{"id":1974,"date":"2025-04-26T13:52:56","date_gmt":"2025-04-26T13:52:56","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=1974"},"modified":"2025-04-29T09:37:12","modified_gmt":"2025-04-29T09:37:12","slug":"%d8%af%d8%b1%d8%a7%d8%b3%d8%a9-%d8%a7%d9%84%d8%aa%d9%8e%d9%91%d8%a3%d8%ab%d9%8a%d8%b1%d8%a7%d8%aa-%d8%a7%d9%84%d9%88%d9%82%d8%a7%d8%a6%d9%8a%d9%8e%d9%91%d8%a9-%d9%84%d9%84%d8%a3%d8%aa%d9%88%d8%b1","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=1974","title":{"rendered":"\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0651\u064e\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 \u0644\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0642\u0631\u062d\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u064f\u062d\u062f\u064e\u062b\u0629 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\u0627\u0644\u0639\u0636\u0644\u064a\u0651\u064e\u0629 muscularis mucosae \u0641\u064a \u0643\u0644\u0651\u064d \u0645\u0650\u0646\u0652 \u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u0639\u062f\u0629 \u0623\u0648 \u0627\u0644\u0627\u062b\u0646\u064a \u0639\u0634\u0631 \u0639\u0644\u0649 \u0627\u0644\u062a\u0651\u064e\u0631\u062a\u064a\u0628 (1)\u060c \u064a\u064f\u0642\u062f\u0651\u064e\u0631 \u0645\u0639\u062f\u0651\u064e\u0644\u064f \u0627\u0646\u062a\u0634\u0627\u0631 \u0645\u0631\u0636 \u0627\u0644\u0642\u0631\u062d\u0629 \u0627\u0644\u0647\u0636\u0645\u064a\u0651\u064e\u0629 \u0628\u064a\u0646 \u0627\u0644\u0633\u0643\u0651\u064e\u0627\u0646 \u0639\u0627\u0645\u0651\u064e\u0629\u064b \u0628\u062d\u0648\u0627\u0644\u064a 5-10%\u060c \u0648\u0645\u0639\u062f\u0651\u064e\u0644\u064f \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0647 0.1-0.3% \u0633\u0646\u0648\u064a\u0651\u064e\u0627\u064b (2).<\/p>\n<p>\u062a\u062a\u0636\u0645\u0651\u064e\u0646\u064f 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\u0627\u0644\u0645\u064e\u0644\u0652\u0648\u0650\u064a\u0651\u064e\u0629 \u0627\u0644\u0628\u0648\u0627\u0628\u064a\u0651\u064e\u0629 Helicobacter pylori (3)<strong>\u060c <\/strong>\u0643\u0645\u0627 \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0624\u062f\u0650\u0651\u064a \u0627\u0644\u0639\u062f\u064a\u062f\u064f \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u064f \u0627\u0644\u0645\u0636\u0627\u062f\u0651\u064e\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u063a\u064a\u0631 \u0627\u0644\u0633\u062a\u064a\u0631\u0648\u0626\u064a\u062f\u064a\u0651\u064e\u0629 Non-Steroidal Anti-inflammatory Drugs (NSAIDs)\u060c \u0648\u0645\u0643\u0645\u0651\u0650\u0644\u0627\u062a\u064f \u0627\u0644\u0628\u0648\u062a\u0627\u0633\u064a\u0648\u0645\u060c \u0648\u0627\u0644\u0628\u064a\u0633\u0641\u0648\u0633\u0641\u0648\u0646\u0627\u062a\u060c 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(5)\u060c \u064a\u064f\u0633\u062a\u062e\u062f\u064e\u0645\u064f \u0627\u0644\u0645\u0627\u0644\u0648\u0646 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0623\u0644\u062f\u0647\u064a\u062f MDA \u0639\u0644\u0649 \u0646\u0637\u0627\u0642\u064d \u0648\u0627\u0633\u0639\u064d \u0643\u0639\u0644\u0627\u0645\u0629 \u062d\u064a\u0648\u064a\u0651\u064e\u0629\u064d \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0651\u0650 \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0651\u064e\u0629\u0650 \u0627\u0644\u062d\u064a\u0648\u064a\u0651\u064e\u0629 (6).<\/p>\n<p>\u064a\u0639\u062a\u0645\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062f\u0651\u064e\u0648\u0627\u0626\u064a\u0651\u064f \u0639\u0644\u0649 \u062a\u0635\u062d\u064a\u062d \u0647\u0630\u0627 \u0627\u0644\u062e\u0644\u0644: \u0625\u0645\u0651\u064e\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u062f\u0650\u0651\u0641\u0627\u0639\u0627\u062a \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u062f\u0648\u064a\u0629\u064d\u060c \u0645\u062b\u0644: \u0627\u0644\u0633\u0643\u0631\u0627\u0644\u0641\u0627\u062a<\/p>\n<p>&nbsp;<\/p>\n<p>Sucralfate\u060c \u0648\u0627\u0644\u0628\u0632\u0645\u0648\u062a Bismuth\u060c \u0648\u0645\u064f\u0636\u0627\u0647\u064a\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u063a\u0644\u0627\u0646\u062f\u064a\u0646 Prostaglandins Analogues\u060c \u0623\u0648 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0639\u062f\u0651\u0650\u0644\u0629 \u0644\u0644\u062d\u0645\u0636\u060c \u0645\u062b\u0644: \u0645\u0636\u0627\u062f\u0651\u0627\u062a \u0627\u0644\u062d\u0645\u0648\u0636\u0629 Antacids\u060c \u0623\u0648 \u062a\u0642\u0644\u064a\u0644 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u062d\u0645\u0636 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\u0628\u0627\u0644\u0625\u0646\u062f\u0648\u0645\u064a\u062a\u0627\u0633\u064a\u0646 (10).<\/p>\n<p>\u0644\u0643\u0646\u0651\u064e \u062a\u0623\u062b\u064a\u0631\u0627\u062a\u0650 \u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0650\u0646\u064e \u0627\u0644\u0642\u0631\u062d\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u062d\u062f\u062b\u0629 \u0628\u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0644\u0645 \u062a\u064f\u062f\u0631\u0633\u0652 \u0628\u0639\u062f\u064f\u060c \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646\u0651\u064e \u0627\u0644\u0634\u0651\u0650\u062f\u0651\u064e\u0629 \u0627\u0644\u062a\u0651\u064e\u0623\u0643\u0633\u062f\u064a\u0651\u064e\u0629 \u0647\u064a \u0645\u0650\u0646\u064e \u0627\u0644\u0622\u0644\u064a\u0651\u064e\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0651\u064e\u0629\u0650 \u0641\u064a \u0627\u0644\u0642\u0631\u062d\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u062d\u062f\u064e\u062b\u0629 \u0628\u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0627\u0644\u0651\u064e\u062a\u064a \u062a\u064e\u062d\u064f\u062f\u0651\u064f \u0645\u0646 \u0627\u0633\u062a\u0639\u0645\u0627\u0644\u0647\u060c \u0644\u0630\u0644\u0643 \u0647\u062f\u0641\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0625\u0644\u0649 \u062a\u0642\u0635\u0651\u0650\u064a \u0627\u0644\u062a\u0651\u064e\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 \u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0642\u0631\u062d\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u062d\u062f\u062b\u0629 \u0628\u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0639\u0646\u062f \u062c\u0631\u0630\u0627\u0646 \u0627\u0644\u062a\u0651\u064e\u062c\u0631\u0628\u0629.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Materials and Methods<\/strong><\/p>\n<p><strong>\u0645\u0643\u0627\u0646 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062f\u0631\u0627\u0633\u0629: <\/strong><\/p>\n<p>\u0623\u064f\u062c\u0631\u064a\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0643\u0644\u064a\u0651\u064e\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0629 \u0628\u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642\u064e.<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0643\u0648\u0627\u0634\u0641 \u0648\u0627\u0644\u0623\u062f\u0648\u0627\u062a: <\/strong><\/p>\n<p>\u062f\u0648\u0627\u0621\u064f \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0628\u0634\u0643\u0644 \u0645\u0633\u062d\u0648\u0642\u064d \u062c\u0627\u0647\u0632\u064d \u0644\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u060c \u062f\u0648\u0627\u0621\u064f \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0628\u0634\u0643\u0644 \u0645\u0633\u062d\u0648\u0642\u064d\u060c \u0633\u064a\u0631\u0648\u0645 \u0645\u0644\u062d\u064a 0.9%\u060c \u062b\u0646\u0627\u0626\u064a \u0625\u064a\u062a\u064a\u0644 \u0627\u0644\u0625\u064a\u062b\u0631\u060c \u0641\u0648\u0631\u0645\u0648\u0644 10%\u060c \u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a\u060c \u062d\u0645\u0636 \u0627\u0644\u062a\u064a\u0648\u0628\u0627\u0631\u0628\u064a\u062a\u0648\u0631\u064a (TBA)\u060c \u062d\u0645\u0636 \u0627\u0644\u062e\u0644\u0651\u0650 \u0645\u062b\u0644\u062b \u0627\u0644\u0643\u0644\u0648\u0631 (TCA)\u060c \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 (HCl)\u060c \u0623\u0646\u0627\u0628\u064a\u0628 \u062a\u0646\u0628\u064a\u0628 \u0641\u0645\u0648\u064a\u0651\u0650\u060c \u0633\u064a\u0631\u0646\u063a\u0627\u062a \u0627\u0644\u0627\u0646\u0633\u0648\u0644\u064a\u0646\u060c \u0645\u0645\u0635 \u0645\u064a\u0643\u0631\u0648\u0646\u064a\u060c \u0645\u064a\u0632\u0627\u0646 \u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a\u060c \u0627\u0644\u0645\u062b\u0641\u0644\u0629 \u0627\u0644\u062f\u0648\u0627\u0631\u0629\u060c \u0645\u062c\u0645\u062f\u0629 (-80 \u00b0C)\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u062c\u0627\u0646\u0633\u0629 \u0628\u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0651\u064e\u0629\u060c \u062c\u0647\u0627\u0632 \u0633\u0628\u064a\u0643\u062a\u0631\u0648\u0641\u0648\u062a\u0648\u0645\u062a\u0631.<\/p>\n<p><strong>\u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u0628\u0629:<\/strong><\/p>\n<p>\u062a\u0645\u0651\u064e \u0627\u0644\u0639\u0645\u0644 \u0639\u0644\u0649 28 \u062c\u064f\u0631\u0652\u0630\u064e\u0627\u064b \u0628\u0639\u062f \u0627\u0644\u0627\u0646\u062a\u0638\u0627\u0631 \u0644\u0645\u062f\u0651\u064e\u0629 \u0633\u0628\u0639\u0629 \u0623\u064a\u0651\u064e\u0627\u0645\u064d \u062d\u062a\u0651\u064e\u0649 \u062a\u062a\u0623\u0642\u0644\u0645 \u0627\u0644\u062c\u0631\u0630\u0627\u0646\u064f \u0641\u064a \u062d\u0648\u0627\u0636\u0646 \u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0645\u0639 \u0627\u0644\u0638\u0631\u0648\u0641 \u0627\u0644\u0645\u062d\u064a\u0637\u0629\u060c \u062d\u064a\u062b \u0648\u064f\u0636\u0650\u0639\u064e\u062a\u0652 \u0641\u064a \u0623\u0642\u0641\u0627\u0635\u064d \u0636\u0645\u0646 \u063a\u0631\u0641\u0629\u064d \u062c\u064a\u0651\u0650\u062f\u0629\u0650 \u0627\u0644\u062a\u0647\u0648\u064a\u0629 \u0648\u0627\u0644\u0625\u0636\u0627\u0621\u0629 \u0645\u0639\u0631\u064e\u0651\u0636\u0629\u064d \u0644\u0640 12\/12 \u0633\u0627\u0639\u0629\u064d \u0645\u0646 \u062d\u0644\u0642\u0629 \u0636\u0648\u0621\/\u0638\u0644\u0627\u0645 \u0648\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 (23 \u00b1 2\u00baC)\u060c \u0645\u0639 \u0633\u0647\u0648\u0644\u0629 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0637\u0639\u0627\u0645 \u0648\u0645\u0627\u0621 \u0627\u0644\u0634\u0631\u0628\u060c \u0648\u0628\u0639\u062f \u0630\u0644\u0643 \u0642\u064f\u0633\u0651\u0650\u0645\u064e\u062a\u0652 \u0625\u0644\u0649 \u0623\u0631\u0628\u0639 \u0645\u062c\u0645\u0648\u0639\u0627\u062a\u064d \u062a\u0645\u0651\u064e \u0627\u062e\u062a\u064a\u0627\u0631 \u0623\u0641\u0631\u0627\u062f\u0647\u0627 \u0628\u0634\u0643\u0644\u064d \u0639\u0634\u0648\u0627\u0626\u064a\u0651\u064d\u060c \u062d\u064a\u062b \u062a\u062d\u0648\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0627\u0644\u0623\u064f\u0648\u0644\u0649 \u0648\u0627\u0644\u0631\u0651\u064e\u0627\u0628\u0639\u0629 6 \u062c\u0631\u0630\u0627\u0646\u064d\u060c \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0627\u0644\u062b\u0651\u064e\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u062b\u0651\u064e\u0627\u0644\u062b\u0629 8 \u062c\u0631\u0630\u0627\u0646\u064d\u060c \u0628\u062d\u064a\u062b\u064f \u0644\u0627 \u064a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u0623\u0643\u062b\u0631\u064e \u0645\u0650\u0646\u0652 4 \u062c\u0631\u0630\u0627\u0646\u064d \u0641\u064a \u0627\u0644\u0642\u0641\u0635 \u0627\u0644\u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0646\u0651\u064e\u062d\u0648 \u0627\u0644\u0622\u062a\u064a:<\/p>\n<p><strong>\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 <\/strong><strong>Natural Control group (NC)<\/strong><strong>:<\/strong> \u0646\u064f\u0628\u0651\u0650\u0628\u064e\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u0645\u0648\u064a\u0651\u064e\u0627\u064b \u0628\u0627\u0644\u0633\u064a\u0631\u0648\u0645 \u0627\u0644\u0645\u0644\u062d\u064a\u0651\u0650 \u064a\u0648\u0645\u064a\u0651\u064e\u0627\u064b \u0644\u0645\u062f\u0651\u064e\u0629 7 \u0623\u064a\u0651\u064e\u0627\u0645\u064d (11)\u060c \u0628\u062d\u062c\u0645 10 ml\/kg\/day (12)<strong>.<\/strong><\/p>\n<p>\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629 Alendronate group (ALD): \u0646\u064f\u0628\u0651\u0650\u0628\u064e\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u0645\u0648\u064a\u0651\u064e\u0627\u064b \u0628\u0627\u0644\u0633\u064a\u0631\u0648\u0645 \u0627\u0644\u0645\u0644\u062d\u064a\u0651\u0650 \u064a\u0648\u0645\u064a\u0651\u064e\u0627\u064b \u0644\u0645\u062f\u0651\u064e\u0629\u0650 4 \u0623\u064a\u0651\u064e\u0627\u0645\u064d\u060c \u062b\u0645\u0651\u064e \u0646\u064f\u0628\u0651\u0650\u0628\u064e\u062a \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0631\u064e\u0651\u0627\u0628\u0639 \u0628\u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0628\u062c\u0631\u0639\u0629 20 mg\/kg\/day \u0644\u0645\u062f\u0651\u064e\u0629 4 \u0623\u064a\u0651\u064e\u0627\u0645\u060c \u0648\u0642\u062f \u062a\u064e\u0645\u0651\u064e \u0627\u062e\u062a\u064a\u0627\u0631 \u0647\u0630\u0647 \u0627\u0644\u062c\u0631\u0639\u0629 \u0628\u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u062f\u0631\u0627\u0633\u0627\u062a\u064d \u0633\u0627\u0628\u0642\u0629\u064d \u0623\u0643\u0651\u064e\u062f\u062a \u0623\u0646\u0651\u064e \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0644\u0644\u062c\u0631\u0630\u0627\u0646 \u0628\u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0633\u0651\u064e\u0627\u0628\u0642\u0629 \u064a\u0633\u0628\u0651\u0650\u0628\u064f \u0623\u0630\u064a\u0651\u064e\u0629\u064b \u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629\u064b \u0648\u0627\u0636\u062d\u0629\u064b (13)\u060c \u062a\u0639\u0627\u062f\u0644 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0625\u062d\u062f\u0627\u062b \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 20 \u0636\u0639\u0641\u064e \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0642\u0627\u0631\u0628\u0629 \u0644\u0647\u0627 \u0639\u0646\u062f \u0627\u0644\u0628\u0634\u0631 \u0648\u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629\u0650 \u0644\u0639\u0644\u0627\u062c \u0647\u0634\u0627\u0634\u0629 \u0627\u0644\u0639\u0638\u0627\u0645 (10 \u0645\u0644\u063a\/\u0627\u0644\u064a\u0648\u0645).<\/p>\n<p>\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 Alendronate+Atorvastatin group (ALD+ATO): \u062a\u0644\u0642\u0651\u064e\u062a \u0643\u0644\u0651\u064e\u0627\u064b \u0645\u0646 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0648\u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u064a\u0648\u0645\u064a\u064e\u0651\u0627\u064b\u060c \u062d\u064a\u062b \u0646\u064f\u0628\u0651\u0650\u0628\u064e\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0623\u0648\u0651\u064e\u0644\u0627\u064b \u0628\u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0628\u062c\u0631\u0639\u0629 10 mg\/kg\/day \u0644\u0645\u062f\u0651\u064e\u0629 7 \u0623\u064a\u0651\u064e\u0627\u0645\u064d \u0641\u0645\u0648\u064a\u0651\u064e\u0627\u064b (10)\u060c \u0648\u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0631\u0651\u064e\u0627\u0628\u0639 \u0628\u0639\u062f \u0627\u0644\u0627\u0646\u062a\u0638\u0627\u0631 \u0644\u0645\u062f\u0651\u064e\u0629\u0650 \u0633\u0627\u0639\u0629\u064d \u0646\u064f\u0628\u0651\u0650\u0628\u064e\u062a \u0628\u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0628\u062c\u0631\u0639\u0629 20 mg\/kg\/day \u0644\u0645\u062f\u0651\u064e\u0629 4 \u0623\u064a\u0651\u064e\u0627\u0645.<\/p>\n<p>\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 Atorvastatin group (ATO):<\/p>\n<p>\u0648\u0647\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062a\u064a \u062a\u0644\u0642\u0651\u064e\u062a \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0644\u0648\u062d\u062f\u0647\u060c \u062d\u064a\u062b \u0646\u064f\u0628\u0651\u0650\u0628\u064e\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 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\u064a\u0648\u0645\u064a\u0651\u064e\u0627\u064b \u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0623\u064a\u0651\u0650 \u062a\u0628\u062f\u064f\u0651\u0644\u064d \u0641\u064a \u062a\u0646\u0627\u0648\u0644\u0647\u0627 \u0644\u0644\u0637\u0639\u0627\u0645 \u0648\u0634\u0631\u0628\u0647\u0627 \u0644\u0644\u0645\u0627\u0621\u060c \u0648\u062a\u0645\u0651\u064e \u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0623\u0648\u0632\u0627\u0646 \u064a\u0648\u0645\u064a\u0651\u064e\u0627\u064b \u0645\u0650\u0646\u0652 \u0623\u062c\u0644 \u0645\u0631\u0627\u0642\u0628\u0629\u0650 \u062a\u063a\u064a\u0651\u064f\u0631 \u0627\u0644\u0648\u0632\u0646 \u0648\u062f\u0631\u0627\u0633\u0629\u0650 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u0623\u0648\u0632\u0627\u0646 \u0627\u0644\u062c\u0631\u0630\u0627\u0646 \u0641\u064a \u064a\u0648\u0645 \u0627\u0644\u062a\u0651\u064e\u0636\u062d\u064a\u0629 \u0648\u0628\u062f\u0627\u064a\u0629 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\u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0651\u064e\u0629 \u0645\u0639 \u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u062c\u0627\u0646\u0633\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0647\u064a\u0626\u0629 \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0651\u064e\u0629\u060c \u0648\u062a\u0645\u0651\u064e \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u062c\u064f\u0646\u0627\u0633\u0629\u064d \u0628\u062a\u0631\u0643\u064a\u0632 10%.<\/p>\n<p>\u0627\u0644\u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629:<\/p>\n<p>\u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u0623\u0648\u0632\u0627\u0646 \u0627\u0644\u062c\u0631\u0630\u0627\u0646 \u0641\u064a \u064a\u0648\u0645 \u0627\u0644\u062a\u0651\u064e\u0636\u062d\u064a\u0629 \u0648\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0623\u0648\u0651\u064e\u0644 \u0645\u0646 \u0627\u0644\u062a\u0651\u064e\u062c\u0631\u0628\u0629 Weight difference between the final and the first day:<\/p>\n<p>\u062a\u0645\u0651\u064e\u062a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0641\u0631\u0642 \u0628\u064a\u0646 \u0648\u0632\u0646 \u0627\u0644\u062c\u064f\u0631\u0652\u0630\u0650 \u0641\u064a \u064a\u0648\u0645 \u0627\u0644\u062a\u0651\u064e\u0636\u062d\u064a\u0629 \u0648\u0648\u0632\u0646\u0647 \u0641\u064a \u0628\u062f\u0627\u064a\u0629 \u0627\u0644\u062a\u0651\u064e\u062c\u0631\u0628\u0629 (\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0623\u0648\u064e\u0651\u0644 \u0641\u064a \u062a\u062c\u0631\u064a\u0639 \u0627\u0644\u062c\u0631\u0630\u0627\u0646) \u0643\u064e\u0645\u064e\u0639\u0644\u064e\u0645\u064d \u063a\u064a\u0631 \u0645\u0628\u0627\u0634\u0631\u064d \u0644\u0644\u0623\u0630\u064a\u0651\u064e\u0629\u0650 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629.<\/p>\n<p>\u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0639\u064e\u064a\u0627\u0646\u064a Macroscopic examination:<\/p>\n<p>\u062a\u0645\u0651\u064e \u062d\u0633\u0627\u0628 \u0645\u064e\u0646\u0652\u0633\u064e\u0628 \u0627\u0644\u0642\u0631\u062d\u0629 Ulcer Index \u0644\u0643\u0644\u0651\u0650 \u0645\u062c\u0645\u0648\u0639\u0629\u064d \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u0651\u064e\u0627\u0644\u064a\u0629 (15):<\/p>\n<p>\u0628\u0639\u062f \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0639\u062f\u062f \u0627\u0644\u0642\u0631\u062d\u0627\u062a \u0644\u0643\u0644\u0651\u0650 \u062c\u0631\u0630\u064d\u060c \u0648\u062d\u0633\u0627\u0628 \u0645\u062a\u0648\u0633\u0651\u064e\u0637 \u0639\u062f\u062f \u0627\u0644\u0642\u0631\u062d\u0627\u062a \u0644\u0644\u062c\u0631\u0630\u0627\u0646 (UN)\u060c \u062d\u064f\u0633\u0650\u0628\u064e\u062a \u062f\u0631\u062c\u0629 \u0627\u0644\u0634\u0651\u0650\u062f\u0651\u064e\u0629 \u0644\u0643\u0644\u0651\u0650 \u062c\u064f\u0631\u0652\u0630\u064d \u0628\u062c\u0645\u0639 \u0646\u0642\u0627\u0637 \u0627\u0644\u0645\u0639\u0627\u0644\u0645 \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0651\u064e\u0627\u0644\u064a\u060c \u0648\u062d\u064f\u0633\u0650\u0628\u064e \u0645\u062a\u0648\u0633\u0651\u0650\u0637 \u0634\u062f\u0651\u064e\u0629 \u0627\u0644\u0642\u0631\u062d\u0627\u062a \u0644\u0644\u062c\u0631\u0630\u0627\u0646 (US):<\/p>\n<p>0 = \u0645\u0639\u062f\u0629\u064c \u0628\u0644\u0648\u0646\u064d \u0637\u0628\u064a\u0639\u064a\u0651\u064d Normal colored stomach<\/p>\n<p>0.5 = \u0645\u0639\u062f\u0629\u064c \u0628\u0644\u0648\u0646\u064d \u0623\u062d\u0645\u0631\u064e Red coloration<\/p>\n<p>1.0 = \u0642\u0631\u062d\u0627\u062a\u064c \u0628\u0642\u0639\u064a\u0651\u064e\u0629\u064c Spot ulcer<\/p>\n<p>1.5 = \u0634\u0631\u0627\u0626\u0637\u064f \u0646\u0632\u0641\u064a\u0651\u064e\u0629\u064c Hemorrhagic streak<\/p>\n<p>2.0 = \u0642\u0631\u062d\u0627\u062a\u064c \u0639\u0645\u064a\u0642\u0629\u064c Deep ulcer<\/p>\n<p>3.0 = \u0627\u0646\u062b\u0642\u0627\u0628 Perforation<\/p>\n<p>Ulcer Index (UI) = UN + US + (UP\/10)<\/p>\n<p>(UP): \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u064e\u0629 \u0644\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0642\u0631\u062d\u0629.<\/p>\n<p>\u0641\u062d\u0635 \u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u062a\u0651\u064e\u0634\u0631\u064a\u062d \u0627\u0644\u0645\u0631\u0636\u064a Histopathological examination:<\/p>\n<p>\u062a\u0645\u0651\u064e\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0645\u062e\u0628\u0631 \u0627\u0644\u062a\u0651\u064e\u0634\u0631\u064a\u062d \u0627\u0644\u0645\u0631\u0636\u064a\u0651\u0650 \u0641\u064a \u0645\u0634\u0641\u0649 \u0627\u0644\u0623\u0633\u062f \u0627\u0644\u062c\u0627\u0645\u0639\u064a\u0651\u0650\u060c \u062d\u064a\u062b \u062c\u064f\u0641\u0651\u0650\u0641\u064e\u062a \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a\u064f \u0627\u0644\u0646\u0651\u064e\u0633\u064a\u062c\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u0648\u0636\u0648\u0639\u0629\u00a0 \u0641\u064a \u0627\u0644\u0641\u0648\u0631\u0645\u0648\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0625\u064a\u062a\u0627\u0646\u0648\u0644 \u0648\u062f\u064f\u0645\u0650\u062c\u064e\u062a \u0641\u064a \u0627\u0644\u0628\u0627\u0631\u0627\u0641\u064a\u0646\u060c \u062b\u0645\u0651\u064e \u0642\u064f\u0637\u0651\u0650\u0639\u064e\u062a \u0644\u0645\u0642\u0627\u0637\u0639\u064e \u0628\u0633\u0645\u0627\u0643\u0629 5 \u00b5m\u060c \u0648\u0644\u0648\u0651\u0650\u0646\u062a \u0628\u0627\u0644\u0647\u064a\u0645\u0627\u062a\u0648\u0643\u0633\u064a\u0644\u064a\u0646 \u0648\u0627\u0644\u0625\u064a\u0648\u0632\u064a\u0646\u061b \u0644\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0651\u0650 \u062a\u062d\u062a \u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0636\u0648\u0626\u064a\u0651\u0650 (16).<\/p>\n<p>\u062a\u0645\u0651\u064e \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0645\u0642\u0627\u0637\u0639 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0634\u0651\u064e\u0631\u0627\u0626\u062d \u0627\u0644\u0645\u062c\u0647\u0631\u064a\u0651\u064e\u0629 \u062a\u062d\u062a \u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0636\u0651\u064e\u0648\u0626\u064a \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0645\u0648\u0636\u0651\u064e\u062d\u0629 \u0641\u064a \u0627\u0644\u0623\u062f\u0628\u064a\u0651\u064e\u0627\u062a \u0645\u0650\u0646\u0652 \u0642\u0628\u0644\u064f\u060c \u062d\u064a\u062b \u062a\u0645\u0651\u064e \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u062a\u0651\u064e\u0627\u0644\u064a\u0629\u060c \u0648\u0647\u064a: \u062e\u0633\u0627\u0631\u0629\u064f \u0627\u0644\u0638\u0651\u064e\u0647\u0627\u0631\u0629 \u0627\u0644\u0633\u0651\u064e\u0637\u062d\u064a\u0651\u064e\u0629\u060c \u0648\u0627\u0644\u0646\u0651\u064e\u0632\u0641\u064f\u060c \u0648\u0627\u062d\u062a\u0642\u0627\u0646\u064f \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629\u060c \u0648\u0623\u0630\u064a\u0651\u064e\u0629\u064f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u063a\u062f\u064a\u0651\u064e\u0629\u060c \u0648\u0627\u0631\u062a\u0634\u0627\u062d\u064f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651\u064e\u0629. \u062f\u0631\u062c\u0629\u064b \u0646\u0633\u064a\u062c\u064a\u0651\u064e\u0629\u064b \u0645\u064e\u0631\u064e\u0636\u0650\u064a\u0651\u064e\u0629\u064b \u0639\u0644\u0649 \u0627\u0644\u0646\u0651\u062d\u0648 \u0627\u0644\u062a\u0651\u0627\u0644\u064a: 0: \u0644\u0627 \u064a\u0648\u062c\u062f\u060c 1: \u062e\u0641\u064a\u0641\u064c\u060c 2: \u0645\u062a\u0648\u0633\u0651\u0650\u0637\u064c\u060c 3: \u0634\u062f\u064a\u062f\u064c (17).<\/p>\n<p>\u0645\u0639\u0627\u064a\u0631\u0629 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0645\u0627\u0644\u0648\u0646 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0623\u0644\u062f\u0647\u064a\u062f Malondialdehyde (MDA) assay:<\/p>\n<p>\u0645\u0628\u062f\u0623 \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629: \u064a\u064f\u0639\u064e\u062f\u0651\u064f \u0627\u0644\u0645\u0627\u0644\u0648\u0646 \u062b\u0646\u0627\u0626\u064a\u0651\u0650 \u0627\u0644\u0623\u0644\u062f\u0647\u064a\u062f MDA \u0623\u062d\u062f\u064e \u0646\u0648\u0627\u062a\u062c \u0641\u0648\u0642 \u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0644\u064a\u0628\u064a\u062f\u0627\u062a lipid peroxidation\u060c \u0648\u064a\u0645\u062b\u0651\u0650\u0644\u064f \u0627\u0644\u0642\u064a\u0627\u0633\u064f \u0627\u0644\u0643\u0645\u064a\u0651\u064f \u0644\u0640 MDA \u0645\u0624\u0634\u0651\u0650\u0631\u0627\u064b \u062c\u064a\u0651\u0650\u062f\u0627\u064b \u0644\u0641\u0639\u0627\u0644\u064a\u0651\u064e\u0629 \u0641\u0648\u0642 \u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0644\u064a\u0628\u064a\u062f\u0627\u062a\u060c \u0648\u064a\u062a\u0645\u0651\u064f \u0627\u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u0643\u0645\u0651\u0650\u064a\u0651\u064f \u0639\u0628\u0631 \u0627\u0644\u062a\u0651\u064e\u0641\u0627\u0639\u0644 \u0627\u0644\u0644\u0648\u0646\u064a\u0651\u0650 \u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u062a\u064a\u0648\u0628\u0627\u0631\u0628\u064a\u062a\u0648\u0631\u064a TBA (18).<\/p>\n<p>\u0628\u0627\u062e\u062a\u0635\u0627\u0631\u064d\u060c \u062a\u0645\u0651\u064e \u0645\u0632\u062c 0.5 \u0645\u0644 \u0645\u0650\u0646\u064e \u0627\u0644\u062c\u064f\u0646\u0627\u0633\u0629 \u0627\u0644\u0646\u0651\u064e\u0633\u064a\u062c\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 (10%) \u0645\u0639 2 \u0645\u0644 \u0645\u0650\u0646\u064e \u0627\u0644\u0643\u0627\u0634\u0641 \u0627\u0644\u0645\u0643\u0648\u0651\u064e\u0646\u0650 \u0645\u0650\u0646\u0652 \u062d\u0645\u0636\u0650 \u0627\u0644\u062e\u0644\u0651\u0650 \u0645\u062b\u0644\u062b \u0627\u0644\u0643\u0644\u0648\u0631 TCA (15% w\/v)\u060c \u0648\u062d\u0645\u0636\u0650 \u0627\u0644\u062a\u064a\u0648\u0628\u0627\u0631\u0628\u064a\u062a\u0648\u0631\u064a TBA (0.375% w\/v)\u060c \u0648\u062d\u0645\u0636\u0650 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 HCl (0.25N)\u060c \u0648\u0645\u0650\u0646\u0652 \u062b\u064e\u0645\u0651\u064e \u0633\u064f\u062e\u0651\u0650\u0646\u064e \u0627\u0644\u0645\u0632\u064a\u062c\u064f \u0641\u064a \u062d\u0645\u0651\u064e\u0627\u0645\u064d \u0645\u0627\u0626\u064a\u0651\u064d \u063a\u0627\u0644\u064a \u0644\u0645\u062f\u0651\u064e\u0629 15 \u062f\u0642\u064a\u0642\u0629\u064d\u060c \u0628\u0639\u062f \u0630\u0644\u0643 \u062a\u0645\u0651\u064e \u062a\u0628\u0631\u064a\u062f\u064f\u0647\u064f \u0648\u062a\u062b\u0641\u064a\u0644\u064f\u0647\u064f\u060c \u062a\u0645\u0651\u064e\u062a \u0642\u0631\u0627\u0621\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0633\u0651\u064e\u0627\u0626\u0644 \u0627\u0644\u0637\u0651\u064e\u0627\u0641\u064a \u0644\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0628\u064a\u0643\u062a\u0631\u0648\u0641\u0648\u062a\u0648\u0645\u062a\u0631 \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 (532 nm) (19).<\/p>\n<p>\u0648\u0645\u0646 \u062b\u064e\u0645\u0651\u064e \u062a\u064e\u0645\u0651\u064e \u062d\u0633\u0627\u0628 \u062a\u0631\u0643\u064a\u0632 MDA \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0645\u0648\u0644\u0627\u0631\u064a (1.56 \u00d7 10<sup>5<\/sup> M<sup>-1<\/sup> cm<sup>-1<\/sup>) \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u0639\u0627\u062f\u0644\u0629 \u0627\u0644\u062a\u0651\u064e\u0627\u0644\u064a\u0629 (20,21):<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1975\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/Capture-1-300x35.png\" alt=\"\" width=\"377\" height=\"44\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/Capture-1-300x35.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/Capture-1.png 405w\" sizes=\"auto, (max-width: 377px) 100vw, 377px\" \/><\/p>\n<p>\u062d\u064a\u062b:<\/p>\n<p>A: \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635\u064a\u064e\u0651\u0629\u064f.<\/p>\n<p>10<sup>8<\/sup>: \u0646\u0627\u062a\u062c\u0629\u064c \u0639\u0646 10<sup>6<\/sup> (\u062a\u062d\u0648\u064a\u0644 M \u0625\u0644\u0649 \u00b5M) \u00d7 10<sup>2<\/sup> (\u0636\u0631\u0628 \u0627\u0644\u0628\u0633\u0637 \u0648\u0627\u0644\u0645\u0642\u0627\u0645 \u0628\u0640 10<sup>2<\/sup> \u0644\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0648\u0627\u062d\u062f\u0629 \u0628\u0640 100 g \u0645\u0646 \u0627\u0644\u0646\u0633\u064a\u062c).<\/p>\n<p>\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0629 Statistical analysis:<\/p>\n<p>\u0627\u0633\u062a\u064f\u062e\u062f\u0650\u0645\u064e \u0627\u0644\u0645\u062a\u0648\u0633\u0651\u0650\u0637\u064f \u00b1 \u0627\u0644\u062e\u0637\u0623 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0644\u0645\u062a\u0648\u0633\u0651\u0650\u0637 Mean \u00b1 S.E.M \u0644\u0644\u062a\u0651\u064e\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0646\u0651\u064e\u062a\u0627\u0626\u062c\u060c \u0648\u062a\u0645\u0651\u064e \u0627\u0639\u062a\u0628\u0627\u0631 \u0623\u0646\u0651\u064e \u0627\u0644\u0641\u0627\u0631\u0642 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e \u0628\u064a\u0646 \u0627\u0644\u0645\u062a\u0648\u0633\u0651\u0650\u0637\u0627\u062a \u0645\u0639\u062a\u062f\u064e\u0651\u0627\u064b \u0628\u0647 \u0639\u0646\u062f\u0645\u0627 \u062a\u0643\u0648\u0646 \u0642\u064a\u0645\u0629 p-value \u0623\u0642\u0644\u0651\u064e \u0645\u0650\u0646\u0652 0.05 (p&lt; 0.05)\u060c \u062d\u064a\u062b \u0623\u062c\u064f\u0631\u0650\u064a\u064e\u062a\u0652 \u0627\u0644\u062f\u0651\u0650\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c SPSS version 26 for windows\u060c \u0648\u0627\u062e\u062a\u064a\u0627\u0631 One-Way ANOVA \u0645\u062a\u0628\u0648\u0639\u0627\u064b \u0628\u0627\u062e\u062a\u0628\u0627\u0631 post Hoc Dunnett T3 \u0644\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u0651\u064e\u062a\u064a \u0644\u0647\u0627 \u062a\u0628\u0627\u064a\u0646\u0627\u062a\u064c \u0645\u062e\u062a\u0644\u0641\u0629\u064c non-equal variances\u060c \u0648\u0627\u062e\u062a\u0628\u0627\u0631 Sidak \u0644\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u062a\u064a \u0644\u0647\u0627 \u062a\u0628\u0627\u064a\u0646\u0627\u062a\u064c \u0645\u062a\u0633\u0627\u0648\u064a\u0629\u064c equal variances.<\/p>\n<p>\u0627\u0644\u0646\u062a\u0627\u0626\u062c Results<\/p>\n<p>\u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u0623\u0648\u0632\u0627\u0646 \u0627\u0644\u062c\u0631\u0630\u0627\u0646 \u0641\u064a \u064a\u0648\u0645 \u0627\u0644\u062a\u0651\u064e\u0636\u062d\u064a\u0629 \u0648\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0623\u0648\u064e\u0651\u0644 \u0645\u0646 \u0627\u0644\u062a\u0651\u064e\u062c\u0631\u0628\u0629:<\/p>\n<p>\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u0651\u064e\u062a\u0627\u0626\u062c \u0623\u0646\u0651\u064e \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0642\u062f \u0623\u062f\u0651\u064e\u0649 \u0625\u0644\u0649 \u062d\u062f\u0648\u062b \u0646\u0642\u0635\u0627\u0646\u064d \u0648\u0627\u0636\u062d\u064d \u0630\u064a \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0629\u064d (p\u02c20.05) \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629 (ALD) (-13.12 \u00b1 3.34 g) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 (NC) (3.42 \u00b1 4.29 g).<\/p>\n<p>\u0644\u0643\u0646 \u0644\u0645 \u064a\u0624\u062f\u0651\u0650 \u0625\u0639\u0637\u0627\u0621 \u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0625\u0644\u0649 \u062a\u062d\u0633\u0651\u064f\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 (ALD+ATO) (-13.65 \u00b1 2.26g) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629\u00a0 (ALD) (-13.12 \u00b1 3.34 g)\u060c \u0645\u0639 \u0645\u0644\u0627\u062d\u0638\u0629 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642\u064d \u0630\u064a \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0629\u064d (p\u02c20.05) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 (NC).<\/p>\n<p>\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0645\u0647\u0645\u0651\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0644\u0648\u062d\u062f\u0647 (ATO) \u062d\u064a\u062b \u0643\u0627\u0646 \u0627\u0644\u0641\u0631\u0642 \u0641\u064a \u0627\u0644\u0648\u0632\u0646 (1.12 \u00b1 5.2 g) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 (NC) (3.42 \u00b1 4.29 g) (\u0627\u0644\u0645\u062e\u0637\u0637 1).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1977 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/1-3-300x181.png\" alt=\"\" width=\"502\" height=\"303\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/1-3-300x181.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/1-3.png 546w\" sizes=\"auto, (max-width: 502px) 100vw, 502px\" \/><\/p>\n<p><strong>\u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0639\u064e\u064a\u0627\u0646\u064a\u0651\u0650 <\/strong><strong>Macroscopic examination<\/strong>:<\/p>\n<p>\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u0651\u064e\u062a\u0627\u0626\u062c \u0644\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629\u064b \u0633\u0644\u064a\u0645\u0629\u064b \u0641\u064a \u0645\u0639\u0638\u0645 \u0639\u064a\u0651\u0650\u0646\u0627\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 \u0645\u0639 \u0628\u0639\u0636 \u0627\u0644\u0646\u0651\u064f\u0632\u0648\u0641\u0627\u062a \u0627\u0644\u0646\u0642\u0637\u064a\u0651\u064e\u0629 \u0627\u0644\u0635\u0651\u064e\u063a\u064a\u0631\u0629 (\u0627\u0644\u0634\u0643\u0644 1 \u0627\u0644\u0635\u0648\u0631\u0629 A)\u060c \u0623\u062f\u0651\u064e\u0649 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0625\u0644\u0649 \u062a\u0642\u0631\u0651\u064f\u062d\u0650 \u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u0639\u062f\u0629 \u0641\u064a \u0643\u0644\u0651\u0650 \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a \u0627\u0644\u0645\u0641\u062d\u0648\u0635\u0629\u060c \u062d\u064a\u062b \u062a\u0638\u0627\u0647\u0631\u062a \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629\u064f \u0628\u0627\u0644\u0628\u0642\u0639 \u0627\u0644\u0646\u0642\u0637\u064a\u0651\u064e\u0629 \u0648\u0627\u0644\u0634\u0651\u064e\u0631\u0627\u0626\u0637 \u0627\u0644\u0646\u0632\u0641\u064a\u0651\u064e\u0629 \u0648\u0627\u0644\u0627\u062d\u0645\u0631\u0627\u0631 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a (\u0627\u0644\u0634\u0643\u0644 1 \u0627\u0644\u0635\u0648\u0631\u0629 B)\u060c \u062d\u064a\u062b \u0648\u062c\u062f \u0641\u0627\u0631\u0642\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064c (p\u02c20.05) \u0641\u064a \u0645\u064e\u0646\u0652\u0633\u064e\u0628 \u0627\u0644\u0642\u0631\u062d\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629 (ALD) (17.25 \u00b1 1.51) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 (NC) (11.16 \u00b1 0.65).<\/p>\n<p>\u0623\u062f\u0651\u064e\u0649 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0625\u0644\u0649 \u062a\u062d\u0633\u0651\u064f\u0646 \u0645\u0638\u0647\u0631 \u0627\u0644\u0645\u0639\u062f\u0629 \u062d\u064a\u062b\u064f \u0628\u062f\u062a \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629\u064f \u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629\u064b \u0641\u064a \u0623\u063a\u0644\u0628 \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a (\u0627\u0644\u0634\u0643\u0644 1 \u0627\u0644\u0635\u0648\u0631\u0629 C)\u060c \u0648\u0648\u062c\u0650\u062f\u064e \u0641\u0627\u0631\u0642\u064c \u0630\u0648 \u062f\u0644\u0627\u0644\u0629\u064b \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0629\u064d \u0647\u0627\u0645\u0651\u064e\u0629\u064d (p\u02c20.01) \u0641\u064a \u0645\u064e\u0646\u0652\u0633\u064e\u0628 \u0627\u0644\u0642\u0631\u062d\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 (ALD+ATO) (10.56 \u00b1 1.64) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629(17.25 \u00b1 1.51) (ALD) \u060c \u0648\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0645\u0647\u0645\u0651\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 (NC).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1978 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/2-2-300x126.png\" alt=\"\" width=\"524\" height=\"220\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/2-2-300x126.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/2-2.png 738w\" sizes=\"auto, (max-width: 524px) 100vw, 524px\" \/><\/p>\n<p>\u0628\u0627\u0644\u0646\u0651\u0650\u0633\u0628\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0644\u0648\u062d\u062f\u0647 (ATO) \u0643\u0627\u0646\u062a \u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629\u064f \u0627\u0644\u0645\u0639\u062f\u0629 \u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629\u064b \u0641\u064a \u0623\u063a\u0644\u0628 \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a (\u0627\u0644\u0634\u0643\u0644 1 \u0627\u0644\u0635\u0648\u0631\u0629 D) \u0648\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0645\u0647\u0645\u0651\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0641\u064a \u0645\u064e\u0646\u0652\u0633\u064e\u0628 \u0627\u0644\u0642\u0631\u062d\u0629 (9.41 \u00b1 1.15) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 (NC) (11.16 \u00b1 0.65) (\u0627\u0644\u0645\u062e\u0637\u0637 2) .<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1979 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/3-2-300x206.png\" alt=\"\" width=\"408\" height=\"280\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/3-2-300x206.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/3-2.png 514w\" sizes=\"auto, (max-width: 408px) 100vw, 408px\" \/><\/p>\n<p><strong>\u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u062a\u0634\u0631\u064a\u062d \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u0650 Histopathological examination:<\/strong><\/p>\n<p>\u0623\u0638\u0647\u0631\u062a \u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u0639\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 (NC) \u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629\u064b \u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629\u064b \u0645\u0639 \u0648\u062c\u0648\u062f \u0627\u062d\u062a\u0642\u0627\u0646\u064d \u0648\u0639\u0627\u0626\u064a\u0651\u064d \u0648\u0646\u0632\u0641\u064d \u062e\u0641\u064a\u0641\u064d \u0648\u062e\u0633\u0627\u0631\u0629\u064d \u062e\u0641\u064a\u0641\u0629\u064d \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0651\u064e\u0629 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a (\u0627\u0644\u0634\u0643\u0644 2).<\/p>\n<p>\u0623\u062f\u0651\u064e\u0649 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629 (ALD) \u0625\u0644\u0649 \u062d\u062f\u0648\u062b \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 \u0641\u064a \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0648\u0627\u0644\u0642\u0631\u062d\u0627\u062a \u0641\u064a \u0643\u0644\u0651\u0650 \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a\u060c \u062d\u064a\u062b \u0623\u0628\u062f\u062a \u0645\u0639\u0638\u0645\u064f \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a \u0627\u062d\u062a\u0642\u0627\u0646\u0627\u064b \u0648\u0639\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0648\u0646\u0632\u0641\u0627\u064b \u0641\u064a \u0627\u0644\u0637\u0628\u0642\u062a\u064a\u0646 \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0648\u062a\u062d\u062a\u064e \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0628\u0641\u0627\u0631\u0642\u064d \u0647\u0627\u0645\u0651\u064d \u062c\u062f\u0651\u064e\u0627\u064b \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b (p\u02c20.001) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 (NC) (\u0627\u0644\u0645\u062e\u0637\u0637 3\u060c \u0648\u0627\u0644\u0645\u062e\u0637\u0637 4)\u060c \u0648\u0627\u0631\u062a\u0634\u0627\u062d\u0627\u064b \u0634\u062f\u064a\u062f\u0627\u064b \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651\u064e\u0629 \u0648\u062e\u0627\u0635\u0651\u064e\u0629\u064b \u0627\u0644\u0639\u062f\u0644\u0627\u062a \u0645\u0639 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064d \u0647\u0627\u0645\u0651\u064d (p\u02c20.01) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 (\u0627\u0644\u0645\u062e\u0637\u0637 5)\u060c \u0625\u0636\u0627\u0641\u0629\u064b \u0625\u0644\u0649 \u0627\u0644\u062a\u0648\u0633\u0651\u064f\u0639 \u0641\u064a \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0645\u0639 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064d \u0647\u0627\u0645\u0651\u064d (p\u02c20.01) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 (\u0627\u0644\u0645\u062e\u0637\u0637 6)\u060c \u0648\u0627\u0644\u062e\u0633\u0627\u0631\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0651\u064e\u0629 \u062d\u064a\u062b \u0648\u062c\u062f \u0641\u0627\u0631\u0642\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064c (p\u02c20.05) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 (\u0627\u0644\u0645\u062e\u0637\u0637 7) (\u0627\u0644\u0634\u0643\u0644 3).<\/p>\n<p>\u0641\u064a \u062d\u064a\u0646 \u0623\u062f\u0651\u064e\u0649 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0625\u0644\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 (ALD+ATO) \u0625\u0644\u0649 \u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0627\u062a \u0627\u0644\u0646\u0651\u064e\u0633\u064a\u062c\u064a\u0651\u064e\u0629 \u062c\u0645\u064a\u0639\u0647\u0627\u060c \u062d\u064a\u062b \u0638\u0647\u0631\u062a \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629\u064f \u0633\u0644\u064a\u0645\u0629\u064b \u0628\u0627\u0633\u062a\u062b\u0646\u0627\u0621 \u0628\u0639\u0636 \u0627\u0644\u0646\u0651\u064f\u0632\u0648\u0641\u0627\u062a \u0627\u0644\u062e\u0641\u064a\u0641\u0629 \u0648\u0627\u0644\u062e\u0633\u0627\u0631\u0629 \u0627\u0644\u062e\u0641\u064a\u0641\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0651\u064e\u0629 \u0648\u0627\u0644\u0627\u0631\u062a\u0634\u0627\u062d \u0627\u0644\u062e\u0641\u064a\u0641 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651\u064e\u0629 (\u0627\u0644\u0634\u0643\u0644 4\u060c \u0627\u0644\u0635\u0648\u0631\u0629 G)\u060c \u062d\u064a\u062b \u0648\u062c\u062f \u0641\u0627\u0631\u0642\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064c \u0647\u0627\u0645\u0651\u064c (p\u02c20.01) \u0641\u064a \u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u062a\u0645\u062b\u0651\u0650\u0644\u0629 \u0628\u0627\u0631\u062a\u0634\u0627\u062d \u0627\u0644\u0639\u062f\u0644\u0627\u062a (\u0627\u0644\u0645\u062e\u0637\u0637 5)\u060c \u0648\u0641\u0627\u0631\u0642\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064d (p\u02c20.05) \u0641\u064a \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u062a\u0645\u062b\u0651\u0650\u0644\u0629 \u0628\u0627\u062d\u062a\u0642\u0627\u0646 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0651\u064e\u0629\u060c \u0648\u0627\u0644\u0646\u0632\u0641\u060c \u0648\u062a\u0648\u0633\u0651\u064f\u0639 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629\u060c \u0648\u062e\u0633\u0627\u0631\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0651\u064e\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 (ALD+ATO) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629 (ALD) \u0627\u0644\u0645\u062e\u0637\u0637\u0627\u062a (3\u060c \u06484\u060c \u06486\u060c \u06487 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628)\u060c \u0648\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064c \u0641\u064a \u0623\u064a\u0651\u0650 \u062f\u0631\u062c\u0629 \u0623\u0630\u064a\u0651\u064e\u0629\u064d \u0646\u0633\u064a\u062c\u064a\u0651\u064e\u0629\u064d \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 (NC).<\/p>\n<p>\u0623\u0645\u0651\u064e\u0627 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0644\u0648\u062d\u062f\u0647\u0627 (ATO) \u0641\u0642\u062f \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 \u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629\u064b \u0645\u0639 \u0648\u062c\u0648\u062f \u0627\u062d\u062a\u0642\u0627\u0646\u064d \u0648\u0639\u0627\u0626\u064a\u0651\u064d \u0648\u0646\u0632\u0641\u064d \u062e\u0641\u064a\u0641\u064d \u0648\u062e\u0633\u0627\u0631\u0629\u064d \u062e\u0641\u064a\u0641\u0629\u064d \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0651\u064e\u0629 \u0648\u0627\u0631\u062a\u0634\u0627\u062d\u064d \u062e\u0641\u064a\u0641\u064d \u0644\u0644\u0639\u062f\u0644\u0627\u062a \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0639\u064a\u0651\u0650\u0646\u0627\u062a (\u0627\u0644\u0634\u0643\u0644 4\u060c \u0627\u0644\u0635\u0648\u0631\u0629 H)\u060c \u0648\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0645\u0647\u0645\u0651\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0641\u064a \u0623\u064a\u0651\u0650 \u062f\u0631\u062c\u0629\u0650 \u0623\u0630\u064a\u0651\u064e\u0629\u064d \u0646\u0633\u064a\u062c\u064a\u0651\u064e\u0629\u064d \u0645\u0642\u0627\u0631\u0646\u0629\u064d \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1980 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/4-2-300x166.png\" alt=\"\" width=\"486\" height=\"269\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/4-2-300x166.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/4-2.png 674w\" sizes=\"auto, (max-width: 486px) 100vw, 486px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1981 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/5-2-300x259.png\" alt=\"\" width=\"434\" height=\"375\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/5-2-300x259.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/5-2.png 652w\" sizes=\"auto, (max-width: 434px) 100vw, 434px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1982 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/6-2-300x167.png\" alt=\"\" width=\"467\" height=\"260\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/6-2-300x167.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/6-2.png 622w\" sizes=\"auto, (max-width: 467px) 100vw, 467px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1983\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/7-1-300x257.png\" alt=\"\" width=\"404\" height=\"346\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/7-1-300x257.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/7-1.png 381w\" sizes=\"auto, (max-width: 404px) 100vw, 404px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1984\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/8-1-300x253.png\" alt=\"\" width=\"425\" height=\"358\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/8-1-300x253.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/8-1.png 392w\" sizes=\"auto, (max-width: 425px) 100vw, 425px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1985\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/9-1-294x300.png\" alt=\"\" width=\"393\" height=\"401\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/9-1-294x300.png 294w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/9-1.png 372w\" sizes=\"auto, (max-width: 393px) 100vw, 393px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1986\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/10-1-300x280.png\" alt=\"\" width=\"413\" height=\"385\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/10-1-300x280.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/10-1.png 396w\" sizes=\"auto, (max-width: 413px) 100vw, 413px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1987\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/11-1-300x269.png\" alt=\"\" width=\"397\" height=\"356\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/11-1-300x269.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/11-1.png 391w\" sizes=\"auto, (max-width: 397px) 100vw, 397px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0645\u0639\u0627\u064a\u0631\u0629 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0645\u0627\u0644\u0648\u0646 \u062b\u0646\u0627\u0626\u064a\u0651\u0650 \u0627\u0644\u0623\u0644\u062f\u0647\u064a\u062f Malondialdehyde (MDA) assay:<\/strong><br \/>\n\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u0651\u064e\u062a\u0627\u0626\u062c \u0623\u0646\u0651\u064e \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0642\u062f \u0633\u0628\u0651\u064e\u0628\u064e \u0627\u0631\u062a\u0641\u0627\u0639\u0627\u064b \u0630\u0627 \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0629\u064d \u0647\u0627\u0645\u0651\u064e\u0629\u064d (p\u02c20.01) \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a MDA \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629 (ALD) (113.92 \u00b1 6.20 \u03bcM\/100g) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 (NC) (69.12 \u00b1 8.92 \u03bcM\/100g).<br \/>\n\u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u0651\u064e\u062a\u0627\u0626\u062c \u0627\u0646\u062e\u0641\u0627\u0636\u0627\u064b \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a MDA \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 ((ALD+ATO (95.42 \u00b1 8.42 \u03bcM\/100g)\u060c \u0648\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0645\u0647\u0645\u0651\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u064e\u0631\u064e\u0636\u064a\u0651\u064e\u0629 (ALD) \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0645\u0633\u062a\u0648\u064a\u0627\u062a MDA (113.92 \u00b1 6.20 \u03bcM\/100g)\u060c \u0648\u0643\u0630\u0644\u0643 \u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0645\u0647\u0645\u0651\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u064e\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 (NC).<br \/>\n\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0644\u0648\u062d\u062f\u0647 (ATO) \u0643\u0627\u0646\u062a \u0645\u0633\u062a\u0648\u064a\u0627\u062a MDA (68.68 \u00b1 5.93 \u03bcM\/100g)\u060c \u0648\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0627\u0631\u0642\u064c \u0645\u0647\u0645\u0651\u064c \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u064e\u0627\u064b \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u064e\u0629 (NC) \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0645\u0633\u062a\u0648\u064a\u0627\u062a MDA (69.12 \u00b1 8.92 \u03bcM\/100g) (\u0627\u0644\u0645\u062e\u0637\u0637 8).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1988 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/12-1-300x275.png\" alt=\"\" width=\"375\" height=\"344\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/12-1-300x275.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/04\/12-1.png 370w\" sizes=\"auto, (max-width: 375px) 100vw, 375px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 Discussion<\/strong><\/p>\n<p>\u062a\u0646\u062a\u0645\u064aAlendronate \u00a0(ALD) \u0625\u0644\u0649 \u0632\u0645\u0631\u0629 \u0627\u0644\u0628\u064a\u0633\u0641\u0648\u0633\u0641\u0648\u0646\u0627\u062a \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0646\u062a\u0631\u0648\u062c\u064a\u0646 (N-BPs) \u0648\u0647\u064a \u0641\u0626\u0629\u064c \u0645\u0650\u0646\u064e \u0627\u0644\u0645\u0631\u0643\u0651\u064e\u0628\u0627\u062a \u0627\u0644\u0651\u064e\u062a\u064a \u062a\u0645\u0651\u064e \u062a\u0637\u0648\u064a\u0631\u0647\u0627 \u0643\u0639\u0648\u0627\u0645\u0644\u064e \u0645\u0636\u0627\u062f\u0651\u064e\u0629\u064d \u0644\u0644\u0627\u0631\u062a\u0634\u0627\u0641 \u0642\u0627\u062f\u0631\u0629\u064d \u0639\u0644\u0649 \u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0625\u0639\u0627\u062f\u0629 \u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0639\u0638\u0627\u0645\u060c \u0648\u0644\u0643\u0646 \u062a\u0645\u0651\u064e \u0627\u0644\u0625\u0628\u0644\u0627\u063a \u0623\u0646\u0651\u064e \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0647\u0627 \u062a\u0623\u062b\u064a\u0631\u0627\u062a\u064c \u063a\u064a\u0631\u064f \u0645\u0631\u063a\u0648\u0628\u064d \u0641\u064a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u0633\u0651\u064e\u0628\u064a\u0644 \u0627\u0644\u0647\u0636\u0645\u064a\u0651\u0650 \u0627\u0644\u0639\u0644\u0648\u064a\u0651\u0650 \u0644\u062f\u0649 \u0627\u0644\u0628\u0634\u0631\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064f \u0627\u0644\u0645\u0631\u064a\u0626\u064a\u0651\u064f \u0648\u0627\u0644\u0642\u0631\u062d\u0627\u062a (22).<\/p>\n<p>\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0650\u0651\u0631\u0627\u0633\u0627\u062a \u0623\u0646\u0651\u064e \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0648\u0627\u0644\u0634\u0651\u0650\u062f\u0651\u064e\u0629 \u0627\u0644\u062a\u0651\u064e\u0623\u0643\u0633\u062f\u064a\u0651\u064e\u0629 \u064a\u064f\u0639\u062f\u0651\u064e\u0627\u0646 \u0645\u0650\u0646\u0652 \u0623\u0647\u0645\u0651\u0650 \u0627\u0644\u0622\u0644\u064a\u0651\u064e\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0624\u062f\u0651\u0650\u064a \u0644\u0625\u062d\u062f\u0627\u062b \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0627\u0644\u0646\u0651\u064e\u0627\u062c\u0645\u0629 \u0639\u0646\u00a0\u00a0 ALD\u00a0 (13,23)\u060c \u0644\u0630\u0644\u0643 \u0641\u0642\u062f \u0631\u0643\u0651\u064e\u0632\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0651\u0650\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u064a \u062c\u0631\u062a \u0639\u0644\u0649 \u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0651\u064e\u062c\u0631\u0628\u0629 \u0639\u0644\u0649 \u0623\u0647\u0645\u064a\u0651\u064e\u0629 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0645\u0631\u0643\u0651\u064e\u0628\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0645\u062a\u0644\u0643 \u062e\u0635\u0627\u0626\u0635\u064e \u0645\u0636\u0627\u062f\u0651\u064e\u0629\u064b \u0644\u0644\u0623\u0643\u0633\u062f\u0629 \u0643\u0625\u062c\u0631\u0627\u0621\u064d \u0648\u0642\u0627\u0626\u064a\u0651\u064d \u0636\u062f\u0651\u064e \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0627\u0644\u0646\u0651\u064e\u0627\u062c\u0645\u0629 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\u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0623\u0646\u0651\u064e N-BPs \u062a\u0633\u0628\u0651\u064f\u0628 \u0623\u0630\u064a\u0651\u064e\u0629\u064b \u0641\u064a \u0627\u0644\u0645\u0639\u062f\u0629 \u0645\u0650\u0646\u0652 \u062e\u0644\u0627\u0644 \u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0627\u0644\u0645\u062e\u0631\u0651\u0634 \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0651\u0650\u060c \u0648\u0627\u0644\u0630\u064a \u062a\u0645\u062b\u0651\u064e\u0644\u062a \u0628\u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u0631\u0642 \u0627\u0644\u0643\u0645\u0648\u0646 \u0639\u0628\u0631 \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u0650 \u0644\u0644\u0645\u0639\u062f\u0629 (PD) transmucosal potential difference\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u064f\u0639\u062f\u0651\u064e \u0645\u0624\u0634\u0651\u0650\u0631\u0627\u064b \u0639\u0644\u0649 \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0645\u062e\u0627\u0637\u064a\u0651\u064e\u0629 (22).<\/p>\n<p>\u0643\u0645\u0627 \u0627\u0642\u062a\u0631\u062d\u062a Silva \u0648\u0632\u0645\u0644\u0627\u0624\u0647\u0627 (2014) \u0623\u0646\u0651\u064e \u0627\u0644\u0628\u064a\u0633\u0641\u0648\u0633\u0641\u0648\u0646\u0627\u062a \u0642\u062f \u062a\u0633\u0628\u0651\u0650\u0628\u064f \u0623\u0630\u064a\u0651\u064e\u0629\u064e \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a\u0651\u0650 \u0645\u0650\u0646\u0652 \u062e\u0644\u0627\u0644 \u062a\u0642\u0644\u064a\u0644 \u0625\u0646\u062a\u0627\u062c NO \u0645\u0646 \u0642\u0650\u0628\u064e\u0644 \u0645\u064f\u0635\u0646\u0651\u0650\u0639\u0629 \u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062a\u0651\u064e\u062f\u062e\u0651\u064f\u0644 \u0641\u064a \u0647\u062c\u0631\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0625\u0644\u0649 \u0645\u0648\u0627\u0642\u0639\u0650 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\u0623\u062e\u0631\u0649 \u063a\u064a\u0631 \u0627\u0644\u062a\u0651\u064e\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0651\u064e\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a Conclusions<\/strong><\/p>\n<p>\u0644\u0642\u062f \u0623\u0643\u0651\u064e\u062f\u0646\u0627 \u0645\u0650\u0646\u0652 \u062e\u0644\u0627\u0644 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0623\u0646\u0651\u064e \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u064a\u0633\u0628\u0651\u0650\u0628\u064f \u062d\u062f\u0648\u062b\u064e \u0623\u0630\u064a\u0651\u064e\u0629\u064d \u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629\u064d \u0639\u0646\u062f\u0645\u0627 \u064a\u064f\u0639\u0637\u0649 \u0628\u062c\u0631\u0639\u0629 20 mg\/kg\/day \u0641\u0645\u0648\u064a\u0651\u064e\u0627\u064b \u0648\u0644\u0645\u062f\u0651\u064e\u0629 4 \u0623\u064a\u0651\u064e\u0627\u0645\u064d\u060c \u0648\u0647\u0630\u0627 \u0645\u0627 \u0638\u0647\u0631 \u062c\u0644\u064a\u0651\u064e\u0627\u064b \u0645\u0650\u0646\u0652 \u062e\u0644\u0627\u0644 \u0638\u0647\u0648\u0631 \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0627\u062a \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0639\u064a\u0627\u0646\u064a\u0651\u064e\u0627\u064b \u0648\u0646\u0633\u064a\u062c\u064a\u0651\u064e\u0627\u064b\u060c \u0648\u0642\u062f \u0623\u0643\u0651\u064e\u062f\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0623\u0646\u0651\u064e \u0627\u0644\u0634\u0651\u0650\u062f\u0651\u064e\u0629 \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0651\u064e\u0629 \u0644\u0639\u0628\u062a \u062f\u0648\u0631\u0627\u064b \u0631\u0626\u064a\u0633\u064a\u0651\u064e\u0627\u064b \u0641\u064a \u062d\u062f\u0648\u062b \u0647\u0630\u0647 \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629.<\/p>\n<p>\u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0623\u0646\u0651\u064e \u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0627\u0644\u0645\u0639\u0637\u0649 \u0628\u062c\u0631\u0639\u0629 10 mg\/kg\/day \u0641\u0645\u0648\u064a\u0651\u064e\u0627\u064b \u0648\u0644\u0645\u062f\u0651\u064e\u0629\u0650 7 \u0623\u064a\u0651\u064e\u0627\u0645\u064d \u0648\u0642\u0628\u0644\u064e \u0633\u0627\u0639\u0629\u064d \u0645\u0650\u0646\u064e \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a \u0643\u0627\u0646 \u0642\u0627\u062f\u0631\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0650\u0646\u064e \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629\u0650 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0639\u064a\u0627\u0646\u064a\u0651\u064e\u0627\u064b \u0648\u0646\u0633\u064a\u062c\u064a\u0651\u064e\u0627\u064b\u060c \u0645\u0639 \u0639\u062f\u0645 \u0642\u062f\u0631\u062a\u0647 \u0639\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0634\u0651\u0650\u062f\u0651\u064e\u0629 \u0627\u0644\u062a\u0651\u064e\u0623\u0643\u0633\u062f\u064a\u0651\u064e\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0643\u0648\u0646 \u0648\u0627\u062d\u062f\u0629\u064b \u0645\u0650\u0646\u064e \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0651\u064e\u0629 \u0648\u0644\u0643\u0646 \u0642\u062f \u0644\u0627 \u062a\u0643\u0648\u0646 \u0627\u0644\u0623\u0647\u0645\u0651\u064e.<\/p>\n<p>\u0645\u0645\u0651\u064e\u0627 \u0633\u0628\u0642 \u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0633\u062a\u0646\u062a\u0627\u062c\u064f \u0623\u0646\u0651\u064e \u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u064a\u0645\u0643\u0646\u0647 \u062a\u062d\u0633\u064a\u0646\u064f \u0627\u0644\u0623\u0630\u064a\u0651\u064e\u0629\u0650 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0641\u064a \u0627\u0644\u0642\u0631\u062d\u0629 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 \u0627\u0644\u0645\u062d\u062f\u062b\u0629 \u0628\u0627\u0644\u0623\u0644\u064a\u0646\u062f\u0631\u0648\u0646\u0627\u062a.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a List of abbreviations<\/strong><\/p>\n<table style=\"width: 34.5076%; height: 1667px;\">\n<tbody>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\"><strong>\u0627\u0644\u0645<\/strong><strong>\u0642\u0627\u0628\u0644<\/strong><\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\"><strong>\u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Natural Control<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">NC<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Alendronate<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">ALD<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Atorvastatin<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">ATO<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Non-Steroidal Anti-inflammatory Drugs<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">NSAIDs<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Reactive Oxygen Species<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">ROS<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Reactive Oxygen Species<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">MDA<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">3-Hydroxy-3-methylglutaryl Coenzyme A<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">HMG-CoA<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Thiobarbeturic Acid<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">TBA<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Trichloroacetic Acid<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">TCA<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Low-density Lipoprotein Cholesterol<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">LDL-C<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Average number of ulcers per animal<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">UN<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Average of severity score<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">US<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Percentage of animals with ulcer<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">UP<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Micromole<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">\u03bcM<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Nitrogen-containing Bisphosphonates<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">N-BPs<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Myeloperoxidase<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">MPO<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Tumor Necrosis Factor Alpha<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">TNF-\u03b1<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Interleukin 1\u03b2<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">IL-1\u03b2<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Potential Difference<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">PD<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Nitric Oxide<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">NO<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Glutathione<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">GSH<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Prostaglandin E2<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">PGE2<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 68.4807%;\" width=\"207\">Inducible Nitric Oxide Synthase<\/td>\n<td style=\"text-align: center; width: 29.932%;\" width=\"104\">iNOS<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629<\/strong><strong> Ethics approval and consent to participate<\/strong><\/p>\n<p>\u062d\u0627\u0632 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0644\u062c\u0646\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0631\u0642\u0645 PH-180225-410.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d<\/strong><strong> Conflict of interests <\/strong><\/p>\n<p>\u064a\u0642\u0631\u0651 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644<\/strong><strong> Funding <\/strong><\/p>\n<p>\u0623\u064f\u062c\u0631\u064a \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u062f\u0648\u0646 \u062f\u0639\u0645 \u0645\u0627\u0644\u064a \u062e\u0627\u0631\u062c\u064a\u061b \u0648\u0642\u062f \u062a\u062d\u0645\u0644\u062a \u0627\u0644\u0628\u0627\u062d\u062b\u0629 \u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u0643\u0627\u0644\u064a\u0641.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646<\/strong><strong> Authors\u2019 contributions <\/strong><\/p>\n<p>\u062f\u064a\u0646\u0627 \u0645\u0627\u0647\u0631 \u0634\u0627\u0647\u064a\u0646: \u0642\u0627\u0645\u062a \u0628\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0648\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629\u060c \u0648\u062c\u0645\u0639 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0648\u062a\u062d\u0644\u064a\u0644\u0647\u0627 \u0648\u062a\u0641\u0633\u064a\u0631\u0647\u0627\u060c \u0648\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0645\u0633\u0648\u062f\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u0645\u0642\u0627\u0644.<\/p>\n<p>\u0634\u0627\u062f\u064a \u0645\u0635\u0637\u0641\u0649 \u062d\u0645\u0635\u064a: \u0642\u0627\u0645 \u0628\u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u062c\u0645\u064a\u0639 \u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0648\u0642\u062f\u0651\u0645 \u0627\u0644\u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0639\u0644\u0645\u064a \u0648\u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0627\u062a \u0627\u0644\u0646\u0642\u062f\u064a\u0629 \u062e\u0644\u0627\u0644 \u0625\u0639\u062f\u0627\u062f \u0627\u0644\u0628\u062d\u062b \u0648\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0645\u0642\u0627\u0644.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u064a\u0634\u0645\u0644 \u0645\u0631\u0636 \u0627\u0644\u0642\u0631\u062d\u0629 \u0627\u0644\u0647\u0636\u0645\u064a\u0651\u064e\u0629 \u0643\u064f\u0644\u0651\u064e\u0627\u064b \u0645\u0650\u0646\u064e \u0627\u0644\u0642\u0631\u062d\u0629\u0650 \u0627\u0644\u0645\u064e\u0639\u0650\u062f\u064a\u0651\u064e\u0629 Gastric Ulcer\u060c \u0648\u0642\u0631\u062d\u0629\u0650 \u0627\u0644\u0627\u062b\u0646\u064a \u0639\u0634\u0631 Duodenal Ulcer\u060c \u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0629\u064c \u0639\u0646 \u0623\u0630\u064a\u0651\u064e\u0629\u064d \u062a\u062e\u062a\u0631\u0642&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=1974\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":1990,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-1974","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-155","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/1974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1974"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/1974\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/1990"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}