{"id":2054,"date":"2025-08-23T08:17:04","date_gmt":"2025-08-23T08:17:04","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2054"},"modified":"2025-08-23T08:17:04","modified_gmt":"2025-08-23T08:17:04","slug":"%d8%aa%d8%ad%d8%b6%d9%8a%d8%b1-%d9%85%d8%b3%d8%aa%d8%ad%d9%84%d8%a8%d8%a7%d8%aa-%d9%85%d9%8a%d9%83%d8%b1%d9%88%d9%8a%d8%a9-%d9%85%d9%86-%d8%a7%d9%84%d9%83%d9%84%d9%88%d8%b2%d8%a7%d8%a8%d9%8a%d9%86","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2054","title":{"rendered":"\u062a\u062d\u0636\u064a\u0631 \u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0623\u0646\u0641\u064a\u0651 \u0648\u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c"},"content":{"rendered":"<p><strong>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 <\/strong><strong>Introduction<\/strong><\/p>\n<p>\u0648\u0641\u0642\u064b\u0627 \u0644\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 (WHO)\u060c \u064a\u0639\u0627\u0646\u064a \u062d\u0648\u0627\u0644\u064a 20 \u0645\u0644\u064a\u0648\u0646 \u0634\u062e\u0635 \u0645\u0646 \u0645\u0631\u0636 \u0627\u0644\u0641\u0635\u0627\u0645 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645\u060c \u0643\u0645\u0627 \u0623\u0646 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0641\u0635\u0627\u0645 \u064a\u0645\u0648\u062a\u0648\u0646 \u0641\u064a \u0633\u0646 \u0645\u0628\u0643\u0631\u0629\u060c \u0628\u062a\u0648\u0627\u062a\u0631 3-4 \u0645\u0631\u0627\u062a \u0623\u0639\u0644\u0649 \u0645\u0646 \u0639\u0627\u0645\u0629 \u0627\u0644\u0633\u0643\u0627\u0646.<\/p>\n<p>\u064a\u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0628\u0633\u0628\u0628 \u0627\u0644\u062a\u063a\u064a\u0631 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0646\u0648\u0627\u0642\u0644 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u062f\u0645\u0627\u063a\u060c \u0645\u062b\u0644 \u0627\u0644\u062f\u0648\u0628\u0627\u0645\u064a\u0646 \u0648\u0627\u0644\u0633\u064a\u0631\u0648\u062a\u0648\u0646\u064a\u0646.<\/p>\n<p>\u0627\u0646 \u0627\u0644\u0633\u0628\u0628 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0644\u062a\u0637\u0648\u0631 \u0627\u0644\u0641\u0635\u0627\u0645 \u0647\u0648 \u0632\u064a\u0627\u062f\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062f\u0648\u0628\u0627\u0645\u064a\u0646 \u0641\u064a \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0646\u0648\u0627\u0629 \u0627\u0644\u0645\u062a\u0643\u0626\u0629 Nucleus Accumbens)) \u0641\u064a \u0627\u0644\u062f\u0645\u0627\u063a\u060c \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u064a\u0624\u062f\u064a \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062f\u0648\u0628\u0627\u0645\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0623\u0645\u0627\u0645\u064a\u0629 \u0627\u0644\u0635\u062f\u063a\u064a\u0629 \u0645\u0646 \u0627\u0644\u062f\u0645\u0627\u063a \u0641\u064a \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0625\u0644\u0649 \u0638\u0647\u0648\u0631 \u0623\u0639\u0631\u0627\u0636 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0648\u0633\u0644\u0628\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a\u060c \u0625\u0630 \u062a\u0647\u062f\u0641 \u0637\u0631\u0627\u0626\u0642 \u0627\u0644\u0639\u0644\u0627\u062c \u0625\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062f\u0648\u0628\u0627\u0645\u064a\u0646 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646 \u0641\u0631\u0637 \u0627\u0644\u0646\u0634\u0627\u0637 .[1]<\/p>\n<p>\u0630\u0647\u0627\u0646 \u063a\u064a\u0631 \u0646\u0645\u0637\u064a \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0645\u0639\u062a\u0645\u062f \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0641\u0635\u0627\u0645 \u0627\u0644\u0645\u0642\u0627\u0648\u0645 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 .[2]<\/p>\n<p>\u064a\u0624\u062b\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0647\u0636\u0629 \u0644\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a D<sub>2<\/sub> \u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u062d\u0648\u0641\u064a \u0627\u0644\u0645\u062a\u0648\u0633\u0637\u060c \u0648\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a 5-HT<sub>2<\/sub>A \u0641\u064a \u0627\u0644\u0642\u0634\u0631\u0629 \u0627\u0644\u0623\u0645\u0627\u0645\u064a\u0629. \u0625\u0646\u0651 \u062d\u062c\u0628 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a D<sub>2<\/sub> \u064a\u062e\u0641\u0651\u0641 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0628\u064a\u0646\u0645\u0627 \u062d\u062c\u0628 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a 5-HT<sub>2<\/sub>A \u064a\u062e\u0641\u0641 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0633\u0644\u0628\u064a\u0629.<\/p>\n<p>\u064a\u0635\u0644 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0645\u0645\u062a\u0635 \u0645\u0646 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a \u0628\u0650\u0646\u0650\u0633\u0628 \u0636\u0626\u064a\u0644\u0629 \u0628\u0633\u0628\u0628:<\/p>\n<p>\u0627\u0644\u062d\u0627\u062c\u0632 \u0627\u0644\u062f\u0645\u0648\u064a \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u060c \u064a\u062a\u062e\u0631\u0651\u0628 \u0641\u064a \u0628\u064a\u0626\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a \u0627\u0644\u0642\u0627\u0633\u064a\u0629\u060c \u0648\u0627\u0644\u0645\u0631\u0648\u0631 \u0627\u0644\u0643\u0628\u062f\u064a \u0627\u0644\u0623\u0648\u0644.<\/p>\n<p>\u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0643\u0627\u0631\u0647 \u0644\u0644\u0645\u0627\u0621\u060c \u062a\u0648\u0627\u0641\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a \u0623\u0642\u0644 \u0645\u0646 (27%) \u0628\u0633\u0628\u0628 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u0643\u0628\u062f\u064a \u0627\u0644\u0623\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u064a \u0628\u0648\u0627\u0633\u0637\u0629 \u00a0CYP1A2 \u0648CYP3A4\u060c \u0644\u062a\u0643\u0648\u064a\u0646 \u0646\u0648\u0631\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 (Norclozapine) \u0623\u0648 N-desmethylclozapine\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0628 \u0627\u0644\u0631\u0626\u064a\u0633\u064a 20-30%)) [3].<\/p>\n<p>\u0644\u0627 \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u062e\u0637 \u0627\u0644\u0623\u0648\u0644 \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0623\u0646\u0647 \u0642\u062f \u064a\u0643\u0648\u0646 \u0645\u0646 \u0627\u0644\u0635\u0639\u0628 \u0641\u064a \u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0623\u062d\u064a\u0627\u0646 \u0639\u0644\u0649 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u062a\u062d\u0645\u0644\u0647 \u0644\u0623\u0646 \u0628\u0639\u0636 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u062e\u0637\u0631\u0629 \u0648\u0645\u0647\u062f\u062f\u0629 \u0644\u0644\u062d\u064a\u0627\u0629 \u0645\u062b\u0644 (\u0627\u0644\u062a\u062e\u062f\u064a\u0631\u060c \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0648\u0632\u0646\u060c \u0633\u064a\u0644\u0627\u0646 \u0627\u0644\u0644\u0639\u0627\u0628\u060c \u0627\u0644\u062a\u0647\u0627\u0628 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628\u060c \u0648\u0627\u0644\u0646\u0648\u0628\u0627\u062a \u0627\u0644\u0635\u0631\u0639\u064a\u0629\u060c \u0648\u0646\u062f\u0631\u0629 \u0627\u0644\u0645\u062d\u0628\u0628\u0627\u062a ((agranulocytosis\u060c \u0648\u0646\u0642\u0635 \u0627\u0644\u062d\u0631\u0643\u0629 \u0627\u0644\u0645\u0639\u062f\u064a\u0629 \u0627\u0644\u0645\u0639\u0648\u064a\u0629) [4].<\/p>\n<p>\u064a\u062a\u0648\u0642\u0641 (69-82%) \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0646 \u062a\u0646\u0627\u0648\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0633\u0628\u0628 \u0622\u062b\u0627\u0631\u0647 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u0627 \u062a\u064f\u062d\u062a\u064e\u0645\u064e\u0644 .[3]<\/p>\n<p>\u0644\u062a\u062c\u0646\u0628 \u0627\u0644\u0645\u0631\u0648\u0631 \u0627\u0644\u0643\u0628\u062f\u064a \u0627\u0644\u0623\u0648\u0644 \u0648\u0643\u0630\u0644\u0643 \u0644\u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0648\u0643\u0641\u0627\u0621\u0629 \u0627\u0644\u062a\u0647\u062f\u064a\u0641 \u0627\u0644\u062f\u0645\u0627\u063a\u064a \u0644\u0640\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646\u060c \u064a\u0646\u0628\u063a\u064a \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u0637\u0631\u0627\u0626\u0642 \u0628\u062f\u064a\u0644\u0629 \u0644\u0644\u0625\u064a\u062a\u0627\u0621 [5].<\/p>\n<p>\u0641\u064a \u0627\u0644\u0622\u0648\u0646\u0629 \u0627\u0644\u0623\u062e\u064a\u0631\u0629\u060c \u0627\u0643\u062a\u0633\u0628 \u0627\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0628\u0627\u0644\u0637\u0631\u064a\u0642 \u0627\u0644\u0623\u0646\u0641\u064a \u0644\u062a\u0647\u062f\u064a\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a\u060c \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u062d\u0627\u062c\u0632 \u0627\u0644\u062f\u0645\u0648\u064a \u0627\u0644\u062f\u0645\u0627\u063a\u064a \u0623\u0647\u0645\u064a\u0629\u060c \u0628\u0641\u0636\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0641\u0631\u064a\u062f \u0628\u064a\u0646 \u0627\u0644\u0623\u0646\u0641 \u0648\u0627\u0644\u062f\u0645\u0627\u063a \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0633\u0627\u0631 \u0627\u0644\u0639\u0635\u0628 \u0627\u0644\u0634\u0645\u064a [3].<\/p>\n<p>\u064a\u0645\u0643\u0646 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0623\u0646 \u062a\u0646\u062a\u0634\u0631 \u0628\u0633\u0647\u0648\u0644\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645\u060c \u0628\u064a\u0646\u0645\u0627 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0630\u0648\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u062f\u0633\u0645\u060c \u0636\u0639\u064a\u0641\u0629 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0641\u064a \u0627\u0644\u0645\u0627\u0621\u060c \u062a\u0648\u0627\u0641\u0631\u0647\u0627 \u0627\u0644\u062d\u064a\u0648\u064a \u0645\u0646\u062e\u0641\u0636. \u062a\u0639\u062a\u0628\u0631 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0646\u0638\u0645\u0629 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0643\u0627\u0631\u0647\u0629 \u0644\u0644\u0645\u0627\u0621\u060c \u062d\u064a\u062b \u0623\u0646\u0647\u0627 \u062b\u0627\u0628\u062a\u0629 \u062d\u0631\u0627\u0631\u064a\u0627\u064b\u060c \u0648\u0644\u0647\u0627 \u062e\u0635\u0627\u0626\u0635 \u0641\u0631\u064a\u062f\u0629\u060c \u0625\u0630 \u062a\u062a\u0645\u062a\u0639 \u0628\u0623\u0628\u0639\u0627\u062f \u0642\u0637\u064a\u0631\u0627\u062a \u0635\u063a\u064a\u0631\u0629 (\u0623\u0628\u0639\u0627\u062f \u0646\u0627\u0646\u0648\u064a\u0629)\u060c \u0648\u062b\u0628\u0627\u062a \u0639\u0627\u0644\u064a\u060c \u0648\u0645\u0633\u0627\u062d\u0629 \u0633\u0637\u062d \u0648\u0627\u0633\u0639\u0629\u060c \u0648\u062a\u0648\u062a\u0631 \u0633\u0637\u062d\u064a \u0645\u0646\u062e\u0641\u0636 \u0648\u062a\u062a\u0634\u0643\u0644 \u0639\u0641\u0648\u064a\u0627\u064b Spontaneously [6].<\/p>\n<p>\u064a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0625\u0644\u0649 \u0635\u064a\u0627\u063a\u0629 \u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0644\u0644\u0625\u064a\u062a\u0627\u0621 \u0627\u0644\u0623\u0646\u0641\u064a\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0633\u0648\u0627\u063a\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0644\u062a\u063a\u0644\u0628 \u0639\u0644\u0649 \u0636\u0639\u0641 \u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0648\u062a\u062d\u0633\u064a\u0646 \u062a\u0648\u0627\u0641\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a\u060c \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u062a\u062c\u0646\u0628 \u0647\u0630\u0627 \u0627\u0644\u0637\u0631\u064a\u0642 \u0623\u064a\u0636\u0627\u064b \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0645\u0631\u0648\u0631 \u0627\u0644\u0643\u0628\u062f\u064a \u0627\u0644\u0623\u0648\u0644 \u0648\u064a\u0648\u0641\u0631 \u0637\u0631\u064a\u0642\u0629 \u0639\u0645\u0644\u064a\u0651\u0629 \u0648\u063a\u064a\u0631 \u062c\u0631\u0627\u062d\u064a\u0629 \u0648\u0641\u0639\u0627\u0644\u0629 \u0644\u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u062a\u062d\u0631\u0651\u0631 \u0645\u062f\u064a\u062f \u0644\u0644\u062f\u0648\u0627\u0621 \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a\u060c \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0646 \u062d\u064a\u062b \u062e\u0635\u0627\u0626\u0635\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a\u0629\u060c \u0648\u0645\u0646 \u062b\u0645 \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u064a \u062a\u062d\u0642\u0642 \u0623\u0641\u0636\u0644 \u0627\u0644\u062e\u0635\u0627\u0626\u0635.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Materials and methods<\/strong><\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f<\/strong><strong>Materials <\/strong><strong>:<\/strong><\/p>\n<p>\u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 Clozapine)) \u0645\u0646 (Global Calcium, India)<\/p>\n<p>\u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a Oleic Acid)) \u0645\u0646 (Panreac corp, Spain)<\/p>\n<p>\u0627\u064a\u0632\u0648\u0628\u0631\u0648\u0628\u064a\u0644 \u0645\u064a\u0631\u064a\u0633\u062a\u0627\u062a (Isopropyl Myristate) \u0645\u0646 (Cisme, Italy)<\/p>\n<p>\u0632\u064a\u062a \u062f\u0648\u0627\u0631 \u0627\u0644\u0634\u0645\u0633 \u0645\u0646 (Croda, India)<\/p>\n<p>\u0628\u0631\u0648\u0628\u064a\u0644\u064a\u0646 \u063a\u0644\u064a\u0643\u0648\u0644 propylene glycol)) \u0648\u0627\u0644\u063a\u0644\u064a\u0633\u064a\u0631\u064a\u0646(Glycerin) \u00a0\u0645\u0646 Hutong Global, China))<\/p>\n<p>\u0628\u0648\u0644\u064a \u0627\u064a\u062a\u0644\u064a\u0646 \u063a\u0644\u064a\u0643\u0648\u0644 400 polyethylene glycol 400)) \u0645\u0646 (Sigma-Aldrich, Germany)<\/p>\n<p>\u062a\u0648\u064a\u0646 80 \u064820 Tween 80,20)) \u0645\u0646 Riedel-de Haen, Germany))<\/p>\n<p><strong>\u0627\u0644\u0637\u0631\u0627\u0626\u0642<\/strong><strong>Methods <\/strong><strong>:<\/strong><\/p>\n<p><strong>\u062f\u0631\u0627\u0633\u0629 \u0630\u0648\u0628\u0627\u0646\u064a\u0629 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0646\u0642\u064a\u0629:<\/strong><\/p>\n<p>\u062a\u0645 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u064a\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062f\u0648\u0631\u0642 \u0627\u0644\u0647\u0632\u0627\u0632, \u062d\u064a\u062b \u062a\u0645 \u0625\u0636\u0627\u0641\u0629 \u0643\u0645\u064a\u0629 \u0641\u0627\u0626\u0636\u0629 \u0645\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u0628\u0639\u062b\u0631\u062a\u0647\u0627 \u0641\u064a 2 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0632\u064a\u0648\u062a \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0633\u0637\u062d\u064a\u0627\u064b \u0648\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0623\u0646\u0627\u0628\u064a\u0628 \u062a\u062b\u0641\u064a\u0644\u060c \u062b\u0645 \u062a\u0645\u0651 \u062a\u0639\u0631\u064a\u0636 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0644\u0644\u0627\u0647\u062a\u0632\u0627\u0632 \u0636\u0645\u0646 \u0627\u0644\u0645\u0627\u0632\u062c (Shaker) \u0644\u0645\u062f\u0629 48 \u0633\u0627\u0639\u0629 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 25\u00b0C \u0644\u0644\u0648\u0635\u0648\u0644 \u0627\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0632\u0646, \u062b\u0641\u0644\u062a \u0628\u0639\u062f\u0647\u0627 \u0628\u0633\u0631\u0639\u0629 6000 \u062f\u0648\u0631\u0629 \u0628\u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0645\u062f\u0629 \u0646\u0635\u0641 \u0633\u0627\u0639\u0629. \u0623\u064f\u062e\u0650\u0630\u064e 1 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0633\u0627\u0626\u0644 \u0627\u0644\u0637\u0627\u0641\u064a \u0648\u0645\u062f\u062f \u0628\u0627\u0644\u0625\u064a\u062b\u0627\u0646\u0648\u0644 96%\u060c \u0648\u062a\u0645\u0651\u062a \u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0628\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0639\u0646\u062f \u0637\u0648\u0644 \u0627\u0644\u0645\u0648\u062c\u0629 232 nm.<\/p>\n<p><strong>\u062a\u062d\u0636\u064a\u0631 \u0627\u0644<\/strong><strong>\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629:<\/strong><\/p>\n<p>\u062a\u0645 \u062a\u062d\u0636\u064a\u0631 6 \u0635\u064a\u063a \u0628\u0623\u0633\u0627\u0633 \u0645\u0646 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a 1% \u0648\u0645\u0632\u064a\u062c \u0645\u0646 \u0645\u0648\u0627\u062f \u0641\u0639\u0627\u0644\u0629 \u0633\u0637\u062d\u064a\u0627\u064b \u0648\u0645\u0648\u0627\u062f \u0645\u0633\u0627\u0639\u062f\u0629 (Smix) \u062a\u0648\u064a\u0646 80 \u0648PEG 400 \u0628\u0646\u0633\u0628 1:3 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a \u0648\u0628\u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u0646 10% \u0627\u0644\u0649.60%<\/p>\n<p>\u062a\u0645 \u0645\u0632\u062c \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0648\u062a\u0648\u064a\u0646 80 \u0648 PEG 400 \u0639\u0644\u0649 \u062d\u0645\u0627\u0645 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629\u060c \u00a0Digital ultrasonic cleaner, Italy)\u060c \u0644\u0645\u062f\u0629 10 \u062f\u0642\u0627\u0626\u0642\u060c \u062b\u0645 \u062a\u0645 \u0625\u0636\u0627\u0641\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0648\u0627\u0644\u062a\u062d\u0631\u064a\u0643 \u0639\u0644\u0649 \u0645\u062d\u0631\u0643 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u062940\u00b0C \u00a0\u062d\u062a\u0649 \u062a\u0645\u0627\u0645 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u060c \u062b\u0645 \u062a\u0645\u0651 \u0627\u0636\u0627\u0641\u0629 \u0627\u0644\u0645\u0627\u0621 \u0642\u0637\u0631\u0629 \u0641\u0642\u0637\u0631\u0629 \u0645\u0639 \u0627\u0644\u062a\u062d\u0631\u064a\u0643 \u0628\u0633\u0631\u0639\u0629 750 \u062f\u0648\u0631\u0629 \u0641\u064a \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0645\u062f\u0629 15 \u062f\u0642\u064a\u0642\u0629\u060c \u062b\u0645\u0651 \u064a\u064f\u0639\u0631\u0651\u0636 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628 \u0644\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0645\u062f\u0629 15 \u062f\u0642\u064a\u0642\u0629 \u0648\u064a\u064f\u062a\u0631\u0643 \u0644\u0644\u062a\u0642\u064a\u064a\u0645 \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062a\u0627\u0644\u064a.<\/p>\n<p><strong>\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629:<\/strong><\/p>\n<p><strong>\u0641\u062d\u0635 \u0627\u0644\u0645\u0638\u0647\u0631 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a<\/strong><strong> :[7] Physical appearance <\/strong><\/p>\n<p>\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0639\u064a\u0627\u0646\u064a\u0627\u064b: \u0627\u0644\u0634\u0641\u0627\u0641\u064a\u0629\u060c \u0627\u0646\u0641\u0635\u0627\u0644 \u0627\u0644\u0623\u0637\u0648\u0627\u0631\u060c \u0627\u0644\u0631\u0648\u0627\u0642\/ \u0627\u0644\u0639\u0643\u0631.<\/p>\n<p><strong>\u0642\u064a\u0627\u0633 \u0646\u0641\u0627\u0630\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 <\/strong><strong>[8] Transmittance<\/strong><strong> %<\/strong><strong>:<\/strong><\/p>\n<p>\u064a\u0639\u062a\u0628\u0631 \u0641\u062d\u0635 \u0646\u0641\u0627\u0630\u064a\u0629 \u0627\u0644\u0636\u0648\u0621 \u0636\u0645\u0646 \u0639\u064a\u0646\u0629 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628 \u0627\u0644\u0645\u0645\u062f\u062f\u0629 \u062e\u0627\u0635\u0629 \u0636\u0648\u0626\u064a\u0629 \u0645\u0645\u064a\u0632\u0629 \u0644\u0647 \u062a\u0634\u064a\u0631 \u0623\u0648 \u062a\u0642\u064a\u0633 \u0639\u0643\u0631 \u0647\u0630\u0627 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u060c \u0645\u0646 \u062e\u0644\u0627\u0644 \u0639\u0644\u0627\u0642\u062a\u0647\u0627 \u0628\u0623\u0628\u0639\u0627\u062f \u0642\u0637\u064a\u0631\u0627\u062a \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0645\u0628\u0639\u062b\u0631. \u062a\u0645 \u0627\u0644\u0642\u064a\u0627\u0633 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a(PG Instruments T80+, UK) \u060c \u062d\u064a\u062b \u0623\u064f\u062e\u0650\u0630\u064e \u00a01\u0645\u0644 \u0645\u0646 \u0643\u0644 \u0639\u064a\u0646\u0629 \u0645\u0633\u062a\u062d\u0644\u0628 \u0648\u0645\u064f\u062f\u062f\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 10 \u0623\u0636\u0639\u0627\u0641\u060c \u062b\u0645 \u0642\u064a\u0633\u062a \u0646\u0641\u0627\u0630\u064a\u062a\u0647 (T%) \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 650 \u0646\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 \u0643\u0646\u0627\u0635\u0639.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2055 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/6-1-300x123.png\" alt=\"\" width=\"539\" height=\"221\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/6-1-300x123.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/6-1-768x315.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/6-1.png 870w\" sizes=\"auto, (max-width: 539px) 100vw, 539px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0641\u062d\u0635<\/strong><strong> \u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 <\/strong><strong>Physical Stability<\/strong> <strong>[9]<\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645\u062a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062b\u0628\u0627\u062a\u064a\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u062b\u0641\u064a\u0644 (HERMLE Z 200A, Germany) \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062b\u0641\u064a\u0644 5\u063a \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0628\u0633\u0631\u0639\u0629 \u00a06000 rpm\u0648\u0644\u0645\u062f\u0629 \u0646\u0635\u0641 \u0633\u0627\u0639\u0629 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 25\u00b0C\u060c \u062a\u0639\u062a\u0628\u0631 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u062b\u0627\u0628\u062a\u0629 \u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0641\u062d\u0635 \u0641\u064a \u062d\u0627\u0644 \u0639\u062f\u0645 \u062d\u062f\u0648\u062b \u0623\u064a \u0641\u0635\u0644 \u0644\u0644\u0623\u0637\u0648\u0627\u0631 \u0623\u0648 \u062a\u0631\u0633\u0628 \u0644\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629.<\/p>\n<p><strong>\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 <\/strong><strong>[10] <\/strong><strong>Drug content<\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645 \u0648\u0632\u0646 \u0643\u0645\u064a\u0651\u0629 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628 \u0645\u0643\u0627\u0641\u0626\u0629 \u0625\u0644\u0649 (5 \u0645\u0644\u063a) \u062f\u0648\u0627\u0621 \u0648\u062d\u0644\u0651\u0647\u0627 \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u064f\u0639\u0627\u064a\u0631 \u0633\u0639\u0629 100 \u0645\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a\u064a + 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644\u060c \u062b\u0645 \u0623\u064f\u062e\u0650\u0630\u064e 1 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0633\u0651\u0627\u0628\u0642 \u0648\u062a\u0645\u0651 \u062a\u0645\u062f\u064a\u062f\u0647 \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u064f\u0639\u0627\u064a\u0631 \u0633\u0639\u0629 10 \u0645\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u062d\u062a\u0649 \u062e\u0637\u0651 \u0627\u0644\u0639\u064a\u0627\u0631\u060c \u0648\u062a\u0645 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0651\u0627\u062a\u062c \u0628\u0639\u062f \u062a\u0631\u0634\u064a\u062d\u0647 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0631\u0634\u062d\u0629 \u0645\u064a\u0643\u0631\u0648\u064a\u0629 (0.22 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631)\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u0651\u064a\u0641 \u0627\u0644\u0636\u0651\u0648\u0626\u064a\u0651 \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0623\u0639\u0638\u0645\u064a 232 nm.<\/p>\n<p><strong>\u0642\u064a\u0627\u0633 <\/strong><strong>\u0644\u0632\u0648\u062c\u0629 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a <\/strong><strong>[10] <\/strong><strong>Viscosity Measurement<\/strong><strong>:<\/strong><\/p>\n<p>\u0623\u064f\u062c\u0631\u064a \u0641\u062d\u0635 \u0627\u0644\u0644\u0632\u0648\u062c\u0629 \u0639\u0644\u0649 \u0639\u064a\u0651\u0646\u0627\u062a \u0628\u062d\u062c\u0645 50 \u0645\u0644 \u0645\u0646 \u0643\u0627\u0641\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629\u060c \u0648\u0630\u0644\u0643 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u0644\u0632\u0648\u062c\u0629 \u062f\u0648\u0631\u0627\u0646\u064a\u0651 FUNGILAB S.A. VISCO ELITE, Spain)) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0628\u0631\u0648\u0643\u0641\u064a\u0644\u062f Brookfield method)) \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 30 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0651\u0629\u060c \u062d\u064a\u062b \u0623\u064f\u062e\u0630\u062a \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u0644\u0635\u064a\u063a \u0645\u0646 \u062d\u064a\u062b \u0646\u0645\u0637 \u0627\u0644\u0645\u063a\u0632\u0644 spindle (\u0646\u0648\u0639 R6) \u0648\u0633\u0631\u0639\u0629 \u0627\u0644\u062f\u0648\u0631\u0627\u0646 100 rpm. \u064a\u064f\u0639\u0628\u0651\u0631 \u0639\u0646 \u0642\u064a\u0645\u0629 \u0627\u0644\u0644\u0632\u0648\u062c\u0629 \u0628\u0648\u0627\u062d\u062f\u0629 \u0627\u0644\u0633\u0646\u062a\u064a\u0628\u0648\u0627\u0632 cP.<\/p>\n<p><strong>\u0642\u064a\u0627\u0633 \u062f\u0631\u062c\u0629 \u0627\u0644\u0628\u0627\u0647\u0627\u0621 <\/strong><strong>[11] pH<\/strong><strong> Measurement<\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0642\u064a\u0627\u0633 \u0642\u064a\u0645\u0629 \u0628\u0627\u0647\u0627\u0621 \u0627\u0644\u0648\u0633\u0637 (Hanna Instruments pH 211, Italy), \u062d\u064a\u062b \u062a\u0645\u0651 \u0623\u062e\u0630 \u00a01\u0645\u0644 \u0645\u0646 \u0643\u0644 \u0639\u064a\u0646\u0629 \u0645\u0633\u062a\u062d\u0644\u0628 \u0648\u0645\u064f\u062f\u0651\u0650\u062f\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 10 \u0623\u0636\u0639\u0627\u0641\u060c \u062b\u0645 \u0642\u064a\u0627\u0633 \u062f\u0631\u062c\u0629 \u0627\u0644 pH \u0644\u0647.<\/p>\n<p><strong>\u0642\u064a\u0627\u0633 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 <\/strong><strong>Conductivity Measurement<\/strong> <strong>[12]<\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645 \u0642\u064a\u0627\u0633 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 \u0644\u0644\u0640\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629<br \/>\n(APERA INSTRUMENTS, EC700 Conductivity Meter)\u060c \u0627\u0644\u0645\u0639\u0627\u064a\u0631 \u0628\u0645\u062d\u0644\u0648\u0644 \u0642\u064a\u0627\u0633\u064a \u0645\u0646 KCl. \u062a\u0645 \u063a\u0633\u0644 \u0627\u0644\u0642\u0637\u0628 \u0642\u0628\u0644 \u0643\u0644 \u0642\u064a\u0627\u0633 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 \u0645\u0631\u0629 \u062b\u0645 \u0627\u0644\u063a\u0633\u0644 \u0628\u0627\u0644\u0639\u064a\u0646\u0629 \u0645\u0631\u062a\u064a\u0646\u060c \u064a\u064f\u0639\u0628\u0651\u0631 \u0639\u0646 \u0642\u064a\u0645\u0629 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629 \u0628\u0648\u0627\u062d\u062f\u0629 (\u00b5S\/cm).<\/p>\n<p><strong>\u0642\u0631\u064a\u0646\u0629 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631 <\/strong><strong>Refractive Index<\/strong> <strong>[13]<\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645 \u062a\u062d\u062f\u064a\u062f \u0642\u0631\u064a\u0646\u0629 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631 \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 25 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631 (CARL ZEISS JENA) \u0648\u0630\u0644\u0643 \u0628\u0648\u0636\u0639 \u0642\u0637\u0631\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0634\u0631\u064a\u062d\u0629\u060c \u062a\u0645 \u0645\u0639\u0627\u064a\u0631\u0629 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0642\u0631\u064a\u0646\u0629 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631 \u0644\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631.<\/p>\n<p><strong>\u0642\u064a\u0627\u0633 \u0645\u062a\u0648\u0633\u0637 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0648\u0645\u064e\u0646\u0633\u064e\u0628 \u0627\u0644\u062a\u0634\u062a\u0651\u064f\u062a \u0627\u0644\u0645\u062a\u0639\u062f\u062f <\/strong><strong>(PDI)<\/strong> <strong>:[14]<\/strong><\/p>\n<p>\u0642\u064a\u0633 \u0645\u062a\u0648\u0633\u0637 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a (Droplet Size) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 \u062a\u0634\u062a\u062a \u0627\u0644\u0636\u0648\u0621 \u0627\u0644\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u064a Dynamic Light Scattering DLS \u0636\u0645\u0646 \u062c\u0647\u0627\u0632 (Nanosizer, Malvern, UK) \u0644\u062a\u0642\u064a\u064a\u0645 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u0642\u0637\u064a\u0631\u0627\u062a\u060c \u0648\u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0629 \u0648\u0645\u062f\u0649 \u062a\u062c\u0627\u0646\u0633 \u062a\u0648\u0632\u0639\u0647\u0627 \u0628\u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u0645\u064e\u0646\u0633\u064e\u0628 \u0627\u0644\u062a\u0634\u062a\u0651\u064f\u062a \u0627\u0644\u0645\u062a\u0639\u062f\u062f Polydispersity Index (PDI)\u060c \u0648\u0627\u0644\u0630\u064a \u0643\u0644\u0645\u0627 \u0635\u064e\u063a\u064f\u0631\u062a \u0642\u064a\u0645\u062a\u0647 \u0648\u0643\u0627\u0646\u062a \u0623\u0642\u0644 \u0645\u0646 .50 \u0643\u0627\u0646 \u0645\u062c\u0627\u0644 \u062a\u0648\u0632\u0639 \u0647\u0630\u0647 \u0627\u0644\u0623\u0628\u0639\u0627\u062f \u0636\u064a\u0642 \u0623\u064a \u0639\u064a\u0646\u0629 \u0645\u062a\u062c\u0627\u0646\u0633\u0629. \u062a\u0645\u0651 \u0627\u0644\u0641\u062d\u0635 \u0628\u0623\u062e\u0630 (1 \u0645\u0644) \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0648\u062a\u0645\u062f\u064a\u062f\u0647\u0627 \u0628\u0627\u0644\u0645\u0627\u0621 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u062a\u0642\u0637\u064a\u0631 50 \u0636\u0639\u0641.<\/p>\n<p><strong>\u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0645\u0627\u0633\u062d<\/strong><strong>:[15] Scanning Electron Microscopy (SEM) <\/strong><\/p>\n<p>\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062c\u0647\u0631 \u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0645\u0627\u0633\u062d (TESCAN, VEGA, Czech Republic) \u0644\u0641\u062d\u0635 \u0634\u0643\u0644 \u0648\u062e\u0648\u0627\u0635 \u0633\u0637\u062d \u0648\u062d\u062c\u0645 \u0642\u0637\u064a\u0631\u0627\u062a \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u062f\u0627\u062e\u0644\u064a\u060c \u0645\u064f\u062f\u0651\u0650\u062f\u064e\u062a \u0627\u0644\u0639\u064a\u0646\u0629 \u0639\u0634\u0631 \u0645\u0631\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0645\u0642\u0637\u0631 \u0628\u062f\u0648\u0646 \u0623\u064a \u0637\u0644\u064a.<\/p>\n<p><strong>\u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0643\u064a\u0627\u0633 \u0627\u0644\u062a\u062d\u0627\u0644<\/strong><strong>[10] <\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645\u0651 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0643\u064a\u0627\u0633 \u0627\u0644\u062a\u062d\u0627\u0644 Aldon Corporation, USA)) \u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u063a\u0634\u0627\u0621 \u0646\u0635\u0641 \u0646\u0641\u0648\u0630 \u0645\u0646 \u0623\u0633\u064a\u062a\u0627\u062a \u0627\u0644\u0633\u064a\u0644\u0644\u0648\u0632\u060c \u0630\u0627\u062a (MWCO 12-14 KDa) \u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c:<\/p>\n<p>\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u0639\u0645\u0644:<\/p>\n<p>\u0623\u064f\u062e\u0650\u0630\u064e 1 \u0645\u0644 \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0645\u062d\u0636\u0631\u0629\u060c \u0648\u0648\u0636\u0639\u062a \u0636\u0645\u0646 \u0643\u064a\u0633 \u0627\u0644\u062a\u062d\u0627\u0644 \u0627\u0644\u0645\u0631\u0637\u0628 \u0645\u0633\u0628\u0642\u0627\u064f \u0639\u0646 \u0637\u0631\u064a\u0642 \u0646\u0642\u0639\u0647 \u0636\u0645\u0646 \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a (pH 6.4) \u0644\u0645\u062f\u0629 24 \u0633\u0627\u0639\u0629.<\/p>\n<p>\u0648\u0636\u0639 \u0643\u064a\u0633 \u0627\u0644\u062a\u062d\u0627\u0644\u060c \u0628\u0639\u062f \u0627\u063a\u0644\u0627\u0642\u0647\u060c \u0636\u0645\u0646 200 \u0645\u0644 \u0645\u0646 \u0645\u0632\u064a\u062c \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a (pH 6.4) + 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644 96% \u0636\u0645\u0646 \u0628\u064a\u0634\u0631 \u0632\u062c\u0627\u062c\u064a \u0648\u0627\u0644\u062a\u062d\u0631\u064a\u0643 \u0628\u0633\u0631\u0639\u0629 200 rpm \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 1\u00b134 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062d\u0645\u0627\u0645 \u0645\u0627\u0626\u064a \u0648\u0645\u062d\u0631\u0643 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a China) , (DLAB MS7-H550\u060c \u0648\u0633\u062d\u0628 5 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0628\u064a\u0634\u0631 \u0627\u0644\u0632\u062c\u0627\u062c\u064a \u0628\u0641\u0648\u0627\u0635\u0644 \u0632\u0645\u0646\u064a\u0629 \u0645\u062d\u062f\u062f\u0629 (0.5,1,2,3,4,5,6,7,8,24 \u0633\u0627\u0639\u0629)\u060c \u0645\u0639 \u0645\u0631\u0627\u0639\u0627\u0629 \u062a\u0639\u0648\u064a\u0636 \u0627\u0644\u062d\u062c\u0645 \u0627\u0644\u0645\u0633\u062d\u0648\u0628 \u0645\u0628\u0627\u0634\u0631\u0629 \u0628\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0641\u064a \u0643\u0644 \u0645\u0631\u0629 \u0644\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u0634\u0631\u0637 \u0627\u0644\u0625\u063a\u0631\u0627\u0642 (Sink Condition).<\/p>\n<p>\u062d\u064f\u062f\u0651\u0650\u062f\u064e\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0642\u064a\u0627\u0633 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 232 nm \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a\u060c \u0645\u0642\u0627\u0628\u0644 \u0645\u0632\u064a\u062c \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a (pH 6.4) + 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644 96% \u0643\u0634\u0627\u0647\u062f.<\/p>\n<p><strong>\u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629:<\/strong><\/p>\n<p>\u062a\u0645\u064e\u0651 \u0627\u0639\u062a\u0645\u0627\u062f \u0627\u062e\u062a\u0628\u0627\u0631 (One-way Anova) \u0644\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629\u060c \u0648\u0627\u0639\u062a\u064f\u0628\u0631\u062a \u0627\u0644\u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u0623\u0647\u0645\u064a\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062f\u0644\u0627\u0644\u0629 (P &lt; 0.05).<\/p>\n<p><strong>\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 <\/strong><strong>Drug \u2013 excipient interactions<\/strong><strong>:<\/strong><\/p>\n<p><strong>\u00a0<\/strong><strong>\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a <\/strong><strong>Differential Scanning Calorimetry<\/strong> <strong>[16]<\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645 \u0627\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 (SETARAM DSC 131,France)\u060c \u062d\u064a\u062b \u062a\u0645 \u0648\u0632\u0646 \u0639\u064a\u0646\u0627\u062a (4-5 \u0645\u064a\u0644\u064a \u063a\u0631\u0627\u0645) \u0628\u0634\u0643\u0644 \u062f\u0642\u064a\u0642\u060c \u0645\u0639 \u0648\u0636\u0639\u0647\u0627 \u0636\u0645\u0646 \u0628\u0648\u062a\u0642\u0629 \u062e\u0627\u0635\u0629 \u0645\u0646 \u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645\u060c \u0648\u062a\u0645\u0651 \u0627\u062d\u0643\u0627\u0645 \u0627\u063a\u0644\u0627\u0642\u0647\u0627 \u062c\u064a\u062f\u0627 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0643\u0628\u0633 \u062e\u0627\u0635. \u0623\u062c\u0631\u064a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0648\u062a\u0642\u0629 \u062b\u0627\u0646\u064a\u0629 \u0641\u0627\u0631\u063a\u0629 \u0645\u0646 \u0627\u0644\u0627\u0644\u0645\u0646\u064a\u0648\u0645 \u0643\u0634\u0627\u0647\u062f\u060c \u0648\u0630\u0644\u0643 \u0628\u062a\u0639\u0631\u064a\u0636 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0625\u0644\u0649 \u062d\u0631\u0627\u0631\u0629 \u0628\u0645\u0639\u062f\u0644 \u0645\u062a\u0632\u0627\u064a\u062f 10\u00b0C\/min. \u062a\u0645 \u0627\u062c\u0631\u0627\u0621 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062d\u0648\u0642 \u0627\u0644\u0646\u0642\u064a\u0651 \u0644\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a\u060c \u0645\u0646 \u062b\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0645\u0639 \u0643\u0644 \u0633\u0648\u0627\u063a \u0648\u0630\u0644\u0643 \u0628\u0646\u0633\u0628 (1:1).<\/p>\n<p><strong>\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 <\/strong><strong>FTIR Spectroscopy<\/strong> <strong>[17]<\/strong><strong>:<\/strong><\/p>\n<p>\u062a\u0645 \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0627\u0644\u0645\u0633\u062d \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 (Bruker IR-10049361 FTIR, Germany)\u060c \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u0645\u0646 \u062b\u0645\u0651 \u0639\u0644\u0649 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0645\u0639 \u0643\u0644 \u0633\u0648\u0627\u063a \u0645\u064f\u0633\u062a\u062e\u062f\u064e\u0645\u060c \u0628\u0646\u0633\u0628 (1:1)\u060c \u0648\u0630\u0644\u0643 \u0628\u0647\u062f\u0641 \u0627\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062d\u062f\u0648\u062b \u0623\u064a \u062a\u0622\u062b\u0631 \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u063a.<\/p>\n<p><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Results and Discussion<\/strong><\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c <\/strong><strong>\u062f\u0631\u0627\u0633\u0629 \u0630\u0648\u0628\u0627\u0646\u064a\u0629 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0646\u0642\u064a\u0629<\/strong><strong>:<\/strong><\/p>\n<p>\u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (2) \u0642\u064a\u0645 \u0630\u0648\u0628\u0627\u0646\u064a\u0629 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0632\u064a\u0648\u062a \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0633\u0637\u062d\u064a\u0627\u064b \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629.<\/p>\n<p>\u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u062a\u064a \u0623\u0628\u062f\u062a \u0642\u062f\u0631\u0629 \u0623\u0643\u0628\u0631 \u0639\u0644\u0649 \u062d\u0644 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 (\u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a\u060c \u0628\u0648\u0644\u064a \u0625\u064a\u062b\u064a\u0644\u064a\u0646 \u063a\u0644\u064a\u0643\u0648\u0644 400\u060c \u0627\u0644\u062a\u0648\u064a\u0646 80).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2056 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/7-1-233x300.png\" alt=\"\" width=\"287\" height=\"370\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/7-1-233x300.png 233w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/7-1.png 417w\" sizes=\"auto, (max-width: 287px) 100vw, 287px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629:<\/strong><\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0627\u0644\u0645\u0638\u0647\u0631<\/strong><strong> \u0648\u0627\u0644\u062b\u0628\u0627\u062a<\/strong> <strong>\u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a<\/strong><strong>:<\/strong><\/p>\n<p>\u064a\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (3) \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0627\u0644\u0645\u0638\u0647\u0631 \u0648\u0627\u0644\u062b\u0628\u0627\u062a \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a, \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0635\u064a\u063a\u0629 F1 \u0639\u0643\u0631\u0629 \u0628\u0644\u0648\u0646 \u062d\u0644\u064a\u0628\u064a \u0623\u0645\u0627 \u0628\u0627\u0642\u064a \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0643\u0627\u0646\u062a: \u0634\u0641\u0627\u0641\u0629 \u0648\u0628\u0644\u0648\u0646 \u0623\u0635\u0641\u0631. \u064a\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 (1) \u0645\u0638\u0647\u0631 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u062a\u064a \u062d\u0642\u0642\u062a \u0627\u0644\u062b\u0628\u0627\u062a \u0648\u0627\u0644\u0645\u0638\u0647\u0631 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2057 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/8-1-256x300.png\" alt=\"\" width=\"303\" height=\"355\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/8-1-256x300.png 256w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/8-1.png 436w\" sizes=\"auto, (max-width: 303px) 100vw, 303px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2058 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/9-282x300.png\" alt=\"\" width=\"346\" height=\"368\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/9-282x300.png 282w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/9.png 438w\" sizes=\"auto, (max-width: 346px) 100vw, 346px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0646\u0641\u0627\u0630\u064a\u0629 \u0627\u0644\u0636\u0648\u0626\u064a\u0629 \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a <\/strong><strong>T%<\/strong><strong>:<\/strong><\/p>\n<p>\u064a\u0628\u064a\u0646\u00a0\u0627\u0644\u062c\u062f\u0648\u0644 (4) \u0642\u064a\u0645 \u0646\u0641\u0627\u0630\u064a\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629\u060c \u062d\u064a\u062b \u062a\u0631\u0627\u0648\u062d\u062a \u0642\u064a\u0645 \u0627\u0644\u0646\u0641\u0627\u0630\u064a\u0629\u00a0\u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u064a\u0646 %98.33 \u0625\u0644\u0649 99.38%\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0623\u0639\u0644\u0627\u0647\u0627 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 F4. \u0645\u0645\u0627 \u0642\u062f \u064a\u062f\u0644 \u0639\u0644\u0649 \u0635\u063a\u0631 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u062f\u0627\u062e\u0644\u064a.<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629:<\/strong><\/p>\n<p>\u064a\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (4) \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0641\u0639\u0644\u064a \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0636\u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0623\u062e\u0648\u0630\u0629 \u0645\u0646 \u0643\u0644 \u0635\u064a\u063a\u0629 \u0645\u062d\u0636\u0631\u0629 \u0628\u062b\u0644\u0627\u062b \u062a\u0643\u0631\u0627\u0631\u0627\u062a. \u062a\u0631\u0627\u0648\u062d\u062a \u0646\u062a\u0627\u0626\u062c \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u064a\u0646 %93.0 \u0648%105.9 \u0648\u0630\u0644\u0643 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0645\u062a\u0637\u0644\u0651\u0628\u0627\u062a \u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a USP 44 [18].<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0644\u0632\u0648\u062c\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629:<\/strong><\/p>\n<p>\u062a\u0631\u0627\u0648\u062d\u062a \u0642\u064a\u0645 \u0627\u0644\u0644\u0632\u0648\u062c\u0629 \u0628\u064a\u0646 11.4 cP \u0648410.3 cP. (\u0627\u0644\u062c\u062f\u0648\u0644 4) \u0625\u0630 \u062a\u0628\u064a\u0646 \u0623\u0646\u0651 \u0632\u064a\u0627\u062f\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u0632\u064a\u062c \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u0637\u062d \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0644\u0632\u0648\u062c\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629\u060c \u0642\u062f \u064a\u0643\u0648\u0646 \u0627\u0644\u0633\u0628\u0628 \u0647\u0648 \u0623\u0646 \u0627\u0644\u0633\u0644\u0627\u0633\u0644 \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621 \u0644\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644 \u0639\u0644\u0649 \u0627\u0644\u0633\u0637\u062d \u063a\u064a\u0631 \u0627\u0644\u0623\u064a\u0648\u0646\u064a (\u062a\u0648\u064a\u0646 80) \u0648\u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f (PEG 400) \u062a\u062a\u0645\u064a\u0647 \u0628\u0634\u062f\u0651\u0629 \u0648\u062a\u0631\u062a\u0628\u0637 \u0628\u0628\u0639\u0636\u0647\u0627 \u0627\u0644\u0628\u0639\u0636 \u0628\u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0628\u062a\u062f\u0627\u062e\u0644 \u0642\u0648\u064a[19] .<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0642\u064a\u0645 \u0628\u0627\u0647\u0627\u0621 <\/strong><strong>pH<\/strong><strong> \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a:<\/strong><\/p>\n<p>\u062a\u0631\u0627\u0648\u062d \u0645\u062c\u0627\u0644 \u0627\u0644\u0642\u064a\u0645 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629 \u0645\u0627 \u0628\u064a\u0646 5.2 \u06485.7\u060c (\u0627\u0644\u062c\u062f\u0648\u0644 4)\u060c \u0648\u0647\u0630\u0627 \u064a\u0639\u0646\u064a \u0623\u0646\u0651 \u0627\u0644\u0635\u064a\u063a \u0636\u0645\u0646 \u0645\u062c\u0627\u0644 \u0627\u0644\u0628\u0627\u0647\u0627\u0621 pH \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a \u0627\u0644\u0645\u0642\u0628\u0648\u0644 6.5) -4.5) \u0648\u0627\u0644\u0630\u064a \u0644\u0627 \u064a\u064f\u0633\u0628\u0651\u0628 \u062a\u062e\u0631\u064a\u0634\u0627\u064b \u0644\u0644\u0623\u0646\u0641\u060c \u0630\u0644\u0643 \u0623\u0646 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u062d\u0645\u0636 \u0636\u0639\u064a\u0641\u060c \u0648\u0628\u0642\u064a\u0651\u0629 \u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u064a\u063a \u063a\u064a\u0631 \u0645\u062a\u0623\u064a\u0651\u0646\u0629 \u00a0.[20]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2059 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/10-300x109.png\" alt=\"\" width=\"520\" height=\"189\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/10-300x109.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/10-768x278.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/10.png 875w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0642\u064a\u0627\u0633 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 \u0648\u0642\u0631\u064a\u0646\u0629 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631:<\/strong><\/p>\n<p>\u062a\u0631\u0627\u0648\u062d \u0645\u062c\u0627\u0644 \u0642\u064a\u0645 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629 \u0645\u0627 \u0628\u064a\u0646 65.6 \u0648161.8 \u0645\u064a\u0643\u0631\u0648\u0633\u064a\u0645\u0646\u0633\/\u0633\u0645 \u0623\u064a \u0623\u0646 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0632\u062f\u0627\u062f\u062a \u0628\u0632\u064a\u0627\u062f\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0634\u0648\u0627\u0631\u062f \u0641\u064a \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0645\u0627\u0626\u064a.<\/p>\n<p>\u0648\u0642\u062f \u0648\u0631\u062f \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0623\u0646 \u0627\u0644\u0646\u0627\u0642\u0644\u064a\u0629 \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0646 \u0646\u0645\u0637 \u0627\u0644\u0645\u0627\u0621 \u0641\u064a \u0627\u0644\u0632\u064a\u062a (w\/o) \u062a\u0643\u0648\u0646 \u0639\u0627\u062f\u0629 \u0623\u0642\u0644 \u0645\u0646 (\u00b5S\/cm) 10\u060c \u0628\u064a\u0646\u0645\u0627 \u062a\u062a\u0645\u062a\u0639 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0645\u0646 \u0646\u0645\u0637 \u0627\u0644\u0632\u064a\u062a \u0641\u064a \u0627\u0644\u0645\u0627\u0621 (o\/w) \u0628\u0646\u0627\u0642\u0644\u064a\u0629 \u0623\u0639\u0644\u0649\u060c \u062a\u0632\u064a\u062f \u0639\u0646 (\u00b5S\/cm)10 \u00a0.[19]<\/p>\n<p>\u0623\u0645\u0627 \u0645\u062c\u0627\u0644 \u0642\u064a\u0645 \u0642\u0631\u0627\u0626\u0646 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631 \u0644\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 1.366 \u06481.426\u060c \u0648\u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0642\u064a\u0645 \u0642\u0631\u0627\u0626\u0646 \u0627\u0646\u0643\u0633\u0627\u0631 \u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0635\u064a\u063a:<\/p>\n<p>\u0627\u0644\u0645\u0627\u0621: 1.328\u060c \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a: 1.467\u060c \u0627\u0644\u062a\u0648\u064a\u0646 80: 1.475\u060c :PEG 400 1.469.<\/p>\n<p>\u062a\u0628\u064a\u0646 \u0623\u0646 \u0627\u0632\u062f\u064a\u0627\u062f \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u062a\u0648\u064a\u0646 80 \u0648\u0628\u0648\u0644\u064a \u0627\u064a\u062b\u064a\u0644\u064a\u0646 \u063a\u0644\u064a\u0643\u0648\u0644 \u0633\u0628\u0628 \u0632\u064a\u0627\u062f\u0629 \u0642\u0631\u0627\u0626\u0646 \u0627\u0646\u0643\u0633\u0627\u0631 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a\u060c \u0648\u0630\u0644\u0643 \u0644\u0623\u0646 \u0643\u0644 \u0645\u0646\u0647\u0645\u0627 \u0644\u0647 \u0637\u0628\u064a\u0639\u0629 \u0645\u062d\u0628\u0629 \u0644\u0644\u0645\u0627\u0621\u060c \u0644\u0623\u0646\u0651 \u0639\u0646\u062f \u0645\u0632\u062c \u0627\u0644\u062a\u0648\u064a\u0646 80 \u0630\u0648 \u0627\u0644\u0643\u062b\u0627\u0641\u0629 (1.08 g\/cm<sup>3<\/sup>) \u0648\u0627\u0644\u0640 PEG 400 \u0630\u0648 \u0627\u0644\u0643\u062b\u0627\u0641\u0629 (1.12 g\/cm<sup>3<\/sup>) \u0645\u0639 \u0627\u0644\u0645\u0627\u0621 \u062a\u0632\u062f\u0627\u062f \u0627\u0644\u0643\u062b\u0627\u0641\u0629 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0632\u062f\u0627\u062f \u0642\u0631\u064a\u0646\u0629 \u0627\u0644\u0627\u0646\u0643\u0633\u0627\u0631.<\/p>\n<p><strong>\u062f\u0631\u0627\u0633\u0629 \u0623\u0628\u0639\u0627\u062f \u0642\u0637\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0628\u0640\u0627\u0644\u0640 <\/strong><strong>Nanosizer<\/strong><strong>:<\/strong><\/p>\n<p>\u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (5) \u0646\u062a\u0627\u0626\u062c \u0645\u062a\u0648\u0633\u0637 \u0623\u0628\u0639\u0627\u062f \u0642\u0637\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0640 Nanosizer.<\/p>\n<p>\u0627\u0639\u062a\u0645\u062f \u0645\u062a\u0648\u0633\u0637 \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u0642\u0637\u064a\u0631\u0627\u062a \u0639\u0644\u0649 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0640 Smix\u060c \u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0628\u0639\u0627\u062f \u0642\u0637\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0628\u0623\u0633\u0627\u0633 \u0645\u0646 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0628\u064a\u0646 13 \u0648204 \u0646\u0627\u0646\u0648\u0645\u062a\u0631.<\/p>\n<p>\u0627\u0646\u062e\u0641\u0636\u062a \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u0642\u0637\u064a\u0631\u0627\u062a \u0628\u0627\u0632\u062f\u064a\u0627\u062f \u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u0632\u064a\u062c \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644 \u0639\u0644\u0649 \u0627\u0644\u0633\u0637\u062d \u0648\u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f (Smix) \u0628\u0641\u0627\u0631\u0642 \u064a\u0639\u062a\u062f \u0628\u0647 \u0627\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P value &lt; 0.05).<\/p>\n<p>\u0648\u0647\u0648 \u0645\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 Ramreddy \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0639\u0627\u0645 2018 \u062d\u064a\u062b \u0642\u0627\u0645\u0648\u0627 \u0628\u062a\u062d\u0636\u064a\u0631 \u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0646 \u0627\u0644\u062f\u064a\u0627\u0632\u064a\u0628\u0627\u0645 \u0644\u0644\u0625\u064a\u062a\u0627\u0621 \u0627\u0644\u0623\u0646\u0641\u064a[16] .<\/p>\n<p>\u0643\u0627\u0646\u062a \u0642\u064a\u0645 \u0627\u0644\u0640 PDI \u0623\u0642\u0644 \u0645\u0646 0.5 \u0644\u062c\u0645\u064a\u0639 \u0635\u064a\u063a \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u0642\u0627\u0631\u0628 \u062d\u062c\u0645 \u0627\u0644\u0642\u0637\u064a\u0631\u0627\u062a \u0648\u062a\u062c\u0627\u0646\u0633\u0647\u0627.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2060 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/11-300x294.png\" alt=\"\" width=\"361\" height=\"354\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/11-300x294.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/11.png 442w\" sizes=\"auto, (max-width: 361px) 100vw, 361px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0645\u0627\u0633<\/strong><strong>\u062d<\/strong><strong> :(SEM) <\/strong><\/p>\n<p>\u064a\u064f\u0638\u0647\u0650\u0631 \u0627\u0644\u0634\u0643\u0644 (2) \u0635\u0648\u0631 \u0627\u0644 SEM \u0644\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u062d\u064a\u062b \u062a\u0638\u0647\u0631 \u0627\u0644\u0642\u0637\u064a\u0631\u0627\u062a \u0628\u0623\u0634\u0643\u0627\u0644 \u0643\u0631\u0648\u064a\u0651\u0629.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2061 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/12-179x300.png\" alt=\"\" width=\"300\" height=\"503\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/12-179x300.png 179w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/12.png 398w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c:<\/strong><\/p>\n<p>\u0627\u0645\u062a\u062f\u0651 \u062a\u062d\u0631\u0631 \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0625\u0644\u0649 24 \u0633\u0627\u0639\u0629 \u0645\u0627\u0639\u062f\u0627 \u0627\u0644\u0635\u064a\u063a\u0629 F6\u060c \u062d\u064a\u062b \u062d\u0631\u0631\u062a 97% \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u062e\u0644\u0627\u0644 8 \u0633\u0627\u0639\u0627\u062a \u0623\u0645\u0627 \u0628\u0627\u0642\u064a \u0627\u0644\u0635\u064a\u063a \u0641\u0623\u0639\u0637\u062a \u062a\u062d\u0631\u0631\u0627\u064b \u0628\u064a\u0646 23% \u064838% \u062e\u0644\u0627\u0644 8 \u0633\u0627\u0639\u0627\u062a \u0648\u062a\u062d\u0631\u0631\u0627\u064b \u0628\u064a\u0646 62% \u064898% \u062e\u0644\u0627\u0644 24 \u0633\u0627\u0639\u0629.<\/p>\n<p>\u0648\u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 (One-way Anova) \u0639\u0644\u0649 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u0634\u062a\u0631\u0643\u0629 \u0628\u0646\u0648\u0639 \u0627\u0644\u0632\u064a\u062a \u0648\u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0628\u0646\u0633\u0628\u0629 Smix \u062a\u0628\u064a\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u062c\u0648\u0647\u0631\u064a ,(P&lt;0.05, n=3) \u0641\u064a \u0627\u0644\u062a\u062d\u0631\u0631 \u0628\u064a\u0646 \u0627\u0644\u0635\u064a\u063a \u0648\u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0646\u0642\u064a\u0629 \u0639\u0646\u062f \u0627\u0644\u0640 24 \u0633\u0627\u0639\u0629\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 P-Value = 0.0075. \u0645\u0645\u0627 \u064a\u0628\u064a\u0646 \u0623\u062b\u0631 \u0632\u064a\u0627\u062f\u0629 \u0646\u0633\u0628\u0629 Smix \u0641\u064a \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u062a\u062d\u0631\u0631\u060c \u062d\u064a\u062b \u0627\u0632\u062f\u0627\u062f \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0628\u0627\u0632\u062f\u064a\u0627\u062f \u062a\u0631\u0643\u064a\u0632 \u0645\u0632\u064a\u062c \u0627\u0644\u062a\u0648\u064a\u0646 80 \u0648PEG 400\u060c \u0648\u0647\u0648 \u0645\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0642\u0627\u0645 \u0628\u0647\u0627 Jain \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0639\u0627\u0645 2023 \u062d\u064a\u062b \u0642\u0627\u0645\u0648\u0627 \u0628\u062a\u062d\u0636\u064a\u0631 \u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0646 \u0627\u0644\u0643\u064a\u062a\u0648\u0643\u0648\u0646\u0627\u0632\u0648\u0644\u060c \u0648\u062c\u062f\u0648\u0627 \u0623\u0646\u0651 \u0632\u064a\u0627\u062f\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0640 Smix \u0633\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0639\u0632\u064a\u0632 \u0627\u0646\u062d\u0644\u0627\u0644\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a \u0648\u0623\u0628\u0639\u0627\u062f \u0642\u0637\u064a\u0631\u0627\u062a \u0623\u0635\u063a\u0631 \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0645\u0633\u0627\u062d\u0629 \u0627\u0644\u0633\u0637\u062d \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0627\u0632\u062f\u064a\u0627\u062f \u0645\u0639\u062f\u0644 \u0627\u0644\u062a\u062d\u0631\u0631 .[21]<\/p>\n<p>\u064a\u0628\u064a\u0646 \u0627\u0644\u0634\u0643\u0644 (3) \u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 (Q%) \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0632\u0645\u0646 (T) \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0646\u0642\u064a \u062e\u0644\u0627\u0644 24 \u0633\u0627\u0639\u0629.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2062 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/13-300x241.png\" alt=\"\" width=\"395\" height=\"317\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/13-300x241.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/13.png 450w\" sizes=\"auto, (max-width: 395px) 100vw, 395px\" \/><\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629:<\/strong><\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a <\/strong><strong>DSC<\/strong><strong>:<\/strong><\/p>\n<p>\u0641\u064a \u0645\u062e\u0637\u0637 \u0627\u0644\u0640 DSC \u0644\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0646\u0642\u064a (\u0627\u0644\u0634\u0643\u0644 4) \u064a\u064f\u0644\u0627\u062d\u064e\u0638:<\/p>\n<p>\u0642\u0645\u0629 \u062d\u0627\u062f\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 185 \u0645\u0626\u0648\u064a\u0629\u060c \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u0647\u064a \u0642\u0645\u0629 \u062d\u0627\u062f\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0628\u0644\u0648\u0631\u064a\u0629 \u0648\u0646\u0642\u0627\u0648\u062a\u0647 .[22]<\/p>\n<p>\u0642\u062f \u062a\u0634\u064a\u0631 \u0627\u0644\u0642\u0645\u0629 \u0627\u0644\u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 389 \u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0649 \u0627\u0646\u0641\u0635\u0627\u0644 \u062d\u0644\u0642\u0629 \u0627\u0644\u0628\u0628\u0631\u0627\u0632\u064a\u0646 \u0639\u0646 \u062d\u0644\u0642\u0629 \u0627\u0644\u0628\u0646\u0632\u0648\u062f\u064a\u0627\u0632\u0628\u064a\u0646 \u0627\u0644\u0633\u0628\u0627\u0639\u064a\u0629\u060c \u0627\u0645\u0627 \u0627\u0644\u0642\u0645\u062a\u064a\u0646 \u0627\u0644\u0646\u0627\u0634\u0631\u062a\u064a\u0646 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u062a\u064a \u0627\u0644\u062d\u0631\u0627\u0631\u0629 384\u060c395 \u0642\u062f \u062a\u0634\u064a\u0631\u0627\u0646 \u0627\u0644\u0649 \u062a\u0641\u0643\u0643 \u0627\u0644\u0645\u062c\u0648\u0639\u0627\u062a \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0648\u062a\u062e\u0631\u0628 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2063 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/14-300x233.png\" alt=\"\" width=\"366\" height=\"284\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/14-300x233.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/14.png 447w\" sizes=\"auto, (max-width: 366px) 100vw, 366px\" \/><\/p>\n<p>\u0641\u064a \u0645\u062e\u0637\u0637 \u0627\u0644\u0640 DSC \u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a (\u0627\u0644\u0634\u0643\u0644 5):<\/p>\n<p>\u063a\u0627\u0628\u062a \u0642\u0645\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0627\u0646\u062d\u0644\u0627\u0644\u0647 \u0628\u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a\u060c \u0627\u0644\u0642\u0645\u062a\u064a\u0646 \u0627\u0644\u0645\u0627\u0635\u062a\u064a\u0646 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u062a\u064a \u0627\u0644\u062d\u0631\u0627\u0631\u0629 332\u060c278 \u062a\u0634\u064a\u0631\u0627\u0646 \u0627\u0644\u0649 \u062f\u0631\u062c\u0629 \u063a\u0644\u064a\u0627\u0646 \u0648\u062a\u062e\u0631\u0628 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062a\u064a\u0628.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2064 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/15-300x259.png\" alt=\"\" width=\"336\" height=\"290\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/15-300x259.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/15.png 437w\" sizes=\"auto, (max-width: 336px) 100vw, 336px\" \/><\/p>\n<p>\u0641\u064a \u0645\u062e\u0637\u0637 \u0627\u0644\u0640 DSC \u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u0627\u0644\u062a\u0648\u064a\u0646 80 (\u0627\u0644\u0634\u0643\u0644 6):<\/p>\n<p>\u0647\u0646\u0627\u0643 \u0627\u0646\u0632\u064a\u0627\u062d \u0641\u064a \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0625\u0644\u0649 \u0627\u0644\u062f\u0631\u062c\u0629 \u00b0C168\u060c \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u0634\u062f\u0629 \u0627\u0644\u0642\u0645\u0629 \u0645\u0645\u0627 \u0642\u062f \u064a\u062f\u0644 \u0639\u0644\u0649 \u0627\u0646\u062d\u0644\u0627\u0644 \u062c\u0632\u0626\u064a \u0644\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u062a\u0648\u064a\u0646 80\u060c \u0623\u064a\u0636\u0627\u064b \u0642\u0645\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 354 \u0642\u062f \u062a\u0634\u064a\u0631 \u0627\u0644\u0649 \u062a\u062e\u0631\u0628 \u0627\u0644\u062a\u0648\u064a\u0646 80.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2065 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/16-300x253.png\" alt=\"\" width=\"328\" height=\"277\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/16-300x253.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/16.png 417w\" sizes=\"auto, (max-width: 328px) 100vw, 328px\" \/><\/p>\n<p>\u0641\u064a \u0645\u062e\u0637\u0637 \u0627\u0644\u0640 DSC \u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a F3 (\u0627\u0644\u0634\u0643\u0644 7):<\/p>\n<p>\u0647\u0646\u0627\u0643 \u063a\u064a\u0627\u0628 \u0642\u0645\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0627\u0646\u062d\u0644\u0627\u0644\u0647 \u0627\u0644\u0643\u0627\u0645\u0644 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629\u060c \u0627\u0644\u0642\u0645\u0629 \u0627\u0644\u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 106 \u0642\u062f \u062a\u0634\u064a\u0631 \u0627\u0644\u0649 \u062a\u0628\u062e\u0631 \u0645\u0627\u0621 \u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2066 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/17-300x193.png\" alt=\"\" width=\"378\" height=\"243\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/17-300x193.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/17.png 430w\" sizes=\"auto, (max-width: 378px) 100vw, 378px\" \/><\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 <\/strong><strong>FTIR Spectroscopy<\/strong><strong>:<\/strong><\/p>\n<p>\u064a\u0648\u0636\u062d \u0627\u0644\u0634\u0643\u0644 (8)\u060c \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646\u060c \u062d\u064a\u062b \u064a\u064f\u0638\u0647\u0650\u0631 \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0627\u0644\u0639\u0637\u0631\u064a\u0629 \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f 3285\u060c \u0627\u0645\u062a\u0637\u0627\u0637 C-H \u0627\u0644\u0639\u0637\u0631\u064a\u0629 \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f\u064a\u0646 \u00a03056, 3001\u060c \u0648\u0627\u0645\u062a\u0637\u0627\u0637 C-H \u00a0\u00a0\u0627\u0644\u0623\u0644\u0641\u0627\u062a\u064a\u0629 \u0639\u0646\u062f \u0627\u0644\u0623\u0639\u062f\u0627\u062f 2969,2933,2800 \u060c \u0627\u0646\u062d\u0646\u0627\u0621 \u0631\u0627\u0628\u0637\u0629 \u0627\u0644\u0623\u0645\u064a\u0646 \u0627\u0644\u062b\u0627\u0646\u0648\u064a \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f 1592\u060c \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0631\u0627\u0628\u0637\u0629 \u0627\u0644\u0627\u064a\u0645\u064a\u0646\u064a\u0629 \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f 1549\u060c \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0631\u0627\u0628\u0637\u0629 \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0629 \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f\u064a\u0646 14321454, \u0648\u0627\u0645\u062a\u0637\u0627\u0637 \u0631\u0627\u0628\u0637\u0629 \u0627\u0644\u0623\u0645\u064a\u0646 \u0627\u0644\u062b\u0627\u0644\u062b\u064a \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f 1293\u060c \u0648\u0631\u0627\u0628\u0637\u0629 C-Cl \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f 815[22,23] .<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2067 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-3-300x185.png\" alt=\"\" width=\"425\" height=\"262\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-3-300x185.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/1-3.png 592w\" sizes=\"auto, (max-width: 425px) 100vw, 425px\" \/><\/p>\n<p>\u0641\u064a \u0637\u064a\u0641 \u0645\u0632\u064a\u062c \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a (\u0627\u0644\u0634\u0643\u0644 9)\u060c \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u0627\u0646\u0632\u064a\u0627\u062d \u0641\u064a \u0642\u0645\u0629 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0627\u0644\u0639\u0637\u0631\u064a\u0629\u060c \u0648\u0647\u0630\u0627 \u0631\u0628\u0645\u0627 \u064a\u0634\u064a\u0631 \u0627\u0644\u0649 \u062a\u062f\u0627\u062e\u0644 \u0628\u064a\u0646 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0648\u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646\u060c \u0623\u064a\u0636\u0627 \u0647\u0646\u0627\u0643 \u0627\u0646\u0632\u064a\u0627\u062d \u0641\u064a \u0642\u0645\u0629 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u0631\u0628\u0648\u0643\u0633\u064a\u0644\u064a\u0629 \u0644\u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0645\u0646 \u0627\u0644\u0639\u062f\u062f 1708 \u0627\u0644\u0649 1714 \u0645\u0639 \u0627\u0646\u062e\u0641\u0627\u0636 \u0634\u062f\u064a\u062f \u0628\u0634\u062f\u0629 \u0627\u0644\u0642\u0645\u0629 \u0648\u0638\u0647\u0648\u0631 \u0642\u0645\u0629 \u062c\u062f\u064a\u062f\u0629 \u0639\u0646\u062f \u0627\u0644\u0639\u062f\u062f \u0627\u0644\u0645\u0648\u062c\u064a 1607 \u0642\u062f \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0627\u0644\u062a\u0622\u062b\u0631 \u0623\u0648 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u064a\u0646 \u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a \u0627\u0644\u0636\u0639\u064a\u0641 \u0648\u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0642\u0644\u0648\u064a \u0627\u0644\u0636\u0639\u064a\u0641.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2068 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-2-300x201.png\" alt=\"\" width=\"416\" height=\"279\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-2-300x201.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/2-2.png 601w\" sizes=\"auto, (max-width: 416px) 100vw, 416px\" \/><\/p>\n<p>\u0623\u0645\u0627 \u0641\u064a \u0637\u064a\u0641 \u0645\u0632\u064a\u062c \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0648\u062a\u0648\u064a\u0646 80 (\u0627\u0644\u0634\u0643\u0644 10)\u060c \u0647\u0646\u0627\u0643 \u0627\u0646\u0632\u064a\u0627\u062d \u0648\u0627\u062a\u0633\u0627\u0639 \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u062f\u0627\u0644\u0629 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644 \u0641\u064a \u0627\u0644\u062a\u0648\u064a\u0646 80 \u0645\u0646 \u0627\u0644\u0639\u062f\u062f 3473 \u0627\u0644\u0649 3373 \u0648\u0623\u064a\u0636\u0627 \u0627\u0646\u0632\u064a\u0627\u062d \u0641\u064a \u0642\u0645\u0645 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0627\u0644\u0639\u0637\u0631\u064a\u0629 \u0645\u0646 \u0627\u0644\u0639\u062f\u062f \u0627\u0644\u0645\u0648\u062c\u064a 3285 \u0627\u0644\u0649 3289 \u0648\u0647\u0630\u0627 \u0631\u0628\u0645\u0627 \u064a\u0634\u064a\u0631 \u0627\u0644\u0649 \u062a\u0634\u0643\u0644 \u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644\u064a\u0629 \u0644\u0644\u062a\u0648\u064a\u0646 80 \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0644\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2069 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-3-300x199.png\" alt=\"\" width=\"445\" height=\"295\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-3-300x199.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2025\/08\/3-3.png 642w\" sizes=\"auto, (max-width: 445px) 100vw, 445px\" \/><\/p>\n<p>\u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u0648\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0635\u064a\u063a \u0648\u0627\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a\u060c \u0641\u0644\u0645 \u064a\u0644\u0627\u062d\u0638 \u062a\u063a\u064a\u0631\u0627\u062a \u062c\u0648\u0647\u0631\u064a\u0629 \u0641\u064a \u0623\u0637\u064a\u0627\u0641 \u0627\u0644\u0640 FTIR \u0648\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0644\u0644\u062f\u0648\u0627\u0621 \u0639\u0646\u062f \u0635\u064a\u0627\u063a\u062a\u0647 \u0628\u0634\u0643\u0644 \u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a.<\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/p>\n<p>\u062a\u0645\u0651\u064e \u0635\u064a\u0627\u063a\u0629 \u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0645\u064a\u0643\u0631\u0648\u064a\u0629 \u0645\u0646 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646 \u0627\u0644\u0643\u0627\u0631\u0647 \u0644\u0644\u0645\u0627\u0621\u060c \u0644\u062a\u062d\u0633\u064a\u0646 \u0627\u0646\u062d\u0644\u0627\u0644\u0647 \u0648\u062a\u0648\u0627\u0641\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a.<\/p>\n<p>\u062a\u0645\u062a\u0639\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u062b\u0628\u0627\u062a\u064a\u0629 \u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629\u060c \u0648\u0643\u0627\u0646\u062a \u0642\u064a\u0645 \u0628\u0627\u0647\u0627\u0621 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0644\u0627\u0626\u0645\u0629 \u0644\u0644\u0625\u064a\u062a\u0627\u0621 \u0627\u0644\u0623\u0646\u0641\u064a\u0651\u060c<\/p>\n<p>\u0648\u062a\u0645\u062a\u0639\u062a \u0628\u062e\u0635\u0627\u0626\u0635 \u0627\u0646\u0633\u064a\u0627\u0628 \u0645\u0646\u0627\u0633\u0628\u0629. \u0643\u0645\u0627 \u062a\u0628\u064a\u0646 \u0623\u0646\u0651 \u0632\u064a\u0627\u062f\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u0632\u064a\u062c \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u0637\u062d \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0644\u0632\u0648\u062c\u0629 \u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062d\u0636\u0631\u0629\u060c \u0648\u0632\u064a\u0627\u062f\u0629 \u0645\u0639\u062f\u0644\u0627\u062a \u062a\u062d\u0631\u0631 \u0627\u0644\u0643\u0644\u0648\u0632\u0627\u0628\u064a\u0646\u060c \u0625\u0630 \u062d\u0631\u0651\u0631\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u064a\u063a \u0628\u0634\u0643\u0644 \u0645\u0633\u062a\u062f\u064a\u0645 \u0644\u0644\u062f\u0648\u0627\u0621 \u062e\u0644\u0627\u0644 24 \u0633\u0627\u0639\u0629. \u062a\u0645\u0651 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0641\u064a \u0627\u0644\u0635\u064a\u063a \u0648\u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0645\u0644\u0627\u0626\u0645\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0633\u0631\u064a\u0631\u064a.<\/p>\n<p><strong>\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a <\/strong><strong>List of abbreviations<\/strong><\/p>\n<table style=\"width: 72.5119%;\">\n<tbody>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\"><strong>\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u0628\u0627\u0644\u0644\u0651\u063a\u0629 \u0627\u0644\u0639\u0631\u0628\u064a\u0651\u0629<\/strong><\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\"><strong>\u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631<\/strong><\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\"><strong>\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u0628\u0627\u0644\u0644\u0651\u063a\u0629 \u0627\u0644\u0625\u0646\u0643\u0644\u064a\u0632\u064a\u0651\u0629<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0627\u0644\u062d\u0627\u062c\u0632 \u0627\u0644\u062f\u0645\u0648\u064a \u0627\u0644\u062f\u0645\u0627\u063a\u064a<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">BBB<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Blood Brain Barrier<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0627\u0644\u062a\u0635\u0646\u064a\u0641 \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a \u0627\u0644\u062d\u064a\u0648\u064a<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">BCS<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Biopharmaceutical Classification System<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0627\u0644\u0645\u0627\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0651\u0641\u0627\u0636\u0644\u064a<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">DSC<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Differential scanning calorimetry<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">DC<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Drug content<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u062a\u062d\u0648\u064a\u0644 \u0641\u0648\u0631\u064a\u064a\u0647 \u0641\u064a \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0651\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">FTIR<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Fourier transform infrared spectroscopy<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0631\u0643\u0632\u064a<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">CNS<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Central Nervous System<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0627\u0644\u0645\u0633\u062a\u062d\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a\u0629<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">ME<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Microemulsion<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u063a\u064a\u0631 \u0642\u0627\u0628\u0644 \u0644\u0644\u062a\u0637\u0628\u064a\u0642<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">N\/A<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Not Applicable<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u062d\u0645\u0636 \u0627\u0644\u0632\u064a\u062a<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">OA<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Oleic Acid<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0628\u0648\u0644\u064a \u0627\u064a\u062b\u064a\u0644\u064a\u0646 \u063a\u0644\u064a\u0643\u0648\u0644 400<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">PEG 400<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Polyethylene Glycol 400<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0645\u064e\u0646\u0633\u064e\u0628 \u0627\u0644\u062a\u0634\u062a\u0651\u064f\u062a \u0627\u0644\u0645\u062a\u0639\u062f\u062f<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">PDI<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Polydispersity Index<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0643\u0631\u064a P<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">Pgp<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">P-glycoprotein<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0645\u062c\u0647\u0631 \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0645\u0627\u0633\u062d<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">SEM<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Scanning electron microscope<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0645\u0632\u064a\u062c \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0633\u0637\u062d\u064a\u0627\u064b \u0648\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">Smix<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">Surfactant, Co-surfactant mixture<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">USP<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">United States Pharmacopeia<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45.8144%; text-align: center;\" width=\"101\">\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629<\/td>\n<td style=\"width: 11.4708%; text-align: center;\" width=\"72\">WHO<\/td>\n<td style=\"width: 139.879%; text-align: center;\" width=\"137\">World Health Organization<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627<\/strong><strong>\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629<\/strong><strong> \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 <\/strong><strong>Ethics<\/strong><\/p>\n<p><strong>approval and consent to participate<\/strong><\/p>\n<p>\u063a\u064a\u0631 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong><strong>Conflict of interests<\/strong><\/p>\n<p>\u064a\u0642\u0631\u064f \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u064f\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong><strong>Funding<\/strong><\/p>\n<p>\u0645\u064f\u0648\u0651\u0650\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u0642\u0628\u0644 \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong><strong>Author\u2019s contributions<\/strong><\/p>\n<p>\u062a\u0648\u0644\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u0629 (\u0645\u064a\u0631\u064a \u0631\u064a\u0627\u0636 \u0627\u0644\u062f\u064a\u0631) \u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0646\u0634\u0637\u0629 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u062c\u0645\u0639 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a\u060c \u0627\u0644\u062a\u0651\u062d\u0644\u064a\u0644\u060c \u0648\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0645\u0642\u0627\u0644.<\/p>\n<p>\u0643\u0627\u0646 \u0627\u0644\u0645\u0634\u0631\u0641 (\u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0645\u062d\u0645\u062f \u0639\u0628\u062f \u0627\u0644\u0631\u0624\u0648\u0641 \u0639\u062b\u0645\u0627\u0646) \u0645\u0633\u0624\u0648\u0644\u0627\u064b \u0639\u0646 \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0625\u0631\u0634\u0627\u062f\u0627\u062a \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629\u060c \u0648\u0636\u0645\u0627\u0646 \u062c\u0648\u062f\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0633\u0648\u062f\u0629 \u0627\u0644\u0646\u0651\u0647\u0627\u0626\u064a\u0629.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u0648\u0641\u0642\u064b\u0627 \u0644\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 (WHO)\u060c \u064a\u0639\u0627\u0646\u064a \u062d\u0648\u0627\u0644\u064a 20 \u0645\u0644\u064a\u0648\u0646 \u0634\u062e\u0635 \u0645\u0646 \u0645\u0631\u0636 \u0627\u0644\u0641\u0635\u0627\u0645 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645\u060c \u0643\u0645\u0627 \u0623\u0646 \u0627\u0644\u0623\u0634\u062e\u0627\u0635&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=2054\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2070,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-157","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2054"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2054\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2070"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}