{"id":1958,"date":"2025-04-26T13:55:11","date_gmt":"2025-04-26T13:55:11","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=1958"},"modified":"2025-04-26T13:55:11","modified_gmt":"2025-04-26T13:55:11","slug":"%d8%a7%d9%84%d8%b9%d9%88%d8%a7%d9%85%d9%84-%d8%a7%d9%84%d9%85%d9%86%d8%a8%d8%a6%d8%a9-%d8%a8%d9%85%d8%ad%d8%b5%d9%91%d9%84%d8%a7%d8%aa-%d8%a7%d9%84%d9%85%d8%b1%d8%b6-%d9%84%d8%af%d9%89-%d8%ac%d9%85","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=1958","title":{"rendered":"\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0646\u0628\u0626\u0629 \u0628\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0642\u0648\u0644\u0648\u0646 \u0633\u0648\u0631\u064a\u064a\u0646: \u062f\u0631\u0627\u0633\u0629 \u062d\u0634\u062f\u064a\u0629"},"content":{"rendered":"<p><strong>\u0627\u0644\u0645\u0642\u062f\u0645\u0629<\/strong><strong> Introductio<\/strong><strong>n <\/strong><\/p>\n<p>\u0633\u0631\u0637\u0627\u0646\u064f \u0627\u0644\u0642\u0648\u0644\u0648\u0646\u0650 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645\u0650 \u062f\u0627\u0621\u064c \u062e\u0628\u064a\u062b\u064c \u0645\u062a\u063a\u0627\u064a\u0631\u060c \u064a\u0628\u062f\u0623 \u0628\u0646\u0645\u0648\u0651\u064d \u063a\u064a\u0631 \u0645\u0636\u0628\u0648\u0637\u064d \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0634\u0643\u0651\u0650\u0644 \u0628\u062f\u0621\u0627\u064b \u0646\u0627\u0645\u064a\u0629\u064b \u0635\u063a\u064a\u0631\u0629\u064b \u062a\u062f\u0639\u0649 \u0633\u0644\u064a\u0644\u0629 polyp\u060c \u062a\u062a\u0637\u0648\u0631 \u0639\u0627\u062f\u0629\u064b \u0644\u062a\u0634\u0643\u0644 \u0648\u0631\u0645\u0627\u064b \u063a\u062f\u064a\u0651\u0627\u064b \u062d\u0645\u064a\u062f\u0627\u064b adenoma. \u0645\u0639 \u062a\u0631\u0627\u0643\u0645\u0650 \u0627\u0644\u0637\u0641\u0631\u0627\u062a\u0650 \u064a\u062a\u062d\u0648\u0651\u0644 \u0627\u0644\u0648\u0631\u0645\u064f \u0627\u0644\u063a\u062f\u064a\u0651\u064f \u0627\u0644\u062d\u0645\u064a\u062f\u064f \u0625\u0644\u0649 \u0633\u0631\u0637\u0627\u0646\u0629 carcinoma (1,2) \u0648\u062a\u062a\u0637\u0644\u0628 \u0639\u0645\u0644\u064a\u0629\u064f \u0627\u0644\u0627\u0633\u062a\u062d\u0627\u0644\u0629\u060c \u0648\u0631\u0645 \u063a\u062f\u064a \u062d\u0645\u064a\u062f- \u0633\u0631\u0637\u0627\u0646\u0629\u060c \u0645\u062f\u0629\u064b \u0642\u062f \u062a\u0633\u062a\u063a\u0631\u0642 10-15 \u0639\u0627\u0645\u0627\u064b \u062a\u062a\u0631\u0627\u0643\u0645\u064f \u062e\u0644\u0627\u0644\u0647\u0627 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u063a\u064a\u0651\u0631 \u0627\u0644\u0639\u0645\u0644\u064a\u0651\u0627\u062a\u0650 \u0627\u0644\u0645\u0641\u062a\u0627\u062d\u064a\u0629\u0651\u064e \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0645\u062b\u0644 \u0627\u0644\u0646\u0645\u0648 \u0648\u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u0648\u0627\u0644\u0639\u064a\u0648\u0634\u064a\u0651\u0629. 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\u0628\u0639\u0648\u0627\u0645\u0644\u064e \u0639\u062f\u0651\u0629\u064d (\u0645\u062b\u0644 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0648\u062f\u0631\u062c\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632 \u0648\u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a \u0644\u0644\u0648\u0631\u0645 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062d\u064e\u062f\u064e\u062b\u064a\u0627\u062a \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0627\u0644\u062e\u062b\u0631\u064a\u0629 \u0648\u0627\u0644\u0646\u0632\u0641\u064a\u0629 \u0648\u0648\u062c\u0648\u062f \u0627\u0644\u062a\u0627\u0631\u064a\u062e \u0627\u0644\u0639\u0627\u0626\u0644\u064a \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0623\u0648 \u063a\u064a\u0627\u0628\u0647).<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Materials and Methods<\/strong><\/p>\n<p>\u0635\u064f\u0645\u0651\u0645\u0650\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u062a\u0643\u0648\u0646 \u062d\u0634\u062f\u064a\u0629\u064b \u0627\u0633\u062a\u0628\u0627\u0642\u064a\u0651\u0629\u060c \u062a\u0633\u062a\u0647\u062f\u0641 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0642\u0648\u0644\u0648\u0646\u064d \u0633\u0648\u0631\u064a\u064a\u0646 \u0645\u0631\u0627\u062c\u0639\u064a\u0646 \u0644\u0648\u062d\u062f\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0647\u0636\u0645\u064a\u0629 \u0641\u064a \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0628\u064a\u0631\u0648\u0646\u064a \u0627\u0644\u062c\u0627\u0645\u0639\u064a \u0644\u062a\u0644\u0642\u064a \u0627\u0644\u0639\u0644\u0627\u062c. \u0623\u062c\u0631\u064a\u0646\u0627 \u0645\u0642\u0627\u0628\u0644\u0627\u062a\u064d \u0645\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0629 \u0645\u0646 \u062d\u0632\u064a\u0631\u0627\u0646 \u0639\u0627\u0645 2022 \u0648\u062d\u062a\u0649 \u0634\u0628\u0627\u0637 \u0639\u0627\u0645 2023\u061b \u0628\u063a\u064a\u0629 \u0645\u0644\u0621 \u0627\u0644\u0627\u0633\u062a\u0628\u0627\u0646\u0629 \u0627\u0644\u0647\u0627\u062f\u0641\u0629 \u0644\u062c\u0645\u0639 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0648\u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629\u060c \u0648\u0627\u0633\u062a\u064f\u0643\u0645\u0650\u0644\u064e\u062a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0628\u0627\u0644\u0639\u0648\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u0633\u062c\u0644\u0651\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0651\u0629 \u0644\u0644\u0645\u0631\u0636\u0649. \u0634\u0645\u0644\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 inclusion criteria\u061b \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0642\u0648\u0644\u0648\u0646 \u0645\u0646 \u0643\u0644\u0627 \u0627\u0644\u062c\u0646\u0633\u064a\u0646\u060c \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 30-70 \u0639\u0627\u0645\u0627\u064b\u060c \u0641\u064a \u062d\u064a\u0646 \u062a\u0636\u0645\u0651\u0646\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f exclusion criteria\u061b \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062d\u0648\u0627\u0645\u0644. \u062a\u0627\u0628\u0639\u0646\u0627 \u0627\u0644\u0645\u0631\u0636\u0649 \u062f\u0648\u0631\u064a\u0651\u064b\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0632\u064a\u0627\u0631\u0629 \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u0649 \u0648\u0645\u0631\u0627\u062c\u0639\u0629 \u0633\u062c\u0644\u0627\u062a\u0647\u0645 \u0627\u0644\u0637\u0628\u064a\u0629 \u0648\u0627\u0644\u0627\u062a\u0635\u0627\u0644 \u0628\u0647\u0645 \u0647\u0627\u062a\u0641\u064a\u0651\u064b\u0627 \u0628\u0634\u0643\u0644\u064d \u062f\u0648\u0631\u064a\u0651\u064d \u0645\u062f\u0629\u064b \u0632\u0645\u0646\u064a\u0629 \u0642\u062f\u0631\u0647\u0627 20 \u0634\u0647\u0631\u064b\u0627.<\/p>\n<p><strong>\u0645\u0639\u0627\u064a\u064a\u0631 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629<\/strong><\/p>\n<p>\u0635\u064f\u0646\u0651\u0650\u0641\u062a \u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0645\u0646 \u0642\u0650\u0628\u064e\u0644 \u0627\u0644\u0623\u0637\u0628\u0627\u0621 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0646 \u0641\u064a \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0628\u064a\u0631\u0648\u0646\u064a\u0651 \u0627\u0644\u062c\u0627\u0645\u0639\u064a \u062d\u062a\u0649 \u0622\u062e\u0631 \u0646\u0642\u0637\u0629 \u0645\u062a\u0627\u0628\u0639\u0629\u060c \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 &#8220;\u0645\u0639\u0627\u064a\u064a\u0631 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0635\u0644\u0628\u0629 Response Evaluation Criteria In Solid\u00a0Tumors (RECIST)&#8221;. (10) \u062d\u064a\u062b \u062a\u064f\u0635\u0646\u0651\u0641 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u0644\u062a\u062f\u0627\u0628\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0648\u0641\u0642\u064b\u0627 \u0644\u0645\u0627 \u062c\u0631\u0649 \u062a\u0628\u064a\u0627\u0646\u0647 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u06441. \u0639\u064f\u0631\u0651\u0650\u0641\u062a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 overall survival (OS) \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0645\u0639\u0647\u062f \u0627\u0644\u0648\u0637\u0646\u064a \u0644\u0644\u0633\u0631\u0637\u0627\u0646 National Cancer Institute (NCI) \u0628\u0623\u0646\u0647\u0627 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0645\u0646\u0630 \u062a\u0627\u0631\u064a\u062e \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0648\u062d\u062a\u0649 \u0627\u0644\u0648\u0641\u0627\u0629 \u0623\u0648 \u0627\u0646\u062a\u0647\u0627\u0621 \u0627\u0644\u0645\u062a\u0627\u0628\u0639\u0629. (12). \u0648\u0639\u064f\u0631\u0651\u0641 \u0627\u0644\u0646\u0643\u0633 \u0648\u0641\u0642\u064b\u0627 \u0644\u0644\u062c\u0645\u0639\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 American Cancer Society \u0628\u0623\u0646\u0647 \u0639\u0648\u062f\u0629 \u0623\u064a\u0651\u0629 \u062d\u062f\u062b\u064a\u0651\u0629 \u0648\u0631\u0645\u064a\u0629 \u0628\u0639\u062f \u062a\u062f\u0628\u064a\u0631\u064d \u0639\u0644\u0627\u062c\u064a\u0651\u064d \u0634\u0627\u0641\u064d. (11). \u0643\u0630\u0644\u0643 \u0635\u064f\u0646\u0651\u0641\u062a \u0627\u0644\u062e\u0628\u0627\u062b\u0629 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a \u0644\u0644\u062e\u0628\u0627\u062b\u0629 \u0625\u0644\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0645\u0646 (\u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0635\u0627\u0639\u062f \u0648\/\u0623\u0648 \u0627\u0644\u0645\u0633\u062a\u0639\u0631\u0636)\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0633\u0631 (\u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0646\u0627\u0632\u0644 \u0648\/\u0623\u0648 \u0627\u0644\u0633\u064a\u0646\u064a).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1959 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/1-1-300x292.png\" alt=\"\" width=\"415\" height=\"403\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/1-1-300x292.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/1-1.png 319w\" sizes=\"auto, (max-width: 415px) 100vw, 415px\" \/><\/p>\n<p><strong>\u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u064f \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629<\/strong>:<\/p>\n<p>\u062d\u064f\u0644\u0651\u0644\u062a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064b\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0645\u062c\u064a\u0629 GraphPad Prism 10.1.0\u060c \u0648\u064f\u0635\u0651\u0650\u0641\u062a \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u0627\u062a \u0627\u0644\u0641\u0626\u0648\u064a\u0629 \u0628\u0627\u0644\u062a\u0648\u0627\u062a\u0631 n \u0648\u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629%\u060c \u0648\u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 Chi-square test \u0623\u0648 Fisher\u2019s exact test \u0644\u0625\u064a\u062c\u0627\u062f \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u062a\u0644\u0643 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a\u060c \u0648\u0627\u0633\u062a\u062e\u062f\u0645\u0646\u0627 \u0645\u0646\u062d\u0646\u064a\u0627\u062a Kaplan-Meier \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 overall survival \u0648\u0637\u064f\u0628\u0651\u0650\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 Log Rank \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0645\u0646\u062d\u0646\u064a\u0627\u062a \u0627\u0644\u0628\u0642\u064a\u0627 \u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629. \u062a\u0645 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0629 \u0627\u0644\u0645\u0648\u0632\u0651\u0639\u0629 \u062a\u0648\u0632\u0639\u064b\u0627 \u0637\u0628\u064a\u0639\u064a\u0651\u064b\u0627 \u0628\u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a standard deviation (SD).<\/p>\n<p><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c Results<\/strong><\/p>\n<p><strong>\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0651\u0629:<\/strong><\/p>\n<p>\u0636\u0645\u062a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 82 \u0645\u0631\u064a\u0636 \u0633\u0631\u0637\u0627\u0646 \u0642\u0648\u0644\u0648\u0646\u060c \u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 31 \u064870 \u0639\u0627\u0645\u0627\u064b\u060c \u0648\u0628\u0644\u063a \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a\u0651 \u0644\u0623\u0639\u0645\u0627\u0631 \u0643\u0627\u0645\u0644 \u0627\u0644\u062c\u0645\u0647\u0631\u0629 (\u00b1SD) 54 \u0639\u0627\u0645\u0627 (\u00b110.3). \u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642 \u064a\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0628\u064a\u0646 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u00b1SD \u0644\u0623\u0639\u0645\u0627\u0631 \u0627\u0644\u0630\u0643\u0648\u0631 (1\u00b1 53.9) \u0648\u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u00b1SD \u0644\u0623\u0639\u0645\u0627\u0631 \u0627\u0644\u0625\u0646\u0627\u062b (54.92.3\u00b1 ) \u062d\u064a\u062b <em>p=<\/em>0.984. \u0634\u064f\u062e\u0651\u0635 31 \u0645\u0631\u064a\u0636\u0627\u064b (37.8%) \u0628\u0639\u0645\u0631 \u226450 \u0639\u0627\u0645\u0627\u064b\u060c \u0648\u0643\u0627\u0646 10 \u0645\u0631\u0636\u0649 \u0645\u0646 \u0647\u0624\u0644\u0627\u0621 (\u0623\u064a 12.2% \u0645\u0646 \u0645\u062c\u0645\u0644 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629) \u0628\u0623\u0639\u0645\u0627\u0631&lt;40 \u0639\u0627\u0645\u0627\u064b. \u0628\u0644\u063a \u0639\u062f\u062f \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646 30 \u0645\u0631\u064a\u0636\u0627\u064b (36.6%)\u060c \u0648\u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u0630\u0643\u0648\u0631 \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646 \u0636\u0639\u0641 \u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0646\u0627\u062b \u0627\u0644\u0645\u062f\u062e\u0646\u0627\u062a (24.4% \u0645\u0642\u0627\u0628\u0644 12.2%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628) \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0629\u064d \u0644\u0644\u0641\u0627\u0631\u0642 (<em>p<\/em>= 0.114). \u0623\u0628\u0644\u064e\u063a\u064e 59 \u0645\u0631\u064a\u0636\u0627\u064b (72%) \u0639\u0646 \u0648\u062c\u0648\u062f \u0642\u0635\u0629\u064d \u0639\u0627\u0626\u0644\u064a\u0651\u0629\u064d \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0628\u0623\u0646\u0648\u0627\u0639\u0647 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u062f\u0649 \u0623\u0642\u0627\u0631\u0628 \u0627\u0644\u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u062a\u0648\u0632\u0639\u062a \u0639\u0644\u0649 \u0627\u0644\u0646\u062d\u0648 \u0627\u0644\u0645\u064f\u0628\u064a\u0651\u0646 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 2.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1960 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/2-1-122x300.png\" alt=\"\" width=\"260\" height=\"639\" \/><\/p>\n<p><strong>\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062e\u0628\u0627\u062b\u0629:<\/strong><\/p>\n<p>\u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0633\u0631 \u0623\u0639\u0644\u0649\u00a0\u00a0\u00a0\u00a0\u00a0 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0645\u0646 (58.5% \u0645\u0642\u0627\u0628\u0644 41.5%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628). \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0641\u0642\u064b\u0627 \u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 stage \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0639\u0644\u0649 \u0627\u0644\u0646\u062d\u0648 \u0627\u0644\u062a\u0627\u0644\u064a: \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 (I) \u0645\u0631\u064a\u0636\u0627\u0646 (2.4%)\u060c \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (II) 23 \u0645\u0631\u064a\u0636\u0627\u064b (28%)\u060c \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 (III) 20 \u0645\u0631\u064a\u0636\u0627\u064b (24%) \u0648\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0631\u0627\u0628\u0639\u0629 (IV) 36 \u0645\u0631\u064a\u0636\u0627\u064b (44%). \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0643\u0628\u0631 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0623\u0648\u0631\u0627\u0645 \u0645\u062a\u0648\u0633\u0637\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632 \u064a\u0644\u064a\u0647\u0627 \u0627\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0636\u0639\u064a\u0641\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632\u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0642\u0644 \u0644\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u062c\u064a\u062f\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632 (61% \u064830% \u06489%).<\/p>\n<p>\u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628. \u062e\u0636\u0639 70 \u0645\u0631\u064a\u0636\u0627\u064b (85%) \u0644\u0627\u0633\u062a\u0626\u0635\u0627\u0644\u064d \u062c\u0631\u0627\u062d\u064a\u0651\u060c \u0648\u062a\u0644\u0642\u0649 \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0631\u0636\u0649 (98.7%) \u0639\u0644\u0627\u062c\u0627\u064b \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0627\u064b\u060c \u0648\u062e\u0636\u0639 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0646\u0635\u0641 \u0627\u0644\u0645\u0631\u0636\u0649 (53.7%) \u0644\u0639\u0644\u0627\u062c\u064d \u0645\u0646\u0627\u0639\u064a\u0651\u060c \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u062e\u0636\u0639 3 \u0645\u0631\u0636\u0649 \u0641\u0642\u0637 (3.7%) \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0634\u0639\u0627\u0639\u064a. \u062d\u062f\u062b \u0627\u0644\u0646\u0643\u0633 \u0644\u062f\u0649 26 \u0645\u0631\u064a\u0636\u0627\u064b (31.7%). (\u0627\u0644\u062c\u062f\u0648\u0644 3).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1961 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/3-1-141x300.png\" alt=\"\" width=\"256\" height=\"545\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/3-1-141x300.png 141w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/3-1.png 248w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0639 \u0627\u0644\u0646\u0643\u0633:<\/strong><\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a \u0644\u0644\u0648\u0631\u0645 \u0645\u0639 \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0643\u0633<\/strong><\/p>\n<p>\u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u0646\u0627\u0643\u0633\u064a\u0646 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0633\u0631 54.5% (n= 12) \u0623\u0639\u0644\u0649 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0623\u0642\u0631\u0627\u0646\u0647\u0645 \u0627\u0644\u0645\u064f\u0634\u062e\u0651\u0635\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0645\u0646 38% (n= 8)\u060c \u0644\u0643\u0646 \u0627\u0641\u062a\u0642\u0631 \u0647\u0630\u0627 \u0627\u0644\u0641\u0627\u0631\u0642 \u0644\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 (<em>p<\/em>= 0.36).<\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0642\u0635\u0651\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0645\u0639 \u0627\u0644\u0646\u0643\u0633<\/strong><\/p>\n<p>\u0644\u062f\u0649 \u062a\u0635\u0646\u064a\u0641 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0627\u0644\u0642\u0635\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0628\u0623\u0646\u0648\u0627\u0639\u0647 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0623\u0648 \u063a\u064a\u0627\u0628\u0647\u0627. \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0643\u0633 \u0623\u0639\u0644\u0649 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0645\u0644\u0643\u0648\u0646 \u0642\u0635\u0651\u0629 \u0639\u0627\u0626\u0644\u064a\u0651\u0629\u064b \u0644\u0623\u064a\u0651\u0629 \u062e\u0628\u0627\u062b\u0629\u064d \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (33.9% \u0645\u0642\u0627\u0628\u0644 26%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628)\u060c \u063a\u064a\u0631 \u0623\u0646\u0651\u064e \u0627\u0644\u0641\u0627\u0631\u0642\u064e \u0644\u0645 \u064a\u0643\u0646 \u0630\u0627 \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 (<em>p<\/em>= 0.140). \u0644\u062f\u0649 \u062a\u062e\u0635\u064a\u0635 \u0627\u0644\u0642\u0635\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0641\u064a \u0623\u0642\u0627\u0631\u0628 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u060c \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0646\u0627\u0643\u0633\u064a\u0646 \u0645\u0645\u0651\u0646 \u064a\u0645\u0644\u0643\u0648\u0646 \u0642\u0635\u0651\u0629 \u0639\u0627\u0626\u0644\u064a\u0629 \u0623\u0639\u0644\u0649 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u064a\u0633 \u0644\u062f\u064a\u0647\u0645 \u0623\u0642\u0627\u0631\u0628 \u0645\u0646 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0635\u0627\u0628\u064a\u0646\u064e \u0628\u0623\u064a\u0651\u0629 \u062e\u0628\u0627\u062b\u0629 (39.5% \u0645\u0642\u0627\u0628\u0644 23%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628)\u060c \u0648\u0644\u0643\u0646 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642\u064d \u0630\u064a \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 (<em>p<\/em>= 0.154).<\/p>\n<p>\u0644\u062f\u0649 \u062a\u062d\u0631\u0651\u0650\u064a\u0646\u0627 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0642\u0635\u0651\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0651\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062e\u0635\u0648\u0635 \u0648\u0646\u0633\u0628\u0629 \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0643\u0633\u060c \u062a\u0628\u064a\u0651\u0646 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u0641\u064a \u0646\u0633\u0628\u0629 \u0627\u0644\u0646\u0643\u0633 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0648\u0647\u064a 34% \u0645\u0642\u0627\u0628\u0644 30% \u0641\u064a \u062d\u0627\u0644\u0629 \u0648\u062c\u0648\u062f \u0642\u0635\u0651\u0629 \u0639\u0627\u0626\u0644\u064a\u0651\u064e\u0629 \u0623\u0648 \u063a\u064a\u0627\u0628\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628\u060c \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629\u064d \u0644\u0644\u0641\u0627\u0631\u0642 (<em>p<\/em>= 0.799). \u0648\u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0643\u0633 \u0634\u0628\u0647 \u0645\u062a\u0637\u0627\u0628\u0642\u0629\u061b 33% \u064831% \u0641\u064a \u062d\u0627\u0644\u062a\u064e\u064a \u0648\u062c\u0648\u062f \u0627\u0644\u0642\u0635\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0644\u062f\u0649 \u0623\u0642\u0627\u0631\u0628 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u063a\u064a\u0627\u0628\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628 (<em>p<\/em>&gt; 0.999).<\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0633\u0631\u0639\u0629 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0628\u0639\u062f \u0628\u062f\u0621 \u0638\u0647\u0648\u0631 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0645\u0639 \u0627\u0644\u0646\u0643\u0633<\/strong><\/p>\n<p>\u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0646\u0627\u0643\u0633\u064a\u0646 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0634\u064f\u062e\u0651\u0650\u0635\u0648\u0627 \u062e\u0644\u0627\u0644 \u0641\u062a\u0631\u0629\u064d \u0623\u0642\u0635\u0631 \u0645\u0646 \u0623\u0631\u0628\u0639\u0629 \u0623\u0634\u0647\u0631 \u0645\u0646 \u0628\u062f\u0621 \u0638\u0647\u0648\u0631 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 34.6% \u0641\u064a \u062d\u064a\u0646 \u0642\u0627\u0631\u0628\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0636\u0639\u0641 (62.5%) \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0634\u062e\u0651\u0635\u0648\u0627 \u0639\u0642\u0628 \u0645\u0631\u0648\u0631 \u0641\u062a\u0631\u0629\u064d \u0623\u0637\u0648\u0644 \u0639\u0644\u0649 \u0628\u062f\u0621 \u0627\u0644\u0623\u0639\u0631\u0627\u0636\u060c \u063a\u064a\u0631 \u0623\u0646\u0651\u064e \u0627\u0644\u0641\u0627\u0631\u0642 \u0643\u0627\u0646 \u062f\u0648\u0646 \u0642\u064a\u0645\u0629 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 (<em>p<\/em>= 0.113).<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0645\u062a\u062b\u0627\u0628\u062a\u062a\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0639 \u0627\u0644\u0645\u0648\u0627\u062a\u0629:<\/strong><\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0645\u0639 \u0627\u0644\u0645\u0648\u0627\u062a\u0629<\/strong><\/p>\n<p>\u0635\u064f\u0646\u0651\u0641 \u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0625\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635\u060c \u062d\u064a\u062b \u0636\u0645\u0651\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0634\u062e\u0651\u0650\u0635\u0648\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 I \u0648II\u060c \u0641\u064a \u062d\u064a\u0646 \u0634\u0645\u0644\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0634\u062e\u0651\u0635\u0648\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 III \u0648IV.<\/p>\n<p>\u062a\u0628\u064a\u0651\u0646 \u0623\u0646\u0651 \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0648\u0627\u062a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 I \u0648II \u0643\u0627\u0646\u062a \u0646\u062d\u0648 12% (n= 3)\u060c \u0641\u064a \u062d\u064a\u0646 \u0628\u0644\u063a\u062a \u0647\u0630\u0647 \u0627\u0644\u0646\u0633\u0628\u0629 \u0642\u0631\u0627\u0628\u0629 \u0627\u0644\u062e\u0645\u0633\u0629 \u0623\u0636\u0639\u0627\u0641 59% (n= 35) \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 III \u0648IV\u060c \u0628\u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651\u064d \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064b\u0627 (<em>p<\/em>= 0.001). \u0627\u062d\u062a\u0641\u0638 \u0627\u0644\u0641\u0627\u0631\u0642 \u0628\u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0644\u062f\u0649 \u062a\u0642\u0633\u064a\u0645 \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646\u061b \u0636\u0645\u0651\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u0627\u0642\u062a\u0635\u0631\u062a \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u0634\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 IV\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u0648\u0627\u062a\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629 35% \u064863%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628 (<em>p<\/em>= 0.021). \u0648\u0643\u0627\u0646 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 IV \u0645\u0646\u0628\u0626\u0627\u064b \u0628\u0632\u064a\u0627\u062f\u0629 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u0648\u0627\u062a\u0629 \u0628\u0645\u0642\u062f\u0627\u0631 \u062b\u0644\u0627\u062b\u0629 \u0623\u0636\u0639\u0627\u0641 (OR=2.97, 95% CI [1.2, 7.3], <em>p=<\/em>0.01).<\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u062f\u0631\u062c\u0629 \u062a\u0645\u0627\u064a\u0632 \u0627\u0644\u0648\u0631\u0645 \u0645\u0639 \u0627\u0644\u0645\u0648\u0627\u062a\u0629<\/strong><\/p>\n<p>\u0628\u0644\u063a\u062a \u0627\u0644\u0645\u0648\u0627\u062a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0645\u062a\u0648\u0633\u0637\u0629 \u0625\u0644\u0649 \u062c\u064a\u062f\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632 41% \u0645\u0642\u0627\u0628\u0644 \u0646\u0633\u0628\u0629 \u0623\u0639\u0644\u0649 \u0648\u0635\u0644\u062a \u0625\u0644\u0649 62% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0636\u0639\u064a\u0641\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632\u060c \u0644\u0643\u0646 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629\u064d \u0644\u0644\u0641\u0627\u0631\u0642 (<em>p<\/em>= 0.123).<\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062d\u062f\u062b\u064a\u0627\u062a \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0627\u0644\u062e\u062b\u0631\u064a\u0629 \u0648\u0627\u0644\u0646\u0632\u0641\u064a\u0629 \u0645\u0639 \u0627\u0644\u0645\u0648\u0627\u062a\u0629<\/strong><\/p>\n<p>\u0642\u0627\u0631\u0628\u062a \u0627\u0644\u0645\u0648\u0627\u062a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u0646\u0648\u0627 \u0645\u0646 \u062d\u062f\u062b\u064a\u0627\u062a \u0648\u0639\u0627\u0626\u064a\u0629 \u062e\u062b\u0631\u064a\u0629 \u0623\u0648 \u0646\u0632\u0641\u064a\u0629 \u0627\u0644\u0636\u0639\u0641 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0645 \u064a\u0637\u0648\u0651\u0631\u0648\u0627 \u062a\u0644\u0643 \u0627\u0644\u062d\u062f\u062b\u064a\u0627\u062a (80% \u0645\u0642\u0627\u0628\u0644 41%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628) \u0628\u0641\u0627\u0631\u0642\u064d \u0645\u0639\u062a\u062f\u0651\u064d \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b p= 0.009) ( \u0627\u0644\u0634\u0643\u06441. \u0643\u0630\u0644\u0643 \u0628\u064a\u0651\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0651\u0629 \u0623\u0639\u0644\u0649 \u0644\u0644\u0645\u0648\u0627\u062a\u0629 \u0628\u0645\u0642\u062f\u0627\u0631 \u064a\u0642\u0627\u0631\u0628 \u0627\u0644\u0633\u062a\u0651\u0629 \u0623\u0636\u0639\u0627\u0641 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u0646\u0648\u0627 \u0645\u0646 \u062d\u062f\u062b\u064a\u0651\u0627\u062a \u0648\u0639\u0627\u0626\u064a\u0629 \u062e\u062b\u0631\u064a\u0629 \u0623\u0648 \u0646\u0632\u0641\u064a\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0646\u0638\u0631\u0627\u0626\u0647\u0645 \u0627\u0644\u0630\u064a\u0646 \u0644\u0645 \u064a\u0633\u062c\u0651\u0644\u0648\u0627 \u062d\u062f\u062b\u064a\u0627\u062a \u0645\u0634\u0627\u0628\u0647\u0629 (OR= 5.92, 95% CI [1.5, 22.9], p= 0.01)<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1962 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/4-1-300x157.png\" alt=\"\" width=\"558\" height=\"292\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/4-1-300x157.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/4-1.png 633w\" sizes=\"auto, (max-width: 558px) 100vw, 558px\" \/><\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0639 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629:<\/strong><\/p>\n<p>\u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 (OS) \u0644\u0645\u062c\u0645\u0644 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 38 \u0634\u0647\u0631\u064b\u0627. \u062a\u062d\u0631\u064a\u0646\u0627 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0641\u064a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 overall survival (OS) \u00a0\u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n<p><strong>\u062a\u0623\u062b\u064a\u0631 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0641\u064a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629<\/strong><\/p>\n<p>\u0641\u0627\u0642 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u0634\u064e\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 I \u0648 II\u0627\u0644\u0636\u0639\u0641 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 III \u0648 IV(70 \u0634\u0647\u0631\u0627\u064b \u0623\u064a \u0646\u062d\u0648 \u0633\u062a\u0629 \u0623\u0639\u0648\u0627\u0645 \u0645\u0642\u0627\u0628\u0644 32 \u0634\u0647\u0631\u064b\u0627 \u0623\u064a \u0623\u0642\u0644 \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0639\u0648\u0627\u0645\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628)\u060c \u0628\u0641\u0627\u0631\u0642\u064d \u0645\u0639\u062a\u062f\u0651\u064d \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (<em>p<\/em>=0.001). \u0644\u062f\u0649 \u062a\u062e\u0635\u064a\u0635 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u0634\u064e\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629IV \u060c \u0641\u0642\u062f \u062a\u0628\u064a\u0651\u0646 \u0623\u0646 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0651\u0629 \u0639\u0627\u0645\u0627\u0646 \u0648\u0646\u0635\u0641 \u0645\u0642\u0627\u0628\u0644 \u0623\u0631\u0628\u0639\u0629 \u0623\u0639\u0648\u0627\u0645 \u0648\u0646\u0635\u0641 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u060c \u0628\u0641\u0627\u0631\u0642\u064d \u0645\u0639\u062a\u062f\u0651\u064d \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (<em>p<\/em>= 0.001). \u00a0\u0627\u0644\u0634\u0643\u0644 2.<\/p>\n<p><strong>\u062a\u0623\u062b\u064a\u0631 \u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645 \u0641\u064a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629<\/strong><\/p>\n<p>\u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0645\u062a\u0648\u0633\u0637\u0629 \u0625\u0644\u0649 \u062c\u064a\u0651\u062f\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632 40 \u0634\u0647\u0631\u064b\u0627 \u0645\u0642\u0627\u0628\u0644 32 \u0634\u0647\u0631\u0627\u064b \u0644\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0636\u0639\u064a\u0641\u0629 \u0627\u0644\u062a\u0645\u0627\u064a\u0632\u060c \u0648\u0644\u0643\u0646 \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629\u064d \u0644\u0644\u0641\u0627\u0631\u0642 (p= 0.23).<\/p>\n<p><strong>\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062d\u062f\u062b\u064a\u0627\u062a \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u062e\u062b\u0631\u064a\u0629 \u0648\u0627\u0644\u0646\u0632\u0641\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629<\/strong><\/p>\n<p>\u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u0646\u0648\u0627 \u0645\u0646 \u062d\u062f\u062b\u064a\u0627\u062a \u062e\u062b\u0631\u064a\u0629 \u0623\u0648 \u0646\u0632\u0641\u064a\u0629 32 \u0634\u0647\u0631\u064b\u0627 \u0645\u0642\u0627\u0628\u0644 50 \u0634\u0647\u0631\u064b\u0627 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0645 \u064a\u0633\u062c\u0651\u0644\u0648\u0627 \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u062d\u062f\u062b\u064a\u0627\u062a\u060c \u0623\u064a \u0628\u0641\u0627\u0631\u0642 \u0639\u0627\u0645 \u0648\u0646\u0635\u0641 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646\u060c \u0648\u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 (p= 0.039). \u0627\u0644\u0634\u0643\u0644 2.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1963 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/5-1-300x162.png\" alt=\"\" width=\"588\" height=\"318\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/5-1-300x162.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/5-1.png 643w\" sizes=\"auto, (max-width: 588px) 100vw, 588px\" \/><\/p>\n<p><strong>\u062a\u0623\u062b\u064a\u0631 \u0648\u062c\u0648\u062f \u0627\u0644\u0642\u0635\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0639\u0644\u0649 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629<\/strong><\/p>\n<p>\u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0645\u0644\u0643\u0648\u0646 \u0642\u0635\u0629\u064b \u0639\u0627\u0626\u0644\u064a\u0651\u0629\u064b \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0644\u0623\u062d\u062f \u0623\u0642\u0627\u0631\u0628 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 53 \u0634\u0647\u0631\u064b\u0627 \u0645\u0642\u0627\u0628\u0644 35 \u0634\u0647\u0631\u0627\u064b \u0644\u0644\u0645\u0631\u0636\u0649 \u0645\u0645\u0646 \u0644\u064a\u0633 \u0644\u062f\u064a\u0647\u0645 \u0623\u0642\u0627\u0631\u0628 \u0645\u0646 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u064f\u0634\u062e\u0651\u0635\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646\u060c \u063a\u064a\u0631 \u0623\u0646\u0651 \u0627\u0644\u0641\u0627\u0631\u0642 \u0643\u0627\u0646 \u063a\u064a\u0631 \u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 (p= 0.30). \u0644\u062f\u0649 \u0627\u0634\u062a\u0645\u0627\u0644 \u062c\u0645\u064a\u0639 \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0642\u0631\u0628\u0649\u060c \u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0644\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0642\u0635\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u064a\u0633 \u0644\u062f\u064a\u0647\u0645 \u0642\u0635\u0629 \u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 50 \u0634\u0647\u0631\u064b\u0627 \u0645\u0642\u0627\u0628\u0644 32 \u0634\u0647\u0631\u064b\u0627\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628. \u0644\u0643\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0643\u0627\u0646 \u0623\u064a\u0636\u0627\u064b \u063a\u064a\u0631 \u0630\u064a \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0629 (p=0.079).<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062d\u062f\u062b\u064a\u0651\u0627\u062a \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0627\u0644\u062e\u062b\u0631\u064a\u0629 \u0648\u0627\u0644\u0646\u0632\u0641\u064a\u0629 \u0645\u0639 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635:<\/strong><\/p>\n<p>\u0627\u0642\u062a\u0635\u0631\u062a \u0627\u0644\u062d\u062f\u062b\u064a\u0627\u062a \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0627\u0644\u062e\u062b\u0631\u064a\u0629 \u0623\u0648 \u0627\u0644\u0646\u0632\u0641\u064a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629 (33% \u0634\u062e\u0635\u0648\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 III \u064867% \u0634\u062e\u0651\u0635\u0648\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 IV)\u060c \u0648\u0644\u0645 \u062a\u0633\u062c\u0644 \u0647\u0630\u0647 \u0627\u0644\u062d\u062f\u062b\u064a\u0627\u062a \u0641\u064a \u0623\u064a\u0651\u064d \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 I \u0648II\u060c \u0648\u0643\u0627\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651\u0627\u064b \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064b\u0627 (p= 0.008).<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0629 \u0644\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a \u0644\u0644\u0648\u0631\u0645:<\/strong><\/p>\n<p><strong>\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a \u0644\u0644\u0648\u0631\u0645 \u0639\u0644\u0649 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635<\/strong><\/p>\n<p>\u0634\u064f\u062e\u0651\u0650\u0635 \u0646\u062d\u0648 76% \u0645\u0646 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0645\u0646 \u0648\u0646\u062d\u0648 70% \u0645\u0646 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0633\u0631 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 III \u0648IV\u060c \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0644\u0644\u0641\u0627\u0631\u0642 (p= 0.616).<\/p>\n<p><strong>\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a \u0639\u0644\u0649 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0641\u0631\u0639\u064a \u0644\u0644\u0648\u0631\u0645<\/strong><\/p>\n<p>\u0634\u0643\u0651\u0644\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0627\u0644\u063a\u0627\u0632\u064a\u0629 (\u0627\u0644\u0645\u062e\u0627\u0637\u064a \u0648\u0627\u0644\u062e\u0627\u062a\u0645\u064a) \u0646\u0633\u0628\u0629\u064b \u0642\u062f\u0631\u0647\u0627 26% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0645\u0646 \u0648\u0646\u062d\u0648 19% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0633\u0631. \u0628\u0641\u0627\u0631\u0642\u064d \u063a\u064a\u0631 \u0645\u0639\u062a\u062f\u0651\u064d \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064b\u0627 (p= 0.578).<\/p>\n<p><strong>\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a \u0644\u0644\u0648\u0631\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629<\/strong><\/p>\n<p>\u062a\u0648\u0632\u0651\u0639 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0645\u0646 \u0645\u0642\u0627\u0628\u0644 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0633\u0631 \u0648\u0641\u0642\u064b\u0627 \u0644\u0644\u0645\u062d\u0635\u0644\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u0636 \u0639\u0644\u0649 \u0627\u0644\u0646\u062d\u0648 \u0627\u0644\u062a\u0627\u0644\u064a\u061b \u062d\u0642\u0651\u0642 6% \u0645\u0642\u0627\u0628\u0644 18% \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0643\u0627\u0645\u0644\u0629 \u0644\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u062a\u0631\u0642\u0649 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u0649 41% \u0645\u0642\u0627\u0628\u0644 34% \u0648\u062a\u0648\u0641\u064a 53% \u0645\u0642\u0627\u0628\u0644 48% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628\u060c \u0648\u062f\u0648\u0646 \u0648\u062c\u0648\u062f\u064d \u0644\u0641\u0627\u0631\u0642 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0630\u064a \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 (p= 0.313). \u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0651\u0629 35 \u0634\u0647\u0631\u064b\u0627 \u0645\u0642\u0627\u0628\u0644 42 \u0634\u0647\u0631\u064b\u0627 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0623\u064a\u0645\u0646 \u0648\u0627\u0644\u0623\u064a\u0633\u0631\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628\u060c \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642\u064d \u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 (p= 0.727).<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Discussion<\/strong><\/p>\n<p>\u064a\u0639\u062f \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0645\u0646 \u0645\u0633\u0628\u0628\u0651\u0627\u062a \u0627\u0644\u0648\u0641\u0627\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u064a\u0646 \u0627\u0644\u0639\u0627\u0644\u0645\u064a \u0648\u0627\u0644\u0645\u062d\u0644\u064a. (13,14) \u0634\u0647\u062f \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0645\u0627\u0636\u064a \u0627\u0632\u062f\u064a\u0627\u062f\u064b\u0627 \u0645\u0644\u062d\u0648\u0638\u064b\u0627 \u0641\u064a \u0648\u0642\u0648\u0639\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0648\u0627\u0644\u0645\u0648\u0627\u062a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0647 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0627\u0644\u0639\u0631\u0628\u064a\u060c \u0648\u0642\u062f \u0639\u064f\u0632\u0650\u064a \u0647\u0630\u0627 \u0627\u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0625\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0643\u0627\u0646 \u0623\u0628\u0631\u0632\u0647\u0627 \u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u062f\u0644 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0628\u064a\u0646 \u0627\u0644\u0639\u0631\u0628\u060c \u0648\u0642\u0644\u0629 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u062c\u0633\u062f\u064a\u060c \u0648\u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0648\u0636\u063a\u0648\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0645\u062c\u0647\u062f\u0629\u060c \u0648\u0627\u0644\u0639\u0627\u062f\u0627\u062a \u0627\u0644\u063a\u0630\u0627\u0626\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0635\u062d\u064a\u0629\u060c \u0645\u062a\u0622\u0632\u0631\u0629\u064b \u0645\u0639 \u0627\u0644\u0645\u0624\u0647\u0628\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646. 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\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0644\u0642\u0635\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u0628\u064a\u0646 \u062a\u062d\u0633\u0646 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0648\u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0643\u0633. \u0646\u0639\u062a\u0642\u062f \u0623\u0646\u0651\u064e \u0635\u063a\u0631 \u062d\u062c\u0645 \u0627\u0644\u0639\u064a\u0646\u0629 \u0648\u0627\u0644\u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0642\u062f \u062d\u0627\u0644\u0627 \u062f\u0648\u0646 \u062a\u062c\u0644\u0651\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a \u0641\u064a \u0627\u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/p>\n<p>\u0627\u062a\u0651\u0633\u0645\u062a \u062c\u0645\u0647\u0631\u0629 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u0633\u0648\u0631\u064a\u064a\u0646 \u0628\u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0623\u0639\u0645\u0627\u0631 \u0639\u0646\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635\u060c \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0642\u0635\u0629\u064c \u0639\u0627\u0626\u0644\u064a\u0651\u0629\u064c \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u064a\u0646 \u0628\u0645\u0631\u0627\u062d\u0644 \u0645\u062a\u0642\u062f\u0645\u0629. \u0643\u0627\u0646 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0628\u0645\u0631\u0627\u062d\u0644 \u0645\u062a\u0642\u062f\u0645\u0629 \u0648\u0627\u0644\u062d\u062f\u062b\u064a\u0627\u062a \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0627\u0644\u062e\u062b\u0631\u064a\u0629 \u0648\u0627\u0644\u0646\u0632\u0641\u064a\u0629 \u0627\u0644\u0639\u0627\u0645\u0644\u0627\u0646 \u0627\u0644\u0631\u0626\u064a\u0633\u0627\u0646 \u0627\u0644\u0645\u0624\u062b\u0631\u0627\u0646 \u0641\u064a \u0632\u064a\u0627\u062f\u0629 \u0646\u0633\u0628 \u0627\u0644\u0645\u0648\u0627\u062a\u0629 \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629.<\/p>\n<p>\u062a\u064f\u0628\u0631\u0650\u0632 \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0623\u0647\u0645\u064a\u0629 \u0625\u062c\u0631\u0627\u0621 \u0628\u0631\u0627\u0645\u062c \u0645\u0633\u062d\u064a\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0627\u062e\u062a\u0637\u0627\u0631 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0648\u0627\u0644\u0645\u0631\u062a\u0641\u0639\u060c \u0645\u0639 \u0627\u0644\u0623\u062e\u0630 \u0628\u0639\u064a\u0646 \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 \u0628\u062f\u0621 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u062f\u0648\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0627\u0644\u0623\u0647\u0628\u0629 \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0628\u0639\u0645\u0631 \u0623\u0635\u063a\u0631 \u0645\u0646 40 \u0639\u0627\u0645\u0627\u064b. \u062d\u0627\u0644 \u0635\u0650\u063a\u0631 \u062d\u062c\u0645 \u0627\u0644\u0639\u064a\u0646\u0629 \u0648\u0627\u0644\u0645\u062d\u062f\u0648\u062f\u064a\u0629 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u062f\u0648\u0646 \u062a\u0623\u0643\u064a\u062f \u0623\u0648 \u0646\u0641\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629\u060c \u0648\u0639\u0644\u064a\u0647 \u0646\u0648\u0635\u064a \u0628\u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0645\u062d\u0627\u0643\u064a\u0629 \u0639\u0644\u0649 \u062c\u0645\u0647\u0631\u0627\u062a\u064d \u0623\u0643\u0628\u0631 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0644\u0641\u062a\u0631\u0629 \u0645\u062a\u0627\u0628\u0639\u0629 \u0623\u0637\u0648\u0644.<\/p>\n<p><strong>\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a <\/strong><strong>List of abbreviations<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td style=\"text-align: center;\" width=\"396\"><strong>\u0627\u0644\u0645\u0635\u0637\u0644\u062d \u0627\u0644\u0645\u0642\u0627\u0628\u0644<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"228\"><strong>\u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Adenomatous Polyposis Coli<\/td>\n<td style=\"text-align: center;\" width=\"228\">APC<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Mismatch Repair Genes<\/td>\n<td style=\"text-align: center;\" width=\"228\">MMR Genes<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Syrian National Cancer Registry<\/td>\n<td style=\"text-align: center;\" width=\"228\">SNCR<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Response Evaluation Criteria In Solid\u00a0Tumors<\/td>\n<td style=\"text-align: center;\" width=\"228\">RECIST<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Complete Response<\/td>\n<td style=\"text-align: center;\" width=\"228\">CR<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Partial Response<\/td>\n<td style=\"text-align: center;\" width=\"228\">PR<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Progressive Disease<\/td>\n<td style=\"text-align: center;\" width=\"228\">PD<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Stable Disease<\/td>\n<td style=\"text-align: center;\" width=\"228\">SD<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Overall Survival<\/td>\n<td style=\"text-align: center;\" width=\"228\">OS<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">National Cancer Institute<\/td>\n<td style=\"text-align: center;\" width=\"228\">NCI<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"396\">Standard Deviation<\/td>\n<td style=\"text-align: center;\" width=\"228\">SD<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629<\/strong><strong> Ethics approval and consent to participate<\/strong><\/p>\n<p>\u062d\u0627\u0632 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0644\u062c\u0646\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0629 \u0628\u062a\u0627\u0631\u064a\u062e 2022\/1\/4. \u0636\u064f\u0645\u0646\u062a \u0627\u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u064a \u0627\u0644\u0628\u062d\u062b \u0628\u0639\u062f \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u062a\u0647\u0645 \u0627\u0644\u0645\u0633\u062a\u0646\u064a\u0631\u0629.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong><strong>Conflict of interests<\/strong><\/p>\n<p>\u064a\u064f\u0642\u0631\u0651 \u062c\u0645\u064a\u0639 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062a\u0636\u0627\u0631\u0628 \u0641\u064a \u0627\u0644\u0645\u0635\u0627\u0644\u062d \u0641\u064a\u0645\u0627 \u0628\u064a\u0646\u0647\u0645.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong><strong>Funding<\/strong><\/p>\n<p>\u0645\u064f\u0648\u0651\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u062c\u0632\u0626\u064a\u0627\u064b \u0645\u0646 \u0642\u0628\u0644 \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0648\u062a\u062d\u0645\u0644\u062a \u0627\u0644\u0628\u0627\u062d\u062b\u0629 \u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u0643\u0627\u0644\u064a\u0641 \u0627\u0644\u0623\u062e\u0631\u0649.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong><strong>Authors\u2019 contributions<\/strong><\/p>\n<p>\u062a\u0645 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0645\u062c\u062f \u0627\u0644\u062c\u0645\u0627\u0644\u064a \u0648\u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0629 \u0644\u0645\u0649 \u064a\u0648\u0633\u0641 \u0648\u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0631\u0627\u0626\u062f \u0623\u0628\u0648 \u062d\u0631\u0628\u060c \u0648\u0642\u0627\u0645\u062a \u064a\u0633\u0631\u0649 \u0627\u0644\u0646\u0627\u0635\u0631 \u0628\u062c\u0645\u0639 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0648\u0627\u0644\u062a\u0651\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u060c \u0648\u0634\u0627\u0631\u0643 \u0643\u0644\u0651 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0641\u064a \u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0646\u0651\u062a\u0627\u0626\u062c \u0648\u0643\u062a\u0627\u0628\u0629 \u0648\u0635\u064a\u0627\u063a\u0629 \u0645\u062e\u0637\u0648\u0637\u0629 \u0627\u0644\u0628\u062d\u062b \u0648\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u062e\u0637\u0648\u0637\u0629 \u0627\u0644\u0646\u0651\u0647\u0627\u0626\u064a\u0651\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647\u0627.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u0633\u0631\u0637\u0627\u0646\u064f \u0627\u0644\u0642\u0648\u0644\u0648\u0646\u0650 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645\u0650 \u062f\u0627\u0621\u064c \u062e\u0628\u064a\u062b\u064c \u0645\u062a\u063a\u0627\u064a\u0631\u060c \u064a\u0628\u062f\u0623 \u0628\u0646\u0645\u0648\u0651\u064d \u063a\u064a\u0631 \u0645\u0636\u0628\u0648\u0637\u064d \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0634\u0643\u0651\u0650\u0644 \u0628\u062f\u0621\u0627\u064b \u0646\u0627\u0645\u064a\u0629\u064b \u0635\u063a\u064a\u0631\u0629\u064b \u062a\u062f\u0639\u0649 \u0633\u0644\u064a\u0644\u0629 polyp\u060c \u062a\u062a\u0637\u0648\u0631&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=1958\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":1964,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-1958","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-155","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/1958","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1958"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/1958\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/1964"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1958"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1958"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}