{"id":2036,"date":"2025-08-23T08:15:27","date_gmt":"2025-08-23T08:15:27","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2036"},"modified":"2025-08-23T08:15:27","modified_gmt":"2025-08-23T08:15:27","slug":"%d8%b9%d9%84%d8%a7%d9%82%d8%a9-%d8%a7%d9%84%d8%aa%d8%b9%d8%af%d9%91%d8%af-%d8%a7%d9%84%d8%b4%d9%91%d9%83%d9%84%d9%8a%d9%91-2044ag-%d9%81%d9%8a-%d8%ac%d9%8a%d9%86-il-13-%d8%a8%d8%a7%d9%84%d8%a3%d9%85","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2036","title":{"rendered":"\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a\u0651 +2044A>G \u0641\u064a \u062c\u064a\u0646 IL-13 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0651\u0629 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0627\u0644\u0633\u0648\u0631\u064a\u064a\u0646: \u062f\u0631\u0627\u0633\u0629 \u062d\u0627\u0644\u0629-\u0634\u0627\u0647\u062f"},"content":{"rendered":"<p><strong>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 <\/strong><strong>Introduction<\/strong><\/p>\n<p>\u062a\u0639\u0631\u0651\u0641 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0651\u0629 \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 \u062c\u0645\u0644\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0631\u062f\u0651 \u0641\u0639\u0644 \u0645\u0646\u0627\u0639\u064a\u0651 \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651 \u0634\u062f\u064a\u062f \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u062a\u0639\u0631\u0636 \u0644\u0645\u0633\u062a\u0636\u062f\u0627\u062a \u063a\u064a\u0631 \u0645\u0645\u0631\u0636\u0629 \u0641\u064a \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u062a\u062f\u0639\u0649 \u0628\u0627\u0644\u0645\u0633\u062a\u0623\u0631\u062c\u0627\u062a Allergens\u060c \u0648\u062a\u0634\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0643\u0644\u0651\u0627\u064b \u0645\u0646 \u0627\u0644\u0631\u0628\u0648 \u0627\u0644\u0623\u0631\u062c\u064a Allergic Asthma\u060c \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0623\u0646\u0641 \u0627\u0644\u0623\u0631\u062c\u064a Allergic Rhinitis\u060c \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u062a\u062c\u0627\u0647 \u0627\u0644\u0637\u0639\u0627\u0645 Food Allergy\u060c \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u062c\u0644\u062f \u0627\u0644\u062a\u0623\u062a\u0628\u064a Atopic Dermatitis\u060c \u0627\u0644\u0648\u0630\u0645\u0629 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 Angioedema\u060c \u0627\u0644\u0634\u0631\u0649 Urticaria\u060c \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0644\u0644\u062d\u0634\u0631\u0627\u062a \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 Insect and Drug Allergy\u060c \u0648 \u0627\u0644\u062a\u0623\u0642 Anaphylaxis\u060c (\u0631\u062f \u0641\u0639\u0644 \u0645\u0646\u0627\u0639\u064a \u062c\u0647\u0627\u0632\u064a \u062d\u0627\u062f\u0651 \u0627\u0633\u062a\u062c\u0627\u0628\u0629\u064b \u0644\u0644\u062a\u0639\u0631\u0636 \u0644\u0623\u062d\u062f \u0627\u0644\u0645\u0633\u062a\u0623\u0631\u062c\u0627\u062a \u0643\u0627\u0644\u0623\u0637\u0639\u0645\u0629 \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0648\u0627\u0644\u0633\u0645\u0648\u0645\u060c \u0648\u0642\u062f \u064a\u0643\u0648\u0646 \u0645\u0645\u064a\u062a\u0627\u064b) <sup>1<\/sup>.<\/p>\n<p>\u062a\u0634\u0643\u0651\u0644\u064f \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0623\u0643\u062b\u0631 \u0627\u0644\u0645\u0634\u0643\u0644\u0627\u062a \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0627\u0646\u062a\u0634\u0627\u0631\u0627\u064b \u062d\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645 \u0648 \u064a\u0628\u0644\u063a \u0645\u0639\u062f\u0644 \u0627\u0646\u062a\u0634\u0627\u0631\u0647\u0627 \u0646\u062d\u0648 \u0642\u0631\u0627\u0628\u0629 30% \u0645\u0646 \u0645\u062c\u0645\u0644 \u0627\u0644\u0633\u0643\u0627\u0646<sup>2<\/sup>\u060c \u0648\u0642\u062f \u0644\u0648\u062d\u0638 \u0627\u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u0643\u0628\u064a\u0631 \u0641\u064a \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0641\u064a \u0627\u0644\u062f\u0648\u0644 \u0627\u0644\u063a\u0631\u0628\u064a\u0629 \u0648\u0627\u0644\u062f\u0648\u0644 \u0627\u0644\u062a\u064a \u064a\u0633\u064a\u0637\u0631 \u0639\u0644\u064a\u0647\u0627 \u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u062d\u0636\u0631\u064a\u0629 \u0648\u0643\u0630\u0644\u0643 \u0627\u0644\u0623\u0645\u0631 \u0641\u064a \u0627\u0644\u062f\u0648\u0644 \u0630\u0627\u062a \u0627\u0644\u062f\u062e\u0644 \u0627\u0644\u0645\u0646\u062e\u0641\u0636 \u0648\u0627\u0644\u0645\u062a\u0648\u0633\u0637\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644\u0647\u0627 \u0645\u0646 \u0627\u0644\u062a\u062d\u062f\u064a\u0651\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0641\u064a \u0627\u0644\u0642\u0631\u0646 \u0627\u0644\u0648\u0627\u062d\u062f \u0648\u0627\u0644\u0639\u0634\u0631\u064a\u0646 \u0646\u0638\u0631\u0627\u064b \u0644\u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0627\u0644\u0633\u0644\u0628\u064a \u0639\u0644\u0649 \u062c\u0648\u062f\u0629 \u0648\u0646\u0648\u0639\u064a\u0629 \u062d\u064a\u0627\u0629 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0625\u0646\u062a\u0627\u062c\u064a\u062a\u0647\u0645 \u0645\u0645\u0627 \u064a\u062d\u0645\u0651\u0644 \u0627\u0644\u0645\u062c\u062a\u0645\u0639\u0627\u062a \u0623\u0639\u0628\u0627\u0621\u064b \u0648\u062e\u0633\u0627\u0626\u0631 \u0627\u0642\u062a\u0635\u0627\u062f\u064a\u0629 \u0636\u062e\u0645\u0629 <sup>3,4<\/sup>\u060c \u0648\u064a\u0628\u0631\u0632 \u0627\u0644\u0631\u0628\u0648 \u0643\u0623\u062d\u062f \u0623\u0643\u062b\u0631 \u0647\u0630\u0647 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u062a\u0623\u062b\u064a\u0631\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0635\u062c\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0648\u0625\u0646\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0630\u0644\u0643 \u0648\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0646\u062a\u0634\u0627\u0631\u0647 \u0627\u0644\u0648\u0627\u0633\u0639 (400 \u0645\u0644\u064a\u0648\u0646 \u0634\u062e\u0635 \u062d\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645) \u0641\u0625\u0646\u0647 \u064a\u0633\u0628\u0628 250 \u0623\u0644\u0641 \u062d\u0627\u0644\u0629 \u0648\u0641\u0627\u0629 \u0633\u0646\u0648\u064a\u0627\u064b \u0628\u062d\u0633\u0628 \u062a\u0642\u062f\u064a\u0631\u0627\u062a \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629<sup>2<\/sup>. \u0648\u0642\u062f \u0628\u064a\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0646 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0634\u0628\u0643\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0644\u0644\u0631\u0628\u0648 Global Asthma Network (GAN) \u0648\u0627\u0644\u062a\u064a \u0634\u0645\u0644\u062a \u0645\u0631\u0643\u0632\u064a\u0646 \u0631\u0626\u064a\u0633\u064a\u064a\u0646 \u0641\u064a \u0633\u0648\u0631\u064a\u0627 (3315 \u0645\u0634\u0627\u0631\u0643 \u0645\u0646 \u0645\u062d\u0627\u0641\u0638\u062a\u064a \u062f\u0645\u0634\u0642 \u0648\u0627\u0644\u0644\u0627\u0630\u0642\u064a\u0629)\u060c \u0623\u0646 \u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0630\u064a\u0646 \u0623\u0628\u0644\u063a\u0648\u0627 \u0639\u0646 \u0648\u062c\u0648\u062f \u0627\u0644\u0648\u0632\u064a\u0632 Wheezing \u062e\u0644\u0627\u0644 \u0627\u0644\u0623\u0634\u0647\u0631 \u0627\u0644\u0627\u062b\u0646\u064a \u0639\u0634\u0631 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0644\u063a\u062a 19.8%\u060c \u0641\u064a \u062d\u064a\u0646 \u0623\u0628\u0644\u063a 12.8% \u0645\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0639\u0646 \u0638\u0647\u0648\u0631 \u0623\u0639\u0631\u0627\u0636 \u0631\u0628\u0648 \u062d\u0627\u062f\u0629 Severe Asthma Symptom <sup>5<\/sup>.<\/p>\n<p>\u062a\u0646\u062f\u0631\u062c\u064f \u0627\u0644\u0623\u0645\u0631\u0627\u0636\u064f \u0627\u0644\u0623\u0631\u062c\u064a\u0651\u0629\u064f \u062a\u062d\u062a\u064e \u0627\u0644\u0646\u0645\u0637\u0650 \u0627\u0644\u0623\u0648\u0651\u0644\u0650 \u0645\u0646\u0652 \u062a\u0641\u0627\u0639\u0644\u0627\u062a\u0650 \u0641\u0631\u0637\u0650 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0651\u0629\u0650 Type I hypersensitivity\u060c \u0648 \u064a\u062a\u0637\u0648\u0651\u0631\u064f \u0647\u0630\u0627 \u0627\u0644\u0646\u0645\u0637\u064f \u0643\u063a\u064a\u0631\u0647\u0650 \u0645\u0646\u0652 \u0623\u0646\u0645\u0627\u0637\u0650 \u0641\u0631\u0637\u0650 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0651\u0629\u0650 \u0639\u0644\u0649 \u0645\u0631\u062d\u0644\u062a\u064a\u0646\u0650\u060c \u062a\u064f\u0639\u0631\u064e\u0641\u064f \u0627\u0644\u0623\u0648\u0644\u0649 \u0628\u0645\u0631\u062d\u0644\u0629\u0650 \u0627\u0644\u062a\u062d\u0633\u064a\u0633\u0650 Sensitization\u060c \u062d\u064a\u062b\u064f \u064a\u062a\u0639\u0631\u0651\u0636\u064f \u0627\u0644\u0641\u0631\u062f\u064f \u0644\u0645\u064f\u0633\u062a\u0623\u0631\u062c\u064d \u0645\u0627 \u0648\u0645\u0646\u0652 \u062b\u0645\u0651 \u062a\u0642\u0648\u0645\u064f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0642\u062f\u0651\u0645\u0629\u064f \u0644\u0644\u0645\u0633\u062a\u0636\u062f\u0651\u0650 Antigen presenting cells (APCs) \u00a0\u0628\u0627\u0644\u062a\u0642\u0627\u0645\u0650\u0647\u0650 \u0648\u062a\u0642\u062f\u064a\u0645\u0647\u0650 \u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0651\u0627\u062a \u0627\u0644\u062a\u0651\u0627\u0626\u064a\u0651\u0629\u0650 T-cells \u0641\u062a\u062d\u0631\u0651\u0636 \u062a\u0645\u0627\u064a\u0632\u064f \u0627\u0644\u062a\u0651\u0627\u0626\u064a\u0651\u0627\u062a\u064f \u0627\u0644\u0645\u0641\u0639\u0651\u0644\u0629\u064f \u0625\u0644\u0649 \u062e\u0644\u0627\u064a\u0627 \u062a\u0627\u0626\u064a\u0629\u064d \u0645\u0633\u0627\u0639\u062f\u0629\u064d T-helper cells \u0645\u0646 \u0627\u0644\u0646\u0645\u0637\u0650 \u0627\u0644\u062b\u0651\u0627\u0646\u064a Th2\u060c \u0648\u064a\u0646\u062a\u062c\u064f \u0639\u0646\u0652 \u0647\u0630\u0627 \u0627\u0644\u062a\u0641\u0651\u0639\u064a\u0644\u0650 \u0625\u0641\u0631\u0627\u0632\u064f \u0627\u0644\u0639\u062f\u064a\u062f\u0650 \u0645\u0646\u064e \u0627\u0644\u0625\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646\u0627\u062a Interleukins \u0645\u062b\u0644 IL-4\u060c IL-13\u060c IL-5\u060c IL-9\u060c IL-10. \u062a\u0624\u062f\u0651\u064a \u0647\u0630\u0647\u0650 \u0627\u0644\u0648\u0633\u0627\u0626\u0637\u064f \u0625\u0644\u0649 \u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u0646\u0645\u0637\u0650 \u0627\u0644\u0625\u0633\u0648\u064a\u0651 \u0644\u0644\u0623\u0636\u0651\u062f\u0627\u062f\u0650 \u0627\u0644\u0645\u0641\u0631\u0632\u0629\u0650 \u0645\u0646 \u0642\u0628\u0644\u0650 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0651\u0627\u062a\u0650 \u0627\u0644\u0628\u0627\u0626\u064a\u0651\u0629 B-cells \u0625\u0644\u0649 \u0623\u0636\u062f\u0627\u062f\u064d \u0645\u0646 \u0646\u0645\u0637\u0650 \u0627\u0644\u063a\u0644\u0648\u0628\u064a\u0648\u0628\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a E (IgE)\u060c \u062d\u064a\u062b \u062a\u0639\u0628\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u062f\u064a\u0646\u0629 Mast cells \u0648\u0627\u0644\u0623\u0633\u0633\u0627\u062a Basophils \u0639\u0644\u0649 \u0633\u0637\u0648\u062d\u0647\u0627 \u0639\u0646 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u064d \u0639\u0627\u0644\u064a\u0629\u0650 \u0627\u0644\u0623\u0644\u0641\u0629\u0650 \u0644\u0644\u0636\u0651\u062f IgE \u062a\u064f\u0639\u0631\u0641 \u0628\u0640 Fc\u03b5RI. \u064a\u0634\u0645\u0644 \u0637\u0648\u0631 \u0627\u0644\u062a\u062d\u0633\u064a\u0633 Sensitization Stage \u0627\u0631\u062a\u0628\u0627\u0637 \u0623\u0636\u062f\u0627\u062f IgE \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u0647\u0627 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u0644\u0641\u0629 \u062f\u0648\u0646 \u0623\u0646 \u064a\u0646\u062c\u0645 \u0639\u0646 \u0630\u0644\u0643 \u062a\u062d\u0631\u0651\u0631\u064c \u0644\u0623\u064a\u0651\u064d \u0645\u0646\u064e \u0627\u0644\u0648\u0633\u0627\u0626\u0637\u0650 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629\u0650\u060c \u0641\u064a \u062d\u064a\u0646\u0652 \u064a\u0637\u0644\u0642\u064f \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0651\u0627\u0646\u064a\u0629 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0627\u0633\u062a\u0641\u0639\u0627\u0644 Effector Stage\u060c \u0648\u0627\u0644\u0651\u062a\u064a \u062a\u064f\u0642\u0633\u064e\u0645\u064f \u0625\u0644\u0649 \u0637\u0648\u0631\u064e\u064a\u0646 \u0627\u062b\u0646\u064a\u0646\u061b \u064a\u064f\u0639\u0631\u064e\u0641\u064f \u0623\u0648\u0651\u0644\u0647\u064f\u0645\u0627 \u0628\u0637\u0648\u0631\u0650 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629\u0650 \u0627\u0644\u0641\u0648\u0631\u064a\u0651\u0629\u0650\u060c \u062d\u064a\u062b\u064f \u062a\u0624\u062f\u064a \u0645\u0639\u0627\u0648\u062f\u0629\u064f \u0627\u0644\u062a\u0639\u0631\u0636\u0651\u0650 \u0644\u0644\u0645\u0633\u062a\u0623\u0631\u062c\u0650 \u0625\u0644\u0649 \u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0650 \u0628\u0635\u0648\u0631\u0629 \u0646\u0648\u0639\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u0623\u0636\u062f\u0627\u062f IgE \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629\u064f \u0628\u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u0650 \u0639\u0627\u0644\u064a\u0629\u0650 \u0627\u0644\u0625\u0644\u0641\u0629\u0650 \u0639\u0644\u0649 \u0633\u0637\u0648\u062d\u0650 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u062d\u0633\u0651\u0633\u0629\u0650 Sensitized Cells (\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u062f\u064a\u0646\u0629 \u0648\u0627\u0644\u0623\u064e\u0633\u064f\u0633\u0627\u062a) \u0648\u062d\u062f\u0648\u062b \u062a\u0641\u0639\u064a\u0644\u064d \u062a\u0635\u0627\u0644\u0628\u064a\u0651\u064d cross-linking activation \u0644\u0647\u0630\u0647\u0650 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u0650\u060c \u0648\u0645\u0646\u0652 \u062b\u064e\u0645\u0651\u064e \u062a\u064e\u0641\u0639\u064a\u0644\u064f \u0627\u0644\u0639\u062f\u064a\u062f\u0650 \u0645\u0646\u0652 \u0633\u0628\u0644\u0650 \u0646\u0642\u0644\u0650 \u0627\u0644\u0634\u0651\u0627\u0631\u0629\u0650 \u0627\u0644\u062e\u0644\u0648\u064a\u0651\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0646\u062a\u0647\u064a \u0628\u0625\u0641\u0631\u0627\u063a\u064d \u0633\u0631\u064a\u0639\u064d \u0644\u0645\u0643\u0648\u0646\u0627\u062a\u0650 \u0627\u0644\u062d\u0628\u064a\u0628\u0627\u062a\u0650 degranulation \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629\u0650 \u0636\u0645\u0646\u064e \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u062a\u064a \u062a\u0634\u0645\u064e\u0644\u064f \u0627\u0644\u0639\u062f\u064a\u062f\u064e \u0645\u0646\u064e \u0627\u0644\u0648\u0633\u0627\u0626\u0637\u0650 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651\u0629\u0650 \u0627\u0644\u0645\u0635\u0646\u0651\u0639\u0629\u0650 \u0645\u064f\u0633\u0628\u0642\u0627\u064b \u0645\u062b\u0644\u064e \u0627\u0644\u0647\u064a\u0633\u062a\u0627\u0645\u064a\u0646\u0652 histamine\u060c \u0648\u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u063a\u0644\u0627\u0646\u062f\u064a\u0646\u0627\u062a\u0652 prostaglandins\u060c \u0648\u0627\u0644\u0644\u064a\u0643\u0648\u062a\u0631\u064a\u0646\u0627\u062a leukotrienes <sup>6<\/sup>.<\/p>\n<p>\u064a\u0628\u0631\u0632 \u0627\u0644\u0625\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646-13 \u0628\u0627\u0644\u062a\u0636\u0627\u0641\u0631 \u0645\u0639 \u0627\u0644\u0625\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646-4 \u0639\u0627\u0645\u0644\u0627\u064b \u0645\u062d\u0648\u0631\u064a\u0627\u064b \u0641\u064a \u062a\u0637\u0648\u0631 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062b\u0627\u0646\u064a. \u0627\u0644\u0625\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646-13 \u0628\u0631\u0648\u062a\u064a\u0646 \u0633\u0643\u0631\u064a \u0628\u0648\u0632\u0646 \u062c\u0632\u064a\u0626\u064a \u064a\u0642\u0627\u0631\u0628 12 \u0643\u064a\u0644\u0648 \u062f\u0627\u0644\u062a\u0648\u0646\u060c \u064a\u062a\u0634\u0627\u0628\u0647 \u0648\u0638\u064a\u0641\u064a\u0627\u064b \u0645\u0639 \u0627\u0644\u0625\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646-4 \u0648\u062a\u062a\u0648\u0636\u0639 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u0645\u0632\u0629 \u0644\u0643\u0644\u064a\u0647\u0645\u0627 \u0628\u0634\u0643\u0644 \u0645\u062a\u062c\u0627\u0648\u0631 \u0641\u064a \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u0637\u0648\u064a\u0644 \u0644\u0644\u0635\u0628\u063a\u064a \u0627\u0644\u062e\u0627\u0645\u0633 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u0635\u0628\u064a\u063a\u064a 5q23.31 \u0648\u0630\u0644\u0643 \u0636\u0645\u0646 \u062a\u0639\u0646\u0642\u062f \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u0645\u0632\u0629 \u0644\u0639\u0648\u0627\u0645\u0644 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062b\u0627\u0646\u064a Th2\u060c \u0648\u0645\u0646\u0647\u0627 \u0643\u0644 \u0645\u0646 IL-4 \u0648IL-3 \u0648IL-5 \u0648IL-9 \u0648\u062c\u064a\u0646 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u062d\u0641\u0651\u0632 \u0644\u0646\u0645\u0648 \u0627\u0644\u0645\u062d\u0628\u0651\u0628\u0627\u062a \u0648\u0627\u0644\u0628\u0627\u0644\u0639\u0627\u062a granulocytes macrophages colony stimulating factor \u00a0(GM-CSF)<sup>7<\/sup>.<\/p>\n<p>\u064a\u0624\u062f\u0651\u064a IL-13 \u0623\u062f\u0648\u0627\u0631\u0647\u064f \u0641\u064a \u062a\u0637\u0648\u0651\u0631\u0650 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629\u0650 \u0627\u0644\u0623\u0631\u062c\u064a\u0651\u0629\u0650 \u0648\u0627\u0644\u0645\u062a\u0645\u062b\u0651\u0644\u064e\u0629\u0650 \u0641\u064a \u062a\u062d\u0641\u064a\u0632\u0650 \u062a\u0643\u0627\u062b\u0631\u0650 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0651\u0629\u0650 \u0648\u062a\u062d\u0631\u064a\u0636\u0650 \u0627\u0646\u0642\u0644\u0627\u0628\u0650 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0625\u0633\u0648\u064a\u0651 \u0644\u0644\u0623\u0636\u062f\u0627\u062f \u0625\u0644\u0649 IgE (IgE isotype class switching)\u060c \u0648\u062a\u0641\u0639\u064a\u0644 \u0627\u0644\u062d\u0645\u0636\u0627\u062a\u0650 \u0648\u0627\u0644\u0623\u0633\u0633\u0627\u062a\u0650 \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u062f\u064a\u0646\u0629\u0650\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629\u0650 \u0625\u0644\u0649 \u062a\u062d\u0641\u064a\u0632\u0650 \u0625\u0646\u062a\u0627\u062c\u0650 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\u0625\u0644\u0649 \u0625\u0639\u0627\u062f\u0629\u0650 \u0642\u0648\u0644\u0628\u0629\u0650 remodeling \u0627\u0644\u0637\u0631\u0642 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 <sup>8<\/sup>.<\/p>\n<p>\u062a\u0624\u062f\u064a \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0628\u064a\u0626\u064a\u0629 \u062f\u0648\u0631\u0627\u064b \u0647\u0627\u0645\u0627\u064b \u0641\u064a \u062a\u0637\u0648\u0631 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u062a\u0631\u0643\u064a\u0628\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u0644\u0623\u0641\u0631\u0627\u062f \u062a\u0634\u0643\u0651\u0644 \u0639\u0627\u0645\u0644\u0627\u064b \u062d\u0627\u0633\u0645\u0627\u064b \u0641\u064a \u0627\u0644\u0623\u0647\u0628\u0629 \u0644\u062a\u0637\u0648\u064a\u0631 \u0631\u062f\u0648\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u062a\u0623\u062a\u0628\u064a\u0629 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\u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a +2044A&gt;G \u0648\u0627\u0644\u0623\u0647\u0628\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0639\u0646\u062f \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u064a\u0646.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Materials and methods<\/strong><\/p>\n<p>\u0642\u0645\u0646\u0627 \u0628\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u062a\u0643\u0648\u0646 \u062f\u0631\u0627\u0633\u0629 \u0631\u0635\u062f\u064a\u0629 \u0645\u0646 \u0646\u0645\u0637 \u062d\u0627\u0644\u0629-\u0634\u0627\u0647\u062f Observational Case-Control study\u060c \u062d\u064a\u062b \u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 64 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0634\u062e\u0635\u0627\u064b \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0623\u0646\u0641 \u0627\u0644\u062a\u062d\u0633\u0633\u064a \u0623\u0648 \u0627\u0644\u0631\u0628\u0648 \u0627\u0644\u0623\u0631\u062c\u064a \u0627\u0644\u0645\u0624\u0643\u062f \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0648\u062e\u0632 \u0628\u0627\u0644\u062c\u0644\u062f Skin Prick Test (SPT)\u060c \u0645\u0646 \u0643\u0644\u0627 \u0627\u0644\u062c\u0646\u0633\u064a\u0646 \u0648\u0645\u0645\u0646 \u062a\u0632\u064a\u062f \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0639\u0646 \u062e\u0645\u0633 \u0633\u0646\u0648\u0627\u062a\u060c \u0641\u064a \u062d\u064a\u0646\u00a0 \u0634\u0645\u0644\u062a \u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0627\u0647\u062f Control 35 \u0641\u0631\u062f\u0627\u064b \u0633\u0644\u064a\u0645\u0627\u064b \u0638\u0627\u0647\u0631\u064a\u0627\u064b \u0648\u0646\u0641\u064a\u062a \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0623\u062d\u062f \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0633\u0644\u0628\u064a\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0648\u062e\u0632 \u0628\u0627\u0644\u062c\u0644\u062f SPT \u0644\u0644\u0645\u0633\u062a\u0623\u0631\u062c\u0627\u062a \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629\u060c \u0627\u0633\u062a\u0628\u064f\u0639\u0650\u062f\u064e \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u063a\u064a\u0631 \u0627\u0644\u0642\u0627\u062f\u0631\u064a\u0646 \u0639\u0644\u0649 \u0641\u0647\u0645 \u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u0623\u0633\u0628\u0627\u0628 \u0645\u0639\u0631\u0641\u064a\u0629 \u0623\u0648 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SPT.<\/p>\n<p>\u062d\u0635\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u0631\u0642\u0645 (5675) \u062a\u0627\u0631\u064a\u062e (24\/10\/2023)\u060c \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0623\u0641\u0631\u0627\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0633\u062a\u0646\u064a\u0631\u0629 \u0642\u0628\u0644 \u0627\u0646\u062e\u0631\u0627\u0637\u0647\u0645 \u0641\u064a\u0647\u0627\u060c\u0648\u0630\u0644\u0643 \u0628\u0639\u062f \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0634\u0631\u0648\u062d\u0627\u062a \u0627\u0644\u0648\u0627\u0641\u064a\u0629 \u0639\u0646 \u0647\u062f\u0641 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0627\u0644\u0645\u0631\u062c\u0648\u0629 \u0645\u0646\u0647\u0627 \u0648\u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629.<\/p>\n<p>\u0623\u062c\u0631\u064a \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0648\u062e\u0632 \u0628\u0627\u0644\u062c\u0644\u062f \u062a\u062d\u062a \u0625\u0634\u0631\u0627\u0641 \u0637\u0628\u064a\u060c \u0648\u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0639\u062a\u064a\u062f\u0629 \u0645\u0646 \u0634\u0631\u0643\u0629 Immunotek \u0627\u0644\u0625\u0633\u0628\u0627\u0646\u064a\u0629\u060c \u062d\u064a\u062b \u062a\u0645\u0651 \u0648\u0636\u0639 \u0642\u0637\u0631\u0627\u062a \u0645\u0646 \u0645\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0645\u0633\u062a\u0623\u0631\u062c\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0627\u0644\u0645\u064f\u0636\u0645\u0651\u0646\u0629 \u0641\u064a \u0627\u0644\u0639\u062a\u064a\u062f\u0629 (\u0627\u062b\u0646\u0627\u0646 \u0648\u0639\u0634\u0631\u0648\u0646 \u0645\u062d\u0644\u0648\u0644\u0627\u064b \u0623\u0628\u0631\u0632\u0647\u0627 \u0627\u0644\u0639\u062b \u0627\u0644\u0645\u0646\u0632\u0644\u064a \u0627\u0644\u0628\u062d\u0631\u064a \u0648\u0627\u0644\u0637\u062d\u064a\u0646\u064a \u0648\u0648\u0628\u0631 \u0627\u0644\u0643\u0644\u0627\u0628 \u0648\u0627\u0644\u0642\u0637\u0637\u060c \u0648\u0645\u0646 \u062b\u0645 \u0648\u062e\u0632 \u0623\u0645\u0627\u0643\u0646 \u0627\u0644\u0642\u0637\u0631\u0627\u062a \u0628\u0648\u0627\u062e\u0632\u0627\u062a \u0639\u0642\u064a\u0645\u0629 \u0645\u062e\u0635\u0635\u0651\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u060c \u0648\u0645\u0631\u0627\u0642\u0628\u0629 \u0638\u0647\u0648\u0631 \u0623\u0639\u0631\u0627\u0636 \u0631\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0645\u062f\u0629 \u0628\u064a\u0646 15-20 \u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u0644\u0630\u064a \u064a\u062a\u062c\u0644\u0651\u0649 \u0628\u0638\u0647\u0648\u0631 \u062d\u0637\u0627\u0637\u0629 \u0648\u0627\u062d\u0645\u0631\u0627\u0631 \u0641\u064a \u0645\u0643\u0627\u0646 \u0627\u0644\u0648\u062e\u0632\u060c \u0648\u0627\u0639\u062a\u0645\u062f\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u0625\u062e\u062a\u0628\u0627\u0631 \u0628\u062d\u0637\u0627\u0637\u0629 \u0642\u0637\u0631\u0647\u0627 \u0623\u0639\u0644\u0649 \u0623\u0648 \u0645\u0633\u0627\u0648\u064a\u064d \u0644\u062b\u0644\u0627\u062b\u0629 \u0645\u0644\u0644\u064a\u0645\u064a\u062a\u0631\u0627\u062a\u060c \u0648\u0636\u0644\u0643 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0634\u0627\u0647\u062f\u064a\u0646 \u0623\u062d\u062f\u0647\u0645\u0627 \u0625\u064a\u062c\u0627\u0628\u064a (\u0627\u0644\u0647\u064a\u0633\u062a\u0627\u0645\u064a\u0646) \u0648\u0627\u0644\u0622\u062e\u0631 \u0633\u0644\u0628\u064a \u0648\u0647\u0648 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u062d\u0627\u0645\u0644 \u0644\u0644\u0645\u0633\u062a\u0623\u0631\u062c\u0627\u062a.<\/p>\n<p>\u062c\u064f\u0645\u0639\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0639\u064a\u0627\u062f\u0627\u062a \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0641\u064a \u062f\u0645\u0634\u0642 \u0648\u0639\u064a\u0627\u062f\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0629 \u063a\u0632\u0644 \u062f\u064a\u0628 \u0641\u064a \u0627\u0644\u0644\u0627\u0630\u0642\u064a\u0629\u060c \u062d\u064a\u062b \u0628\u064f\u0632\u0650\u0644\u064e 3 \u0645\u0644 \u0645\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0639\u0644\u0649 \u0623\u0646\u0627\u0628\u064a\u0628 \u062a\u062d\u0648\u064a \u0645\u0627\u0646\u0639 \u0627\u0644\u062a\u062e\u062b\u0631 \u0625\u064a\u062a\u064a\u0644\u064a\u0646 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0623\u0645\u064a\u0646 \u0631\u0628\u0627\u0639\u064a \u062d\u0645\u0636 \u0627\u0644\u062e\u0644 Ethylenediaminetetraacetic acid EDTA\u060c \u062a\u0644\u0627\u0647 \u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u062e\u0644\u0627\u0644 \u0645\u062f\u0629 \u0623\u0642\u0635\u0627\u0647\u0627 \u064a\u0648\u0645\u064a\u0646 \u0645\u0646 \u062a\u0627\u0631\u064a\u062e \u0627\u0644\u0633\u062d\u0628 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u062a\u064a\u062f\u0629 \u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0645\u0646 \u0634\u0631\u0643\u0629 VIVANTIS \u0627\u0644\u0645\u0627\u0644\u064a\u0632\u064a\u0629\u060c \u0648\u062a\u0645 \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0646\u0642\u0627\u0648\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0648\u0642\u064a\u0627\u0633 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0645\u0633\u062a\u062e\u0644\u0635 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 Nanodrop\u060c \u062d\u064a\u062b \u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 49.16 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0643\u0644\u060c \u0641\u064a \u062d\u064a\u0646 \u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0646\u0642\u0627\u0648\u0629 1.6.<\/p>\n<p>\u0627\u0644\u062a\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a<\/p>\n<p>\u0623\u062c\u0631\u064a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u0631\u0627\u0632 \u0627\u0644\u062a\u0633\u0644\u0633\u0644\u064a Polymerase Chain Reaction (PCR) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0632\u0648\u062c \u0627\u0644\u0645\u0634\u0627\u0631\u0639 \u0627\u0644\u0645\u0642\u062a\u0628\u0633 \u0645\u0646 \u0627\u0644\u0623\u062f\u0628\u064a\u0627\u062a <sup>10<\/sup>\u060c \u0648\u0627\u0644\u0630\u064a \u062a\u0645 \u062a\u0635\u0645\u064a\u0645\u0647 \u0644\u062a\u0636\u062e\u064a\u0645 \u0634\u062f\u0641\u0629 \u0628\u0637\u0648\u0644 236 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 \u0648\u062e\u0644\u0642 \u0645\u0648\u0642\u0639 \u062a\u0642\u064a\u064a\u062f \u0644\u0644\u0623\u0646\u0632\u064a\u0645 NlaIV \u0639\u0646\u062f \u0627\u0644\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062d\u0627\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a +2044A&gt;G\u060c \u0648\u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (1) \u00a0\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u0645\u0634\u0627\u0631\u0639 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0648\u062e\u0635\u0627\u0626\u0635\u0647\u0627.<\/p>\n<p>\u0623\u064f\u062e\u0650\u0630\u064e 3 \u0645\u0643\u0631\u0648\u0644\u062a\u0631 \u0645\u0646 \u0645\u0646\u062a\u062c \u0627\u0644\u0640 PCR \u0648\u0623\u0636\u064a\u0641 \u0644\u0647 1 \u0645\u0643\u0631\u0648\u0644\u062a\u0631 \u0645\u0646 \u0643\u0644 \u0645\u064e\u0634\u0631\u064e\u0639\u00a0 \u0628\u062a\u0631\u0643\u064a\u0632 10 \u0628\u064a\u0643\u0648\u0645\u0648\u0644\/\u0645\u0643\u0631\u0648\u0644\u062a\u0631 \u0648 5 \u0645\u0643\u0631\u0648\u0644\u062a\u0631 \u0645\u0646 \u0645\u0632\u064a\u062c \u0644\u062a\u0641\u0627\u0639\u0644 PCR (5x Master Mix) \u0645\u0646 \u0634\u0631\u0643\u0629 Everogen\u00ae \u0627\u0644\u0631\u0648\u0633\u064a\u0651\u0629\u060c \u0648\u0627\u062a\u0628\u0639 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (2). \u0648\u062a\u0645 \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0646\u062c\u0627\u062d \u0627\u0644\u062a\u0636\u062e\u064a\u0645 \u0628\u062a\u0631\u062d\u064a\u0644 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0645\u0646 \u0627\u0644\u0623\u063a\u0627\u0631\u0648\u0632 \u0628\u062a\u0631\u0643\u064a\u0632 2%.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2038 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4-300x173.png\" alt=\"\" width=\"571\" height=\"329\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4-300x173.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4-768x444.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4.png 897w\" sizes=\"auto, (max-width: 571px) 100vw, 571px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u0646\u0651\u064f\u0645\u0650\u0637\u064e\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0627\u062a\u0628\u0627\u0639 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0644\u0623\u0637\u0648\u0627\u0644 \u0634\u062f\u0641 \u0627\u0644\u062a\u0642\u064a\u064a\u062f Restriction Fragment Length Polymorphism (RFLP) \u062d\u064a\u062b \u0642\u064f\u0637\u0650\u0639\u064e\u062a \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0640 PCR \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0646\u0632\u064a\u0645 NlaIV (\u0648\u062d\u062f\u0629 \u062f\u0648\u0644\u064a\u0629\/\u0645\u0643\u0631\u0648\u063a\u0631\u0627\u0645)\u060c \u062a\u0645 \u062a\u0631\u062d\u064a\u0644 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0647\u0636\u0645 \u0627\u0644\u0623\u0646\u0632\u064a\u0645\u064a \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0645\u0646 \u0627\u0644\u0623\u063a\u0627\u0631\u0648\u0632 \u0628\u062a\u0631\u0643\u064a\u06324%\u060c \u0648\u0638\u064f\u0647\u0651\u0650\u0631\u064e\u062a \u0627\u0644\u0639\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0625\u0638\u0647\u0627\u0631 \u0648\u062a\u0648\u062b\u064a\u0642 \u0627\u0644\u0647\u0644\u0627\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 \u0645\u0646 \u0634\u0631\u0643\u0629 Cleaver Scientific \u0627\u0644\u0628\u0631\u064a\u0637\u0627\u0646\u064a\u0629.<\/p>\n<p>\u0623\u062c\u0631\u064a \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u063a\u0629 \u0627\u0644\u0628\u0631\u0645\u062c\u0629 R \u0648\u0628\u0631\u0646\u0627\u0645\u062c GraphPad Prism (version 8.0.1)\u060c \u0642\u064f\u0648\u0631\u0650\u0646\u064e \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0651 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 Chi-square \u0644\u0645\u0639\u0631\u0641\u0629 \u0641\u064a\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u064a\u064f\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P-value&lt; 0.05)\u060c \u0623\u0648 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0627\u0644\u0645\u0635\u0627\u062f\u0641\u0629 (P-value&gt; 0.05).<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong><strong>Results<\/strong><\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u062a\u0633\u0644\u0633\u0644\u064a <\/strong><strong>PCR<\/strong><strong> \u0648\u0627\u0644\u0642\u0637\u0639 \u0627\u0644\u0623\u0646\u0632\u064a\u0645\u064a:<\/strong><\/p>\n<p>\u064a\u0646\u062a\u062c \u0639\u0646 \u062a\u0641\u0627\u0639\u0644 PCR \u0634\u062f\u0641\u0629 \u0645\u0646 DNA \u0628\u0637\u0648\u0644 \u062a\u0642\u0631\u064a\u0628\u064a 236 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 \u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0643\u0645\u0627 \u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u0634\u0643\u0644 (1).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2039 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/5-277x300.png\" alt=\"\" width=\"315\" height=\"341\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/5-277x300.png 277w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/5.png 412w\" sizes=\"auto, (max-width: 315px) 100vw, 315px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u0643\u0627\u0646\u062a \u0646\u0648\u0627\u062a\u062c RFLP \u0645\u062a\u0637\u0627\u0628\u0642\u0629 \u0645\u0639 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0629 \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629\u060c \u062d\u064a\u062b \u064a\u062a\u0639\u0631\u0641 \u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u062a\u0642\u064a\u064a\u062f NlaIV \u0639\u0644\u0649 \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062f\u0646\u0627 GGNNCC \u0648\u0627\u0644\u0630\u064a \u064a\u062a\u0643\u0631\u0631 \u0645\u0631\u062a\u064a\u0646 \u0636\u0645\u0646 \u0627\u0644\u0634\u062f\u0641\u0629 \u0627\u0644\u0645\u0636\u062e\u0645\u0629\u061b \u0627\u0644\u0623\u0648\u0644\u0649 \u0628\u0639\u062f 16 \u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u064b \u0645\u0646 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 5<sup>\u2019<\/sup> \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0642\u0628\u0644 32 \u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u064b \u0645\u0646 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 3<sup>\u2019<\/sup>\u00a0 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u062d\u0627\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u060c \u064a\u0639\u0645\u0644 \u0627\u0644\u0645\u0648\u0642\u0639 \u0642\u0631\u0628 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 5<sup>\u2019<\/sup> \u0634\u0627\u0647\u062f\u0627\u064b \u062f\u0627\u062e\u0644\u064a\u0627\u064b \u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u0623\u0646\u0632\u064a\u0645 \u0639\u0644\u0649 \u0627\u0644\u0642\u0637\u0639 \u0628\u0635\u0648\u0631\u0629 \u0645\u0633\u062a\u0642\u0644\u0629 \u0639\u0646 \u0648\u062c\u0648\u062f \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0623\u0648 \u063a\u064a\u0627\u0628\u0647\u060c \u0641\u064a \u062d\u064a\u0646 \u064a\u0643\u0648\u0646 \u0627\u0644\u0642\u0637\u0639 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 \u0642\u0631\u0628 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 3<sup>\u2019<\/sup> \u0645\u0624\u0634\u0631\u0627\u064b \u0644\u0627\u0645\u062a\u0644\u0627\u0643 \u0627\u0644\u0641\u0631\u062f \u0644\u0644\u0623\u0644\u064a\u0644 G \u0645\u0646 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0633\u0643\u0644\u064a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u060c \u0648\u0628\u0627\u0644\u0646\u0638\u0631 \u0625\u0644\u0649 \u0627\u0644\u0634\u0643\u0644 (2) \u0627\u0644\u0630\u064a \u064a\u0645\u062b\u0644 \u062a\u0631\u062d\u064a\u0644 \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0640 PCR \u0628\u0639\u062f \u062a\u0637\u0628\u064a\u0642 \u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644 \u0627\u0644\u0642\u0637\u0639 \u0646\u0644\u0627\u062d\u0638 \u0638\u0647\u0648\u0631 \u0634\u062f\u0641\u0629 \u0628\u0637\u0648\u0644 210 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 \u0641\u064a \u062d\u0627\u0644 \u0643\u0627\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0644\u0641\u0631\u062f \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0644\u0644\u0623\u0644\u064a\u0644 A (AA)\u060c \u0648\u0634\u062f\u0641\u0629 \u0628\u0637\u0648\u0644 178 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 \u0641\u064a \u062d\u0627\u0644 \u0643\u0627\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0647\u0648 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0645\u062a\u063a\u0627\u064a\u0631(GG)\u060c \u0648\u0641\u064a \u062d\u0627\u0644 \u0643\u0627\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u0632\u064a\u062c\u0648\u062a (AG) \u064a\u064f\u0644\u0627\u062d\u0638 \u0638\u0647\u0648\u0631 \u0643\u0644\u062a\u0627 \u0627\u0644\u0634\u062f\u0641\u062a\u064a\u0646.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2040 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/6-300x220.png\" alt=\"\" width=\"353\" height=\"259\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/6-300x220.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/6.png 472w\" sizes=\"auto, (max-width: 353px) 100vw, 353px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u062a\u0648\u0627\u062a\u0631\u0627\u062a \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0648\u0627\u0644\u0627\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f:<\/strong><\/p>\n<p>\u0628\u064a\u0651\u0646\u062a \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a AA \u0643\u0627\u0646 \u0623\u0639\u0644\u0649 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0628\u0646\u0633\u0628\u0629 54.3% \u0645\u0642\u0627\u0628\u0644 6.2%\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628. \u0641\u064a \u062d\u064a\u0646 \u0643\u0627\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a GG \u0627\u0644\u0623\u0639\u0644\u0649 \u062a\u0648\u0627\u062a\u0631\u0627\u064b \u0644\u062f\u0649 \u0627\u0644\u062d\u0627\u0644\u0627\u062a (64.1%) \u0645\u0642\u0627\u0628\u0644 (28.6%) \u0639\u0646\u062f \u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c \u0623\u0645\u0627 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u0632\u064a\u062c\u0648\u062a AG \u0641\u0642\u062f \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u062a\u0648\u0627\u062a\u0631\u0647 \u0644\u062f\u0649 \u0627\u0644\u062d\u0627\u0644\u0627\u062a 29.7% \u0645\u0642\u0627\u0628\u0644 17.1% \u0644\u062f\u0649 \u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c \u0648\u0628\u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0645\u0631\u0628\u0639\u060c \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 P \u0645\u0639\u062a\u0651\u062f\u0627\u064b \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u0642\u0648\u0651\u0629 (p&lt;0.0001). \u0648\u064a\u0648\u0636\u062d \u0627\u0644\u0634\u0643\u0644 )3 (\u0645\u0642\u0627\u0631\u0646\u0629 \u0644\u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u064a\u0646 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0634\u0648\u0627\u0647\u062f.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2041 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/7-300x280.png\" alt=\"\" width=\"331\" height=\"309\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/7-300x280.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/7.png 430w\" sizes=\"auto, (max-width: 331px) 100vw, 331px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u0643\u0645\u0627 \u062a\u0645\u062a \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0628\u0627\u062a\u0628\u0627\u0639 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u0645\u0631\u0628\u0639 \u062d\u064a\u062b \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 G \u0646\u0633\u0628\u0629 \u0642\u062f\u0631\u0647\u0627 78.9% \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0645\u0642\u0627\u0628\u0644 \u0646\u0633\u0628\u0629 \u0644\u0645 \u062a\u062a\u062c\u0627\u0648\u0632 37.1% \u0644\u062f\u0649 \u063a\u064a\u0631 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 (\u0627\u0644\u0634\u0648\u0627\u0647\u062f)\u060c \u0648\u0644\u062f\u0649 \u062d\u0633\u0627\u0628 \u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0631\u062c\u062d\u064a\u0629 Odds Ratio (OR)\u060c \u0628\u064a\u0651\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0628\u0623\u0646 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0630\u064a\u0646 \u064a\u062d\u0645\u0644\u0648\u0646 \u0627\u0644\u0623\u0644\u064a\u0644 G \u0644\u062f\u064a\u0647\u0645 \u0645\u0639\u062f\u0644 \u0623\u0631\u062c\u062d\u064a\u0629 \u0623\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0640\u0646\u062d\u0648 \u0633\u062a\u0629 \u0623\u0636\u0639\u0627\u0641 \u0645\u0646 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u062d\u0627\u0645\u0644\u064a\u0646 \u0644\u0644\u0623\u0644\u064a\u0644 A (OR=6.3, 95% CI (3.24-11.81))\u060c \u0648\u0628\u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u0627\u062a\u0628\u0627\u0639 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0633\u0627\u0626\u062f \u062a\u0628\u064a\u0646 \u0623\u0646 \u0627\u0645\u062a\u0644\u0627\u0643 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0646\u0633\u062e\u0629 \u0648\u0627\u062d\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0645\u0646 \u0627\u0644\u0623\u0644\u064a\u0644 G (\u0627\u0644\u0646\u0645\u0637\u064a\u0646 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 AG \u0648GG) \u064a\u0632\u064a\u062f \u0645\u0646 \u0645\u0639\u062f\u0644 \u0623\u0631\u062c\u062d\u064a\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0646\u062d\u0648 \u0633\u0628\u0639\u0629 \u0639\u0634\u0631 \u0636\u0650\u0639\u0641\u0627\u064b \u0639\u0646 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u064a\u062d\u0645\u0644\u0648\u0646 \u0646\u0633\u062e\u062a\u064a\u0646 \u0645\u0646 \u0627\u0644\u0623\u0644\u064a\u0644 A (OR=17.81, 95% CI (5.196 -51.8))\u060c \u0623\u0645\u0627 \u0627\u0645\u062a\u0644\u0627\u0643 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0644\u0646\u0633\u062e\u062a\u064a\u0646 \u0645\u0646 \u0627\u0644\u0623\u0644\u064a\u0644 G (\u0627\u0644\u0646\u0645\u0637 GG) \u064a\u0632\u064a\u062f \u0645\u0639\u062f\u0644 \u0623\u0631\u062c\u062d\u064a\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0646\u062d\u0648 \u0623\u0631\u0628\u0639\u0629 \u0623\u0636\u0639\u0627\u0641 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0644\u064a\u0644 (\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a AA) \u0623\u0648 \u0627\u0645\u062a\u0644\u0627\u0643 \u0646\u0633\u062e\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646\u0647 (\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a AG) (OR=4.457, 95% CI (1.867-11.39))\u060c \u0648\u0642\u062f \u0643\u0627\u0646\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u062a\u0628\u0639\u0651\u0629 \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639\u062a\u0651\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (<em>P&lt;0.001<\/em>) \u0648\u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (3) \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u0627\u062a\u0628\u0627\u0639 \u0627\u0644\u0646\u0645\u0648\u0630\u062c\u064a\u0646 \u0627\u0644\u0633\u0627\u0626\u062f \u0648\u0627\u0644\u0645\u062a\u0646\u062d\u064a \u0648\u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2042 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/8-300x189.png\" alt=\"\" width=\"494\" height=\"311\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/8-300x189.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/8-768x483.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/8.png 862w\" sizes=\"auto, (max-width: 494px) 100vw, 494px\" \/><\/p>\n<p><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Discussion<\/strong><\/p>\n<p>\u0628\u064a\u0646\u0651\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0648\u062c\u0648\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0642\u0648\u064a\u0651\u0629 \u0628\u064a\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 +2044A&gt;G \u0648\u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629\u060c \u062d\u064a\u062b \u062a\u0628\u064a\u0646 \u0623\u0646 \u0627\u0645\u062a\u0644\u0627\u0643 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0644\u0644\u0623\u0644\u064a\u0644 G (\u0623\u0644\u064a\u0644 \u0627\u0644\u062e\u0637\u0648\u0631\u0629) \u064a\u0632\u064a\u062f \u0645\u0646 \u0623\u0631\u062c\u062d\u064a\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0648\u0641\u0642 \u0627\u0644\u0646\u0645\u0648\u0630\u062c\u064a\u0646 \u0627\u0644\u0633\u0627\u0626\u062f \u0648\u0627\u0644\u0645\u062a\u0646\u062d\u064a \u0641\u064a \u062d\u064a\u0646 \u064a\u0645\u0644\u0643 \u0627\u0644\u0623\u0644\u064a\u0644 A \u062f\u0648\u0631\u0627\u064b \u0648\u0642\u0627\u0626\u064a\u0627\u064b \u0645\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629\u060c \u0648\u0642\u062f \u0627\u062a\u0641\u0642\u0646\u0627 \u0641\u064a \u0630\u0644\u0643 \u0645\u0639 \u0623\u0646\u0648\u0627\u0631 \u0648\u0632\u0645\u0644\u0627\u0626\u0647\u0627<sup>11<\/sup> \u0641\u064a \u0627\u0644\u0639\u0631\u0627\u0642 \u0627\u0644\u0630\u064a\u0646 \u0648\u062c\u062f\u0648\u0627 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a GG \u0648\u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0631\u0628\u0648 \u0625\u0644\u0627 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0644\u0645 \u064a\u0643\u0646 \u0645\u0639\u062a\u062f\u0651\u0627\u064b \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0647\u0645\u060c \u0648\u0627\u062e\u062a\u0644\u0641\u0646\u0627 \u0645\u0639 \u0643\u0644 \u0645\u0646 Begh\u00e9 \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0641\u064a \u0625\u064a\u0637\u0627\u0644\u064a\u0627 \u0648Baye \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0641\u064a \u0623\u0645\u0631\u064a\u0643\u0627 \u0648Xi \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0641\u064a \u0627\u0644\u0635\u064a\u0646 <sup>12\u201314<\/sup><\/p>\n<p>\u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0639\u0632\u0649 \u0647\u0630\u0647 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0625\u0644\u0649 \u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0625\u062b\u0646\u064a\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629\u060c \u0648\u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0628\u064a\u0626\u064a\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0624\u062f\u0651\u064a \u062f\u0648\u0631\u0627\u064b \u0643\u0628\u064a\u0631\u0627\u064b \u0641\u064a \u0627\u0644\u0623\u0647\u0628\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0631\u0628\u0648 \u0628\u0627\u0644\u062a\u0636\u0627\u0641\u0631 \u0645\u0639 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629\u060c \u0648 \u0627\u0644\u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u062a\u063a\u0627\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u0636 Heterogenous \u0648\u0627\u0644\u062a\u0639\u0642\u064a\u062f \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u062a\u0639\u062f\u062f \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0624\u0647\u0628\u0629 \u0645\u0646 \u0639\u0648\u0627\u0645\u0644 \u0628\u064a\u0626\u064a\u0629 \u0648\u0639\u0648\u0627\u0645\u0644 \u062c\u064a\u0646\u064a\u0629\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u062e\u062a\u0644\u0627\u0641 \u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u0643\u0634\u0641 \u0639\u0646 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0628\u064a\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0648\u0627\u0644\u062a\u064a \u062a\u0643\u0648\u0646 \u062f\u0642\u062a\u0651\u0647\u0627 \u0639\u0627\u0645\u0644\u0627\u064e \u0645\u0647\u0645\u0627\u064b \u0641\u064a \u062a\u062c\u0646\u0628 \u0627\u0644\u0627\u0646\u062d\u064a\u0627\u0632.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/p>\n<p>\u062a\u0639\u062f \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u0623\u0648\u0644\u0649 \u0641\u064a \u0633\u0648\u0631\u064a\u0629 \u0641\u064a \u062a\u062d\u0631\u0651\u064a \u0641\u0631\u0636\u064a\u0629 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 <em>+2044A&gt;G<\/em> \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0651\u0629 (\u0627\u0644\u0631\u0628\u0648 \u0627\u0644\u0623\u0631\u062c\u064a \u0648\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0623\u0646\u0641 \u0627\u0644\u0623\u0631\u062c\u064a)\u060c \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0623\u0644\u064a\u0644 G \u0644\u0644\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 <em>+2044A&gt;G<\/em> \u0628\u0632\u064a\u0627\u062f\u0629 \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0623\u0631\u062c\u062d\u064a\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0651\u0629 \u0639\u0646\u062f \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0633\u0648\u0631\u064a\u064a\u0646.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a <\/strong><strong>List of abbreviations<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"312\">Arginine<\/td>\n<td width=\"312\">Arg<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Antigen Presenting Cells<\/td>\n<td width=\"312\">APCs<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Global Asthma Network<\/td>\n<td width=\"312\">GAN<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Granulocytes Macrophages Colony Stimulating Factor<\/td>\n<td width=\"312\">GM-CSF<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Genome Wide Association Studies<\/td>\n<td width=\"312\">GWAS<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Immunoglobulin E<\/td>\n<td width=\"312\">IgE<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Interlukin-13<\/td>\n<td width=\"312\">IL-13<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Odds Ratio<\/td>\n<td width=\"312\">OR<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Polymerase chain reaction<\/td>\n<td width=\"312\">PCR<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Restriction fragment length polymorphism<\/td>\n<td width=\"312\">RFLP<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Single Nucleotide Polymorphisms<\/td>\n<td width=\"312\">SNPs<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Skin Prick Test<\/td>\n<td width=\"312\">SPT<\/td>\n<\/tr>\n<tr>\n<td width=\"312\">Vascular Cell Adhesion Molecule-1<\/td>\n<td width=\"312\">VCAM-1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 <\/strong><strong>Ethics approval and consent to participate<\/strong><\/p>\n<p>\u062d\u0635\u0644\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a\u0651 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 24\/10\/2023\u060c \u0648\u0628\u0631\u0642\u0645 5675.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong><strong>Conflict of interests<\/strong><\/p>\n<p><strong>\u00a0<\/strong>\u064a\u0642\u0631 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong><strong>Funding<\/strong><\/p>\n<p>\u062a\u0645 \u062a\u0645\u0648\u064a\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u0642\u0650\u0628\u064e\u0644 \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong><strong>\u00a0contributions<\/strong><strong>\u2019<\/strong><strong>Authors<\/strong><\/p>\n<p>\u0639\u0628\u062f\u0627\u0644\u0644\u0647 \u0628\u0644\u0648\u0644: \u0627\u0644\u0628\u0627\u062d\u062b \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u060c \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0639\u0645\u0644\u064a \u0645\u0646 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0646\u0638\u0631\u064a\u0629 \u0644\u0644\u0623\u0637\u0631\u0648\u062d\u0629 \u0648\u0627\u0644\u0645\u0642\u0627\u0644\u0629.<\/p>\n<p>\u0639\u0635\u0627\u0645 \u0627\u0644\u0628\u0627\u0631\u0648\u062f\u064a: \u0628\u0627\u062d\u062b \u0645\u0634\u0627\u0631\u0643\u060c \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0645\u062a\u0639\u0644\u0642 \u0628\u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a.<\/p>\n<p>\u063a\u0632\u0644 \u062f\u064a\u0628: \u0628\u0627\u062d\u062b \u0645\u0634\u0627\u0631\u0643\u060c \u062a\u0633\u0647\u064a\u0644 \u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n<p>\u0644\u0645\u0649 \u064a\u0648\u0633\u0641: \u0627\u0644\u0645\u0634\u0631\u0641 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0641\u064a \u0627\u0644\u0628\u062d\u062b\u060c \u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u062c\u0645\u064a\u0639 \u062a\u0641\u0627\u0635\u064a\u0644 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u062a\u0635\u0645\u064a\u0645 \u062e\u0637\u0629 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u062a\u0648\u062c\u064a\u0647\u0627\u062a \u0641\u064a \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0639\u0645\u0644\u064a \u0648\u062a\u062f\u0642\u064a\u0642 \u0627\u0644\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0646\u0638\u0631\u064a\u0629.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u062a\u0639\u0631\u0651\u0641 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0631\u062c\u064a\u0651\u0629 \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 \u062c\u0645\u0644\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0631\u062f\u0651 \u0641\u0639\u0644 \u0645\u0646\u0627\u0639\u064a\u0651 \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651 \u0634\u062f\u064a\u062f \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u062a\u0639\u0631\u0636 \u0644\u0645\u0633\u062a\u0636\u062f\u0627\u062a \u063a\u064a\u0631 \u0645\u0645\u0631\u0636\u0629 \u0641\u064a&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=2036\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2043,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2036","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-157","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2036"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2036\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2043"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}