{"id":2146,"date":"2026-03-15T14:06:30","date_gmt":"2026-03-15T14:06:30","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2146"},"modified":"2026-03-15T14:06:30","modified_gmt":"2026-03-15T14:06:30","slug":"%d8%aa%d8%ad%d8%b6%d9%8a%d8%b1-%d9%85%d9%8f%d8%a8%d8%b9%d8%ab%d8%b1%d8%a7%d8%aa-%d8%b5%d9%84%d8%a8%d8%a9-%d9%85%d9%86-%d8%a7%d9%84%d8%a3%d8%a8%d9%8a%d9%83%d8%b3%d8%a7%d8%a8%d8%a7%d9%86-%d8%a8%d8%b7","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2146","title":{"rendered":"\u062a\u062d\u0636\u064a\u0631 \u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0635\u0644\u0628\u0629 \u0645\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0635\u0651\u0647\u0631 \u0648\u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c"},"content":{"rendered":"<p><strong>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 <\/strong><strong>Introduction<\/strong><\/p>\n<p>\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0625\u0631\u0642\u0627\u0621 Hemostasis \u0647\u064a \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0637\u0628\u064a\u0639\u064a\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629\u060c \u064a\u0646\u062a\u062c \u0639\u0646\u0647\u0627 \u062a\u0643\u0648\u064a\u0646 \u062e\u062b\u0631\u0629 \u062a\u0645\u0646\u0639 \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0651\u0632\u064a\u0641.<\/p>\n<p>\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u0651\u064a \u0627\u0644\u062e\u0644\u0644 \u0641\u064a \u062a\u0646\u0638\u064a\u0645 \u0639\u0645\u0644\u064a\u0651\u0629 \u0627\u0644\u0625\u0631\u0642\u0627\u0621 \u0625\u0644\u0649 \u062d\u062f\u0648\u062b \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0646\u0632\u0641\u064a\u0629\u060c \u062a\u062a\u0645\u062b\u0651\u0644 \u0641\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0645\u062b\u0644 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u062a\u062e\u062b\u0651\u0631 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629\u060c \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0635\u0641\u064a\u062d\u0627\u062a \u0627\u0644\u062f\u0651\u0645\u0648\u064a\u0629\u060c \u0648\u0645\u0631\u0636 \u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u064f\u062b\u0627\u0631\u064a \u0627\u0644\u0648\u0631\u064a\u062f\u064a [1].<\/p>\n<p>\u064a\u064f\u0639\u062f\u0651 \u0645\u0631\u0636 \u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u064f\u062b\u0627\u0631\u064a \u0627\u0644\u0648\u0631\u064a\u062f\u064a Venus Thrombo Embolism (VTE) \u062b\u0627\u0644\u062b \u0623\u0643\u062b\u0631 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0634\u064a\u0648\u0639\u0627\u064b \u0628\u0639\u062f \u0627\u062d\u062a\u0634\u0627\u0621 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0633\u0651\u0643\u062a\u0629 \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629\u060c \u0625\u0630 \u064a\u0639\u0627\u0646\u064a \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 900.000 \u0641\u0631\u062f \u0645\u0646 \u0627\u0644\u0633\u0651\u0643\u0627\u0646 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u064a\u0631\u0643\u064a\u0629 \u0643\u0644 \u0639\u0627\u0645 \u0645\u0646 \u0645\u0631\u0636 (VTE)\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0644\u0630\u0644\u0643 \u0647\u0646\u0627\u0643 \u062d\u0648\u0627\u0644\u064a 100.000 \u062d\u0627\u0644\u0629 \u0648\u0641\u0627\u0629 \u0633\u0646\u0648\u064a\u0627\u064b \u0628\u064a\u0646 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0644\u0623\u0633\u0628\u0627\u0628 \u062a\u062a\u0639\u0644\u0642 \u0628\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 [2].<\/p>\n<p>\u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 Apixaban \u062f\u0648\u0627\u0621 \u0641\u0639\u0627\u0644 \u0645\u0636\u0627\u062f \u0644\u0644\u062a\u062e\u062b\u0651\u0631 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645\u060c \u064a\u062b\u0628\u0637 \u0628\u0634\u0643\u0644 \u0627\u0646\u062a\u0642\u0627\u0626\u064a \u0648\u0645\u0628\u0627\u0634\u0631 \u0639\u0627\u0645\u0644 \u0627\u0644\u062a\u062e\u062b\u0651\u0631 \u0627\u0644\u0639\u0627\u0634\u0631 Xa\u060c \u0648\u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u0643\u0639\u0644\u0627\u062c \u0648\u0642\u0627\u0626\u064a \u0644\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0645\u0631\u0636 \u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a \u0627\u0644\u0648\u0631\u064a\u062f\u064a (VTE) \u0628\u0639\u062f \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0633\u062a\u0628\u062f\u0627\u0644 \u0645\u0641\u0635\u0644 \u0627\u0644\u0648\u0631\u0643 \u0623\u0648 \u0627\u0644\u0631\u0643\u0628\u0629 Hip or knee replacement surgeries [3].<\/p>\n<p>\u064a\u0645\u062a\u0644\u0643 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0642\u0627\u0628\u0644\u064a\u0629 \u0630\u0648\u0628\u0627\u0646 \u0636\u0639\u064a\u0641\u0629 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u062d\u064a\u062b \u062a\u0628\u0644\u063a 0.028 mg\/mL \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 24 \u00b0\u0645\u060c \u0648\u062a\u0648\u0627\u0641\u0631 \u062d\u064a\u0648\u064a \u0645\u0646\u062e\u0641\u0636 \u0646\u0633\u0628\u064a\u064b\u0627 \u062d\u0648\u0627\u0644\u064a 50% \u0628\u0639\u062f \u0625\u0639\u0637\u0627\u0626\u0647 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0628\u062c\u0631\u0639\u0629 \u0648\u062d\u064a\u062f\u0629 \u062a\u0642\u062f\u0631 \u0628\u0640 10mg\u060c \u062d\u064a\u062b \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u064f\u0639\u0632\u0649 \u0647\u0630\u0627 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0627\u0644\u0645\u0646\u062e\u0641\u0636 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0625\u0644\u0649 \u0639\u062f\u0645 \u0627\u0645\u062a\u0635\u0627\u0635\u0647 \u0628\u0634\u0643\u0644 \u0643\u0627\u0645\u0644 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062a\u0639\u0631\u0651\u0636\u0647 \u0644\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0628\u0627\u0644\u0645\u0631\u0648\u0631 \u0627\u0644\u0643\u0628\u062f\u064a \u0627\u0644\u0623\u0648\u0644 [3].<\/p>\n<p>\u0643\u0645\u0627 \u064a\u0645\u062a\u0644\u0643 \u0648\u0632\u0646 \u062c\u0632\u064a\u0626\u064a \u064a\u0642\u062f\u0651\u0631 \u0628 459.5 g\/mol\u060c \u0648\u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0645\u0633\u062d\u0648\u0642 \u0623\u0628\u064a\u0636 \u0645\u0627\u0626\u0644 \u0644\u0644\u0648\u0646 \u0627\u0644\u0623\u0628\u064a\u0636 \u0627\u0644\u0645\u064f\u0635\u0641\u0631\u060c \u0648\u0644\u0647 \u0646\u0642\u0637\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0645\u062d\u062f\u0651\u062f\u0629 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 326.53 \u00b0C\u060c \u0648\u0645\u064f\u0639\u0627\u0645\u0644 \u062a\u0648\u0632\u0651\u0639 \u064a\u0642\u062f\u0651\u0631 \u0628\u0640 log P=2.71\u060c \u0648\u0644\u0647 \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u0651\u0627\u0644\u064a\u0629: [4]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2147 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/1-1-300x150.png\" alt=\"\" width=\"312\" height=\"156\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/1-1-300x150.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/1-1.png 402w\" sizes=\"auto, (max-width: 312px) 100vw, 312px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(1)<\/strong><strong>: \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u064a\u0631\u062a\u0628\u0637 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a \u0627\u0644\u0641\u0645\u0648\u064a \u0644\u0644\u062f\u0648\u0627\u0621 \u0628\u0645\u064f\u0639\u062f\u0651\u0644 \u0630\u0648\u0628\u0627\u0646\u0647\u060c \u0641\u0639\u0646\u062f \u062a\u062d\u0633\u064a\u0646 \u0645\u064f\u0639\u062f\u0651\u0644 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0642\u062f \u064a\u0624\u062f\u064a 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\u0627\u0644\u062d\u0627\u0645\u0644 \u0627\u0644\u0628\u0644\u0645\u0631\u064a \u0627\u0644\u0645\u062d\u0628 \u0644\u0644\u0645\u0627\u0621\u060c \u0648\u0639\u0646\u062f\u0645\u0627 \u064a\u062a\u0639\u0631\u0636 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 \u0627\u0644\u0635\u0651\u0644\u0628 \u0644\u0644\u0648\u0633\u0637 \u0627\u0644\u0645\u0627\u0626\u064a\u060c \u064a\u0646\u062d\u0644 \u0627\u0644\u062d\u0627\u0645\u0644 \u0648\u064a\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u0648\u0627\u0621\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u0651\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0645\u0633\u0627\u062d\u0629 \u0627\u0644\u0633\u0651\u0637\u062d \u0648\u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0644\u0644\u062f\u0648\u0627\u0621 \u0636\u0639\u064a\u0641 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644 \u0641\u064a \u0627\u0644\u0645\u0627\u0621\u060c \u0648\u0628\u0627\u0644\u062a\u0651\u0627\u0644\u064a \u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u062a\u0651\u0648\u0627\u0641\u0631 \u0627\u0644\u062d\u064a\u0648\u064a [6].<\/p>\n<p>\u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u062a\u0645 \u0639\u0645\u0644\u064a\u0629 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u062f\u0651\u0629 \u0637\u0631\u0627\u0626\u0642 \u0645\u062b\u0644: \u0627\u0644\u0635\u0651\u0647\u0631\u060c \u062a\u0628\u062e\u064a\u0631 \u0627\u0644\u0645\u064f\u0630\u064a\u0628\u060c \u0627\u0644\u0635\u0651\u0647\u0631 \u0648\u062a\u0628\u062e\u064a\u0631 \u0627\u0644\u0645\u064f\u0630\u064a\u0628\u060c \u0627\u0646\u0628\u062b\u0627\u0642 \u0627\u0644\u0645\u0635\u0647\u0648\u0631 \u0627\u0644\u062d\u0627\u0631\u060c \u0627\u0644\u062a\u062c\u0641\u064a\u062f\u060c \u0648\u0627\u0644\u062a\u062c\u0641\u064a\u0641 \u0628\u0627\u0644\u0625\u0631\u0630\u0627\u0630 [7].<\/p>\n<p>\u064a\u062a\u0645 \u062a\u0648\u0635\u064a\u0641 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u0627\u0626\u0642 \u0645\u062a\u0639\u062f\u062f\u0629\u060c \u0645\u062b\u0644: \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0651\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621(FTIR spectroscopy)\u060c \u0627\u0644\u0651\u0630\u064a \u064a\u062a\u062d\u0631\u0649 \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0648\u0627\u0644\u0628\u0644\u0645\u0631\u0627\u062a\u060c \u0648\u0643\u0630\u0644\u0643 \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a (DSC) \u0648\u0627\u0644\u0651\u0630\u064a \u064a\u062a\u062d\u0631\u0649 \u0625\u0646\u062b\u0627\u0644\u0628\u064a \u0627\u0644\u0627\u0646\u0635\u0647\u0627\u0631 \u0648\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u0651\u062d\u0648\u0644 \u0627\u0644\u0632\u062c\u0627\u062c\u064a (Tg)\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u064a\u0629 \u0648\u0639\u062f\u064a\u0645\u0629 \u0627\u0644\u0634\u0651\u0643\u0644\u060c \u0648\u0642\u0627\u0628\u0644\u064a\u0629 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0628\u0644\u0648\u0631\u060c \u0648\u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0628\u064a\u0646 \u062f\u0648\u0627\u0621: \u062f\u0648\u0627\u0621 \u0648\u062f\u0648\u0627\u0621: \u0628\u0644\u0645\u0631.<\/p>\n<p>\u0623\u0645\u0627 \u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0645\u0627\u0633\u062d (SEM) \u064a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u062a\u062d\u062f\u064a\u062f \u0634\u0643\u0644 \u0627\u0644\u0623\u062c\u0632\u0627\u0621 \u0648\u0623\u0628\u0639\u0627\u062f\u0647\u0627\u060c \u0628\u064a\u0646\u0645\u0627 \u0627\u0646\u0639\u0631\u0627\u062c \u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 (X-Ray) \u0641\u064a\u0633\u0627\u0639\u062f \u0641\u064a \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u0637\u0648\u0627\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u064a\u0629 \u0644\u0644\u0645\u0648\u0627\u062f [8].<\/p>\n<p>\u064a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0625\u0644\u0649 \u062a\u062d\u0636\u064a\u0631 \u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0635\u0644\u0628\u0629 \u0645\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0635\u0647\u0631 (Fusion method)\u060c \u062d\u064a\u062b \u064a\u0639\u062a\u0645\u062f \u0645\u0628\u062f\u0624\u0647\u0627 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0639\u0644\u0649 \u062a\u0633\u062e\u064a\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u062d\u0627\u0645\u0644 \u0625\u0644\u0649 \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0623\u0639\u0644\u0649 \u0645\u0646 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u062d\u0627\u0645\u0644 \u0628\u0642\u0644\u064a\u0644 \u0648\u0645\u0646 \u062b\u0645\u0651 \u062a\u0628\u0631\u064a\u062f \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0644\u064a\u062a\u0635\u0644\u0651\u0628 \u0628\u0633\u0631\u0639\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062d\u0645\u0627\u0645 \u062b\u0644\u062c\u064a \u0645\u0639 \u0627\u0644\u062a\u062d\u0631\u064a\u0643\u060c \u0648\u0623\u062e\u064a\u0631\u0627\u064b \u064a\u062a\u0645\u0651 \u0637\u062d\u0646 \u0627\u0644\u0643\u062a\u0644\u0629 \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0648\u0646\u062e\u0644\u0647\u0627 [7].<\/p>\n<p>\u062a\u0645\u0651 \u062a\u062d\u0636\u064a\u0631 \u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0645\u0639 \u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u062a\u0651\u0627\u0644\u064a\u0629: \u0623\u062d\u0627\u062f\u064a \u0634\u0645\u0639\u0627\u062a \u0627\u0644\u063a\u0644\u064a\u0633\u064a\u0631\u0648\u0644 \u0648\u062d\u0645\u0636 \u0627\u0644\u0634\u0651\u0645\u0639\u060c \u0648\u0627\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 188 \u0648407\u060c \u0648\u0645\u0646 \u062b\u0645\u0651 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u064f\u0631\u062a\u0633\u0645\u0627\u062a \u0627\u0644\u0630\u0651\u0648\u0628\u0627\u0646 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629\u060c \u0648\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0648\u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0648\u0625\u062c\u0631\u0627\u0621 \u062a\u0648\u0635\u064a\u0641 \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u062a\u064a (FTIR) \u0648(DSC).<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Materials and Methods<\/strong><\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f <\/strong><strong>Materials<\/strong><strong>: <\/strong><\/p>\n<ul>\n<li>\u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 Apixaban)) \u0645\u0646 (Hubei Derun Kyushu, China)<\/li>\n<li>\u0623\u062d\u0627\u062f\u064a \u0634\u0645\u0639\u0627\u062a \u0627\u0644\u063a\u0644\u064a\u0633\u064a\u0631\u0648\u0644 Glycerol Monostearate [GMS])) \u0645\u0646 (Kevin, India)<\/li>\n<li>\u062d\u0645\u0636 \u0627\u0644\u0634\u0645\u0639 (Stearic Acid [SA]) \u0645\u0646 (Kevin, India)<\/li>\n<li>\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 188 (Poloxamer 188 [PXM188]) \u0645\u0646 (Sigma-Aldrich, Germany)<\/li>\n<li>\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 407 (Poloxamer 407 [PXM407]) \u0645\u0646 (SIGMA life Science, UK)<\/li>\n<\/ul>\n<p><strong>\u0627\u0644\u0623\u062c\u0647\u0632\u0629 <\/strong><strong>Equipment<\/strong><strong>: <\/strong><\/p>\n<p>\u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u0651\u064a\u0641 \u0627\u0644\u0636\u0651\u0648\u0626\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0651\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0629 T80 UV VIS Spectrophotometer, UK\u060c \u0645\u064a\u0632\u0627\u0646 \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u062d\u0633\u0651\u0627\u0633 Sartorius, Germany\u060c \u0645\u064f\u062d\u0631\u0651\u0643 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a BOECO MSH-300\u060c \u062d\u0645\u0651\u0627\u0645 \u0645\u0627\u0626\u064a \u0645\u0639 \u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0635\u0648\u062a\u064a\u0651\u0629 PHYLO Digital Ultrasonic Cleaner with Heating\u060c \u0645\u0642\u064a\u0627\u0633 \u0628\u0627\u0647\u0627\u0621 HANNA instruments pH 211 Microprocessor pH Meter\u00ae, Germany\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0630\u0651\u0648\u0628\u0627\u0646 \u0627\u0644\u0623\u0648\u0644 Pharma Test (Rotating basket) PT-DT7, Germany\u060c \u0627\u0644\u0645\u0627\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0651\u0641\u0627\u0636\u0644\u064a DSC131, SETARAM, France\u060c \u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0623\u0634\u0639\u0651\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u062d\u0648\u064a\u0644 \u0641\u0648\u0631\u064a\u064a\u0647 Shimadzu IR, Germany.<\/p>\n<p><strong>\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Methods<\/strong><strong>: <\/strong><\/p>\n<p><strong>\u0623\u0648\u0651\u0644\u0627\u064b: \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u0627\u062f\u0651\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0641\u0639\u0651\u0627\u0644\u0629 [9]: <\/strong><\/p>\n<p>\u062a\u0645\u0651 \u062a\u062d\u0636\u064a\u0631 \u0633\u0644\u0627\u0633\u0644 \u0639\u064a\u0627\u0631\u064a\u0629 \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0641\u064a \u0648\u0633\u0637 \u064a\u062d\u0648\u064a \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0630\u0648 pH=6.8 \u0645\u0639 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644\u060c \u062d\u064a\u062b \u062a\u0645\u0651 \u0625\u062b\u0628\u0627\u062a \u0627\u0644\u062e\u0637\u064a\u0651\u0629 \u0648\u062a\u062d\u062f\u064a\u062f \u0645\u062c\u0627\u0644\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a (T80 UV VIS Spectrophotometer, UK) \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0623\u0639\u0638\u0645\u064a 278 nm\u060c \u0645\u0642\u0627\u0628\u0644 \u0645\u062d\u0644\u0648\u0644 \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0630\u0648 pH=6.8 \u0645\u0639 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644 \u0643\u0646\u0627\u0635\u0639.<\/p>\n<p><strong>\u062b\u0627\u0646\u064a\u0627\u064b: \u062a\u062d\u0636\u064a\u0631 \u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0635\u0644\u0628\u0629 \u0645\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646:<\/strong><\/p>\n<p>\u062a\u0645\u0651 \u062a\u062d\u0636\u064a\u0631 \u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0635\u0644\u0628\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 GMS \u0644\u0648\u062d\u062f\u0647\u060c \u0648SA \u0644\u0648\u062d\u062f\u0647 \u0641\u064a \u0635\u064a\u063a\u062a\u064a\u0646 \u0645\u062e\u062a\u0644\u0641\u062a\u064a\u0646 \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0646\u0633\u0628 \u0627\u0644\u0648\u0632\u0646\u064a\u0629 (APX: GMS)\u060c (APX:SA)\u060c (1:100) \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a\u060c \u0648\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0635\u0644\u0628\u0629 \u0628\u0645\u0634\u0627\u0631\u0643\u0629 \u0628\u0644\u0645\u0631 \u0627\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 188 \u0645\u0639 \u0627\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 407 \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0646\u0633\u0628 \u0627\u0644\u0648\u0632\u0646\u064a\u0629 (APX: PXM 188: PXM 407) (1:50:50) \u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u0623\u062b\u064a\u0631 \u062a\u063a\u064a\u0651\u0631 \u0627\u0644\u0633\u0651\u0648\u0627\u063a \u0639\u0644\u0649 \u0642\u0627\u0628\u0644\u064a\u0629 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0635\u0651\u0647\u0631.<\/p>\n<p>\u0648\u064f\u0632\u0646\u062a \u0627\u0644\u0643\u0645\u064a\u0627\u062a \u0627\u0644\u0645\u0637\u0644\u0648\u0628\u0629 \u0645\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0648\u0627\u0644\u0633\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629\u060c \u0648\u0648\u064f\u0636\u0639 \u0627\u0644\u062d\u0627\u0645\u0644 \u0641\u064a \u0628\u064a\u0634\u0631 \u0639\u0644\u0649 \u062d\u0645\u0627\u0645 \u0645\u0627\u0626\u064a \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 70\u00b0 \u0645\u0626\u0648\u064a\u0629 \u062d\u062a\u0649 \u062a\u0645\u0627\u0645 \u0627\u0644\u0627\u0646\u0635\u0647\u0627\u0631\u060c \u062b\u0645\u0651 \u0623\u064f\u0636\u064a\u0641 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0625\u0644\u0649 \u0645\u0635\u0647\u0648\u0631 \u0627\u0644\u062d\u0627\u0645\u0644 \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0627\u0645 \u0627\u0644\u0645\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u062a\u062d\u0631\u064a\u0643 \u062d\u062a\u0649 \u062a\u0645\u0627\u0645 \u0627\u0644\u062a\u0651\u062c\u0627\u0646\u0633\u060c \u0648\u0645\u0646 \u062b\u0645\u0651 \u062a\u0645\u0651 \u062a\u0628\u0631\u064a\u062f \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0633\u0651\u0627\u0628\u0642 \u0639\u0644\u0649 \u062d\u0645\u0627\u0645 \u062b\u0644\u062c\u064a \u0645\u0639 \u0627\u0644\u0627\u0633\u062a\u0645\u0631\u0627\u0631 \u0628\u0627\u0644\u062a\u0651\u062d\u0631\u064a\u0643 \u062d\u062a\u0649 \u062a\u0645\u0627\u0645 \u062a\u0635\u0644\u064f\u0651\u0628 \u0627\u0644\u0645\u0632\u064a\u062c\u060c \u0648\u0628\u0639\u062f\u0647\u0627 \u062a\u0645\u0651 \u062d\u0641\u0638 \u0627\u0644\u0645\u0632\u064a\u062c \u0641\u064a \u0627\u0644\u0645\u064f\u062c\u0641\u0641 (Desiccator) \u0645\u062f\u0629 24 \u0633\u0627\u0639\u0629 \u0644\u0644\u062a\u062e\u0644\u0651\u0635 \u0645\u0646 \u0627\u0644\u0631\u0637\u0648\u0628\u0629\u060c \u0648\u0623\u062e\u064a\u0631\u0627\u064b \u0637\u064f\u062d\u0646 \u0627\u0644\u0646\u0627\u062a\u062c \u0641\u064a \u0627\u0644\u0647\u0627\u0648\u0646 \u0648\u062a\u0645\u0651 \u062a\u0645\u0631\u064a\u0631\u0647 \u0639\u0644\u0649 \u0645\u0646\u062e\u0644 \u0628\u0623\u0628\u0639\u0627\u062f 355 \u0645\u0627\u064a\u0643\u0631\u0648\u0645\u062a\u0631\u060c \u0648\u062d\u064f\u0641\u0638 \u0641\u064a \u0627\u0644\u0645\u064f\u062c\u0641\u0651\u0641 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u063a\u0631\u0641\u0629 (25 \u00b0C) \u0644\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0641\u062d\u0648\u0635\u0627\u062a \u0627\u0644\u0645\u0637\u0644\u0648\u0628\u0629. \u064a\u0648\u0636\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (1) \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0631\u0629.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2148 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/2-1-300x83.png\" alt=\"\" width=\"423\" height=\"117\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/2-1-300x83.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/2-1-768x213.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/2-1.png 850w\" sizes=\"auto, (max-width: 423px) 100vw, 423px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u062b\u0627\u0644\u062b\u0627\u064b: \u062d\u0633\u0627\u0628 \u0627\u0644\u0645\u0631\u062f\u0648\u062f <\/strong><strong>Production yield PY<\/strong><strong>% [10]: <\/strong><\/p>\n<p>\u062a\u0645\u0651 \u062d\u0633\u0627\u0628 \u0627\u0644\u0645\u0631\u062f\u0648\u062f \u0644\u0643\u0644 \u0645\u064f\u0628\u0639\u062b\u0631 \u0645\u0646 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0631\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062d\u0633\u0627\u0628 \u0627\u0644\u062f\u0642\u064a\u0642 \u0644\u0644\u0648\u0632\u0646 \u0627\u0644\u0628\u062f\u0626\u064a \u0644\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0648\u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0646\u0647\u0627\u0626\u064a \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0646\u0651\u0627\u062a\u062c\u0629 \u0648\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0645\u0639\u0627\u062f\u0644\u0629:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u0627\u0644\u0645\u0631\u062f\u0648\u062f PY%= (\u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0639\u0645\u0644\u064a \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \/ \u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u0646\u0638\u0631\u064a \u0644\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u062d\u0627\u0645\u0644) \u00d7 100.<\/p>\n<p><strong>\u0631\u0627\u0628\u0639\u0627\u064b: \u062d\u0633\u0627\u0628 \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 <\/strong><strong>Drug content DC<\/strong><strong>% [11]:<\/strong><\/p>\n<p>\u062a\u0645\u0651 \u0648\u0632\u0646 \u0643\u0645\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 \u0627\u0644\u0635\u0651\u0644\u0628 \u062a\u0639\u0627\u062f\u0644 \u0644 (1mg) \u062f\u0648\u0627\u0621 \u0648\u062d\u0644\u0651\u0647\u0627 \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u064f\u0639\u0627\u064a\u0631 \u0633\u0639\u0629 10 \u0645\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0641\u064a \u0627\u0644\u0635\u0651\u064a\u063a S1 \u0648S2\u060c \u0648\u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0630\u0648 pH=6.8 \u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 S3\u060c \u0648\u0628\u0639\u062f\u0647\u0627 \u062a\u0645\u0651 \u0648\u0636\u0639 \u0627\u0644\u0645\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0639\u0644\u0649 \u062d\u0645\u0627\u0645 \u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0645\u062f\u0651\u0629 10 \u062f\u0642\u0627\u0626\u0642 \u062d\u062a\u0651\u0649 \u062a\u0645\u0627\u0645 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u060c \u062b\u0645\u0651 \u0623\u064f\u062e\u0630 1 \u0645\u0644 \u0645\u0646 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0633\u0651\u0627\u0628\u0642 \u0648\u062a\u0645\u0651 \u062a\u0645\u062f\u064a\u062f\u0647 \u0641\u064a \u0628\u0627\u0644\u0648\u0646 \u0645\u064f\u0639\u0627\u064a\u0631 \u0633\u0639\u0629 10 \u0645\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0641\u064a \u0627\u0644\u0635\u0651\u064a\u063a S1 \u0648S2\u060c \u0648\u0627\u0644\u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0641\u064a \u0627\u0644\u0635\u0651\u064a\u063a\u0629 S3 \u062d\u062a\u0651\u0649 \u062e\u0637 \u0627\u0644\u0639\u064a\u0627\u0631\u060c \u0648\u062a\u0645\u0651 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0628\u0639\u062f \u062a\u0631\u0634\u064a\u062d\u0647 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0631\u0634\u062d\u0629 \u0645\u064a\u0643\u0631\u0648\u064a\u0629 (0.45 \u0645\u064a\u0643\u0631\u0648\u0646) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u0651\u064a\u0641 \u0627\u0644\u0636\u0651\u0648\u0626\u064a \u0639\u0646\u062f \u0637\u0648\u0644 \u0645\u0648\u062c\u0629 \u0627\u0645\u062a\u0635\u0627\u0635 \u0623\u0639\u0638\u0645\u064a 278 \u0646\u0627\u0646\u0648\u0645\u062a\u0631 \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0645\u064a\u062b\u0627\u0646\u0648\u0644 \u0643\u0646\u0627\u0635\u0639 \u0641\u064a \u0627\u0644\u0635\u0651\u064a\u063a S1 \u0648S2\u060c \u0648\u0627\u0644\u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0643\u0646\u0627\u0635\u0639 \u0641\u064a \u0627\u0644\u0635\u0651\u064a\u063a\u0629 S3\u060c \u0628\u0639\u062f \u062a\u062d\u0631\u0651\u064a \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062a\u062f\u0627\u062e\u0644 \u0627\u0644\u0633\u0651\u0648\u0627\u063a \u0641\u064a \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0639\u0646\u062f \u0637\u0648\u0644 \u0627\u0644\u0645\u0648\u062c\u0629 \u0627\u0644\u0633\u0627\u0628\u0642. \u0628\u0639\u062f \u0630\u0644\u0643 \u062a\u0645\u0651 \u062d\u0633\u0627\u0628 \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 DC%= (\u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0641\u0639\u0644\u064a \u0644\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0646\u0651\u0627\u062a\u062c\u0629 \/ \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0646\u0651\u0638\u0631\u064a \u0644\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0645\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629) \u00d7 100.<\/p>\n<p><strong>\u062e\u0627\u0645\u0633\u0627\u064b: \u062f\u0631\u0627\u0633\u0629 \u0645\u064f\u0639\u062f\u0651\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c <\/strong><strong>in vitro drug dissolution rate<\/strong><strong>: <\/strong><\/p>\n<p>\u062a\u0645\u0651 \u062f\u0631\u0627\u0633\u0629 \u0645\u064f\u0639\u062f\u0651\u0644\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0645\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0646\u0651\u0627\u062a\u062c\u0629 \u0628\u0648\u0632\u0646 \u0643\u0645\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 \u0627\u0644\u0635\u0651\u0644\u0628 \u062a\u0639\u0627\u062f\u0644 2.5 \u0645\u0644\u063a \u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0641\u064a \u0648\u0633\u0637 \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0630\u0648 pH= 6.8 \u0645\u0639 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644 \u062d\u062c\u0645\u0647 200 \u0645\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0641\u062d\u0635 \u0627\u0644\u0630\u0651\u0648\u0628\u0627\u0646 I (\u0627\u0644\u0633\u0644\u0651\u0629 \u0627\u0644\u062f\u0648\u0627\u0631\u0629)\u060c \u0648\u0628\u0633\u0631\u0639\u0629 \u062f\u0648\u0631\u0627\u0646 50 \u062f\u0648\u0631\u0629 \/ \u0627\u0644\u062f\u0642\u064a\u0642\u0629\u060c \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 32 \u00b1 0.5\u00b0 \u0645\u0626\u0648\u064a\u0629\u060c \u0648\u0633\u064f\u062d\u0628\u062a \u0639\u064a\u0646\u0627\u062a \u0628\u062d\u062c\u0645 5 \u0645\u0644 \u0639\u0646\u062f \u0627\u0644\u0623\u0632\u0645\u0646\u0629 (0.25\u060c 0.33\u060c 0.5\u060c 0.75\u060c 1\u060c 2\u060c 3\u060c 4\u060c 5\u060c 6\u060c 7\u060c 24) \u0633\u0627\u0639\u0629\u060c \u0648\u062a\u0645\u0651 \u062a\u0639\u0648\u064a\u0636 \u0627\u0644\u062d\u062c\u0645 \u0627\u0644\u0645\u0633\u062d\u0648\u0628 \u0628\u0640 5 \u0645\u0644 \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0630\u0648 pH= 6.8 \u0645\u0639 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644\u060c \u062b\u0645\u0651 \u0642\u064a\u0633\u062a \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u0651\u064a\u0641 \u0627\u0644\u0636\u0651\u0648\u0626\u064a \u0639\u0646\u062f 278 \u0646\u0627\u0646\u0648\u0645\u062a\u0631 \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0648\u0642\u0627\u0621 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0645\u0639 10% \u0627\u064a\u062b\u0627\u0646\u0648\u0644 \u0643\u0646\u0627\u0635\u0639.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0633\u0627\u062f\u0633\u0627\u064b: \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0623\u0634\u0639\u0651\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (<\/strong><strong>FTIR<\/strong><strong>): <\/strong><\/p>\n<p>\u062a\u0645\u0651 \u0627\u0644\u0645\u0633\u062d \u0628\u0627\u0644\u0623\u0634\u0639\u0651\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646\u060c GMS\u060c SA\u060c PXM 188\u060c PXM 407\u060c \u0648\u0627\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0645\u0639 \u0643\u0644 \u0633\u0648\u0627\u063a \u0628\u0646\u0633\u0628\u0629 (1:1)\u060c \u0648\u0644\u0644\u0645\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629.<\/p>\n<p><strong>\u0633\u0627\u0628\u0639\u0627\u064b: \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a (<\/strong><strong>DSC<\/strong><strong>): <\/strong><\/p>\n<p>\u0623\u064f\u062c\u0631\u064a \u0641\u062d\u0635 \u0627\u0644 DSC \u0639\u0644\u0649 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0648\u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629\u060c \u062d\u064a\u062b \u062a\u0645\u0651 \u0648\u0636\u0639 \u062d\u0648\u0627\u0644\u064a 5 \u0645\u0644\u063a \u0645\u0646 \u0643\u0644 \u0639\u064a\u0646\u0629 \u0645\u0648\u0632\u0648\u0646\u0629 \u0628\u062f\u0642\u0629 \u0636\u0645\u0646 \u0628\u0648\u062a\u0642\u0629 \u0623\u0644\u0645\u0646\u064a\u0648\u0645 \u0645\u064f\u062d\u0643\u0645\u0629 \u0627\u0644\u0625\u063a\u0644\u0627\u0642\u060c \u0648\u0639\u064f\u0631\u0651\u0650\u0636\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0625\u0644\u0649 \u062f\u0631\u062c\u0627\u062a \u062d\u0631\u0627\u0631\u0629 \u0628\u064a\u0646 25\u00b0-450\u00b0 \u0645\u0626\u0648\u064a\u0629\u060c \u0628\u0645\u0639\u062f\u0651\u0644 10 \u062f\u0631\u062c\u0629 \/ \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0641\u064a \u062c\u0648 \u063a\u0627\u0632 \u0645\u0646 \u0627\u0644\u0622\u0632\u0648\u062a \u0628\u0645\u0639\u062f\u0651\u0644 100 \u0645\u0644\/\u062f\u0642\u064a\u0642\u0629.<\/p>\n<p><strong>\u062b\u0627\u0645\u0646\u0627\u064b: \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629:<\/strong><\/p>\n<p>\u062a\u0645\u0651 \u0627\u0639\u062a\u0645\u0627\u062f \u0627\u062e\u062a\u0628\u0627\u0631 (One-way Anova) \u0644\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0645\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 Microsoft Excel 2016\u060c \u0648\u0627\u0639\u062a\u064f\u0628\u0631\u062a \u0627\u0644\u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062f\u0644\u0627\u0644\u0629 (P&lt;0.05).<\/p>\n<p><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Results and Discussion<\/strong><\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0645\u064f\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0645\u0627\u062f\u0651\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629: <\/strong><\/p>\n<p>\u062a\u0645\u0651 \u062f\u0631\u0627\u0633\u0629 \u062e\u0637\u0651\u064a\u0629 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u062a\u0651\u0628\u0639\u0629 \u0643\u0645\u0627 \u0641\u064a \u0627\u0644\u0634\u0651\u0643\u0644 (2) \u0627\u0644\u0651\u0630\u064a \u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0645\u062a\u0648\u0633\u0651\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u0644\u062b\u0644\u0627\u062b \u0645\u0643\u0631\u0631\u0627\u062a \u0644\u0643\u0644 \u0642\u064a\u0627\u0633\u060c \u062d\u064a\u062b \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0645\u0627\u062f\u0651\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u062e\u0637\u0651\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 (5-25 \u00b5g\/mL) \u0648\u0645\u0639\u0627\u062f\u0644\u0629 \u0627\u0644\u062e\u0637 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 y=0.0319x-0.0144 \u0645\u0639 \u0642\u064a\u0645\u0629 \u0645\u064f\u0639\u0627\u0645\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 R<sup>2<\/sup>=0.9991.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2149 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/3-1-300x150.png\" alt=\"\" width=\"350\" height=\"175\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/3-1-300x150.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/3-1.png 405w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(2)<\/strong><strong>: \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0639\u064a\u0627\u0631\u064a\u0629 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0641\u064a \u0648\u0633\u0637 \u064a\u062d\u0648\u064a \u0648\u0642\u0627\u0621 \u0641\u0648\u0633\u0641\u0627\u062a\u064a \u0630\u0648 <\/strong><strong>pH=6.8<\/strong><strong> \u0645\u0639 <\/strong><strong>10%<\/strong><strong> \u0627\u064a\u062b\u0627\u0646\u0648\u0644<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0631\u062f\u0648\u062f <\/strong><strong>Production yield PY<\/strong><strong>% \u0648\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 <\/strong><strong>Drug content DC<\/strong><strong>%:<\/strong><\/p>\n<p>\u0628\u0644\u063a \u0627\u0644\u0645\u0631\u062f\u0648\u062f \u0623\u0639\u0644\u0649 \u0642\u064a\u0645\u0629 \u0644\u0647 \u0641\u064a \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S1 \u0648\u0643\u0627\u0646 99.1%\u060c \u0648\u0623\u0642\u0644 \u0642\u064a\u0645\u0629 \u0643\u0627\u0646\u062a \u0639\u0627\u0626\u062f\u0629 \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S3 \u062d\u064a\u062b \u0628\u0644\u063a\u062a 89.2%.<\/p>\n<p>\u0623\u0645\u0627 \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0643\u0627\u0646 \u0623\u0639\u0644\u0649 \u0642\u064a\u0645\u0629 \u0644\u0647 \u0623\u064a\u0636\u0627\u064b \u0641\u064a \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S1 \u062d\u064a\u062b \u0628\u0644\u063a 99.5%\u060c \u0648\u0623\u0642\u0644 \u0642\u064a\u0645\u0629 \u0644\u0647 \u0641\u064a \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S3 \u0625\u0630 \u0628\u0644\u063a\u062a 91.6%.<\/p>\n<p>\u0648\u064a\u0648\u0636\u0651\u062d \u0627\u0644\u062c\u062f\u0648\u0644 (2) \u0642\u064a\u0645 \u0627\u0644\u0645\u0631\u062f\u0648\u062f \u0648\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2150 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/4-1-300x162.png\" alt=\"\" width=\"337\" height=\"182\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/4-1-300x162.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/4-1.png 442w\" sizes=\"auto, (max-width: 337px) 100vw, 337px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 \u0645\u064f\u0639\u062f\u0651\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0632\u062c\u0627\u062c:<\/strong><\/p>\n<p>\u064a\u064f\u0628\u064a\u0651\u0646 \u0627\u0644\u0634\u0651\u0643\u0644 (3) \u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u062a\u062d\u0631\u0651\u0631\u0629 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0645\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0635\u0651\u0647\u0631 \u0648\u0647\u064a: S1 (APX: GMS)\u060c S2 (APX:SA) \u0648S3 (APX: PXM188:PXM407)\u060c \u062d\u064a\u062b \u0623\u0638\u0647\u0631\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u0635\u0651\u064a\u063a \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629 \u0645\u0639\u062f\u0651\u0644\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0623\u0633\u0631\u0639 \u0645\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0627\u0644\u0646\u0642\u064a.<\/p>\n<p>\u0641\u064a \u0627\u0644\u0635\u064a\u063a\u0629 S1 \u0642\u062f \u0623\u062f\u0651\u0649 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u062a\u0651\u062d\u0631\u0631 \u0639\u0646\u062f \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 (0.25, 0.33, 0.5, 0.75, 1, 2) h \u0648\u0628\u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P&lt;0.05)\u060c \u0648\u0628\u0639\u062f \u0630\u0644\u0643 \u0644\u0645 \u064a\u064f\u0644\u0627\u062d\u0638 \u0641\u0627\u0631\u0642 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0646\u0642\u064a\u060c \u0625\u0630 \u0623\u0646\u0651 \u0648\u062c\u0648\u062f GMS \u0648\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u062d\u0636\u064a\u0631 \u062a\u0624\u062f\u0651\u064a\u0627\u0646 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u062a\u0628\u0644\u0651\u064f\u0644 \u0648\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0639\u0646\u062f \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 [12].<\/p>\n<p>\u0623\u0645\u0651\u0627 \u0641\u064a \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S2 \u0625\u0646\u0651 \u0648\u062c\u0648\u062f \u0627\u0644 SA \u0642\u062f \u0623\u062f\u0651\u0649 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0645\u0639\u062f\u0651\u0644\u0627\u062a \u0627\u0644\u062a\u0651\u062d\u0631\u0631 \u0639\u0646\u062f \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 (0.25, 0.33, 3, 4, 5) h\u060c \u0648\u0628\u0641\u0648\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P&lt;0.05)\u060c \u0648\u0643\u0627\u0646\u062a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u0631 \u0628\u0639\u062f 5 \u0633\u0627\u0639\u0627\u062a\u060c \u0625\u0630 \u0623\u0646\u0651 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062b\u0644 \u0647\u0630\u0647 \u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0644\u0625\u0646\u0634\u0627\u0621 \u0645\u0637\u0631\u0633 \u064a\u062d\u0648\u064a \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u062d\u0628\u0651\u0629 \u0644\u0644\u0645\u0627\u0621 \u0648\u0623\u062e\u0631\u0649 \u0643\u0627\u0631\u0647\u0629 \u0644\u0644\u0645\u0627\u0621 \u064a\u0624\u062f\u0651\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0651\u0648\u0627\u0621\u060c \u062d\u064a\u062b \u062a\u0645\u0651 \u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0645\u0635\u0647\u0648\u0631 \u062d\u0645\u0636 \u0627\u0644\u0634\u0645\u0639 \u0648\u0639\u062f\u0651\u0644 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0628\u0644\u0651\u0648\u0631\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u0625\u0644\u0649 \u0639\u062f\u064a\u0645 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0628\u0644\u0651\u0648\u0631\u064a [13].<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2151 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/5-1-300x204.png\" alt=\"\" width=\"329\" height=\"224\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/5-1-300x204.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/5-1.png 412w\" sizes=\"auto, (max-width: 329px) 100vw, 329px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 (<\/strong><strong>3<\/strong><strong>): \u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u062d\u0631\u0651\u0631\u0629 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0645\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 <\/strong><strong>S1<\/strong><strong> \u0648<\/strong><strong>S2<\/strong><strong> \u0648<\/strong><strong>S3<\/strong><strong>.<\/strong><\/p>\n<p>\u0623\u0645\u0651\u0627 \u0627\u0644\u0635\u0651\u064a\u063a\u0629 S3 \u0641\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0623\u0633\u0631\u0639 \u0645\u064f\u0639\u062f\u0651\u0644\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0648\u0628\u0641\u0627\u0631\u0642 \u064a\u064f\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P&lt;0.05) \u0639\u0646\u062f \u0627\u0644\u0623\u0632\u0645\u0646\u0629 \u0627\u0644\u062b\u0651\u0644\u0627\u062b \u0627\u0644\u0623\u0648\u0644\u0649 (0.25, 0.33, 0.5) h\u060c \u062d\u064a\u062b \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u062a\u062d\u0631\u0651\u0631\u0629 \u0628\u0639\u062f \u0645\u0631\u0648\u0631 30 \u062f\u0642\u064a\u0642\u0629 (95.6%)\u00b10.54\u060c \u0642\u062f \u064a\u0643\u0648\u0646 \u0630\u0644\u0643 \u0639\u0627\u0626\u062f \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0632\u064a\u062c \u0645\u0646 PXM188 \u0648PXM407 \u0627\u0644\u0623\u0643\u062b\u0631 \u062d\u0628\u0651\u0627\u064b \u0644\u0644\u0645\u0627\u0621 \u0641\u0623\u062f\u0649 \u0630\u0644\u0643 \u0644\u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u062e\u0644\u0627\u0644 \u0623\u0642\u0644 \u0645\u0646 \u0646\u0635\u0641 \u0633\u0627\u0639\u0629 [14].<\/p>\n<p><strong>\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0637\u064a\u0627\u0641 \u0627\u0644\u0623\u0634\u0639\u0651\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 (<\/strong><strong>FTIR<\/strong><strong>):<\/strong><\/p>\n<p>\u064a\u064f\u0628\u062f\u064a \u0627\u0644\u0634\u0651\u0643\u0644 (4) \u0645\u062e\u0637\u0637 (FTIR) \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646\u060c \u062d\u064a\u062b \u064a\u064f\u0638\u0647\u0631 \u0642\u0645\u0645 \u0639\u0646\u062f: 3483 cm-1 \u062a\u0645\u062b\u0651\u0644 \u0627\u0647\u062a\u0632\u0627\u0632 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0627\u0644\u0645\u062a\u0646\u0627\u0638\u0631\u0629 \u0648\u0627\u0644\u063a\u064a\u0631 \u0645\u062a\u0646\u0627\u0638\u0631\u0629\u060c 2974 cm-1\u00a0 \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 C-H \u0644 CH3\u060c 2909 cm-1 \u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 C-H\u060c 1679 cm-1 \u062a\u0645\u062b\u0651\u0644 \u0627\u0647\u062a\u0632\u0627\u0632 \u0645\u062c\u0645\u0648\u0639\u0629 \u0643\u0631\u0628\u0648\u0646\u064a\u0644 \u0623\u0645\u064a\u062f\u00a0\u00a0\u00a0\u00a0 N-C=O\u060c 1594 cm-1 \u062a\u0645\u062b\u0651\u0644 \u0627\u0646\u062d\u0646\u0627\u0621 C-H\u060c 1504 cm-1 \u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 C=C \u0641\u064a \u062d\u0644\u0642\u0629 \u0627\u0644\u0628\u0646\u0632\u064a\u0646\u060c 1294 cm-1 \u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0625\u064a\u062b\u0631 C-O\u060c 1144 cm-1 \u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 C-O\/C-N [15,16].<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2152 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/6-1-300x110.png\" alt=\"\" width=\"398\" height=\"146\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/6-1-300x110.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/6-1.png 718w\" sizes=\"auto, (max-width: 398px) 100vw, 398px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 (<\/strong><strong>4<\/strong><strong>)<\/strong><strong>:<\/strong><strong> \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0646\u0651\u0642\u064a<\/strong><\/p>\n<p>\u064a\u064f\u0628\u062f\u064a \u0627\u0644\u0634\u0651\u0643\u0644 (5) \u0645\u062e\u0637\u0637 (FTIR) \u0644\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 188\u060c \u0625\u0630 \u064a\u064f\u0638\u0647\u0631 \u0642\u0645\u0645 \u0639\u0646\u062f: 2882 cm<sup>-1<\/sup> \u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 C-H \u0627\u0644\u0623\u0644\u064a\u0641\u0627\u062a\u064a\u0629\u060c 1341 cm<sup>-1<\/sup> \u062a\u0645\u062b\u0651\u0644 \u0627\u0646\u062d\u0646\u0627\u0621 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 O-H\u060c 1098 cm<sup>-1<\/sup>\u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 C-O [16].<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2153 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/7-1-300x111.png\" alt=\"\" width=\"430\" height=\"159\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/7-1-300x111.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/7-1.png 711w\" sizes=\"auto, (max-width: 430px) 100vw, 430px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(5)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0628\u0644\u0645\u0631 <\/strong><strong>Poloxamer 188<\/strong><\/p>\n<p>\u064a\u064f\u0628\u062f\u064a \u0627\u0644\u0634\u0651\u0643\u0644 (6) \u0645\u062e\u0637\u0637 (FTIR) \u0644\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 407\u060c \u062d\u064a\u062b \u064a\u064f\u0628\u062f\u064a \u0642\u0645\u0645 \u0639\u0646\u062f: 2880 cm<sup>-1<\/sup> \u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 C-H \u0627\u0644\u0623\u0644\u064a\u0641\u0627\u062a\u064a\u0629\u060c 1341 cm<sup>-1<\/sup> \u062a\u0645\u062b\u0651\u0644 \u0627\u0646\u062d\u0646\u0627\u0621 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 O-H\u060c 1100 cm<sup>-1<\/sup>\u062a\u0645\u062b\u0651\u0644 \u0627\u0645\u062a\u0637\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 C-O [16].<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2154 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/8-1-300x107.png\" alt=\"\" width=\"404\" height=\"144\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/8-1-300x107.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/8-1.png 717w\" sizes=\"auto, (max-width: 404px) 100vw, 404px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(6)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0628\u0644\u0645\u0631 <\/strong><strong>Poloxamer 407<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u064a\u064f\u0648\u0636\u0651\u062d \u0627\u0644\u0634\u0651\u0643\u0644 (7) \u0648\u0627\u0644\u0634\u0651\u0643\u0644 (8) \u0648\u0627\u0644\u0634\u064f\u0643\u0644 (9) \u0645\u062e\u0637\u0637\u0627\u062a (FTIR) \u0644\u0644\u0645\u0632\u0627\u0626\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0643\u0644 \u0645\u0646 APX: GMS \u0648APX: SA \u0648APX: PXM407 \u0628\u0646\u0633\u0628\u0629 1:1 \u0639\u0644\u0649 \u0627\u0644\u062a\u0651\u0631\u062a\u064a\u0628\u060c \u0625\u0630 \u064a\u064f\u0644\u0627\u062d\u0638 \u0627\u0646\u0632\u064a\u0627\u062d \u0637\u0641\u064a\u0641 \u0641\u064a \u0642\u0645\u0645 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 N-H\u060c \u0648\u064a\u064f\u0644\u0627\u062d\u0638 \u0627\u0646\u0632\u064a\u0627\u062d \u0637\u0641\u064a\u0641 \u0641\u064a \u0642\u0645\u0645 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064a\u0644\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631 \u0637\u0641\u064a\u0641\u060c \u0642\u062f \u064a\u0643\u0648\u0646 \u0646\u0627\u062a\u062c\u0627\u064b \u0639\u0646 \u062a\u0634\u0643\u064a\u0644 \u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u064a\u0646.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2155 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/9-1-300x120.png\" alt=\"\" width=\"400\" height=\"160\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/9-1-300x120.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/9-1.png 705w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(7)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a <\/strong><strong>(APX: GMS)<\/strong><strong> \u0628\u0646\u0633\u0628\u0629 <\/strong><strong>1:1<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2156 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/10-300x117.png\" alt=\"\" width=\"392\" height=\"153\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/10-300x117.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/10.png 710w\" sizes=\"auto, (max-width: 392px) 100vw, 392px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(8)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a <\/strong><strong>(APX: SA)<\/strong><strong> \u0628\u0646\u0633\u0628\u0629 <\/strong><strong>1:1<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2157 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/11-300x122.png\" alt=\"\" width=\"389\" height=\"158\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/11-300x122.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/11.png 708w\" sizes=\"auto, (max-width: 389px) 100vw, 389px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(9)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a <\/strong><strong>(APX: PXM407)<\/strong><strong> \u0628\u0646\u0633\u0628\u0629 <\/strong><strong>1:1<\/strong><\/p>\n<p>\u064a\u064f\u0648\u0636\u0651\u062d \u0627\u0644\u0634\u0643\u0644 (10) \u0645\u062e\u0637\u0637 (FTIR) \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a APX + PXM 188 \u0628\u0646\u0633\u0628\u0629 (1:1)\u060c \u0625\u0630 \u0644\u0645 \u064a\u064f\u0644\u0627\u062d\u0638 \u0627\u0646\u0632\u064a\u0627\u062d \u0641\u064a \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0644\u0645\u0631\u0643\u0628\u064a\u0646\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u064a\u0646.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2158 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/12-300x125.png\" alt=\"\" width=\"403\" height=\"168\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/12-300x125.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/12.png 712w\" sizes=\"auto, (max-width: 403px) 100vw, 403px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(10)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a <\/strong><strong>(APX: PXM188)<\/strong><strong> \u0628\u0646\u0633\u0628\u0629 <\/strong><strong>1:1<\/strong><\/p>\n<p>\u064a\u064f\u0648\u0636\u0651\u062d \u0627\u0644\u0634\u0643\u0644 (11) \u0645\u062e\u0637\u0637 (FTIR) \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u064e\u0631 S3 (APX: PXM 188: PXM 407) (1:50:50)\u060c \u062d\u064a\u062b \u064a\u064f\u0644\u0627\u062d\u064e\u0638 \u0623\u0646\u0651 \u0637\u064a\u0641 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S3 \u0645\u0634\u0627\u0628\u0647 \u0644\u0637\u064a\u0641 \u0627\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 (188,407)\u060c \u0645\u0639 \u0627\u062e\u062a\u0641\u0627\u0621 \u0641\u064a \u0623\u063a\u0644\u0628 \u0627\u0644\u0642\u0645\u0645 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646\u060c \u0648\u0647\u0630\u0627 \u0642\u062f \u064a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0646\u062f\u0645\u0627\u062c \u0627\u0644\u0645\u0627\u062f\u0651\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0641\u0639\u0651\u0627\u0644\u0629 \u0636\u0645\u0646 \u0645\u0637\u0631\u0633 \u0627\u0644\u0628\u0644\u0645\u0631\u060c \u0643\u0630\u0644\u0643 \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u0627\u0646\u0632\u064a\u0627\u062d\u0627\u062a \u0637\u0641\u064a\u0641\u0629 \u0641\u064a \u0642\u0645\u0645 \u0627\u0644\u0651\u0633\u0648\u0627\u063a \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0642\u0644\u0651\u0629 \u0627\u0644\u062a\u0622\u062b\u0631\u0627\u062a \u0628\u064a\u0646\u0647\u0645\u0627 \u0648\u0628\u064a\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2159 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/13-300x117.png\" alt=\"\" width=\"413\" height=\"161\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/13-300x117.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/13.png 721w\" sizes=\"auto, (max-width: 413px) 100vw, 413px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(11)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 <\/strong><strong>FTIR<\/strong><strong> \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u0631 <\/strong><strong>S3<\/strong><\/p>\n<p><strong>\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0651\u0641\u0627\u0636\u0644\u064a <\/strong><strong>(DSC)<\/strong><strong>: <\/strong><\/p>\n<p>\u064a\u064f\u0628\u064a\u0651\u0646 \u0627\u0644\u0634\u0651\u0643\u0644 (12) \u0645\u0646\u062d\u0646\u064a \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0651\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0646\u0642\u064a\u060c \u062d\u064a\u062b \u064a\u064f\u0644\u0627\u062d\u0638 \u0648\u062c\u0648\u062f \u0642\u0645\u0651\u0629 \u0645\u0627\u0635\u0651\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 240\u00b0C \u062a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646\u060c \u0648\u0647\u064a \u0642\u0645\u0651\u0629 \u062d\u0627\u062f\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0628\u0644\u0648\u0631\u064a\u0629 \u0648\u0646\u0642\u0627\u0648\u062a\u0647\u060c \u0648\u0647\u0646\u0627\u0643 \u0642\u0645\u0651\u0629 \u0639\u0631\u064a\u0636\u0629 \u0645\u0627\u0635\u0651\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 401\u00b0C\u060c \u0642\u062f \u062a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u0641\u0643\u0643 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0648\u062a\u062e\u0631\u0651\u0628 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 [16].<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2160 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/14-300x126.png\" alt=\"\" width=\"352\" height=\"148\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/14-300x126.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/14.png 698w\" sizes=\"auto, (max-width: 352px) 100vw, 352px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(12)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0651\u0641\u0627\u0636\u0644\u064a <\/strong><strong>DSC<\/strong><strong> \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0646\u0651\u0642\u064a<\/strong><\/p>\n<p>\u064a\u064f\u0628\u064a\u0651\u0646 \u0627\u0644\u0634\u0651\u0643\u0644 (13) \u0645\u0646\u062d\u0646\u064a \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0651\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646\u060c \u0648\u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S3\u060c \u062d\u064a\u062b \u0623\u0646\u064e \u0627\u0644\u0642\u0645\u0651\u0629 \u0627\u0644\u062d\u0627\u062f\u0651\u0629 \u0627\u0644\u0645\u0627\u0635\u0651\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 Endothermic \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 240\u00b0C \u0641\u064a \u0645\u0646\u062d\u0646\u064a \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0646\u0642\u064a \u0642\u062f \u0627\u062e\u062a\u0641\u062a \u0641\u064a \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 S3\u060c \u0648\u0638\u0647\u0631\u062a \u0642\u0645\u0651\u0629 \u062d\u0627\u062f\u0651\u0629 \u0645\u0627\u0635\u0651\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 56\u00b0C \u062a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 188 \u0648\u0627\u0644\u0628\u0648\u0644\u0648\u0643\u0633\u0627\u0645\u064a\u0631 407\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u062d\u0648\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0625\u0644\u0649 \u0627\u0644\u062d\u0627\u0644\u0629 \u0639\u062f\u064a\u0645\u0629 \u0627\u0644\u0634\u0651\u0643\u0644 \u0627\u0644\u0628\u0644\u0651\u0648\u0631\u064a\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0646\u062f\u0645\u0627\u062c \u0627\u0644\u0645\u0627\u062f\u0651\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0641\u0639\u0651\u0627\u0644\u0629 \u0636\u0645\u0646 \u0645\u0637\u0631\u0633 \u0627\u0644\u0628\u0644\u0645\u0631\u060c \u0643\u0630\u0644\u0643 \u064a\u064f\u0644\u0627\u062d\u0638 \u0639\u062f\u0645 \u0638\u0647\u0648\u0631 \u0642\u0645\u0645 \u062c\u062f\u064a\u062f\u0629.<\/p>\n<p>\u0648\u0628\u0630\u0644\u0643 \u064a\u064f\u0644\u0627\u062d\u0638 \u0623\u0646\u0651 \u0647\u0646\u0627\u0643 \u062a\u0622\u062b\u0631\u0627\u062a \u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0644\u0643\u0646\u0651\u0647\u0627 \u0645\u062d\u062f\u0648\u062f\u0629 \u0643\u0648\u0646\u0647\u0627 \u0630\u0627\u062a \u0637\u0628\u064a\u0639\u0629 \u0643\u0627\u0631\u0647\u0629 \u0644\u0644\u0645\u0627\u0621\u060c \u0623\u0648 \u0645\u0646 \u0642\u0648\u0649 \u0641\u0627\u0646\u062f\u0631\u0641\u0627\u0644\u0633\u060c \u0623\u0648 \u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u062a\u0634\u0643\u0651\u0644 \u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2161 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/15-300x123.png\" alt=\"\" width=\"463\" height=\"190\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/15-300x123.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/15.png 736w\" sizes=\"auto, (max-width: 463px) 100vw, 463px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0651\u0643\u0644 <\/strong><strong>(13)<\/strong><strong>: \u0645\u062e\u0637\u0651\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0651\u0641\u0627\u0636\u0644\u064a <\/strong><strong>DSC<\/strong><strong> \u0644\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0648\u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 \u0627\u0644\u0635\u0651\u0644\u0628 <\/strong><strong>S3<\/strong><\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/p>\n<p>\u0627\u0647\u062a\u0645\u0651 \u0627\u0644\u0628\u062d\u062b \u0628\u062a\u0639\u062f\u064a\u0644 \u0645\u0639\u062f\u0651\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0627\u0644\u0636\u0651\u0639\u064a\u0641 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644 \u0641\u064a \u0627\u0644\u0645\u0627\u0621\u060c \u0648\u0630\u0644\u0643 \u0628\u062a\u062d\u0636\u064a\u0631\u0647 \u0639\u0644\u0649 \u0634\u0643\u0644 \u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0635\u0644\u0628\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0635\u0651\u0647\u0631 (Fusion Method)\u060c \u0628\u0647\u062f\u0641 \u062a\u062d\u0633\u064a\u0646 \u062a\u0648\u0627\u0641\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a\u060c \u0648\u064a\u0645\u0643\u0646 \u062a\u0644\u062e\u064a\u0635 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0628\u062d\u062b \u0643\u0645\u0627 \u064a\u0644\u064a:<\/p>\n<ol>\n<li>\u062a\u062d\u0633\u064f\u0651\u0646 \u0645\u0639\u062f\u0651\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0635\u0651\u0647\u0631 \u0645\u064f\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0646\u0642\u064a.<\/li>\n<li>\u0623\u0628\u062f\u0649 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631 \u0627\u0644\u0635\u0651\u0644\u0628 S3 (APX: PXM188: PXM407) (1:50:50) \u0623\u0639\u0644\u0649 \u0645\u064f\u0639\u062f\u0651\u0644\u0627\u062a \u062a\u062d\u0631\u0651\u0631 \u0645\u064f\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u064f\u0628\u0639\u062b\u0631\u0627\u062a \u0627\u0644\u0635\u0651\u0644\u0628\u0629 \u0627\u0644\u0645\u064f\u062d\u0636\u0651\u0631\u0629\u060c \u0648\u0628\u0644\u063a\u062a \u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u062a\u062d\u0631\u0651\u0631\u0629 \u0645\u0646 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646 \u0628\u0639\u062f \u0645\u0631\u0648\u0631 \u0646\u0635\u0641 \u0633\u0627\u0639\u0629 (95.5%).<\/li>\n<li>\u0644\u0645 \u062a\u064f\u0628\u062f\u0650 \u0646\u062a\u0627\u0626\u062c \u0627\u0644 FTIR \u0648\u062c\u0648\u062f \u062a\u0622\u062b\u0631\u0627\u062a \u0645\u0644\u062d\u0648\u0638\u0629 \u0628\u064a\u0646 \u0627\u0644\u062f\u0651\u0648\u0627\u0621 \u0648\u0627\u0644\u0633\u0651\u0648\u0627\u063a\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629.<\/li>\n<li>\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644 DSC \u0644\u0644\u0645\u064f\u0628\u0639\u062b\u0631 \u0627\u0644\u0635\u0651\u0644\u0628 S3\u060c \u0627\u0644\u0651\u0630\u064a \u0623\u0639\u0637\u0649 \u0623\u0639\u0644\u0649 \u0645\u0639\u062f\u0651\u0644 \u0630\u0648\u0628\u0627\u0646\u060c \u0627\u062e\u062a\u0641\u0627\u0621 \u0641\u064a \u0642\u0645\u0651\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0623\u0628\u064a\u0643\u0633\u0627\u0628\u0627\u0646\u060c \u0645\u0645\u0651\u0627 \u0642\u062f \u064a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u062d\u0648\u0651\u0644\u0647 \u0645\u0646 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0628\u0644\u0651\u0648\u0631\u064a\u0629 \u0625\u0644\u0649 \u0639\u062f\u064a\u0645\u0629 \u0627\u0644\u0634\u0651\u0643\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u064a.<\/li>\n<\/ol>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 <\/strong><strong>Ethics approval and consent to participate<\/strong><\/p>\n<p>\u063a\u064a\u0631 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong><strong>Conflict of interests<\/strong><\/p>\n<p>\u064a\u064f\u0642\u0631\u0651 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u064f\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong><strong>Funding<\/strong><\/p>\n<p>\u0645\u064f\u0648\u0651\u0650\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u0642\u0628\u0644 \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong><strong>Author\u2019s contributions<\/strong><\/p>\n<p>\u062a\u0648\u0644\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u0629 (\u0645\u0627\u0631\u064a \u062c\u0631\u064a\u0633 \u0627\u0644\u0635\u0639\u0648\u0628) \u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0646\u0634\u0637\u0629 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u062c\u0645\u0639 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a\u060c \u0627\u0644\u062a\u0651\u062d\u0644\u064a\u0644\u060c \u0643\u062a\u0627\u0628\u0629 \u0627\u0644\u0645\u0642\u0627\u0644.<\/p>\n<p>\u0643\u0627\u0646 \u0627\u0644\u0645\u0634\u0631\u0641 (\u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0645\u062d\u0645\u0651\u062f \u0639\u0628\u062f \u0627\u0644\u0631\u0624\u0648\u0641 \u0639\u062b\u0645\u0627\u0646) \u0645\u0633\u0624\u0648\u0644\u0627\u064b \u0639\u0646 \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0625\u0631\u0634\u0627\u062f\u0627\u062a \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629\u060c \u0648\u0636\u0645\u0627\u0646 \u062c\u0648\u062f\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0633\u0648\u062f\u0629 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0634\u0643\u0631 \u0648\u0627\u0644\u062a\u0642\u062f\u064a\u0631 <\/strong><strong>Acknowledgements<\/strong><\/p>\n<p>\u064a\u062a\u0648\u062c\u0651\u0647 \u0627\u0644\u0645\u0624\u0644\u0651\u0641\u0648\u0646 \u0628\u0641\u0627\u0626\u0642 \u0627\u0644\u0634\u0651\u0643\u0631 \u0644\u0643\u0644 \u0645\u0646: \u0645\u062e\u0627\u0628\u0631 \u0643\u0644\u0651\u064a\u0651\u0629 \u0627\u0644\u0635\u0651\u064a\u062f\u0644\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642\u060c \u0647\u064a\u0626\u0629 \u0627\u0644\u0637\u0651\u0627\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0651\u0629 (\u062f\u0645\u0634\u0642)\u060c \u0645\u062f\u064a\u0631\u064a\u0629 \u0645\u062e\u0627\u0628\u0631 \u0627\u0644\u0631\u0651\u0642\u0627\u0628\u0629 \u0648\u0627\u0644\u0628\u062d\u0648\u062b \u0627\u0644\u062f\u0651\u0648\u0627\u0626\u064a\u0629 (\u062f\u0645\u0634\u0642)\u060c \u0648\u0630\u0644\u0643 \u0644\u0645\u0633\u0627\u0639\u062f\u062a\u0647\u0645 \u0641\u064a \u0625\u0646\u062c\u0627\u0632 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u064f\u062a\u0639\u0644\u0651\u0642\u0629 \u0628\u0627\u0644\u0628\u062d\u062b.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0625\u0631\u0642\u0627\u0621 Hemostasis \u0647\u064a \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0637\u0628\u064a\u0639\u064a\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629\u060c \u064a\u0646\u062a\u062c \u0639\u0646\u0647\u0627 \u062a\u0643\u0648\u064a\u0646 \u062e\u062b\u0631\u0629 \u062a\u0645\u0646\u0639 \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0651\u0632\u064a\u0641. \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u0651\u064a \u0627\u0644\u062e\u0644\u0644&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=2146\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2151,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2146","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-158","volume-9","year-159"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2146"}],"version-history":[{"count":6,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2146\/revisions"}],"predecessor-version":[{"id":2223,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2146\/revisions\/2223"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2151"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}