{"id":2175,"date":"2026-03-15T13:46:33","date_gmt":"2026-03-15T13:46:33","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=2175"},"modified":"2026-03-15T14:02:40","modified_gmt":"2026-03-15T14:02:40","slug":"%d8%aa%d8%a3%d8%ab%d9%8a%d8%b1-%d8%a7%d9%84%d8%aa%d9%91%d8%b9%d8%af%d8%af-%d8%a7%d9%84%d8%b4%d9%91%d9%83%d9%84%d9%8a-%d9%85%d9%81%d8%b1%d8%af-%d8%a7%d9%84%d9%86%d9%83%d9%84%d9%8a%d9%88%d8%aa%d9%8a","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=2175","title":{"rendered":"\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062a\u0651\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f Taq-I (rs731236)  \u0641\u064a \u062c\u064a\u0646 \u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0641\u064a \u0627\u062e\u062a\u0637\u0627\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a \u0648\u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0633\u0648\u0631\u064a\u064a\u0646"},"content":{"rendered":"<p><strong>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 <\/strong><strong>Introduction<\/strong><\/p>\n<p>\u064a\u064f\u0639\u062f\u0651 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a Rheumatoid arthritis (RA) \u0645\u0631\u0636\u0627\u064b \u0645\u0646\u0627\u0639\u064a\u0627\u064b \u0630\u0627\u062a\u064a\u0627\u064b \u0634\u0627\u0626\u0639\u0627\u064b \u0648\u0645\u0632\u0645\u0646\u0627\u064b\u060c \u064a\u0635\u064a\u0628 \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0632\u0644\u064a\u0644\u064a \u0641\u064a \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0622\u0643\u0644 \u0627\u0644\u0639\u0638\u0627\u0645 \u0648\u062a\u0634\u0648\u0647\u0627\u062a\u064d \u0645\u0641\u0635\u0644\u064a\u0629\u064d \u0645\u0639 \u0645\u0631\u0648\u0631 \u0627\u0644\u0648\u0642\u062a (1). \u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0644\u062a\u0642\u062f\u0645 \u0641\u064a \u0648\u0633\u0627\u0626\u0644 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0648\u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0644\u0627 \u062a\u0632\u0627\u0644 \u0627\u0644\u0622\u0644\u064a\u0629 \u0627\u0644\u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0644\u0645\u0631\u0636 \u063a\u064a\u0631 \u0645\u0641\u0647\u0648\u0645\u0629\u064d \u062a\u0645\u0627\u0645\u0627\u064b (2). \u062a\u0634\u064a\u0631 \u0627\u0644\u0645\u0639\u0637\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0639\u0644\u0649 \u0646\u062d\u0648 \u0645\u062a\u0632\u0627\u064a\u062f \u0625\u0644\u0649 \u0623\u0646\u0651 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u062f\u0648\u0631\u0627\u064b \u064a\u062a\u062c\u0627\u0648\u0632 \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0648\u0627\u0644\u0639\u0638\u0627\u0645\u060c \u0644\u064a\u0634\u0645\u0644 \u062a\u0646\u0638\u064a\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0641\u0637\u0631\u064a\u0629 \u0648\u0627\u0644\u0645\u0643\u062a\u0633\u0628\u0629. \u064a\u064f\u0639\u0628\u0651\u064e\u0631 \u0639\u0646 \u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u00a0(VDR) \u0641\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0628\u0627\u0626\u064a\u0629\u060c \u0648\u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a \u0627\u0644\u0644\u064a\u0641\u064a\u0629 (3). \u0648\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0628\u0639\u0636 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0627\u0644\u062a\u063a\u0627\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u064f\u0631\u0645\u0651\u0650\u0632 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u00a0(VDR)\u0642\u062f \u062a\u0624\u062b\u0631 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0627\u0646\u062a\u0633\u0627\u062e \u0623\u0648 \u0641\u064a \u0628\u0646\u064a\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0623\u0648 \u0648\u0638\u064a\u0641\u062a\u0647\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0633\u0647\u0645 \u0641\u064a \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u064a\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0623\u0645\u0631\u0627\u0636 \u0645\u0646\u0627\u0639\u064a\u0629 \u0645\u062b\u0644 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a (RA) \u00a0(4\u060c 5).<\/p>\n<p>\u064a\u064f\u0639\u062f\u0651 \u0627\u0644\u062a\u0651\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f Taq-I \u0630\u0648 \u0627\u0644\u0631\u0642\u0645 \u0627\u0644\u062a\u0639\u0631\u064a\u0641\u064a (rs731236)\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0642\u0639 \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u062a\u0627\u0633\u0639 \u0644\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0651\u0632 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D (VDR)\u060c \u0623\u062d\u062f \u0627\u0644\u062a\u0651\u0639\u062f\u062f\u0627\u062a \u0627\u0644\u0634\u0651\u0643\u0644\u064a\u0651\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629\u0650 \u0641\u064a \u062c\u064a\u0646 \u0627\u0644\u0640VDR \u060c \u0648\u064a\u064f\u0639\u062a\u0642\u062f \u0623\u0646\u0647 \u064a\u0624\u062b\u0631 \u0641\u064a \u062b\u0628\u0627\u062a\u064a\u0651\u0629 \u0627\u0644\u0645\u0646\u062a\u0633\u062e\u0627\u062a. \u0648\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u062a\u063a\u0627\u064a\u0631 \u0644\u0627 \u064a\u064f\u062d\u062f\u0650\u062b \u062a\u063a\u064a\u064a\u0631\u0627\u064b \u0641\u064a \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0631\u062a\u0628\u0627\u0637\u0647 \u0628\u0623\u0645\u0631\u0627\u0636 \u0645\u0646\u0627\u0639\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0647\u0645\u064a\u062a\u0647 \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 (6\u060c 7).<\/p>\n<p>\u0647\u062f\u0641\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0625\u0644\u0649 \u062a\u062d\u0631\u0651\u064a \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u062a\u0651\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a Taq-1 \u0648\u0627\u062e\u062a\u0637\u0627\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a \u0641\u064a \u062c\u0645\u0647\u0631\u0629\u064d \u0633\u0648\u0631\u064a\u0629\u064d\u060c \u0645\u0639 \u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0627\u0642\u062a\u0647 \u0628\u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636 \u0648\u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D.<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Materials and Methods<\/strong><\/p>\n<p><strong>\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646<\/strong><\/p>\n<p>\u0635\u064f\u0645\u0651\u0645\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u062d\u0627\u0644\u064a\u0651\u0629 \u0644\u062a\u0643\u0648\u0646 \u0631\u0635\u062f\u064a\u0651\u0629 \u0645\u0646 \u0646\u0645\u0637 \u062d\u0627\u0644\u0627\u062a-\u0634\u0648\u0627\u0647\u062f case-control study\u060c \u0648\u062d\u0627\u0632\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u0631\u0642\u0645 \u0627\u0644\u062a\u0639\u0631\u064a\u0641\u064a MD-210-125-21-h23 \u0627\u0644\u0645\u0645\u0646\u0648\u062d\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0644\u062c\u0646\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0651\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642\u060c \u0648\u0623\u062c\u0631\u064a\u062a \u0641\u064a \u0645\u0633\u062a\u0634\u0641\u064a\u064a \u0627\u0644\u0645\u0648\u0627\u0633\u0627\u0629 \u0648\u0627\u0644\u0648\u0637\u0646\u064a \u0627\u0644\u062c\u0627\u0645\u0639\u064a\u064a\u0646 \u0641\u064a \u062f\u0645\u0634\u0642 \u0628\u064a\u0646 \u0634\u0647\u0631\u064a \u0622\u0630\u0627\u0631 \u0648\u062d\u0632\u064a\u0631\u0627\u0646 \u0645\u0646 \u0639\u0627\u0645 2023.<\/p>\n<p>\u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 100 \u0645\u0631\u064a\u0636\u064d \u0628\u0627\u0644\u063a \u064d\u0645\u0634\u062e\u0651\u0635\u064d \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a (RA) \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0635\u0646\u064a\u0641 \u0627\u0644\u0635\u0627\u062f\u0631\u0629 \u0639\u0646 \u0627\u0644\u0643\u0644\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0631\u0648\u0645\u0627\u062a\u064a\u0632\u0645 American College of Rheumatology\/\u0627\u0644\u0631\u0627\u0628\u0637\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0644\u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0631\u0648\u0645\u0627\u062a\u064a\u0632\u0645 European Alliance of Associations for Rheumatology \u0644\u0639\u0627\u0645\u00a0\u00a0 2010(ACR\/EULAR 2010) \u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 100 \u0634\u062e\u0635\u064d \u0633\u0644\u064a\u0645\u064a\u0646 \u0638\u0627\u0647\u0631\u064a\u0627\u064b \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0648\u0645\u0645\u0627\u062b\u0644\u064a\u0646 \u0644\u0644\u0645\u0631\u0636\u0649 \u0645\u0646 \u062d\u064a\u062b \u0627\u0644\u0639\u0645\u0631 \u0648\u0627\u0644\u062c\u0646\u0633. \u0642\u062f\u0651\u0645 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0645\u0648\u0627\u0641\u0642\u0627\u062a\u0647\u0645 \u0627\u0644\u062e\u0637\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0646\u064a\u0631\u0629 \u0642\u0628\u0644 \u0627\u0646\u062e\u0631\u0627\u0637\u0647\u0645 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u062a\u0636\u0645\u0646\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0623\u0647\u0644\u064a\u0629\/\u0627\u0644\u062a\u0651\u0636\u0645\u064a\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0639\u0645\u0631 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u226518 \u0633\u0646\u0629\u060c \u0645\u0639 \u062a\u0639\u0631\u0651\u0636 \u0645\u0646\u062a\u0638\u0645 \u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0634\u0645\u0633 (\u22653 \u0633\u0627\u0639\u0627\u062a\/\u0623\u0633\u0628\u0648\u0639)\u060c \u0648\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062d\u0627\u0644\u0627\u062a\u064d \u0645\u0631\u0636\u064a\u0651\u0629\u064d \u0623\u0648 \u062f\u0648\u0627\u0626\u064a\u0651\u0629\u064d \u0645\u0639\u0631\u0648\u0641\u0629\u064d \u0628\u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0641\u064a \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D.<\/p>\n<p><strong>\u0645\u0642\u0627\u064a\u0633\u0629 \u0648\u062a\u0635\u0646\u064a\u0641 \u062d\u0627\u0644\u0629 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 <\/strong><strong>\u00a0D<\/strong><\/p>\n<p>\u0642\u064a\u0633\u062a \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0627\u0644\u0628\u062f\u0626\u064a\u0651\u0629 \u0644\u0640 25 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0641\u064a\u062a\u0627\u0645\u064a\u0646D \u0627\u0644\u0645\u064f\u0639\u0628\u0631 \u0639\u0646\u0647\u0627 \u0628\u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0641\u0631\u0648\u0644 \u0623\u0648 [25 (OH) D] \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0628\u0627\u0644\u062a\u0623\u0644\u0651\u0642 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a (\u0639\u062a\u064a\u062f\u0629Elecsys\u00ae Vitamin D Total G3 \u060c \u0645\u0646 \u0634\u0631\u0643\u0629 Roche Diagnostics\u060c \u0623\u0644\u0645\u0627\u0646\u064a\u0627)\u060c \u0648\u062c\u0631\u0649 \u062a\u0635\u0646\u064a\u0641 \u062d\u0627\u0644\u0629 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0644\u062f\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0628\u062d\u0633\u0628 \u0627\u0644\u062a\u0651\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0648\u0641\u0642 \u0625\u0631\u0634\u0627\u062f\u0627\u062a \u0645\u0639\u0647\u062f \u0627\u0644\u0637\u0628 Institute of Medicine \u00a0\u00a0(IOM) \u0625\u0644\u0649 \u0627\u0644\u0641\u0626\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629: \u062d\u0627\u0644\u0629 \u0643\u0641\u0627\u064a\u0629 Sufficiency \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D (\u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0623\u0639\u0644\u0649 \u0645\u0646 20 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0644)\u060c \u062d\u0627\u0644 \u0639\u062f\u0645 \u0643\u0641\u0627\u064a\u0629 Insufficiency \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D (\u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0628\u064a\u0646 12-20 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0644)\u060c \u062d\u0627\u0644\u0629 \u0639\u0648\u0632 Deficiency \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D (\u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0627\u0644\u0623\u0642\u0644 \u0645\u0646 12 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0644).<\/p>\n<p><strong>\u062a\u0642\u064a\u064a\u0645 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u0631\u0636 <\/strong><strong>Disease Activity Score-C Reactive Protein<\/strong> <strong>DAS28-CRP)<\/strong><strong>)<\/strong><\/p>\n<p>\u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a \u00a0RA\u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u064a\u0627\u0633 \u0641\u0639\u0651\u0627\u0644\u064a\u0629\/\u0646\u0634\u0627\u0637 \u0627\u0644\u0645\u0631\u0636 \u0641\u064a 28 \u0645\u0641\u0635\u0644\u064b\u0627 \u0645\u0639 \u0642\u064a\u0645\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0627\u0631\u062a\u0643\u0627\u0633\u064a C (DAS28-CRP). \u0642\u064a\u0633\u062a \u062a\u0631\u0627\u0643\u064a\u0632 CRP \u0641\u064a \u0627\u0644\u0645\u0635\u0644 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u062a\u064a\u062f\u0629 Tina-quant C-Reactive Protein IV \u00a0\u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062c\u0647\u0627\u0632 COBAS INTEGRA\/COBAS\u060c \u0645\u0646\u00a0 \u0634\u0631\u0643\u0629 Roche Diagnostics\u060c \u0623\u0644\u0645\u0627\u0646\u064a\u0627. \u0639\u064f\u062f\u0651\u062a \u062a\u0631\u0627\u0643\u064a\u06320.5&gt; CRP \u00a0\u0645\u063a\/\u062f\u0644 \u0636\u0645\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0651\u0629\u060c \u0648\u0642\u062f \u0641\u064f\u0633\u0651\u0631\u062a \u0646\u062a\u0627\u0626\u062c DAS28-CRP \u0648\u0642\u064f\u064a\u0651\u0645 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0645\u0648\u062c\u0628\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u0646\u0651\u062d\u0648 \u0627\u0644\u062a\u0651\u0627\u0644\u064a:<\/p>\n<ul>\n<li>\u0646\u0634\u0627\u0637 \u0645\u0631\u0636\u064a \u0645\u0631\u062a\u0641\u0639 \u0644\u0642\u064a\u0645 1&lt; DAS<\/li>\n<li>\u0646\u0634\u0627\u0637 \u0645\u062a\u0648\u0633\u0637 \u0644\u0642\u064a\u0645 DAS \u062a\u0642\u0639 \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 \u0645\u0646 3.2 \u0648\u062d\u062a\u0649 5.1.<\/li>\n<li>\u0646\u0634\u0627\u0637 \u0645\u0646\u062e\u0641\u0636 \u0644\u0642\u064a\u0645 DAS \u22642.<\/li>\n<\/ul>\n<p><strong>\u0627\u0633\u062a\u0639\u0631\u0627\u0641 \u0627\u0644\u0623\u0644\u0627\u0626\u0644 \u0648\u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a <\/strong>Genotyping<\/p>\n<p>\u0628\u064f\u0632\u0644\u062a \u0639\u064a\u0646\u0627\u062a\u064f \u062f\u0645 \u064d\u0648\u0631\u064a\u062f\u064a\u0651\u064d \u0645\u062d\u064a\u0637\u064a\u0651\u064d \u0628\u062d\u062c\u0645 3 \u0645\u0644 \u0639\u0644\u0649 \u0623\u0646\u0628\u0648\u0628 \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0645\u0636\u0627\u062f\u064d \u0627\u0644\u062a\u062e\u062b\u0631 \u0627\u064a\u062a\u064a\u0644\u0646 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0623\u0645\u064a\u0646 \u0631\u0628\u0627\u0639\u064a \u0627\u0644\u062e\u0644\u0627\u062a Ethylenediamine Tetraacetic Acid (EDTA)\u060c \u0648\u062d\u064f\u0641\u0638\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0645\u064f\u0639\u0646\u0648\u0646\u0629 \u0648\u0645\u064f\u062c\u0645\u0651\u062f\u0629 \u0628\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 -20 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629 \u0641\u064a \u0645\u062e\u0628\u0631 \u0627\u0644\u062a\u0642\u0627\u0646\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0651\u0629 \u0627\u0644\u0635\u0651\u064a\u062f\u0644\u0627\u0646\u064a\u0651\u0629 \u0648\u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0641\u064a \u0627\u0644\u0647\u064a\u0626\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u062a\u0651\u0642\u0627\u0646\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0644\u062d\u064a\u0646 \u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0651\u0648\u0648\u064a \u0627\u0644\u0631\u0651\u064a\u0628\u0648\u0632\u064a \u0645\u0646\u0642\u0648\u0635 \u0627\u0644\u0623\u0648\u0643\u0633\u062c\u064a\u0646 Deoxyribonucleic Acid (DNA). \u0623\u064f\u0630\u064a\u0628\u062a \u0627\u0644\u0639\u064a\u0651\u0646\u0627\u062a \u0627\u0644\u062f\u0645\u0648\u064a\u0651\u0629 \u0627\u0644\u0645\u062c\u0645\u0651\u062f\u0629 \u0648\u0645\u0646 \u062b\u0645 \u0627\u0633\u062a\u064f\u062e\u0644\u0635 \u0627\u0644\u0640 DNA \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u062a\u064a\u062f\u0629 \u062a\u0646\u0642\u064a\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0645\u0646 Jena Bioscience\u060c \u0623\u0644\u0645\u0627\u0646\u064a\u0627\u060c \u0645\u0646 \u062d\u062c\u0645 \u062f\u0645 \u0642\u062f\u0631\u0647 300 \u0645\u0643\u0644 \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u062a\u0639\u0644\u064a\u0645\u0627\u062a \u0627\u0644\u0645\u0631\u0641\u0642\u0629 \u0628\u0639\u062a\u064a\u062f\u0629 \u0627\u0644\u0639\u0632\u0644 \u0645\u0646 \u0627\u0644\u0634\u0651\u0631\u0643\u0629 \u0627\u0644\u0645\u0635\u0646\u0651\u0639\u0629. \u0648\u0642\u064a\u0633\u062a \u062a\u0631\u0627\u0643\u064a\u0632\u0647 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0637\u064a\u0641\u064aMaestro-Nano\u00ae Pro MaestroGen\u00ae\u060c \u062a\u0627\u064a\u0648\u0627\u0646. \u0648\u0627\u0639\u062a\u064f\u0645\u062f\u062a \u0627\u0644\u0640\u0642\u064a\u0645 \u0627\u0644\u0640\u062a\u064a \u062a\u062a\u0631\u0627\u0648\u062d \u0645\u0646 1.7 \u0627\u0644\u0640\u0649 4.0 \u0645\u0646\u0633\u0628\u0627\u064b \u062c\u064a\u062f\u0627\u064b \u0644\u0644\u0646\u0642\u0627\u0648\u0629 \u0648\u0628\u0644\u063a \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a (A260\/280 ~1.86).<\/p>\n<p><strong>\u0627\u0644\u062a\u0641\u0627\u0639\u0644 <\/strong><strong>\u0627\u0644\u062a\u0651\u0633\u0644\u0633\u064f\u0644\u064a\u0651 <\/strong><strong>\u0644\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 <\/strong><strong>Polymerase Chain Reaction<\/strong><strong> (<\/strong><strong>PCR<\/strong><strong>) \u0648\u0627\u0644\u0633\u0644\u0633\u0644\u0629 <\/strong><strong>Sequencing<\/strong><\/p>\n<p>\u0642\u0645\u0646\u0627 \u0623\u0648\u0644\u0627\u064b \u0628\u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a Taq-I \u0641\u064a \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0632 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0641\u064a \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u0643\u0632 \u0627\u0644\u0648\u0637\u0646\u064a \u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u062a\u0642\u0627\u0646\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629National Institute for Biotechnology Information (NCBI) \u0627\u0644\u062e\u0627\u0635\u0651\u0629 \u0628\u0627\u0644\u062a\u0651\u0639\u062f\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0651\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0631\u0642\u0645 \u0627\u0644\u062a\u0639\u0631\u064a\u0641 rs731236 \u0627\u0644\u062e\u0627\u0635 \u0628\u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0627\u0644\u0645\u062f\u0631\u0648\u0633. \u0648\u062d\u062f\u0651\u062f \u0645\u0648\u0636\u0639 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0628\u0634\u0631\u064a\u060c \u0642\u0645\u0646\u0627 \u0628\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0645\u0631\u0626\u0633\u064a\u0646 \u0627\u0644\u062a\u0651\u0642\u062f\u0651\u0645\u064a \u0648\u0627\u0644\u0639\u0643\u0633\u064a \u0627\u0644\u062a\u0651\u0627\u0644\u064a\u064a\u0646:<\/p>\n<ul>\n<li>\u0627\u0644\u062a\u0633\u0644\u0633\u0644 5`-AGGTCGGCTAGCTTCTGGAT-3` \u0643\u0645\u0634\u0631\u0639 \u062a\u0642\u062f\u0645\u064a Forward Primer<\/li>\n<li>\u0627\u0644\u062a\u0651\u0633\u0644\u0633\u0644 5`-CAGTGGTATCACCGGTCAGC-3` \u0643\u0645\u0634\u0631\u0639 \u0639\u0643\u0633\u064aReverse Primer<\/li>\n<\/ul>\n<p>\u0648\u062a\u0645 \u0627\u0644\u062a\u0651\u0623\u0643\u062f \u0645\u0646 \u0646\u0648\u0639\u064a\u0629 \u0647\u0630\u064a\u0646 \u0627\u0644\u0645\u0634\u0631\u0639\u064a\u0646 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0623\u062f\u0627\u0629 MFEprimer \u0648\u062c\u0631\u062a \u0623\u0645\u062b\u0644\u0629 in silico \u0644\u0634\u0631\u0648\u0637 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u062a\u0651\u0633\u0644\u0633\u064f\u0644\u064a\u0651 PCR \u0648\u0627\u0644\u062a\u064a \u0623\u0641\u0636\u062a \u0625\u0644\u0649 \u0645\u0646\u062a\u062c\u064d \u0646\u0648\u0639\u064a\u0651\u064d \u0628\u0627\u0644\u0637\u0648\u0644 \u0627\u0644\u0645\u062a\u0648\u0642\u0651\u0639 ~292 \u0632\u0648\u062c\u0650 \u0623\u0633\u0627\u0633\u064d.<\/p>\n<p>\u0623\u062c\u0631\u064a\u062a \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0640 PCR \u0644\u062a\u0636\u062e\u064a\u0645 \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0640 DNA \u0627\u0644\u0645\u062a\u0636\u0645\u0646\u0629 \u0644\u0640 SNP \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u060c \u062d\u064a\u062b \u0628\u0644\u063a \u062d\u062c\u0645 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0643\u0644\u0651\u064a 20 \u0645\u0643\u0644\u060c \u0648\u0627\u062d\u062a\u0648\u0649 \u0645\u0632\u064a\u062c \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0639\u0644\u0649 \u0645\u0627 \u064a\u0644\u064a: 200 \u00a0\u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a\u060c 1 \u00a0\u0645\u064a\u0643\u0631\u0648\u0644\u064a\u062a\u0631 \u0645\u0646 \u0643\u0644 \u0645\u0631\u0626\u0633 (\u0628\u062a\u0631\u0643\u064a\u0632 10 \u0628\u064a\u0643\u0648\u0645\u0648\u0644)\u060c 10 \u00a0\u0645\u064a\u0643\u0631\u0648\u0644\u064a\u062a\u0631 \u0645\u0646 \u0645\u0632\u064a\u062c GeneDireX\u00ae One PCR\u2122 Master Mix \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0625\u0646\u0632\u064a\u0645Taq Polymerase \u060c \u0648\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u060c \u0648\u0635\u0628\u063a\u0629 \u0627\u0644\u0647\u0644\u0627\u0645\u060c \u0648\u0635\u0628\u063a\u0629 \u0641\u0644\u0648\u0631\u064a\u0629\u060c \u0648\u0623\u064f\u0643\u0645\u0644 \u0627\u0644\u062d\u062c\u0645 \u0627\u0644\u0646\u0647\u0627\u0626\u064a \u0625\u0644\u0649 20 \u0645\u064a\u0643\u0631\u0648\u0644\u064a\u062a\u0631 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0627\u0621 \u0645\u0646\u0632\u0648\u0639 \u0627\u0644\u0623\u064a\u0648\u0646\u0627\u062a \u0648\u0639\u0642\u064a\u0645. \u0623\u064f\u062c\u0631\u064a \u062a\u0641\u0627\u0639\u0644 PCR \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u062f\u0648\u0631 \u0627\u0644\u062d\u0631\u0627\u0631\u064a Senso-Quest \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u0645\u0648\u0636\u0651\u062d\u0629 \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 1.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-2176 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/1-3-300x167.png\" alt=\"\" width=\"300\" height=\"167\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/1-3-300x167.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/1-3.png 436w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>\u062a\u0645 \u062a\u0638\u0647\u064a\u0631 \u0645\u0646\u062a\u062c\u0627\u062a PCR \u0628\u062a\u0631\u062d\u064a\u0644\u0647\u0627 \u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0651\u0627\u064b \u0641\u064a \u0647\u0644\u0627\u0645 \u0627\u0644\u0623\u063a\u0627\u0631\u0648\u0632 \u0628\u0639\u062f \u062a\u0639\u0631\u064a\u0636\u0647\u0627 \u0644\u0644\u0623\u0634\u0639\u0629 \u0641\u0648\u0642 \u0627\u0644\u0628\u0646\u0641\u0633\u062c\u064a\u0651\u0629\u060c \u062b\u0645 \u0646\u064f\u0642\u0651\u064a\u062a \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0644\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u062b\u0646\u0627\u0626\u064a\u0629 \u0627\u0644\u0627\u062a\u062c\u0627\u0647 \u0628\u0637\u0631\u064a\u0642\u0629 \u0633\u0627\u0646\u063a\u0631 \u0641\u064a \u0634\u0631\u0643\u0629Macrogen\u00a0\u00a0 \u0627\u0644\u0643\u0648\u0631\u064a\u0651\u0629 \u0627\u0644\u062c\u0646\u0648\u0628\u064a\u0651\u0629\u060c \u0648\u0642\u0631\u0626\u062a \u0627\u0644\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628\u064a\u0629 chromatograms \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0645\u062c\u064a\u0651\u0629 SnapGene\u00ae.<\/p>\n<p><strong>\u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629<\/strong><\/p>\n<p>\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c SPSS \u0627\u0644\u0625\u0635\u062f\u0627\u0631 26. \u0642\u0648\u0631\u0646\u062a \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0641\u0626\u0648\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u062a\u0631\u0628\u064a\u0639 (Chi-square)\u060c \u0648\u0639\u064f\u0631\u0636\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0639\u0644\u0649 \u0634\u0643\u0644 \u062a\u0643\u0631\u0627\u0631\u0627\u062a \u0648\u0646\u0633\u0628 \u0645\u0626\u0648\u064a\u0629. \u0623\u0645\u0627 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0629 \u0641\u0642\u062f \u062a\u0645 \u062a\u062d\u0644\u064a\u0644\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631\u064a \u0645\u0627\u0646\u2013\u0648\u064a\u062a\u0646\u064a Mann\u2013Whitney U\u00a0 \u0648\u0643\u0631\u0648\u0633\u0643\u0627\u0644\u2013\u0648\u0627\u0644\u064a\u0633 Kruskal\u2013Wallis\u060c \u062d\u0633\u0628 \u0627\u0644\u0627\u0642\u062a\u0636\u0627\u0621. \u062a\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u0644\u062a\u0648\u0627\u0632\u0646 \u0627\u0644\u0648\u0631\u0627\u062b\u064a \u0648\u0641\u0642 \u0642\u0627\u0646\u0648\u0646 \u0647\u0627\u0631\u062f\u064a\u2013\u0648\u0627\u064a\u0646\u0628\u0631\u063a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u0643\u0627\u064a \u062a\u0631\u0628\u064a\u0639. \u0643\u0645\u0627 \u062d\u064f\u0633\u0628\u062a \u0646\u0633\u0628 \u0627\u0644\u0623\u0631\u062c\u062d\u064a\u0629 (ORs) Odds Ratios \u0645\u0639 \u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u062b\u0642\u0629 95% (%95(CIs\u00a0 \u0644\u062a\u0642\u062f\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a \u0627\u0644\u0645\u062f\u0631\u0648\u0633 \u0648\u062e\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a (RA).<\/p>\n<p><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c <\/strong><strong>Results<\/strong><\/p>\n<p><strong>\u0627\u0644\u0633\u0645\u0627\u062a \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u0645\u062a\u062b\u0628\u062a\u0627\u062a \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646<\/strong><\/p>\n<p>\u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u0623\u0639\u0645\u0627\u0631 \u0645\u0631\u0636\u0649 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a (RA) \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u0629 \u0645\u062a\u0642\u0627\u0631\u0628\u0627\u064b (46.03 \u00b111.29 \u0645\u0642\u0627\u0628\u0644 45.68 \u00b111.23 \u0639\u0627\u0645\u0627\u064b)\u060c (p= 0.826). \u0648\u0643\u0627\u0646 \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0641\u0626\u0627\u062a \u0627\u0644\u0639\u0645\u0631\u064a\u0629 \u0634\u0628\u0647 \u0645\u062a\u0637\u0627\u0628\u0642 (p= 0.985). \u0643\u0645\u0627 \u0643\u0627\u0646 \u062a\u0648\u0632\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0628\u064a\u0646 \u0627\u0644\u062c\u0646\u0633\u064a\u0646 \u0645\u062a\u0648\u0627\u0632\u0646\u0627\u064b\u060c \u0645\u0639 \u063a\u0644\u0628\u0629 \u0644\u0644\u0625\u0646\u0627\u062b \u0641\u064a \u0643\u0644\u062a\u0627 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 (85% \u0645\u0642\u0627\u0628\u0644 83%)(p= 0.700) . \u0643\u0627\u0646 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u0644\u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (BMI) \u0645\u062a\u0645\u0627\u062b\u0644\u0627\u064b \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0640 RA \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 (24.67 \u00b13.76 \u0645\u0642\u0627\u0628\u0644 24.96 \u00b13.24 \u0643\u063a\/\u0645\u00b2) .(p= 0.564)<\/p>\n<p>\u0644\u0645 \u064a\u0633\u062c\u0644 \u0641\u0631\u0642\u064c \u064a\u064f\u0630\u0643\u0631 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0641\u064a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0644\u0628\u0627\u0633 \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u060c \u0627\u0644\u0630\u064a \u0642\u062f \u064a\u0624\u062b\u0651\u0631 \u0641\u064a \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0634\u0645\u0633\u060c \u062d\u064a\u062b \u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0633\u064a\u0651\u062f\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u062f\u064a\u0627\u062a \u0644\u0644\u062d\u062c\u0627\u0628 84.5% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0640 RA \u0645\u0642\u0627\u0628\u0644 75.9% \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u0629\u061bp= 0.162) ). \u0643\u0630\u0644\u0643\u060c \u0643\u0627\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0648\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0634\u0645\u0633 \u0646\u0627\u062f\u0631\u0627\u064b \u0648\u0645\u062a\u0642\u0627\u0631\u0628\u0627\u064b \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 (5% \u0645\u0642\u0627\u0628\u0644 11%\u061bp= 0.118 ). \u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u062d\u0631\u0632 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0634\u0645\u0633 \u0623\u0633\u0628\u0648\u0639\u064a\u0651\u0627\u064b \u0623\u0639\u0644\u0649 \u0642\u0644\u064a\u0644\u064b\u0627 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 (5.45\u00b1 15.80)\u00a0 \u0645\u0642\u0627\u0628\u0644 15.26\u00b15.30 \u0633\u0627\u0639\u0629\u061bp= 0.478) ). \u0644\u0648\u062d\u0638 \u0648\u062c\u0648\u062f \u0641\u0627\u0631\u0642 \u062c\u0644\u064a\u0651\u064d \u0641\u064a \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u0625\u0630 \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646 \u0623\u0642\u0644 \u0628\u0634\u0643\u0644\u064d \u0645\u0644\u062d\u0648\u0638\u064d \u0628\u064a\u0646 \u0645\u0631\u0636\u0649 \u0627\u0644\u0640 (22%) RA \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0634\u0651\u0627\u0647\u062f\u0629 (67%)\u060c .(p= 0.001)<\/p>\n<p>\u0644\u062f\u0649 \u062a\u0642\u064a\u064a\u0645 \u0641\u0639\u0651\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u0631\u0636 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0627\u062a (\u0645\u0631\u0636\u0649 \u0627\u0644\u0640 (RA\u060c \u062a\u0628\u064a\u0651\u0646 \u0623\u0646\u0651 15% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0641\u0639\u0651\u0627\u0644\u064a\u0629\u064d\/\u0646\u0634\u0627\u0637\u064d \u0645\u0631\u062a\u0641\u0639\u064d \u0644\u0644\u0645\u0631\u0636 (DAS28-CRP &gt; 5.1)\u060c \u0648\u0623\u0641\u0627\u062f\u062a \u0646\u0633\u0628\u0629\u064c \u062a\u0646\u0627\u0647\u0632 \u0627\u0644\u0646\u0651\u0635\u0641 51% \u0645\u0646\u0647\u0645 \u0628\u062a\u0634\u062e\u064a\u0635 \u0645\u0628\u0643\u0631 \u0644\u0644\u0645\u0631\u0636 \u0642\u0628\u0644 \u0633\u0646 \u0627\u0644\u0623\u0631\u0628\u0639\u064a\u0646. \u0643\u0627\u0646 \u0627\u0644\u0645\u064a\u062b\u0648\u062a\u0631\u0643\u0633\u0627\u062a \u062c\u0632\u0621\u0627\u064b \u0645\u0646 \u0627\u0644\u062e\u0637\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u062f\u0649 67% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649.<\/p>\n<p>\u062a\u062e\u0637\u062a \u0646\u0633\u0628\u0629 \u062a\u0646\u0627\u0648\u0644 \u0645\u062a\u0645\u0645\u0627\u062a \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0627\u0644\u0641\u0645\u0648\u064a\u0651\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0642\u0628\u0644 \u0627\u0646\u062e\u0631\u0627\u0637\u0647\u0645 \u0641\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 41% \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0646\u0633\u0628\u0629\u064d \u0644\u0645 \u062a\u062a\u062c\u0627\u0648\u0632 18% \u0644\u062f\u0649 \u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c p= 0.001)). \u0648\u0643\u0627\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0623\u0643\u062b\u0631 \u062a\u0646\u0627\u0648\u0644\u0627\u064b \u0644\u062c\u0631\u0639\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0629 \u0645\u0646 \u0645\u062a\u0645\u0645\u0627\u062a \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D (10,000 \u0648\u062d\u062f\u0629\/\u0623\u0633\u0628\u0648\u0639 \u0623\u0648 20,000\u201350,000 \u0648\u062d\u062f\u0629\/\u0623\u0633\u0628\u0648\u0639)\u060c p= 0.006)). \u0648\u0623\u0638\u0647\u0631 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0643\u0627\u0646\u0648\u0627 \u064a\u062a\u0646\u0627\u0648\u0644\u0648\u0646 \u0645\u062a\u0645\u0645\u0627\u062a \u0641\u0645\u0648\u064a\u0651\u0629 \u0645\u0646 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0642\u0628\u0644 \u0627\u0644\u0627\u0646\u062e\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u0635\u0644\u064a\u0651\u0629 \u0623\u0639\u0644\u0649 \u0645\u0646 25(OH)D \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0623\u0642\u0631\u0627\u0646\u0647\u0645 \u0645\u0645\u0646 \u0644\u0645 \u064a\u062a\u0644\u0642\u0648\u0627 \u0645\u062a\u0645\u0645\u0627\u062a \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D\u060c \u0648\u0643\u0627\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0630\u0627 \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629\u064d \u0643\u0628\u064a\u0631\u0629\u064d (p= 0.004). \u063a\u064a\u0631 \u0623\u0646\u0651 \u0646\u0633\u0628 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0639\u0648\u0632 \u0623\u0648 \u0646\u0642\u0635 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0643\u0627\u0646\u062a \u0623\u0639\u0644\u0649 \u0628\u0634\u0643\u0644\u064d \u0639\u0627\u0645 \u0644\u062f\u0649 \u0645\u062c\u0645\u0644 \u0645\u0631\u0636\u0649 RA \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0634\u0648\u0627\u0647\u062f (50% \u0645\u0642\u0627\u0628\u0644 35%)\u061b(p= 0.005) \u060c \u0643\u0645\u0627 \u0623\u0628\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u062a\u0631\u0627\u0643\u064a\u0632 \u0645\u0635\u0644\u064a\u0629 \u0623\u0642\u0644 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0645\u0646 25(OH)D 22.38)\u00a0\u00a0 15.80\u00b1\u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0644) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f (27.56 \u00b113.04 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0644)\u060c\u00a0 .(p= 0.036)<\/p>\n<p><strong>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a<\/strong><\/p>\n<p>\u0646\u062c\u062d\u0646\u0627 \u0641\u064a \u0627\u0644\u062a\u0651\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0640 97 \u0645\u0631\u064a\u0636\u0627\u064b \u064897 \u0634\u0627\u0647\u062f\u0627\u064b. \u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u0634\u0643\u0644 1 \u0623\u0645\u062b\u0644\u0629\u064b \u0639\u0646 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0636\u062e\u064a\u0645 \u0642\u0637\u0639\u0629 \u0627\u0644\u0640DNA\u00a0\u00a0 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0645\u0631\u062d\u0644\u0629\u064b \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0627\u0644\u0623\u063a\u0627\u0631\u0648\u0632 (\u0627\u0644\u0634\u0651\u0643\u0644 1. A)\u060c \u0648\u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0644\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a Taq-I (\u0627\u0644\u0634\u0651\u0643\u0644 1. A\u060cB \u060cC ). \u0644\u062f\u0649 \u0645\u0642\u0627\u0631\u0646\u0629 \u0646\u0633\u0628 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0644\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064a Taq-I \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0623\u0635\u062d\u0627\u0621\u060c \u0644\u0648\u062d\u0638 \u062a\u0628\u0627\u064a\u0646\u064c \u0641\u064a \u0646\u0633\u0628 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631\u061b \u062d\u064a\u062b \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a ((AA \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 25.8% \u0645\u0642\u0627\u0628\u0644 59.8% \u0644\u062f\u0649 \u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c \u0641\u064a \u062d\u064a\u0646 \u0628\u0644\u063a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a ((AG \u0646\u0633\u0628\u0629 63.9% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0642\u062a\u0635\u0631 \u0639\u0644\u0649 26.8% \u0645\u0646 \u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c \u0623\u0645\u0627 \u0627\u0644\u0646\u0645\u0637 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0644\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0637\u0627\u0641\u0631 (GG) \u0641\u0643\u0627\u0646 \u062a\u0648\u0627\u062a\u0631\u0647 \u0645\u062a\u0642\u0627\u0631\u0628\u0627\u064b \u0641\u064a \u0643\u0644\u062a\u0627 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 (10.3%) \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f (13.4%)\u060c \u0648\u0643\u0627\u0646\u062a \u0627\u0644\u0641\u0631\u0648\u0642\u0627\u062a \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0641\u064a \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651\u0629 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0645\u0639\u062a\u062f\u0651\u0627\u064b \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (0.0001p=).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2177 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/2-3-300x122.png\" alt=\"\" width=\"359\" height=\"146\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/2-3-300x122.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/2-3.png 752w\" sizes=\"auto, (max-width: 359px) 100vw, 359px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2178 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/3-3-300x231.png\" alt=\"\" width=\"332\" height=\"256\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/3-3-300x231.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/3-3.png 642w\" sizes=\"auto, (max-width: 332px) 100vw, 332px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u0627\u0644\u0634\u0643\u0644 (1): \u0635\u0648\u0631\u0629 \u0645\u0645\u062b\u0644\u0629 \u0644\u062a\u0631\u062d\u064a\u0644 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u0645\u062a\u0633\u0644\u0633\u0644 (PCR) \u0639\u0644\u0649 \u0647\u0644\u0627\u0645\u0629 \u0623\u063a\u0627\u0631\u0648\u0632 (\u062a\u0631\u0643\u064a\u0632 1.5%) (A)\u060c \u062d\u064a\u062b \u062a\u0638\u0647\u0631 \u0639\u0635\u0627\u0628\u0629 \u0648\u062d\u064a\u062f\u0629 \u0628\u0627\u0644\u0637\u0648\u0644 \u0627\u0644\u0645\u062a\u0648\u0642\u0651\u0639 292 \u0632\u0648\u062c \u0623\u0633\u0627\u0633 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0633\u0644\u0645 \u0639\u064a\u0627\u0631\u064a\u0651\u0627\u062a (100 \u0632\u0648\u062c \u0623\u0633\u0627\u0633) \u0644\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0645\u0646\u0642\u0648\u0635 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0627\u0644\u0640DNA. \u0627\u0644\u0645\u062e\u0637\u0637\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628\u064a\u0629 Chromatograms \u0644\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u0640DNA \u0641\u064a \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f Taq-I (rs731236) \u0641\u064a \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0632\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D\u060c \u062d\u064a\u062b \u064a\u0645\u062b\u0644 \u0627\u0644\u0645\u062e\u0637\u0637 B \u0645\u062b\u0627\u0644\u0627\u064b \u0639\u0646 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0651 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0644\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0634\u0651\u0627\u0626\u0639 (AA)\u060c \u0648\u064a\u0645\u062b\u0651\u0644 \u0627\u0644\u0645\u062e\u0637\u0637 C \u0645\u062b\u0627\u0644\u0627\u064b \u0644\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u062e\u0627\u0644\u0641 \u0627\u0644\u0632\u064a\u062c\u0648\u062a (\u0650AG)\u060c \u0641\u064a \u062d\u064a\u0646 \u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u0645\u062e\u0637\u0637 D \u0645\u062b\u0627\u0644\u0627\u064b \u0644\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0632\u064a\u062c\u0648\u062a \u0644\u0644\u0623\u0644\u064a\u0644 \u0627\u0644\u0645\u062a\u063a\u0627\u064a\u0631 (GG).<\/strong><\/p>\n<p>\u0642\u064f\u0648\u0631\u0646\u062a \u062a\u0648\u0627\u062a\u0631\u0627\u062a \u0623\u0644\u064a\u0644\u064a \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0645\u0641\u0631\u062f \u0627\u0644\u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f Taq-I \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0648\u0628\u0631\u0632 \u062a\u0628\u0627\u064a\u0646 \u0648\u0627\u0636\u062d \u0641\u064a \u0646\u0633\u0628 \u062a\u0648\u0627\u062a\u0631\u0647\u0645\u0627\u060c \u062d\u064a\u062b \u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 A 57.7% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0642\u0627\u0628\u0644 73.2% \u0644\u062f\u0649 \u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c \u0648\u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644 G (\u0627\u0644\u0645\u0631\u0636\u0649 42.3%\/\u0627\u0644\u0634\u0648\u0627\u0647\u062f 26.8%). \u0648\u0643\u0627\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0641\u064a \u062a\u0648\u0627\u062a\u0631 \u0627\u0644\u0623\u0644\u064a\u0644\u064a\u0646 \u0630\u0627 \u062f\u0644\u0627\u0644\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0629\u064d (p= 0.001) \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0627\u062e\u062a\u0628\u0627\u0631Pearson Chi-Square .<\/p>\n<p>\u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629 \u0645\u0646\u0633\u0628 \u0627\u0644\u0623\u0631\u062c\u062d\u064a\u0629(OR)\u00a0 \u0644\u0644\u0623\u0644\u064a\u0644 A OR= 0.50))\u060c \u0623\u064a \u0623\u0646 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0644\u064a\u0644 A (\u0627\u0644\u0633\u0627\u0626\u062f) \u064a\u0631\u062a\u0628\u0637 \u0628\u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0648\u0642\u0648\u0639 \u0627\u0644\u0645\u0631\u0636 \u0628\u0646\u0633\u0628\u0629 50%\u060c \u0648\u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629 \u0645\u0646\u0633\u0628 \u0627\u0644\u0623\u0631\u062c\u062d\u064a\u0651\u0629 2 \u0644\u0644\u0623\u0644\u064a\u0644 G (OR= 2)\u060c \u0623\u064a \u0623\u0646 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0644\u064a\u0644 G (\u0627\u0644\u0645\u062a\u063a\u0627\u064a\u0631) \u064a\u0632\u064a\u062f \u0645\u0646 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u0631\u0636 \u0628\u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u0636\u0639\u0641\u060c \u064a\u064f\u0628\u064a\u0646 \u0627\u0644\u062c\u062f\u0648\u0644 2 \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u062a\u0648\u0627\u062a\u0631 \u0623\u0644\u064a\u0644\u064a \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0627\u0644\u0640Taq-I<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2179 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/4-3-300x148.png\" alt=\"\" width=\"482\" height=\"238\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/4-3-300x148.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/4-3-768x379.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/4-3.png 936w\" sizes=\"auto, (max-width: 482px) 100vw, 482px\" \/><\/p>\n<p>\u0623\u062c\u0631\u064a \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0627\u0646\u062d\u062f\u0627\u0631 \u0648\u0641\u0642 \u0646\u0645\u0648\u0630\u062c\u064a \u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u0633\u0627\u0626\u062f \u0648\u0627\u0644\u0645\u062a\u0646\u062d\u064a \u0644\u0623\u0644\u064a\u0644\u064a \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a \u0640Taq-I\u060c \u0648\u0628\u064a\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u062c\u0648\u062f \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f\u060c \u0645\u0645\u0627 \u064a\u064f\u0634\u064a\u0631 \u0627\u0644\u0649 \u0627\u0631\u062a\u0628\u0627\u0637 \u0647\u0630\u0627 \u0627\u0644\u0640 SNP \u0628\u0627\u0644\u0645\u0631\u0636. \u0648\u0623\u0634\u0627\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0649 \u0623\u0646\u0651 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u0644\u064a\u0644 G \u064a\u0631\u062a\u0628\u0637 \u0628\u0632\u064a\u0627\u062f\u0629 \u062e\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0640\u0640RA \u0628\u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u0636\u0639\u0641 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0623\u0644\u064a\u0644 A. \u0643\u0645\u0627 \u0623\u0638\u0647\u0631 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0623\u0646 \u0648\u062c\u0648\u062f \u0623\u0644\u064a\u0644 G \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 (\u0623\u064a \u0627\u0644\u0646\u0651\u0645\u0637\u064a\u0646 \u0633\u0648\u0627\u0621\u064b GG \u0623\u0645 GA) \u064a\u0632\u064a\u062f \u0645\u0646 \u062e\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0640\u0627\u0644\u0640 RA \u0628\u0645\u0642\u062f\u0627\u0631 4.28 \u0645\u0631\u0629 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a AA\u060c \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u062a\u0623\u062b\u064a\u0631\u064d \u0633\u0627\u0626\u062f\u064d \u0642\u0648\u064a\u0651\u064d \u0644\u0644\u0623\u0644\u064a\u0644 G \u0645\u0645\u0651\u0627 \u064a\u0631\u062c\u0651\u062d \u062f\u0648\u0631\u0647 \u0643\u0639\u0627\u0645\u0644 \u062e\u0637\u0648\u0631\u0629 \u062d\u062a\u0649 \u0644\u062f\u0649 \u0627\u0645\u062a\u0644\u0627\u0643 \u0627\u0644\u0641\u0631\u062f \u0644\u0647 \u0628\u0646\u0633\u062e\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u062d\u0633\u0628. \u064a\u064f\u0644\u062e\u0651\u0635 \u0627\u0644\u062c\u062f\u0648\u0644 3 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2180 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/5-3-300x118.png\" alt=\"\" width=\"417\" height=\"164\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/5-3-300x118.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/5-3-768x302.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/5-3.png 882w\" sizes=\"auto, (max-width: 417px) 100vw, 417px\" \/><\/p>\n<p>\u0644\u0645 \u064a\u064f\u0638\u0647\u0631 \u0627\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0643\u0644\u064a Taq-I (\u0633\u0648\u0627\u0621\u064b \u0641\u064a \u062a\u0648\u0632\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0623\u0648 \u0627\u0644\u0623\u0644\u0627\u0626\u0644) \u0627\u0631\u062a\u0628\u0627\u0637\u0627\u064b \u0645\u0639 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D (p=0.149)\u060c \u0644\u0643\u0646\u060c \u0643\u0627\u0646 \u062c\u062f\u064a\u0631\u0627\u064b \u0628\u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0646\u0651\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a AA \u0628\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0651\u0629 \u0623\u0639\u0644\u0649 \u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0642\u064a\u0645\u0629 \u062d\u0631\u0632 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u0631\u0636 DAS28-CRP \u00a0\u0628\u0645\u0642\u062f\u0627\u0631 16 \u0636\u0639\u0641\u0627\u064b \u0648\u0628\u062f\u0644\u0627\u0644\u0629\u064d \u0647\u0627\u0645\u0629\u064d \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (p=0.022). \u0648\u0645\u0646 \u062c\u0647\u0629 \u0623\u062e\u0631\u0649\u060c \u0644\u0645 \u064a\u0643\u0646 \u0644\u0643\u0644\u0651 \u0645\u0646 \u0627\u0644\u0642\u0635\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a\u0629 \u0644\u0644\u0633\u0643\u0631\u064a \u0623\u0648 \u0639\u0645\u0631 \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u0631\u0636\u060c \u0623\u0648 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u064a\u062b\u0648\u062a\u0631\u0643\u0633\u0627\u062a \u0636\u0645\u0646 \u0627\u0644\u062e\u0637\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629\u060c \u062a\u0623\u062b\u064a\u0631\u064c \u064a\u0630\u0643\u0631\u064c \u0639\u0644\u0649 \u0627\u0644\u0645\u062d\u0635\u0644\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649.<\/p>\n<p><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong><strong>Discussion<\/strong><\/p>\n<p>\u0623\u062c\u0631\u064a\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0631\u0651\u0635\u062f\u064a\u0629 \u0645\u0646 \u0646\u0645\u0637 (\u062d\u0627\u0644\u0629- \u0634\u0627\u0647\u062f) \u0648\u0627\u0644\u062a\u064a \u0634\u0645\u0644\u062a 100 \u0645\u0631\u064a\u0636\u064d \u0645\u0634\u062e\u0635\u064a\u0646 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a \u0648\u0641\u0642 \u0645\u0639\u0627\u064a\u064a\u0631 ACR\/Eular 2010\u060c \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631\u0647\u0645 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0645\u0639\u0627\u064a\u064a\u0631 \u062a\u0636\u0645\u064a\u0646\u064d \u062f\u0642\u064a\u0642\u0629\u064d \u0623\u0647\u0645\u0647\u0627 \u0646\u0641\u064a \u0648\u062c\u0648\u062f \u0623\u0645\u0631\u0627\u0636\u064d \u062a\u0624\u062b\u0631 \u0641\u064a \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0648\u0627\u0633\u062a\u062a\u0628\u0627\u0628 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0648\u0627\u0644\u0641\u0633\u0641\u0648\u0631. \u062a\u0645\u062a \u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0651\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0645\u0639\u0628\u0631\u0627\u064b \u0639\u0646\u0647 \u0628\u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0641\u0631\u0648\u0644 \u0623\u0648 25(OH)D \u0641\u064a \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0628\u0627\u0644\u062a\u0623\u0644\u0642 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0643\u0647\u0631\u0628\u0627\u0626\u064a\u060c \u0648\u0627\u0639\u062a\u0645\u062f\u0646\u0627 \u0641\u064a \u062a\u0635\u0646\u064a\u0641 \u0623\u0641\u0631\u0627\u062f \u0645\u062c\u0645\u0648\u0639\u062a\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0634\u0651\u0648\u0627\u0647\u062f \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u062d\u0627\u0644\u0629 \u0627\u0644\u062a\u0631\u0627\u0643\u064a\u0632 \u0627\u0644\u0645\u0635\u0644\u064a\u0629 \u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0639\u0644\u0649 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(10-12).<\/p>\n<p>\u062a\u0648\u0641\u0651\u0631 \u0646\u062a\u0627\u0626\u062c \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062f\u0639\u0645\u0627\u064b \u0625\u0636\u0627\u0641\u064a\u0627\u064b \u0644\u0641\u0631\u0636\u064a\u0629 \u0627\u0644\u062f\u0648\u0631 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0644\u0644\u062a\u0639\u062f\u062f \u0627\u0644\u0634\u0651\u0643\u0644\u064aTaq-I\u00a0 (rs731236) \u0644\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0632\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D\u00a0 (VDR)\u0641\u064a \u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a(RA) \u060c \u0641\u0642\u062f \u0623\u0638\u0647\u0631 \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 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\u0633\u0627\u0626\u062f Dominant Model)\u060c \u0628\u0627\u062e\u062a\u0637\u0627\u0631 \u062a\u0637\u0651\u0648\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0640 RA \u0628\u0645\u0627 \u064a\u0642\u0627\u0631\u0628 \u0627\u0644\u0636\u0639\u0641 (OR= 2.00, P= 0.001)\u060c \u0648\u0647\u0648 \u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u0623\u062b\u064a\u0631\u064d \u062c\u064a\u0646\u064a\u0651\u064d \u0648\u0627\u0636\u062d\u064d \u0641\u064a \u0625\u0645\u0631\u0627\u0636\u064a\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u062d\u064a\u062b \u064a\u064f\u0639\u062f \u0627\u0644\u0640 Taq-I \u0645\u0646 \u0627\u0644\u062a\u0639\u062f\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0629 \u0645\u0641\u0631\u062f\u0629 \u0627\u0644\u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0627\u0644\u062a\u064a \u062a\u0642\u0639 \u0641\u064a \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0645\u0631\u0645\u0651\u0632\u0629 coding region 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\u0648\u064f\u062c\u062f \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0623\u062e\u0631\u0649 \u0623\u062c\u0631\u0627\u0647\u0627 Johnsen \u0648\u0632\u0645\u0644\u0627\u0624\u0647 (2008) \u0623\u0646 \u0627\u0644\u062a\u0639\u062f\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0629 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629\u060c \u0645\u062b\u0644 \u062a\u0644\u0643 \u0627\u0644\u0645\u0631\u0645\u0632\u0629 \u0644\u0640IL-1\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0641\u064a \u062a\u0637\u0648\u0631 \u0627\u0644\u062a\u0622\u0643\u0644\u0627\u062a \u0627\u0644\u0645\u0641\u0635\u0644\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0640RA \u0644\u0645 \u062a\u0643\u0646 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u062e\u062a\u0637\u0627\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u0631\u0636 \u0630\u0627\u062a\u0647 (26). \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u064a\u0647\u060c \u064a\u064f\u062d\u062a\u0645\u0644 \u0623\u0646\u0651 \u0627\u0644\u0623\u0644\u064a\u0644 G \u064a\u0624\u062f\u064a \u062f\u0648\u0631\u0627\u064b \u0641\u064a \u062a\u062d\u0631\u064a\u0636 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645\u0647\u062f \u0644\u0638\u0647\u0648\u0631 \u0627\u0644\u0645\u0631\u0636\u060c \u0628\u064a\u0646\u0645\u0627 \u064a\u0631\u062a\u0628\u0637 \u0627\u0644\u0646\u0645\u0637 AA \u0628\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646\u060c \u0631\u0628\u0645\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0623\u062b\u064a\u0631\u0647 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0640 VDR \u0623\u0648 \u0627\u0633\u062a\u062c\u0627\u0628\u062a\u0647 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0644\u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D\u060c \u0645\u0645\u0627 \u064a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062a\u062b\u0628\u064a\u0637\u064a \u0644\u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0639\u0644\u0649 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0645\u062b\u0644 TNF-\u03b1 \u0648IL-17\u060c \u0648IL-2 \u0627\u0644\u062a\u064a \u062a\u0646\u062a\u062c\u0647\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 T-cells\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062d\u0641\u064a\u0632 \u0631\u062f\u0648\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0651\u0629 \u0627\u0644\u0630\u0627\u062a\u064a\u0651\u0629 \u0648\u0632\u064a\u0627\u062f\u0629 \u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636 (27).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2181 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/6-3-300x278.png\" alt=\"\" width=\"413\" height=\"383\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/6-3-300x278.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/6-3.png 681w\" sizes=\"auto, (max-width: 413px) 100vw, 413px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2182 aligncenter\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/7-2-300x121.png\" alt=\"\" width=\"414\" height=\"167\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/7-2-300x121.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2026\/02\/7-2.png 672w\" sizes=\"auto, (max-width: 414px) 100vw, 414px\" \/><\/p>\n<p><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><\/p>\n<p>\u062a\u062f\u0639\u0645 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u0631\u0636\u064a\u0651\u0629 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629\u064d \u0630\u0627\u062a\u0650 \u062f\u0644\u0627\u0644\u0629 \u064d\u0625\u062d\u0635\u0627\u0626\u064a\u0629\u064d \u0628\u064a\u0646 \u0627\u0644\u062a\u063a\u0627\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a Taq-I (rs731236) \u0641\u064a \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0631\u0645\u0651\u0632 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D \u0648\u0627\u062e\u062a\u0637\u0627\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0631\u062a\u0628\u0627\u0637\u0647 \u0628\u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u0643\u0645\u0627 \u062a\u064f\u0639\u0632\u0632 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0639\u062a\u0628\u0627\u0631 \u0647\u0630\u0627 \u0627\u0644\u062a\u063a\u0627\u064a\u0631 \u0648\u0627\u0635\u0645\u0627\u064b \u062c\u064a\u0646\u064a\u0627\u064b \u0645\u0641\u064a\u062f\u0627\u064b \u0641\u064a \u0627\u0644\u062a\u0646\u0628\u0624 \u0628\u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0648\u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0633\u0647\u0645 \u0641\u064a \u062a\u0637\u0648\u064a\u0631 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0644\u0644\u0648\u0642\u0627\u064a\u0629 \u0627\u0644\u0634\u062e\u0635\u064a\u0629 \u0648\u0627\u0644\u062a\u062f\u0628\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0627\u0644\u0645\u0628\u0643\u0631.<\/p>\n<p>\u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u062a\u064f\u0648\u0635\u0649 \u0628\u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a\u064d \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u064d\u0639\u0644\u0649 \u0639\u064a\u0646\u0627\u062a \u0623\u0643\u0628\u0631 \u0648\u0645\u0646 \u0623\u0639\u0631\u0627\u0642\u064d \u0623\u0648 \u0625\u062b\u0646\u064a\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629\u064d\u060c \u062a\u062a\u0636\u0645\u0651\u0646 \u062a\u0639\u062f\u062f\u0627\u062a \u0634\u0643\u0644\u064a\u0651\u0629 \u0623\u062e\u0631\u0649 \u0641\u064a \u062c\u064a\u0646 VDR \u0648\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0628\u064a\u0626\u064a\u0629 \u0648\u0627\u0644\u063a\u0630\u0627\u0626\u064a\u0629\u060c \u0648\u0630\u0644\u0643 \u0644\u062a\u0639\u0645\u064a\u0642 \u0627\u0644\u0641\u0647\u0645 \u062d\u0648\u0644 \u0627\u0644\u062f\u0648\u0631 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0644\u0647\u0630\u0647 \u0627\u0644\u062a\u063a\u0627\u064a\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0644\u0640 RA \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0634\u0651\u062e\u0635\u0627\u0646\u064a.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0627\u062e\u062a\u0635\u0627\u0631\u0627\u062a <\/strong><strong>List of abbreviations<\/strong><\/p>\n<table style=\"width: 61.9031%;\">\n<tbody>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">ACR<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">American College of Rheumatology<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u0644\u0643\u0644\u064a\u0651\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0651\u0629 \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a\u0651\u0629<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">BMI<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Body Mass Index<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">CRP<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">C-Reactive Protein<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u062a\u0641\u0627\u0639\u0644 C<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">DAS28-CRP<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Disease Activity Score in 28 Joints with C-Reactive Protein Level<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u062d\u0631\u0632 \u0641\u0639\u0627\u0644\u064a\u0651\u0629 \u0627\u0644\u0645\u0631\u0636 \u0641\u064a 28 \u0645\u0641\u0635\u0644 \u0645\u0639 \u0642\u064a\u0645\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u062a\u0641\u0627\u0639\u0644 C<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">DNA<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Deoxyribonucleic Acid<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a \u0645\u0646\u0642\u0648\u0635 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">EDTA<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Ethylenediamine Tetraacetic Acid<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u064a\u062a\u064a\u0644\u0646 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0623\u0645\u064a\u0646 \u0631\u0628\u0627\u0639\u064a \u0627\u0644\u062e\u0644\u0627\u062a<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">EULAR<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">European Alliance of Association for Rheumatology<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u0644\u062a\u062d\u0627\u0644\u0641 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a \u0644\u0631\u0627\u0628\u0637\u0629 \u0637\u0628 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a\u0629<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">IU<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">International Unit<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0648\u062d\u062f\u0629 \u062f\u0648\u0644\u064a\u0629<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">PCR<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Polymerase Chain Reaction<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0633\u0644\u0633\u0644\u064a \u0644\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">ORs<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Ratios Odds<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0646\u0633\u0628 \u0627\u0644\u0623\u0631\u062c\u062d\u064a\u0629<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">RA<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Rheumatoid Arthritis<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a \u0623\u0648 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0631\u0648\u0645\u0627\u062a\u0648\u064a\u062f\u064a<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">SNPs<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Single Nucleotide Polymorphisms<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0627\u0644\u062a\u0639\u062f\u062f\u0627\u062a \u0627\u0644\u0634\u0643\u0644\u064a\u0629 \u0645\u0641\u0631\u062f\u0629 \u0627\u0644\u0646\u0643\u0644\u064a\u0648\u062a\u064a\u062f<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">VDR<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">Vitamin D Receptor<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646 D<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 26.8669%; text-align: center;\" width=\"60\">(OH)VD3 25<\/td>\n<td style=\"width: 38.4199%; text-align: center;\" width=\"126\">25 hydroxy Vitamin D3<\/td>\n<td style=\"width: 104.085%; text-align: center;\" width=\"125\">25 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u0641\u064a\u062a\u0627\u0645\u064a\u0646 D3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 <\/strong><strong>Ethics approval and consent to participate<\/strong><\/p>\n<p>\u062a\u062a\u0648\u0627\u0641\u0642 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0639 \u0625\u0639\u0644\u0627\u0646 \u0647\u0644\u0646\u0633\u0643\u064a \u0648\u062a\u0645\u0651 \u0625\u062c\u0631\u0627\u0624\u0647\u0627 \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0627\u0644\u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642 \u0631\u0642\u0645<\/p>\n<p>MD-210125-21-H23<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u062a\u0636\u0627\u0631\u0628 \u0627\u0644\u0645\u0635\u0627\u0644\u062d <\/strong><strong>Conflict of interests<\/strong><\/p>\n<p>\u064a\u064f\u0642\u0631\u0651 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u0628\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0645\u0635\u0627\u0644\u062d \u0645\u064f\u062a\u0636\u0627\u0631\u0628\u0629.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u062a\u0645\u0648\u064a\u0644 <\/strong><strong>Funding<\/strong><\/p>\n<p>\u0645\u064f\u0648\u0651\u0650\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u0642\u0628\u0644 \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0645\u0633\u0627\u0647\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 <\/strong><strong>Author\u2019s contributions<\/strong><\/p>\n<p>\u0642\u0627\u0645\u062a \u0632\u064a\u0646\u0628 \u0633\u0639\u064a\u062f \u0634\u062d\u0627\u062f\u0629 \u0628\u062a\u062c\u0646\u064a\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0634\u0648\u0627\u0647\u062f\u060c \u0648\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0642\u0627\u0628\u0644\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0627\u0633\u062a\u064a\u0641\u0627\u0621 \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0636\u0645\u064a\u0646 \u0648\u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f\u060c \u0643\u0645\u0627 \u0633\u0627\u0647\u0645\u062a \u0641\u064a \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0648\u0627\u0644\u062a\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0648\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0642\u0627\u064a\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629\u060c \u0648\u0634\u0627\u0631\u0643\u062a \u0641\u064a \u0625\u0639\u062f\u0627\u062f \u0627\u0644\u0645\u0633\u0648\u062f\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0644\u0644\u0645\u062e\u0637\u0648\u0637. \u0642\u0627\u0645\u062a \u0644\u0645\u0649 \u0639\u0644\u064a \u064a\u0648\u0633\u0641 \u0628\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0648\u0636\u0639 \u0625\u0637\u0627\u0631\u0647\u0627 \u0627\u0644\u0645\u0641\u0627\u0647\u064a\u0645\u064a\u060c \u0648\u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0639\u0644\u0649 \u062a\u0646\u0641\u064a\u0630\u0647\u0627 \u0648\u0645\u062a\u0627\u0628\u0639\u0629 \u0633\u064a\u0631 \u0627\u0644\u0639\u0645\u0644\u060c \u0643\u0645\u0627 \u0634\u0627\u0631\u0643\u062a \u0641\u064a \u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0625\u0639\u062f\u0627\u062f \u0627\u0644\u0645\u0633\u0648\u062f\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0644\u0644\u0645\u062e\u0637\u0648\u0637 \u0648\u062a\u0648\u0644\u0651\u062a \u0645\u0631\u0627\u062c\u0639\u062a\u0647 \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0628\u0635\u064a\u063a\u062a\u0647 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629. \u0634\u0627\u0631\u0643\u062a \u0645\u064a\u0633\u0648\u0646 \u0623\u062d\u0645\u062f \u0642\u062f\u0633\u064a \u0641\u064a \u0627\u0644\u0625\u0634\u0631\u0627\u0641 \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a \u0648\u0627\u0644\u0639\u0644\u0645\u064a \u0639\u0644\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0645\u0631\u0627\u062c\u0639\u0629 \u0645\u062d\u062a\u0648\u0627\u0647\u0627. \u062a\u0648\u0644\u0651\u0649 \u0625\u0628\u0631\u0627\u0647\u064a\u0645 \u0648\u0644\u064a\u062f \u062d\u0646\u0641\u064a \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0648\u062a\u0641\u0633\u064a\u0631 \u0646\u062a\u0627\u0626\u062c\u0647\u0627. \u0633\u0627\u0647\u0645\u062a \u0631\u0647\u0627\u0645 \u0633\u0645\u064a\u0631 \u0623\u0646\u0637\u0627\u0643\u064a \u0641\u064a \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0648\u0627\u0644\u062a\u0646\u0645\u064a\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0648\u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0647. \u0627\u0637\u0651\u0644\u0639 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0646\u0633\u062e\u0629 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u062e\u0637\u0648\u0637 \u0648\u0648\u0627\u0641\u0642\u0648\u0627 \u0639\u0644\u064a\u0647\u0627.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u064a\u064f\u0639\u062f\u0651 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u062b\u064a\u0627\u0646\u064a Rheumatoid arthritis (RA) \u0645\u0631\u0636\u0627\u064b \u0645\u0646\u0627\u0639\u064a\u0627\u064b \u0630\u0627\u062a\u064a\u0627\u064b \u0634\u0627\u0626\u0639\u0627\u064b \u0648\u0645\u0632\u0645\u0646\u0627\u064b\u060c \u064a\u0635\u064a\u0628 \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0632\u0644\u064a\u0644\u064a \u0641\u064a \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0622\u0643\u0644&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=2175\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":2183,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-2175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-158","volume-9","year-159"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2175"}],"version-history":[{"count":4,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2175\/revisions"}],"predecessor-version":[{"id":2218,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/2175\/revisions\/2218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/2183"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}