{"id":2006,"date":"2025-04-26T13:50:39","date_gmt":"2025-04-26T13:50:39","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2006"},"modified":"2025-04-26T13:50:39","modified_gmt":"2025-04-26T13:50:39","slug":"%d8%aa%d9%88%d8%a7%d8%aa%d8%b1-%d8%a7%d9%84%d8%aa%d8%b9%d8%af%d9%91%d8%af-%d8%a7%d9%84%d8%b4%d9%83%d9%84%d9%8a%d9%91-bsmi-%d9%81%d9%8a-%d8%ac%d9%8a%d9%86-vdr-%d9%84%d8%af%d9%89-%d8%ac%d9%85%d9%87","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2006","title":{"rendered":"\u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 BsmI \u0641\u064a \u062c\u064a\u0646 VDR \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0633\u0648\u0631\u064a\u0627\u062a \u0623\u0635\u062d\u0627\u0621 \u0648\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a"},"content":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 <\/strong>Introduction<\/strong><\/p>\n

\u062a\u0639\u062f\u0651 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0627\u0644\u0625\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u063a\u062f\u064a\u0651 \u0627\u0644\u0635\u0645\u0627\u0648\u064a\u0651 Endocrine Disorder \u0627\u0644\u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u0627\u064b \u0639\u0646\u062f \u0627\u0644\u0646\u0633\u0627\u0621 \u0641\u064a \u0633\u0646 \u0627\u0644\u0625\u0646\u062c\u0627\u0628\u060c \u064a\u0635\u064a\u0628 \u0627\u0644\u0646\u0633\u0627\u0621 \u0645\u0646 \u0639\u0645\u0631 18 \u062d\u062a\u0649 44 \u0639\u0627\u0645\u0627\u064b\u060c \u0648\u0628\u0645\u0639\u062f\u0651\u0644 \u0627\u0646\u062a\u0634\u0627\u0631 \u064a\u0635\u0644 \u0625\u0644\u0649 10-15% \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u062a\u0651\u0628\u0639\u0629 \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0651\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u064a \u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u062c\u063a\u0631\u0627\u0641\u064a\u0651\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629(1,2)<\/sup>\u060c \u0648\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0623\u062c\u0631\u064a\u062a \u0645\u0624\u062e\u0631\u0627\u064b \u0641\u064a \u0633\u0648\u0631\u064a\u0627 \u062a\u0628\u064a\u0651\u064e\u0646 \u0623\u0646 \u0645\u0639\u062f\u0644 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u064a\u0628\u0644\u063a 27.4%(3)<\/sup>.<\/p>\n

\u062a\u062a\u0635\u0641 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u0623\u0646\u0647\u0627 \u0645\u0631\u0636 \u0645\u0639\u0642\u0651\u062f Complex \u0648\u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0639\u0648\u0627\u0645\u0644 Multifactorial\u060c \u062a\u062a\u062f\u0627\u062e\u0644 \u0641\u064a\u0647\u0627 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0628\u0651\u0628\u0629 \u0627\u0644\u0635\u0645\u0627\u0648\u064a\u0651\u0629 \u0648\u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0628\u064a\u0626\u064a\u0651\u0629(4,5)<\/sup>\u060c \u0648\u0625\u0646 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u0634\u0643\u0644 \u0648\u0627\u0636\u062d \u0644\u062f\u0649 \u0627\u0644\u0623\u0642\u0627\u0631\u0628 \u0645\u0646 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0628\u0646\u0633\u0628\u0629 \u062a\u064f\u0642\u0627\u0631\u0650\u0628 55-60% \u0641\u064a \u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u064a\u062f\u0639\u0645 \u0641\u0631\u0636\u064a\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u062c\u0633\u062f\u064a\u0651\u0629 \u0627\u0644\u0633\u0627\u0626\u062f\u0629 \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 Autosomal Dominant Inheritance(5)<\/sup>.<\/p>\n

\u064a\u062a\u0645 \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0631\u0648\u062a\u0631\u062f\u0627\u0645 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0628\u0648\u062c\u0648\u062f \u0645\u0639\u0644\u064e\u0645\u064a\u0646 \u0645\u0646 \u0623\u0635\u0644 \u062b\u0644\u0627\u062b\u0629: \u0642\u0644\u0651\u0629 \u0623\u0648 \u0627\u0646\u0639\u062f\u0627\u0645 \u0627\u0644\u0625\u0628\u0627\u0636\u0629 Oligo-anovulation\u060c \u0641\u0631\u0637 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 Hyperandrogenism\u060c \u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a Polycystic Ovaries (\u0648\u062c\u0648\u062f 20 \u062c\u0631\u064a\u0628 \u0623\u0648 \u0623\u0643\u062b\u0631 \u0628\u0642\u0637\u0631 2-9 \u0645\u0644\u0645 \u0623\u0648 \u0623\u0643\u062b\u0631 \u0641\u064a \u0643\u0644 \u0645\u0628\u064a\u0636 \u0648\/\u0623\u0648 \u0648\u062c\u0648\u062f \u0645\u0628\u064a\u0636 \u0628\u062d\u062c\u0645 \u064a\u062a\u062c\u0627\u0648\u0632 10 \u0645\u0644)(6)<\/sup>.<\/p>\n

\u062a\u0648\u0633\u0651\u0639\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u0644\u0651\u0642\u0629 \u0628\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0628\u0651\u0628\u0629 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0644\u062a\u0634\u0645\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0642\u062f \u0644\u0648\u062d\u0638 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u064a\u0646 \u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0648\u062f\u0627\u062e\u0644\u0647\u0627 \u0644\u0643\u0646\u0651\u0647 \u064a\u0631\u062a\u0628\u0637 \u0628\u0645\u0633\u0627\u0631\u064d \u0645\u0634\u062a\u0631\u0643\u064d\u060c \u0648\u0645\u0646\u0647\u0627: \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0635\u0637\u0646\u0627\u0639 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u0648\u0627\u0644\u0643\u0638\u0631 (CYP11a\u060c CYP21\u060c CYP17) \u0648\u062c\u064a\u0646 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 Androgen Receptor (AR) \u0648\u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0639\u0645\u0644 \u0648\u062a\u0646\u0638\u064a\u0645 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u062a\u0646\u0627\u0633\u0644\u064a\u0629 (LH\u060c FSHR) \u0648\u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0625\u0646\u062a\u0627\u062c \u0648\u0639\u0645\u0644 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u062c\u064a\u0646 \u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D(<\/sup>5,7,8<\/sup>)<\/sup>.<\/p>\n

\u064a\u062a\u0645 \u062a\u0646\u0638\u064a\u0645 \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 3% \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0628\u0634\u0643\u0644 \u0645\u0628\u0627\u0634\u0631 \u0623\u0648 \u063a\u064a\u0631 \u0645\u0628\u0627\u0634\u0631 \u0628\u0648\u0627\u0633\u0637\u0629 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0648\u0645\u0633\u062a\u0642\u0628\u0644\u0647\u060c \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0644\u0623\u062f\u0648\u0627\u0631 \u0627\u0644\u0647\u0627\u0645\u0629 \u0648\u0627\u0644\u0648\u0627\u0633\u0639\u0629 \u0644\u0647\u0645\u0627 \u0641\u064a \u0627\u0644\u0635\u062d\u0651\u0629 \u0648\u0627\u0644\u0645\u0631\u0636(9)<\/sup>\u060c \u0648\u0642\u062f \u0639\u064f\u062b\u0631 \u0639\u0644\u0649 \u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0641\u064a \u0643\u0644 \u0645\u0646 \u0627\u0644\u0645\u0628\u064a\u0636 \u0648\u0627\u0644\u0631\u062d\u0645 \u0648\u0642\u0646\u0627\u0629 \u0641\u0627\u0644\u0648\u0628 \u0648\u0627\u0644\u0645\u0647\u0628\u0644 \u0648\u0627\u0644\u0645\u0634\u064a\u0645\u0629 \u0644\u062f\u0649 \u0627\u0644\u0628\u0634\u0631 \u0648\u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a\u060c \u0647\u0630\u0627 \u0645\u0627 \u064a\u0624\u0643\u0651\u062f \u0639\u0644\u0649 \u0627\u0644\u062f\u0648\u0631 \u0627\u0644\u0645\u0628\u0627\u0634\u0631 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u062d\u064a\u062b \u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0623\u0646 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u064a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0647\u0627\u0645\u0627\u064b \u0641\u064a \u062a\u0646\u0638\u064a\u0645 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0651\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u062f\u0651\u062f \u062e\u0635\u0648\u0628\u0629 \u0627\u0644\u0623\u0646\u062b\u0649\u060c \u0643\u0645\u0627 \u064a\u0645\u0644\u0643 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u062a\u0623\u062b\u064a\u0631\u0627 \u062a\u062d\u0641\u064a\u0632\u064a\u0627\u064b \u0639\u0644\u0649 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0625\u0633\u062a\u0631\u0627\u062f\u064a\u0648\u0644 \u0648\u0627\u0644\u0625\u0633\u062a\u0631\u0648\u0646 \u0648\u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632 CYP19A1 \u0627\u0644\u0630\u064a \u064a\u062d\u0648\u0651\u0644 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 \u0625\u0644\u0649 \u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u060c \u0648\u062a\u0632\u0627\u064a\u062f\u062a \u0645\u0624\u062e\u0651\u0631\u0627\u064b \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u0649 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0645\u0639 \u0646\u0642\u0635 \u0627\u0644\u062e\u0635\u0648\u0628\u0629 \u0648\u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628\u064a\u0651\u0629 \u0648\u0627\u0644\u0635\u0645\u0627\u0648\u064a\u0651\u0629 \u0648\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u0633\u064a\u0627\u062a(10,11,12)<\/sup>.<\/p>\n

\u064a\u0645\u0627\u0631\u0633 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0648\u0638\u0627\u0626\u0641\u0647 \u0627\u0644\u062d\u064a\u0648\u064a\u0651\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0631\u062a\u0628\u0627\u0637\u0647 \u0628\u0623\u0644\u0641\u0629 \u0639\u0627\u0644\u064a\u0629 \u0645\u0639 \u0645\u0633\u062a\u0642\u0628\u0644\u0647 \u0627\u0644\u0646\u0648\u0648\u064a VDR<\/em>. \u062a\u0624\u062b\u0631 \u0627\u0644\u062a\u0639\u062f\u0651\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0651\u0629 \u0641\u064a \u062c\u064a\u0646 VDR<\/em> \u0628\u0648\u0638\u064a\u0641\u062a\u0647 \u0648\u062a\u0631\u062a\u0628\u0637 \u0645\u0639 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0644\u0627\u0633\u064a\u0645\u0627 \u0627\u0644\u0645\u062a\u0639\u0644\u0651\u0642\u0629 \u0628\u0646\u0642\u0635 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D. \u064a\u062a\u0648\u0636\u0639 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 BsmI<\/em> (rs1544410) G>A \u0641\u064a \u0627\u0644\u0625\u0646\u062a\u0631\u0648\u0646 \u0627\u0644\u062b\u0627\u0645\u0646 \u0642\u0631\u0628 \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u20323 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u0631\u062c\u0645\u0629 untranslated region \u00a0(3\u2032UTR) \u0648\u064a\u0624\u062b\u0631 \u0647\u0630\u0627 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0641\u064a \u062b\u0628\u0627\u062a\u064a\u0629 \u0648\u0627\u0633\u062a\u0642\u0631\u0627\u0631 mRNA \u0627\u0644\u0645\u064f\u0646\u062a\u0633\u062e (13)<\/sup>\u060c \u0643\u0645\u0627 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062b\u0631 \u0647\u0630\u0627 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 \u0641\u064a \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0639\u0646 VDR<\/em> \u0645\u0645\u0651\u0627 \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0627\u0644\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u062d\u064a\u0648\u064a\u0651\u0629 \u0627\u0644\u0647\u0627\u0645\u0651\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0633\u062a\u0642\u0628\u0644\u0647(14,15)<\/sup>.<\/p>\n

\u00a0<\/strong><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong>Materials and Methods<\/strong><\/p>\n

\u062a\u0645 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0646\u0645\u0637 \u062d\u0627\u0644\u0629 \u0634\u0627\u0647\u062f Case-Control \u0634\u0645\u0644\u062a 50 \u0645\u0631\u064a\u0636\u0629 \u0645\u0634\u062e\u0635\u0629 \u0628\u0640 PCOS \u064853 \u0633\u064a\u062f\u0629 \u0633\u0644\u064a\u0645\u0629 \u0643\u0634\u0627\u0647\u062f\u060c \u0648\u0643\u0627\u0646\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 Inclusion Criteria \u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0651\u0629: \u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0634\u062e\u0651\u0635\u0627\u062a \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a\u060c \u0623\u0645\u0627 \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f Exclusion Criteria: \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0644\u0648\u0627\u062a\u064a \u0644\u062f\u064a\u0647\u0646 \u0623\u0633\u0628\u0627\u0628 \u0623\u062e\u0631\u0649 \u0644\u0641\u0631\u0637 \u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 \u0627\u0644\u062f\u0651\u0645 \u0645\u062b\u0644 \u0641\u0631\u0637 \u0628\u0631\u0648\u0644\u0627\u0643\u062a\u064a\u0646 \u0627\u0644\u062f\u0651\u0645 \u0648\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u0641\u0631\u0632\u0629 \u0644\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 \u0648\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0643\u0648\u0634\u064a\u0646\u063a\u060c \u0623\u0648 \u0627\u0644\u0644\u0648\u0627\u062a\u064a \u0644\u062f\u064a\u0647\u0646 \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649 \u0643\u0627\u0644\u0633\u0643\u0631\u064a\u0651 \u0623\u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636 \u0623\u0648 \u0627\u0644\u0643\u0638\u0631 \u0623\u0648 \u0641\u0631\u0637 \u062a\u0646\u0633\u062c \u0643\u0638\u0631\u064a \u062e\u0644\u0642\u064a\u060c \u0648\u0627\u0644\u062d\u0648\u0627\u0645\u0644\u060c \u0648\u0627\u0644\u0644\u0648\u0627\u062a\u064a \u064a\u062a\u0646\u0627\u0648\u0644\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0624\u062b\u0651\u0631\u0629 \u0639\u0644\u0649 \u062a\u0648\u0627\u0632\u0646 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0645\u062b\u0644 \u0627\u0644\u0643\u0648\u0631\u062a\u064a\u0643\u0648\u0633\u062a\u064a\u0631\u0648\u0626\u064a\u062f\u0627\u062a\u060c \u0648\u0643\u0630\u0644\u0643 \u0645\u062a\u0645\u0651\u0645\u0627\u062a \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0645\u062b\u0644 \u0645\u0627\u0646\u0639\u0627\u062a \u0627\u0644\u062d\u0645\u0644 \u0627\u0644\u0641\u0645\u0648\u064a\u0651\u0629 \u0623\u0648 \u0645\u0636\u0627\u062f\u0651\u0627\u062a \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646.<\/p>\n

\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629: \u0633\u064a\u062f\u0627\u062a \u0630\u0648\u0627\u062a \u062f\u0648\u0631\u0627\u062a \u0634\u0647\u0631\u064a\u0651\u0629 \u0645\u0646\u062a\u0638\u0645\u0629\u060c \u0645\u0634\u0639\u0631 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 \u0636\u0645\u0646 \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u060c \u0645\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0637\u0628\u064a\u0639\u064a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 \u0648\u0644\u064a\u0633 \u0644\u062f\u064a\u0647\u0645 \u0623\u064a \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a\u0651 \u0644\u0644\u0634\u0639\u0631\u0627\u0646\u064a\u0651\u0629\u060c \u0648\u0645\u062a\u0637\u0627\u0628\u0642\u0629 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0651\u0629 \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u0641\u0626\u0629 \u0627\u0644\u0639\u0645\u0631\u064a\u0629 (18-44 \u0633\u0646\u0629).<\/p>\n

\u062d\u0635\u0644\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a\u0651 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 24\/10\/2023\u060c \u0648\u0628\u0631\u0642\u0645 5675.<\/p>\n

\u062a\u0645 \u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0644\u0644\u0623\u0635\u062d\u0651\u0627\u0621 \u0648\u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0648\u0627\u0642\u0639\u0629 \u0628\u064a\u0646 \u0634\u0647\u0631 \u0623\u064a\u0644\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2023 \u062d\u062a\u0649 \u0634\u0647\u0631 \u0623\u064a\u0627\u0631 \u0645\u0646 \u0639\u0627\u0645 2024 \u0625\u0630 \u0628\u064f\u0632\u0644 3 \u0645\u0644 \u062f\u0645 \u0645\u0646 \u0643\u0644 \u0645\u0634\u0627\u0631\u0643 \u0639\u0644\u0649 \u0623\u0646\u0628\u0648\u0628 \u064a\u062d\u0648\u064a \u0645\u0627\u0646\u0639 \u062a\u062e\u062b\u0651\u0631 EDTA\u060c \u0648\u0645\u0646 \u062b\u0645 \u0627\u0633\u062a\u064f\u062e\u0644\u0635 DNA \u0628\u0637\u0631\u064a\u0642\u0629 \u064a\u062f\u0648\u064a\u0651\u0629 \u0646\u0627\u062c\u062d\u0629 \u0645\u0639\u062a\u0645\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u064a\u0648\u0631\u064a\u0627 \u0646\u0638\u0631\u0627\u064b \u0644\u062e\u0648\u0627\u0635\u0647\u0627 \u0627\u0644\u0645\u0645\u0633\u062e\u0629 \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0648\u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 DNase\u060c \u0648\u0643\u0627\u0646\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0630\u0627\u062a \u062a\u0631\u0643\u064a\u0632 \u0648\u0646\u0642\u0627\u0648\u0629 \u062c\u064a\u062f\u064a\u0646.<\/p>\n

\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u062a\u0641\u0627\u0639\u0644 Polymerase Chain Reaction (PCR) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0634\u0627\u0631\u0639 \u0630\u0627\u062a \u0627\u0644\u062a\u0633\u0644\u0633\u0644(16,17)<\/sup>:<\/p>\n

For 5\u2019-CAACCAAGACTACAAGTACCGCGTCAGTGA-3\u2019<\/p>\n

Rev 5\u2019-CACTTCGAGCACAAGGGGCGTTAGC-3\u2019<\/p>\n

\u0648\u0627\u0644\u062a\u064a \u062a\u0639\u0637\u064a \u0634\u062f\u0641\u0629 \u0628\u0637\u0648\u0644 2000bp \u062a\u062d\u0648\u064a \u0645\u0648\u0642\u0639 \u0627\u0644\u0642\u0637\u0639 \u0644\u0625\u0646\u0632\u064a\u0645 BsmI<\/em> \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0651 \u0627\u0644\u062a\u0627\u0644\u064a:<\/p>\n

\"\"<\/p>\n

\u0623\u064f\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u0648\u0627\u062a\u062c \u0628\u0627\u0644\u062a\u0631\u062d\u064a\u0644 \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0622\u063a\u0627\u0631\u0648\u0632 1.5%.<\/p>\n

\u0627\u0644\u0647\u0636\u0645 \u0628\u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0642\u0637\u0639: \u0627\u0633\u062a\u064f\u062e\u062f\u0645 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0645\u0646 \u0634\u0631\u0643\u0629 NewEngland Biolabs \u0648\u064a\u0639\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 65\u00ba \u0648\u064a\u0641\u0642\u062f \u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0628\u0627\u0644\u062d\u0636\u0646 \u0641\u064a 80\u00ba \u0644\u0645\u062f\u0629 20 \u062f\u0642\u064a\u0642\u0629\u060c \u0648\u0623\u064f\u0638\u0647\u0631\u062a \u0646\u0648\u0627\u062a\u062c \u0627\u0644\u0642\u0637\u0639 \u0628\u0627\u0644\u062a\u0631\u062d\u064a\u0644 \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0622\u063a\u0627\u0631\u0648\u0632 1%.<\/p>\n

\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651 \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c GraphPad Prism (version 8.0.1).<\/p>\n

\u062a\u0645 \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0651 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 Chi-square \u0644\u0645\u0639\u0631\u0641\u0629 \u0641\u064a\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u064a\u064f\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P-value< 0.05)\u060c \u0623\u0648 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0627\u0644\u0645\u0635\u0627\u062f\u0641\u0629 (P-value> 0.05).<\/p>\n

\u00a0<\/strong><\/p>\n

\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong>Results<\/strong><\/p>\n

\u064a\u0646\u062a\u062c \u0639\u0646 \u062a\u0641\u0627\u0639\u0644 PCR \u0634\u062f\u0641\u0629 \u0645\u0646 DNA \u0628\u0637\u0648\u0644 2000bp (\u0627\u0644\u0634\u0643\u0644 1).<\/p>\n

\"\"<\/p>\n

\u0639\u0646\u062f \u0627\u0644\u0647\u0636\u0645 \u0628\u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0642\u0637\u0639 \u062a\u0638\u0647\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0628\u0639\u062f \u0627\u0644\u0631\u062d\u0644\u0627\u0646 \u0628\u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062a\u0627\u0644\u064a: \u062d\u0627\u0644\u0629 \u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a Homozygotic \u0628\u063a\u064a\u0627\u0628 \u0645\u0648\u0642\u0639 \u0627\u0644\u0642\u0637\u0639 \u062a\u0638\u0647\u0631 \u0639\u0635\u0627\u0628\u0629 \u0648\u0627\u062d\u062f\u0629 \u0628\u0637\u0648\u0644 2000bp (\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a BB)\u060c \u062d\u0627\u0644\u0629 \u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a Homozygotic \u0628\u0648\u062c\u0648\u062f \u0645\u0648\u0642\u0639 \u0627\u0644\u0642\u0637\u0639 \u062a\u0638\u0647\u0631 \u0639\u0635\u0627\u0628\u062a\u064a\u0646 \u0628\u0637\u0648\u0644 650bp \u06481350bp (\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a bb)\u060c \u062d\u0627\u0644\u0629 \u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u0632\u064a\u062c\u0648\u062a Heterozygotic \u062a\u0638\u0647\u0631 \u062b\u0644\u0627\u062b \u0639\u0635\u0627\u0628\u0627\u062a (2000, 1350, 650) (\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a Bb) (\u0627\u0644\u0634\u0643\u0644 2).<\/p>\n

\"\"<\/p>\n

 <\/p>\n

\u062d\u064a\u062b \u062a\u0648\u0632\u0651\u0639\u062a \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0643\u0627\u0644\u062a\u0651\u0627\u0644\u064a: 35 \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a (70%) \u0645\u062a\u063a\u0627\u064a\u0631\u064a \u0627\u0644\u0632\u064a\u062c\u0648\u062a\u060c 10 \u0645\u0631\u064a\u0636\u0627\u062a (20%) \u0645\u062a\u0645\u0627\u062b\u0644\u064a \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0623\u0644\u064a\u0644 B \u06485 \u0645\u0631\u064a\u0636\u0627\u062a (10%) \u0645\u062a\u0645\u0627\u062b\u0644\u064a \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0623\u0644\u064a\u0644 b.<\/p>\n

\u0641\u064a \u062d\u064a\u0646 \u0643\u0627\u0646\u062a 26 \u0623\u0646\u062b\u0649 \u0633\u0644\u064a\u0645\u0629 (49%) \u0645\u062a\u063a\u0627\u064a\u0631\u064a \u0627\u0644\u0632\u064a\u062c\u0648\u062a\u060c 18 \u0623\u0646\u062b\u0649 \u0633\u0644\u064a\u0645\u0629 (34%) \u0645\u062a\u0645\u0627\u062b\u0644\u064a \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0623\u0644\u064a\u0644 B\u060c 10 \u0623\u0646\u062b\u0649 \u0633\u0644\u064a\u0645\u0629 (17%) \u0645\u062a\u0645\u0627\u062b\u0644\u064a \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0623\u0644\u064a\u0644 b\u060c \u0648 \u0639\u0646\u062f \u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0645\u0631\u0628\u0639 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u062a\u064a\u0646 \u0644\u0645 \u064a\u0643\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0645\u064f\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0651\u0629 \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 P value \u062a\u0633\u0627\u0648\u064a 0.0967.<\/p>\n

\"\"<\/p>\n

\u062a\u0648\u0632\u0639\u062a \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0643\u0627\u0644\u062a\u0627\u0644\u064a: 55 (55%) \u0623\u0644\u064a\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 B \u064862 (45%) \u0623\u0644\u064a\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 b \u0639\u0646\u062f \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0642\u0627\u0628\u0644 62 (58%) \u0623\u0644\u064a\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 B \u064844 (42%) \u0623\u0644\u064a\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 b \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629.<\/p>\n

\u0639\u0646\u062f \u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0645\u0631\u0628\u0639 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u062a\u064a\u0646 \u0644\u0645 \u064a\u0643\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u00a0\u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u062d\u064a\u062b \u0643\u0627\u0646\u062a P value \u062a\u0633\u0627\u0648\u064a 0.6735.<\/p>\n

\"\"<\/p>\n

\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong>Discussion<\/strong><\/p>\n

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u0639\u0642\u0651\u062f\u0629 \u0645\u062a\u0639\u062f\u0651\u062f\u0629 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0628\u0651\u0628\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0624\u062b\u0651\u0631 \u0639\u0644\u0649 \u0646\u0648\u0639\u064a\u0651\u0629 \u062d\u064a\u0627\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0629\u060c \u0648\u0644\u0647\u0627 \u0639\u062f\u062f \u0645\u0646 \u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u0646\u0641\u0633\u064a\u0651\u0629 \u0648\u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629\u060c \u0648\u0644\u0645 \u062a\u062d\u062f\u0651\u062f \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0628\u0651\u0628\u0629 \u0628\u062f\u0642\u0651\u0629 \u0628\u0644 \u062a\u0646\u0648\u0639\u062a \u0628\u064a\u0646 \u0639\u0648\u0627\u0645\u0644 \u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629 \u0648\u0628\u064a\u0626\u064a\u0651\u0629 \u0648\u062c\u064a\u0646\u064a\u0651\u0629\u060c \u0648\u0645\u0646 \u062c\u0647\u0629 \u0623\u062e\u0631\u0649 \u062a\u0646\u0627\u0648\u0644\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0627\u062a \u0641\u064a \u0633\u0648\u0631\u064a\u0651\u0629 \u0627\u0644\u062a\u0639\u062f\u0651\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0651\u0629 \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0648\u0639\u0644\u0627\u0642\u062a\u0647\u0627 \u0645\u0639 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0645\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0644\u062f\u0649 \u0627\u0644\u0623\u0635\u062d\u0627\u0621.<\/p>\n

\u0644\u0648\u062d\u0638 \u0648\u062c\u0648\u062f \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u0644\u0627\u0633\u064a\u0645\u0627 Bb \u062d\u064a\u062b \u0643\u0627\u0646 \u0623\u0639\u0644\u0649 \u0639\u0646\u062f \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0648\u0644\u0643\u0646 \u0644\u0645 \u064a\u0643\u0646 \u0647\u0630\u0627 \u0627\u0644\u0641\u0627\u0631\u0642 \u0645\u064f\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 p>0.05. \u0648\u0642\u062f \u062a\u0648\u0627\u0641\u0642\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0643\u0644 \u0645\u0646 Bagheri \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0641\u064a \u062a\u0631\u0643\u064a\u0627 \u0648 Song \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0641\u064a \u0643\u0648\u0631\u064a\u0627 \u0648 Ramezani\u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0648 Mahmoudi\u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0641\u064a \u0625\u064a\u0631\u0627\u0646(18,19,20,21)<\/sup>\u060c \u0648\u0627\u062e\u062a\u0644\u0641\u0646\u0627 \u0645\u0639 Shi \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0641\u064a \u0627\u0644\u0635\u064a\u0646(22)<\/sup> \u0627\u0644\u0630\u064a\u0646 \u0648\u062c\u062f\u0648\u0627 \u0627\u0631\u062a\u0628\u0627\u0637\u0627\u064b \u0628\u064a\u0646 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a BsmI<\/em> \u0648\u0627\u0644\u0623\u0647\u0628\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a\u060c \u0648\u0643\u0630\u0644\u0643 Xavier \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0641\u064a \u0627\u0644\u0628\u0631\u0627\u0632\u064a\u0644 \u0627\u0644\u0630\u064a\u0646 \u0648\u062c\u062f\u0648 \u0623\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a Bb \u0645\u0631\u062a\u0628\u0637 \u0645\u0639 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a(23)<\/sup>.<\/p>\n

\u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0639\u0632\u0649 \u062a\u0644\u0643 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0625\u0644\u0649 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0627\u0644\u0628\u064a\u0626\u064a\u0651\u0629 \u0648\u0627\u0644\u0639\u0631\u0642\u064a\u0651\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u062a\u0645\u0639\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u062d\u064a\u062b \u0623\u0646\u0647 \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u062a\u0639\u062f\u0651\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0629 \u0645\u0639 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0628\u064a\u0626\u064a\u0651\u0629 \u0648\u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0642\u0627\u0628\u0644\u064a\u0651\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0648\u0644\u0627\u0633\u064a\u0645\u0627 \u0623\u0646 PCOS \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u062a\u0639\u062f\u0651\u062f\u0629 \u0627\u0644\u0639\u0648\u0627\u0645\u0644\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0644\u0639\u062f\u0629 \u062c\u064a\u0646\u0627\u062a \u062a\u0623\u062b\u064a\u0631\u064c \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u062d\u064a\u062b \u064a\u0643\u0648\u0646 \u0644\u0643\u0644 \u062c\u064a\u0646 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0623\u0635\u063a\u0631\u064a\u0651\u0629\u060c \u0643\u0645\u0627 \u0623\u0646 \u0639\u062f\u062f \u0648\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0642\u062f \u064a\u062e\u062a\u0644\u0641 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0639\u0631\u0642\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629\u060c \u0625\u0636\u0627\u0641\u0629\u064b \u0625\u0644\u0649 \u0627\u062e\u062a\u0644\u0627\u0641 \u062d\u062c\u0645 \u0627\u0644\u0639\u064a\u0646\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u062d\u064a\u062b \u0623\u0646\u0651 \u0639\u062f\u062f \u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0639\u064a\u0651\u0646\u0629 \u0644\u0647 \u062f\u0648\u0631 \u0645\u0647\u0645\u0651 \u0641\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0628\u062d\u062b \u0641\u064a \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0644\u062a\u0639\u062f\u0651\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0651\u0629 \u0648\u0623\u0645\u0631\u0627\u0636 \u0645\u0639\u064a\u0651\u0646\u0629\u060c \u0648\u062a\u0643\u0648\u0646 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0643\u062b\u0631 \u0645\u0648\u062b\u0648\u0642\u064a\u0651\u0629\u064b \u0645\u0639 \u0627\u0644\u062d\u062c\u0645 \u0627\u0644\u0643\u0628\u064a\u0631 \u0644\u0644\u0639\u064a\u0651\u0646\u0629\u060c \u0648\u0647\u0630\u0627 \u064a\u0639\u062f\u0651 \u0623\u062d\u062f \u0645\u062d\u062f\u0648\u062f\u064a\u0627\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n

 <\/p>\n

\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong><\/p>\n

\u062a\u0639\u062f \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u0623\u0648\u0644\u0649 \u0641\u064a \u0633\u0648\u0631\u064a\u0629 \u0641\u064a \u062a\u062d\u0631\u0651\u064a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 BsmI<\/em> \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a PCOS \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0641\u0631\u0648\u0642\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0641\u064a \u0646\u0633\u0628 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0644\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 BsmI<\/em> \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0648\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651BsmI<\/em> \u00a0\u0641\u064a \u062c\u064a\u0646VDR<\/em> \u00a0\u0648\u0627\u0644\u0623\u0647\u0628\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0644\u062f\u0649 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0633\u0648\u0631\u064a\u0627\u062a \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0633\u0644\u064a\u0645\u0629 \u0634\u0627\u0647\u062f\u0629.<\/p>\n

 <\/p>\n

\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a<\/strong> List of abbreviations <\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\u0627\u0644\u0645\u0642\u0627\u0628\u0644<\/strong><\/td>\n\u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631<\/strong><\/td>\n<\/tr>\n
3\u2032 untranslated region<\/td>\n3\u2032UTR<\/td>\n<\/tr>\n
Androgen Receptor<\/td>\nAR<\/td>\n<\/tr>\n
Follicle-stimulating hormone receptor<\/td>\nFSHR<\/td>\n<\/tr>\n
Luteinizing hormone<\/td>\nLH<\/td>\n<\/tr>\n
messenger ribonucleic acid<\/td>\nmRNA<\/td>\n<\/tr>\n
Polycystic ovary syndrome<\/td>\nPCOS<\/td>\n<\/tr>\n
Polymerase chain reaction<\/td>\nPCR<\/td>\n<\/tr>\n
Restriction fragment length polymorphism<\/td>\nRFLP<\/td>\n<\/tr>\n
Vitamin D receptor<\/td>\nVDR<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629<\/strong> Ethics approval and consent to participate<\/strong><\/p>\n

\u062d\u0635\u0644\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a\u0651 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 24\/10\/2023\u060c \u0648\u0628\u0631\u0642\u0645 5675.<\/p>\n

 <\/p>\n

\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d<\/strong> Conflict of interests <\/strong><\/p>\n

\u064a\u0642\u0631 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n

 <\/p>\n

\u0627\u0644\u062a\u0645\u0648\u064a<\/strong>\u0644 <\/strong>\u00a0<\/strong>\u00a0Funding<\/strong><\/p>\n

\u062a\u0645 \u062a\u0645\u0648\u064a\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u0642\u0650\u0628\u064e\u0644 \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/p>\n

 <\/p>\n

\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646<\/strong> Authors\u2019 contributions <\/strong><\/p>\n

\u0622\u064a\u0647 \u0627\u0633\u0645\u0627\u0639\u064a\u0644: \u0627\u0644\u0628\u0627\u062d\u062b \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u060c \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0639\u0645\u0644\u064a \u0645\u0646 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0646\u0638\u0631\u064a\u0629 \u0644\u0644\u0623\u0637\u0631\u0648\u062d\u0629 \u0648\u0627\u0644\u0645\u0642\u0627\u0644\u0629.<\/p>\n

\u0645\u0631\u0648\u0627\u0646 \u0627\u0644\u062d\u0644\u0628\u064a: \u0627\u0644\u0645\u0634\u0631\u0641 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u060c \u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0639\u0644\u0649 \u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0628 \u0627\u0644\u0645\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a.<\/p>\n

\u0634\u0627\u062f\u0646 \u062d\u062f\u0627\u062f: \u0627\u0644\u0645\u0634\u0631\u0641 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0641\u064a \u0627\u0644\u0628\u062d\u062b\u060c \u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u062c\u0645\u064a\u0639 \u062a\u0641\u0627\u0635\u064a\u0644 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u062a\u0635\u0645\u064a\u0645 \u062e\u0637\u0629 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u062a\u0648\u062c\u064a\u0647\u0627\u062a \u0641\u064a \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0639\u0645\u0644\u064a \u0648\u062a\u062f\u0642\u064a\u0642 \u0627\u0644\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0646\u0638\u0631\u064a\u0629.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u062a\u0639\u062f\u0651 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0627\u0644\u0625\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u063a\u062f\u064a\u0651 \u0627\u0644\u0635\u0645\u0627\u0648\u064a\u0651 Endocrine Disorder \u0627\u0644\u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u0627\u064b \u0639\u0646\u062f \u0627\u0644\u0646\u0633\u0627\u0621 \u0641\u064a \u0633\u0646 \u0627\u0644\u0625\u0646\u062c\u0627\u0628\u060c \u064a\u0635\u064a\u0628 \u0627\u0644\u0646\u0633\u0627\u0621 \u0645\u0646…
\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2012,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2006","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-155","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2006"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2006\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2012"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}