a 4311 \u0641\u0631\u062f\u0627\u064b \u0645\u062a\u062f\u0627\u0648\u064a\u0646 \u0628\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0645\u062a\u0646\u0648\u0639\u0629\u060c \u0648\u0623\u0638\u0647\u0631 \u0623\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062d\u0627\u0645\u0644\u064a\u0646 \u0644\u0644\u0623\u0644\u064a\u0644 C \u0623\u0643\u062b\u0631 \u0639\u0631\u0636\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a\u0651\u0629 \u0627\u0644\u0636\u0627\u0631\u0651\u0629 \u0627\u0644\u0645\u0631\u0627\u0641\u0642\u0629 \u0644\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0628\u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u0636\u0639\u0641 \u0628\u062d\u0627\u0644 \u0648\u062c\u0648\u062f \u0646\u0633\u062e\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0627\u0644\u0623\u0644\u064a\u0644 C\u060c \u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u0627\u0647\u0627\u00a0 Hoste \u0648\u0632\u0645\u0644\u0627\u0624\u064740<\/sup> \u00a0<\/sup>\u0641\u064a \u0639\u0627\u0645 2024 \u0627\u0646\u062e\u0631\u0627\u0637 \u0627\u0644\u0623\u0644\u064a\u0644 C \u0641\u064a \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a\u0651\u0629 \u0627\u0644\u0636\u0627\u0631\u0651\u0629 \u0627\u0644\u0645\u0631\u0627\u0641\u0642\u0629 \u0644\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646.<\/span><\/p>\n

\u0627\u0644\u062c\u062f\u0648\u0644 (4): \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0627\u0641\u0631 C \u0644\u062f\u0649 \u0628\u0639\u0636 \u0627\u0644\u062c\u0645\u0647\u0631\u0627\u062a \u0627\u0644\u0633\u0651\u064f\u0643\u0627\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0639\u0631\u0642\u064a\u0651\u0629 \u0641\u064a \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0639\u0631\u0628\u064a\u0651\u0629 \u0648\u0627\u0644\u0639\u0627\u0644\u0645<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0639\u0631\u0642\u064a\u0651\u0629<\/strong><\/span><\/td>\n\u062d\u062c\u0645 \u0627\u0644\u062c\u0645\u0647\u0631\u0629<\/strong><\/span><\/td>\n\u0627\u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629<\/strong><\/span><\/td>\n\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 <\/strong>C<\/strong><\/span><\/td>\nP value<\/strong><\/span><\/td>\n\u0627\u0644\u0645\u0631\u062c\u0639<\/strong><\/span><\/td>\n<\/tr>\n
\u0633\u0648\u0631\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n100<\/span><\/td>\n\u0645\u0631\u0636\u0649 \u0641\u0631\u0637 \u0634\u062d\u0645\u064a\u0627\u062a \u0627\u0644\u062f\u0645 \u0645\u062a\u062f\u0627\u0648\u0648\u0646 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/span><\/td>\n13.4%<\/span><\/td>\n<\/td>\n\u062f\u0631\u0627\u0633\u062a\u0646\u0627<\/span><\/td>\n<\/tr>\n
\u0644\u0628\u0646\u0627\u0646\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n127<\/span><\/td>\n\u0645\u0631\u0636\u0649 \u0627\u0644\u0644\u0648\u0643\u064a\u0645\u064a\u0627 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 \u0627\u0644\u062d\u0627\u062f\u0651\u0629<\/span><\/td>\n14.2%<\/span><\/td>\n0.89<\/span><\/td>\n31<\/sup><\/span><\/td>\n<\/tr>\n
\u0625\u0645\u0627\u0631\u062a\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n100<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621<\/span><\/td>\n18.7%<\/span><\/td>\n0.335<\/span><\/td>\n29<\/sup><\/span><\/td>\n<\/tr>\n
\u0633\u0639\u0648\u062f\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n50<\/span><\/td>\n\u0645\u0631\u0636\u0649 \u0641\u0631\u0637 \u0634\u062d\u0645\u064a\u0627\u062a \u0627\u0644\u062f\u0645<\/span><\/td>\n24%<\/span><\/td>\n0.068<\/span><\/td>\n30<\/sup><\/span><\/td>\n<\/tr>\n
\u0642\u0637\u0631\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n6218<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0633\u0643\u0627\u0646\u064a\u0651\u0629 \u0645\u062a\u0646\u0648\u0639\u0629 \u0625\u0636\u0627\u0641\u0629\u064b \u0625\u0644\u0649 \u0627\u0644\u0642\u0637\u0631\u064a\u0651\u064a\u0646<\/span><\/td>\n32.3%<\/span><\/td>\n0.002<\/span><\/td>\n28<\/sup><\/span><\/td>\n<\/tr>\n
\u0623\u0631\u062f\u0646\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n166<\/span><\/td>\n\u0627\u0644\u0634\u064a\u0634\u0627\u0646 \u0627\u0644\u0642\u0627\u0637\u0646\u0648\u0646 \u0641\u064a \u0627\u0644\u0623\u0631\u062f\u0646<\/span><\/td>\n8%<\/span><\/td>\n0.357<\/span><\/td>\n32<\/sup><\/span><\/td>\n<\/tr>\n
\u062a\u0648\u0646\u0633\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n102<\/span><\/td>\n\u0623\u0637\u0641\u0627\u0644 \u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a<\/span><\/td>\n28%<\/span><\/td>\n0.014<\/span><\/td>\n27<\/sup><\/span><\/td>\n<\/tr>\n
\u0623\u062a\u0631\u0627\u0643<\/strong><\/span><\/td>\n94<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621<\/span><\/td>\n12.2%<\/span><\/td>\n1<\/span><\/td>\n33<\/sup><\/span><\/td>\n<\/tr>\n
\u0623\u0644\u0645\u0627\u0646\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n300<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621<\/span><\/td>\n15%<\/span><\/td>\n0.839<\/span><\/td>\n33<\/sup><\/span><\/td>\n<\/tr>\n
\u062a\u0634\u064a\u0643\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n3294<\/span><\/td>\n\u0645\u0631\u0636\u0649 \u0645\u062a\u062f\u0627\u0648\u0648\u0646 \u0628\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a<\/span><\/td>\n19.9%<\/span><\/td>\n0.253<\/span><\/td>\n34<\/sup><\/span><\/td>\n<\/tr>\n
\u0631\u0648\u0645\u0627\u0646\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n470<\/span><\/td>\n\u0639\u064a\u0651\u0646\u0627\u062a DNA\u0645\u062a\u0646\u0648\u0639\u0629 \u0644\u0645\u0631\u0636\u0649 \u0645\u0646 \u0627\u0644\u0628\u0646\u0643 \u0627\u0644\u062d\u064a\u0648\u064a<\/span><\/td>\n17.2%<\/span><\/td>\n0.553<\/span><\/td>\n16<\/sup><\/span><\/td>\n<\/tr>\n
\u0647\u0646\u063a\u0627\u0631\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n442<\/span><\/td>\n\u0639\u064a\u0651\u0646\u0627\u062a DNA\u0645\u062a\u0646\u0648\u0639\u0629 \u0644\u0645\u0631\u0636\u0649 \u0645\u0646 \u0627\u0644\u0628\u0646\u0643 \u0627\u0644\u062d\u064a\u0648\u064a<\/span><\/td>\n18.9%<\/span><\/td>\n0.335<\/span><\/td>\n16<\/sup><\/span><\/td>\n<\/tr>\n
\u0641\u0646\u0644\u0646\u062f\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n468<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621<\/span><\/td>\n20%<\/span><\/td>\n0.253<\/span><\/td>\n35<\/sup><\/span><\/td>\n<\/tr>\n
\u0635\u064a\u0646\u0646\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n363<\/span><\/td>\n\u0645\u0631\u0636\u0649 \u0641\u0631\u0637 \u0634\u062d\u0645\u064a\u0627\u062a \u0627\u0644\u062f\u0645<\/span><\/td>\n16.2%<\/span><\/td>\n1<\/span><\/td>\n37<\/sup><\/span><\/td>\n<\/tr>\n
\u064a\u0627\u0628\u0627\u0646\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n267<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621<\/span><\/td>\n11%<\/span><\/td>\n0.828<\/span><\/td>\n38<\/sup><\/span><\/td>\n<\/tr>\n
\u0628\u0631\u0627\u0632\u064a\u0644\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n143<\/span><\/td>\n\u0645\u0631\u0636\u0649 \u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0634\u062d\u0645\u064a\u0627\u062a \u0627\u0644\u0639\u0627\u0626\u0644\u064a<\/span><\/td>\n14%<\/span><\/td>\n1<\/span><\/td>\n41<\/sup><\/span><\/td>\n<\/tr>\n
\u0645\u0643\u0633\u064a\u0643\u064a\u0651\u0648\u0646<\/strong><\/span><\/td>\n60<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621<\/span><\/td>\n1.7%<\/span><\/td>\n0.005<\/span><\/td>\n36<\/sup><\/span><\/td>\n<\/tr>\n
\u0623\u0641\u0627\u0631\u0642\u0629<\/strong><\/span><\/td>\n115<\/span><\/td>\n\u0623\u0635\u062d\u0627\u0621<\/span><\/td>\n3.9%<\/span><\/td>\n0.04<\/span><\/td>\n33<\/sup><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\u00a0\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0651\u0629 \u0641\u064a \u062d\u062f\u0648\u062b<\/strong> \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/strong><\/span><\/p>\n

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