{"id":183,"date":"2022-04-01T16:53:44","date_gmt":"2022-04-01T16:53:44","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=183"},"modified":"2024-07-21T17:47:47","modified_gmt":"2024-07-21T17:47:47","slug":"%d8%aa%d9%82%d8%b5%d9%8a-%d8%a7%d9%84%d9%81%d8%b9%d8%a7%d9%84%d9%8a%d8%a9-%d8%a7%d9%84%d9%85%d8%ab%d8%a8%d8%b7%d8%a9-%d9%84%d8%a3%d9%86%d8%b2%d9%8a%d9%85-%d8%a7%d9%84%d9%84%d9%8a%d8%a8%d8%a7%d8%b2","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=183","title":{"rendered":"\u062a\u0642\u0635\u064a \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0644\u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0644\u0639\u062f\u0629 \u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u062c\u0646\u0633\u064a \u0627\u0644\u0632\u0639\u0631\u0648\u0631 \u0648\u0627\u0644\u0639\u0644\u064a\u0642 \u0641\u064a \u0633\u0648\u0631\u064a\u0627 \u0648\u0639\u0632\u0644 \u0648\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0641\u0639\u0627\u0644"},"content":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction:<\/span><\/strong><\/p>\n

\u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062a\u0631\u0627\u0643\u0645 \u0632\u0627\u0626\u062f \u0623\u0648 \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a \u0644\u0644\u062f\u0633\u0645 \u0641\u064a \u0627\u0644\u062c\u0633\u0645\u060c \u064a\u0646\u062a\u062c \u0639\u0646 \u0639\u062f\u0645 \u0627\u0644\u062a\u0648\u0627\u0632\u0646 \u0628\u064a\u0646 \u0643\u0645\u064a\u0629 \u0627\u0644\u0637\u0639\u0627\u0645 \u0627\u0644\u0645\u062a\u0646\u0627\u0648\u0644\u0629\u060c \u0648\u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0645\u0635\u0631\u0648\u0641\u0629. \u0648\u0647\u064a \u062a\u0632\u062f\u0627\u062f \u0628\u0633\u0631\u0639\u0629 \u0645\u0642\u0644\u0642\u0629 \u0641\u064a \u062f\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645 \u0627\u0644\u0645\u062a\u0637\u0648\u0631\u0629\u060c \u0628\u0633\u0628\u0628 \u062a\u0646\u0627\u0648\u0644 \u0627\u0644\u0648\u062c\u0628\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0648\u0627\u0644\u0645\u0635\u0646\u0639\u0629 \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0628\u062f\u0646\u064a. \u064a\u0624\u062f\u064a \u062a\u062b\u0628\u064a\u0637 \u0639\u0645\u0644 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0625\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u062f\u0647\u0648\u0646 \u0645\u0646 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 \u0643\u0645\u064a\u0629 \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0645\u0643\u062a\u0633\u0628\u0629\u060c \u0648\u0645\u0646 \u062b\u0645\u0651 \u0645\u0646 \u0627\u0643\u062a\u0633\u0627\u0628 \u0627\u0644\u0633\u0639\u0631\u0627\u062a \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u0631\u063a\u0648\u0628 \u0641\u064a\u0647\u0627 (Seyedan et al.) (Spiegelman and Flier) (Roh and Jung) <\/span>\u0627\u0644\u0639\u0644\u064a\u0642 Rubus:<\/em> \u064a\u0639\u0631\u0641 \u0628\u0627\u0644\u0627\u0646\u0643\u0644\u064a\u0632\u064a\u0629 \u0628 Raspberries \u0623\u0648Blackberries \u00a0\u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0634\u062c\u064a\u0631\u0629 \u0623\u0648 \u0639\u0634\u0628\u0629 \u0645\u0639\u0645\u0631\u0629\u060c \u0645\u0646\u0647\u0627 \u0645\u062a\u0633\u0627\u0642\u0637\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0642 \u0648\u0645\u0646\u0647\u0627 \u062a\u0642\u0631\u064a\u0628\u0627\u064b \u062f\u0627\u0626\u0645\u0629 \u0627\u0644\u062e\u0636\u0631\u0629\u060c \u0639\u0627\u062f\u0629 \u0644\u0647\u0627 \u0623\u0634\u0648\u0627\u0643\u060c \u0628\u0639\u0636 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0645\u0632\u0631\u0648\u0639\u0629 \u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0634\u0648\u0627\u0643\u060c \u0627\u0644\u0633\u0627\u0642 \u0645\u062a\u0634\u0627\u0628\u0643\u0629 \u062a\u0646\u0645\u0648 \u0628\u0633\u0631\u0639\u0629 \u0648\u0642\u062f \u064a\u0635\u0644 \u0637\u0648\u0644\u0647\u0627 \u0625\u0644\u0649 7 \u0645\u062a\u0631. \u0648\u0647\u0648 \u0646\u0628\u0627\u062a \u0648\u0627\u0633\u0639 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0639\u0627\u0644\u0645\u064a \u0627\u060c\u064b \u0628\u0623\u0646\u0648\u0627\u0639\u0647 \u0627\u0644\u0628\u0631\u064a\u0629 \u0648\u0627\u0644\u0645\u0632\u0631\u0648\u0639\u0629\u060c \u064a\u0639\u062a\u0642\u062f \u0623\u0646 \u0627\u0644\u0645\u0648\u0637\u0646 \u0627\u0644\u0623\u0635\u0644\u064a \u0644\u0647 \u0647\u0648 \u0623\u0631\u0645\u064a\u0646\u064a\u0627. \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0644\u0623\u0648\u0631\u0627\u0642 \u0646\u0628\u0627\u062a \u0627\u0644\u0639\u0644\u064a\u0642 \u0627\u0644\u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0639\u062f\u064a\u062f\u0629 \u0627\u0644\u0641\u064a\u0646\u0648\u0644 (Schulz et al.) \u0641\u0639\u0627\u0644\u064a\u0629 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629\u060c \u0648\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0648\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0648\u062e\u0627\u0641\u0636\u0629 \u0644\u0633\u0643\u0631 \u0627\u0644\u062f\u0645\u060c \u0648\u0644\u0647 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u0635\u062d\u0629 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u0648\u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a\u060c \u0648\u062a\u0639\u062a\u0628\u0631 \u0627\u0644\u0623\u0644\u064a\u0627\u0641 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0646\u0628\u0627\u062a \u0623\u062d\u062f \u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0633\u062a\u0641\u064a\u062f \u0645\u0646\u0647\u0627 \u0645\u0631\u064a\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u0644\u0644\u062d\u062f \u0645\u0646 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0633\u0643\u0631\u064a\u0627\u062a (Tallini et al.). (Marulanda et al.) <\/span>\u0627\u0644\u0632\u0639\u0631\u0648\u0631 Crataegus <\/em>\u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0623\u0634\u062c\u0627\u0631 \u0635\u063a\u064a\u0631\u0629 \u0623\u0648 \u0634\u062c\u064a\u0631\u0627\u062a\u060c \u0645\u062a\u0633\u0627\u0642\u0637\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0642\u060c \u062a\u0645\u0644\u0643 \u0623\u0634\u0648\u0627\u0643\u0627\u064b \u0628\u0634\u0643\u0644 \u0639\u0627\u0645\u060c \u0648\u0647\u0648 \u0646\u0628\u0627\u062a \u0648\u0627\u0633\u0639 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0641\u064a \u0646\u0635\u0641 \u0627\u0644\u0643\u0631\u0629 \u0627\u0644\u0634\u0645\u0627\u0644\u064a (\u0622\u0633\u064a\u0627 \u0648\u0623\u0648\u0631\u0648\u0628\u0627 \u0648\u0623\u0645\u0631\u064a\u0643\u0627 \u0627\u0644\u0634\u0645\u0627\u0644\u064a\u0629)\u060c \u0627\u0633\u062a\u064f\u0639\u0645\u0644 \u063a\u0630\u0627\u0621 \u0648\u0641\u064a \u0627\u0644\u0637\u0628 \u0644\u0645\u0626\u0627\u062a \u0627\u0644\u0633\u0646\u064a\u0646 \u0641\u064a \u0623\u0648\u0631\u0648\u0628\u0627 \u0648\u0627\u0644\u0635\u064a\u0646. \u0627\u0644\u0627\u0633\u0645 \u0645\u0634\u062a\u0642 \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0629 \u0627\u0644\u064a\u0648\u0646\u0627\u0646\u064a\u0629 \u00a0Kratos \u0648\u0627\u0644\u062a\u064a \u062a\u0639\u0646\u064a \u0635\u0644\u0627\u0628\u0629 \u0627\u0644\u062e\u0634\u0628.(Kumar et al.)\u00a0 \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0644\u0623\u0648\u0631\u0627\u0642 \u0646\u0628\u0627\u062a \u0627\u0644\u0632\u0639\u0631\u0648\u0631 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0635\u062d\u064a\u0629 \u0648\u0645\u0646\u0647\u0627 \u062e\u0627\u0641\u0636\u0629 \u0644\u0644\u0634\u062d\u0648\u0645 \u0648\u062e\u0627\u0641\u0636\u0629 \u0644\u0644\u0633\u0643\u0631 \u0648\u062e\u0627\u0641\u0636\u0629 \u0644\u0644\u0636\u063a\u0637 \u0648\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629 \u0648\u0645\u0636\u0627\u062f\u0629 \u0644\u0642\u0635\u0648\u0631 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0627\u062d\u062a\u0642\u0627\u0646\u064a \u0648\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 (Liu) (Kumar et al.) (Long et al.).(Degenring et al.)<\/span><\/p>\n

\u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0644\u0646\u0628\u0627\u062a \u0627\u0644\u0639\u0644\u064a\u0642<\/strong> Chemical composition of Rubus<\/em><\/strong>:<\/em><\/strong><\/span><\/p>\n

\u0641\u0644\u0627\u0641\u0648\u0646\u0648\u0626\u064a\u062f\u0627\u062a: \u0623\u0647\u0645\u0647\u0627 \u0627\u0644\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646 Quercetin \u0648\u0627\u0644\u0647\u064a\u0628\u0631\u0648\u0632\u064a\u062f Hyperoside \u0648\u0627\u0644\u0643\u0627\u0645\u0641\u064a\u0631\u0648\u0644 Kaempferol \u0648\u0627\u0644\u0645\u064a\u0631\u0633\u062a\u064a\u0646 Myricitin \u0648\u0627\u0644\u0643\u0627\u062a\u0634\u064a\u0646 Catechin \u0648\u0627\u0644\u0625\u064a\u0628\u064a\u0643\u0627\u062a\u0634\u064a\u0646 Epicatechin \u0648\u0627\u0644\u0628\u0631\u0648\u0633\u064a\u0627\u0646\u064a\u062f\u064a\u0646 Procyanidin \u0648\u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0645\u0634\u062a\u0642\u0629 \u0645\u0646\u0647\u0627. <\/span>\u062d\u0645\u0648\u0636 \u0641\u064a\u0646\u0648\u0644\u064a\u0629: \u0623\u0647\u0645\u0647\u0627 \u062d\u0645\u0636 \u0627\u0644\u063a\u0627\u0644\u064a\u0643 acid Gallic \u0648\u062d\u0645\u0636 \u0627\u0644\u0625\u0644\u0627\u062c\u064a\u0643 Ellagic acid \u0648\u062d\u0645\u0636 \u0627\u0644\u0643\u0627\u0641\u064a\u0626\u064a\u0643 Caffeic acid \u0648\u062d\u0645\u0636 \u0628\u0627\u0631\u0627\u0643\u0648\u0645\u0627\u0631\u064a\u0643 p-coumaric acid. <\/span>\u062a\u0627\u0646\u064a\u0646\u0627\u062a: \u063a\u0627\u0644\u064a \u062a\u0627\u0646\u064a\u0646 Gallotannin \u0648\u0625\u0644\u0627\u063a\u064a \u062a\u0627\u0646\u064a\u0646 Ellagitannin. <\/span>\u0623\u062d\u0645\u0627\u0636 \u062b\u0644\u0627\u062b\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0646: \u0645\u062b\u0644 \u062d\u0645\u0636 \u0627\u0644\u0631\u0648\u0628\u0648\u062a\u064a\u0643 Rubutic acid \u0648\u062d\u0645\u0636 \u0627\u0644\u0631\u0648\u0628\u064a\u0646\u064a\u0643 Rubinic acid \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u0648\u0631\u0633\u0648\u0644\u064a\u0643 Ursolic acid \u0648\u0627\u0644\u0628\u064a\u062a\u0627 \u0623\u0645\u064a\u0631\u064a\u0646 \u03b2-amyrin. <\/span>\u0645\u0643\u0648\u0646\u0627\u062a \u0623\u062e\u0631\u0649: \u0645\u0643\u0648\u0646\u0627\u062a \u0637\u064a\u0627\u0631\u0629 Volatile components \u0648\u0641\u064a\u062a\u0627\u0645\u064a\u0646\u0627\u062a Vitamins \u0648\u0645\u0639\u0627\u062f\u0646 Minerals \u0648\u0633\u062a\u064a\u0631\u0648\u0626\u064a\u062f\u0627\u062a Steroids \u0648\u062a\u0631\u0628\u064a\u0646\u0648\u0626\u064a\u062f\u0627\u062aTerpenes .(Barnes et al.) (Zia-Ul-Haq et al.) (Rocabado et al.)<\/span><\/p>\n

\u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0644\u0646\u0628\u0627\u062a \u0627\u0644\u0632\u0639\u0631\u0648\u0631 <\/strong>Chemical composition of Crataegus<\/strong>:<\/strong><\/span><\/p>\n

\u0623\u0645\u064a\u0646\u0627\u062a: \u0641\u064a\u0646\u064a\u0644 \u0625\u064a\u062a\u064a\u0644 \u0623\u0645\u064a\u0646 Phenylethylamine \u0648 O – \u0645\u064a\u062a\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0625\u064a\u062a\u064a\u0644 \u0623\u0645\u064a\u0646 O-methoxyphenethylamine \u0648\u062a\u064a\u0631\u0627\u0645\u064a\u0646 Tyramine \u0648\u0627\u0644\u0643\u0648\u0644\u064a\u0646 Choline \u0648\u0627\u0644\u0623\u0633\u062a\u064a\u0644 \u0643\u0648\u0644\u064a\u0646 Acetylcholine \u0648\u0645\u0634\u062a\u0642\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0631\u064a\u0646 Purine. <\/span>\u0641\u0644\u0627\u0641\u0648\u0646\u0648\u0626\u064a\u062f\u0627\u062a: \u0645\u062b\u0644 \u0627\u0644\u0643\u0627\u0645\u0628\u0641\u064a\u0631\u0648\u0644 Kaempferol \u0648\u0627\u0644\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646 Quercetin \u0648\u0627\u0644\u0623\u064a\u0632\u0648\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646 Isoquercetin \u0648\u0627\u0644\u0631\u0648\u062a\u064a\u0646 Rutin \u0648\u0627\u0644\u0623\u0628\u064a\u062c\u064a\u0646\u064a\u0646 Apigenin \u0648\u0627\u0644\u0625\u064a\u0628\u064a\u0643\u0627\u062a\u0634\u064a\u0646 Epicatechin \u0648\u0627\u0644\u0644\u064a\u062a\u0648\u0644\u064a\u0646 Luteolin \u0648\u0627\u0644\u0631\u0648\u062a\u064a\u0646 Rutin \u0648\u0627\u0644\u0647\u064a\u0628\u0631\u0648\u0632\u064a\u062f Hyperoside \u0648\u0627\u0644\u0641\u064a\u062a\u0643\u0633\u064a\u0646 Vitexin \u0648\u0627\u0644\u0623\u0648\u0631\u064a\u0646\u062a\u064a\u0646 Orientin \u0648\u0633\u064a\u0643\u0633\u0627\u0646\u063a\u0648\u0644\u0627\u0631\u062a\u064a\u0646 Sexangularetin \u0648\u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0645\u0634\u062a\u0642\u0629 \u0645\u0646\u0647\u0627. <\/span>\u062a\u0627\u0646\u064a\u0646\u0627\u062a: \u0628\u0631\u0648\u0623\u0646\u062a\u0648\u0633\u064a\u0627\u0646\u064a\u0646 Proanthocyanins. <\/span>\u0623\u062d\u0645\u0627\u0636 \u0641\u064a\u0646\u0648\u0644\u064a\u0629: \u0623\u0647\u0645\u0647\u0627 \u062d\u0645\u0636 \u0627\u0644\u0643\u0644\u0648\u0631\u0648\u062c\u064a\u0646\u064a\u0643 Chlorogenic acid \u0648\u062d\u0645\u0636 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u0648\u0631\u0648\u062c\u064a\u0646\u064a\u0643 Neochlorogenic acid \u0648\u062d\u0645\u0636 \u0627\u0644\u063a\u0627\u0644\u064a\u0643 Gallic acid \u0648\u062d\u0645\u0636 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0628\u0646\u0632\u0648\u0626\u064a\u0643 Hydroxybenzoic acid. <\/span>\u0623\u062d\u0645\u0627\u0636 \u062b\u0644\u0627\u062b\u064a\u0629 \u0627\u0644\u062a\u0631\u0628\u064a\u0646: \u0623\u0647\u0645\u0647\u0627 \u062d\u0645\u0636 \u0627\u0644\u0623\u0648\u0644\u064a\u0627\u0646\u0648\u0644\u064a\u0643 Oleanolic acid \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u0648\u0631\u0633\u0648\u0644\u064a\u0643 Ursolic acid. <\/span>\u0645\u0643\u0648\u0646\u0627\u062a \u0623\u062e\u0631\u0649: \u063a\u0644\u064a\u0643\u0648\u0632\u064a\u062f\u0627\u062a \u0633\u064a\u0627\u0646\u0648\u062c\u064a\u0646\u064a\u0629 Cyanogenetic \u0648\u0635\u0627\u0628\u0648\u0646\u064a\u0646\u0627\u062a Saponins \u00a0(Barnes et al.) (Gruenwald et al.) (Edwards et al.) (Liu) (Kumar et al.).<\/span><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong>Materials and methods<\/strong>:<\/strong><\/span><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f Materials:<\/span><\/strong><\/p>\n

\u0645\u064a\u062a\u0627\u0646\u0648\u0644 Methanol \u0634\u0631\u0643\u0629Fluka chemika\u060cDimethyl sulfoxide (DMSO)\u060c \u0645\u0627\u0621 \u0645\u0642\u0637\u0631Distilled water\u060c \u062e\u0644\u0627\u062a \u0627\u0644\u0625\u064a\u062a\u064a\u0644 Ethel acetate \u0634\u0631\u0643\u0629Merck\u060c \u0625\u064a\u062a\u0631 \u0625\u064a\u062a\u064a\u0644\u064a Diethyl ether \u0634\u0631\u0643\u0629Merck\u060c \u0623\u0648\u0631\u0644\u064a\u0633\u062a\u0627\u062a Orlistat \u0634\u0631\u0643\u0629 Sigma Aldrich\u060c \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 Lipase enzyme \u0634\u0631\u0643\u0629Sigma Aldrich\u060c 4 -\u0646\u062a\u0631\u0648\u0641\u064a\u0646\u064a\u0644 \u0623\u0648\u0643\u062a\u0627\u0646\u0648\u0627\u062a 4-nitrophenyl octanoate \u0634\u0631\u0643\u0629Sigma Aldrich.<\/span><\/p>\n

\u0627\u0644\u0623\u062c\u0647\u0632\u0629Equipments:<\/span><\/strong><\/p>\n

\u0645\u0637\u062d\u0646\u0629 \u0644\u062a\u0646\u0639\u064a\u0645 \u0627\u0644\u0646\u0628\u0627\u062a\u0627\u062a Molineux\u060c \u0628\u0631\u0627\u062f \u0644\u062d\u0641\u0638 \u0627\u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0627\u0644\u0646\u0628\u0627\u062a\u064a\u0629 Kelvinator\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0636\u0648\u0626\u064a uv\/vis Spectrophotometer \u0645\u0646 \u0646\u0648\u0639 SP-3000 Plus OPTIMA TOKYO,JAPAN\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0628\u062e\u0631 \u0627\u0644\u062f\u0648\u0627\u0631 Rotary evaporator \u0645\u0646 \u0646\u0648\u0639 BuchiRotavapor R-205\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0627\u0644\u062a\u062d\u0636\u064a\u0631\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 Preparative high performance Liquid Chromatography \u0646\u0648\u0639 JASCO-LC-1500\u060c \u062c\u0647\u0627\u0632 \u0645\u0637\u064a\u0627\u0641\u064a\u0629 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0646\u0648\u0639 JASCO 300E\u060c \u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0643\u062a\u0644\u0629 Mass Spectroscopy \u0646\u0648\u0639 Shimadzu LC2020\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a Nuclear Magnetic Resonance \u0646\u0648\u0639 Avance 400MHz Bruker, Germany.<\/span><\/p>\n

\u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0628\u0627\u062a\u064a\u0629 <\/strong>Collection of plant material<\/strong>:<\/strong><\/span><\/p>\n

\u062a\u0645 \u062c\u0645\u0639 Collecting \u0623\u0648\u0631\u0627\u0642 \u0646\u0628\u0627\u062a\u0627\u062a \u062c\u0646\u0633\u064a \u0627\u0644\u0639\u0644\u064a\u0642 Rubus <\/em>\u0648\u0627\u0644\u0632\u0639\u0631\u0648\u0631 Crataegus <\/em>\u0641\u064a \u0634\u0647\u0631\u064a \u0646\u064a\u0633\u0627\u0646 \u0648\u062a\u0634\u0631\u064a\u0646 \u0627\u0644\u0623\u0648\u0644\u060c \u0645\u0646 \u0639\u062f\u0629 \u0645\u0646\u0627\u0637\u0642 \u0641\u064a \u0633\u0648\u0631\u064a\u0627 \u0641\u064a \u0627\u0644\u0635\u0628\u0627\u062d \u0627\u0644\u0628\u0627\u0643\u0631 \u0648\u0647\u0630\u0647 \u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u0647\u064a: \u0631\u064a\u0641 \u062d\u0645\u0635 (\u0648\u0627\u062f\u064a \u0627\u0644\u0646\u0636\u0627\u0631\u0629)\u060c \u0631\u064a\u0641 \u0637\u0631\u0637\u0648\u0633 (\u0635\u0627\u0641\u064a\u062a\u0627)\u060c \u0631\u064a\u0641 \u0627\u0644\u0644\u0627\u0630\u0642\u064a\u0629 (\u0645\u0634\u0642\u064a\u062a\u0627). <\/span>\u062d\u064a\u062b \u062c\u064f\u0645\u0639\u062a \u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u062c\u0646\u0633 \u0627\u0644\u0639\u0644\u064a\u0642 \u0648\u0646\u0648\u0639\u064a\u0646 \u0645\u0646 \u062c\u0646\u0633 \u0627\u0644\u0632\u0639\u0631\u0648\u0631 \u0648\u0647\u064a:<\/span><\/p>\n

    \n
  1. Rubus sanctus<\/em><\/span><\/li>\n
  2. Rubus collinus<\/em><\/span><\/li>\n
  3. Rubus hedycarpus<\/em><\/span><\/li>\n
  4. Crataegus monogyna<\/em><\/span><\/li>\n
  5. Crataegus azarolus var. aronia<\/em><\/span><\/li>\n<\/ol>\n

    \u0648\u0635\u0641 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0628\u0646\u0627\u062a\u064a\u0629<\/strong>Species description<\/strong>:<\/strong><\/span><\/p>\n

      \n
    1. Rubus sanctus<\/em><\/span><\/li>\n<\/ol>\n

      \u0639\u0634\u0628\u0629 \u0645\u0639\u0645\u0631\u0629\u060c \u062f\u0627\u0626\u0645\u0629 \u0627\u0644\u062e\u0636\u0631\u0629 \u062a\u0642\u0631\u064a\u0628\u0627.\u064b \u0627\u0644\u0633\u0627\u0642 \u0642\u0648\u064a\u0629 \u0645\u0642\u0648\u0633\u0629 \u0623\u0648 \u0645\u0633\u0637\u062d\u0629\u060c \u062d\u0645\u0631\u0627\u0621 \u0627\u0644\u0644\u0648\u0646. \u0627\u0644\u0623\u0648\u0631\u0627\u0642 \u0645\u0631\u0643\u0628\u0629\u060c \u0645\u062d\u062f\u0628\u0629\u060c \u0645\u0633\u0646\u0646\u0629 \u0628\u0623\u0634\u0643\u0627\u0644 \u0645\u062e\u062a\u0644\u0641\u0629\u060c \u0645\u0642\u0633\u0645\u0629 \u0628\u0634\u0643\u0644 \u0643\u0641\u064a\u060c \u0627\u0644\u0648\u0631\u064a\u0642\u0627\u062a 3 – 5. \u0627\u0644\u0623\u0634\u0648\u0627\u0643 \u0642\u0648\u064a\u0629\u060c \u0648\u0627\u0633\u0639\u0629 \u0627\u0644\u0642\u0627\u0639\u062f\u0629\u060c \u0628\u0627\u0631\u0632\u0629 \u0648\u0645\u0639\u0642\u0648\u0641\u0629. \u0627\u0644\u0633\u0628\u0644\u0627\u062a \u0628\u064a\u0636\u0627\u0621 \u0648\u0628\u0631\u064a\u0629 \u062a\u0646\u062d\u0646\u064a \u0628\u0639\u062f \u0627\u0644\u0625\u0632\u0647\u0627\u0631. \u0627\u0644\u0628\u062a\u0644\u0627\u062a 5 \u0645\u062c\u0639\u062f\u0629\u060c \u062f\u0627\u0626\u0631\u064a\u0629 \u0623\u0648 \u0628\u064a\u0636\u0648\u064a\u0629\u060c \u0623\u062d\u064a\u0627\u0646\u0627 \u0645\u0633\u0646\u0646\u0629 \u0639\u0646\u062f \u0627\u0644\u0642\u0645\u0629\u060c \u0632\u0647\u0631\u064a\u0629 \u0623\u0648 \u0623\u062d\u064a\u0627\u0646\u0627 \u0628\u064a\u0636\u0627\u0621. \u0627\u0644\u062b\u0645\u0627\u0631 \u0644\u062d\u0645\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u0633\u0648\u062f\u0627\u0621 \u0627\u0644\u0644\u0648\u0646. (Paul mouterde) (Tutin et al.) (Zia-Ul-Haq et al.)<\/span><\/p>\n

        \n
      1. Rubus collinus<\/em><\/span><\/li>\n<\/ol>\n

        \u0639\u0634\u0628\u0629 \u0645\u0639\u0645\u0631\u0629\u060c \u062f\u0627\u0626\u0645\u0629 \u0627\u0644\u062e\u0636\u0631\u0629 \u062a\u0642\u0631\u064a\u0628\u0627.\u064b \u0627\u0644\u0633\u0627\u0642 \u0645\u0642\u0648\u0633\u0629\u060c \u0645\u0633\u062a\u0644\u0642\u064a\u0629 \u0623\u0648 \u0646\u0635\u0641 \u0645\u0646\u062a\u0635\u0628\u0629. \u0627\u0644\u0623\u0648\u0631\u0627\u0642 \u0645\u062a\u0628\u0627\u062f\u0644\u0629\u060c \u0645\u0631\u0643\u0628\u0629\u060c \u0635\u063a\u064a\u0631\u0629\u060c \u0627\u0644\u0648\u0631\u064a\u0642\u0627\u062a 3 – 5. \u0627\u0644\u0623\u0634\u0648\u0627\u0643 \u0645\u0646\u062d\u0646\u064a\u0629 \u0628\u0642\u0648\u0629. \u0627\u0644\u0628\u062a\u0644\u0627\u062a 5 \u0635\u063a\u064a\u0631\u0629 \u0628\u064a\u0636\u0627\u0648\u064a\u0629 \u0645\u062a\u0637\u0627\u0648\u0644\u0629\u060c \u0628\u064a\u0636\u0627\u0621 \u0627\u0644\u0644\u0648\u0646. \u0627\u0644\u062b\u0645\u0627\u0631 \u0635\u063a\u064a\u0631\u0629 \u0633\u0648\u062f\u0627\u0621 \u0639\u0646\u062f \u0627\u0644\u0646\u0636\u062c. (Paul mouterde) (Tutin et al.) (Zia-Ul-Haq et al.)<\/span><\/p>\n

          \n
        1. Rubus hedycarpus<\/em>:<\/em><\/span><\/li>\n<\/ol>\n

          \u0639\u0634\u0628\u0629 \u0645\u0639\u0645\u0631\u0629\u060c \u062f\u0627\u0626\u0645\u0629 \u0627\u0644\u062e\u0636\u0631\u0629 \u062a\u0642\u0631\u064a\u0628\u0627.\u064b \u0627\u0644\u0633\u0627\u0642 \u0645\u062a\u0641\u0631\u0639\u0629 \u0643\u062b\u064a\u0631\u0627\u064b\u060c \u062b\u062e\u064a\u0646\u0629\u060c \u062d\u0645\u0631\u0627\u0621 \u0628\u0646\u064a\u0629 \u0627\u0644\u0644\u0648\u0646. \u0627\u0644\u0623\u0648\u0631\u0627\u0642 \u0643\u0641\u064a\u0629 \u0645\u0631\u0643\u0628\u0629\u060c \u0645\u0642\u0633\u0645\u0629 \u0625\u0644\u0649 3-5 \u0648\u0631\u064a\u0642\u0627\u062a \u0645\u0633\u0646\u0646\u0629. \u0627\u0644\u0623\u0634\u0648\u0627\u0643 \u0628\u0627\u0631\u0632\u0629 \u0637\u0648\u064a\u0644\u0629 \u0648\u0642\u0648\u064a\u0629. \u0627\u0644\u0628\u062a\u0644\u0627\u062a5 \u00a0\u0643\u0628\u064a\u0631\u0629\u060c \u0634\u0628\u0647 \u0628\u064a\u0636\u0648\u064a\u0629\u060c \u0632\u0647\u0631\u064a\u0629 \u0623\u0648 \u062d\u0645\u0631\u0627\u0621 \u0627\u0644\u0644\u0648\u0646. \u0648\u062a\u062f\u0639\u0649 \u0627\u0644\u062b\u0645\u0627\u0631 \u0628\u0627\u0644\u062a\u0648\u062a \u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0642\u0637\u0631\u0627\u062a \u0644\u062d\u0645\u064a\u0629 \u0635\u063a\u064a\u0631\u0629. (Paul mouterde) (Tutin et al.) (Zia-Ul-Haq et al.)<\/span><\/p>\n

            \n
          1. :Crataegus monogyna <\/em><\/span><\/li>\n<\/ol>\n

            \u0634\u062c\u0631\u0629 \u0635\u063a\u064a\u0631\u0629 \u0623\u0648 \u0634\u062c\u064a\u0631\u0629 \u0637\u0648\u0644\u0647\u0627 \u063a\u0627\u0644\u0628\u0627 2 – 4 \u0645\u060c \u0645\u062a\u0633\u0627\u0642\u0637\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0642. \u0627\u0644\u0623\u0634\u0648\u0627\u0643 \u062d\u0627\u062f\u0629 \u0637\u0648\u0644\u0647\u0627 7 – 20 \u0645\u0645. \u0627\u0644\u0623\u0648\u0631\u0627\u0642 \u0628\u0633\u064a\u0637\u0629 \u0628\u064a\u0636\u0648\u064a\u0629 \u0645\u0642\u0644\u0648\u0628\u0629\u060c \u0645\u062a\u0646\u0627\u0648\u0628\u0629\u060c \u0644\u0647\u0627 3 – 7 \u0641\u0635\u0648\u0635. \u0627\u0644\u0633\u0628\u0644\u0627\u062a 5 \u0645\u0644\u062a\u062d\u0645\u0629\u060c \u0627\u0644\u0628\u062a\u0644\u0627\u062a 5 \u062d\u0631\u0629 \u0628\u064a\u0636\u0627\u0621 \u0627\u0644\u0644\u0648\u0646\u060c \u0634\u0628\u0647 \u0645\u062f\u0648\u0631\u0629. \u0627\u0644\u062b\u0645\u0631\u0629 \u062d\u0645\u0631\u0627\u0621\u060c \u0634\u0628\u0647 \u0643\u0631\u0648\u064a\u0629 \u0628\u0642\u0637\u0631 5 – 11 \u0645\u0645\u060c \u062a\u062a\u0636\u0645\u0646 \u0646\u0648\u064a\u0629 \u0648\u062d\u064a\u062f\u0629 .(Nabavi et al.) (Albarouki and Peterson)<\/span><\/p>\n

              \n
            1. : Crataegus azarolus var. aronia<\/em><\/span><\/li>\n<\/ol>\n

              \u0634\u062c\u0631\u0629 \u0623\u0648 \u0634\u062c\u064a\u0631\u0629 \u0637\u0648\u0644\u0647\u0627 \u063a\u0627\u0644\u0628\u0627 4 – 8 \u0645\u060c \u0645\u062a\u0633\u0627\u0642\u0637\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0642. \u0627\u0644\u0623\u0634\u0648\u0627\u0643 \u0637\u0648\u064a\u0644\u0629 \u062d\u0627\u062f\u0629 \u0637\u0648\u0644\u0647\u0627 5 – 10 \u0645\u0645. \u0627\u0644\u0623\u0648\u0631\u0627\u0642 \u0628\u064a\u0636\u0648\u064a\u0629 \u0645\u0642\u0644\u0648\u0628\u0629\u060c \u0644\u0647\u0627 3 – 5 \u0641\u0635\u0648\u0635. \u0627\u0644\u0633\u0628\u0644\u0627\u062a 5 \u0645\u0644\u062a\u062d\u0645\u0629\u060c \u0627\u0644\u0628\u062a\u0644\u0627\u062a 5 \u062d\u0631\u0629 \u0628\u064a\u0636\u0627\u0621 \u0627\u0644\u0644\u0648\u0646. \u0627\u0644\u062b\u0645\u0631\u0629 \u0635\u0641\u0631\u0627\u0621\u060c \u0634\u0628\u0647 \u0643\u0631\u0648\u064a\u0629 \u0628\u0642\u0637\u0631 15 25-\u0645\u0645\u060c \u062a\u062a\u0636\u0645\u0646 2 – 3 \u0646\u0648\u064a\u0627\u062a) (Albarouki and Peterson) \u0623\u0643\u0633\u0627\u062f, 2012.<\/span><\/p>\n

              \u0627\u0644\u0627\u0633\u062a\u062e\u0644\u0627\u0635<\/strong> Extraction<\/strong>:<\/strong><\/span><\/p>\n

              \u062d\u064f\u0636\u0651\u0631\u062a \u062e\u0644\u0627\u0635\u0627\u062a \u0645\u064a\u062a\u0627\u0646\u0648\u0644\u064a\u0629 \u0645\u0646 \u0623\u0648\u0631\u0627\u0642 \u0627\u0644\u0646\u0628\u0627\u062a\u0627\u062a \u0648\u0641\u0642 \u0627\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629:<\/span><\/p>\n

              -\u062a\u0645 \u0648\u0632\u0646 \u0645\u0642\u062f\u0627\u0631 50 \u063a\u0631\u0627\u0645\u0627\u064b \u0645\u0646 \u0645\u0633\u0627\u062d\u064a\u0642 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u062c\u0627\u0641\u0629\u060c \u0648\u062a\u0645 \u0627\u0644\u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0628\u0627\u0644\u062a\u0639\u0637\u064a\u0646 \u0641\u064a 500 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u064a\u062a\u0627\u0646\u0648\u0644 \u0644\u0645\u062f\u0629 72 \u0633\u0627\u0639\u0629 \u0645\u0639 \u0627\u0644\u062a\u062d\u0631\u064a\u0643.<\/span><\/p>\n

              -\u062b\u0645 \u062a\u0631\u0634\u064a\u062d \u0627\u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0648\u062a\u062c\u0641\u064a\u0641\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0628\u062e\u0631 \u0627\u0644\u062f\u0648\u0627\u0631.<\/span><\/p>\n

              – \u0623\u0639\u064a\u062f\u062a \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a. \u062d\u064a\u062b \u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 10 \u062e\u0644\u0627\u0635\u0627\u062a \u062c\u0627\u0641\u0629 \u0647\u064a:<\/span><\/p>\n

              -\u062e\u0644\u0627\u0635\u062a\u0627\u0646 \u0644\u0644\u0646\u0648\u0639 Rubus sanctus <\/em>\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0628\u064a\u0639 \u0648\u0633\u0645\u064a\u062a RS.sp\u060c \u0648\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062e\u0631\u064a\u0641 \u0648\u0633\u0645\u064a\u062a RS.au<\/span><\/p>\n

              -\u062e\u0644\u0627\u0635\u062a\u0627\u0646 \u0644\u0644\u0646\u0648\u0639 Rubus collinus <\/em>\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0628\u064a\u0639 \u0648\u0633\u0645\u064a\u062a RC.sp \u00a0\u0648\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062e\u0631\u064a\u0641 \u0648\u0633\u0645\u064a\u062a RC.au<\/span><\/p>\n

              -\u062e\u0644\u0627\u0635\u062a\u0627\u0646 \u0644\u0644\u0646\u0648\u0639 Rubus hedycarpus <\/em>\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0628\u064a\u0639 \u0648\u0633\u0645\u064a\u062a RH.sp\u060c \u0648\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062e\u0631\u064a\u0641 \u0648\u0633\u0645\u064a\u062a RH.au<\/span><\/p>\n

              -\u062e\u0644\u0627\u0635\u062a\u0627\u0646 \u0644\u0644\u0646\u0648\u0639 Crataegus monogyna <\/em>\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0628\u064a\u0639 \u0648\u0633\u0645\u064a\u062a CM.sp\u060c \u0648\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062e\u0631\u064a\u0641 \u0648\u0633\u0645\u064a\u062aCM.au<\/span><\/p>\n

              -\u062e\u0644\u0627\u0635\u062a\u0627\u0646 \u0644\u0644\u0646\u0648\u0639 \u00a0Crataegus azarolus var.aronia<\/em> \u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0628\u064a\u0639 \u0648\u0633\u0645\u064a\u062a CA.sp\u060c \u0648\u0627\u0644\u0645\u062c\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062e\u0631\u064a\u0641 \u0648\u0633\u0645\u064a\u062a CA.au<\/span><\/p>\n

              -\u062b\u0645 \u062d\u064f\u0636\u0651\u0631\u062a \u0633\u0644\u0633\u0644\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 \u0644\u0643\u0644 \u062e\u0644\u0627\u0635\u0629 (25 – 50 – 100 -200 \u2013 400) \u0645\u0643\u063a\\\u0645\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 DMSO 10% \u0643\u0645\u062d\u0644.<\/span><\/p>\n

              \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632<\/strong>Determination of lipase inhibitory activity<\/strong>:<\/strong><\/span><\/p>\n

              \u064a\u062d\u0636\u0646 0.5 \u0645\u0644 \u0645\u0646 \u0643\u0644 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0648\u0627\u0644\u0623\u0648\u0631\u0644\u064a\u0633\u062a\u0627\u062a \u0636\u0645\u0646 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 (25 – 50 – 100 – 200 – 400) \u0645\u0643\u063a\\\u0645\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 10% DMSO \u0643\u0645\u062d\u0644\u060c \u0645\u0639 0.5 \u0645\u0644 \u0645\u0646 \u0623\u0646\u0632\u064a\u0645 \u0644\u064a\u0628\u0627\u0632 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0628\u062a\u0631\u0643\u064a\u0632 1 \u0645\u063a\\\u0645\u0644 \u0641\u064a \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a 0.1mM\u060c pH=6.0 \u0644\u0645\u062f\u0629 \u0633\u0627\u0639\u0629 \u0641\u064a \u062d\u0645\u0627\u0645 \u0645\u0627\u0626\u064a \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 30 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629\u060c \u0636\u0645\u0646 \u0648\u0633\u0637 \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a (0.1mM, pH 7.2, 0.1% Tween 80) \u062d\u064a\u062b \u062a\u0645 \u0625\u0636\u0627\u0641\u0629 3\u0645\u0644 \u0645\u0646 \u0627\u0644\u0648\u0642\u0627\u0621. \u0628\u0639\u062f \u0645\u0636\u064a \u0633\u0627\u0639\u0629 \u064a\u0636\u0627\u0641 200 \u0645\u064a\u0643\u0631\u0648\u0644\u062a\u0631 \u0645\u0646 \u0627\u0644\u0631\u0643\u0627\u0632\u0629 p-nitrophenyl octanoate (pNPO) \u0628\u062a\u0631\u0643\u064a\u0632 0.01M \u0641\u064a DMSO \u0625\u0644\u0649 \u0648\u0633\u0637 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u060c \u0648\u064a\u0646\u062a\u0638\u0631 \u0644\u0645\u062f\u0629 5 \u062f\u0642\u0627\u0626\u0642\u060c \u062b\u0645 \u062a\u0642\u0627\u0633 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u0646\u0632\u064a\u0645 \u0628\u0642\u064a\u0627\u0633 \u0627\u0645\u062a\u0635\u0627\u0635\u064a\u0629 \u0645\u0631\u0643\u0628 \u0628\u0627\u0631\u0627\u0646\u062a\u0631\u0648\u0641\u064a\u0646\u0648\u0644 p-nitropheol \u0630\u0648 \u0627\u0644\u0644\u0648\u0646 \u0627\u0644\u0623\u0635\u0641\u0631 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a spectrophotometer \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 410 \u0646\u0627\u0646\u0648\u0645\u062a\u0631. \u062d\u064f\u0636\u0651\u0631 \u0627\u0644\u0646\u0627\u0635\u0639 \u0645\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0643\u0648\u0627\u0634\u0641 \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0643\u0644\u064a \u0645\u0627 \u0639\u062f\u0627 \u0627\u0644\u0623\u0646\u0632\u064a\u0645 \u0627\u0633\u062a\u0628\u062f\u0644 \u0628\u0627\u0644\u0648\u0642\u0627\u0621\u060c \u0648\u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0623\u0648\u0631\u0644\u064a\u0633\u062a\u0627\u062a (\u0645\u062b\u0628\u0637 \u0645\u0639\u0631\u0648\u0641 \u0644\u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632) \u0639\u0644\u0649 \u0623\u0646\u0647 \u0634\u0627\u0647\u062f \u0625\u064a\u062c\u0627\u0628\u064a. \u062a\u0645 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a. \u062a\u0645 \u062d\u0633\u0627\u0628 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u062a\u062b\u0628\u064a\u0637 \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0648\u0627\u0644\u0623\u0648\u0631\u0644\u064a\u0633\u062a\u0627\u062a \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629:<\/span><\/p>\n

              \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u062a\u062b\u0628\u064a\u0637:<\/span><\/p>\n

              (ILipase<\/sub>%)= 100 \u2013 ((AsampleA<\/sub>\u2212 AsampleB<\/sub>)\/(Acontrol<\/sub> \u2013 AcontrolB<\/sub>) \u00d7 100)<\/span><\/p>\n

              \u062d\u064a\u062b Asample \u0634\u062f\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0639\u064a\u0646\u0629<\/span><\/p>\n

              \u00a0AsampleB \u0634\u062f\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0646\u0627\u0635\u0639 \u0644\u0644\u0639\u064a\u0646\u0629<\/span><\/p>\n

              \u00a0Acontrol \u0634\u062f\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0634\u0627\u0647\u062f \u0627\u0644\u0633\u0644\u0628\u064a<\/span><\/p>\n

              \u00a0AcontrolB \u0634\u062f\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0646\u0627\u0635\u0639 \u0644\u0644\u0634\u0627\u0647\u062f \u0627\u0644\u0633\u0644\u0628\u064a<\/span><\/p>\n

              \u0627\u0644\u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u0646\u0635\u0641\u064a 50IC: \u062c\u0631\u0649 \u062d\u0633\u0627\u0628 \u0627\u0644\u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u0646\u0635\u0641\u064a \u0644\u0643\u0644 \u0627\u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0642\u0627\u062f\u0631 \u0639\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 50% \u0645\u0646 \u0623\u0646\u0632\u064a\u0645<\/span><\/p>\n

              \u0644\u064a\u0628\u0627\u0632 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633\u060c \u062d\u064a\u062b \u0623\u0646\u0634\u0626\u062a \u0631\u0633\u0648\u0645 \u0628\u064a\u0627\u0646\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u062a\u0631\u0643\u064a\u0632)\u0645\u0643\u063a\\\u0645\u0644( \u0648 (ILipase%)\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c.Excel 2016<\/span><\/p>\n

              (Roh and Jung) (Gil-Rodr\u00edguez and Beresford) (Marmouzi et al.)<\/span><\/p>\n

              \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629<\/strong> Statistics study<\/strong>:<\/strong><\/span><\/p>\n

              \u062c\u0631\u0649 \u062d\u0633\u0627\u0628 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0644\u0646\u062a\u0627\u0626\u062c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c.Excel 2016<\/span><\/p>\n

              \u0639\u0632\u0644 \u0648\u062a\u062d\u062f\u064a\u062f \u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0641\u0639\u0627\u0644<\/strong>:Isolation and structure elucidation of active compound <\/strong><\/span><\/p>\n

              -\u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0627\u0644\u062a\u062d\u0636\u064a\u0631\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621HPLC preparative:<\/span><\/p>\n

              \u0623\u064f\u062c\u0631\u064a \u0627\u0644\u0639\u0632\u0644 \u0644\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0639\u0644\u0649 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0627\u0644\u062a\u062d\u0636\u064a\u0631\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0645\u062e\u0627\u0628\u0631 \u0647\u064a\u0626\u0629 \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u0629\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0645\u0648\u062f C18 150 \u00d7 21.2 \u0645\u0645\u060c 5 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631 \u0648\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0648\u0631 \u0645\u062a\u062d\u0631\u0643 \u064a\u062a\u0623\u0644\u0641 \u0645\u0646: \u0645\u062d\u0644 A: \u0645\u0627\u0621\u060c \u0645\u062d\u0644 B: \u0623\u0633\u064a\u062a\u0648\u0646\u062a\u0631\u064a\u0644. \u0648\u0628\u062a\u0637\u0628\u064a\u0642 \u0633\u0631\u0639\u0629 \u062a\u062f\u0641\u0642 2 \u0645\u0644\\\u062f\u0642\u064a\u0642\u0629 \u0648\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c \u0644\u0644\u0641\u0635\u0644 \u0645\u062a\u062f\u0631\u062c \u0643\u0645\u0627 \u064a\u0644\u064a: \u0645\u062d\u0644B 10% \u00a05 \u062f\u0642\u0627\u0626\u0642\u060c 30% 5 – 8 \u062f\u0642\u0627\u0626\u0642\u060c 100% 8 – 30 \u062f\u0642\u064a\u0642\u0629\u060c 10% 30 – 37 \u062f\u0642\u064a\u0642\u0629. \u0648\u0627\u0633\u062a\u064f\u062e\u062f\u0645 \u0643\u0627\u0634\u0641 UV \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 254 \u0646\u0627\u0646\u0648\u0645\u062a\u0631.<\/span><\/p>\n

              \u00a0-\u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621:FTIR spectrum<\/span><\/p>\n

              \u0633\u064f\u062c\u0651\u0644 \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0639\u0644\u0649 \u062c\u0647\u0627\u0632 Fourier-transform infrared spectroscopy (FTIR) \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0645\u062e\u0627\u0628\u0631 \u0647\u064a\u0626\u0629 \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u0629.<\/span><\/p>\n

              \u00a0-\u062a\u062d\u0631\u064a \u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0643\u062a\u0644\u0629:Mass spectroscopy Analyzing<\/span><\/p>\n

              \u062a\u0636\u0645\u0646\u062a \u0634\u0631\u0648\u0637 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0637\u064a\u0641\u064a \u0627\u0644\u0643\u062a\u0644\u064a \u0648\u0641\u0642 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a \u0644\u0644\u0623\u064a\u0648\u0646\u0627\u062a +] \u00a0[M+H\u0628\u0627\u0644\u0627\u0631\u0630\u0627\u0630 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a Electrospray ionization (ESI) \u062c\u0647\u062f \u0643\u0647\u0631\u0628\u0627\u0626\u064a \u0634\u0639\u0631\u064a capillary voltage \u064a\u0628\u0644\u063a 3500 \u0641\u0648\u0644\u062a\u060c \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u063a\u0627\u0632 \u0627\u0644\u062a\u0628\u062e\u064a\u0631 230 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629\u060c \u0633\u0631\u0639\u0629 \u062a\u062f\u0641\u0642 \u0627\u0644\u063a\u0627\u0632 10 \u0644\u062a\u0631\\\u062f\u0642\u064a\u0642\u0629\u060c \u0648\u0627\u0644\u0625\u0631\u0630\u0627\u0630 \u00a0nebulizer 50 PSI\u060c \u0648\u0642\u062f \u062a\u0645 \u0627\u0644\u0639\u0645\u0644 \u0641\u064a \u0645\u062e\u0627\u0628\u0631 \u0647\u064a\u0626\u0629 \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u0629.<\/span><\/p>\n

              \u00a0-\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a:NMR spectroscopy<\/span><\/p>\n

              \u062c\u0631\u0649 \u062a\u062d\u062f\u064a\u062f \u0635\u064a\u063a \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0648\u062a\u0633\u062c\u064a\u0644 \u0623\u0637\u064a\u0627\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u064a NMR-H1 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062d\u0644 DMSO \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 Avance 400MHz \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0645\u062e\u0627\u0628\u0631 \u0647\u064a\u0626\u0629 \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u0629\u060c \u0633\u064f\u062c\u0651\u0644\u062a \u0627\u0644\u0627\u0646\u0632\u064a\u0627\u062d\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 (\u03b4) \u0641\u064a \u0623\u062c\u0632\u0627\u0621 \u0627\u0644\u0645\u0644\u064a\u0648\u0646 (ppm) \u0646\u0633\u0628\u0629 \u0625\u0644\u0649 \u0625\u0634\u0627\u0631\u0629 \u062a\u062a\u0631\u0627\u0645\u064a\u062a\u064a\u0644 \u0633\u064a\u0644\u0627\u0646 (TMS) \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0643\u0639\u064a\u0627\u0631\u064a \u062f\u0627\u062e\u0644\u064a. <\/span>\u062a\u0645 \u062a\u0648\u0636\u064a\u062d \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u0627\u0646\u0632\u064a\u0627\u062d \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u0644\u062a\u0639\u062f\u062f\u064a\u0629\u060c \u0648\u062a\u0645 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646\u0647\u0627 \u0628\u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062a\u0627\u0644\u064a s \u0645\u0641\u0631\u062f\u0629\u060c d \u0645\u0632\u062f\u0648\u062c\u0629\u060c \u0648 t \u062b\u0644\u0627\u062b\u064a\u0629\u060c \u0648\u0647\u0643\u0630\u0627. \u062a\u0645 \u062a\u0633\u062c\u064a\u0644 \u0623\u0637\u064a\u0627\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064a 13<\/sup>NMR-C \u0645\u0639 \u0623\u0637\u064a\u0627\u0641(HMBC)\u060c (HSQC) \u060c(DEPT)\u060c (COSY) \u0623\u064a\u0636\u0627\u064b \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 Avance 400MHz.<\/span><\/p>\n

              \u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong>Results<\/strong>:<\/strong><\/span><\/p>\n

              – \u062a\u0631\u0627\u0648\u062d \u0645\u0631\u062f\u0648\u062f \u0627\u0644\u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0644\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u0646 1.1 \u063a\u0631\u0627\u0645 \u0625\u0644\u0649 3.3 \u063a\u0631\u0627\u0645\u060c \u0643\u0645\u0627 \u064a\u0638\u0647\u0631 \u062c\u062f\u0648\u0644 (1).<\/span><\/p>\n

              – \u062a\u0631\u0627\u0648\u062d\u062a \u0642\u064a\u0645 50<\/sub>IC \u0627\u0644\u0645\u0639\u0628\u0631\u0629 \u0639\u0646 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0644\u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0645\u0646 72 \u0625\u0644\u0649 215 \u0645\u0643\u063a\\\u0645\u0644\u060c \u0628\u064a\u0646\u0645\u0627 \u0623\u0639\u0637\u0649 \u0627\u0644\u0634\u0627\u0647\u062f \u0623\u0648\u0631\u0644\u064a\u0633\u062a\u0627\u062a \u0642\u064a\u0645\u0629\u00a0 IC50<\/sub>=14 \u0643\u063a\\\u0645\u0644. \u0643\u0645\u0627 \u064a\u0638\u0647\u0631 \u062c\u062f\u0648\u0644 (1).<\/span><\/p>\n

              -\u0641\u0635\u0644 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0641\u0639\u0627\u0644 \u0648\u0639\u0632\u0644\u0647:<\/span><\/p>\n

              \u062c\u0631\u0649 \u062a\u062d\u0636\u064a\u0631 \u0645\u0639\u0644\u0642 \u0641\u064a \u0643\u0645\u064a\u0629 \u0643\u0627\u0641\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u0645\u062c\u0641\u0641\u0629 RS.au \u0627\u0644\u062a\u064a \u0623\u0638\u0647\u0631\u062a \u0623\u0639\u0644\u0649 \u0641\u0639\u0627\u0644\u064a\u0629 \u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0627\u062a\u062c\u0627\u0647 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632\u060c \u0644\u064a\u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0628\u0639\u062f\u0647\u0627 \u0639\u0644\u0649 \u062e\u0644\u0627\u0635\u0629 \u0625\u064a\u062a\u0631\u064a\u0629 \u0648\u0630\u0644\u0643 \u0628\u0625\u0636\u0627\u0641\u0629 \u0627\u0644\u0625\u064a\u062a\u0631 \u0625\u0644\u0649 \u0627\u0644\u0645\u0639\u0644\u0642 \u0627\u0644\u0645\u0627\u0626\u064a\u060c \u0648\u062b\u0645 \u0641\u0635\u0644 \u0628\u0639\u0636\u0647\u0645\u0627 \u0639\u0646 \u0628\u0639\u0636 \u0628\u0648\u0627\u0633\u0637\u0629 \u0642\u0645\u0639 \u0627\u0644\u0641\u0635\u0644 \u0648\u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0633\u0627\u0626\u0644 \u0633\u0627\u0626\u0644\u060c \u062d\u064a\u062b \u062a\u0645 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a. \u0648\u0628\u0646\u0641\u0633 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u062e\u0644\u0627\u0635\u0629 \u062e\u0644\u0627\u062a\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062e\u0644\u0627\u062a \u0627\u0644\u0625\u064a\u062a\u064a\u0644. \u0648\u0633\u0645\u064a\u062a \u0627\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u0645\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629 \u0628\u0639\u062f \u0627\u0644\u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0628\u0627\u0644\u0625\u064a\u062a\u0631 \u0648\u0628\u0627\u0644\u062e\u0644\u0627\u062a \u0628\u0627\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u0645\u0627\u0626\u064a\u0629. \u0631\u064f\u0634\u0651\u062d\u062a \u0627\u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0648\u062c\u0641\u0651\u0641\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0628\u062e\u0631 \u0627\u0644\u062f\u0648\u0627\u0631. \u062b\u0645 \u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0623\u062c\u0632\u0627\u0621 \u0627\u0644\u062e\u0644\u0627\u0635\u0629 RS.au \u0639\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632\u060c \u062b\u0645 \u062a\u0645 \u062d\u0633\u0627\u0628 \u0642\u064a\u0645 50<\/sub>IC \u0644\u0647\u0627\u060c \u062c\u062f\u0648\u0644 (2). \u062b\u0645 \u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0645\u0633\u062d \u0644\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u062e\u0644\u0627\u062a\u064a\u0629 \u0645\u0646 RS.au \u0648\u0627\u0644\u062a\u064a \u0623\u0638\u0647\u0631\u062a \u0623\u0639\u0644\u0649 \u0641\u0639\u0627\u0644\u064a\u0629 \u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0627\u062a\u062c\u0627\u0647 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0627\u0644\u062a\u062d\u0636\u064a\u0631\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 HPLC-Preparative . \u0623\u0638\u0647\u0631 \u0627\u0644\u0645\u062e\u0637\u0637 \u0627\u0644\u0643\u0631\u0648\u0645\u0627\u062a\u0648\u063a\u0631\u0627\u0641\u064a \u0648\u062c\u0648\u062f \u0642\u0645\u062a\u064a\u0646 \u0623\u0633\u0627\u0633\u064a\u062a\u064a\u0646 \u0639\u0646\u062f 13.5 \u0648 15 \u062f\u0642\u064a\u0642\u0629. \u062a\u0645 \u0639\u0632\u0644 \u0627\u0644\u0645\u0631\u0643\u0628\u064a\u0646 \u062a\u062d\u062a \u0627\u0644\u0642\u0645\u062a\u064a\u0646 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u062a\u064a\u0646. \u062b\u0645 \u0623\u064f\u062c\u0631\u064a\u062a \u062f\u0631\u0627\u0633\u0629 \u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u0631\u0643\u0628\u064a\u0646 \u0627\u0644\u0645\u0639\u0632\u0648\u0644\u064a\u0646 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u062e\u0644\u0627\u062a\u064a\u0629 \u0645\u0646 RS.au \u0639\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0648\u062d\u0633\u0627\u0628 \u0642\u064a\u0645 50<\/sub>IC \u0644\u0647\u0627\u060c \u062c\u062f\u0648\u0644 (3).<\/span><\/p>\n

              \"\"<\/span><\/p>\n

              \"\"<\/span><\/p>\n

              \u062d\u064f\u062f\u0651\u062f\u062a \u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0623\u0648\u0644 \u0627\u0644\u0645\u0639\u0632\u0648\u0644 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u062e\u0644\u0627\u062a\u064a\u0629 RS.au \u0627\u0644\u0630\u064a \u0623\u0638\u0647\u0631 \u0623\u0639\u0644\u0649 \u0641\u0639\u0627\u0644\u064a\u0629 \u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0627\u062a\u062c\u0627\u0647 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0648\u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 \u0627\u0644\u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u0646\u0635\u0641\u064a \u0644\u0647 91=50IC \u0645\u0643\u063a\\\u0645\u0644. \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0643\u062a\u0644\u0629 MS \u0648\u062c\u0647\u0627\u0632 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 FTIR \u0648\u062c\u0647\u0627\u0632 \u0637\u064a\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064aNMR.<\/span><\/p>\n

              – \u062a\u062d\u0644\u064a\u0644 \u0628\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0645\u0639\u0632\u0648\u0644:<\/span><\/p>\n

              ESI-MS <\/strong>m\/z 303 [M+H]+, IR \u03bd [cm-1]: 3407 (-OH), 1663 (-C=O), 1614 (C=C). 1H NMR <\/strong>(400 MHz, DMSO-d6<\/em>, \u03b4 [ppm], J <\/em>[Hz]): \u03b4 12.50 (s, 1H-OH-5), 10.79 (s, 1H-OH-7), 9.60 (s, 1H-OH-3), 9.38 (s, 2H-OH-3\u2019,4\u2019), 7.68 (d, J = 2.2 Hz, 1H-2\u2019), 7.54 (dd, J = 8.5, 2.2 Hz, 1H-6\u2019), 6.88 (d, J = 8.5 Hz, 1H-5\u2019), 6.40 (d, J = 2.0 Hz, 1H-8), 6.18 (d, J = 2.0 Hz, 1H-6). 13C NMR <\/strong>(101 MHz, DMSO-d6<\/em>, \u03b4 [ppm]): \u03b4 175.88 (C, C-4), 163.93 (C, C-7), 160.76 (C, C-9), 156.18 (C, C-5), 147.74 (C, C-2), 146.83 (C, C-4\u2019), 145.09 (C, C-3\u2019), 135.77 (C, C-3), 122.00 (C, C-1\u2019), 120.01 (CH, C-6\u2019), 115.65 (CH, C-2\u2019), 115.11 (CH, C-5\u2019), 103.05 (C, C-10), 98.22 (CH, C-6), 93.39 (CH, C-8).<\/span><\/p>\n

              \u00a0<\/strong><\/span>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629<\/strong> Discussion <\/strong>:<\/strong><\/span><\/p>\n

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(Conforti et al)\u060c <\/span>\u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0645\u0639\u0632\u0648\u0644 \u0639\u0644\u0649 \u0634\u0643\u0644 \u0628\u0648\u062f\u0631\u0629 \u0635\u0641\u0631\u0627\u0621 \u0627\u0644\u0644\u0648\u0646. \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0645\u0639\u0637\u064a\u0627\u062a \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a\u0629 \u0648\u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0644\u0647 \u0628\u0646\u064a\u0629 \u0641\u0644\u0627\u0641\u0648\u0646\u0648\u0626\u064a\u062f\u064a\u0629 (Sambandam et al.) (Hu et al.) 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\u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0632\u0645\u0631\u0629 \u0627\u0644\u0643\u064a\u062a\u0648\u0646\u060c \u0648\u062d\u0632\u0645\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0639\u0646\u062f 1614 cm-1 \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0632\u0645\u0631 C=C \u0627\u0644\u0639\u0637\u0631\u064a\u0629. \u0623\u0638\u0647\u0631 \u0637\u064a\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064a 13<\/sup>C-NMR \u0630\u0631\u0629 \u0643\u0631\u0628\u0648\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u0643\u0628 \u0643\u0645\u0627 \u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 (3). \u0648\u0623\u0638\u0647\u0631 \u0637\u064a\u0641 5DEPT \u0632\u0645\u0631 \u0645\u064a\u062a\u064a\u0646. \u0648 10 \u0630\u0631\u0627\u062a \u0643\u0631\u0628\u0648\u0646 \u0631\u0627\u0628\u0639\u064a\u0629. \u0648\u0623\u0638\u0647\u0631 \u0637\u064a\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u064a 1<\/sup>H-NMR 5 \u0628\u0631\u0648\u062a\u0648\u0646\u0627\u062a \u0639\u0637\u0631\u064a\u0629 \u0643\u0645\u0627 \u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0634\u0643\u0644 (2). \u062a\u0645 \u062a\u0623\u0643\u064a\u062f \u062a\u0648\u0636\u0639 \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u0627\u062a \u0627\u0644\u0639\u0637\u0631\u064a\u0629 \u0639\u0646\u062f \u03b4 7.68 ppm \u0648 \u03b4 7.54 ppm \u0639\u0644\u0649 \u0630\u0631\u0627\u062a \u0627\u0644\u0643\u0631\u0628\u0648\u0646 C2\u2019 \u0648 C6\u2019 \u0628\u0648\u0627\u0633\u0637\u0629 \u0642\u064a\u0645\u0629 \u062b\u0627\u0628\u062a \u0627\u0644\u062a\u0632\u0627\u0648\u062c \u0645\u064a\u062a\u0627 2.2Hz \u0648 \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0641\u064a \u0637\u064a\u0641 HMBC . \u062a\u0645 \u062a\u0623\u0643\u064a\u062f \u062a\u0648\u0636\u0639 \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u0627\u062a \u0627\u0644\u0639\u0637\u0631\u064a\u0629 \u0639\u0646\u062f \u03b4 6.88 ppm \u0648 \u03b4 7.54 ppm \u0639\u0644\u0649 \u0630\u0631\u0627\u062a \u0627\u0644\u0643\u0631\u0628\u0648\u0646 C5\u2019 \u0648 C6\u2019 \u0628\u0648\u0627\u0633\u0637\u0629 7 \u0642\u064a\u0645\u0629 \u062b\u0627\u0628\u062a \u0627\u0644\u062a\u0632\u0627\u0648\u062c 8.5Hz \u0648\u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0641\u064a \u0637\u064a\u0641 COSY . \u0623\u0638\u0647\u0631 \u0643\u0644 \u0645\u0646 \u0637\u064a\u0641 HMBC \u0648\u0637\u064a\u0641 HSQC \u062a\u0631\u0627\u0628\u0637\u0627 \u0628\u064a\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u0627\u062a \u0639\u0646\u062f \u03b4 6.18 ppm \u0648 \u03b4 6.40 ppm \u0648 \u03b4 6.88 ppm \u0648 \u03b4 7.68 ppm \u0648 \u03b4 7.54 ppm \u0645\u0639 \u0630\u0631\u0627\u062a \u0627\u0644\u0643\u0631\u0628\u0648\u0646 \u0639\u0646\u062f \u03b4 98.22 ppm ((C6\u060c \u0648 \u03b4 93.39 ppm (C8)\u060c \u0648\u03b4 115.65 ppm \u00a0(C5′) \u0648 \u03b4 115.11 ppm (\u2019C2) \u0648\u03b4 120.01 ppm \u00a0(\u2019(C6 \u0628\u0627\u0644\u062a\u0631\u062a\u064a\u0628. \u0627\u062d\u062a\u0648\u062a \u0627\u0644\u062d\u0644\u0642\u0629 \u0627\u0644\u0639\u0637\u0631\u064a\u0629 A \u0639\u0644\u0649 \u0630\u0631\u062a\u064a \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646 \u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644 \u0644\u0647\u0627 \u0625\u0634\u0627\u0631\u0627\u062a \u0639\u0637\u0631\u064a\u0629 \u0641\u064a \u0637\u064a\u0641 \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646 \u0639\u0646\u062f \u03b4 12.50 ppm \u0644\u0644\u0645\u0648\u0642\u0639 C5 \u0648\u0639\u0646\u062f \u03b4 10.79 ppm \u0644\u0644\u0645\u0648\u0642\u0639 C7\u060c \u0648\u0627\u062d\u062a\u0648\u062a \u0627\u0644\u062d\u0644\u0642\u0629 \u0627\u0644\u0639\u0637\u0631\u064a\u0629 B \u0639\u0644\u0649 \u0630\u0631\u062a\u064a \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646 \u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644 \u0644\u0647\u0627 \u0625\u0634\u0627\u0631\u0627\u062a \u0639\u0637\u0631\u064a\u0629 \u0641\u064a \u0637\u064a\u0641 \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646 \u0639\u0646\u062f \u03b4 9.38 ppm \u0644\u0644\u0645\u0648\u0642\u0639 `C3 \u0648\u0644\u0644\u0645\u0648\u0642\u0639 `C4. \u0644\u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0631\u0643\u0628 \u0647\u0648 \u0627\u0644\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646 \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u0634\u0643\u0644 (1)\u060c \u0648\u0647\u0648 \u0645\u0631\u0643\u0628 \u0644\u0647 \u0641\u0639\u0627\u0644\u064a\u0629 \u0645\u0639\u0631\u0648\u0641\u0629 \u0633\u0627\u0628\u0642\u0627\u064b \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 (Martinez-Gonzalez et al.) \u0648\u0644\u0643\u0646\u0647 \u064a\u0639\u0632\u0644 \u0644\u0623\u0648\u0644 \u0645\u0631\u0629 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 R.sanctus. <\/span><\/p>\n

              \"\u0634\u0643\u0644
              \u0634\u0643\u0644 (1) \u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0645\u0639\u0632\u0648\u0644 (\u0627\u0644\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646) \u0648\u0627\u0631\u062a\u0628\u0627\u0637 COSY \u0648 HMBC \u0641\u064a \u0637\u064a\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a NMR<\/span><\/strong><\/figcaption><\/figure>\n
              \"\u0634\u0643\u0644
              \u0634\u0643\u0644 (2) \u0637\u064a\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u064a 1HNMR \u0644\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0645\u0639\u0632\u0648\u0644 (\u0627\u0644\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646)<\/span><\/strong><\/figcaption><\/figure>\n
              \"\u0634\u0643\u0644
              \u0634\u0643\u0644 (3) \u0637\u064a\u0641 \u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064aCNMR13 \u0644\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0645\u0639\u0632\u0648\u0644 (\u0627\u0644\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646)<\/span><\/strong><\/figcaption><\/figure>\n

              \u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a<\/strong> :Conclusions <\/strong><\/span><\/p>\n

              \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646 \u0643\u0644 \u0645\u0646 \u0646\u0628\u0627\u062a\u064a \u0627\u0644\u0632\u0639\u0631\u0648\u0631 \u0648\u0627\u0644\u0639\u0644\u064a\u0642 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0633\u0648\u0631\u064a\u0627 \u0643\u0627\u0646 \u0644\u0647\u0645\u0627 \u0641\u0639\u0627\u0644\u064a\u0629 \u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632\u060c \u0644\u0630\u0644\u0643 \u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062e\u0644\u0627\u0635\u0627\u062a\u0647\u0645\u0627 \u0641\u064a \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0648\u0627\u0644\u062d\u062f \u0645\u0646 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0648\u0632\u0646 \u0643\u0628\u062f\u0627\u0626\u0644 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0623\u0633\u0648\u0627\u0642. \u0628\u064a\u0646\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u0630\u064a \u062c\u0645\u0639 \u0641\u064a\u0647 \u0627\u0644\u0646\u0628\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632\u060c \u0648\u0647\u0630\u0627 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0644\u0645 \u064a\u062f\u0631\u0633 \u0633\u0627\u0628\u0642\u0627\u064b\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0623\u0639\u0644\u0649 \u0644\u062e\u0644\u0627\u0635\u0627\u062a \u0627\u0644\u0646\u0628\u0627\u062a\u064a\u0646 \u0627\u0644\u062a\u064a \u062c\u0645\u0639\u062a \u0641\u064a \u0641\u0635\u0644 \u0627\u0644\u062e\u0631\u064a\u0641 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062c\u0645\u0639\u062a \u0641\u064a \u0641\u0635\u0644 \u0627\u0644\u0631\u0628\u064a\u0639. \u0628\u064a\u0646\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646 \u0627\u0644\u0646\u0648\u0639 Rubus sanctus \u0623\u0639\u0637\u0649 \u0623\u0639\u0644\u0649 \u0641\u0639\u0627\u0644\u064a\u0629 \u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u062e\u0631\u0649. \u0643\u0645\u0627 \u062a\u0628\u064a\u0646 \u0623\u0646 \u0627\u0644\u0646\u0648\u0639 Crataegus monogyna \u0644\u0645 \u064a\u062f\u0631\u0633 \u062a\u0623\u062b\u064a\u0631\u0647 \u0633\u0627\u0628\u0642\u0627 \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632\u060c \u0648\u0642\u062f \u0638\u0647\u0631 \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0641\u0639\u0627\u0644\u064a\u0629 \u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0646\u0632\u064a\u0645 \u062d\u064a\u062b \u0623\u0639\u0637\u0649 \u0642\u064a\u0645 50<\/sub>IC \u062a\u0631\u0627\u0648\u062d\u062a \u0628\u064a\u0646 93 \u0648 132 \u0645\u0643\u063a\\\u0645\u0644. \u0648\u0642\u062f \u062a\u0628\u064a\u0646 \u0623\u0646 \u0628\u064a\u0646\u0629 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0630\u064a \u0639\u0632\u0644 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 Rubus sanctus \u0648\u0627\u0644\u0630\u064a \u0623\u0638\u0647\u0631 \u0623\u0639\u0644\u0649 \u0641\u0639\u0627\u0644\u064a\u0629 \u062a\u062b\u0628\u064a\u0637\u064a\u0629 \u0639\u0644\u0649 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0627\u0644\u0643\u0648\u064a\u0631\u0633\u064a\u062a\u064a\u0646 \u0627\u0644\u0630\u064a \u064a\u0646\u062a\u0645\u064a \u0625\u0644\u0649 \u0641\u0626\u0629 \u0627\u0644\u0641\u0644\u0627\u0641\u0648\u0646\u0648\u0626\u064a\u062f\u0627\u062a\u060c \u0648\u0647\u0648 \u0645\u0631\u0643\u0628 \u0645\u0639\u0631\u0648\u0641 \u0628\u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0644\u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0644\u064a\u0628\u0627\u0632 \u0648\u0644\u0643\u0646\u0647 \u064a\u0639\u0632\u0644 \u0644\u0623\u0648\u0644 \u0645\u0631\u0629 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 Rubus sanctus.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

              \u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062a\u0631\u0627\u0643\u0645 \u0632\u0627\u0626\u062f \u0623\u0648 \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a \u0644\u0644\u062f\u0633\u0645 \u0641\u064a \u0627\u0644\u062c\u0633\u0645\u060c \u064a\u0646\u062a\u062c \u0639\u0646 \u0639\u062f\u0645 \u0627\u0644\u062a\u0648\u0627\u0632\u0646 \u0628\u064a\u0646 \u0643\u0645\u064a\u0629 \u0627\u0644\u0637\u0639\u0627\u0645 \u0627\u0644\u0645\u062a\u0646\u0627\u0648\u0644\u0629\u060c…
              \u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":514,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-183","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-133","volume-8"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=183"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/183\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/514"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}