{"id":1811,"date":"2024-09-01T13:55:49","date_gmt":"2024-09-01T13:55:49","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=1811"},"modified":"2025-01-06T10:02:40","modified_gmt":"2025-01-06T10:02:40","slug":"%d8%aa%d9%88%d8%a7%d8%aa%d8%b1-%d8%a7%d9%84%d8%aa%d9%91%d8%a3%d8%ab%d9%8a%d8%b1%d8%a7%d8%aa-%d8%a7%d9%84%d8%b6%d9%91%d8%a7%d8%a6%d8%b1%d8%a9-%d9%84%d8%b1%d9%8a%d8%b3%d8%a8%d9%8a%d8%b1%d9%8a%d8%af","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=1811","title":{"rendered":"\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0646\u0641\u0633\u064a\u064a\u0646 \u0633\u0648\u0631\u064a\u064a\u0646"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0642\u062f\u0651\u0645\u0629<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u064f\u0639\u062f \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0645\u0646 \u0627\u0644\u0642\u0636\u0627\u064a\u0627 \u0627\u0644\u0647\u0627\u0645\u0651\u0629 \u0635\u062d\u064a\u0651\u0627\u064b\u060c (1) \u0648\u0627\u0644\u062a\u064a \u0623\u0635\u0628\u062d\u062a \u0645\u0646 \u0645\u0633\u0628\u0651\u0628\u0627\u062a \u0627\u0644\u0639\u062c\u0632 \u0641\u064a \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0651\u0629 \u0639\u0627\u0644\u0645\u064a\u0651\u0627\u064b\u061b (2) \u0641\u0642\u062f \u062a\u062f\u0641\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u062f\u062e\u0648\u0644 \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u064a\u0627\u062a\u061b \u062d\u064a\u062b \u0634\u063a\u0644\u062a \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0636\u0627\u0626\u0631\u0629 5.2% \u0645\u0646 \u0627\u0644\u0642\u0628\u0648\u0644\u0627\u062a \u0627\u0644\u0645\u0634\u0641\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0645\u062a\u062d\u062f\u0629\u060c \u0641\u0636\u0644\u0627\u064b \u0639\u0646 \u0627\u0644\u0639\u0628\u0621 \u0627\u0644\u0627\u0642\u062a\u0635\u0627\u062f\u064a \u0627\u0644\u0645\u062a\u0631\u062a\u0651\u0628 \u0639\u0644\u064a\u0647\u0627\u061b \u062d\u064a\u062b \u0642\u064f\u062f\u0651\u0631\u062a \u0627\u0644\u062a\u0651\u0643\u0644\u0641\u0629 \u0627\u0644\u0633\u0651\u0646\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u062a\u0648\u0642\u0639\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0642\u0628\u0648\u0644\u0627\u062a \ufe92 466 \u0645\u0644\u064a\u0648\u0646 \u062c\u0646\u064a\u0647 \u0625\u0633\u062a\u0631\u0644\u064a\u0646\u064a. 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(10) \u064a\u064f\u0639\u062f\u0651 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0645\u0646 \u0623\u0634\u064a\u0639 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u062b\u0627\u0646\u064a\u060c (11) \u0648\u0642\u062f \u062d\u0627\u0632 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0651\u0629 Food and Drug Administration (FDA) \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0641\u0635\u0627\u0645 \u0644\u062f\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0648\u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0628\u0623\u0639\u0645\u0627\u0631\u064d \u062a\u0632\u064a\u062f \u0639\u0646 13 \u0639\u0627\u0645\u0627\u064b\u060c \u0648\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0639\u0644\u0627\u062c\u0627\u064b \u0645\u0641\u0631\u062f\u0627\u064b \u0641\u064a \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0627\u0636\u0637\u0631\u0627\u0628 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0642\u0637\u0628 Bipolar I \u0644\u062f\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0648\u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0628\u0623\u0639\u0645\u0627\u0631 \u062a\u0632\u064a\u062f \u0639\u0646 \u0627\u0644\u0639\u0634\u0631\u0629 \u0623\u0639\u0648\u0627\u0645\u060c \u0623\u0648 \u0639\u0644\u0627\u062c\u0627\u064b \u0645\u0633\u0627\u0639\u062f\u0627\u064b \u0645\u0639 \u0627\u0644\u0644\u064a\u062b\u064a\u0648\u0645 \u0623\u0648 \u0627\u0644\u0641\u0627\u0644\u0628\u0631\u0648\u0627\u062a \u0644\u062f\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646\u060c \u0648\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u064a\u0627\u062c irritability \u00a0\u0627\u0644\u0645\u064f\u0631\u0627\u0641\u0642 \u0644\u0637\u064a\u0641 \u0627\u0644\u062a\u0648\u062d\u062f \u0644\u062f\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0628\u0623\u0639\u0645\u0627\u0631 \u062a\u0632\u064a\u062f \u0639\u0646 \u0627\u0644\u062e\u0645\u0633\u0629 \u0623\u0639\u0648\u0627\u0645. \u064a\u064f\u0644\u0627\u062d\u0638 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0630\u0647\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u0627\u0641\u0642\u0629 \u0644\u0639\u062f\u0629 \u0623\u0645\u0631\u0627\u0636 \u0645\u062b\u0644 \u0627\u0644\u0627\u0643\u062a\u0626\u0627\u0628 \u0623\u0648 \u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0634\u0651\u062e\u0635\u064a\u0651\u0629 \u0627\u0644\u062d\u062f\u064a\u0651\u0629 borderline personality \u0648\u0645\u062a\u0644\u0627\u0632\u0645\u0629 Tourette \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0627\u0633\u062a\u0637\u0628\u0627\u0628\u0627\u062a \u063a\u064a\u0631 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\u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0651\u0629 \u0644\u0644\u0637\u0628 \u0627\u0644\u0646\u0641\u0633\u064a \u0644\u0644\u0623\u0637\u0641\u0627\u0644 \u0648\u0627\u0644\u064a\u0627\u0641\u0639\u064a\u0646 American Academy of Child and Adolescent Psychiatry \u0625\u0644\u0649 \u0623\u0646\u0651 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0644\u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0630\u0647\u0627\u0646 \u0645\u062a\u0634\u0627\u0628\u0647\u0629 \u0641\u064a \u0645\u0627\u0647\u064a\u0651\u062a\u0647\u0627 \u0644\u062f\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0648\u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646.(11) \u00a0\u064a\u062e\u0636\u0639 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0644\u0627\u0633\u062a\u062d\u0627\u0644\u0629 \u062d\u064a\u0648\u064a\u0651\u0629 biotransformation \u0641\u064a \u0627\u0644\u0643\u0628\u062f\u060c \u062a\u062d\u0648\u0651\u0644\u0647 \u0645\u0646 \u0645\u0631\u0643\u0628 \u063a\u064a\u0631 \u0642\u0637\u0628\u064a\u0651 (\u0645\u0646\u062d\u0644\u0651 \u0628\u0627\u0644\u062f\u0651\u0633\u0645) \u0625\u0644\u0649 \u0645\u0633\u062a\u0642\u0644\u0628 \u0642\u0637\u0628\u064a\u0651 (\u0645\u0646\u062d\u0644\u0651 \u0628\u0627\u0644\u0645\u0627\u0621) \u0645\u0645\u0651\u0627 \u064a\u0633\u0627\u0639\u062f \u0641\u064a \u0637\u0631\u062d\u0647 \u062e\u0627\u0631\u062c \u0627\u0644\u062c\u0633\u0645\u061b \u062d\u064a\u062b \u064a\u062e\u0636\u0639 \u0641\u064a \u0627\u0644\u0643\u0628\u062f \u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0637\u0651\u0648\u0631 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062a\u064a \u062a\u062a\u0648\u0627\u0633\u0637\u0647\u0627 \u0628\u0635\u0648\u0631\u0629 \u0631\u0626\u064a\u0633\u064a\u0651\u0629 \u0625\u0646\u0632\u064a\u0645\u0627\u062a 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(13) \u064a\u062a\u0639\u0631\u0651\u0636 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0644\u0639\u0645\u0644\u064a\u0629 \u0647\u062f\u0631\u0643\u0633\u0644\u0629 \u0641\u064a \u0627\u0644\u0645\u0648\u0636\u0639 9\u060c \u0648\u064a\u062a\u062d\u0648\u0644 \u0628\u0646\u062a\u064a\u062c\u062a\u0647\u0627 \u0625\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0628 \u0627\u0644\u0641\u0639\u0651\u0627\u0644 9-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 9-hydroxy Risperidone (\u0627\u0644\u0645\u0633\u0648\u0651\u0642 \u0628\u0627\u0633\u0645 Paliperidone \u0648\u0627\u0644\u0645\u0643\u0627\u0641\u0626 \u0644\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646) \u0628\u0634\u0643\u0644 \u0623\u0639\u0638\u0645\u064a \u0628\u062a\u0648\u0627\u0633\u0637 \u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0648\u0628\u062f\u0631\u062c\u0629 \u0623\u0642\u0644 \u0628\u062a\u0648\u0627\u0633\u0637 \u0625\u0646\u0632\u064a\u0645\u0627\u062a CYP3A4 \u0648CYP3A5. (14) \u062a\u0632\u062f\u0627\u062f \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0651\u0629 \u062d\u062f\u0648\u062b \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0644\u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0630\u0651\u0647\u0627\u0646 \u0628\u0633\u0628\u0628 \u0627\u0644\u062a\u0651\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0651\u0629\u060c \u0641\u0642\u062f \u0623\u0634\u0627\u0631\u062a \u062c\u0645\u0639\u064a\u0651\u0629 \u0639\u0644\u0645 \u0627\u0644\u0646\u0651\u0641\u0633 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0651\u0629 American Psychiatric Association \u0641\u064a \u062f\u0644\u064a\u0644\u0647\u0627 \u0627\u0644\u0625\u0631\u0634\u0627\u062f\u064a \u0627\u0644\u0645\u0646\u0634\u0648\u0631 \u0639\u0627\u0645 2020 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0641\u0635\u0627\u0645 \u0625\u0644\u0649 \u0636\u0631\u0648\u0631\u0629 \u0627\u0644\u062d\u0630\u0631 \u0645\u0646 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0628\u064a\u0646 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0630\u0647\u0627\u0646 \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0648\u0635\u0648\u0641\u0629. (15) \u0642\u062f \u062a\u0643\u0648\u0646 \u0647\u0630\u0647 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628\u061b \u062d\u064a\u062b \u062a\u0639\u0645\u0644 \u0645\u062b\u0628\u0637\u0627\u062a CYP2D6 \u0639\u0644\u0649 \u062a\u062b\u0628\u0637 \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a\u0647 \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629\u060c \u0627\u0644\u0623\u0645\u0631 \u0627\u0644\u0630\u064a \u064a\u0632\u064a\u062f \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u062a\u0623\u062b\u064a\u0631\u0627\u062a\u0647 \u0627\u0644\u0636\u0627\u0626\u0631\u0629. (16) \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u062a\u0624\u062f\u064a \u0645\u0634\u0627\u0631\u0643\u062a\u0647 \u0645\u0639 \u0645\u062d\u0631\u0636\u0627\u062a CYP3A4 \u0645\u062b\u0644 \u0643\u0627\u0631\u0628\u0627\u0645\u0627\u0632\u064a\u0628\u064a\u0646 \u0625\u0644\u0649 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a\u0647 \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0628\u0633\u0628\u0628 \u0632\u064a\u0627\u062f\u0629 \u0627\u0633\u062a\u0642\u0644\u0627\u0628\u0647. \u00a0(17)\u0646\u0638\u0631\u0627\u064b \u0644\u0642\u0644\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629 \u0639\u0627\u0644\u0645\u064a\u0651\u0627\u064b \u0628\u062e\u0635\u0648\u0635 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0648\u0646\u062f\u0631\u062a\u0647\u0627 \u0641\u064a \u0633\u0648\u0631\u064a\u0651\u0629\u060c \u0647\u062f\u0641\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0625\u0644\u0649 \u062a\u062d\u0631\u0651\u064a \u0645\u0627\u0647\u064a\u0651\u0629 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0648\u062a\u0648\u0627\u062a\u0631\u0647\u0627 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0633\u0648\u0631\u064a\u064a\u0646 \u0648\u062a\u0642\u064a\u064a\u0645 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0644\u0627\u062c\u064a\u0646\u064a\u0629 \u0641\u064a \u0632\u064a\u0627\u062f\u0629 \u062d\u062f\u0648\u062b\u0647\u0627.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f\u0651 \u0648\u0627\u0644\u0637\u0651\u0631\u0627\u0626\u0642<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u0635\u0645\u064a\u0645 \u0648\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0635\u064f\u0645\u0645\u062a \u062f\u0631\u0627\u0633\u0627\u062a\u0646\u0627 \u0644\u062a\u0643\u0648\u0646 \u062f\u0631\u0627\u0633\u0629 \u0645\u0642\u0637\u0639\u064a\u0651\u0629-\u0645\u0633\u062a\u0639\u0631\u0636\u0629 cross-sectional study \u0636\u0645\u0646\u062a \u0623\u0641\u0631\u0627\u062f\u0627\u064b \u064a\u062a\u0644\u0642\u0648\u0646 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0641\u064a \u0639\u062f\u062f\u064d \u0645\u0646 \u0627\u0644\u0645\u0624\u0633\u0633\u0627\u062a \u0627\u0644\u0635\u062d\u064a\u0629 \u0634\u0645\u0644\u062a \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0645\u0648\u0627\u0633\u0627\u0629 \u0627\u0644\u062c\u0627\u0645\u0639\u064a\u060c \u0648\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0628\u0646 \u0631\u0634\u062f \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0646\u0641\u0633\u064a\u0629\u060c \u0648\u0639\u062f\u062f \u0645\u0646 \u0627\u0644\u0639\u064a\u0627\u062f\u0627\u062a \u0627\u0644\u0646\u0651\u0641\u0633\u064a\u0651\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0641\u064a \u062f\u0645\u0634\u0642\u060c \u0648\u0633\u062c\u0651\u0644\u062a \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0648\u0635\u0646\u0651\u0641\u062a \u062d\u0633\u0628 \u0645\u0642\u0627\u064a\u064a\u0633 \u0645\u064f\u0639\u062a\u0645\u062f\u0629 \u0639\u0627\u0644\u0645\u064a\u0651\u0627\u064b \u062a\u0642\u064a\u0651\u0645 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0639\u0645\u0648\u0645\u0627\u064b \u0645\u062b\u0644 UKU \u0648\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629 \u062e\u0635\u0648\u0635\u0627\u064b \u0645\u062b\u0644 SAS\u060c \u0648\u0630\u0644\u0643 \u0628\u0639\u062f \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0634\u0631\u0648\u062d\u0627\u062a \u0627\u0644\u0648\u0627\u0641\u064a\u0629 \u0644\u0647\u0645 \u062d\u0648\u0644 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0627\u062a\u0647\u0645 \u0627\u0644\u0645\u0633\u062a\u0646\u064a\u0631\u0629. \u062d\u0638\u064a\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u062a\u064a \u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0629 \u0628\u062a\u0627\u0631\u064a\u062e 4\/1\/2022 \u0648\u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 29\/1\/2022\u060c \u0648\u0623\u064f\u062c\u0631\u064a\u062a \u0641\u064a \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0651\u0629 \u0628\u064a\u0646 \u0634\u0628\u0627\u0637 2022 \u0648\u062a\u0634\u0631\u064a\u0646 \u0627\u0644\u062b\u0627\u0646\u064a 2023. \u0634\u0645\u0644\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 \u0645\u0631\u0636\u0649 \u0645\u0646 \u0643\u0644\u0627 \u0627\u0644\u062c\u0646\u0633\u064a\u0646 \u0648\u0645\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0639\u0645\u0627\u0631\u060c \u0645\u0634\u062e\u0651\u0635\u064a\u0646 \u0628\u0623\u062d\u062f \u0627\u0633\u062a\u0637\u0628\u0627\u0628\u0627\u062a \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0648\u0641\u0642 \u0627\u0644\u062f\u0644\u064a\u0644 \u0627\u0644\u062a\u0634\u062e\u064a\u0635\u064a \u0648\u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a \u0644\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0639\u0642\u0644\u064a\u0629 \u2013 \u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0627\u0644\u062e\u0627\u0645\u0633 The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) \u0648\u064a\u062a\u0644\u0642\u0648\u0646 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0639\u0644\u0627\u062c\u0627\u064b \u0645\u0641\u0631\u062f\u0627\u064b \u0644\u0645\u062f\u0629 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631. \u0627\u064f\u0633\u062a\u0628\u0639\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u0639\u0627\u0644\u062c\u0648\u0646 \u0628\u0645\u0636\u0627\u062f\u0627\u062a \u0630\u0647\u0627\u0646 \u0623\u062e\u0631\u0649\u060c \u0648\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0623\u0648 \u0627\u0644\u0645\u0631\u0636\u0639\u0627\u062a\u060c \u0648\u0645\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0623\u0645\u0631\u0627\u0636 \u0643\u0628\u062f\u064a\u0629 \u0623\u0648 \u0643\u0644\u0648\u064a\u0629 \u0645\u0631\u0627\u0641\u0642\u0629\u060c \u0648\u0627\u0644\u0645\u0639\u0627\u0644\u062c\u064a\u0646 \u0628\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0644\u0641\u062a\u0631\u0629 \u062a\u0642\u0644 \u0639\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0633\u062a\u0628\u0627\u0646\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0635\u064f\u0645\u0645\u062a \u0627\u0644\u0627\u0633\u062a\u0628\u0627\u0646\u0629 \u0644\u062c\u0645\u0639 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\u0627\u0644\u062a\u0627\u0631\u064a\u062e \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u060c \u0648\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u062a\u062f\u0627\u0648\u064a \u0628\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0645\u0646 \u062d\u064a\u062b \u062a\u0627\u0631\u064a\u062e \u0627\u0644\u0628\u062f\u0621 \u0648\u0627\u0644\u0627\u0633\u062a\u0637\u0628\u0627\u0628 \u0648\u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u0623\u0645\u062f \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0648\u0645\u0637\u0627\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629<\/strong><strong>Simpson-Angus Scale (SAS)<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u064f\u0636\u0639 \u0647\u0630\u0627 \u0627\u0644\u0645\u0642\u064a\u0627\u0633 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0646 Simpson \u0648Angus \u0639\u0627\u0645 1970 \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0633\u0628\u0628\u0647\u0627 \u062d\u062c\u0628 \u0627\u0644\u062f\u0648\u0628\u0627\u0645\u064a\u0646 \u0644\u062f\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0630\u0647\u0627\u0646\u060c \u0645\u0646 \u062e\u0644\u0627\u0644 \u0625\u062c\u0631\u0627\u0621\u0627\u062a \u064a\u0642\u0648\u0645 \u0628\u0647\u0627 \u0627\u0644\u0641\u0627\u062d\u0635 \u0648\u064a\u064f\u0637\u0644\u0628 \u0645\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0647\u0627 \u0644\u062a\u0642\u064a\u064a\u0645 \u0635\u0644\u0627\u0628\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0627\u0644\u0645\u0646\u0639\u0643\u0633\u0627\u062a \u0648\u0627\u0644\u0631\u0639\u0627\u0634 \u0648\u0627\u0644\u0625\u0644\u0639\u0627\u0628\u060c \u0648\u0625\u062f\u0631\u0627\u062c \u0634\u062f\u062a\u0647\u0627 \u0628\u0645\u0642\u064a\u0627\u0633 \u0645\u062a\u062f\u0631\u062c \u0645\u0646 \u0627\u0644\u0642\u064a\u0645\u0629 (0) \u0627\u0644\u062a\u064a \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u063a\u064a\u0627\u0628 \u0627\u0644\u0639\u0631\u0636 \u0648\u0635\u0648\u0644\u0627\u064b \u0625\u0644\u0649 \u0627\u0644\u0642\u064a\u0645\u0629 (4) \u0648\u0627\u0644\u062a\u064a \u062a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0627\u0644\u0639\u0631\u0636 \u0628\u062d\u062f\u0647 \u0627\u0644\u0623\u0639\u0644\u0649. \u0648\u064a\u0645\u0643\u0646 \u062d\u0633\u0627\u0628 \u0627\u0644\u062d\u0631\u0632 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062c\u0645\u0639 \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u062a\u064a \u064a\u0633\u062c\u0644\u0647\u0627 \u0627\u0644\u0641\u0627\u062d\u0635 \u0644\u0643\u0644 \u0639\u0631\u0636 \u0645\u0646 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629 \u0648\u062a\u0642\u0633\u064a\u0645 \u0627\u0644\u0645\u062c\u0645\u0648\u0639 \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u062f 10\u060c \u0648\u064a\u0634\u064a\u0631 \u0623\u064a\u0651 \u0646\u0627\u062a\u062c \u0623\u0642\u0644 \u0645\u0646 0.3 \u0625\u0644\u0649 \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0637\u0628\u064a\u0639\u064a.(18)<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629<\/strong><strong>Udvalg for Kliniske Undersogelser Side Effect Rating Scale :(UKU)<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0637\u064f\u0648\u0651\u0631 \u0647\u0630\u0627 \u0627\u0644\u0645\u0642\u064a\u0627\u0633 \u0639\u0627\u0645 1987 \u0644\u062a\u0642\u064a\u064a\u0645 \u062d\u062f\u0648\u062b \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062c\u0627\u0646\u0628\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0630\u0647\u0627\u0646 \u0648\u0644\u0627 \u064a\u062a\u062e\u0635\u0635 \u0628\u0646\u0648\u0639\u064d \u0645\u0639\u064a\u0646 \u0645\u0646\u0647\u0627\u060c \u064a\u064f\u0639\u062f \u0645\u0646 \u0623\u0643\u062b\u0631 \u0627\u0644\u0645\u0642\u0627\u064a\u064a\u0633 \u0634\u064a\u0648\u0639\u0627\u064b \u0648\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0627\u064b \u0641\u064a \u0627\u0644\u0623\u0628\u062d\u0627\u062b\u060c \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u062a\u0645 \u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0637\u0628\u064a\u0628 \u0623\u0648 \u0627\u0644\u0645\u0631\u064a\u0636. \u064a\u064f\u0642\u0633\u0645 \u0647\u0630\u0627 \u0627\u0644\u0645\u0642\u064a\u0627\u0633 \u0625\u0644\u0649 \u0623\u0631\u0628\u0639\u0629 \u0623\u0642\u0633\u0627\u0645: \u0639\u0634\u0631\u0629 \u0628\u0646\u0648\u062f \u0644\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0646\u0641\u0633\u064a\u0651\u0629\u060c \u0648\u062b\u0645\u0627\u0646\u064a\u0629 \u0628\u0646\u0648\u062f \u0644\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0635\u0628\u064a\u0651\u0629\u060c \u0648\u0623\u062d\u062f \u0639\u0634\u0631 \u0628\u0646\u062f\u0627\u064b \u0644\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0639\u0635\u0628\u064a\u0651\u0629 \u0627\u0644\u0630\u0627\u062a\u064a\u0651\u0629\u060c \u0648\u062a\u0633\u0639\u0629 \u0639\u0634\u0631 \u0628\u0646\u062f\u0627\u064b \u0644\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649. \u062a\u064f\u0642\u064a\u0651\u0645 \u0634\u062f\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0628\u0631\u0642\u0645 \u064a\u062a\u0631\u0627\u0648\u062d \u0645\u0646 0 (\u063a\u064a\u0627\u0628 \u0627\u0644\u062a\u0623\u062b\u064a\u0631) \u0625\u0644\u0649 3 (\u062a\u0623\u062b\u064a\u0631 \u0634\u062f\u064a\u062f). (19) (20)<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062a\u0651\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u062f\u0651\u0648\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u0645\u064f\u062d\u062a\u0645\u0644\u0629<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0646\u0627\u0648\u0644\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0645\u064f\u062d\u062a\u0645\u0644 \u062a\u0622\u062b\u0631\u0647\u0627 \u0645\u0639 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0628\u0627\u0644\u0627\u0633\u062a\u0646\u0627\u062f \u0625\u0644\u0649 \u062c\u0645\u0644\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u062c\u0639\u064a\u0651\u0627\u062a \u0646\u0630\u0643\u0631 \u0645\u0646\u0647\u0627 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA)\u060c \u0648\u062c\u062f\u0648\u0644 \u0641\u0644\u0648\u0643\u0647\u0627\u0631\u062a Flockhart \u0644\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629\u060c \u0648\u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0631\u0642\u0645 85 \u0645\u0646 \u0645\u0631\u062c\u0639 \u0627\u0644\u0648\u0635\u0641\u0627\u062a \u0627\u0644\u0648\u0637\u0646\u064a \u0627\u0644\u0628\u0631\u064a\u0637\u0627\u0646\u064a .(BNF) British National Formulary<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u0651\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u064f\u0633\u062a\u062e\u062f\u0645\u062a \u0628\u0631\u0645\u062c\u064a\u0629 \u00ae GraphPad Prism \u0628\u0625\u0635\u062f\u0627\u0631\u0647\u0627 \u0627\u0644\u062a\u0627\u0633\u0639 \u0648\u0628\u0631\u0645\u062c\u064a\u0629 SPSS \u0628\u0625\u0635\u062f\u0627\u0631\u0647\u0627 \u0627\ufedf 26 \u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b. \u0627\u064f\u062c\u0631\u064a \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0648\u0635\u0641\u064a \u0648\u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0641\u0626\u0648\u064a\u0629 \u0648\u0627\u0644\u0627\u0633\u0645\u064a\u0629 \u0628\u0627\u0644\u062a\u0648\u0627\u062a\u0631 \u0648\u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0643\u0645\u064a\u0651\u0629 \u0628\u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u0648\u0627\u0644\u0648\u0633\u064a\u0637 \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a\u0651. \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u062e\u062a\u0628\u0627\u0631Fisher&#8217;s exact \u00a0\u0644\u0644\u0639\u064a\u0646\u062a\u064a\u0646 \u063a\u064a\u0631 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u062a\u064a\u0646 \u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0648\u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0627\u064f\u0639\u062a\u0645\u062f\u062a \u0642\u064a\u0645\u0629 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 0.05&gt;p \u0643\u0642\u064a\u0645\u0629 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0641\u064a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0637\u0628\u0651\u0642\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u0651\u062a\u0627\u0626\u062c\u00a0<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u0651\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0651\u0629 \u0648\u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0646 \u0623\u0635\u0644 563 \u0645\u0631\u0636\u0649 \u0646\u0641\u0633\u064a\u064a\u0646 \u0645\u064f\u0639\u0627\u0644\u062c\u064a\u0646 \u0628\u0645\u0636\u0627\u062f\u0627\u062a \u0630\u0647\u0627\u0646 \u062c\u0631\u0649 \u062a\u0642\u064a\u064a\u0645 \u0623\u0647\u0644\u064a\u062a\u0647\u0645 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u062d\u0642\u0651\u0642 51 \u0641\u0631\u062f\u0627\u064b \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 (\u0645\u064f\u0639\u0627\u0644\u062c\u064a\u0646 \u0628\u0627\u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0639\u0644\u0627\u062c\u0627\u064b \u0645\u0641\u0631\u062f\u0627\u064b \u0645\u0636\u0627\u062f\u0627\u064b \u0644\u0644\u0630\u0647\u0627\u0646) \u0648\u0627\u0641\u0642\u0648\u0627 \u0639\u0644\u0649 \u0627\u0644\u0645\u064f\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629. \u062a\u0648\u0632\u0639\u0648\u0627 \u0628\u064a\u0646 34 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0646 \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0645\u0648\u0627\u0633\u0627\u0629 \u0627\u0644\u062c\u0627\u0645\u0639\u064a\u060c \u0648\u062b\u0645\u0627\u0646\u064a\u0629 \u0645\u0631\u0636\u0649 \u0645\u0646 \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0628\u0646 \u0631\u0634\u062f \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0646\u0641\u0633\u064a\u0629\u060c \u0648\u062a\u0633\u0639\u0629 \u0645\u0631\u0636\u0649 \u0645\u0646 \u0639\u064a\u0627\u062f\u0627\u062a \u0646\u0641\u0633\u064a\u0651\u0629 \u062e\u0627\u0635\u0629. \u064a\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 (1) \u0645\u062e\u0637\u0637\u0627\u064b \u0627\u0646\u0633\u064a\u0627\u0628\u064a\u0651\u0627\u064b \u062a\u0641\u0635\u064a\u0644\u064a\u0627\u064b \u0644\u0645\u062c\u0631\u064a\u0627\u062a \u0627\u0646\u062a\u0642\u0627\u0621 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0643\u0627\u0646 \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0646 \u0645\u062d\u0627\u0641\u0638\u062a\u064a \u062f\u0645\u0634\u0642 (41.2%) \u0648\u0631\u064a\u0641\u0647\u0627 (25.5%). \u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0639\u0645\u0627\u0631 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u064a\u0646 15-58 \u0639\u0627\u0645\u0627\u064b \u0628\u0645\u062a\u0648\u0633\u0637 \u062d\u0633\u0627\u0628\u064a\u0651 \u0642\u062f\u0631\u0647 31.35 \u0639\u0627\u0645\u0627\u064b \u0648\u0627\u0646\u062d\u0631\u0627\u0641\u064d \u0645\u0639\u064a\u0627\u0631\u064a\u0651 \u0628\u0644\u063a 12.94 \u0639\u0627\u0645\u0627\u064b. \u0648\u0643\u0627\u0646\u062a \u063a\u0627\u0644\u0628\u064a\u0629 \u0627\u0644\u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0628\u0646\u0633\u0628\u0629 (70.6%)\u060c \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0639\u0644\u0649 \u0628\u0645\u0633\u062a\u0648\u0649 \u062a\u0639\u0644\u064a\u0645\u064a\u0651 \u062c\u0627\u0645\u0639\u064a\u0651 (33.3%)\u060c \u0648\u062a\u0642\u0627\u0631\u0628\u062a \u0646\u0633\u0628\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646 (56.9%) \u0645\u0639 \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646. \u062a\u062c\u0627\u0648\u0632 \u0639\u062f\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u0634\u062e\u0635\u064a\u0646 \u0628\u0627\u0644\u0641\u0635\u0627\u0645 \u0646\u0635\u0641 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 (58.8%)\u060c \u062a\u0644\u0627\u0647 \u0627\u0636\u0637\u0631\u0627\u0628 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0642\u0637\u0628 (21.6%) \u0641\u064a \u062d\u064a\u0646 \u062a\u0648\u0632\u0639 \u0628\u0627\u0642\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0646\u0641\u0633\u064a\u0651\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 (19.6%)\u060c \u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u062c\u0631\u0639\u0629 \u0627\u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0643\u0645\u0636\u0627\u062f \u0630\u0647\u0627\u0646 \u0645\u0641\u0631\u062f 4 \u0645\u063a\/\u064a\u0648\u0645. \u062a\u0646\u0627\u0648\u0644 \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 \u062b\u0644\u062b \u0627\u0644\u0645\u0631\u0636\u0649 (37.3%) \u0623\u062f\u0648\u064a\u0629 \u0644\u0627\u0633\u062a\u0637\u0628\u0627\u0628\u0627\u062a \u0623\u062e\u0631\u0649 \u0648\u0645\u062d\u062a\u0645\u0644\u0629 \u0627\u0644\u062a\u0622\u062b\u0631 \u0627\u0644\u062f\u0651\u0648\u0627\u0626\u064a \u0645\u0639 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628. \u0623\u0641\u0627\u062f 41.2% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0648\u062c\u0648\u062f \u0642\u0635\u0629 \u0639\u0627\u0626\u0644\u064a\u0651\u0629 \u0644\u0645\u0631\u0636 \u0646\u0641\u0633\u064a\u060c \u0643\u0645\u0627 \u0648\u064f\u0635\u0641 \u0645\u0636\u0627\u062f \u0643\u0648\u0644\u064a\u0646\u064a \ufedf 33.3% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u062a\u062f\u0628\u064a\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629. \u0648\u0647\u0630\u0627 \u0645\u0627 \u064a\u064f\u0648\u0636\u0651\u062d\u0647 \u0627\u0644\u062c\u062f\u0648\u0644\u0627\u0646 (1) \u0648(2).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1865 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/25-300x241.png\" alt=\"\" width=\"505\" height=\"405\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/25-300x241.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/25.png 505w\" sizes=\"auto, (max-width: 505px) 100vw, 505px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 1. \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n<table class=\" aligncenter\" style=\"height: 884px; width: 50.0428%;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062e\u0635\u0627\u0626\u0635 <\/strong><\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 60.7273%; text-align: center; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u0646\u0633<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0625\u0646\u0627\u062b<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">15 (29.4)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0630\u0643\u0648\u0631<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">36 (70.6)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 60.7273%; text-align: center; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0639\u0645\u0631 (\u0639\u0627\u0645)<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">&lt;20<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">8 (15.7)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">[20-29]<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">24 (47.1)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">[30-39]<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">4 (7.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">[40-49]<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">8 (15.7)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">[50-59]<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">7 (13.7)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 60.7273%; text-align: center; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u0645\u0634\u0642<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">21 (41.2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0631\u064a\u0641 \u062f\u0645\u0634\u0642<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">13 (25.5)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u0644\u0628<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">4 (7.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0644\u0627\u0630\u0642\u064a\u0629<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">3 (5.9)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0627\u0642\u064a \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0627\u062a \u0627\u0644\u0633\u0648\u0631\u064a\u0651\u0629<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">10 (19.6)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 60.7273%; text-align: center; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062a\u0639\u0644\u064a\u0645\u064a<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u062d\u0648 \u0623\u0645\u064a\u0629\/\u0623\u0645\u064a<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">2 (3.9)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0628\u062a\u062f\u0627\u0626\u064a<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">14 (27.5)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0639\u062f\u0627\u062f\u064a<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">9 (17.6)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u062b\u0627\u0646\u0648\u064a<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">9 (17.6)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0627\u0645\u0639\u064a<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">17 (33.3)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 60.7273%; text-align: center; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u062f\u062e\u064a\u0646<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0639\u0645<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">22 (43.1)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 51px;\">\n<td style=\"width: 26.5608%; text-align: center; height: 51px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0627<\/span><\/td>\n<td style=\"width: 34.1665%; text-align: center; height: 51px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">29 (56.9)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong style=\"font-family: 'times new roman', times, serif; text-align: justify;\">\u00a0 \u00a0\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u00a0\u0627\u0644\u062c\u062f\u0648\u0644 2. \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n<table class=\" aligncenter\" style=\"width: 37.7739%; height: 1340px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062e\u0635\u0627\u0626\u0635 <\/strong><\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 40px;\">\n<td style=\"width: 160.761%; height: 40px;\" colspan=\"2\" width=\"272\">\n<p style=\"text-align: center;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u0634\u062e\u064a\u0635<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 29px;\">\n<td style=\"width: 61.3782%; height: 29px;\" width=\"182\">\n<p style=\"text-align: right;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u0635\u0627\u0645<\/span><\/p>\n<\/td>\n<td style=\"width: 99.3831%; height: 29px;\" width=\"91\">\n<p style=\"text-align: right;\"><span style=\"font-family: 'times new roman', times, serif;\">30 (58.8)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0642\u0637\u0628<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">11 (21.6)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0643\u062a\u0626\u0627\u0628<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">3 (5.9)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0645\u0633\u0644\u0643<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">1 (2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0637\u064a\u0641 \u0627\u0644\u062a\u0648\u062d\u062f<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">1 (2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0630\u0647\u0646\u064a<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">1 (2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0630\u0647\u0627\u0646\u064a\u0629 \u0623\u062e\u0631\u0649:<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">4 (7.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0636\u0637\u0631\u0627\u0628 \u062a\u0648\u0647\u0645\u064a<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">1 (2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0636\u0637\u0631\u0627\u0628 \u0630\u0647\u0627\u0646\u064a \u0648\u062c\u064a\u0632<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">2 (3.9)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0636\u0637\u0631\u0627\u0628 \u0641\u0635\u0627\u0645\u064a \u0627\u0644\u0634\u0643\u0644<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">1 (2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 160.761%; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062c\u0631\u0639\u0629 \u0627\u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 (\u0645\u063a\/\u064a\u0648\u0645)<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">2<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">5 (9.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">4<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">24 (41.1)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">6<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">12 (23.5)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">8<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">9 (17.6)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">12<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">1 (2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 160.761%; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0651\u0629<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0627 \u064a\u0648\u062c\u062f<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">32 (62.7)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0639\u0645 \u064a\u0648\u062c\u062f<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">19 (37.3)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u062b\u0628\u0637\u0627\u062a CYP2D6 \u0642\u0648\u064a\u0651\u0629<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">6 (11.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u062b\u0628\u0637\u0627\u062a CYP2D6 \u0645\u062a\u0648\u0633\u0637\u0629<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">6 (11.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u062b\u0628\u0637\u0627\u062a CYP2D6 \u0636\u0639\u064a\u0641\u0629<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">3 (5.9)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u062d\u0631\u0651\u0636\u0627\u062a CYP3A4 \u0642\u0648\u064a\u0651\u0629<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">4 (7.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 160.761%; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u0646\u0638\u0648\u0645\u0629 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0651\u0629<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0645\u0648\u0627\u0633\u0627\u0629 \u0627\u0644\u062c\u0627\u0645\u0639\u064a<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">34 (66.7)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u064a\u0627\u062f\u0627\u062a \u062e\u0627\u0635\u0651\u0629<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">9 (17.6)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0628\u0646 \u0631\u0634\u062f \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0646\u0641\u0633\u064a\u0651\u0629<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">8 (15.7)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 160.761%; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0642\u0635\u0629 \u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0645\u0631\u0636 \u0646\u0641\u0633\u064a<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0639\u0645<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">21 (41.2)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0627<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"91\"><span style=\"font-family: 'times new roman', times, serif;\">30 (58.8)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 160.761%; height: 24px;\" colspan=\"2\" width=\"272\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0625\u062f\u062e\u0627\u0644 \u0645\u0636\u0627\u062f \u0643\u0648\u0644\u064a\u0646\u064a\u0651<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 24px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0639\u0645<\/span><\/td>\n<td style=\"width: 99.3831%; height: 24px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">\u00a0(33.3%) 17<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 61.3782%; height: 57px;\" width=\"182\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0627<\/span><\/td>\n<td style=\"width: 99.3831%; height: 57px;\" width=\"90\"><span style=\"font-family: 'times new roman', times, serif;\">\u00a0(66.7%) 34<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong style=\"font-family: 'times new roman', times, serif; text-align: justify;\">\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0648\u0645\u0627\u0647\u064a\u062a\u0647\u0627<\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0627\u0646\u0649 \u0623\u0643\u062b\u0631 \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0631\u0628\u0627\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 (n=41\u060c 80.4%) \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646\u060c \u0648\u0643\u0627\u0646\u062a \u0627\u0644\u0633\u0628\u0628 \u0641\u064a \u0625\u064a\u0642\u0627\u0641 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0644\u062f\u0649 \u0623\u0631\u0628\u0639\u0629 \u0645\u0631\u0636\u0649 (7.8%) \u0628\u0633\u0628\u0628 \u0639\u062f\u0645 \u062a\u062d\u0645\u0651\u0644\u0647\u0627. \u0644\u064f\u0648\u062d\u0638 \u0623\u0646\u0651 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629 \u0647\u064a \u0627\u0644\u0623\u0643\u062b\u0631 \u062a\u0648\u0627\u062a\u0631\u0627\u064b (n=30\u060c 58.8%) \u062a\u0646\u0648\u0651\u0639\u062a \u0628\u064a\u0646 \u0639\u0633\u0631 \u0627\u0644\u0645\u0642\u0648\u064a\u0629 (n=10\u060c 19.6%) \u0648\u0627\u0644\u0631\u0639\u0627\u0634 (n=6\u060c 11.8%) \u0648\u0627\u0644\u0635\u0644\u0627\u0628\u0629 (n=8\u060c 15.7%) \u0648\u062a\u0628\u0627\u0637\u0624 \u0627\u0644\u062d\u0631\u0643\u0629 (n=3\u060c 5.9%) \u0648\u0627\u0644\u062a\u0645\u0644\u0645\u0644 (n=3\u060c 5.9%). \u064a\u064f\u0636\u0627\u0641 \u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0643\u0644\u064c \u0645\u0646 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0648\u0632\u0646 (n=12\u060c 23.5%) \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0644\u0639\u0627\u0628 (n=9\u060c 17.6%)\u060c \u0648\u0627\u0644\u0634\u0639\u0648\u0631 \u0628\u0627\u0644\u062a\u0639\u0628 (n=7\u060c 13.7%)\u060c \u0648\u0627\u0644\u0635\u062f\u0627\u0639 (n=6\u060c 11.8%). \u0639\u0627\u0646\u0649 \u0633\u062a\u0629 \u0645\u0631\u0636\u0649 \u0645\u0646 \u0623\u0635\u0644 36 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0627\u0644\u0630\u0643\u0648\u0631 \u0645\u0646 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0641\u064a \u0627\u0644\u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u062c\u0646\u0633\u064a\u0629 (n=6\u060c 16.7%)\u060c \u0634\u0645\u0644\u062a \u0643\u0644\u0627\u064b \u0645\u0646 \u062e\u0644\u0644 \u0641\u064a \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0628 (n=2\u060c 5.6%) \u0648\u062e\u0644\u0644 \u0641\u064a \u0627\u0644\u0642\u0630\u0641 (n=2\u060c 5.6%)\u060c \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0646\u0634\u0648\u0629 (n=1\u060c 2.8%) \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0631\u063a\u0628\u0629 \u0627\u0644\u062c\u0646\u0633\u064a\u0629 (n=1\u060c 2.8%)\u060c \u0648\u0643\u0645\u0627 \u0639\u0627\u0646\u062a \u0623\u0631\u0628\u0639 \u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646 \u0623\u0635\u0644 15 \u0645\u0631\u064a\u0636\u0629 \u0645\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u0637\u0645\u062b (n=4\u060c 26.7%). \u062a\u0646\u0648\u0651\u0639\u062a \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0628\u064a\u0646 \u0627\u0644\u0635\u0651\u0639\u0648\u0628\u0629 \u0641\u064a \u0627\u0644\u062a\u0631\u0643\u064a\u0632 (n=6\u060c 11.8%)\u060c \u0648\u062f\u0648\u0627\u0631 \u0646\u0627\u062c\u0645 \u0639\u0646 \u0647\u0628\u0648\u0637 \u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0628\u064a (n=5\u060c 9.8%)\u060c \u0648\u0627\u0644\u062a\u0648\u062a\u0631 (n=4\u060c 7.8%)\u060c \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0623\u062d\u0644\u0627\u0645 (n=4\u060c 7.8%)\u060c \u0648\u0634\u0639\u0648\u0631 \u0628\u0627\u0644\u062c\u0641\u0627\u0641 \u0623\u0648 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0644\u0639\u0627\u0628 (n=3\u060c 5.9%)\u060c \u0648\u0627\u0644\u062a\u0631\u0643\u064a\u0646 \u0623\u0648 \u0627\u0644\u062a\u0647\u062f\u0626\u0629 (n=3\u060c 5.9%)\u060c \u0648\u062b\u0631 \u0627\u0644\u062d\u0644\u064a\u0628 (n=2\u060c 3.9%)\u060c \u0648\u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0633\u0627\u0639\u0627\u062a \u0627\u0644\u0646\u0648\u0645 (n=2\u060c 3.9%)\u060c \u0648\u0636\u0639\u0641 \u0627\u0644\u0630\u0627\u0643\u0631\u0629 (n=2\u060c 3.9%)\u060c \u0648\u0646\u0642\u0635 \u0627\u0644\u062a\u0639\u0627\u0637\u0641 (n=2\u060c 3.9%)\u060c \u0648\u0646\u0642\u0635\u0627\u0646 \u0627\u0644\u0648\u0632\u0646 (n=1\u060c 2%)\u060c\u00a0 \u0648\u0634\u0639\u0648\u0631 \u0627\u0644\u0627\u0643\u062a\u0626\u0627\u0628 (n=1\u060c 2%)\u060c \u0648\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u0637\u0627\u0628\u0642\u0629 (n=1\u060c 2%)\u060c \u0648\u0627\u0644\u0627\u0645\u0633\u0627\u0643 (n=1\u060c 2%)\u060c\u00a0 \u0648\u0627\u0644\u0628\u0648\u0627\u0644 (n=1\u060c 2%)\u060c \u0648\u062a\u0633\u0631\u0639 \u0627\u0644\u0642\u0644\u0628 (n=1\u060c 2%). \u062a\u0646\u0648\u0639\u062a \u0634\u062f\u0651\u062a\u0647\u0627 \u0628\u064a\u0646 \u0627\u0644\u062e\u0641\u064a\u0641\u0629 \u0648\u0627\u0644\u0645\u062a\u0648\u0633\u0637\u0629 \u0648\u0627\u0644\u0634\u062f\u064a\u062f\u0629. \u0648\u0647\u0630\u0627 \u0645\u0627 \u064a\u064f\u0648\u0636\u062d\u0647 \u0627\u0644\u0634\u0643\u0644 (2).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u0651\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0651\u0629 \u0645\u0639 \u0627\u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0628\u064a\u0651\u0646 \u0623\u0646 19 \u0645\u0631\u064a\u0636\u0627\u064b (37.3%) \u0643\u0627\u0646\u0648\u0627 \u064a\u0633\u062a\u062e\u062f\u0645\u0648\u0646 \u062f\u0648\u0627\u0621\u064b \u0648\u0627\u062d\u062f\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0628\u0627\u0644\u062a\u0632\u0627\u0645\u0646 \u0645\u0639 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0648\u064a\u062d\u062a\u0645\u0644 \u0644\u0625\u062d\u062f\u0627\u062b\u0647 \u062a\u0622\u062b\u0631\u0627\u062a \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u062d\u0631\u0643\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062e\u0635\u0648\u0635 \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646\u060c \u0645\u0639 \u062a\u0623\u0643\u064a\u062f \u062d\u062f\u0648\u062b \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0636\u0627\u0626\u0631\u0629 \u062e\u0627\u0635\u0629 \u0628\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0645\u062b\u0644 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629 \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0648\u0632\u0646 \u0644\u062f\u0649 18 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0646\u0647\u0645. \u062a\u0646\u0648\u0639\u062a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0628\u064a\u0646 \u0645\u062b\u0628\u0637 \u0642\u0648\u064a \u0644\u062f\u0649 (n=6\u060c 11.8%) \u0645\u062b\u0644 \u0641\u0644\u0648\u0643\u0633\u062a\u064a\u0646 Fluoxetine\u060c \u0648\u0645\u062b\u0628\u0637 \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0644\u062f\u0649 (n=6\u060c 11.8%) \u0645\u062b\u0644 \u0633\u064a\u0631\u062a\u0631\u0627\u0644\u064a\u0646 Sertraline\u060c \u0648\u0645\u062b\u0628\u0637 \u0636\u0639\u064a\u0641 \u0644\u062f\u0649 (n=3\u060c 5.9%) \u0645\u062b\u0644 \u0625\u0633\u064a\u062a\u0627\u0644\u0648\u0628\u0631\u0627\u0645 Esitalopram \u0648\u062c\u0645\u064a\u0639\u0647\u0627 \u0645\u0646 \u0632\u0645\u0631\u0629 SSRIs\u060c \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u0627\u0642\u062a\u0635\u0631 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u062d\u0631\u0636\u0627\u062a \u0625\u0646\u0632\u064a\u0645 CYP3A4 \u0639\u0644\u0649 \u0623\u0631\u0628\u0639\u0629 \u0645\u0631\u0636\u0649 (7.8%)\u060c \u0648\u0635\u064f\u0646\u0651\u0641\u062a \u062c\u0645\u064a\u0639\u0647\u0627 \u0639\u0644\u0649 \u0623\u0646\u0651\u0647\u0627 \u0645\u062d\u0631\u0636\u0627\u062a \u0642\u0648\u064a\u0651\u0629 \u0645\u062b\u0644 \u0643\u0627\u0631\u0628\u0627\u0645\u0627\u0632\u064a\u0628\u064a\u0646 Carbamazepine \u0645\u0646 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u062c (anticonvulsant)\u060c \u0648\u0647\u0630\u0627 \u0645\u064f\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u0634\u0643\u0644 (3).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1866 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/26-300x245.png\" alt=\"\" width=\"505\" height=\"412\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/26-300x245.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/26.png 616w\" sizes=\"auto, (max-width: 505px) 100vw, 505px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1867 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/27-300x174.png\" alt=\"\" width=\"464\" height=\"269\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/27-300x174.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2024\/09\/27.png 655w\" sizes=\"auto, (max-width: 464px) 100vw, 464px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0645\u0639 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0644\u0645\u0631\u0636\u0649<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0648\u0644 (3) \u062a\u0648\u0632\u0639 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0648\u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0651\u0629. \u0643\u0645\u0627 \u064a\u064f\u0648\u0636\u062d \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u0623\u064f\u062c\u0631\u064a\u062a \u0641\u064a \u0645\u062d\u0627\u0648\u0644\u062a\u0646\u0627 \u0644\u062a\u062d\u0631\u064a \u0639\u0644\u0627\u0642\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0647\u0630\u0647 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0648\u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629. \u062a\u0634\u064a\u0631 \u0642\u064a\u0645 \u0627\u0644\u062f\u0651\u0644\u0627\u0644\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 P \u0627\u0644\u062a\u064a \u062a\u062c\u0627\u0648\u0632\u062a (0.05) \u0625\u0644\u0649 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0648\u0645\u0639\u0627\u0644\u0645 \u0634\u0645\u0644\u062a \u0643\u0644\u0627\u064b \u0645\u0646 \u062c\u0646\u0633 \u0627\u0644\u0645\u0631\u064a\u0636 \u0648\u0627\u0644\u0639\u0645\u0631 \u0648\u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629 \u0648\u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0648\u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0648\u0635\u0648\u0641\u0629 \u0645\u0646 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0648\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062d\u0631\u0636\u0627\u062a CYP3A4. \u0627\u0632\u062f\u0627\u062f \u062e\u0637\u0631 \u0638\u0647\u0648\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0644\u062f\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062b\u0628\u0637\u0627\u062a CYP2D6 \u0628\u0646\u062d\u0648 \u0623\u0631\u0628\u0639\u0629 \u0623\u0636\u0639\u0627\u0641 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u063a\u064a\u0627\u0628\u0647\u0627 (OR=4.667) \u0648\u0628\u0641\u0648\u0627\u0635\u0644 \u0645\u0648\u062b\u0648\u0642\u064a\u0651\u0629 \u063a\u064a\u0631 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (95%CI: 0.7310-54.46, P=0.2460).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644<\/strong><strong>3 <\/strong><strong>. \u062a\u0648\u0627\u062a\u0631\u0627\u062a \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0651\u0627\u0626\u0631\u0629 \u0644\u0644\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0648\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629<\/strong><\/span><\/p>\n<table class=\" aligncenter\" style=\"height: 700px; width: 69.1176%;\" width=\"76.6632%\">\n<tbody>\n<tr style=\"height: 120px;\">\n<td style=\"width: 37.8737%; height: 120px;\" colspan=\"2\" width=\"230\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062e\u0635\u0627\u0626\u0635<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 120px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0648\u062c\u0648\u062f \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>(<\/strong><strong>n=41<\/strong><strong>)<\/strong><\/span><\/td>\n<td style=\"width: 22.093%; height: 120px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u063a\u064a\u0627\u0628 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>(<\/strong><strong>n=10<\/strong><strong>)<\/strong><\/span><\/td>\n<td style=\"width: 18.7548%; height: 120px;\" width=\"83\"><span style=\"font-family: 'times new roman', times, serif;\"><strong><em>P-<\/em><\/strong><strong>value<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 102.476%; height: 24px;\" colspan=\"5\" width=\"601\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 25px;\">\n<td style=\"width: 18.7564%; height: 50px;\" rowspan=\"2\" width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u0646\u0633<\/strong><\/span><\/td>\n<td style=\"width: 19.1173%; height: 25px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0630\u0643\u0631<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 25px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">28 (77.8%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 25px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">8 (22.2%)<\/span><\/td>\n<td style=\"width: 18.7548%; height: 50px;\" rowspan=\"2\" width=\"83\">\n<p style=\"text-align: center;\"><span style=\"font-family: 'times new roman', times, serif;\">0.7027<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 25px;\">\n<td style=\"width: 19.1173%; height: 25px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0623\u0646\u062b\u0649<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 25px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">13 (86.7%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 25px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">2 (13.3%)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 18.7564%; height: 96px;\" rowspan=\"2\" width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629<\/strong><\/span><\/td>\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062f\u0645\u0634\u0642 \u0648\u0631\u064a\u0641\u0647\u0627<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">29 (85.3%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">5 (14.7%)<\/span><\/td>\n<td style=\"width: 18.7548%; height: 96px;\" rowspan=\"2\" width=\"83\"><span style=\"font-family: 'times new roman', times, serif;\">0.2700<\/span><\/td>\n<\/tr>\n<tr style=\"height: 72px;\">\n<td style=\"width: 19.1173%; height: 72px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0628\u0627\u0642\u064a \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0627\u062a \u0627\u0644\u0633\u0648\u0631\u064a\u0629<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 72px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">12 (70.6%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 72px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">5 (29.4%)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 18.7564%; height: 48px;\" rowspan=\"2\" width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0639\u0645\u0631<\/strong><\/span><\/td>\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\">[29-15]<\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">24 (75%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">8 (25%)<\/span><\/td>\n<td style=\"width: 18.7548%; height: 48px;\" rowspan=\"2\" width=\"83\"><span style=\"font-family: 'times new roman', times, serif;\">0.2866<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\">[59-30]<\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">17 (89.5%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">2 (10.5%)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 18.7564%; height: 48px;\" rowspan=\"2\" width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u062f\u062e\u064a\u0646<\/strong><\/span><\/td>\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u0639\u0645<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">19 (86.4%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">3 (13.6%)<\/span><\/td>\n<td style=\"width: 18.7548%; height: 48px;\" rowspan=\"2\" width=\"83\"><span style=\"font-family: 'times new roman', times, serif;\">0.4833<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0644\u0627<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">22 (75.9%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">7 (24.1%)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 102.476%; height: 24px;\" colspan=\"5\" width=\"601\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 45px;\">\n<td style=\"width: 18.7564%; height: 90px;\" rowspan=\"2\" width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062c\u0631\u0639\u0629<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif;\"><strong>(<\/strong><strong>\u0645\u063a<\/strong><strong>\/<\/strong><strong>\u0627\u0644\u064a\u0648\u0645<\/strong><strong>)<\/strong><\/span><\/td>\n<td style=\"width: 19.1173%; height: 45px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>2-4<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 45px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">23 (79.3%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 45px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">6 (20.7%)<\/span><\/td>\n<td style=\"width: 18.7548%; height: 90px;\" rowspan=\"2\" width=\"83\"><span style=\"font-family: 'times new roman', times, serif;\">0.9999&lt;<\/span><\/td>\n<\/tr>\n<tr style=\"height: 45px;\">\n<td style=\"width: 19.1173%; height: 45px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>6-12<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 45px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">18 (81.8%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 45px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">4 (18.2%)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 18.7564%; height: 48px;\" rowspan=\"2\" width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u062b\u0628\u0637\u0627\u062a <\/strong><strong>CYP2D6<\/strong><\/span><\/td>\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u0639\u0645<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">14 (93.3%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">1 (6.7%)<\/span><\/td>\n<td style=\"width: 18.7548%; height: 48px;\" rowspan=\"2\" width=\"83\"><span style=\"font-family: 'times new roman', times, serif;\">0.2460<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0644\u0627<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">27 (75%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">9 \u00a0(25%)<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 18.7564%; height: 48px;\" rowspan=\"2\" width=\"85\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u062d\u0631\u0636\u0627\u062a <\/strong><strong>CYP3A4<\/strong><\/span><\/td>\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u0639\u0645<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">4 (100%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">0 (0%)<\/span><\/td>\n<td style=\"width: 18.7548%; height: 48px;\" rowspan=\"2\" width=\"83\"><span style=\"font-family: 'times new roman', times, serif;\">0.5734<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 19.1173%; height: 24px;\" width=\"145\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0644\u0627<\/strong><\/span><\/td>\n<td style=\"width: 23.7542%; height: 24px;\" width=\"150\"><span style=\"font-family: 'times new roman', times, serif;\">37 (78.7%)<\/span><\/td>\n<td style=\"width: 22.093%; height: 24px;\" width=\"138\"><span style=\"font-family: 'times new roman', times, serif;\">10 (21.3%)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0632\u0627\u064a\u062f \u0627\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0639\u0627\u0644\u0645\u064a\u0651\u0627\u064b \u0628\u062e\u0637\u0648\u0631\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0646\u0641\u0633\u064a\u0629 \u0648\u0645\u0627 \u064a\u062a\u0631\u062a\u0628 \u0639\u0644\u064a\u0647\u0627 \u0645\u0646 \u0645\u0634\u0627\u0643\u0644 \u0635\u062d\u064a\u0651\u0629 \u0648\u0623\u0639\u0628\u0627\u0621 \u0627\u0642\u062a\u0635\u0627\u062f\u064a\u0651\u0629. (7) \u0627\u0644\u0623\u0645\u0631 \u0627\u0644\u0630\u064a \u062f\u0641\u0639 \u062f\u0631\u0627\u0633\u0627\u062a \u0639\u062f\u064a\u062f\u0629 \u0625\u0644\u0649 \u0631\u0635\u062f \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0646\u0651\u0641\u0633\u064a\u0651\u0629 \u0633\u0648\u0627\u0621 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0642\u064a\u0645\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0634\u0641\u0649 (7) (21) \u0623\u0648 \u0627\u0644\u0645\u064f\u0631\u0627\u062c\u0639\u064a\u0646 \u0644\u0644\u0639\u064a\u0627\u062f\u0627\u062a \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629. (6) (22) \u062a\u064f\u0639\u062f \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u0646 \u0623\u0648\u0627\u0626\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0641\u064a \u0633\u0648\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0631\u0651\u062a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0627\u0644\u0645\u0631\u0627\u0641\u0642\u0629 \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646\u061b \u062d\u064a\u062b \u0628\u064a\u0651\u0646\u062a \u0627\u0646\u062a\u0634\u0627\u0631\u0627\u064b \u0645\u0631\u062a\u0641\u0639\u0627\u064b \u0644\u0647\u0630\u0647 \u0627\u0644\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0648\u0628\u0646\u0633\u0628\u0629 \u0642\u062f\u0631\u0647\u0627 (80.4%)\u060c \u0645\u0642\u0627\u0631\u0628\u0629\u064b \u0628\u0630\u0644\u0643 \u0646\u0633\u0628\u0629 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0641\u064a \u0627\u0644\u0647\u0646\u062f (68.2%) \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0641\u0635\u0627\u0645 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Alladi \u0648\u0632\u0645\u0644\u0627\u0626\u0647.(23) \u00a0\u0648\u0642\u062f \u0634\u063a\u0644\u062a \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0643\u0628\u0631 \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 (58.8%) \u0648\u0643\u0627\u0646 \u0639\u0633\u0631 \u0627\u0644\u0645\u0642\u0648\u064a\u0629 \u0641\u064a \u0645\u0642\u062f\u0645\u062a\u0647\u0627\u060c \u0648\u062a\u0641\u0627\u0648\u062a\u062a \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649\u061b \u0641\u0642\u062f \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u062a\u0627\u062b\u064a\u0631\u0627\u062a \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u0631\u0645\u064a\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u0634\u0627\u0628\u0647\u0629\u064b \u0644\u0646\u0633\u0628\u062a\u0647\u0627 \u0641\u064a \u0627\u0644\u064a\u0627\u0628\u0627\u0646 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Ito \u0648\u0632\u0645\u0644\u0627\u0626\u0647 (59.1%)\u060c (24) \u0648\u0645\u0631\u062a\u0641\u0639\u0629 \u062c\u062f\u0627\u064b \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u062a\u0648\u0627\u062a\u0631\u0647\u0627 \u0641\u064a \u0631\u0648\u0645\u0627\u0646\u064a\u0627 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Cojocaru \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627 (16.07%) \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0628\u0627\u0644\u063a\u064a\u0646 \u0645\u064f\u0634\u062e\u0635\u064a\u0646 \u0628\u0627\u0644\u0641\u0635\u0627\u0645. (25) \u0627\u062d\u062a\u0644\u062a \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0645\u0631\u062a\u0628\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u062a\u0648\u0627\u062a\u0631 \u0628\u064a\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u064a \u0628\u062d\u062b\u0646\u0627 \u0648\u0628\u0646\u0633\u0628\u0629 \u0642\u0627\u0631\u0628\u062a \u0631\u0628\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 (23.5%)\u060c \u0648\u0643\u0627\u0646 \u0647\u0630\u0627 \u0627\u0644\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0630\u064a \u0633\u062c\u0644\u062a\u0647 \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0623\u0639\u0644\u0649 \u0628\u0642\u0644\u064a\u0644 \u0645\u0646 \u062a\u0648\u0627\u062a\u0631 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0645\u064f\u0633\u062c\u0644 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Cojocaru \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627 (8.92%(. (25) \u0648\u0643\u0627\u0646 \u0623\u062e\u0641\u0636 \u0628\u0642\u0644\u064a\u0644 \u0645\u0646 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u062a\u064a \u0648\u0631\u062f\u062a \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Almoguera \u0648\u0632\u0645\u0644\u0627\u0626\u0647 (36%) \u0641\u064a \u0627\u0633\u0628\u0627\u0646\u064a\u0627. (26) \u064a\u0645\u0643\u0646 \u062a\u0641\u0633\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u062a\u0641\u0627\u0648\u062a\u0627\u062a \u0641\u064a \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0628\u064a\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0628\u0627\u062e\u062a\u0644\u0627\u0641 \u062d\u062c\u0645 \u0627\u0644\u062c\u0645\u0647\u0631\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u0627\u0644\u062a\u063a\u0627\u064a\u0631\u064a\u0629 \u0628\u064a\u0646\u0647\u0627 \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u0627\u0644\u0644\u0627\u062c\u064a\u0646\u064a\u0629 \u0648\u0627\u062e\u062a\u0644\u0627\u0641 \u0645\u062f\u0651\u0629 \u0627\u0644\u062a\u062f\u0627\u0648\u064a \u0628\u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0648\u0627\u0644\u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0645\u062a\u0651\u0628\u0639\u0629 \u0641\u064a \u0627\u0644\u0645\u0646\u0627\u0637\u0631\u0629. \u064a\u0633\u062a\u062f\u0639\u064a \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0643\u0628\u064a\u0631 \u0644\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0627\u0644\u0645\u064f\u0644\u0627\u062d\u0638 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0627\u0644\u0645\u0646\u0627\u0637\u0631\u0629 \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0629 \u0648\u062a\u0642\u064a\u064a\u0645 \u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0626\u0631\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u062d\u0648\u0644 \u062f\u0648\u0646 \u0627\u0633\u062a\u0645\u0631\u0627\u0631 \u0627\u0644\u0645\u0631\u064a\u0636 \u0641\u064a \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0648\u062a\u062f\u0647\u0648\u0631 \u062d\u0627\u0644\u062a\u0647 \u0627\u0644\u0635\u062d\u064a\u0629 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0648\u0627\u0644\u0646\u0641\u0633\u064a\u0629 \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062e\u0635\u0648\u0635. \u064a\u064f\u0633\u062a\u0642\u0644\u0628 \u0631\u064a\u0633\u0628\u064a\u0631\u064a\u062f\u0648\u0646 \u0628\u0634\u0643\u0644 \u0623\u0639\u0638\u0645\u064a \u0628\u062a\u0648\u0627\u0633\u0637 \u0625\u0646\u0632\u064a\u0645 CYP2D6 \u0648\u0628\u062f\u0631\u062c\u0629 \u0623\u0642\u0644 \u0628\u062a\u0648\u0627\u0633\u0637 \u0625\u0646\u0632\u064a\u0645\u064a CYP3A4 \u0648CYP3A5. (27) \u0645\u0646 \u0627\u0644\u0634\u0627\u0626\u0639 \u0645\u0634\u0627\u0631\u0643\u0629 \u0631\u064a\u0633\u0628\u064a\u0631\u062f\u0648\u0646 \u0645\u0639 \u0623\u062f\u0648\u064a\u0629 \u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0630\u0647\u0627\u0646 \u0623\u0648 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0627\u0643\u062a\u0626\u0627\u0628 \u0623\u0648 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0635\u0631\u0639 \u0648\u0642\u062f \u064a\u0646\u062c\u0645 \u0639\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0627\u062a \u062a\u0622\u062b\u0631\u0627\u062a \u062f\u0648\u0627\u0626\u064a\u0629 \u0630\u0627\u062a \u0623\u0647\u0645\u064a\u0629 \u0633\u0631\u064a\u0631\u064a\u0629. 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<br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=1811\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":1820,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-1811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-154","volume-9","year-149"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/1811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1811"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/1811\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/1820"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}