{"id":207,"date":"2022-01-01T08:12:15","date_gmt":"2022-01-01T08:12:15","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=207"},"modified":"2024-07-21T17:28:34","modified_gmt":"2024-07-21T17:28:34","slug":"%d9%82%d9%8a%d8%a7%d8%b3-%d8%aa%d8%b1%d9%83%d9%8a%d8%b2-%d9%85%d8%b4%d8%aa%d9%82%d8%a7%d8%aa-%d8%a7%d9%84%d8%a8%d8%a7%d8%b1%d8%a7%d8%a8%d9%8a%d9%86-%d9%81%d9%8a-%d8%b9%d9%8a%d9%91%d9%86%d8%a7%d8%aa","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=207","title":{"rendered":"\u0642\u064a\u0627\u0633 \u062a\u0631\u0643\u064a\u0632 \u0645\u0634\u062a\u0642\u0627\u062a \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0639\u064a\u0651\u0646\u0627\u062a \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u064f\u0631\u0641 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0645\u0646 \u0642\u0628\u0644 \u062b\u064a\u0648\u062f\u0648\u0631 \u0633\u0627\u0628\u0627\u0644\u064a\u062a\u0634\u0643\u0627 \u0641\u064a \u0639\u0627\u0645 1920\u060c \u0648\u0645\u0646\u0630 \u0630\u0644\u0643 \u0627\u0644\u062d\u064a\u0646\u060c \u0627\u0633\u062a\u062e\u062f\u0645 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0639\u0644\u0649 \u0623\u0646\u0651\u0647 \u0645\u0627\u062f\u0651\u0629 \u062d\u0627\u0641\u0638\u0629 \u0641\u064a \u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u062a\u062c\u0645\u064a\u0644 \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0648\u0627\u0644\u0645\u0646\u0638\u0641\u0627\u062a \u0648\u0627\u0644\u0639\u0637\u0648\u0631 \u0648\u0627\u0644\u062d\u0644\u0648\u064a\u0627\u062a \u0648\u0627\u0644\u0623\u0637\u0639\u0645\u0629 \u0627\u0644\u0645\u0639\u0644\u0628\u0629\u060c \u0648\u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0639\u0644\u0628\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 [1] [2]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u062a\u0645\u064a\u0632 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0628\u062e\u0635\u0627\u0626\u0635\u0647 \u0627\u0644\u0642\u0648\u064a\u0629 \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u062c\u0631\u0627\u062b\u064a\u0645 \u0648\u0627\u0644\u0641\u0637\u0631\u0628\u0627\u062a \u0636\u0645\u0646 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0645\u0646 \u0627\u0644 PH (4.5-7.5)\u060c \u0643\u0645\u0627 \u0623\u0646\u0647 \u0639\u062f\u064a\u0645 \u0627\u0644\u0631\u0627\u0626\u062d\u0629 \u0648 \u0644\u0627 \u064a\u0633\u0628\u0628 \u062a\u063a\u064a\u0651\u0631\u0627\u064b \u0641\u064a \u0644\u0648\u0646 \u0627\u0644\u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u0641 \u0625\u0644\u064a\u0647\u0627\u060c \u0648\u063a\u064a\u0631 \u0645\u0643\u0644\u0641 \u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0635\u0646\u064a\u0639\u060c \u0648\u0645\u0633\u062a\u0642\u0631 \u0641\u064a \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0645\u0637\u0644\u0648\u0628\u0629 \u0644\u0644\u0625\u0646\u062a\u0627\u062c [3]\u060c \u0647\u0630\u0627 \u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u062c\u064a\u062f \u0636\u062f \u0627\u0644\u0638\u0631\u0648\u0641 \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629\u060c \u0628\u062c\u0627\u0646\u0628 \u062a\u0643\u0627\u0644\u064a\u0641 \u0627\u0644\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629 \u0644\u0644\u063a\u0627\u064a\u0629\u060c \u064f\u064a\u0641\u0633\u0631 \u0633\u0628\u0628 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0628\u0634\u0643\u0644 \u0634\u0627\u0626\u0639 [3]\u060c \u062a\u0632\u062f\u0627\u062f \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0628\u0632\u064a\u0627\u062f\u0629 \u0637\u0648\u0644 \u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0623\u0644\u0643\u064a\u0644 \u0645\u0646 \u0645\u064a\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0625\u0644\u0649 \u0628\u0648\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 [3] [4]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u062a\u0649 \u0627\u0644\u0622\u0646 \u0645\u0627\u062a\u0632\u0627\u0644 \u0622\u0644\u064a\u0629 \u0639\u0645\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0639\u0644\u0649 \u0623\u0646\u0651\u0647 \u0645\u0627\u062f\u0651\u0629 \u062d\u0627\u0641\u0638\u0629 \u063a\u064a\u0631 \u0645\u0641\u0647\u0648\u0645\u0629\u060c \u064a\u0645\u0643\u0646 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0623\u0646 \u064a\u0639\u0628\u0631 \u0627\u0644\u0623\u063a\u0634\u064a\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u062b\u0645 \u064a\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0627\u0644\u0627\u0635\u0637\u0646\u0627\u0639 \u0627\u0644\u062d\u064a\u0648\u064a \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0645\u0624\u062f\u064a\u0627\u064b \u0625\u0644\u0649 \u062a\u0639\u0637\u064a\u0644 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0644\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u062c\u0631\u062b\u0648\u0645\u064a\u0629 \u0648\u0627\u0644\u062a\u0633\u0628\u0628 \u0641\u064a \u0645\u0648\u062a\u0647\u0627 [3]\u060c \u064a\u064f\u0641\u062a\u0631\u0636 \u0628\u0623\u0646\u0647 \u064a\u0642\u0648\u0645 \u0628\u062a\u0639\u0637\u064a\u0644 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0646\u0642\u0644 \u0639\u0628\u0631 \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u062e\u0644\u0648\u064a\u060c \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062b\u0628\u064a\u0637 \u0627\u0635\u0637\u0646\u0627\u0639 \u0627\u0644 DNA \u0648\u0627\u0644RNA\u00a0 \u0623\u0648 \u0628\u0639\u0636 \u0627\u0644\u0623\u0646\u0632\u064a\u0645\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0645\u062b\u0644 ATPases \u0648 phosphotransferases \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u062c\u0631\u062b\u0648\u0645\u064a\u0629 [5]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u064f\u0639\u0631\u0641 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646\u0627\u062a (PBs) \u0623\u0646\u0647\u0627 \u0627\u0633\u062a\u0631\u0627\u062a \u0628\u0627\u0631\u0627 -\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u062d\u0645\u0636 \u0627\u0644\u0628\u0646\u0632\u0648\u064a\u0643 (pHBA) \u060c \u0627\u0644\u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u064b\u0627 \u0645\u0646\u0647\u0627:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u064a\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 (MePB) E218<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0625\u064a\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 (EtPB) E214<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0631\u0648\u0628\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 (PrPB) E216<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0648\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 (BuPB) E209<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0646\u0632\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u0647\u0648 \u0627\u0644\u0623\u0642\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u064b\u0627.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0639\u062f \u0645\u062a\u064a\u0644 \u0648\u0628\u0631\u0648\u0628\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0627\u0644\u0623\u0643\u062b\u0631 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0627\u064b \u0648\u063a\u0627\u0644\u0628\u0627\u064b \u0645\u0627\u064a\u0648\u062c\u062f\u0627\u0646 \u0645\u0639\u0627\u064b \u0641\u064a \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a ]6[ ]7[.<\/span><\/p>\n<figure id=\"attachment_641\" aria-describedby=\"caption-attachment-641\" style=\"width: 394px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-641\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-9-300x181.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 1. \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646\" width=\"394\" height=\"238\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-9-300x181.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-9.png 310w\" sizes=\"auto, (max-width: 394px) 100vw, 394px\" \/><figcaption id=\"caption-attachment-641\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 1. \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0630\u0648\u0628\u0627\u0646\u0627\u064b \u0636\u0639\u064a\u0641\u0627\u064b \u0641\u064a \u0627\u0644\u0645\u0627\u0621\u060c \u0648\u0639\u0627\u0644\u064a\u0627\u064b \u0641\u064a \u0627\u0644\u062f\u0633\u0645\u060c \u062d\u064a\u062b \u062a\u0632\u062f\u0627\u062f \u0627\u0646\u062d\u0644\u0627\u0644\u064a\u062a\u0647 \u0628\u0627\u0644\u062f\u0633\u0645 \u0628\u0627\u0632\u062f\u064a\u0627\u062f \u0637\u0648\u0644 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0644\u0644\u0625\u0633\u062a\u0631\u060c \u0641\u0642\u062f \u064a\u0624\u062f\u064a \u0647\u0630\u0627 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u062a\u0631\u0627\u0643\u0645\u0647 \u0641\u064a \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062f\u0633\u0645\u0629 \u0641\u064a \u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062c\u0633\u0645 \u0628\u0637\u0631\u064a\u0642\u0629 \u0645\u0634\u0627\u0628\u0647\u0629 \u0644\u0644\u0645\u0644\u0648\u062b\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u0645\u062d\u0628\u0629 \u0644\u0644\u062f\u0633\u0645 \u0648\u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0628\u0641\u0639\u0644 \u062a\u0631\u0627\u0643\u0645\u064a [8]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u064a \u0627\u0644\u0622\u0648\u0646\u0629 \u0627\u0644\u0623\u062e\u064a\u0631\u0629\u060c \u0627\u0632\u062f\u0627\u062f \u0627\u0644\u062c\u062f\u0627\u0644 \u062d\u0648\u0644 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a\u060c \u062e\u0627\u0635\u0629 \u0628\u0639\u062f \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0645\u0646 \u062c\u0647\u0629 \u0648\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0645\u0646 \u062c\u0647\u0629 \u0623\u062e\u0631\u0649\u060c \u062d\u064a\u062b \u064a\u062d\u0627\u0643\u064a \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u062a\u0623\u062b\u064a\u0631 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0639\u0646\u062f \u0627\u0631\u062a\u0628\u0627\u0637\u0647 \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u062b\u062f\u064a\u060c \u0645\u0645\u0627 \u064a\u062a\u0633\u0628\u0628 \u0641\u064a \u0627\u062e\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0648\u0627\u0632\u0646 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0627\u0644\u0630\u064a \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0643\u0627\u062b\u0631 \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a \u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062b\u062f\u064a [8]\u060c \u0644\u0627 \u062a\u0642\u062a\u0635\u0631 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u062b\u062f\u064a\u060c \u062d\u064a\u062b \u0639\u064f\u062b\u0631 \u0639\u0644\u0649 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0623\u062c\u0632\u0627\u0621 \u0643\u062b\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633[9] . <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0624\u062f\u0651\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u062f\u0648\u0631\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0641\u064a \u0627\u0644\u062a\u0648\u0627\u0632\u0646 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0644\u0644\u062c\u0633\u0645 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646\u060c \u0648\u062a\u0646\u0638\u064a\u0645 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0633\u0643\u0631 \u0641\u064a \u0627\u0644\u062f\u0645 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0633\u0647\u064a\u0644 \u0645\u0631\u0648\u0631\u0647 \u0625\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0639\u062a\u0628\u0631 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0645\u0631\u0636\u0627\u064b \u0642\u0627\u062a\u0644\u0627\u064b\u060c \u062d\u064a\u062b \u062a\u0635\u0644 \u0646\u0633\u0628\u0629 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0625\u0644\u0649 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 100\u066a\u060c \u0643\u0645\u0627 \u0623\u0646\u0647 \u064a\u062d\u062a\u0644 \u0627\u0644\u0645\u0631\u062a\u0628\u0629 \u0627\u0644\u0631\u0627\u0628\u0639\u0629 \u0641\u064a \u0645\u0639\u062f\u0644 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u062c\u062a\u0645\u0639\u0627\u062a \u0627\u0644\u063a\u0631\u0628\u064a\u0629\u060c \u0648\u0647\u0648 \u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u064b\u0627 \u0628\u064a\u0646 \u0627\u0644\u0631\u062c\u0627\u0644 \u0627\u0644\u0623\u0635\u063a\u0631 \u0633\u0646\u064b\u0627 \u0645\u0646\u0647 \u0628\u064a\u0646 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0623\u0635\u063a\u0631 \u0633\u0646\u064b\u0627. \u0641\u064a \u0645\u0639\u0638\u0645 \u0627\u0644\u0628\u0644\u062f\u0627\u0646\u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u0645\u0639 \u0627\u0644\u062a\u0642\u062f\u0645 \u0628\u0627\u0644\u0639\u0645\u0631 \u062a\u0635\u0628\u062d \u0627\u0644\u0646\u0633\u0628\u0629 \u0645\u062a\u0633\u0627\u0648\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u062c\u0646\u0633\u064a\u0646. \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641\u0647 \u0641\u0642\u0637 \u0639\u0646\u062f\u0645\u0627 \u064a\u0646\u062a\u0634\u0631 \u0625\u0644\u0649 \u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0623\u062e\u0631\u0649 &#8211; \u0645\u062b\u0644 \u0627\u0644\u0643\u0628\u062f [11] [10]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u064a\u0633 \u0647\u0646\u0627\u0643 \u0634\u0643 \u0641\u064a \u0648\u062c\u0648\u062f \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER) \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0631\u0627\u0628\u0637 \u0644\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0627\u0644\u0628\u0634\u0631\u064a \u0627\u0644\u0633\u0644\u064a\u0645\u060c \u062d\u064a\u062b \u062b\u0628\u062a \u0623\u0646\u0647 \u0627\u0644\u0645\u0645\u0643\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 [11] . <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0623\u0646\u0651 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0639\u0646\u062f \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u064a\u064f\u0639\u0628\u0631 \u0639\u0646 \u0646\u0648\u0639\u064a\u0646 \u0641\u0631\u0639\u064a\u064a\u0646 \u0645\u0646 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0647\u0645\u0627 [ER\u03b1] \u0648[ER\u03b2] \u060c \u0648\u0643\u0644 \u0646\u0648\u0639 \u0641\u0631\u0639\u064a \u0645\u0646\u00a0 ER \u0642\u0627\u062f\u0631 \u0639\u0644\u0649 \u062a\u0645\u064a\u064a\u0632 \u0625\u0634\u0627\u0631\u0627\u062a \u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0645\u062a\u0645\u064a\u0632\u0629\u060c \u0645\u0645\u0627 \u064a\u0639\u0632\u0632 \u062f\u0648\u0631 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u060c \u0643\u0645\u0627 \u0623\u0646 \u0645\u0639\u0638\u0645 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u064f\u0639\u0628\u0631 \u0639\u0646 ER\u03b2 \u0628\u0646\u0633\u0628\u0629 \u0623\u0643\u0628\u0631 \u0645\u0646 ER\u03b1\u00a0 .[9] <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0642\u062f \u062a\u0623\u0643\u062f\u0651 \u0623\u0646 \u0644\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u062f\u0648\u0631\u064b\u0627 \u0641\u064a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 [12] \u060c \u0648\u0628\u0645\u0627 \u0623\u0646 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u064a\u0645\u062a\u0644\u0643 \u062e\u0635\u0627\u0626\u0635 \u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u060c \u0641\u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0644\u0647 \u062f\u0648\u0631 \u0641\u064a \u062a\u0637\u0648\u0631 \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u064a \u0623\u063a\u0644\u0628 \u0627\u0644\u0645\u0631\u0627\u062c\u0639 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u062a\u062d\u062f\u062f \u0643\u0645\u064a\u0629 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0643\u0633\u0648\u0627\u063a \u0645\u0636\u0627\u0641 \u0644\u0644\u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0643\u0627\u0644\u062a\u0627\u0644\u064a[13] :<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u062a\u064a\u0644 \u0628\u0627\u0631\u0627\u0628\u064a\u06460.2-0.015 %<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0628\u0631\u0648\u0628\u064a\u0644 \u0628\u0627\u0631\u0627\u0628\u064a\u0646:<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">01-0.02 % \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u0633\u0627\u0626\u0644\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">01-0.6 % \u0641\u064a \u0627\u0644\u062a\u0631\u0643\u064a\u0628\u0627\u062a \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">005-0.2 % \u0641\u064a \u0627\u0644\u062d\u0642\u0646<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u063a\u0627\u0644\u0628\u0627\u064b \u0645\u0627\u062a\u0643\u0648\u0646 \u0645\u0634\u0627\u0631\u0643\u0629 \u0627\u0644\u0645\u062a\u064a\u0644 \u0648\u0627\u0644\u0628\u0631\u0648\u0628\u064a\u0644 \u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0628\u0646\u0633\u0628: 1 PP:3 MP\u060c 3 PP:7 MP \u060c 1 PP:7 MP <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0639\u062a\u0642\u062f \u0623\u0646 \u0648\u062c\u0648\u062f \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u063a\u064a\u0631 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0647\u0648 \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0633\u0627\u0645\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 [ [15] [14. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0645\u0648\u0645\u0627\u064b \u0641\u0625\u0646 \u0627\u0644\u062a\u062f\u0627\u0628\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0643\u0631\u064a \u062a\u0634\u0645\u0644 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0648\u0645\u062d\u0641\u0632\u0627\u062a \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u0646 \u0635\u0646\u0641 \u0645\u062d\u0627\u0643\u064a\u0627\u062a \u0627\u0644\u0625\u0646\u0643\u0631\u064a\u062a\u064a\u0646 [16]\u060c \u062b\u0645\u0629 \u0628\u062d\u0648\u062b \u0639\u062f\u064a\u062f\u0629 \u062a\u0642\u062a\u0631\u062d \u0639\u0644\u0627\u0642\u0629 \u0633\u0628\u0628\u064a\u0629 \u0628\u064a\u0646 \u0628\u0639\u0636 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u0643\u0631\u064a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062b\u0627\u0646\u064a \u0643\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u0646 \u0635\u0646\u0641 \u0627\u0644\u0625\u0646\u0643\u0631\u064a\u062a\u064a\u0646 incretin mimetic class \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633\u060c \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0625\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0644\u0645 \u062a\u0646\u062a\u0647 \u0627\u0644\u0649 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0642\u062f \u062a\u0633\u0628\u0628 \u0623\u0648 \u062a\u0633\u0647\u0645 \u0641\u064a \u062a\u0637\u0648\u0631 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633\u060c \u062d\u064a\u062b \u064a\u0639\u062a\u0645\u062f \u0639\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0645\u062d\u0627\u0643\u0627\u0629 \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0625\u0646\u0643\u0631\u064a\u062a\u064a\u0646 \u0627\u0644\u062a\u064a \u064a\u0646\u062a\u062c\u0647\u0627 \u0627\u0644\u062c\u0633\u0645 \u0639\u0627\u062f\u0629 \u0628\u0634\u0643\u0644 \u0637\u0628\u064a\u0639\u064a \u0644\u062a\u062d\u0641\u064a\u0632 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0629\u064b \u0644\u0644\u0648\u062c\u0628\u0629\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u062c\u0646\u0628\u064b\u0627 \u0625\u0644\u0649 \u062c\u0646\u0628 \u0645\u0639 \u0627\u0644\u0646\u0638\u0627\u0645 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0648\u0645\u0645\u0627\u0631\u0633\u0629 \u0627\u0644\u0631\u064a\u0627\u0636\u0629 \u0644\u062e\u0641\u0636 \u0646\u0633\u0628\u0629 \u0627\u0644\u0633\u0643\u0631 \u0641\u064a \u0627\u0644\u062f\u0645 \u0644\u062f\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0631\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 2 [17] . <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0639\u062a\u0628\u0631 \u0627\u0644\u0646\u0638\u0627\u0645 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u062c\u0632\u0621 \u0641\u0639\u0627\u0644 \u0645\u0646 \u0627\u0644\u062e\u0637\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629\u060c \u062d\u064a\u062b \u064a\u062a\u0636\u0645\u0646 \u0627\u0644\u062e\u0636\u0631\u0648\u0627\u062a \u0648\u0639\u0635\u0627\u0626\u0631 \u0627\u0644\u0641\u0648\u0627\u0643\u0647 \u0628\u062f\u0648\u0646 \u0633\u0643\u0631 \u0648\u0627\u0644\u0623\u063a\u0630\u064a\u0629 \u0627\u0644\u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u0623\u0644\u064a\u0627\u0641 \u0648\u0627\u0644\u0623\u063a\u0630\u064a\u0629 \u0642\u0644\u064a\u0644\u0629 \u0627\u0644\u0633\u0639\u0631\u0627\u062a \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0648\u0627\u0644\u0642\u0644\u064a\u0644\u0629 \u0627\u0644\u062f\u0633\u0645 \u0648\u0627\u0644\u0633\u0645\u0643 \u0648\u0627\u0644\u062d\u0628\u0648\u0628\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062d\u0644\u064a\u0628 \u0648\u0627\u0644\u0644\u0628\u0646 \u0645\u0646\u062e\u0641\u0636\u064a \u0627\u0644\u062f\u0633\u0645\u00a0 [16]. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0642\u062f \u064a\u062a\u0639\u0631\u0636 \u0627\u0644\u0634\u062e\u0635 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0645\u0646 \u0627\u0644\u0623\u063a\u0630\u064a\u0629 \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0646\u0627\u0648\u0644\u0629 \u0641\u0645\u0648\u064a\u0627\u064b \u0648\u062e\u0635\u0648\u0635\u0627\u064b \u062a\u0644\u0643 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0632\u0645\u0646\u0629\u060c \u0646\u0638\u0631\u0627\u064b \u0644\u0643\u0648\u0646 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u064a\u062f\u062e\u0644 \u0628\u0648\u0635\u0641\u0647 \u0645\u0627\u062f\u0651\u0629 \u062d\u0627\u0641\u0638\u0629 \u0641\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u063a\u0630\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0639\u0644\u0628\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629\u060c \u0643\u0645\u0627 \u0623\u0646 \u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0645\u0648\u0636\u0639\u064a \u0644\u0644\u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062c\u0631\u0648\u062d \u0627\u0644\u062a\u064a \u064a\u0639\u0627\u0646\u064a \u0645\u0646\u0647\u0627 \u0623\u063a\u0644\u0628 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0643\u0631\u064a \u0648\u062e\u0635\u0648\u0635\u0627\u064b \u0627\u0644\u0642\u062f\u0645 \u0627\u0644\u0633\u0643\u0631\u064a\u0629\u060c \u0642\u062f \u062a\u0634\u0643\u0644 \u0645\u0635\u062f\u0631\u0627\u064b \u0622\u062e\u0631 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0627\u0644\u062f\u0627\u062e\u0644 \u0644\u0644\u062c\u0633\u0645\u060c \u0648\u0645\u0646 \u062b\u0645\u0651 \u0641\u0625\u0646\u0651 \u0647\u0630\u0627 \u0642\u062f \u064a\u0632\u064a\u062f \u0645\u0646 \u062f\u0648\u0631 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u062a\u0623\u062b\u064a\u0631\u0647 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0647\u062f\u0641 \u0627\u0644\u062f\u0631\u0627\u0633\u0629:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u062a\u062d\u0631\u064a \u0639\u0646 \u0648\u062c\u0648\u062f \u0645\u0634\u062a\u0642\u0627\u062a \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 (\u0645\u062a\u064a\u0644\u060c \u0627\u064a\u062a\u064a\u0644 \u0648\u0628\u0631\u0648\u0628\u064a\u0644) \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u0642\u064a\u0627\u0633 \u062a\u0631\u0627\u0643\u064a\u0632\u0647\u0627.<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u064f\u0645\u0639\u062a \u0639\u064a\u0646\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0645\u0628\u0627\u0634\u0631\u0629 \u0628\u0639\u062f \u0627\u0644\u062c\u0631\u0627\u062d\u0629\u060c \u062c\u0631\u0649 \u0630\u0644\u0643 \u0641\u064a \u0642\u0633\u0645 \u0627\u0644\u062c\u0631\u0627\u062d\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0641\u064a \u0645\u0634\u0641\u0649 \u0627\u0644\u0623\u0633\u062f \u0627\u0644\u062c\u0627\u0645\u0639\u064a\u060c \u062b\u0645 \u062e\u064f\u0632\u0646\u062a \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 (-80 \u0645o)\u060c \u0644\u0627\u062d\u0642\u0627\u064b \u062a\u0645 \u0627\u0633\u062a\u062e\u0631\u0627\u062c \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u062a\u062d\u0644\u064a\u0644\u0647\u0627 \u0628\u0648\u0627\u0633\u0637\u0629:<\/span><span style=\"font-family: 'times new roman', times, serif;\">\u00a0HPLC \/ MS (SHIMADZU LC MS-2020) \u0641\u064a \u0645\u062e\u0628\u0631 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0627\u0644\u0645\u0631\u0643\u0632\u064a \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0648\u0645 &#8211; \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0623\u0648\u0644:<\/strong> \u062a\u064f\u0624\u062e\u0630 \u0627\u0644\u0639\u064a\u0646\u0629 (0.5 \u0645\u0644\u063a) \u062b\u0645 \u062a\u0642\u0637\u0639 \u062c\u064a\u062f\u0627\u064b \u0648\u062a\u062c\u0627\u0646\u0633 \u0645\u0639 (6.25 \u0645\u0644 \u0625\u064a\u062a\u0627\u0646\u0648\u0644 + 6.25 \u0645\u0644 \u0623\u0633\u064a\u062a\u0648\u0646)\u060c \u062a\u062a\u0631\u0643 \u0643\u0644 \u0627\u0644\u0644\u064a\u0644 \u0628\u0627\u0644\u0647\u0632\u0627\u0632\u0629 \u0627\u0644\u062f\u0648\u0631\u064a\u0629 (periodic shaking) \u0641\u064a \u0623\u0646\u0628\u0648\u0628 \u0632\u062c\u0627\u062c\u064a \u0645\u063a\u0644\u0642.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062b\u0627\u0646\u064a:<\/strong> \u064a\u064f\u0648\u0636\u0639 \u0627\u0644\u062e\u0644\u064a\u0637 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u0631\u062f \u0627\u0644\u0645\u0631\u0643\u0632\u064a ((bench centrifuge \u0628\u0633\u0631\u0639\u0629 2500 \u062f\u0648\u0631\u0629\/\u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0645\u062f\u0629\u00a0\u00a0\u00a0\u00a0\u00a0 10 \u062f\u0642\u0627\u0626\u0642 \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629\u060c \u062b\u0645 \u062a\u0624\u062e\u0630 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u0637\u0627\u0641\u064a\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u062a\u064f\u0648\u0636\u0639 \u0641\u064a \u0623\u0646\u0628\u0648\u0628 \u0646\u0638\u064a\u0641\u060c \u0628\u064a\u0646\u0645\u0627 \u064a\u064f\u0639\u0627\u062f \u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0627\u0644\u0643\u062a\u0644\u0629 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629 \u0628\u0625\u0636\u0627\u0641\u0629 (1.5 \u0645\u0644 \u0625\u064a\u062a\u0627\u0646\u0648\u0644 + 1.5 \u0645\u0644 \u0623\u0633\u064a\u062a\u0648\u0646)\u060c \u0648\u062a\u064f\u0636\u0639 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u0631\u062f \u0627\u0644\u0645\u0631\u0643\u0632\u064a\u00a0 \u0644\u0645\u062f\u0629 10 \u062f\u0642\u0627\u0626\u0642 \u0628\u0633\u0631\u0639\u0629 2500 \u062f\u0648\u0631\u0629\/\u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629\u060c \u062a\u064f\u0641\u0635\u0644 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u0637\u0627\u0641\u064a\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0623\u0646\u0628\u0648\u0628 \u0646\u0638\u064a\u0641\u060c \u062b\u0645 \u062a\u064f\u062c\u0645\u0639 \u0627\u0644\u0637\u0628\u0642\u062a\u0627\u0646 \u0627\u0644\u0637\u0627\u0641\u064a\u062a\u0627\u0646 \u0627\u0644\u0633\u0627\u0628\u0642\u062a\u0627\u0646 \u0645\u0639\u0627\u064b\u060c \u0648\u064a\u062a\u0645 \u062a\u062c\u0641\u064a\u0641\u0647\u0645\u0627 \u062d\u062a\u0649 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u062e\u0644\u0627\u0635\u0629 \u062c\u0627\u0641\u0629 \u0632\u064a\u062a\u064a\u0629 \u0627\u0644\u0642\u0648\u0627\u0645 \u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062b\u0627\u0644\u062b:<\/strong> \u062a\u064f\u062e\u0644\u0637 \u0627\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u0632\u064a\u062a\u064a\u0629 \u0645\u0639 ( 6 \u0645\u0644 \u0645\u064a\u062a\u0627\u0646\u0648\u0644 \u0645\u0627\u0626\u064a 70\u066a)\u060c \u0648\u062a\u064f\u062d\u0636\u0646 \u0643\u0644 \u0627\u0644\u0644\u064a\u0644 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 (-20 \u0645o).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0631\u0627\u0628\u0639:<\/strong> \u064a\u064f\u0648\u0636\u0639 \u0627\u0644\u062e\u0644\u064a\u0637 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u0631\u062f \u0627\u0644\u0645\u0631\u0643\u0632\u064a \u0628\u0633\u0631\u0639\u0629 3200 \u062f\u0648\u0631\u0629\/ \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0645\u062f\u0629 20 \u062f\u0642\u064a\u0642\u0629 \u0639\u0646\u062f (4 \u0645o)\u060c \u062b\u0645 \u062a\u064f\u0641\u0635\u0644 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u0637\u0627\u0641\u064a\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u062a\u0648\u0636\u0639 \u0641\u064a \u0623\u0646\u0628\u0648\u0628 \u0646\u0638\u064a\u0641\u060c \u062b\u0645 \u064a\u064f\u0639\u0627\u062f \u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0627\u0644\u062e\u0644\u0627\u0635\u0629 \u0627\u0644\u0632\u064a\u062a\u064a\u0629 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0628\u0625\u0636\u0627\u0641\u0629 ( 1\u0645\u0644 \u0645\u064a\u062a\u0627\u0646\u0648\u0644 \u0645\u0627\u062b\u064a 70%) \u0648 \u0648\u0636\u0639\u0647\u0627 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0637\u0631\u062f \u0627\u0644\u0645\u0631\u0643\u0632\u064a \u0628\u0633\u0631\u0639\u0629 3200 \u062f\u0648\u0631\u0629 \/\u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0645\u062f\u0629 20 \u062f\u0642\u064a\u0642\u0629 \u0639\u0646\u062f (4 \u0645o) \u060c \u062a\u064f\u0624\u062e\u0630 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u0637\u0627\u0641\u064a\u0629 \u0627\u0644\u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646\u060c \u062b\u0645 \u062a\u064f\u062f\u0645\u062c \u0627\u0644\u0637\u0628\u0642\u062a\u0627\u0646 \u0627\u0644\u0639\u0644\u0648\u064a\u0651\u062a\u0627\u0646 \u0648\u062a\u062c\u0641\u0642\u0627\u0646 \u0641\u064a \u0627\u0644\u0647\u0648\u0627\u0621 \u0627\u0644\u0637\u0644\u0642\u060c \u062d\u064a\u062b \u062a\u0643\u0648\u0646 \u0627\u0644\u0639\u064a\u0646\u0629 \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u062d\u0627\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062e\u0627\u0645\u0633:<\/strong> \u062a\u064f\u0624\u062e\u0630 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u062c\u0627\u0641\u0629 \u0648\u062a\u064f\u062d\u0644 \u0628\u0627\u0644\u0645\u064a\u062a\u0627\u0646\u0648\u0644 \u0644\u062a\u062d\u0644\u0651\u0644 \u0628\u0648\u0627\u0633\u0637\u0629. HPLC \/ MS<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0643\u0648\u0627\u0634\u0641 \u0648\u0627\u0644\u0645\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0627\u0644\u062a\u062d\u0644\u064a\u0644:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629: \u0645\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646\u060c \u0627\u064a\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646\u060c \u0628\u0631\u0648\u0628\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 Roth, Germany))<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0636\u0645 \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0645\u062a\u062d\u0631\u0643 \u0644\u062c\u0647\u0627\u0632 HPLC\/MS:<\/span>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062e\u0644\u0627\u062a \u0627\u0644\u0623\u0645\u0648\u0646\u064a\u0648\u0645 Ammonium Acetate (15 mM\u060c PH=4.5) \u0641\u064a \u0627\u0644\u0645\u0636\u062e\u0629 A<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0623\u0633\u064a\u062a\u0648 \u0646\u062a\u0631\u064a\u0644 Acetonitrile \u0641\u064a \u0627\u0644\u0645\u0636\u062e\u0629 B<\/span><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0648\u0639 \u0627\u0644\u0639\u0645\u0648\u062f C18, 150 mm \u060c \u062d\u062c\u0645 \u0627\u0644\u062d\u0628\u064a\u0628\u0627\u062a \u00b5m 5<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0642\u064a\u0627\u0633 254 \u0646\u0627\u0646\u0648 \u0645\u062a\u0631\u060c \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0639\u0645\u0648\u062f 40 0C\u00a0\u00a0<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c<\/strong>:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0642\u064f\u0633\u0645\u062a \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0625\u0644\u0649\u00a0 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0636\u0645\u062a \u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0639\u064a\u0651\u0646\u062a\u064a\u0646 \u0648\u0644\u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0639\u064a\u0651\u0646\u0629 \u0634\u0627\u0647\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u00a0\u062a\u0645 \u062d\u0633\u0627\u0628:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u062a\u0648\u0633\u0637 MEAN<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u062e\u0637\u0623 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0644\u0645\u062a\u0648\u0633\u0637SEM<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a SD<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">T-test<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u062c\u0631\u064a\u062a \u0627\u0644\u062d\u0633\u0627\u0628\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u062d\u0632\u0645 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0627\u062c\u062a\u0645\u0627\u0639\u064a\u0629 SPSS \u060c \u0627\u0644\u0625\u0635\u0640\u0640\u0640\u0640\u0640\u0640\u0640\u0640\u062f\u0627\u0631 25. \u0639\u0644\u0649 \u0627\u0639\u062a\u0628\u0627\u0631 \u0642\u064a\u0645\u0640\u0640\u0640\u0640\u0640\u0640\u0629 p \u0627\u0644\u0645\u0639\u062a\u062f\u0629 \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627 \u0647\u064a:p\u00a0 &lt;0.05 \u060c \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u03b1=0.05 \u060c \u0648\u0647\u064a \u062a\u0643\u0627\u0641\u0626 \u0645\u062c\u0627\u0644 \u0627\u0644\u0645\u0648\u062b\u0648\u0642\u064a\u0629 confidence interval %95. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (1) \u0639\u0645\u0631 \u0648\u062c\u0646\u0633 \u0627\u0644\u0645\u0631\u0636\u0649\u060c \u0648\u062f\u0631\u062c\u0629 \u0627\u0644\u0648\u0631\u0645\u060c \u0648\u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-642 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-10-e1699207684459-300x244.png\" alt=\"\" width=\"433\" height=\"352\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-10-e1699207684459-300x244.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-10-e1699207684459-1024x833.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-10-e1699207684459-768x625.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-10-e1699207684459-1536x1250.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-10-e1699207684459-2048x1666.png 2048w\" sizes=\"auto, (max-width: 433px) 100vw, 433px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0648\u062d\u0638 \u0623\u0646 \u0646\u0633\u0628\u0629 \u062a\u0648\u0632\u0639 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0628\u064a\u0646 \u0627\u0644\u0630\u0643\u0631 \u0648\u0627\u0644\u0623\u0646\u062b\u0649 \u0645\u062a\u0633\u0627\u0648\u064a\u0629\u060c \u0643\u0645\u0627 \u064a\u064f\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (2).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-643\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-11-300x59.png\" alt=\"\" width=\"458\" height=\"90\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-11-300x59.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-11-1024x200.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-11-768x150.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-11-1536x301.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-11-2048x401.png 2048w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u062c\u062f\u0648\u0644 (3) \u064a\u064f\u0648\u0636\u062d \u062a\u0631\u0643\u064a\u0632 (\u0645\u062a\u064a\u0644\u060c \u0625\u064a\u062a\u064a\u0644 \u0648\u0628\u0631\u0648\u0628\u064a\u0644) \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u0641\u064a \u0627\u0644\u0634\u0627\u0647\u062f\u060c \u0648\u0627\u0644\u0642\u064a\u0645 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645\u062b\u0644 (\u0637\u0631\u062d \u0627\u0644\u0634\u0627\u0647\u062f \u0645\u0646 \u0627\u0644\u0639\u064a\u0651\u0646\u0629) (\u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u063a\u0631\u0627\u0645).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u062d\u062a\u0648\u062a \u0628\u0639\u0636 \u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0634\u0627\u0647\u062f \u0639\u0644\u0649 \u0643\u0645\u064a\u0627\u062a \u0635\u063a\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u063a\u064a\u0631 \u0627\u0644\u0645\u0628\u0631\u0631\u0629\u060c \u0642\u062f \u064a\u0639\u0648\u062f \u0648\u062c\u0648\u062f \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0634\u0627\u0647\u062f \u0625\u0644\u0649 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u0631\u0627\u062c \u0646\u0641\u0633\u0647\u0627 [8] [18].<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-644\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-12-300x153.png\" alt=\"\" width=\"488\" height=\"249\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-12-300x153.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-12-1024x523.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-12-768x393.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-12-1536x785.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-12-2048x1047.png 2048w\" sizes=\"auto, (max-width: 488px) 100vw, 488px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u064f\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 (4) \u0627\u0644\u062d\u062f \u0627\u0644\u0623\u0639\u0644\u0649 \u0644\u062a\u0631\u0643\u064a\u0632 (\u0645\u062a\u064a\u0644\u060c \u0625\u064a\u062a\u064a\u0644 \u0648\u0628\u0631\u0648\u0628\u064a\u0644) \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0639\u064a\u0651\u0646\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633\u060c \u0643\u0645\u0627 \u064a\u064f\u0648\u0636\u062d\u00a0 \u0627\u0644\u062c\u062f\u0648\u0644 (5) \u0648\u0627\u0644\u0634\u0643\u0644 (2) \u0623\u0646 \u0645\u062a\u0648\u0633\u0637 \u062a\u0631\u0643\u064a\u0632 \u0625\u064a\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0647\u0648 \u0627\u0644\u0623\u0639\u0644\u0649 \u0641\u064a \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a (\u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u063a\u0631\u0627\u0645)\u060c \u064a\u0644\u064a\u0647 \u0645\u062a\u064a\u0644 \u062b\u0645 \u0628\u0631\u0648\u0628\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-645 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-13-e1699207974744-300x128.png\" alt=\"\" width=\"513\" height=\"219\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-13-e1699207974744-300x128.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-13-e1699207974744-1024x436.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-13-e1699207974744-768x327.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-13-e1699207974744-1536x654.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-13-e1699207974744.png 1754w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-646\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-14-300x83.png\" alt=\"\" width=\"528\" height=\"146\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-14-300x83.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-14-1024x282.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-14-768x212.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-14-1536x423.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-14-2048x564.png 2048w\" sizes=\"auto, (max-width: 528px) 100vw, 528px\" \/><\/span><\/p>\n<figure id=\"attachment_647\" aria-describedby=\"caption-attachment-647\" style=\"width: 489px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-647\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-15-300x168.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 2. \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633\" width=\"489\" height=\"274\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-15-300x168.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-15.png 721w\" sizes=\"auto, (max-width: 489px) 100vw, 489px\" \/><figcaption id=\"caption-attachment-647\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 2. \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 (6) \u0641\u0625\u0646 \u0645\u062a\u0648\u0633\u0637 \u0645\u062a\u064a\u0644\u060c \u0625\u064a\u062a\u064a\u0644\u060c \u0628\u0631\u0648\u0628\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u0645\u062a\u0648\u0633\u0637 \u0645\u062c\u0645\u0648\u0639 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 P=0.0001&lt;0.05)) \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0648\u0627\u0636\u062d\u0629 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062f\u0644\u0627\u0644\u0629 0.05 .<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-648\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-16-300x132.png\" alt=\"\" width=\"532\" height=\"234\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-16-300x132.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-16-1024x451.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-16-768x338.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-16-1536x677.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-16-2048x902.png 2048w\" sizes=\"auto, (max-width: 532px) 100vw, 532px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629<\/strong>:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u0639\u0645\u0631 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0643\u0648\u0631 \u0648\u0627\u0644\u0625\u0646\u0627\u062b 58 \u0639\u0627\u0645\u0627\u064b \u0639\u0644\u0649 \u062d\u062f \u0633\u0648\u0627\u0621\u060c \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0646 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u062a (ACS) \u062c\u0645\u0639\u064a\u0629 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0639\u0627\u0645 2019 \u0627\u0644\u062a\u064a \u062a\u0624\u0643\u062f \u0623\u0646\u0651 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u063a\u0627\u0644\u0628\u0627\u064b \u0645\u0627 \u062a\u0643\u0648\u0646 \u0641\u0648\u0642 \u0639\u0645\u0631 \u0627\u064445.[18]<\/span><\/li>\n<\/ul>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u062d\u062a\u0648\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0645\u0646 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0628\u0642\u064a\u0645\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 (318.8\u00b13.3) \u0646\u063a\/\u063a\u060c \u0645\u0639 \u0648\u062c\u0648\u062f \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0648\u0627\u0636\u062d\u0629 \u062a\u0631\u0628\u0637 \u0628\u064a\u0646 \u0648\u062c\u0648\u062f \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u0628\u064a\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633\u060c \u0648\u0628\u0645\u0627 \u0623\u0646 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u062a\u0623\u062b\u064a\u0631\u0627\u064b \u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u064a\u0627\u064b \u0648\u0641\u0642\u0627\u064b \u0644 Darbre PD \u0648\u0632\u0645\u0644\u0627\u0626\u0647 2004 [8] \u060c \u0648\u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0643\u062f\u0631\u0627\u0633\u0629 Konduri S \u0648\u0632\u0645\u0644\u0627\u0626\u0647 2012 \u0627\u0644\u062a\u064a \u062a\u0642\u062a\u0631\u062d \u0628\u0623\u0646 \u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u062f\u0648\u0631\u0627\u064b \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0627\u0644\u0628\u0634\u0631\u064a \u0646\u0638\u0631\u0627\u064b \u0644\u0648\u062c\u0648\u062f \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 [9] \u060c \u0641\u0639\u0644\u064a\u0647 \u0646\u0642\u062a\u0631\u062d \u0623\u0646\u0647 \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u062f\u0648\u0631 \u0641\u064a \u062a\u0637\u0648\u0631 \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0646\u0638\u0631\u0627\u064b \u0644\u062a\u0623\u062b\u064a\u0631\u0647 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u064a.<\/span><\/li>\n<\/ul>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0627\u0646 \u062a\u0631\u0643\u064a\u0632 \u0625\u064a\u062a\u064a\u0644 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0647\u0648 \u0627\u0644\u0623\u0639\u0644\u0649 \u0641\u064a \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 (112.9\u00b11.6) \u0646\u063a\/\u063a \u060c \u064a\u0644\u064a\u0647 \u0627\u0644\u0645\u062a\u064a\u0644 \u0628\u0627\u0631\u0627\u0628\u064a\u0646 (112.5\u00b11.4) \u0646\u063a\/\u063a\u060c \u0648 \u0623\u062e\u064a\u0631\u0627\u064b \u0627\u0644\u0628\u0631\u0648\u0628\u064a\u0644 \u0628\u0627\u0631\u0627\u0628\u064a\u0646 (93.4\u00b11.8) \u0646\u063a\/\u063a\u060c \u0644\u0627 \u062a\u0648\u062c\u062f \u062f\u0631\u0627\u0633\u0627\u062a \u062d\u0627\u0644\u064a\u0629 \u062a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0648\u062a\u0631\u0643\u064a\u0632\u0647 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633.<\/span><\/li>\n<\/ul>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0645\u064a\u0639 \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0647\u064a \u0623\u0648\u0631\u0627\u0645 \u0645\u0646 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629\u060c \u0643\u0645\u0627 \u062a\u0633\u0627\u0648\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u064a\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0648\u0627\u0644\u0625\u0646\u0627\u062b \u062d\u064a\u062b \u0628\u0644\u063a\u062a 50% \u0644\u0643\u0644 \u0645\u0646\u0647\u0645\u0627\u060c \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u062a (ACS) \u062c\u0645\u0639\u064a\u0629 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0639\u0627\u0645 2019. [19]<\/span><\/li>\n<\/ul>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0627\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0631\u0636\u0649 \u0633\u0643\u0631\u064a\u060c \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 Li D \u0641\u064a \u0639\u0627\u0645 2012 \u0627\u0644\u062a\u064a \u062a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u062a\u0631\u062a\u0641\u0639 \u0628\u064a\u0646 \u0645\u0631\u0636\u0649 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0631\u064a\u060c \u0648\u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647\u0630\u0627 \u0639\u0644\u0627\u0642\u0629 \u0628\u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0633\u0643\u0631 \u0627\u0644\u062f\u0645 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0634\u062f\u0629 \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0629 \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 [19][20] \u060c \u0648\u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u062a\u0623\u062b\u064a\u0631 \u0641\u064a \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646\u060c \u062e\u0635\u0648\u0635\u0627\u064b \u0644\u0627\u062d\u062a\u0648\u0627\u0621 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0639\u0644\u0649 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0625\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a<\/strong>:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u064f\u062b\u0631 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0641\u064a \u062c\u0645\u0628\u0639 \u0639\u064a\u0646\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0628\u062a\u0631\u0627\u0643\u064a\u0632 \u0639\u0627\u0644\u064a\u0629 \u062c\u062f\u064b\u0627 \u060c \u062d\u064a\u062b \u064a\u062d\u062a\u0648\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0639\u0644\u0649 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u060c \u0644\u0630\u0644\u0643 \u0642\u062f \u064a\u0624\u062f\u0651\u064a \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u062f\u0648\u0631\u064b\u0627 \u0641\u064a \u0632\u064a\u0627\u062f\u0629 \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u0627\u0644\u062d\u062b \u0639\u0644\u0649 \u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u063a\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0644\u062a\u0634\u0643\u064a\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0630\u0644\u0643 \u0646\u0642\u062a\u0631\u062d \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0644\u0645\u0639\u0631\u0641\u0629 \u0645\u062f\u0649 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0639\u0644\u0649 \u062e\u0644\u0627\u064a\u0627\u0647\u060c \u0648\u0645\u0627 \u0627\u0630\u0627 \u0643\u0627\u0646 \u0644\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0623\u064a\u00a0 \u062e\u0627\u0635\u064a\u0629 \u062a\u0631\u0627\u0643\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0645\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u062a\u064a \u064a\u062a\u0639\u0631\u0636 \u0644\u0647\u0627 \u0627\u0644\u0625\u0646\u0633\u0627\u0646\u060c \u0648\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0644\u062a\u0631\u0627\u0643\u0645\u0647\u0627 \u0623\u064a \u062a\u0623\u062b\u064a\u0631 \u0645\u062d\u0641\u0632 \u0644\u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u062a\u0643\u0627\u062b\u0631\u0627\u064b \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a\u060c \u0648\u062a\u062d\u0631\u064a\u0636 \u062a\u0634\u0643\u0644 \u0627\u0644\u0623\u0648\u0631\u0627\u0645.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u0639\u064f\u0631\u0641 \u0627\u0644\u0628\u0627\u0631\u0627\u0628\u064a\u0646 \u0645\u0646 \u0642\u0628\u0644 \u062b\u064a\u0648\u062f\u0648\u0631 \u0633\u0627\u0628\u0627\u0644\u064a\u062a\u0634\u0643\u0627 \u0641\u064a \u0639\u0627\u0645 1920\u060c \u0648\u0645\u0646\u0630 \u0630\u0644\u0643 \u0627\u0644\u062d\u064a\u0646\u060c \u0627\u0633\u062a\u062e\u062f\u0645 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0639\u0644\u0649 \u0623\u0646\u0651\u0647 \u0645\u0627\u062f\u0651\u0629 \u062d\u0627\u0641\u0638\u0629&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=207\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":1,"featured_media":647,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-132","volume-8"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=207"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/207\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/647"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}