{"id":2046,"date":"2025-08-23T08:16:17","date_gmt":"2025-08-23T08:16:17","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2046"},"modified":"2025-08-23T08:16:17","modified_gmt":"2025-08-23T08:16:17","slug":"%d8%aa%d8%ad%d8%b6%d9%8a%d8%b1-%d8%ac%d8%b3%d9%8a%d9%85%d8%a7%d8%aa-%d9%86%d8%a7%d9%86%d9%88%d9%8a%d8%a9-%d9%84%d8%a8%d9%88%d9%84%d9%8a-%d9%83%d8%a7%d8%a8%d8%b1%d9%88%d9%84%d8%a7%d9%83%d8%aa%d9%88","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2046","title":{"rendered":"\u062a\u062d\u0636\u064a\u0631 \u062c\u0633\u064a\u0645\u0627\u062a \u0646\u0627\u0646\u0648\u064a\u0629 \u0644\u0628\u0648\u0644\u064a \u0643\u0627\u0628\u0631\u0648\u0644\u0627\u0643\u062a\u0648\u0646 \u0645\u062d\u0645\u0644\u0629 \u0628\u062d\u0645\u0636 \u0627\u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u0631\u0633\u064a\u0628 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ACROS\u060c \u0623\u0633\u064a\u062a\u0648\u0646\u062a\u0631\u064a\u0644Acetonitrile Scharlau, HPLC\u00a0\u00a0 water for HPLC grade\u060c \u0643\u0644 \u0627\u0644\u0643\u0648\u0627\u0634\u0641 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0630\u0627\u062a \u062f\u0631\u062c\u0629 \u062a\u062d\u0644\u064a\u0644\u064a\u0629 \u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u0640 HPLC.<\/p>\n<p><strong>\u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u0637\u0628\u0642\u0629<\/strong><\/p>\n<ul>\n<li>\u062a\u062d\u0631\u064a \u0627\u0644\u0634\u0643\u0644 \u0648\u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u0633\u0637\u062d:<\/li>\n<\/ul>\n<p>\u064a\u062a\u0645 \u0630\u0644\u0643 \u0628\u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0645\u0627\u0633\u062d SEM, VEGAII-XMU-TESCAN &#8211; Czech\u00a0 Republic\u060c \u0628\u0639\u062f \u0627\u0644\u062a\u0644\u0628\u064a\u0633 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\u064a\u062a\u0645 \u0627\u0644\u0642\u064a\u0627\u0633 \u0639\u0646\u062f \u0637\u0648\u0644 \u0627\u0644\u0645\u0648\u062c\u0629 278 \u0646\u0627\u0646\u0648\u0645\u062a\u0631\u060c \u0648\u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0641\u0631\u0646 25\u00b0 \u0645\u0626\u0648\u064a\u0629\u060c \u062a\u0645\u062a\u0639\u062a \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0628\u0627\u0644\u062e\u0637\u064a\u0629 \u0645\u0646 \u062a\u0631\u0643\u064a\u0632 0.03 \u0645\u0643\u063a\/ \u0645\u0644 \u0648\u062d\u062a\u0649 \u062a\u0631\u0643\u064a\u0632 20 \u0645\u0643\u063a\/ \u0645\u0644\u060c \u0628\u0645\u0639\u0627\u0645\u0644 \u0627\u0631\u062a\u0628\u0627\u0637 0.999\u060c \u0647\u0630\u0647 \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0623\u062c\u0631\u064a\u062a \u062d\u0633\u0628 \u0637\u0631\u064a\u0642\u0629\u00a0 Guterres\u060c [23].<\/p>\n<p>4- \u0645\u0642\u0627\u064a\u0633\u0629 \u0643\u0641\u0627\u0621\u0629 \u0627\u0644\u0643\u0628\u0633\u0644\u0629<\/p>\n<p>\u062a\u0624\u062e\u0630 \u0639\u064a\u0646\u0629 \u0645\u062d\u0636\u0631\u0629 \u0628\u062a\u0645\u062f\u064a\u062f (\u0627 \u0645\u0644) \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0642 \u0627\u0644\u0646\u0627\u0646\u0648\u064a \u0627\u0644\u0645\u062d\u0636\u0631 \u0648\u062a\u0645\u062f\u062f \u0625\u0644\u0649 133 \u0645\u0644 \u0628\u062f\u0627\u0631\u0626\u0629 \u0641\u0648\u0633\u0641\u0627\u062a\u064a\u0629 \u0630\u0627\u062a \u0628\u0627\u0647\u0627\u0621 6.8\u060c \u0648\u062a\u062e\u0636\u0639 \u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0631\u0634\u064a\u062d \u0627\u0644\u0641\u0627\u0626\u0642\/ \u0627\u0644\u062a\u062b\u0641\u064a\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0646\u0627\u0628\u064a\u0628 Amicon ultra-15, 10 k Millipore 10.000 MWCO\u060c \u062a\u062b\u0641\u0644 \u0645\u062f\u0629 \u0646\u0635\u0641 \u0633\u0627\u0639\u0629 \u0648\u0628\u0633\u0631\u0639\u0629 8228 RCF \u0641\u064a \u0645\u062b\u0641\u0644\u0629Eppendorf Centrifuge 5810 R\u060c \u062a\u0641\u062d\u0635 \u0627\u0644\u0631\u0634\u0627\u062d\u0627\u062a \u0628\u062c\u0647\u0627\u0632HPLC JASCO LC-NETII\/ADC \u060c \u0643\u0645\u0627 \u0630\u0643\u0631 \u0623\u0639\u0644\u0627\u0647\u060c \u0648\u062a\u062d\u0633\u0628 \u0643\u0641\u0627\u0621\u0629 \u0627\u0644\u0643\u0628\u0633\u0644\u0629 \u0643\u0645\u0627 \u064a\u0644\u064a:<\/p>\n<p>\u0643\u0641\u0627\u0621\u0629 \u0627\u0644\u0643\u0628\u0633\u0644\u0629 = \u0643\u0645\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u062a\u064a \u062a\u0645\u062a \u0645\u062d\u0641\u0638\u062a\u0647 \u0641\u064a \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 x 100\u00a0 \/ \u0643\u0645\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062f\u062e\u0644 \u0641\u064a \u0627\u0644\u0639\u0645\u0644\u064a\u0629.<\/p>\n<p><strong>\u0637\u0631\u0627\u0626\u0642 \u0627\u0644\u062a\u062d\u0636\u064a\u0631:<\/strong><\/p>\n<p>&#8211; \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629: \u064a\u0636\u0627\u0641 \u0644\u0643\u0644 100 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0645\u0627\u0626\u064a \u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643 \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 1%\u060c 5 \u0645\u0644 \u0645\u0646 \u062d\u0645\u0636 \u0643\u0644\u0648\u0631 \u0627\u0644\u0645\u0627\u0621 1 \u0646\u0638\u0627\u0645\u064a\u060c \u0648\u064a\u062d\u0631\u0643 40 \u062f\u0642\u064a\u0642\u0629 \u062d\u062a\u0649 \u0627\u0646\u062a\u0647\u0627\u0621 \u062a\u0631\u0633\u0628 \u0628\u0644\u0648\u0631\u0627\u062a \u062d\u0645\u0636 \u0627\u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643\u060c \u062a\u0631\u0634\u062d \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0648\u062a\u063a\u0633\u0644 3 \u0645\u0631\u0627\u062a \u0628 100 \u0645\u0644 \u0645\u0627\u0621 \u0631\u0628\u0627\u0639\u064a \u0627\u0644\u062a\u0642\u0637\u064a\u0631\u060c \u062a\u062c\u0641\u0641 \u0641\u064a \u0627\u0644\u0641\u0631\u0646 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 45\u00b0\u0645 \u0644\u0645\u062f\u0629 72 \u0633\u0627\u0639\u0629\u060c \u062b\u0645 \u062a\u0646\u0642\u0649 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0645\u0631\u062a\u064a\u0646 \u0628\u0640 200 \u0645\u0644 \u0645\u0646 \u0645\u0632\u064a\u062c \u0627\u064a\u062b\u0627\u0646\u0648\u0644\/ \u0645\u0627\u0621 \u0631\u0628\u0627\u0639\u064a \u0627\u0644\u062a\u0642\u0637\u064a\u0631 \u0628\u0646\u0633\u0628\u0629 80\/20\u060c \u062a\u062c\u0641\u0641 \u0648\u062a\u062d\u0641\u0638 \u0641\u064a \u0648\u0639\u0627\u0621 \u0639\u0627\u062a\u0645 \u0648\u0645\u062d\u0643\u0645 \u0627\u0644\u0623\u063a\u0644\u0627\u0642.<\/p>\n<p>&#8211; \u062a\u062d\u0636\u064a\u0631 \u062c\u0633\u064a\u0645\u0627\u062a \u0628\u0648\u0644\u064a \u0643\u0627\u0628\u0631\u0648\u0644\u0627\u0643\u062a\u0648\u0646 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u062d\u0645\u0636 \u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u0631\u0633\u064a\u0628 \u0627\u0644\u0646\u0627\u0646\u0648\u064a:<\/p>\n<p>&#8211; \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0639\u0636\u0648\u064a \u0645\u0624\u0644\u0641 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 4 \u0645\u0644 \u064a\u062d\u0648\u064a \u062d\u0645\u0636 \u062f\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643 \u0628\u062a\u0631\u0643\u064a\u0632 1 \u0645\u0644\u063a\/ \u0645\u0644 \u0645\u0639 \u0628\u0648\u0644\u064a \u0643\u0627\u0628\u0631\u0648\u0644\u0627\u0643\u062a\u0648\u0646 45,000 \u0623\u0648 10,000 \u0628\u062a\u0631\u0643\u064a\u0632 10\u0645\u0644\u063a \/ \u0645\u0644 \u0641\u064a 3:1 \u0623\u0633\u064a\u062a\u0648\u0646\/ \u0627\u064a\u062b\u0627\u0646\u0648\u0644.<\/p>\n<p>&#8211; \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0645\u0627\u0626\u064a \u0645\u0624\u0644\u0641 \u0645\u0646 40 \u0645\u0644 \u0645\u0646 \u0645\u062d\u0644\u0648\u0644 \u0645\u0627\u0626\u064a \u0644\u0644\u0648\u062a\u0631\u0648\u0644 \u0625\u0641 68 \u0628\u062a\u0631\u0643\u064a\u0632 1.5%\u060c \u0639\u0644\u0645\u0627\u064b \u0623\u0646 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0639\u0636\u0648\u064a 30\u00b0\u0645 \u0648\u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0645\u0627\u0626\u064a 5 \u00b0\u0645.<\/p>\n<p>\u064a\u0633\u062a\u0644 \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0639\u0636\u0648\u064a \u0641\u064a \u0627\u0644\u0645\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u062a\u062d\u0631\u064a\u0643 \u0644\u0645\u062f\u0629 30 \u062f\u0642\u064a\u0642\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062c\u0627\u0646\u0633 \u062f\u0648\u0627\u0631 \u0646\u0648\u0639 (Ultra Turrax\u00ae T25, Ika.)\u060c \u0628\u0633\u0631\u0639\u0629 21.400 \u062f\/ \u062f\u060c \u064a\u0646\u0642\u0644 \u0627\u0644\u0633\u0627\u0626\u0644 \u0628\u0639\u062f\u0647\u0627 \u0644\u0644\u062a\u062d\u0631\u064a\u0643 \u0628\u0648\u0627\u0633\u0637\u0629 \u062f\u0627\u0641\u0639 \u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a Impeller Marine\u00a0 Propeller\u00a0 \u0628\u0633\u0631\u0639\u0629 600 \u062f\/ \u062f \u0644\u0645\u062f\u0629 \u0633\u0627\u0639\u0629 \u0648\u0646\u0635\u0641\u060c \u0648\u0623\u062e\u064a\u0631\u0627\u064b \u064a\u062a\u0645 \u0646\u0632\u0639 \u0627\u0644\u0645\u0630\u064a\u0628 \u0627\u0644\u0639\u0636\u0648\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0628\u062e\u0631 \u0627\u0644\u062f\u0648\u0627\u0631 \u062a\u062d\u062a \u0627\u0644\u0636\u063a\u0637 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u060c \u0648 \u0627\u0644\u0646\u0627\u062a\u062c \u0627\u0644\u0646\u0647\u0627\u0626\u064a \u0628\u0639\u062f \u0646\u0632\u0639 \u0627\u0644\u0645\u0630\u064a\u0628 \u0647\u0648 10 \u0645\u0644\u060c \u064a\u062c\u0641\u062f \u0627\u0644\u0646\u0627\u062a\u062c \u0648 \u064a\u062d\u0641\u0638 \u0628\u0632\u062c\u0627\u062c\u0627\u062a \u062a\u062c\u0641\u064a\u062f \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 -20\u2e30 \u0645.<\/p>\n<p><strong>\u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a<\/strong><\/p>\n<p>\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u062b\u0644\u0627\u062b \u0645\u0631\u0627\u062a. \u062a\u064f\u0639\u0631\u0636 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0639\u0644\u0649 \u0634\u0643\u0644 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u00b1 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a. \u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 Student\u2019s t-test (p &lt; 0.05).<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong><strong>Results<\/strong><\/p>\n<p>\u064a\u0644\u062e\u0635 \u0627\u0644\u062c\u062f\u0648\u0644 (1) \u0623\u062f\u0646\u0627\u0647 \u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u0628\u0644\u0645\u0631\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0648\u0627\u0644\u0645\u062d\u0645\u0644\u0629 \u0628\u062d\u0645\u0636 \u0627\u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2047 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-2-300x203.png\" alt=\"\" width=\"556\" height=\"376\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-2-300x203.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-2-768x520.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-2.png 912w\" sizes=\"auto, (max-width: 556px) 100vw, 556px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2048 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-1-300x242.png\" alt=\"\" width=\"490\" height=\"395\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-1-300x242.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-1-768x620.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-1.png 868w\" sizes=\"auto, (max-width: 490px) 100vw, 490px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2049 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-1-300x155.png\" alt=\"\" width=\"515\" height=\"266\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-1-300x155.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-1-768x397.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-1.png 903w\" sizes=\"auto, (max-width: 515px) 100vw, 515px\" \/><\/p>\n<p>\u0628\u0646\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u0627\u0633\u0627\u062a \u0627\u0644\u062d\u062c\u0645 \u0648 \u0627\u0644\u0643\u0645\u0648\u0646 \u0627\u0644\u0643\u0647\u0631\u062d\u0631\u0643\u064a \u0627\u0644\u0648\u0627\u0631\u062f \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 1\u060c \u064a\u062a\u0648\u0642\u0639 \u0623\u0646 \u062a\u062a\u062d\u0631\u0631 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0646 PCL45,000\u00a0 \u0639\u0644\u0649 \u0641\u062a\u0631\u0629 \u0632\u0645\u0646\u064a\u0629 \u0623\u0637\u0648\u0644 \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0646 PCL10,000 \u060c \u0648\u0630\u0644\u0643 \u0628\u0633\u0628\u0628 \u062d\u062c\u0645\u0647\u0627 \u0627\u0644\u0623\u0643\u0628\u0631 \u0648\u0648\u0632\u0646\u0647\u0627 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0627\u0644\u0623\u0639\u0644\u0649\u060c \u0643\u0645\u0627 \u064a\u062a\u0648\u0642\u0639 \u0623\u0646 \u062a\u062d\u0642\u0642 \u062b\u0628\u0627\u062a\u0627\u064b \u0623\u0639\u0644\u0649 \u0641\u064a \u0627\u0644\u0648\u0633\u0637 \u0627\u0644\u0645\u0627\u0626\u064a \u0648 \u0627\u0644\u062d\u064a\u0648\u064a\u060c \u0628\u0633\u0628\u0628 \u0627\u0645\u062a\u0644\u0627\u0643\u0647\u0627 \u0643\u0645\u0648\u0646\u0627\u064b \u0643\u0647\u0631\u062d\u0631\u0643\u064a\u0627\u064b \u0623\u0639\u0644\u0649\u060c \u0644\u0630\u0627 \u0641\u0642\u062f \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u0630\u0643\u0648\u0631\u0629 \u0644\u062a\u062d\u0631\u064a \u062d\u0631\u0643\u064a\u0627\u062a \u062a\u062d\u0631\u0631\u0647\u0627 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c.<\/p>\n<p>\u062a\u0645\u062a \u062f\u0631\u0627\u0633\u0629 \u062d\u0631\u0627\u0626\u0643 \u062a\u062d\u0631\u0631 \u062d\u0645\u0636 \u0627\u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643 \u0645\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0628\u0644\u0645\u0631\u064a\u0629 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u0628\u0648\u0644\u064a \u0643\u0627\u0628\u0631\u0648\u0644\u0627\u0643\u062a\u0648\u0646 \u0630\u064a \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0627\u0644\u0639\u062f\u062f\u064a 45,000 \u062e\u0644\u0627\u0644 66 \u0633\u0627\u0639\u0629 \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0645\u0643\u0627\u0646\u064a\u0629 \u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0641\u064a \u0623\u0646\u0638\u0645\u0629 \u0627\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u062f\u064a\u062f\u0629 [24-26]\u060c \u0648\u0630\u0644\u0643 \u0644\u062a\u0641\u0648\u0642\u0647 \u0641\u064a \u0627\u0645\u062a\u0644\u0627\u0643 \u0643\u0645\u0648\u0646 \u0643\u0647\u0631\u062d\u0631\u0643\u064a \u0645\u0631\u062a\u0641\u0639 \u0641\u0627\u0642 30 \u0645\u064a\u0644\u0644\u064a \u0641\u0648\u0644\u062a [27] \u0627\u0644\u0630\u064a \u064a\u062f\u0644 \u0639\u0644\u0649 \u062a\u0628\u0627\u062a\u0647\u060c \u0648\u0630\u0644\u0643 \u0628\u0647\u062f\u0641 \u0627\u0644\u062a\u0646\u0628\u0624 \u0628\u0627\u0644\u0633\u0644\u0648\u0643 \u0627\u0644\u0630\u064a \u064a\u062a\u0628\u0639\u0647 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629\u060c \u0628\u062d\u0633\u0627\u0628 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u00a0 R\u00b2\u060c \u062d\u064a\u062b \u062a\u0638\u0647\u0631 \u0642\u064a\u0645 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0644\u0646\u0645\u0627\u0630\u062c \u0627\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u062e\u0645\u0633\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (2)\u060c \u064a\u062a\u0645 \u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u062a\u0631\u0627\u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u064a\u0627\u0646\u064a\u0627\u064b \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0632\u0645\u0646 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0631\u062a\u0628\u0629 \u0635\u0641\u0631 \u00a0Zero-order model\u060c \u0643\u0645\u0627 \u064a\u062a\u0645 \u062a\u0645\u062b\u064a\u0644 \u0644\u0648\u063a\u0627\u0631\u064a\u062a\u0645 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0632\u0645\u0646 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0627\u0644\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0631\u062a\u0628\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 First-order model\u060c \u0628\u064a\u0646\u0645\u0627 \u064a\u062a\u0645 \u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u062a\u0631\u0627\u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u062c\u0630\u0631 \u0627\u0644\u062a\u0631\u0628\u064a\u0639\u064a \u0644\u0644\u0632\u0645\u0646 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0647\u064a\u063a\u0648\u0634\u064a Higuchi model\u060c \u0648\u062a\u0645\u062b\u064a\u0644 \u0644\u0648\u063a\u0627\u0631\u064a\u062a\u0645 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u062a\u0631\u0627\u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u064a\u0627\u0646\u064a\u0627\u064b \u0645\u0642\u0627\u0628\u0644 \u0644\u0648\u063a\u0627\u0631\u064a\u062a\u0645 \u0627\u0644\u0632\u0645\u0646 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0643\u0648\u0631\u0633\u0645\u0627\u064a\u0631 \u0628\u064a\u0628\u0627\u0633 Korsmeyer-Peppas model\u060c \u0623\u0645\u0627 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0647\u064a\u0643\u0633\u0648\u0646 \u0643\u0631\u0648\u064a\u0644Hixson Crowell \u00a0\u0641\u064a\u062a\u0645 \u062a\u0645\u062b\u064a\u0644\u0647 \u0628\u064a\u0627\u0646\u064a\u0627\u064b \u0628\u0627\u0644\u062c\u0630\u0631 \u0627\u0644\u062a\u0643\u0639\u064a\u0628\u064a \u0644\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629 \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646\u0642\u0648\u0635\u0629 \u0645\u0646 \u0627\u0644\u062c\u0630\u0631 \u0627\u0644\u062a\u0643\u0639\u064a\u0628\u064a \u0644\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0628\u062f\u0626\u064a\u0629 \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0632\u0645\u0646\u060c \u0648\u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0630\u0648 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0623\u0639\u0644\u0649 \u0647\u0648 \u0627\u0644\u0623\u0641\u0636\u0644 \u062a\u0645\u062b\u064a\u0644\u0627\u064b \u0644\u062d\u0631\u0643\u064a\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 [28].<\/p>\n<p>\u062a\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u062e\u0645\u0633\u0629 \u0646\u0645\u0627\u0630\u062c \u0631\u064a\u0627\u0636\u064a\u0629 (Zero-order, First-order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell)\u060c \u0648\u062d\u0633\u0627\u0628 \u0645\u0639\u0627\u0645\u0644\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 (R\u00b2) \u0644\u0643\u0644 \u0646\u0645\u0648\u0630\u062c \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (2).<\/p>\n<p>\u064a\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0648\u0644 (2) \u0623\u0646 \u0645\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0623\u0639\u0644\u0649 \u0642\u062f \u062a\u062d\u0642\u0642 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0643\u0648\u0631\u0633\u0645\u0627\u064a\u0631 \u0628\u064a\u0628\u0627\u0633<strong>\u060c<\/strong> \u0648\u062a\u062f\u0644 \u0642\u064a\u0645\u0629n \u00a0\u0639\u0644\u0649 \u0622\u0644\u064a\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u062d\u064a\u062b \u062a\u0638\u0647\u0631 \u0641\u064a \u0627\u0644\u062d\u0627\u0644\u0629 \u0623\u062f\u0646\u0627\u0647 \u0623\u0646 \u0642\u064a\u0645\u062a\u0647\u0627 \u0623\u0642\u0644 \u0645\u0646 0.5\u060c \u0645\u0645\u0627 \u064a\u062f\u0644 \u0623\u0646 \u0622\u0644\u064a\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0647\u064a \u0628\u0622\u0644\u064a\u0629 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 [29]<strong>.<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2050 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4-1-300x133.png\" alt=\"\" width=\"544\" height=\"241\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4-1-300x133.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4-1-768x341.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/4-1.png 897w\" sizes=\"auto, (max-width: 544px) 100vw, 544px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2051 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/5-2-292x300.png\" alt=\"\" width=\"431\" height=\"443\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/5-2-292x300.png 292w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/5-2.png 727w\" sizes=\"auto, (max-width: 431px) 100vw, 431px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Discussion<\/strong><\/p>\n<p>\u0623\u0638\u0647\u0631\u062a \u062c\u0633\u064a\u0645\u0627\u062a PCL10,000 \u0646\u0635\u0641 \u0642\u0637\u0631 \u0647\u064a\u062f\u0631\u0648\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u064a \u0623\u0635\u063a\u0631 (62.89\u00b10.57 \u0646\u0627\u0646\u0648\u0645\u062a\u0631) \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u062c\u0633\u064a\u0645\u0627\u062a \u00a0PCL45,000 (87.47\u00b12.72 \u0646\u0627\u0646\u0648\u0645\u062a\u0631)\u060c \u0648\u0630\u064a \u062f\u0644\u0627\u0644\u0629 \u0627\u062d\u0635\u0627\u0626\u064a\u0629 \u0645\u0639 \u0628\u0642\u0627\u0621 \u0645\u0624\u0634\u0631 \u0627\u0644\u062a\u0628\u0639\u062b\u0631 \u0627\u0644\u0645\u062a\u0639\u062f\u062f (PDI) \u00a0\u0645\u0646\u062e\u0641\u0636\u064b\u0627 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u0646\u0638\u0627\u0645\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u062a\u062c\u0627\u0646\u0633 \u0639\u0627\u0644\u064a.<\/p>\n<p>\u0643\u0645\u0627 \u062d\u0642\u0642\u062a \u062c\u0633\u064a\u0645\u0627\u062aPCL10,000 \u00a0\u0643\u0641\u0627\u0621\u0629 \u0643\u0628\u0633\u0644\u0629 \u0628\u0644\u063a\u062a 95.31%\u060c \u0648\u0647\u064a \u0623\u0639\u0644\u0649 \u0628\u0634\u0643\u0644 \u0648\u0627\u0636\u062d \u0645\u0646 \u00a0(76.52%) \u0644\u062c\u0633\u064a\u0645\u0627\u062a PCL45,000 \u060c \u0648\u0647\u0630\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0627\u0644\u0645\u0646\u062e\u0641\u0636 \u0644\u0644\u0628\u0644\u0645\u0631 \u064a\u0639\u0632\u0632 \u0645\u0646 \u0642\u062f\u0631\u0629 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0639\u0644\u0649 \u0627\u062d\u062a\u0648\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0631\u0628\u0645\u0627 \u0628\u0633\u0628\u0628\u00a0 \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u0627\u0644\u0628\u0646\u064a\u0629 \u0627\u0644\u062f\u0627\u062e\u0644\u064a\u0629 \u0644\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0645\u0630\u064a\u0628 \u0627\u0644\u0639\u0636\u0648\u064a \u0645\u0639 \u0627\u0644\u0648\u0633\u0637 \u0627\u0644\u0645\u0627\u0626\u064a \u062e\u0644\u0627\u0644 \u0645\u0631\u062d\u0644\u0629 \u062a\u0634\u0643\u0644 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a\u060c \u0623\u0648 \u0628\u0633\u0628\u0628 \u0627\u062e\u062a\u0644\u0627\u0641 \u0623\u0644\u0641\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0639 \u0627\u0644\u0628\u0644\u0645\u0631 \u0628\u0627\u062e\u062a\u0644\u0627\u0641 \u0623\u0648\u0632\u0627\u0646\u0647 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646 \u0643\u0641\u0627\u0621\u0629 \u0627\u0644\u0643\u0628\u0633\u0644\u0629 \u0641\u064a \u0643\u0644\u062a\u0627 \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 \u062a\u062f\u0644\u0627\u0646 \u0639\u0644\u0649 \u0642\u062f\u0631\u0629 \u0627\u0644\u0628\u0644\u0645\u0631 \u0628\u0648\u0632\u0646\u064a\u0647 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u064a\u0646 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u064a\u0646 \u0639\u0644\u0649 \u0627\u062d\u062a\u0648\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621 \u0636\u0645\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629.<\/p>\n<p>\u062d\u0642\u0642\u062a \u062c\u0633\u064a\u0645\u0627\u062a PCL45,000 \u0642\u064a\u0645\u0629 \u062c\u0647\u062f \u0643\u0647\u0631\u0648\u062d\u0631\u0643\u064a (-31.7\u00b11.82 \u0645\u064a\u0644\u064a \u0641\u0648\u0644\u062a)\u00a0<strong>\u0623\u0639\u0644\u0649 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638<\/strong>\u00a0\u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0640 PCL10,000 \u00a0(-17\u00b14.2 \u0645\u064a\u0644\u064a \u0641\u0648\u0644\u062a)\u060c \u0645\u0645\u0627 \u064a\u0639\u0643\u0633 \u0642\u0648\u0629 \u062a\u0646\u0627\u0641\u0631 \u0643\u0647\u0631\u0648\u0633\u062a\u0627\u062a\u064a\u0643\u064a \u0623\u0643\u0628\u0631 \u0628\u064a\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a. \u0648\u064a\u0639\u062a\u0628\u0631 \u0647\u0630\u0627 \u0627\u0644\u0639\u0627\u0645\u0644 \u0647\u0627\u0645\u0627\u064b \u0641\u064a \u062a\u0639\u0632\u064a\u0632 \u062b\u0628\u0627\u062a\u064a\u0629 \u0627\u0644\u0645\u0639\u0644\u0642 \u0627\u0644\u0646\u0627\u0646\u0648\u064a \u0648\u0645\u0646\u0639 \u062a\u0643\u062a\u0644\u0647 \u0641\u064a \u0627\u0644\u0623\u0648\u0633\u0627\u0637 \u0627\u0644\u0645\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u00a0[30]<\/p>\n<p>\u0641\u0628\u0630\u0644\u0643 \u062a\u0634\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0623\u0646 \u062c\u0633\u064a\u0645\u0627\u062a \u0628\u0648\u0644\u064a \u0643\u0627\u0628\u0631\u0648\u0644\u0627\u0643\u062a\u0648\u0646 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0648 \u0627\u0644\u0645\u062d\u0645\u0644\u0629 \u0628\u062d\u0645\u0636 \u0627\u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0643 \u0648\u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u0631\u0633\u064a\u0628 \u0627\u0644\u0646\u0627\u0646\u0648\u064a \u062a\u062a\u0645\u064a\u0632 \u0628\u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0643\u0631\u0648\u064a \u0648\u0628\u062a\u062c\u0627\u0646\u0633 \u062d\u062c\u0645\u064a \u0639\u0627\u0644\u064d \u0648\u062d\u062c\u0645 \u0645\u0646\u0627\u0633\u0628 \u0644\u062a\u0637\u0628\u064a\u0642\u0627\u062a \u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u062d\u064a\u062b \u0623\u0646 \u0627\u0644\u0642\u0637\u0631 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0641\u064a \u0643\u0644\u062a\u0627 \u0627\u0644\u0635\u064a\u063a\u062a\u064a\u0646 \u0643\u0627\u0646 \u0623\u0642\u0644 \u0645\u0646 200 \u0646\u0627\u0646\u0648\u0645\u062a\u0631\u060c \u0648\u0647\u0648 \u0645\u062b\u0627\u0644\u064a \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u062d\u0648\u0627\u062c\u0632 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0648\u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u062e\u0644\u0648\u064a [31]<\/p>\n<p>\u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643 \u0645\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0644 PCL45 \u00a0\u0628\u062f\u0627\u064a\u0629\u064b \u0628\u0634\u0643\u0644 \u0627\u0646\u0641\u062c\u0627\u0631\u064a \u0633\u0631\u064a\u0639 \u062b\u0645 \u0623\u0635\u0628\u062d \u0645\u0637\u0648\u0644\u0627\u064b\u060c \u0648\u0642\u062f \u064a\u0639\u0632\u0649 \u0628\u062a\u062d\u0631\u0631\u0647 \u0633\u0631\u064a\u0639 \u0641\u064a \u0627\u0644\u0628\u062f\u0627\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u0648\u0636\u0639 <strong>\u0642\u0631\u0628<\/strong> \u0633\u0637\u062d \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629\u060c \u062b\u0645 \u062a\u0628\u0639\u0647 \u062a\u062d\u0631\u0631 \u0645\u0637\u0648\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u062a\u0648\u0627\u062c\u062f \u0636\u0645\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0648\u0627\u0644\u0645\u062d\u0627\u0637 \u0628\u0628\u0644\u0645\u0631 \u0643\u0627\u0631\u0647 \u0644\u0644\u0645\u0627\u0621 \u0628\u0637\u064a\u0621 \u0627\u0644\u062a\u062f\u0631\u0643 \u0648\u0639\u0627\u0644\u064a \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u060c \u0648\u0642\u062f \u064a\u0639\u0632\u0649 \u0623\u064a\u0636\u0627\u064b \u0644\u062a\u062f\u0631\u0643 \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0644\u0627\u0628\u0644\u0648\u0631\u064a \u0642\u0628\u0644 \u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0628\u0644\u0648\u0631\u064a \u0645\u0646 \u0627\u0644\u0628\u0644\u0645\u0631 [32]\u060c \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u062a\u062d\u0643\u0645 \u0641\u064a\u0647 \u064a\u0639\u062a\u0628\u0631 \u0645\u064a\u0632\u0629 \u0647\u0627\u0645\u0629 \u0644\u0623\u0646\u0638\u0645\u0629 \u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629\u060c \u062d\u064a\u062b \u064a\u062a\u064a\u062d \u0625\u0637\u0644\u0627\u0642\u0627\u064b \u0633\u0631\u064a\u0639\u0627\u064b \u0644\u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u062d\u064a\u062b \u064a\u062d\u0642\u0642 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u060c \u062b\u0645 \u064a\u062a\u0628\u0639\u0647 \u062a\u062d\u0631\u0631 \u062a\u062f\u0631\u064a\u062c\u064a \u0628\u062d\u064a\u062b \u064a\u062d\u0627\u0641\u0638 \u0639\u0644\u064a\u0647 \u062b\u0627\u0628\u062a\u0627\u064b \u0644\u0641\u062a\u0631\u0629 \u0623\u0637\u0648\u0644 \u0645\u0646 \u0627\u0644\u0632\u0645\u0646\u060c \u0645\u0645\u0627 \u064a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062c\u0631\u0639\u064a \u0648\u064a\u062d\u062f \u0645\u0646 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629\u060c \u062d\u064a\u062b \u064a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0628\u0644\u0627\u0633\u0645\u064a\u0629 \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0633\u0628\u0628\u0647\u0627 \u0627\u0644\u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062c\u0631\u0639\u064a.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/p>\n<p>\u062a\u0645\u062a \u0643\u0628\u0633\u0644\u0629 \u062d\u0645\u0636 \u0627\u0644\u062f\u064a\u0643\u0644\u0648\u0641\u064a\u0646\u0627\u0643 \u0628\u0646\u062c\u0627\u062d \u0636\u0645\u0646 \u062c\u0633\u064a\u0645\u0627\u062a \u0646\u0627\u0646\u0648\u064a\u0629 \u0628\u0644\u0645\u0631\u064a\u0629 \u0644\u0628\u0648\u0644\u064a \u0643\u0627\u0628\u0631\u0648\u0644\u0627\u0643\u062a\u0648\u0646 \u00a010,000\u0648\u0644\u0628\u0648\u0644\u064a \u0643\u0627\u0628\u0631\u0648\u0644\u0627\u0643\u062a\u0648\u0646 45,000 \u0627\u0644\u0630\u064a \u064a\u062a\u0645\u064a\u0632 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\u0648\u0623\u062f\u0627\u0626\u0647\u0627 \u0648\u062a\u0648\u0632\u0639\u0647\u0627 \u0636\u0645\u0646 \u0627\u0644\u0639\u0636\u0648\u064a\u0629 \u0627\u0644\u062d\u064a\u0629\u060c \u0648\u0639\u0646 \u0645\u0644\u0627\u0621\u0645\u062a\u0647\u0627 \u0644\u0644\u062a\u0637\u0628\u064a\u0642 \u0639\u0628\u0631 \u0646\u0638\u0645 \u0627\u0644\u0625\u064a\u062a\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 <\/strong><strong>Ethics approval and consent to participate<\/strong><\/p>\n<p>\u063a\u064a\u0631 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong><strong>Conflict of Interests<\/strong><\/p>\n<p>\u064a\u0642\u0631 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong><strong>Funding<\/strong><\/p>\n<p>\u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong><strong>Authors\u2019 contributions<\/strong><\/p>\n<p>\u0633\u0644\u0627\u0641\u0629 \u0627\u0644\u0633\u0644\u064a\u0645\u0627\u0646: \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u0627\u0633\u062a\u0642\u0635\u0627\u0621 \u062e\u0635\u0627\u0626\u0635\u0647\u0627 \u0648\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631.<\/p>\n<p>\u0627\u0644\u0623\u0633\u062a\u0627\u0630 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0623\u0646\u0637\u0648\u0646 \u0627\u0644\u0644\u062d\u0627\u0645: \u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u0628\u062d\u062b\u064a \u0648\u0627\u0644\u062f\u0639\u0645 \u0627\u0644\u062a\u0642\u0646\u064a \u0648\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631.<\/p>\n<p>\u0627\u0644\u0623\u0633\u062a\u0627\u0630 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0632\u0643\u064a \u0639\u0644\u064a \u0639\u062c\u064a \u0627\u0644\u062f\u0639\u0645 \u0627\u0644\u062a\u0642\u0646\u064a \u0648\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0644\u0642\u062f \u0623\u062d\u062f\u062b\u062a \u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0646\u0627\u0646\u0648 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\u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2052,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2046","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-157","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2046"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2046\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2052"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}