{"id":196,"date":"2022-04-01T19:22:09","date_gmt":"2022-04-01T19:22:09","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=196"},"modified":"2024-07-21T17:40:55","modified_gmt":"2024-07-21T17:40:55","slug":"%d8%aa%d8%a3%d8%ab%d9%8a%d8%b1-%d8%a7%d9%84%d8%aa%d9%91%d8%b9%d8%af%d9%91%d8%af-%d8%a7%d9%84%d8%b4%d9%91%d9%83%d9%84%d9%8a-%d9%85%d9%81%d8%b1%d8%af-%d8%a7%d9%84%d9%86%d9%88%d9%83%d9%84%d9%8a%d9%88","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=196","title":{"rendered":"\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062a\u0651\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f -1639G>A VKORC1 \u0641\u064a \u0627\u0644\u0623\u0647\u0628\u0629 \u0644\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a\u0651 \u0627\u0644\u0648\u0631\u064a\u062f\u064a\u0651 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0627\u0644\u0633\u0651\u0648\u0631\u064a\u0651\u064a\u0646: \u062a\u0623\u062b\u064a\u0631 \u0648\u0642\u0627\u0626\u064a \u0623\u0645 \u0639\u0627\u0645\u0644 \u0627\u062e\u062a\u0637\u0627\u0631\u061f"},"content":{"rendered":"

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SNP \u0641\u064a \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0645\u062d\u0636\u0651\u0636 promoter \u0648\u064a\u0624\u062f\u064a \u0648\u062c\u0648\u062f \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f A \u0639\u0648\u0636\u0627\u064b \u0639\u0646 G \u0625\u0644\u0649 \u062a\u0639\u062f\u064a\u0644\u064d \u0641\u064a \u0645\u0646\u0637\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0627\u0646\u062a\u0633\u0627\u062e \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0628\u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0629 \u0625\u0644\u0649 \u0627\u0646\u062e\u0641\u0627\u0636\u064d \u0641\u064a \u0627\u0644\u062a\u0651\u0639\u0628\u064a\u0631 \u0639\u0646 \u0625\u0646\u0632\u064a\u0645 VKORC1.(13)<\/sup> \u0648\u0627\u0646\u0637\u0644\u0627\u0642\u0627\u064b \u0645\u0646 \u062a\u0623\u062b\u064a\u0631 VKORC1 \u0627\u0644\u0645\u0647\u0645\u0651 \u0641\u064a \u0646\u0638\u0627\u0645 \u0627\u0644\u062a\u0651\u062e\u062b\u0651\u0631\u060c \u064a\u064f\u0639\u062a\u0642\u062f \u0625\u0633\u0647\u0627\u0645\u0647 \u0641\u064a \u0627\u062e\u062a\u0644\u0627\u0641 \u062a\u0623\u0647\u0628 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0644\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a \u062a\u0628\u0639\u0627\u064b \u0644\u0644\u062a\u0651\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0627\u0644\u0630\u064a \u064a\u062d\u0645\u0644\u0647 \u0627\u0644\u0641\u0631\u062f\u060c \u0641\u062d\u0645\u0644\u0629 \u0627\u0644\u0623\u0644\u064a\u0644 A \u0631\u0628\u0645\u0627 \u064a\u0643\u0648\u0646\u0648\u0646 \u0623\u0642\u0644 \u0639\u0631\u0636\u0629 \u0644\u062d\u062f\u0648\u062b \u0627\u0644\u062e\u062b\u0627\u0631 \u0645\u0646 \u062d\u0645\u0644\u0629 \u0627\u0644\u0623\u0644\u064a\u0644 G.(15)<\/sup> \u0648\u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0645\u0627 \u0633\u0628\u0642\u060c 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\n-1639G>A<\/em> \u0648\u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a\u0651 \u0627\u0644\u0648\u0631\u064a\u062f\u064a\u0651\u060c \u0648\u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u062a\u0648\u0627\u062a\u0631\u0647 \u0644\u062f\u0649 \u0623\u0641\u0631\u0627\u062f \u0633\u0648\u0631\u064a\u0651\u064a\u0646 \u0644\u062a\u0642\u064a\u0651\u064a\u0645 \u062c\u062f\u0648\u0649 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0647\u0630\u0627 \u0627\u0644\u062a\u0651\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0641\u064a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0623\u0648 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0629.<\/span><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0651\u0631\u0627\u0626\u0642 <\/strong>\u00a0Materials and Methods<\/strong><\/span><\/p>\n

\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0648\u0623\u0641\u0631\u0627\u062f\u0647\u0627<\/strong><\/span><\/p>\n

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\u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a <\/strong><\/span><\/p>\n

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\u0628\u0639\u062a\u064a\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u0644\u0627\u0635 Wizard \u00ae Genomic DNA Purification Kit. \u0623\u064f\u062c\u0631\u064a\u064e \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u062a\u0651\u0633\u0644\u0633\u0644\u064a\u0651 polymerase chain reaction (PCR) \u0628\u0647\u062f\u0641 \u062a\u0636\u062e\u064a\u0645 \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0645\u0646 \u0627\u0644\u0645\u062d\u0636\u0651\u0636 promoter \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0640 SNP \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0641\u064a \u062c\u064a\u0646 VKORC1<\/em>. \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0623\u062f\u0628\u064a\u0627\u062a\u060c(16)<\/sup>\u060c<\/sup>(17)<\/sup>\u060c<\/sup>(18)<\/sup>\u060c<\/sup>(19)<\/sup> \u0627\u0633\u062a\u064f\u0639\u0645\u0644 \u0628\u062f\u0627\u064a\u0629\u064b 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\u0633\u064a\u0624\u0648\u0644\u060c \u0643\u0648\u0631\u064a\u0627 \u0627\u0644\u062c\u0646\u0648\u0628\u064a\u0629).<\/span><\/p>\n

\u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a<\/strong><\/span><\/p>\n

\u062d\u064f\u0644\u0651\u0644\u062a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651 SPSS\u00ae Statistical Package for the Social Sciences (\u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0627\u0644\u062e\u0627\u0645\u0633 \u0648\u0627\u0644\u0639\u0634\u0631\u0648\u0646) \u0648\u0628\u0631\u0645\u062c\u064a\u0651\u0629 \u00aeGraphPad Prism (\u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0627\u0644\u062b\u0651\u0627\u0645\u0646). \u0642\u064f\u064a\u0651\u0645 \u0627\u0644\u062a\u0651\u0648\u0632\u0639 \u0627\u0644\u0637\u0651\u0628\u064a\u0639\u064a \u0644\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0639\u0628\u0631 \u0627\u062e\u062a\u0628\u0627\u0631 Shapiro-Wilk. \u0639\u064f\u0628\u0651\u0631 \u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0643\u0645\u064a\u0651\u0629 \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0651\u0629 (\u0623\u0639\u0645\u0627\u0631 \u0627\u0644\u0645\u0631\u0636\u0649) \u0627\u0644\u062a\u064a \u062a\u062a\u0628\u0639 \u0627\u0644\u062a\u0651\u0648\u0632\u0639 \u0627\u0644\u0637\u0651\u0628\u064a\u0639\u064a \u0628\u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a\u060c \u0648\u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0651\u0629 \u0627\u0644\u062a\u064a \u0644\u0627 \u062a\u062a\u0628\u0639 \u0627\u0644\u062a\u0651\u0648\u0632\u0639 \u0627\u0644\u0637\u0651\u0628\u064a\u0639\u064a (\u0623\u0639\u0645\u0627\u0631 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f) \u0628\u0627\u0644\u0648\u0633\u064a\u0637 \u00b1\u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0631\u0651\u0628\u064a\u0639\u064a\u060c \u0623\u0645\u0627 \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u0627\u062a \u0627\u0644\u0625\u0633\u0645\u064a\u0629 \u0641\u0628\u0627\u0644\u062a\u0648\u0627\u062a\u0631 \u0648\u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629. \u0627\u0633\u062a\u064f\u0639\u0645\u0644 \u0627\u062e\u062a\u0628\u0627\u0631 \u0641\u064a\u0634\u0631 Fisher’s exact test \u0644\u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0645\u0642\u0627\u0631\u0646\u0629 \u0641\u064a \u062d\u0627\u0644 \u0648\u062c\u0648\u062f \u0645\u062a\u063a\u064a\u0651\u0631\u064a\u0646 \u0627\u0633\u0645\u064a\u0651\u064a\u0646 \u0641\u0642\u0637\u060c \u0648\u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0645\u0631\u0628\u0651\u0639 Chi-square test \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u0627\u062a \u0627\u0644\u0641\u0626\u0648\u064a\u0629. \u0643\u0645\u0627 \u062c\u0631\u0649 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u062e\u062a\u0628\u0627\u0631 Mann-Whitney U \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0644\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0651\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u0648\u0632\u0651\u0639\u0629 \u0637\u0628\u064a\u0639\u064a\u0651\u0627\u064b. \u062d\u064f\u0633\u0628 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644\u064a\u0646 A \u0648G \u0628\u0642\u0633\u0645\u062a\u0647\u0627 \u0639\u0644\u0649 \u0639\u062f\u062f \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0627\u0644\u0643\u0651\u0644\u064a. \u0627\u0633\u062a\u0639\u0645\u0644 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0645\u0631\u0628\u0651\u0639 \u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0648\u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u0645\u0634\u0627\u0647\u062f\u0629 \u0648\u0627\u0644\u0645\u062a\u0648\u0642\u0651\u0639\u0629 \u0648\u0641\u0642\u0627\u064b \u0644\u062a\u0648\u0627\u0632\u0646 \u0647\u0627\u0631\u062f\u064a \u0648\u0627\u064a\u0646\u0628\u0631\u063a (HWE) Hardy-Weinberg Equilibrium. \u0627\u0639\u062a\u064f\u0645\u062f\u062a P<0.05 \u0643\u0642\u064a\u0645\u0629\u064d \u062f\u0644\u0627\u0644\u0629\u064d \u0645\u0639\u062a\u062f\u0651\u064d \u0628\u0647\u0627 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u0645\u0637\u0628\u0651\u0642\u0629.<\/span><\/p>\n

\u0627\u0644\u0646\u062a\u0627\u0626\u062c<\/strong> Results<\/strong><\/span><\/p>\n

\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n

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\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a<\/strong><\/span><\/p>\n

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\u0627\u0644\u0634\u0651\u0643\u0644 (2). \u0645\u0646\u062a\u062c \u0627\u0644\u0640 PCR \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0632\u0648\u062c \u0627\u0644\u0645\u0634\u0627\u0631\u0639 \u0627\u0644\u0648\u0627\u0631\u062f \u0641\u064a \u0627\u0644\u0623\u062f\u0628\u064a\u0651\u0627\u062a. A: \u0633\u0644\u0645 \u0645\u0626\u0648\u064a \u0644\u0623\u0637\u0648\u0644 \u0642\u0637\u0639 \u0627\u0644\u0640 DNA\u060c B: \u0639\u064a\u0646\u0629 \u0628\u062f\u0631\u062c\u0629 \u062a\u0644\u062f\u064a\u0646 \u2070C 64 \u0648\u0641\u0642 \u0634\u0631\u0648\u0637 Rafiee et al\u060c C: \u0630\u0627\u062a \u0627\u0644\u0639\u064a\u0646\u0629 \u0628\u062f\u0631\u062c\u0629 \u062a\u0644\u062f\u064a\u0646 \u2070C 60 \u062a\u0638\u0647\u0631 \u0627\u0644\u0645\u0646\u062a\u062c \u0627\u0644\u0645\u0637\u0644\u0648\u0628 \u0645\u0639 \u0644\u0637\u0627\u062e\u0629 \u0645\u0646\u062a\u062c\u0627\u062a \u062b\u0627\u0646\u0648\u064a\u0651\u0629.<\/span><\/strong><\/figcaption><\/figure>\n
\"\u0627\u0644\u0634\u0651\u0643\u0644
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\"\u0627\u0644\u0634\u0651\u0643\u0644
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\"\u0627\u0644\u0634\u0643\u0644
\u0627\u0644\u0634\u0643\u0644 (5). \u0627\u0644\u0645\u062e\u0637\u0637 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628\u064a Chromatogram \u0644\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u0640 DNA \u0641\u064a \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0640 SNP \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0644\u062c\u064a\u0646 VKORC1 \u064a\u0648\u0636\u062d \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629. A \u0645\u062b\u0627\u0644 \u064a\u0648\u0636\u062d \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 GG\u060c B \u064a\u0645\u062b\u0644 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0627\u0644\u0637\u0651\u0627\u0641\u0631 AA\u060c C \u064a\u0645\u062b\u0644 \u0627\u0644\u0646\u0651\u0645\u0637 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a GA<\/span><\/strong><\/figcaption><\/figure>\n

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\u062d\u0642\u0642 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u0632\u064a\u062c\u0648\u062a GA \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0623\u0639\u0644\u0649 \u0628\u064a\u0646 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0628\u0646\u0633\u0628\u0629 \u00a0\u0642\u062f\u0631\u0647\u0627 64.8%\u060c \u062a\u0644\u0627\u0647 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 GG \u0628\u0646\u0633\u0628\u0629 22.2%\u060c \u0644\u064a\u062d\u0644\u0651\u064e \u0627\u0644\u0646\u0651\u0645\u0637 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0627\u0644\u0637\u0651\u0627\u0641\u0631 AA \u0623\u062e\u064a\u0631\u0627\u064b \u0628\u0646\u0633\u0628\u0629 \u0642\u062f\u0631\u0647\u0627 13%. \u0648\u0628\u0630\u0644\u0643 \u064a\u0643\u0648\u0646 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 (G) 0.55 \u0648\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0651\u0627\u0641\u0631 (A) 0.45.\u00a0 \u0628\u0635\u0648\u0631\u0629 \u0645\u0634\u0627\u0628\u0647\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649\u060c \u0643\u0627\u0646 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a GA \u0627\u0644\u0623\u0639\u0644\u0649 \u0644\u062f\u0649 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0628\u0646\u0633\u0628\u0629 \u0642\u062f\u0631\u0647\u0627 86.4%\u060c \u0641\u064a \u062d\u064a\u0646 \u062a\u0633\u0627\u0648\u0649 \u0627\u0644\u0646\u0645\u0637\u0627\u0646 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 GG \u0648\u0627\u0644\u0637\u0651\u0627\u0641\u0631 AA \u0645\u0646 \u062d\u064a\u062b \u0646\u0633\u0628\u062a\u0627 \u0627\u0646\u062a\u0634\u0627\u0631\u0647\u0645\u0627 \u0627\u0644\u0628\u0627\u0644\u063a\u0629 6.8%. \u0648\u0628\u0647\u0630\u0627 \u062a\u0633\u0627\u0648\u0649 \u062a\u0648\u0627\u062a\u0631\u0627 \u0627\u0644\u0623\u0644\u0651\u064a\u0644\u064a\u0646 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 (G) \u0648\u0627\u0644\u0637\u0651\u0627\u0641\u0631 (A) \u0644\u062f\u0649 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0625\u0630 \u0628\u0644\u063a 0.5 \u0644\u0643\u0644\u0651\u064d \u0645\u0646\u0647\u0645\u0627. \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u0645\u0634\u0627\u0647\u062f\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0643\u0644\u062a\u064a\u0647\u0645\u0627 \u0627\u0646\u062d\u0631\u0627\u0641\u0627\u064b \u0639\u0646 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0651\u0629 \u0648\u0641\u0642 \u062a\u0648\u0627\u0632\u0646 \u0647\u0627\u0631\u062f\u064a \u0648\u0627\u064a\u0646\u0628\u0631\u063a HWE\u060c \u0625\u0630 \u0643\u0627\u0646\u062a 0.024= P<\/em> \u0648\u0623\u0642\u0644 \u0645\u0646 0.001 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0651\u0631\u062a\u064a\u0628.<\/span><\/p>\n

\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0628\u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a\u0651 \u0627\u0644\u0648\u0631\u064a\u062f\u064a\u0651<\/strong><\/span><\/p>\n

\u0644\u062f\u0649 \u0645\u0642\u0627\u0631\u0646\u062a\u0646\u0627 \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0628\u064a\u0646 \u0630\u0631\u0627\u0639\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u0643\u0627\u0646 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 GG \u062c\u0644\u064a\u0651\u0627\u064b \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 (22.2%) \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0623\u0635\u062d\u0627\u0621 (6.8%). \u0648\u0643\u0627\u0646 \u0647\u0630\u0627 \u0627\u0644\u062a\u0651\u0648\u0632\u0639 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u0643\u0627\u0641\u0626 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0651\u0627\u0641\u0631 A (GA \u0648AA) \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0623\u0641\u0631\u0627\u062f \u063a\u064a\u0631 \u0627\u0644\u062d\u0627\u0645\u0644\u064a\u0646 \u0644\u0647 \u0630\u0648\u064a \u0627\u0644\u0646\u0651\u0645\u0637 (GG) \u0645\u0639\u062a\u062f\u0651\u0627\u064b \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (P<\/em>=0.048)\u060c \u062d\u064a\u062b \u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u062d\u0645\u0644\u0629 \u0627\u0644\u0623\u0644\u064a\u0644 A \u0646\u0633\u0628\u0629 \u0623\u0639\u0644\u0649 93.2% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0640 77.8% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649. \u062a\u0631\u0627\u0641\u0642\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062d\u0627\u0645\u0644\u0629 \u0644\u0644\u0623\u0644\u064a\u0644 A \u0628\u0627\u0646\u062e\u0641\u0627\u0636\u064d \u0641\u064a \u0627\u062e\u062a\u0637\u0627\u0631 \u062d\u062f\u0648\u062b \u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0625\u0644\u0649 \u0627\u0644\u0631\u0651\u0628\u0639 \u062a\u0642\u0631\u064a\u0628\u0627\u064b\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0631\u062c\u062d\u064a\u0629 odd ratio \u0648\u0645\u062c\u0627\u0644 \u0627\u0644\u062b\u0651\u0642\u0629 (OR=0.256, 95% CI=0.074-0.925). \u0648\u062a\u0631\u0627\u0641\u0642 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0634\u0651\u0627\u0626\u0639 GG \u0628\u0627\u062e\u062a\u0637\u0627\u0631 \u0623\u0639\u0644\u0649 \u0644\u062d\u062f\u0648\u062b \u0627\u0644\u0645\u0631\u0636 \u064a\u0642\u0627\u0631\u0628 \u0627\u0644\u0623\u0631\u0628\u0639\u0629 \u0623\u0636\u0639\u0627\u0641 <\/span>
\n(OR=3.9, 95% CI=1.081-13.56). \u0644\u0645 \u064a\u0643\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0645\u0646 \u062d\u064a\u062b \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 A \u0645\u0639\u062a\u062f\u0627\u064b \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P<\/em>=0.566)\u060c \u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646\u0647 \u0623\u0639\u0637\u0649 \u0627\u062d\u062a\u0645\u0627\u0644\u0627\u064b \u0623\u0642\u0644 \u0628\u0640 17% \u0645\u0646 \u062d\u0645\u0644\u0629 \u0627\u0644\u0623\u0644\u0651\u064a\u0644 G \u0644\u062d\u062f\u0648\u062b \u0627\u0646\u0635\u0645\u0627\u0645 \u062e\u062b\u0627\u0631\u064a\u060c \u0625\u0644\u0627 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645\u0629 \u0644\u0645 \u064a\u0643\u0646 \u0645\u0639\u062a\u062f\u0627\u064b \u0628\u0647\u0627. \u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 2 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0648\u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629.<\/span><\/p>\n

\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629<\/strong> Discussion<\/strong><\/span><\/p>\n

\u064a\u0642\u0648\u0645 \u0627\u0644\u0637\u0651\u0628 \u0627\u0644\u0645\u0634\u062e\u0635\u0646 personalized medicine \u0639\u0644\u0649 \u0645\u0628\u062f\u0623 \u0639\u0644\u0627\u062c \u0643\u0644 \u0645\u0631\u064a\u0636 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0637\u064a\u0627\u062a \u0627\u0644\u0628\u064a\u0626\u064a\u0651\u0629 \u0648\u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0651\u0629 \u0648\u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062e\u0627\u0635\u0651\u0629 \u0628\u0647\u060c \u0648\u0642\u062f \u0634\u0647\u062f \u0645\u0624\u062e\u0631\u0627\u064b \u062a\u062d\u062f\u064a\u062b\u0627\u0651 \u0648\u0633\u0651\u0639 \u0645\u0646 \u0625\u0637\u0627\u0631\u0647 \u0644\u064a\u0634\u0645\u0644 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0627\u0644\u0645\u0634\u062e\u0635\u0646\u0629 \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636. \u062a\u0634\u0645\u0644 \u0623\u062d\u062f \u0623\u0648\u062c\u0647 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\"\"<\/strong><\/span><\/p>\n

\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong><\/span><\/p>\n

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\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u064a\u0636\u0645\u0651 \u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a\u0651 \u0627\u0644\u0648\u0631\u064a\u062f\u064a\u0651 Venous (VTE) Thromboembolism \u062d\u0627\u0644\u062a\u064a\u0646 \u0645\u0631\u0636\u064a\u062a\u064a\u0646 \u0631\u0626\u064a\u0633\u064a\u0651\u062a\u064a\u0646 \u0647\u0645\u0627 \u0627\u0644\u062e\u062b\u0627\u0631 \u0627\u0644\u0648\u0631\u064a\u062f\u064a\u0651 \u0627\u0644\u0639\u0645\u064a\u0642 Deep Vein (DVT) Thrombosis \u0648\u0627\u0644\u0635\u0651\u0645\u0651\u0629 \u0627\u0644\u0631\u0651\u0626\u0648\u064a\u0629…
\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":475,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-196","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-133","volume-8"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=196"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/196\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/475"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}