{"id":2029,"date":"2025-08-23T08:13:03","date_gmt":"2025-08-23T08:13:03","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2029"},"modified":"2025-08-23T08:13:03","modified_gmt":"2025-08-23T08:13:03","slug":"%d8%a7%d8%ae%d8%aa%d9%84%d8%a7%d9%81-%d8%a7%d9%84%d9%85%d8%b3%d8%aa%d9%88%d9%8a%d8%a7%d8%aa-%d8%a7%d9%84%d9%85%d8%b5%d9%84%d9%8a%d9%91%d8%a9-%d9%84%d9%84%d8%ad%d8%af%d9%8a%d8%af-%d8%aa%d8%a8%d8%b9","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2029","title":{"rendered":"\u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0644\u0644\u062d\u062f\u064a\u062f \u062a\u0628\u0639\u0627\u064b \u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0633\u0648\u0631\u064a\u0651\u0627\u062a \u0645\u064f\u0634\u062e\u0651\u064e\u0635\u0627\u062a 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\u0628\u0623\u0647\u062f\u0627\u0641 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0648\u0642\u064f\u0645\u0646\u064e \u0628\u062a\u0648\u0642\u064a\u0639 \u0646\u0645\u0648\u0630\u062c \u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u062e\u0637\u064a\u0651\u0629 \u0645\u0633\u062a\u0646\u064a\u0631\u0629. \u062d\u0635\u0644\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0645\u062c\u0644\u0633 \u0623\u062e\u0644\u0627\u0642\u064a\u0651\u0627\u062a \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0637\u0651\u0628\u064a\u0651\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0651\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 12\\2\\2024 \u0628\u0631\u0642\u0645 194\\\u0635.<\/p>\n<p><strong>\u0623\u062e\u0630 \u0639\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u062f\u0651\u0645 \u0648\u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0651\u0629:<\/strong><\/p>\n<p>\u062c\u064f\u0645\u0650\u0639\u064e \u0642\u064f\u0631\u0627\u0628\u0629 5 \u0645\u0644 \u0645\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0645\u0646 \u0643\u0644 \u0633\u064a\u0651\u062f\u0629\u060c \u0648\u0648\u064f\u0636\u0650\u0639\u064e\u062a \u0641\u064a \u0623\u0646\u0628\u0648\u0628 \u062c\u0627\u0641 \u0648\u062b\u064f\u0641\u0651\u0644\u064e\u062a \u0627\u0644\u0639\u064a\u0651\u0646\u0629 \u0628\u0642\u0648\u0651\u0629 \u062a\u062b\u0641\u064a\u0644 \u0646\u0633\u0628\u064a\u0651\u0629 \u062a\u0639\u0627\u062f\u0644 1000xg \u0644\u0645\u062f\u0651\u0629 10 \u062f\u0642\u0627\u0626\u0642\u060c \u0628\u0639\u062f\u0647\u0627 \u062a\u0645\u0651 \u0641\u0635\u0644 \u0627\u0644\u0639\u064a\u0651\u0646\u0629 \u0648\u0627\u0644\u0627\u062d\u062a\u0641\u0627\u0638 \u0628\u0627\u0644\u0645\u0635\u0644 serum \u0641\u064a \u0623\u0646\u0627\u0628\u064a\u0628 \u0627\u0628\u0646\u062f\u0648\u0631\u0641 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 -20 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0651\u0629 \u0644\u062d\u064a\u0646 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629.<\/p>\n<p>\u0639\u0627\u064a\u0631\u0646\u0627 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0644\u0648\u0646\u064a\u0651\u0629 colorimetric assay \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0643\u064a\u062a \u0645\u0646 \u0634\u0631\u0643\u0629 Roche Cobas \u0627\u0644\u0633\u0648\u064a\u0633\u0631\u064a\u0651\u0629 \u0648\u0641\u0642 \u062a\u0639\u0644\u064a\u0645\u0627\u062a \u0627\u0644\u0634\u0651\u0631\u0643\u0629 \u0627\u0644\u0645\u064f\u0635\u0646\u0651\u0650\u0639\u0629. \u0623\u062c\u0631\u064a\u0646\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0641\u064a \u0645\u062e\u062a\u0628\u0631 \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0648\u0637\u0646\u064a \u0627\u0644\u062c\u0627\u0645\u0639\u064a \u0641\u064a \u062f\u0645\u0634\u0642\u061b \u0648\u0634\u0645\u0644\u062a \u0627\u0644\u0623\u062c\u0647\u0632\u0629 \u0627\u0644\u0645\u064f\u0633\u062a\u064e\u062e\u062f\u0645\u0629 \u0645\u0627 \u064a\u0644\u064a: \u062c\u0647\u0627\u0632 \u0643\u064a\u0645\u064a\u0627\u0621 \u0622\u0644\u064a \u0645\u0646 \u0634\u0631\u0643\u0629 Roche Cobas \u0627\u0644\u0633\u0648\u064a\u0633\u0631\u064a\u0651\u0629.<\/p>\n<p><strong>\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629:<\/strong><\/p>\n<p>\u0627\u0633\u062a\u064f\u062e\u062f\u0650\u0645 \u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u062d\u0632\u0645\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 SPSS \u0627\u0644\u0625\u0635\u062f\u0627\u0631 26 \u0644\u0625\u0646\u062c\u0627\u0632 \u0643\u0627\u0645\u0644 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629\u060c \u0648\u0639\u0628\u0651\u0631\u0646\u0627 \u0639\u0646 \u0627\u0644\u0642\u064a\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 (\u0627\u0644\u0645\u062a\u0648\u0633\u0651\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a\u0651 \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a\u0651)\u060c \u0648\u0642\u0648\u0631\u0650\u0646\u064e\u062a \u0627\u0644\u0642\u064a\u0645 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631Mann-Whitney\u060c \u0623\u0645\u0651\u0627 \u0627\u062e\u062a\u0628\u0627\u0631 ANOVA Test \u0645\u062a\u0628\u0648\u0639\u0627\u064b \u0628\u0627\u062e\u062a\u0628\u0627\u0631 Tukey HSD Test \u0641\u0642\u062f \u0627\u0633\u062a\u064f\u062e\u062f\u0650\u0645 \u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0628\u064a\u0646 \u0645\u062a\u0648\u0633\u0637\u0627\u062a \u062b\u0644\u0627\u062b \u0645\u062c\u0645\u0648\u0639\u0627\u062a. \u0628\u064a\u0646\u0645\u0627 \u062f\u064f\u0631\u0650\u0633\u064e\u062a \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u0633\u0628\u064a\u0631\u0645\u0627\u0646\u060c \u0648\u0627\u0639\u062a\u064f\u0645\u0650\u062f\u064e\u062a \u0642\u064a\u0645\u0629 P-value &lt; 0.05 \u0644\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0643\u0642\u064a\u0645\u0629\u064d \u064a\u064f\u0639\u062a\u064e\u062f\u0651 \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0646\u0651\u062a\u0627\u0626\u062c <\/strong><strong>Results<\/strong><\/p>\n<p><strong>\u062a\u0648\u0635\u064a\u0641 \u0639\u064a\u0651\u0646\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629:<\/strong><\/p>\n<p>\u0643\u0627\u0646 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0623\u0639\u0645\u0627\u0631 \u0645\u064f\u0645\u0627\u062b\u0644\u0629 (p-value = 0.668) \u062d\u064a\u062b \u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u0639\u0645\u0631 \u0627\u0644\u0645\u062a\u0637\u0648\u0651\u0639\u0627\u062a 52 \u0639\u0627\u0645\u0627\u064b \u062a\u0642\u0631\u064a\u0628\u0627\u064b\u060c \u0648\u0644\u0645 \u064a\u0643\u0646 \u0647\u0646\u0627\u0643 \u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0645\u0646 \u062d\u064a\u062b \u0645\u0624\u0634\u0651\u0631 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (p-value = 0.247) body mass index (BMI) \u0628\u0645\u062a\u0648\u0633\u0637 28 \u0643\u063a\\\u0645<sup>2 <\/sup>\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u064829 \u0643\u063a\\\u0645<sup>2 <\/sup>\u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629. \u062a\u0645\u0627\u062b\u0644\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u0627\u0646 \u0623\u064a\u0636\u0627\u064b \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u062a\u062f\u062e\u064a\u0646 (p-value = 0.612) \u0625\u0630 \u0625\u0646\u0651 \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u062a\u0637\u0648\u0639\u0627\u062a \u0644\u0645 \u064a\u0643\u0646\u0651 \u0645\u064f\u062f\u062e\u0651\u0646\u0627\u062a\u060c \u0648\u0643\u0627\u0646\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0627\u062c\u062a\u0645\u0627\u0639\u064a\u0651\u0629 \u0648\u0627\u0644\u0627\u0642\u062a\u0635\u0627\u062f\u064a\u0651\u0629 (\u062a\u0628\u0639\u0627\u064b \u0644\u0625\u0641\u0627\u062f\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a) \u0645\u062a\u0648\u0627\u0641\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646\u060c \u0648\u062a\u0643\u0645\u0646 \u0623\u0647\u0645\u064a\u0629 \u0630\u0644\u0643 \u0641\u064a \u0625\u0644\u063a\u0627\u0621 \u062a\u0623\u062b\u064a\u0631 \u062a\u0641\u0627\u0648\u062a \u0627\u0644\u0638\u0631\u0648\u0641 \u0627\u0644\u0645\u0639\u064a\u0634\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062a\u0637\u0648\u0639\u0627\u062a \u0648\u0627\u0644\u062a\u064a \u062a\u0646\u0639\u0643\u0633 \u0639\u0644\u0649 \u0627\u0644\u0648\u0627\u0631\u062f \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0645\u0646 \u0627\u0644\u062d\u062f\u064a\u062f \u0648\u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062f \u0641\u064a \u0627\u0644\u062f\u0645 \u0644\u062f\u064a\u0647\u0646. \u00a0\u0623\u0645\u0651\u0627 \u0646\u0633\u0628\u0629 \u0627\u0644\u0646\u0651\u0633\u0627\u0621 \u0627\u0644\u0648\u0644\u0648\u062f\u0627\u062a \u0641\u0642\u062f \u0643\u0627\u0646\u062a \u0623\u0639\u0644\u0649 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u0629 (P-value = 0.037).<\/p>\n<p><strong>\u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a:<\/strong><\/p>\n<p>\u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 40 \u0627\u0645\u0631\u0623\u0629 \u0645\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0645\u064f\u0634\u062e\u0651\u064e\u0635 \u062d\u062f\u064a\u062b\u0627\u064b \u0639\u0628\u0631 \u0625\u062c\u0631\u0627\u0621 \u062e\u0632\u0639\u0629 \u0646\u0633\u064a\u062c\u064a\u0651\u0629\u060c \u0648\u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 1 \u062a\u0648\u0632\u0651\u064f\u0639\u0647\u0646\u0651\u064e \u0648\u0641\u0642\u0627\u064b \u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645 Tumor grade \u0648\u062d\u062c\u0645\u0647 Tumor size (T) \u0648\u062d\u0627\u0644\u0629 \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0651\u0629 the regional lymph nodes status (N) \u0648\u0627\u0644\u0646\u0651\u0642\u0627\u0626\u0644 \u0627\u0644\u0628\u0639\u064a\u062f\u0629 distant metastasis (M) \u0648\u0627\u0644\u062a\u0651\u0635\u0646\u064a\u0641 \u062d\u0633\u0628 TNM Staging \u062d\u0633\u0628 American Joint Committee on Cancer (AJCC 6th Edition) \u060c \u0648\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629 \u0648\u0647\u064a \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 Estrogen receptor (ER)\u060c \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0628\u0631\u0648\u062c\u0633\u062a\u0631\u0648\u0646 Progesterone receptor (PR) \u0648\u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0648\u064a\u0651 \u0627\u0644\u0628\u0634\u0631\u064a\u0651 Human epidermal growth factor receptor 2 (HER2).<\/p>\n<table>\n<tbody>\n<tr>\n<td style=\"text-align: center;\" colspan=\"5\" width=\"519\"><strong>\u0627\u0644\u062c\u062f\u0648\u0644 (1): \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\"><strong>\u0648\u0631\u0645 \u0645\u062a\u0642\u062f\u0645 \u0627\u0644\u062f\u0631\u062c\u0629<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\"><strong>\u0648\u0631\u0645 \u0645\u0646\u062e\u0641\u0636 \u0627\u0644\u062f\u0631\u062c\u0629<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\">21 (74.5)<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\">19 (52.5)<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u062d\u062c\u0645 \u0627\u0644\u0648\u0631\u0645 <\/strong><strong>T<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"112\"><strong>T1<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>T2<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\"><strong>T3<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>T4<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\">17 (42.5)<\/td>\n<td style=\"text-align: center;\" width=\"113\">15 (37.5)<\/td>\n<td style=\"text-align: center;\" width=\"112\">7 (17.5)<\/td>\n<td style=\"text-align: center;\" width=\"113\">1 (2.5)<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u062d\u0627\u0644\u0629 \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 <\/strong><strong>N<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"112\"><strong>N0<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>N1<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\"><strong>N2<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>N3<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\">5 (12.5)<\/td>\n<td style=\"text-align: center;\" width=\"113\">17 (42.5)<\/td>\n<td style=\"text-align: center;\" width=\"112\">16 (40)<\/td>\n<td style=\"text-align: center;\" width=\"113\">2 (5)<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u0627\u0644\u0646\u0642\u0627\u0626\u0644 \u0627\u0644\u0628\u0639\u064a\u062f\u0629 <\/strong><strong>M<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\"><strong>M0<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\"><strong>M1<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\">28 (70)<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"225\">12 (30)<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u062f<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u0627\u0644\u062a\u0635\u0646\u064a\u0641 \u062d\u0633\u0628 <\/strong><strong>TNM Staging<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"112\"><strong>Stage 1<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>Stage 2<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\"><strong>Stage 3<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>Stage 4<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\">2 (5)<\/td>\n<td style=\"text-align: center;\" width=\"113\">14 (35)<\/td>\n<td style=\"text-align: center;\" width=\"112\">12 (30)<\/td>\n<td style=\"text-align: center;\" width=\"113\">12 (30)<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u062d\u0627\u0644\u0629 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 <\/strong><strong>ER<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"112\"><strong>ER-<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>ER+<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\"><strong>ER++<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>ER+++<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\">10 (25)<\/td>\n<td style=\"text-align: center;\" width=\"113\">17 (42.5)<\/td>\n<td style=\"text-align: center;\" width=\"112\">5 (12.5)<\/td>\n<td style=\"text-align: center;\" width=\"113\">8 (20)<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u062d\u0627\u0644\u0629 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0628\u0631\u0648\u062c\u0633\u062a\u0631\u0648\u0646 <\/strong><strong>PR<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"112\"><strong>PR-<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>PR+<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\"><strong>PR++<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>PR+++<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\">15 (37.5)<\/td>\n<td style=\"text-align: center;\" width=\"113\">15 (37.5)<\/td>\n<td style=\"text-align: center;\" width=\"112\">3 (7.5)<\/td>\n<td style=\"text-align: center;\" width=\"113\">7 (17.5)<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"69\"><strong>\u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"4\" width=\"450\"><strong>\u062d\u0627\u0644\u0629 \u0645\u0633\u062a\u0642\u0628\u0644 <\/strong><strong>HER2<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"112\"><strong>HER2-<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>HER2+<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\"><strong>HER2++<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"113\"><strong>HER2+++<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"69\"><strong>\u0627\u0644\u0639\u062f\u062f (%)<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"112\">20 (50)<\/td>\n<td style=\"text-align: center;\" width=\"113\">2 (5)<\/td>\n<td style=\"text-align: center;\" width=\"112\">4 (10)<\/td>\n<td style=\"text-align: center;\" width=\"113\">14 (35)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0641\u0631\u0642 \u0641\u064a \u0645\u062a\u0648\u0633\u0637\u0627\u062a \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0644\u0644\u062d\u062f\u064a\u062f \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 (\u0627\u0644\u062d\u0627\u0644\u0629 \u0648\u0627\u0644\u0634\u0627\u0647\u062f) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0627\u0646 \u0648\u064a\u062a\u0646\u064a Mann-Whitney U test\u060c \u0644\u0645 \u0646\u062c\u062f \u0641\u0631\u0642\u0627\u064b \u0630\u0627 \u0642\u064a\u0645\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 P-value=0.108 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u0629 \u0643\u0645\u0627 \u0647\u0648 \u0645\u064f\u0648\u0636\u0651\u064e\u062d \u0641\u064a \u0627\u0644\u0634\u0643\u0644 (1).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2030 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-300x205.png\" alt=\"\" width=\"504\" height=\"344\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-300x205.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-768x524.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1.png 791w\" sizes=\"auto, (max-width: 504px) 100vw, 504px\" \/><\/p>\n<p>\u0644\u062f\u0649 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062f \u0628\u064a\u0646 \u062b\u0644\u0627\u062b \u0645\u062c\u0645\u0648\u0639\u0627\u062a (\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u0629\u060c \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0627\u0644\u0645\u064f\u062a\u0642\u062f\u0651\u0645\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636 high grade\u060c \u0648\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636 low grade) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 ANOVA test \u0645\u062a\u0628\u0648\u0639\u0627\u064b \u0628\u0627\u062e\u062a\u0628\u0627\u0631 \u00a0Tukey HSD (\u0627\u0644\u0634\u0643\u0644 2)\u060c \u0648\u062c\u062f\u0646\u0627 \u0641\u0631\u0642\u0627\u064b \u0630\u0627 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 P-value=0.003 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062b\u0629\u060c \u0625\u0630 \u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0651\u0637 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0627\u0644\u0648\u0631\u0645 \u0645\u062a\u0642\u062f\u0651\u0645 \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0647\u0648 \u0627\u0644\u0623\u0639\u0644\u0649. \u0648\u0628\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u062a\u0648\u0633\u0651\u0637\u0627\u062a \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0628\u064a\u0646 \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0639\u0644\u0649 \u062d\u062f\u0629\u060c \u0648\u064f\u062c\u0650\u062f\u064e \u0641\u0631\u0642 \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 P-value=0.009 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u0629 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0648\u0631\u0645 \u0630\u064a \u062f\u0631\u062c\u0629 \u0645\u0646\u062e\u0641\u0636\u0629\u060c \u0625\u0630 \u0648\u062c\u062f \u0623\u0646\u0651 \u0645\u062a\u0648\u0633\u0651\u0637 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0644\u062f\u0649 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0635\u062d\u064a\u062d\u0627\u062a \u0623\u0639\u0644\u0649 \u0645\u0646\u0647 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0648\u0631\u0645 \u0630\u064a \u062f\u0631\u062c\u0629 \u0645\u0646\u062e\u0641\u0636\u0629. \u0643\u0645\u0627 \u0648\u062c\u062f \u0641\u0631\u0642 \u064a\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b P-value=0.004 \u0628\u064a\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0645\u064f\u062a\u0642\u062f\u0651\u0645\u0629 \u0648\u0630\u0648\u0627\u062a \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629\u060c \u0641\u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0651\u0637 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0623\u0639\u0644\u0649 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0627\u0644\u0648\u0631\u0645 \u0630\u064a \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0645\u064f\u062a\u0642\u062f\u0651\u0645\u0629 \u0645\u0646\u0647 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0623\u0642\u0644 \u062f\u0631\u062c\u0629.<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2031 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-300x205.png\" alt=\"\" width=\"468\" height=\"320\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-300x205.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-768x526.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2.png 830w\" sizes=\"auto, (max-width: 468px) 100vw, 468px\" \/><\/p>\n<p>\u0648\u062f\u0631\u0633\u0646\u0627 \u0623\u064a\u0636\u0627\u064b \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0648\u0627\u0644\u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0644\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0639\u0627\u0645\u0644 Spearman (\u062c\u062f\u0648\u0644 2)<strong>\u061b <\/strong>\u0648\u064f\u062c\u0650\u062f\u064e \u0627\u0631\u062a\u0628\u0627\u0637\u064c \u0630\u0648 \u0642\u064a\u0645\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 P-value=0.011 \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0641\u064a \u0627\u0644\u0645\u0635\u0644 \u0639\u0646\u062f \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0648\u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645 grade \u0648\u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0637\u0631\u062f\u064a\u0651\u0629 \u0623\u064a \u064a\u0632\u062f\u0627\u062f \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062d\u062f\u064a\u062f \u0641\u064a \u0627\u0644\u062f\u0651\u0645 \u0628\u0627\u0632\u062f\u064a\u0627\u062f \u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a.<br \/>\n\u0628\u064a\u0646\u0645\u0627 \u0644\u0645 \u064a\u0648\u062c\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u064a\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u064a\u0646 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0648\u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645 \u0648\u062d\u062c\u0645\u0647 \u0648\u062d\u0627\u0644\u0629 \u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0651\u0629 \u0648\u0648\u062c\u0648\u062f \u0623\u0648 \u063a\u064a\u0627\u0628 \u0627\u0644\u0646\u0651\u0642\u0627\u0626\u0644 \u0648\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u062d\u0633\u0628 TNM staging. \u0648\u0623\u062e\u064a\u0631\u0627\u064b \u0644\u0645 \u064a\u0648\u062c\u062f \u0623\u064a \u0627\u0631\u062a\u0628\u0627\u0637 \u064a\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0628\u064a\u0646 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a \u0648\u0627\u0644\u062a\u0651\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0648\u0631\u0645\u064a\u0651\u0629 \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2032 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-205x300.png\" alt=\"\" width=\"300\" height=\"439\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-205x300.png 205w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3.png 427w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Discussion<\/strong><\/p>\n<p>\u062a\u0634\u064a\u0631 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0627\u0644\u062a\u064a \u0644\u0627\u062d\u0638\u0646\u0627\u0647\u0627 \u0641\u064a \u0645\u0633\u062a\u0648\u0649 \u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644 \u062a\u0628\u0639\u0627\u064b \u0644\u062f\u0631\u062c\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u062d\u062f\u064a\u062b \u0627\u0644\u062a\u0651\u0634\u062e\u064a\u0635 \u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u062a\u0648\u0627\u0632\u0646 \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062d\u062f\u064a\u062f \u0641\u064a \u0627\u0644\u0639\u0636\u0648\u064a\u0651\u0629 \u0628\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0651\u0629 \u0625\u0630 \u064a\u0624\u062f\u0651\u064a \u0631\u062f\u0651 \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a \u0627\u0644\u0645\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0627\u0644\u0623\u0630\u064a\u0651\u0629 \u0627\u0644\u062a\u064a \u064a\u062d\u062f\u062b\u0647\u0627 \u0648\u062c\u0648\u062f \u0627\u0644\u0633\u0651\u0631\u0637\u0627\u0646 \u0625\u0644\u0649 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0628\u0639\u0636 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064f\u0633\u0627\u0647\u0645\u0629 \u0641\u064a \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062d\u062f\u064a\u062f \u0648\u062a\u0648\u0627\u0632\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a\u0647 \u0641\u064a \u0627\u0644\u062f\u0645 \u0645\u062b\u0644 \u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0647\u064a\u0628\u0633\u064a\u062f\u064a\u0646 hepcidin \u0627\u0644\u0643\u0628\u062f\u064a\u060c \u0625\u0630 \u0625\u0646\u0651 \u0625\u0641\u0631\u0627\u0632\u0647 \u064a\u062a\u0623\u062b\u0631 \u0628\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651\u0629 \u0648\u064a\u064f\u062d\u0631\u0651\u064e\u0636 \u0628\u0625\u0641\u0631\u0627\u0632 \u0628\u0639\u0636 \u0627\u0644\u0633\u0651\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0645\u062b\u0644 \u0627\u0644\u0627\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646 6 Interleukin-6 (IL-6) [9]. \u0648\u0628\u0633\u064a\u0627\u0642 \u0630\u0644\u0643\u060c \u0648\u064f\u062c\u062f \u0623\u0646\u0651 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0645\u0646 IL-6 \u0627\u0631\u062a\u0628\u0637\u062a \u0645\u0639 \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0644\u0625\u0646\u0630\u0627\u0631 \u0627\u0644\u0623\u0641\u0636\u0644 good prognostic variables \u0639\u0646\u062f \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0623\u0647\u0645\u0651\u064f\u0647\u0627 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0642\u0644 \u0644\u0644\u0648\u0631\u0645 [10]\u060c \u0623\u064a \u0623\u0646\u0651 \u0627\u0644\u0648\u0631\u0645 \u0630\u0627 \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0627\u0644\u0645\u064f\u0646\u062e\u0641\u0636\u0629 \u064a\u062a\u0631\u0627\u0641\u0642 \u0645\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0639\u0627\u0644\u064a\u0629 \u0645\u0646 IL-6 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0623\u0639\u0644\u0649 \u0645\u0646 \u0627\u0644\u0647\u064a\u0628\u0633\u064a\u062f\u064a\u0646 \u0627\u0644\u0630\u064a \u064a\u0624\u062f\u064a \u0644\u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0641\u0633\u0651\u0650\u0631 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0645\u0646\u062e\u0641\u0636 \u0644\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0648\u0631\u0645 \u0630\u064a \u062f\u0631\u062c\u0629 \u0645\u0646\u062e\u0641\u0636\u0629 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0635\u062d\u064a\u062d\u0627\u062a (p-value = 0.009). \u0643\u0645\u0627 \u0642\u062f \u064a\u0628\u064a\u0651\u0646 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0630\u0644\u0643 \u0627\u0644\u0641\u0627\u0631\u0642 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0627\u0644\u0648\u0631\u0645 \u0645\u064f\u062a\u0642\u062f\u0651\u0650\u0645 \u0627\u0644\u062f\u0631\u062c\u0629 \u0648\u0627\u0644\u0635\u062d\u064a\u062d\u0627\u062a \u0625\u0644\u0649 \u0636\u0639\u0641 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0651\u0629 \u0644\u062f\u064a\u0647\u0646\u0651\u064e. \u0648\u0642\u062f \u0623\u0634\u0627\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u0633\u0627\u0628\u0642\u0629 \u0625\u0644\u0649 \u0623\u0646\u0651 \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0627\u0644\u0645\u064f\u062a\u0642\u062f\u0651\u0645\u0629 \u0645\u0646 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646\u062f \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0644\u0645 \u062a\u0631\u062a\u0628\u0637 \u0645\u0639 \u0627\u0644\u062a\u0651\u0639\u0628\u064a\u0631 \u0639\u0646 IL-6 [11]\u060c \u0623\u064a \u0623\u0646\u0651\u0647 \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0630\u064a \u0627\u0644\u062f\u0651\u0631\u062c\u0629 \u0627\u0644\u0623\u0639\u0644\u0649 \u0642\u062f \u064a\u0643\u0648\u0646 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0647\u064a\u0628\u0633\u064a\u062f\u064a\u0646 \u0623\u0642\u0644 \u0641\u064a\u0643\u0648\u0646 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a \u0623\u0639\u0644\u0649\u060c \u0648\u0647\u0630\u0627 \u0645\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u062d\u064a\u062b \u062a\u0631\u0627\u0641\u0642 \u0627\u0644\u0648\u0631\u0645 \u0645\u062a\u0642\u062f\u0651\u0645 \u0627\u0644\u062f\u0631\u062c\u0629 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0628\u0645\u0633\u062a\u0648\u0649 \u0623\u0639\u0644\u0649 \u0645\u0646 \u0627\u0644\u062d\u062f\u064a\u062f \u0641\u064a \u0627\u0644\u0645\u0635\u0644. \u0648\u0628\u0645\u0639\u0646\u0649 \u0622\u062e\u0631 \u0642\u062f \u062a\u0631\u062a\u0628\u0637 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0646 \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a \u0639\u0646\u062f \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0645\u0639 \u0625\u0646\u0630\u0627\u0631 \u0623\u0633\u0648\u0623 \u0644\u0644\u0645\u0631\u0636 Poor prognosis\u060c \u0648\u0647\u0630\u0627 \u0645\u0627 \u0623\u0634\u0627\u0631\u062a \u0625\u0644\u064a\u0647 \u062f\u0631\u0627\u0633\u0629 \u0633\u0627\u0628\u0642\u0629 [12]\u060c \u0639\u0646\u062f \u0645\u062a\u0627\u0628\u0639\u0629 \u0645\u0631\u064a\u0636\u0627\u062a \u0635\u064a\u0646\u064a\u0651\u0627\u062a \u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0642\u0627\u0639\u062f\u064a \u0628\u0639\u062f \u062a\u0642\u0633\u064a\u0645\u0647\u0646\u0651 \u0625\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0648\u0641\u0642 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629\u060c \u0648\u0628\u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u062a\u0631\u0627\u0641\u0642\u062a \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0646 \u0627\u0644\u062d\u062f\u064a\u062f \u0645\u0639 \u0632\u0645\u0646 \u0628\u064f\u0642\u064a\u0627 \u0623\u0642\u0644 overall survival (OS) \u0648\u0632\u0645\u0646 \u0628\u064f\u0642\u064a\u0627 \u062f\u0648\u0646 \u0645\u0631\u0636 \u0623\u0642\u0644 disease-free survival (DFS).<br \/>\n\u0641\u064a\u0645\u0627 \u064a\u062e\u0635\u0651 \u0639\u062f\u0645 \u0627\u062e\u062a\u0644\u0627\u0641 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629\u060c \u062a\u0648\u0627\u0641\u0642\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0644\u064a\u0644\u064a\u0651\u0629 \u062a\u0644\u0648\u064a\u0651\u0629 meta-analysis \u0623\u062c\u0631\u0627\u0647\u0627 Sanagoo A\u00a0 \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0639\u0627\u0645 2020 [4]\u060c \u0625\u0630 \u0625\u0646\u0651\u0647\u0645 \u0648\u0628\u062c\u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u0639\u062f\u0651\u0629 \u062f\u0631\u0627\u0633\u0627\u062a \u0633\u0627\u0628\u0642\u0629 \u0644\u0645 \u064a\u062c\u062f\u0648\u0627 \u0641\u0627\u0631\u0642\u0627\u064b \u0645\u0639\u0646\u0648\u064a\u0651\u0627\u064b \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062d\u062f\u064a\u062f \u0641\u064a \u0627\u0644\u0645\u0635\u0644 \u0644\u062f\u0649 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0648\u063a\u064a\u0631 \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0647 \u0648\u0630\u0644\u0643 \u0639\u0646\u062f \u0627\u0644\u062a\u0639\u0627\u0645\u0644 \u0645\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0651\u0629 \u0639\u0644\u0649 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0641\u0631\u0639\u064a\u0651\u0629 \u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u062d\u062f\u064a\u062b\u0627\u062a \u0627\u0644\u062a\u0651\u0634\u062e\u064a\u0635. \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0651\u0629 \u0628\u0639\u0636 \u0627\u0644\u0645\u062d\u062f\u062f\u0627\u062a\u061b \u0623\u0648\u0644\u0627\u064b\u060c \u0639\u062f\u062f \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0642\u0644\u064a\u0644\u060c \u0648\u062b\u0627\u0646\u064a\u0627\u064b\u060c \u0639\u062f\u0645 \u0645\u0642\u0627\u064a\u0633\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0647\u064a\u0628\u0633\u064a\u062f\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0635\u0644.<\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/p>\n<p>\u064a\u0634\u064a\u0631 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0646 \u0627\u0644\u0648\u0631\u0645 \u0645\u0639 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0627\u0644\u0623\u0639\u0644\u0649 \u0644\u0644\u062d\u062f\u064a\u062f \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u064f\u0634\u062e\u0651\u0635\u0627\u062a \u062d\u062f\u064a\u062b\u0627\u064b \u0625\u0644\u0649 \u062f\u0648\u0631 \u0645\u064f\u062d\u062a\u064e\u0645\u0644 \u0644\u0644\u062d\u062f\u064a\u062f \u0644\u062f\u0649 \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0651\u0629 \u0645\u0645\u0651\u0627 \u064a\u0633\u062a\u062f\u0639\u064a \u0623\u062e\u0630 \u0630\u0644\u0643 \u0628\u0639\u064a\u0646 \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 \u0644\u062f\u0649 \u0648\u0636\u0639 \u0627\u0644\u062e\u0637\u0651\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0651\u0629 \u0648\u0645\u062a\u0627\u0628\u0639\u0629 \u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0629.<br \/>\n\u0644\u0627 \u0628\u062f\u0651 \u0645\u0646 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0649 \u0623\u0639\u062f\u0627\u062f \u0623\u0643\u0628\u0631 \u0645\u0646 \u0645\u064f\u062e\u062a\u064e\u0644\u064e\u0641 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0641\u0631\u0639\u064a\u0651\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0644\u0641\u0647\u0645 \u0623\u0639\u0645\u0642 \u0644\u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0645\u064f\u0639\u0642\u0651\u062f\u0629 \u0628\u064a\u0646 \u0627\u0644\u062d\u062f\u064a\u062f \u0648\u0627\u0644\u062e\u0644\u064a\u0651\u0629 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0651\u0629 \u0628\u0627\u062e\u062a\u0644\u0627\u0641 \u0623\u0646\u0645\u0627\u0637\u0647\u0627 \u0645\u0646 \u062c\u0647\u0629 \u0648\u0641\u0647\u0645 \u062a\u0623\u062b\u064a\u0631 \u062a\u0644\u0643 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0639\u0644\u0649 \u0627\u0633\u062a\u062a\u0628\u0627\u0628 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062f \u0641\u064a \u0627\u0644\u0639\u0636\u0648\u064a\u0651\u0629 \u0645\u0646 \u062c\u0647\u0629 \u0623\u062e\u0631\u0649\u060c\u00a0 \u00a0\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0644\u0636\u0631\u0648\u0631\u0629 \u0645\u064f\u062a\u0627\u0628\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u062a\u0642\u0635\u0651\u064a \u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0644\u0644\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0635\u0644\u064a \u0639\u0646\u062f \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a.<\/p>\n<p><strong>\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a <\/strong><strong>List of abbreviations<\/strong><\/p>\n<table width=\"319\">\n<tbody>\n<tr>\n<td width=\"64\">ROS<\/td>\n<td width=\"255\">\u00a0reactive oxygen species<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">BMI<\/td>\n<td width=\"255\">\u00a0body mass index<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">T<\/td>\n<td width=\"255\">\u00a0Tumor size<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">N<\/td>\n<td width=\"255\">\u00a0the regional lymph nodes status<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">M<\/td>\n<td width=\"255\">\u00a0distant metastasis<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">AJCC<\/td>\n<td width=\"255\">\u00a0American Joint Committee on Cancer<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">ER<\/td>\n<td width=\"255\">\u00a0Estrogen receptor<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">PR<\/td>\n<td width=\"255\">\u00a0Progesterone receptor<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">HER2<\/td>\n<td width=\"255\">\u00a0Human epidermal growth factor receptor 2<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">IL-6<\/td>\n<td width=\"255\">\u00a0Interleukin-6<\/td>\n<\/tr>\n<tr>\n<td width=\"64\">OS<\/td>\n<td width=\"255\">\u00a0overall survival<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 <\/strong><strong>Ethics<\/strong><\/p>\n<p><strong>approval and consent to participate<\/strong><\/p>\n<p>\u062d\u0635\u0644\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0645\u062c\u0644\u0633 \u0623\u062e\u0644\u0627\u0642\u064a\u0651\u0627\u062a \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0637\u0651\u0628\u064a\u0651\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0651\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 12\\2\\2024 \u0628\u0631\u0642\u0645 194\\\u0635.<\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong><strong>Conflict of interests<\/strong><\/p>\n<p>\u064a\u064f\u0642\u0650\u0631\u0651 \u062c\u0645\u064a\u0639 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062a\u0636\u0627\u0631\u0628\u064d \u0641\u064a \u0627\u0644\u0645\u0635\u0627\u0644\u062d \u0641\u064a\u0645\u0627 \u0628\u064a\u0646\u0647\u0645.<\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong><strong>Funding<\/strong><\/p>\n<p>\u0645\u0648\u0651\u0644\u062a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0627\u0644\u0628\u062d\u062b \u062c\u0632\u0626\u064a\u0627\u064b.<\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong><strong>Authors\u2019 contributions<\/strong><\/p>\n<p>\u0644\u0645\u0649 \u0627\u0644\u062d\u062f\u0627\u062f: \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0648\u062a\u0637\u0648\u064a\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646\u060c \u0648\u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a\u060c \u0648\u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a\u060c \u0648\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0645\u062e\u0637\u0648\u0637\u0627\u062a.<\/p>\n<p>\u0631\u0646\u0648\u0629 \u0627\u0644\u0633\u064a\u062f: \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0648\u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a\u060c \u0648\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0645\u062e\u0637\u0648\u0637\u0627\u062a.<\/p>\n<p>\u0645\u0627\u0647\u0631 \u0633\u064a\u0641\u0648: \u062a\u0637\u0648\u064a\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646\u060c \u0648\u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a.<\/p>\n<p><strong>\u0627\u0644\u0634\u0643\u0631 \u0648\u0627\u0644\u062a\u0642\u062f\u064a\u0631 <\/strong><strong>Acknowledgements<\/strong><\/p>\n<p>\u0646\u0648\u062f \u0623\u0646 \u0646\u0634\u0643\u0631 \u0627\u0644\u0637\u0627\u0642\u0645 \u0627\u0644\u0637\u0628\u0651\u064a \u0641\u064a \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0628\u064a\u0631\u0648\u0646\u064a \u0627\u0644\u062c\u0627\u0645\u0639\u064a \u0648\u0627\u0644\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0648\u0637\u0646\u064a \u0627\u0644\u062c\u0627\u0645\u0639\u064a \u0641\u064a \u062f\u0645\u0634\u0642.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u064a\u0639\u062f \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0633\u0651\u0631\u0637\u0627\u0646 \u0627\u0644\u0623\u0643\u062b\u0631 \u062a\u0634\u062e\u064a\u0635\u0627\u064b \u0639\u0646\u062f \u0627\u0644\u0646\u0651\u0633\u0627\u0621\u060c \u0628\u0646\u0633\u0628\u0629 \u062a\u0635\u0644 \u0625\u0644\u0649 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0639\u064f\u0634\u0652\u0631 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0634\u062e\u0651\u064e\u0635\u0629 \u0641\u064a \u0627\u0644\u0633\u0651\u0646\u0629 \u0645\u0646 \u0625\u062c\u0645\u0627\u0644\u064a&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=2029\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2035,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2029","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-157","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2029"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2029\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2035"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}