{"id":2095,"date":"2025-08-23T08:19:32","date_gmt":"2025-08-23T08:19:32","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2095"},"modified":"2025-08-23T08:19:32","modified_gmt":"2025-08-23T08:19:32","slug":"%d8%a7%d9%84%d8%aa%d8%b9%d8%af%d8%af-%d8%a7%d9%84%d8%b4%d9%83%d9%84%d9%8a-%d9%88%d8%ad%d9%8a%d8%af-%d8%a7%d9%84%d9%86%d9%88%d9%83%d9%84%d9%8a%d9%88%d8%aa%d9%8a%d8%af-rs6166-c-t-%d9%81%d9%8a-%d8%ac","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2095","title":{"rendered":"\u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0648\u062d\u064a\u062f \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f rs6166 C\/T \u0641\u064a \u062c\u064a\u0646 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u0646\u0628\u0651\u0647 \u0644\u0644\u062c\u0631\u064a\u0628 \u0644\u062f\u0649 \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0627\u0644\u0633\u0651\u0648\u0631\u064a\u0627\u062a \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u062d\u0627\u0644\u0629-\u0634\u0627\u0647\u062f"},"content":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 <\/strong>Introduction<\/strong><\/p>\n

\u062a\u064f\u0639\u064e\u062f\u0651 \u0645\u062a\u0644\u0627\u0632\u0645\u0629\u064f \u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a (PCOS) Polycystic Ovary Syndrome \u062d\u0627\u0644\u0629\u064b \u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629\u064b \u0634\u0627\u0626\u0639\u0629\u064b \u062a\u0635\u064a\u0628\u064f \u0627\u0644\u0646\u0651\u0633\u0627\u0621 \u0641\u064a \u0633\u0646\u0651 \u0627\u0644\u0625\u0646\u062c\u0627\u0628 \u0628\u0646\u0633\u0628\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 8%- 13% \u062d\u0633\u0628 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u062a \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0627\u0644\u0635\u0627\u062f\u0631\u0629 \u0639\u0627\u0645 2023 (1).<\/p>\n

\u0648\u062a\u0634\u064a\u0631\u064f \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0623\u0633\u0627\u0633 \u0648\u0631\u0627\u062b\u064a \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0648\u0630\u0644\u0643 \u0646\u0638\u0631\u0627\u064b \u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u064a\u0646 \u0627\u0644\u0625\u0646\u0627\u062b \u0627\u0644\u0644\u0648\u0627\u062a\u064a \u062a\u0631\u0628\u0637\u0647\u0646 \u0635\u0644\u0627\u062a \u0642\u0631\u0628\u0649 (PCOS) \u00a0(2)\u060c \u0648\u0631\u063a\u0645 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629\u060c \u0641\u0644\u0627 \u062a\u0632\u0627\u0644 \u0627\u0644\u0645\u0633\u0628\u0628\u0627\u062a \u0642\u064a\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0646 \u0627\u0644\u0646\u0627\u062d\u064a\u0629 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0629 \u0648\u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0648\u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0628\u064a\u0626\u0629 \u0627\u0644\u0645\u062d\u064a\u0637\u0629 \u0648\u062a\u0623\u062b\u064a\u0631\u0647\u0627 (3\u20135)\u060c \u062d\u064a\u062b \u064a\u0624\u0643\u0651\u062f\u064f \u0627\u0644\u062a\u0651\u063a\u0627\u064a\u0631 \u0623\u0648 \u0639\u062f\u0645 \u0627\u0644\u062a\u0651\u062c\u0627\u0646\u0633 heterogeneity \u0627\u0644\u0625\u062b\u0646\u064a ethnic \u0648\u0627\u0644\u062c\u063a\u0631\u0627\u0641\u064a geographic \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0623\u0646\u0651 \u0647\u0630\u0627 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628 \u0645\u0631\u062a\u0628\u0637 \u0628\u0639\u0648\u0627\u0645\u0644 \u0628\u064a\u0626\u064a\u0629\u060c \u0643\u0645\u0627 \u062a\u0642\u062a\u0631\u062d \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u062a\u062d\u0631\u0651\u064a \u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a(6)\u060c \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u0639\u0642\u0651\u062f\u0629 \u0648\u062a\u0646\u0637\u0648\u064a \u0639\u0644\u0649 \u0633\u0628\u0644\u064d \u0648\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 (7)\u060c \u0648\u0627\u0642\u062a\u0631\u062d\u062a \u062f\u0631\u0627\u0633\u0627\u062a\u064c \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0648\u0627\u0633\u0639 \u0644\u0644\u0645\u062c\u064a\u0646 Genome-wide association studies (GWAS) \u0648\u062c\u0648\u062f\u064e \u062f\u0644\u0627\u0626\u0644\u064d \u0642\u0648\u064a\u0629 \u0639\u0644\u0649 \u0623\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644\u064e \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u062a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0645\u0647\u0645\u0651\u0627\u064b \u0641\u064a \u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a(3)\u060c \u062d\u064a\u062b\u064f \u062a\u064f\u0634\u064a\u0631\u064f \u0627\u0644\u062a\u0651\u0642\u062f\u064a\u0631\u0627\u062a\u064f \u0625\u0644\u0649 \u0623\u0646\u0651 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u062a\u0633\u0627\u0647\u0645 \u0628\u0646\u0633\u0628\u0629 79% \u0641\u064a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629\u060c \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0628\u064a\u0626\u064a\u0651\u0629 \u0648\u0623\u0633\u0644\u0648\u0628 \u0627\u0644\u062d\u064a\u0627\u0629 \u064a\u0633\u0627\u0647\u0645 \u0628\u0646\u0633\u0628\u0629 21% \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f\u0627\u062a \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 (8).<\/p>\n

\u0637\u064f\u0628\u0651\u0642\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0648\u0627\u0633\u0639 \u0644\u0644\u0645\u062c\u064a\u0646 \u0644\u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064f\u0624\u064e\u0647\u0651\u0650\u0628\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u062f\u0649 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0622\u0633\u064a\u0648\u064a\u0627\u062a \u0648\u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0627\u062a\u060c \u0648\u062a\u0628\u064a\u0651\u0646 \u0623\u0646\u0651 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0634\u062a\u0628\u0647 \u0628\u0645\u0633\u0627\u0647\u0645\u062a\u0647\u0627 \u0641\u064a \u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u062a\u0634\u0645\u0644 \u0643\u0644\u0651\u0627\u064b \u0645\u0646: \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u064f\u0646\u0628\u0651\u0647 \u0644\u0644\u062c\u0631\u064a\u0628 Follicle Stimulating Hormone Receptor (FSHR)\u060c \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0625\u0646\u0633\u0648\u0644\u064a\u0646 Insulin Receptor (INSR)\u060c \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0645\u0648\u0644\u0631 Anti-Mullerian Hormone (AMH)\u060c \u0645\u064f\u0633\u062a\u064e\u0642\u0628\u0650\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u064f\u0644\u064e\u0648\u062a\u0650\u0646\/ \u0645\u064f\u0648\u064e\u062c\u0651\u0650\u0647\u064e\u0629\u064f \u0627\u0644\u063a\u064f\u062f\u064e\u062f\u0650 \u0627\u0644\u062a\u0651\u064e\u0646\u064e\u0627\u0633\u064f\u0644\u0650\u064a\u0651\u064e\u0629\u0650 \u0627\u0644\u0645\u064e\u0634\u064a\u0645\u0627\u0626\u0650\u064a\u0651\u064e\u0629 Luteinizing Hormone\/Choriogonadotropin Receptor (LHCGR) (7,9).<\/p>\n

\u062a\u062a\u0635\u0641 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u0642\u0644\u0629\/\u0627\u0646\u0639\u062f\u0627\u0645 \u0627\u0644\u0625\u0628\u0627\u0636\u0629oligo\/anovulation \u00a0\u0648\u0641\u0631\u0637 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0651\u0629 hyperandrogenism \u0648\u062a\u064f\u0639\u062f \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0634\u0639\u0631\u0627\u0646\u064a\u0629 hirsutism \u0648\u062d\u062f\u0647\u0627 \u0645\u0624\u0634\u0631\u0627\u064b \u062a\u0646\u0628\u0624\u064a\u0651\u0627\u064b \u0644\u0641\u0631\u0637 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0651\u0629 \u0648\u0639\u062f\u0645 \u0627\u0646\u062a\u0638\u0627\u0645 \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u0634\u0647\u0631\u064a\u0629 menstrual irregularities (10)\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062d\u064e\u0628\u0651\u064f \u0627\u0644\u0634\u0651\u064e\u0628\u0627\u0628 \u0623\u0648 \u0627\u0644\u0639\u062f\u0651 acne \u0648\u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0625\u0646\u0633\u0648\u0644\u064a\u0646 insulin resistance. \u0623\u0645\u0651\u0627 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0623\u0645\u062f \u0644\u0640 PCOS \u0641\u062a\u0634\u0645\u0644 \u0643\u0644\u0627\u064b \u0645\u0646: \u0627\u0644\u0639\u0642\u0645 \u0627\u0644\u0645\u064f\u0633\u064e\u0628\u0651\u0628 \u0628\u0627\u0646\u0639\u062f\u0627\u0645 \u0627\u0644\u0625\u0628\u0627\u0636\u0629 anovulatory infertility (11)\u060c \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628\u064a\u0629 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 cardiovascular diseases \u0648\u0627\u0644\u0628\u062f\u0627\u0646\u0629 obesity \u0648\u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0631\u064a \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062b\u0627\u0646\u064a type2 diabetes (12).<\/p>\n

\u064a\u0639\u062f \u0627\u0644\u0639\u0642\u0645 \u0623\u062d\u062f \u0623\u0647\u0645 \u0648\u0623\u0628\u0631\u0632 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u0635\u062d\u064a\u0629 \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a (11)\u060c \u0648\u064a\u0639\u062f\u0651 \u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0625\u0628\u0627\u0636\u0629 ovulation disorders \u0623\u062d\u062f \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u064f\u0633\u0628\u0628\u0629 \u0648\u064a\u0646\u062c\u0645 \u0639\u0646 \u0627\u062e\u062a\u0644\u0627\u0644 \u062a\u0648\u0627\u0632\u0646 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a\u060c \u062d\u064a\u062b \u0623\u0646\u0651 \u0644\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u062c\u0646\u0633\u064a\u0629 \u0648\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u0647\u0627 \u062f\u0648\u0631\u0627\u064b \u0623\u0633\u0627\u0633\u064a\u0627\u064b \u0641\u064a \u062a\u0643\u0648\u0651\u0646 \u0627\u0644\u062c\u0631\u064a\u0628\u0627\u062a folliculogenesis (13)\u060c \u0648\u062a\u0624\u062b\u0631 \u0632\u064a\u0627\u062f\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646\u0627\u062a \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0633\u0644\u0628\u0627\u064b \u0641\u064a \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0625\u0628\u0627\u0636\u0629\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0625\u0646\u0633\u0648\u0644\u064a\u0646 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0647\u0645 \u0641\u064a \u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0625\u0628\u0627\u0636\u0629 (14).<\/p>\n

\u064a\u0631\u062a\u0628\u0637 \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u0646\u0628\u0647 \u0644\u0644\u062c\u0631\u064a\u0628 \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0647 \u0644\u064a\u064f\u062d\u064e\u0631\u0651\u0650\u0636 \u0646\u0645\u0648 \u0627\u0644\u0628\u0648\u064a\u0636\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u0628\u064a\u0636\u060c \u0648\u062a\u0637\u0648\u0651\u0631 \u0627\u0644\u062c\u064f\u0631\u064a\u0628\u0627\u062a \u0639\u0646\u062f \u0627\u0644\u0625\u0646\u0627\u062b\u060c \u0648\u0644\u0647 \u062f\u0648\u0631 \u062d\u0627\u0633\u0645 \u0641\u064a \u062a\u0646\u0638\u064a\u0645 \u0627\u0644\u0646\u0645\u0648 \u0648\u0627\u0644\u062a\u0637\u0648\u0631 \u0627\u0644\u062c\u0646\u0633\u064a \u0648\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u0644\u062f\u0649 \u0627\u0644\u0630\u0643\u0648\u0631 \u0648\u0627\u0644\u0625\u0646\u0627\u062b (15,16). \u064a\u062a\u0648\u0636\u0651\u0639 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a rs6166 C\/T, Ser680Asn \u00a0\u00a0\u0636\u0645\u0646 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u0639\u0627\u0634\u0631 \u0645\u0646 \u062c\u064a\u0646 FSHR<\/em> \u0648\u064a\u0624\u062f\u064a <\/em>\u0648\u062c\u0648\u062f \u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f C \u0641\u064a \u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0651\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0625\u0644\u0649 \u062a\u0631\u0645\u064a\u0632 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a \u0633\u064a\u0631\u064a\u0646 Serine\u060c \u0648\u0627\u0644\u0646\u064a\u0643\u0644\u064a\u0648\u062a\u064a\u062f T \u064a\u0631\u0645\u0651\u0632 \u0644\u0644\u062d\u0645\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a \u0623\u0633\u0628\u0627\u0631\u062c\u064a\u0646 Asparagine \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 680 \u0641\u064a \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u0646\u0628\u0647 \u0644\u0644\u062c\u0631\u064a\u0628 \u0642\u0631\u0628 \u0627\u0644\u0646\u0651\u0647\u0627\u064a\u0629 \u0627\u0644\u0643\u0631\u0628\u0648\u0643\u0633\u064a\u0644\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0648\u064a\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647 \u0623\u062b\u0631 \u0641\u064a \u0646\u0642\u0644 \u0627\u0644\u0634\u0627\u0631\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 (17).<\/p>\n

 <\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f\u0651 \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong>Materials and methods<\/strong><\/p>\n

\u0635\u0645\u0645\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0623\u0646 \u062a\u0643\u0648\u0646 \u062f\u0631\u0627\u0633\u0629 \u0631\u0635\u062f\u064a\u0629 \u0645\u0646 \u0646\u0645\u0637 \u062d\u0627\u0644\u0629-\u0634\u0627\u0647\u062f observational case-control study\u060c \u0645\u0634\u062a\u0645\u0644\u0629 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0633\u064a\u062f\u0627\u062a \u0627\u0644\u0628\u0627\u0644\u063a\u0627\u062a \u0645\u0645\u0646 \u0644\u0645 \u064a\u062a\u062c\u0627\u0648\u0632\u0646 \u0633\u0646 \u0627\u0644\u0625\u064a\u0627\u0633.<\/p>\n

\u0635\u0646\u0641\u062a \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0627\u062a \u0636\u0645\u0646 \u0630\u0631\u0627\u0639\u064a\u0646\u061b \u0630\u0631\u0627\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 case \u064a\u0634\u0645\u0644 38 \u0645\u0631\u064a\u0636\u0629\u060c \u0648\u0643\u0627\u0646\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0634\u062a\u0645\u0627\u0644: \u0627\u0644\u062a\u0651\u0634\u062e\u064a\u0635 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u062d\u0633\u0628 \u0645\u0639\u0627\u064a\u064a\u0631 \u0631\u0648\u062a\u0631\u062f\u0627\u0645\u060c \u0648\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f: \u062c\u0645\u064a\u0639 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0623\u0646\u062b\u0648\u064a\u060c \u0641\u0631\u0637 \u062a\u0646\u0633\u062c \u0627\u0644\u0643\u0638\u0631\u060c \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0627\u0644\u0646\u0634\u0637\u0629\u060c \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0643\u0648\u0634\u064a\u0646\u063a\u060c \u062c\u0645\u064a\u0639 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u062a\u064a \u062a\u062a\u0636\u0645\u0646 \u0623\u062c\u0632\u0627\u0621 \u0645\u0646 \u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0627\u0646\u062b\u0648\u064a. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0628\u0639\u0636 \u0627\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u064a \u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0634\u0648\u0627\u0647\u062f \u0645\u062b\u0644 \u0627\u0644\u062e\u0636\u0648\u0639 \u0644\u0639\u0644\u0627\u062c \u064a\u0624\u062b\u0631 \u0641\u064a \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u0643\u0631\u0628\u0648\u0647\u064a\u062f\u0631\u0627\u062a\u060c \u0623\u0648 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645\u060c \u0645\u0648\u0627\u0646\u0639 \u062d\u0645\u0644 \u0641\u0645\u0648\u064a\u0629\u060c \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062e\u0627\u0641\u0636\u0629 \u0644\u0644\u0634\u062d\u0648\u0645\u060c (\u064a\u062c\u0628 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0645\u062b\u0644 \u0647\u0630\u0647 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0642\u062f \u0623\u064f\u0648\u0642\u0641\u064e\u062a \u0642\u0628\u0644 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631 \u0645\u0646 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062f\u0631\u0627\u0633\u0629)\u060c \u0648\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u0648\u0641\u0631\u0637 \u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u062f\u0645.<\/p>\n

\u0630\u0631\u0627\u0639 \u0627\u0644\u0634\u0627\u0647\u062f control \u064a\u0636\u0645 46 \u0633\u064a\u062f\u0629 \u0630\u0627\u062a \u062f\u0648\u0631\u0629 \u0634\u0647\u0631\u064a\u0629 \u0645\u0646\u062a\u0638\u0645\u0629\u060c \u0645\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0637\u0628\u064a\u0639\u064a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646 \u0648\u0644\u064a\u0633 \u0644\u062f\u064a\u0647\u0645 \u0623\u064a \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a \u0644\u0644\u0634\u0639\u0631\u0627\u0646\u064a\u0629. \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0627\u0647\u062f\u0629 \u0645\u0645\u0627\u062b\u0644\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u0641\u0626\u0629 \u0627\u0644\u0639\u0645\u0631\u064a\u0629 (18-45 \u0633\u0646\u0629).<\/p>\n

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\"\"<\/p>\n

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\u062d\u064f\u0636\u0646\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u062f\u0629 180 \u062f\u0642\u064a\u0642\u0629 \u0641\u064a \u062d\u0645\u0651\u0627\u0645 \u0645\u0627\u0626\u064a \u0628\u062f\u0631\u062c\u062965 \u00a0C\u00b0 \u062b\u0645\u0651 \u0631\u064f\u062d\u0651\u0644\u064e\u062a \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0642\u0637\u0639 \u0644\u0644\u062d\u062c\u0645 \u0643\u0627\u0645\u0644\u0627\u064b \u0645\u0639 \u0635\u0628\u063a\u0629 \u0627\u0644\u062a\u062d\u0645\u064a\u0644 6X \u0628\u0646\u0633\u0628\u0629 5:1 \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0623\u063a\u0627\u0631\u0648\u0632 \u0628\u062a\u0631\u0643\u064a\u0632 4%\u060c \u0628\u0641\u0648\u0644\u062a\u064a\u0651\u0629 50 \u0648\u0644\u0645\u062f\u0629 30 \u062f\u0642\u064a\u0642\u0629.<\/p>\n

\u0623\u064f\u062c\u0631\u064a\u064e \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c R \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a \u0648\u0628\u0631\u0646\u0627\u0645\u062c GraphPad Prism (version 8.0.1) \u062a\u0645\u062a \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 Chi-square \u00a0\u0644\u0645\u0639\u0631\u0641\u0629 \u0641\u064a\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u064a\u064f\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P-value< 0.05) \u0623\u0648 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0627\u0644\u0645\u0635\u0627\u062f\u0641\u0629 (P-value> 0.05).<\/p>\n

\u00a0<\/strong><\/p>\n

\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong>Results<\/strong><\/p>\n

\u0638\u0647\u0631\u062a \u0628\u0646\u062a\u064a\u062c\u0629 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u0631\u0627\u0632 \u0627\u0644\u062a\u0651\u0633\u0644\u0633\u0644\u064a \u0634\u062f\u0641\u0629 \u0648\u062d\u064a\u062f\u0629 \u0628\u0637\u0648\u0644 \u064a\u0642\u0627\u0631\u0628 114 \u0632\u0648\u062c \u0623\u0633\u0627\u0633\u060c \u0648\u064a\u0645\u0643\u0646 \u0631\u0624\u064a\u0629 \u0645\u062b\u0627\u0644 \u0644\u062a\u0631\u062d\u064a\u0644 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644PCR \u0644\u0633\u062a\u0651 \u0639\u064a\u0646\u0627\u062a (\u0627\u0644\u0634\u0643\u0644 1).<\/p>\n

\"\"<\/p>\n

 <\/p>\n

\u064a\u0638\u0647\u0631 \u0644\u062f\u0649 \u062a\u0637\u0628\u064a\u0642 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0647\u0636\u0645 \u0627\u0644\u0623\u0646\u0632\u064a\u0645\u064a \u0628\u0623\u0646\u0632\u064a\u0645 BsrI \u0639\u0644\u0649 \u0645\u0646\u062a\u062c PCR \u0639\u0635\u0627\u0628\u062a\u0627\u0646 \u0628\u0623\u0637\u0648\u0627\u0644 86 \u064828 \u0632\u0648\u062c \u0623\u0633\u0627\u0633\u060c \u0646\u0638\u0631\u0627\u064b \u0644\u0627\u062d\u062a\u0648\u0627\u0621 \u0627\u0644\u0634\u062f\u0641\u0629 \u0644\u0645\u0648\u0642\u0639 \u0642\u0637\u0639 \u0648\u0627\u062d\u062f \u0641\u0642\u0637 \u0641\u064a \u062d\u0627\u0644 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0633\u0627\u0633 C \u0641\u064a \u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0651\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a. \u0641\u064a \u062d\u0627\u0644\u0629 \u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a Homozygotic CC \u0641\u062a\u0643\u0648\u0646 \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0642\u0637\u0639 \u0638\u0647\u0648\u0631 \u0639\u0635\u0627\u0628\u062a\u064a\u0646 \u0628\u0623\u0637\u0648\u0627\u0644 86 \u0648 28 \u0632\u0648\u062c \u0623\u0633\u0627\u0633\u060c \u0648\u0639\u0635\u0627\u0628\u0629 \u0648\u0627\u062d\u062f\u0629 \u0628\u0637\u0648\u0644 \u0645\u0646\u062a\u062c \u0627\u0644\u0640PCR 114 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 \u0641\u064a \u062d\u0627\u0644 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0633\u0627\u0633 T \u0641\u064a \u0645\u0648\u0642\u0639 \u0627\u0644\u062a\u0651\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0641\u064a \u0627\u0644\u0623\u0644\u064a\u0644\u064a\u0646 \u062d\u064a\u062b \u064a\u063a\u064a\u0628 \u0645\u0648\u0642\u0639 \u0627\u0644\u0642\u0637\u0639 (\u062d\u0627\u0644\u0629 \u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a Homozygotic TT)\u060c \u0623\u0645\u0627 \u0641\u064a \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a Heterozygotic CT \u0641\u062a\u0643\u0648\u0646 \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0642\u0637\u0639 \u0638\u0647\u0648\u0631 \u062b\u0644\u0627\u062b \u0634\u062f\u0641 \u0628\u0623\u0637\u0648\u0627\u0644 114\u060c 86 \u064828 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 \u0648\u064a\u0645\u0643\u0646 \u0631\u0624\u064a\u0629 \u0645\u062b\u0627\u0644 \u0644\u062a\u0631\u062d\u064a\u0644 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0647\u0636\u0645 \u0644\u0625\u062d\u062f\u0649 \u0639\u0634\u0631\u0629 \u0639\u064a\u0646\u0629 (\u0627\u0644\u0634\u0643\u0644 2).<\/p>\n

\"\"<\/p>\n

\u062a\u064f\u0628\u064a\u0651\u0646 \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0623\u0646\u0651 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u0632\u064a\u062c\u0648\u062a CT \u0627\u0644\u0623\u0643\u062b\u0631 \u062a\u0648\u0627\u062a\u0631\u0627\u064b \u0628\u0646\u0633\u0628\u0629 65.79 % \u0648\u0642\u0627\u0628\u0644\u062a\u0647\u0627 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0646\u0633\u0628\u0629 43.48%\u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0645\u062a\u0645\u0627\u062b\u0644\u0629 \u0627\u0644\u0632\u064a\u062c\u0648\u062a CC \u0648TT \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0636\u0649 10.53 \u064823.68 \u0639\u0644\u0649 \u0627\u0644\u062a\u0651\u0631\u062a\u064a\u0628\u060c \u0648\u0639\u0646\u062f \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f 23.91 \u064832.61 \u0639\u0644\u0649 \u0627\u0644\u062a\u0651\u0631\u062a\u064a\u0628\u060c \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0641\u064a \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0628\u064a\u0646 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f (P=0.1). \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 C 43.42% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u064845.65% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f\u060c \u0623\u0645\u0651\u0627 \u0627\u0644\u0623\u0644\u064a\u0644 T \u0641\u0642\u062f \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631\u0647 56.58% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u064854.35% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0628\u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P=0.7)\u060c \u0643\u0645\u0627 \u064a\u0648\u0636\u0651\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (3).<\/p>\n

\"\"<\/p>\n

 <\/p>\n

\"\"<\/p>\n

 <\/p>\n

\"\"<\/p>\n

 <\/p>\n

 <\/p>\n

\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong>Discussion<\/strong><\/p>\n

\u062a\u0628\u062f\u064a \u0627\u0644\u062a\u0651\u063a\u0627\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u062a\u0628\u0627\u064a\u0646\u0627\u062a \u0634\u062f\u064a\u062f\u0629 \u0628\u064a\u0646 \u0627\u0644\u0623\u0639\u0631\u0627\u0642 \u0648\u0627\u0644\u0625\u062b\u0646\u064a\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u062a\u064f\u0639\u062f\u0651 \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u062a\u0639\u062f\u062f\u0627\u062a \u0627\u0644\u0634\u0651\u0643\u0644\u064a\u0629 \u0648\u0639\u0644\u0627\u0642\u062a\u0647\u0627 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0628\u064a\u0646 \u0627\u0644\u0623\u062b\u0646\u064a\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0636\u0631\u0648\u0631\u0629 \u0644\u0644\u062a\u0646\u0628\u0651\u0624 \u0628\u062d\u062f\u0648\u062b \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0625\u0645\u0643\u0627\u0646\u064a\u0651\u0629 \u062a\u062f\u0628\u064a\u0631\u0647\u0627 \u0628\u0627\u0644\u0634\u0651\u0643\u0644 \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0644\u0643\u0644 \u062c\u0645\u0647\u0631\u0629 \u0633\u0643\u0627\u0646\u064a\u0651\u0629.<\/p>\n

\u062a\u064f\u0628\u064a\u0651\u0646 \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0623\u0646\u0651 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0623\u0643\u062b\u0631 \u062a\u0648\u0627\u062a\u0631\u0627\u064b \u0647\u0648 \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u0632\u064a\u062c\u0648\u062a CT \u062f\u0648\u0646 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0641\u064a \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0628\u064a\u0646 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f (P=0.1). \u0627\u062a\u0651\u0641\u0642\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u0628\u0631\u062a\u063a\u0627\u0644 \u062d\u064a\u062b\u064f \u0644\u0645 \u064a\u0648\u062c\u062f \u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0648\u0628\u0644\u063a \u0639\u062f\u062f \u0627\u0644\u0639\u064a\u0646\u0627\u062a 80 \u062d\u0627\u0644\u0629 \u064880 \u0634\u0627\u0647\u062f (19). \u0648\u0627\u062a\u0641\u0642\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0623\u064a\u0636\u0627\u064b \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u0629 \u062d\u064a\u062b\u064f \u0644\u0645 \u064a\u0648\u062c\u062f \u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0648\u0628\u0644\u063a \u0639\u062f\u062f \u0627\u0644\u0639\u064a\u0646\u0627\u062a 96 \u062d\u0627\u0644\u0629 96 \u0634\u0627\u0647\u062f (20). \u0648\u0627\u062e\u062a\u0644\u0641\u062a \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0643\u0648\u0631\u064a\u0627 \u0627\u0644\u062c\u0646\u0648\u0628\u064a\u0629 \u062d\u064a\u062b\u064f \u0643\u0627\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 (P=0.035) \u0648\u0628\u0644\u063a \u0639\u062f\u062f \u0627\u0644\u0639\u064a\u0646\u0627\u062a 377 \u0645\u0631\u064a\u0636\u0629 PCOS \u0648388 \u0634\u0627\u0647\u062f (21).<\/p>\n

\u0644\u0645 \u064a\u064f\u0644\u0627\u062d\u0638 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0641\u064a \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0644\u064a\u0644 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f (P=0.7)\u060c \u062d\u064a\u062b\u064f \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 C 43.42% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u064845.65% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f\u060c \u0623\u0645\u0651\u0627 \u0627\u0644\u0623\u0644\u064a\u0644 T \u0641\u0642\u062f \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631\u0647 56.58% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u064854.35% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f. \u0627\u062a\u0641\u0642\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u0646 \u0627\u0644\u0634\u0651\u0645\u0627\u0644\u064a\u0629 (15)\u060c \u0648\u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u062a\u0631\u0643\u064a\u0627 (18)\u060c \u0648\u0627\u062e\u062a\u0644\u0641\u062a \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0647\u0646\u062f\u064a\u0629 (13).<\/p>\n

 <\/p>\n

\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong><\/p>\n

\u0644\u0627 \u062a\u062f\u0639\u0645 \u0646\u062a\u0627\u0626\u062c \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u062c\u0648\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a\u0651 rs6166 C\/T \u0641\u064a \u062c\u064a\u0646 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u0646\u0628\u0651\u0647 \u0644\u0644\u062c\u0631\u064a\u0628 \u0648\u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629.<\/p>\n

\u0627\u0644\u0645\u062d\u062f\u0648\u062f\u064a\u0651\u0627\u062a <\/strong>Limitation<\/strong>: <\/strong>\u062a\u0639\u0630\u0651\u0631 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646 \u0627\u0644\u0637\u0648\u0644 \u0648\u0627\u0644\u0648\u0632\u0646\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0635\u063a\u0631 \u062d\u062c\u0645 \u0627\u0644\u0639\u064a\u0646\u0629 \u0628\u0633\u0628\u0628 \u062a\u0643\u0644\u0641\u0629 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629.<\/p>\n

\u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a <\/strong>Recommendation<\/strong>:<\/strong> \u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a rs6166 C\/T \u0628\u0643\u0644 \u0645\u0639\u064a\u0627\u0631 \u0645\u0646 \u0645\u0639\u0627\u064a\u064a\u0631 \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a\u060c \u0648\u0639\u0644\u0627\u0642\u0629 \u0623\u0646\u0645\u0627\u0637\u0647 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0645\u0639 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0645\u0646\u0628\u0651\u0647 \u0627\u0644\u062c\u0631\u064a\u0628 \u0644\u0644\u062c\u0631\u064a\u0628.<\/p>\n

 <\/p>\n

\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a <\/strong>List of abbreviations<\/strong>:<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n
Follicle-stimulating hormone receptor<\/td>\nFSHR<\/td>\n<\/tr>\n
Polymerase chain reaction<\/td>\nPCR<\/td>\n<\/tr>\n
Polycystic ovary syndrome<\/td>\nPCOS<\/td>\n<\/tr>\n
Restriction fragment length polymorphism<\/td>\nRFLP<\/td>\n<\/tr>\n
Genome-wide association studies<\/td>\nGWAS<\/td>\n<\/tr>\n
Anti-M\u00fcllerian Hormone<\/td>\nAMH<\/td>\n<\/tr>\n
Luteinizing Hormone\/Choriogonadotropin Receptor<\/td>\nLHCGR<\/td>\n<\/tr>\n
Insulin Receptor<\/td>\nINSR<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 <\/strong>Ethics approval and consent to participate<\/strong><\/p>\n

\u062d\u0635\u0644\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a\u0651 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0628\u062a\u0627\u0631\u064a\u062e 24\/2\/2025\u060c \u0648\u0628\u0631\u0642\u0645 919.<\/p>\n

\u00a0<\/strong><\/p>\n

\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong>Conflict of interests<\/strong><\/p>\n

\u00a0<\/strong>\u064a\u0642\u0631 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n

\u00a0<\/strong><\/p>\n

\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong>Funding<\/strong><\/p>\n

\u062a\u0645 \u062a\u0645\u0648\u064a\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u0642\u0650\u0628\u064e\u0644 \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/p>\n

\u00a0<\/strong><\/p>\n

\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong>\u00a0contributions<\/strong>\u2019<\/strong>Authors<\/strong><\/p>\n

\u0632\u064a\u0646\u0647 \u0623\u0628\u0648 \u0634\u0627\u0645\u064a: \u0627\u0644\u0628\u0627\u062d\u062b \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u060c \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0639\u0645\u0644\u064a \u0645\u0646 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0646\u0638\u0631\u064a\u0629 \u0644\u0644\u0623\u0637\u0631\u0648\u062d\u0629 \u0648\u0627\u0644\u0645\u0642\u0627\u0644\u0629.<\/p>\n

\u0645\u0631\u0648\u0627\u0646 \u0627\u0644\u062d\u0644\u0628\u064a: \u0627\u0644\u0645\u0634\u0631\u0641 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u060c \u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0639\u0644\u0649 \u062c\u0645\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0627\u0644\u0645\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a.<\/p>\n

\u0644\u0645\u0649 \u064a\u0648\u0633\u0641: \u0627\u0644\u0645\u0634\u0631\u0641 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0644\u0644\u0628\u062d\u062b\u060c \u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u062c\u0645\u064a\u0639 \u062a\u0641\u0627\u0635\u064a\u0644 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u062a\u0635\u0645\u064a\u0645 \u062e\u0637\u0629 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u062a\u0648\u062c\u064a\u0647\u0627\u062a \u0641\u064a \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0639\u0645\u0644\u064a \u0648\u062a\u062f\u0642\u064a\u0642 \u0627\u0644\u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0646\u0638\u0631\u064a\u0629.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u062a\u064f\u0639\u064e\u062f\u0651 \u0645\u062a\u0644\u0627\u0632\u0645\u0629\u064f \u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0645\u062a\u0639\u062f\u0651\u062f \u0627\u0644\u0643\u064a\u0633\u0627\u062a (PCOS) Polycystic Ovary Syndrome \u062d\u0627\u0644\u0629\u064b \u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629\u064b \u0634\u0627\u0626\u0639\u0629\u064b \u062a\u0635\u064a\u0628\u064f \u0627\u0644\u0646\u0651\u0633\u0627\u0621 \u0641\u064a \u0633\u0646\u0651 \u0627\u0644\u0625\u0646\u062c\u0627\u0628 \u0628\u0646\u0633\u0628\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646…
\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2102,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2095","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-157","volume-9","year-156"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2095"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2095\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2102"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2095"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2095"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}