{"id":240,"date":"2022-01-01T11:36:32","date_gmt":"2022-01-01T11:36:32","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=240"},"modified":"2024-07-21T17:18:31","modified_gmt":"2024-07-21T17:18:31","slug":"%d8%aa%d8%ad%d8%b1%d9%8a-%d8%a8%d9%84%d9%88%d8%b1%d8%a9-%d8%aa%d8%b4%d8%a7%d8%b1%d9%83%d9%8a%d8%a9-%d9%84%d9%84%d9%81%d9%84%d9%88%d8%b1%d8%a8%d9%8a%d8%a8%d8%b1%d9%88%d9%81%d9%86-%d9%85%d8%b9-%d8%a7","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=240","title":{"rendered":"\u062a\u062d\u0631\u064a \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0639 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u062a\u0628\u062e\u064a\u0631 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\u0644\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0644\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u0644\u0627 \u064a\u0648\u062c\u062f \u0645\u0646\u0647\u062c \u062d\u0633\u0627\u0628\u064a \u0645\u0646\u0638\u0645 \u0648\u062f\u0642\u064a\u0642 \u064a\u0645\u0643\u0646 \u0645\u0646 \u062e\u0644\u0627\u0644\u0647 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u060c \u0644\u0642\u062f \u0642\u064f\u062f\u0651\u0645 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0646\u0627\u0647\u062c \u0627\u0644\u0646\u0638\u0631\u064a\u0629 \u0623\u0648 \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0648\u0637\u0631\u0642 \u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0645\u0646 \u0623\u062c\u0644 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0643\u0648\u0646 \u0644\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0633\u0628 <sup>4<\/sup> \u0648\u0645\u0646\u0647\u0627: \u0627\u0644\u0645\u064a\u0644 \u0644\u062a\u0634\u0643\u064a\u0644 \u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0648\u0630\u0644\u0643 \u0645\u0639 \u0627\u0644\u0627\u0633\u062a\u0639\u0627\u0646\u0629 \u0628\u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0647\u064a\u0643\u0644 \u0643\u0627\u0645\u0628\u0631\u064a\u062f\u062c Cambridge Structural Database\u00a0 (CSD) \u0648\u0637\u0631\u064a\u0642\u0629 \u0627\u0635\u0637\u0646\u0627\u0639 \u0627\u0644\u0628\u0646\u0649 \u0641\u0648\u0642 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 suprmolecular synthonic approach\u00a0 \u0648\u0645\u0639\u0627\u064a\u064a\u0631 \u0647\u0627\u0646\u0633\u0646 \u0644\u0644\u0630\u0648\u0628\u0627\u0646\u064a\u0629 Hansen solubility parameters \u0648\u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u0640 pKa.<sup>5<\/sup> \u00a0\u00a0\u0644\u0642\u062f \u0623\u0638\u0647\u0631 \u0627\u0644\u0628\u062d\u062b \u0641\u064a \u0628\u0646\u064a\u0629 \u0648\u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0632\u064a\u0627\u062f\u0629 \u0647\u0627\u0626\u0644\u0629 \u0641\u064a \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0645\u0627\u0636\u064a\u060c \u0648\u0647\u0648 \u0648\u0627\u0636\u062d \u0641\u064a \u0639\u062f\u062f \u0647\u064a\u0627\u0643\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u0648\u062f\u0639\u0629 \u0641\u064a \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0643\u0627\u0645\u0628\u0631\u064a\u062f\u062c \u0627\u0644\u0647\u064a\u0643\u0644\u064a\u0629 <sup>6<\/sup> \u0648\u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0628\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0627\u062e\u062a\u0631\u0627\u0639 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0625\u0644\u0627 \u0623\u0646\u0651\u0647\u060c \u0645\u0646 \u0627\u0644\u0645\u062f\u0647\u0634 \u0623\u0646 \u0637\u0631\u0642 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0645\u0627\u062a\u0632\u0627\u0644\u060c \u062d\u062a\u0649 \u0648\u0642\u062a \u0642\u0631\u064a\u0628 \u0646\u0633\u0628\u064a\u064b\u0627\u060c \u063a\u064a\u0631 \u0645\u062d\u062f\u062f\u0629 \u0625\u0644\u0649 \u062d\u062f \u0643\u0628\u064a\u0631\u060c \u0648\u064f\u062c\u0651\u0647 \u0627\u0647\u062a\u0645\u0627\u0645 \u0628\u062d\u062b\u064a \u0645\u062d\u062f\u0648\u062f \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062a\u062d\u062f\u064a\u062f \u0644\u0625\u0639\u062f\u0627\u062f \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629\u060c \u0648\u064a\u062a\u0644\u0642\u0649 \u0647\u0630\u0627 \u0627\u0644\u0645\u0648\u0636\u0648\u0639 \u0627\u0644\u0642\u0644\u064a\u0644 \u0645\u0646 \u0627\u0644\u062a\u0641\u0627\u0635\u064a\u0644 \u0641\u064a \u063a\u0627\u0644\u0628\u064a\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629.<sup>3<\/sup> \u062a\u0645 \u062a\u0648\u062b\u064a\u0642 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0637\u0631\u0642 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0646\u0627\u062c\u062d\u0629: \u062a\u0628\u062e\u0631 \u0627\u0644\u0645\u0630\u064a\u0628\u0627\u062a solvent evaporation \u0648\u0637\u062d\u0646 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0635\u0644\u0628\u0629 solid state grinding\u00a0 \u0648\u062a\u0628\u0644\u0648\u0631 \u0627\u0644\u0645\u062d\u0627\u0644\u064a\u0644 solution crystallization \u0648\u062a\u062d\u0648\u064a\u0644 \u0627\u0644\u0631\u0648\u0628\u0629 slurry conversion \u0648\u0627\u0644\u062a\u0628\u0644\u0648\u0631 \u0628\u0627\u0644\u0627\u0646\u0635\u0647\u0627\u0631 melt crystallization \u0648\u0627\u0644\u0627\u0646\u062a\u0632\u0627\u0639 \u0645\u0646 \u0627\u0644\u0645\u0635\u0647\u0648\u0631 \u0627\u0644\u0633\u0627\u062e\u0646 hot melt extrusion\u00a0 \u0648\u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0628\u0627\u0644\u0625\u0631\u0630\u0627\u0630 spray crystallization \u00a0<sup>3<\/sup> \u0648\u0644\u0643\u0646 \u0647\u0646\u0627\u0643 \u0627\u0644\u0642\u0644\u064a\u0644 \u0645\u0646 \u0627\u0644\u0627\u062a\u0633\u0627\u0642 \u0641\u064a \u062a\u0637\u0628\u064a\u0642 \u0623\u0633\u0627\u0644\u064a\u0628 \u0627\u0644\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0623\u0648 \u062d\u062a\u0649 \u0641\u064a \u0627\u0644\u0645\u0635\u0637\u0644\u062d\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0648\u0635\u0641 \u0646\u0641\u0633 \u0627\u0644\u0634\u064a\u0621<sup>6<\/sup>. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0638\u0647\u0631\u062a \u0639\u062f\u0629 \u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0627\u0635\u0637\u0646\u0627\u0639 \u0628\u0644\u0648\u0631\u0627\u062a \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u064a\u062a\u0623\u062b\u0631 \u0628\u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062a\u0623\u062b\u0631 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0628\u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u0645\u0630\u064a\u0628\u0627\u062a \u0648\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u062a\u0641\u0627\u0639\u0644\u0629\u060c \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644: \u0648\u062c\u0648\u062f \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0648\u0638\u064a\u0641\u064a\u0629 functional groups \u0648\u0642\u0627\u0628\u0644\u064a\u0629 \u0630\u0648\u0628\u0627\u0646 solubility \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u062a\u0641\u0627\u0639\u0644\u0629 \u0641\u064a \u0627\u0644\u0645\u0630\u064a\u0628 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0638\u0631\u0648\u0641 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0645\u062b\u0644 \u0646\u0633\u0628\u0629 \u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0627\u0644\u0645\u062a\u0643\u0627\u0641\u0626\u0629 \u0628\u064a\u0646 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0643\u0648\u0646 \u0644\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0648\u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 API\u00a0 stoichiometric ratio of the coformer and API\u060c \u0648\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629\u060c \u0648\u0627\u0644\u062a\u062d\u0631\u064a\u0643 stirring\u060c \u0648\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0645\u0648\u0636\u0629 pH\u060c \u0648\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0627\u0646\u064a \u0627\u0644\u0632\u062c\u0627\u062c\u064a type of glassware\u060c\u00a0 \u0648\u0643\u0644 \u0645\u0627 \u0633\u0628\u0642 \u0644\u064a\u0633 \u0633\u0648\u0649 \u0639\u062f\u062f \u0642\u0644\u064a\u0644 \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0645\u0627\u062a \u0627\u0644\u0645\u0624\u062b\u0631\u0629 effective parameters.<sup>7<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u00a0\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Materials and Methods<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f <\/strong><strong>Materials<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062c\u0631\u0649 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649:\u00a0\u00a0 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646\u00a0 \u0643\u0647\u062f\u064a\u0629\u00a0 \u0645\u0646 \u0634\u0631\u0643\u0629 \u0627\u0644\u0641\u0627\u0631\u0633 \u0644\u0644\u0635\u0646\u0627\u0639\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629\u060c\u00a0 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0645\u0646 \u0634\u0631\u0643\u0629 MERCK \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064a\u0629\u060c \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0645\u0646\u00a0 \u0634\u0631\u0643\u0629\u00a0 MERCK \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064a\u0629\u060c \u0627\u0644\u0643\u062d\u0648\u0644 \u0627\u0644\u0625\u064a\u062a\u064a\u0644\u064a \u0648\u0627\u0644\u0645\u064a\u062a\u064a\u0644\u064a \u0645\u0646 \u0634\u0631\u0643\u0629 MERCK \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064a\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0623\u062c\u0647\u0632\u0629 <\/strong><strong>Instrumentation<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629: \u0645\u064a\u0632\u0627\u0646 \u062d\u0633\u0627\u0633 \u0648\u0645\u0628\u062e\u0631 \u062f\u0648\u0627\u0631 \u0648\u0641\u0631\u0646 \u062a\u062c\u0641\u064a\u0641\u060c \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a\u00a0 DSC \u0646\u0645\u0648\u0630\u062c DSC131 \u0641\u0631\u0646\u0633\u0627\u060c \u0648\u062c\u0647\u0627\u0632 \u0645\u0642\u064a\u0627\u0633 \u0637\u064a\u0641 \u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 Infra-Red \u0645\u0646 \u0634\u0631\u0643\u0629 Bruker\u060c \u062c\u0647\u0627\u0632 \u0641\u062d\u0635 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u00a0Pharmatest \u0646\u0645\u0648\u0630\u062c \u00a0PT-DT7 \u060c \u0648\u062c\u0647\u0627\u0632 \u0645\u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0636\u0648\u0626\u064a \u0646\u0645\u0648\u0630\u062c T80+\u060c \u062c\u0647\u0627\u0632 HPLC \u0645\u0646 \u0634\u0631\u0643\u0629 Shimadzu.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><strong>Methods<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u062a \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u062d\u0636\u064a\u0631 \u0644\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u062a\u0628\u062e\u064a\u0631 \u0627\u0644\u0645\u0630\u064a\u0628 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629.<\/span><\/p>\n<ol style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u0628\u0637\u064a\u0626\u0629:<\/strong><\/span><\/li>\n<\/ol>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0628\u0643 :<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0628\u0637\u0631\u064a\u0642\u0629\u00a0 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0628\u0646\u0633\u0628\u0629 \u0645\u0648\u0644\u064a\u0629 (1:1):\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064a\u062b \u062d\u064f\u0644\u0651 \u0645\u0642\u062f\u0627\u0631 8.18 \u0645\u064a\u0644\u064a \u0645\u0648\u0644 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0641\u064a \u0643\u0645\u064a\u0629 \u0643\u0627\u0641\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u064a\u062a\u0627\u0646\u0648\u0644 \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0625\u0630\u0627\u0628\u0629 \u0643\u0627\u0645\u0644 \u0627\u0644\u0643\u0645\u064a\u0629 \u062b\u0645 \u062a\u0645 \u062a\u0631\u0634\u064a\u062d \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0644\u0649 \u0645\u0631\u0627\u0634\u062d \u0645\u064a\u0644\u064a \u0628\u0648\u0631 0.45 \u0645\u064a\u0643\u0631\u0648\u0646 \u0648\u062a\u0631\u0643 \u0647\u0630\u0627 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0641\u062a\u0631\u0629 \u0632\u0645\u0646\u064a\u0629 \u062a\u0642\u0627\u0631\u0628 120 \u0633\u0627\u0639\u0629\u00a0 \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 25\u1d52 \u0644\u062a\u0628\u062e\u064a\u0631 \u0643\u0627\u0645\u0644 \u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0630\u064a\u0628 \u0648\u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062c\u0627\u0641\u0629. \u062b\u0645 \u062a\u0645 \u0646\u062e\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0644\u0649 \u0645\u0646\u062e\u0644 \u0630\u0648 \u0623\u0628\u0639\u0627\u062f (500 \u0645\u064a\u0643\u0631\u0648\u0646) \u062b\u0645 \u062d\u064f\u0641\u0638\u062a \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0628\u0639\u0628\u0648\u0627\u062a \u0645\u062d\u0643\u0645\u0629 \u0627\u0644\u0625\u063a\u0644\u0627\u0642 \u062d\u062a\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u062a\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0644\u0627\u062d\u0642\u0629.<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0645\u0639 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0628\u0646\u0633\u0628\u0629 \u0645\u0648\u0644\u064a\u0629 (1:1):<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064a\u062b \u062a\u0645 \u062d\u0644 \u0645\u0642\u062f\u0627\u0631 8.18 \u0645\u064a\u0644\u064a \u0645\u0648\u0644 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0641\u064a \u0643\u0645\u064a\u0629 \u0643\u0627\u0641\u064a\u0629 \u0645\u0646 \u0627\u0644\u0625\u064a\u062a\u0627\u0646\u0648\u0644 \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0625\u0630\u0627\u0628\u0629 \u0643\u0627\u0645\u0644 \u0627\u0644\u0643\u0645\u064a\u0629 \u062b\u0645 \u062b\u0645 \u0631\u064f\u0634\u0651\u062d \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0644\u0649 \u0645\u0631\u0627\u0634\u062d \u0645\u064a\u0644\u064a \u0628\u0648\u0631 0.45 \u0645\u064a\u0643\u0631\u0648\u0646 \u0648\u062a\u0631\u0643 \u0647\u0630\u0627 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0641\u062a\u0631\u0629 \u0632\u0645\u0646\u064a\u0629\u00a0 \u062a\u0642\u0627\u0631\u0628 72 \u0633\u0627\u0639\u0629 \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 25<sup>\u1d52<\/sup> \u0645 \u0644\u062a\u0628\u062e\u064a\u0631 \u0643\u0627\u0645\u0644 \u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0630\u064a\u0628 \u0648\u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062c\u0627\u0641\u0629. \u062b\u0645 \u062a\u0645 \u0646\u062e\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0644\u0649 \u0645\u0646\u062e\u0644 \u0630\u0648 \u0623\u0628\u0639\u0627\u062f (500 \u0645\u064a\u0643\u0631\u0648\u0646) \u062b\u0645 \u062d\u064f\u0641\u0638\u062a \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0628\u0639\u0628\u0648\u0627\u062a \u0645\u062d\u0643\u0645\u0629 \u0627\u0644\u0625\u063a\u0644\u0627\u0642 \u062d\u062a\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u062a\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0644\u0627\u062d\u0642\u0629.<\/span><\/p>\n<ol style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629:<\/strong><\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0648\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0628\u062e\u0631 \u0627\u0644\u062f\u0648\u0627\u0631:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064a\u062b \u0648\u064f\u0632\u0646\u062a \u0643\u0645\u064a\u0627\u062a \u0645\u0643\u0627\u0641\u0626\u0629 \u0628\u0646\u0633\u0628\u0629 \u0645\u0648\u0644\u064a\u0629 \u062b\u0627\u0628\u062a\u0629 (1 : 1) \u0645\u0646 \u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0639 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0643\u0644 \u0645\u0646\u0647\u0627 \u0639\u0644\u0649 \u062d\u062f\u0649 \u062b\u0645 \u062d\u0644\u062a \u0641\u064a \u0623\u0642\u0644 \u0643\u0645\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u062d\u0644 \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u062d\u064a\u062b \u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0625\u064a\u062a\u0627\u0646\u0648\u0644 \u0645\u0639 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u0627\u0644\u0645\u064a\u062a\u0627\u0646\u0648\u0644 \u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648\u0628\u0627\u0644\u0627\u0633\u062a\u0639\u0627\u0646\u0629 \u0628\u0627\u0644\u0623\u0645\u0648\u0627\u062c \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0641\u062a\u0631\u0629 \u0632\u0645\u0646\u064a\u0629 \u0644\u0627 \u062a\u0632\u064a\u062f \u0639\u0646 60 \u062b\u0627\u0646\u064a\u0629 \u0628\u0647\u062f\u0641 \u062a\u0633\u0631\u064a\u0639 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0631\u064f\u0634\u0651\u062d \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0644\u0649 \u0645\u0631\u0627\u0634\u062d 0.45 \u0645\u064a\u0643\u0631\u0648\u0646 \u0648\u062a\u0645 \u0648\u0636\u0639 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0644\u0649 \u0627\u0644\u0645\u0628\u062e\u0631 \u0627\u0644\u062f\u0648\u0627\u0631 \u062d\u062a\u0649 \u0627\u0646\u062a\u0647\u0627\u0621 \u0643\u0627\u0645\u0644 \u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u062d\u0644. \u0628\u0639\u062f \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u062c\u064f\u0641\u0641\u062a \u0641\u064a \u0645\u062d\u0645 \u0644\u0645\u062f\u0629 \u0633\u0627\u0639\u062a\u064a\u0646 \u0648\u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 30<sup>\u1d52<\/sup>\u0645\u00a0 \u062b\u0645 \u0646\u064f\u062e\u0644\u062a \u0639\u0644\u0649 \u0645\u0646\u062e\u0644\u00a0 \u0628\u0623\u0628\u0639\u0627\u062f (500 \u0645\u064a\u0643\u0631\u0648\u0646) \u0648\u0648\u064f\u0636\u0639\u062a \u0641\u064a \u0639\u0628\u0648\u0627\u062a \u0645\u062d\u0643\u0645\u0629 \u0627\u0644\u0625\u063a\u0644\u0627\u0642 \u062d\u062a\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u062a\u062d\u0627\u0644\u064a\u0644 \u0627\u0644\u0644\u0627\u062d\u0642\u0629<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u062e\u062a\u0628\u0627\u0631 \u062a\u062c\u0627\u0646\u0633 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0644\u0644\u0645\u0633\u062d\u0648\u0642\u00a0 (<\/strong><strong>Uniformity of recrystallized powder<\/strong><strong>):<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0632\u0646\u062a \u0643\u0645\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0633\u062d\u0648\u0642 \u0627\u0644\u0645\u0639\u0627\u062f \u0628\u0644\u0648\u0631\u062a\u0647 \u0645\u0643\u0627\u0641\u0626\u0629 \u0644\u0640 (10 \u0645\u063a) \u062f\u0648\u0627\u0621 \u0646\u0638\u0631\u064a\u0627\u064b \u0648\u062a\u0645\u062f\u064a\u062f\u0647\u0627 \u0628\u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0645\u062a\u062d\u0631\u0643 \u0648\u0635\u0648\u0644\u0627\u064b \u0625\u0644\u0649 \u062a\u0631\u0643\u064a\u0632 \u064a\u0642\u0627\u0631\u0628 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0639\u064a\u0627\u0631\u064a \u0648\u0645\u0646 \u062b\u0645 \u062a\u0645 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u062d\u0644\u0648\u0644 \u0639\u0644\u0649 \u062c\u0647\u0627\u0632\u00a0 HPLC \u0648\u0641\u0642 \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629 \u00a0USP 41 NF 36 \u0648\u062d\u0633\u0627\u0628 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0648\u0643\u0645\u064a\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629\u00a0 \u0627\u0644\u0639\u0645\u0644\u064a\u0629. \u062a\u0645 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0639\u0644\u0649 \u062b\u0644\u0627\u062b \u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0627\u0644\u0645\u0633\u062d\u0648\u0642 \u0627\u0644\u0645\u0641\u062d\u0648\u0635 \u0630\u0627\u062a\u0647 \u0645\u0646 \u0639\u062f\u0629 \u0623\u0645\u0627\u0643\u0646 \u0645\u0646 \u0627\u0644\u0639\u0628\u0648\u0629 (\u0639\u0644\u0628\u0629 \u0628\u062a\u0631\u064a) \u062b\u0645 \u062a\u0645 \u062d\u0633\u0627\u0628 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0646\u0633\u0628\u064a \u0648\u0627\u0644\u0648\u0633\u064a\u0637 (MEDIAN).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621(<\/strong><strong>FTIR<\/strong> <strong>Spectroscopy<\/strong><strong>):<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u0645\u0633\u062d \u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0643\u0644 \u0645\u0646 \u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0623\u0633\u064a\u062f \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f\u060c \u0643\u0645\u0627 \u0623\u062c\u0631\u064a \u0645\u0633\u062d \u0637\u064a\u0641\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0639 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u0633\u0627\u0628\u0642\u062a\u064a\u0646 \u0628\u0646\u0633\u0628\u0629 (1:1 \u0645\u0648\u0644) \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u062a\u064a\u0646 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629\u060c \u062d\u064a\u062b\u00a0 \u0645\u064f\u0632\u062c\u062a \u0643\u0644 \u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0645\u0639 \u0643\u0645\u064a\u0629 \u0645\u0646 \u062d\u0628\u064a\u0628\u0627\u062a \u0628\u0631\u0648\u0645 \u0627\u0644\u0628\u0648\u062a\u0627\u0633\u064a\u0648\u0645 \u0627\u0644\u062c\u0627\u0641\u0629 \u062a\u0645\u0627\u0645\u0627\u064b \u062b\u0645 \u0636\u064f\u063a\u0637\u062a \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0639\u0644\u0649 \u0634\u0643\u0644 \u0642\u0631\u0635 \u0634\u0641\u0627\u0641 \u0648\u062a\u0645 \u0648\u0636\u0639\u0647 \u0636\u0645\u0646 \u0627\u0644\u062c\u0647\u0627\u0632 \u062d\u064a\u062b \u062a\u0645 \u062a\u0633\u062c\u064a\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u0637\u064a\u0627\u0641\u00a0 \u0636\u0645\u0646 \u0627\u0644\u0645\u062c\u0627\u0644 (400 \u2013 4000) \u0633\u0645 <sup>-1<\/sup>. <sup>8<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0627\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a <\/strong><strong>Differential Scanning Calorimetry<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u064f\u0642\u0644\u062a \u0639\u064a\u0646\u0629 (4-5) \u0645\u063a \u0645\u0646 \u0643\u0644 \u0639\u064a\u0646\u0629 \u0625\u0644\u0649 \u0628\u0648\u062a\u0642\u0629 \u062e\u0627\u0635\u0629 \u0645\u0635\u0646\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645 \u0648\u062a\u0645 \u0625\u062d\u0643\u0627\u0645 \u0625\u063a\u0644\u0627\u0642\u0647\u0627 \u062c\u064a\u062f\u0627\u064b \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0643\u0628\u0633 \u062e\u0627\u0635 \u0648\u0623\u064f\u062c\u0631\u064a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0648\u062a\u0642\u0629 \u0641\u0627\u0631\u063a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0644\u0645\u0646\u064a\u0648\u0645 \u0643\u0634\u0627\u0647\u062f \u0648\u0630\u0644\u0643 \u0628\u062a\u0639\u0631\u064a\u0636 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0625\u0644\u0649 \u062d\u0631\u0627\u0631\u0629 \u0645\u062a\u0632\u0627\u064a\u062f\u0629 \u0636\u0645\u0646 \u0645\u062c\u0627\u0644 \u0645\u0633\u062d \u064a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 (25-200 )\u1d52\u0645\u060c \u0648\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0641\u062d\u0635 \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0631\u0648\u0641\u0646 \u0645\u0639 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0627\u0644\u0633\u0627\u0628\u0642\u062a\u064a\u0646 \u0628\u0646\u0633\u0628\u0629 (1:1 \u0645\u0648\u0644) \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u062a\u064a\u0646 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0641\u062d\u0635 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u00a0 \u0623\u0648 \u062f\u0631\u0627\u0633\u0629<\/strong> <strong>\u062a\u062d\u0631\u0631<\/strong> <strong>\u0627\u0644\u0645\u0627\u062f\u0629<\/strong> <strong>\u0627\u0644\u0641\u0639\u0627\u0644\u0629<\/strong> <strong>\u0641\u064a<\/strong> <strong>\u0627\u0644\u0632\u062c\u0627\u062c <\/strong><strong>In Vitro<\/strong> <strong>Dissolution Profile<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633 \u0645\u0639\u062f\u0644 \u062a\u062d\u0631\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0645\u0633\u0627\u062d\u064a\u0642\u00a0 (API+Coformer) \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0648\u0630\u0644\u0643 \u0628\u0639\u062f \u062a\u0645\u0631\u064a\u0631\u0647\u0627 \u0639\u0644\u0649 \u0645\u0646\u062e\u0644 \u0628\u0623\u0628\u0639\u0627\u062f 500 \u0645\u064a\u0643\u0631\u0648\u0646 \u0628\u0647\u062f\u0641 \u0645\u062c\u0627\u0646\u0633\u0629 \u0627\u0644\u0623\u0628\u0639\u0627\u062f \u0648\u0630\u0644\u0643 \u0628\u0648\u0632\u0646 3 \u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0643\u0644 \u0645\u0633\u062d\u0648\u0642 \u0645\u0643\u0627\u0641\u0626\u0629 \u0644\u0640 (50 \u0645\u063a) \u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0648\u0636\u0639\u0647\u0627 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062d\u064a\u062b \u0627\u0639\u062a\u0645\u062f\u062a \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629 USP 41 NF 36\u00a0 \u0645\u0639 \u062a\u0639\u062f\u064a\u0644 \u0648\u0627\u062d\u062f \u0641\u0642\u0637: \u062d\u064a\u062b \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0633\u0644\u0629 \u0627\u0644\u062f\u0648\u0627\u0631\u0629 \u0639\u0648\u0636\u0627\u064b \u0639\u0646 \u0627\u0644\u0645\u062c\u062f\u0627\u0641 \u0645\u0639 \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629 \u0639\u0644\u0649 \u0628\u0627\u0642\u064a \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629. \u062a\u0645 \u062a\u062d\u062f\u064a\u062f \u0643\u0645\u064a\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0632\u0645\u0646 \u0628\u0633\u062d\u0628 \u0639\u064a\u0646\u0627\u062a \u062d\u062c\u0645\u0647\u0627 5 \u0645\u0644 \u0639\u0646\u062f \u0641\u0648\u0627\u0635\u0644 \u0632\u0645\u0646\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 (5\u060c 10\u060c 15\u060c 20\u060c 30) \u062f\u0642\u064a\u0642\u0629 \u0648\u062a\u0631\u0634\u064a\u062d\u0647\u0627 \u0639\u0628\u0631 \u0645\u0631\u0627\u0634\u062d \u0645\u064a\u0644\u0644\u064a \u0628\u0648\u0631 \u0641\u0644\u062a\u0631 (0.45) \u0648\u062a\u0639\u0648\u064a\u0636\u0647\u0627 \u0628\u0643\u0645\u064a\u0627\u062a \u0645\u0633\u0627\u0648\u064a\u0629 \u0645\u0646 \u0648\u0633\u0637 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u060c \u062b\u0645 \u062c\u0631\u0649 \u062d\u0633\u0627\u0628\u00a0 \u0643\u0645\u064a\u0629 \u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631\u0629 \u0628\u0642\u064a\u0627\u0633 \u0627\u0645\u062a\u0635\u0627\u0635\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u0647\u0627\u0632 \u0627\u0644\u0627\u0633\u062a\u0634\u0631\u0627\u0628 \u0627\u0644\u0633\u0627\u0626\u0644 \u0639\u0627\u0644\u064a \u0627\u0644\u0623\u062f\u0627\u0621 \u0648\u0641\u0642 \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062f\u0633\u062a\u0648\u0631\u064a\u0629. \u062a\u0645 \u062f\u0631\u0627\u0633\u0629 \u062b\u0644\u0627\u062b\u0629 \u0639\u064a\u0646\u0627\u062a \u0644\u0643\u0644 \u062a\u062c\u0631\u0628\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u062e\u062a\u0628\u0627\u0631 \u062a\u062c\u0627\u0646\u0633 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0644\u0644\u0645\u0633\u062d\u0648\u0642 <\/strong><strong>Uniformity of recrystallized powder<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0627\u0648\u0644 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 (1\u060c 2) \u0646\u062a\u064a\u062c\u0629 \u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0641\u064a \u0645\u0633\u0627\u062d\u064a\u0642 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0648\u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0639\u0644\u0649 \u062d\u062f\u0629\u060c\u00a0 \u062d\u064a\u062b \u0628\u0639\u062f \u0645\u0639\u0627\u064a\u0631\u0629 \u0643\u0644 \u0639\u064a\u0646\u0629 \u0644\u0648\u062d\u062f\u0647\u0627 \u0644\u0645\u00a0 \u062a\u062a\u062c\u0627\u0648\u0632 \u0642\u064a\u0645\u0629 \u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0627\u0644\u0646\u0633\u0628\u064a 5% \u0648\u062a\u0631\u0627\u0648\u062d\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062b \u0641\u064a \u0645\u062c\u0627\u0644 \u0644\u0627 \u064a\u062a\u062c\u0627\u0648\u0632 10% \u0645\u0646 \u0642\u064a\u0645\u0629 \u0627\u0644\u0648\u0633\u064a\u0637 \u0648\u0645\u0646 \u062b\u0645\u0651 \u0643\u0627\u0646\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0633\u0627\u062d\u064a\u0642 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646.<sup>9<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-579 \" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-15-e1699107129865-300x163.png\" alt=\"\" width=\"495\" height=\"269\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-15-e1699107129865-300x163.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-15-e1699107129865-1024x555.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-15-e1699107129865-768x416.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-15-e1699107129865-1536x832.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-15-e1699107129865-2048x1109.png 2048w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621(<\/strong><strong>FTIR<\/strong> <strong>Spectroscopy<\/strong><strong>):<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u062c\u0631\u0649 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0648\u0645\u0644\u0627\u062d\u0638\u0629 \u062d\u062f\u0648\u062b \u0623\u064a \u062a\u063a\u064a\u064a\u0631\u0627\u062a \u0648\u062e\u0627\u0635\u0629 \u0639\u0646\u062f \u0627\u0644\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u0631\u0648\u0627\u0628\u0637 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0639\u0644\u0649 \u0627\u0639\u062a\u0628\u0627\u0631 \u0623\u0646 \u0627\u0644\u0631\u0627\u0628\u0637 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a \u0647\u0648 \u0627\u0644\u0642\u0648\u0629 \u0627\u0644\u062f\u0627\u0641\u0639\u0629 \u0644\u062a\u0634\u0643\u064a\u0644 \u0628\u0644\u0648\u0631\u0627\u062a \u062a\u0634\u0627\u0631\u0643\u064a\u0629. <sup>1<\/sup> \u0623\u0638\u0647\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 (\u0627\u0644\u0634\u0643\u0644 1) \u0638\u0647\u0648\u0631 \u0642\u0645\u0629 \u0639\u0631\u064a\u0636\u0629 \u062a\u0645\u062a\u062f 2500-3200 \u0633\u0645<sup>-1<\/sup> \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0627\u0645\u062a\u0637\u0627\u0637\u00a0 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644 \u0627\u0644\u062d\u0645\u0636\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0648\u0647\u0630\u0627 \u0628\u0633\u0628\u0628 \u0648\u062c\u0648\u062f \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0639\u0644\u0649 \u0634\u0643\u0644 \u062a\u062c\u0645\u0639\u0627\u062a \u062b\u0646\u0627\u0626\u064a\u0629 dimer aggregation \u060c \u0648\u0646\u0644\u0627\u062d\u0638 \u0638\u0647\u0648\u0631 \u0642\u0645\u0629 \u062d\u0627\u062f\u0629 \u0639\u0646\u062f 1700 \u0633\u0645<sup>-1<\/sup>\u00a0 \u062a\u0639\u0648\u062f \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064a\u0644 \u0627\u0644\u062d\u0645\u0636\u064a\u0629 \u0648\u0642\u0645\u0629 \u0639\u0646\u062f 1217 \u0633\u0645<sup>-1<\/sup> \u062a\u0639\u0648\u062f \u0644\u0627\u0645\u062a\u0637\u0627\u0637 \u0645\u062c\u0645\u0648\u0639\u0629 C-F.<sup>10<\/sup> \u0623\u0645\u0627 \u0641\u064a \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f\u00a0 (\u0627\u0644\u0634\u0643\u0644 1) \u0631\u0635\u062f\u062a \u0627\u0644\u062a\u063a\u064a\u064a\u0631\u0627\u062a \u0639\u0644\u0649 \u0627\u0647\u062a\u0632\u0627\u0632 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646 \u0627\u0644\u0623\u0648\u0644\u064a \u0627\u0644\u062a\u064a \u062a\u062a\u0648\u0627\u062c\u062f \u0628\u0634\u0643\u0644 \u0639\u0635\u0627\u0628\u062a\u0627\u0646 \u0648\u062a\u0645\u062a\u062f \u0645\u0646 3100-3425 \u0633\u0645 -1. <sup>11<\/sup> \u0644\u0648\u062d\u0638 \u0641\u064a \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a\u00a0 \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0628\u0646\u0633\u0628\u0629 (1:1) (\u0627\u0644\u0634\u0643\u0644 1) \u0638\u0647\u0648\u0631 \u062c\u0645\u064a\u0639 \u0627\u0644\u0642\u0645\u0645 \u062f\u0648\u0646 \u0623\u064a \u0627\u0646\u0632\u064a\u0627\u062d \u0648\u0647\u0630\u0627 \u064a\u0639\u0648\u062f \u0645\u0624\u0634\u0631 \u0644\u0639\u062f\u0645 \u062d\u062f\u0648\u062b \u062a\u063a\u064a\u064a\u0631\u0627\u062a \u062c\u0648\u0647\u0631\u064a\u0629 \u0641\u064a \u0627\u0644\u062a\u0648\u0636\u0639 \u0648\u0627\u0644\u0631\u0648\u0627\u0628\u0637 \u0628\u064a\u0646 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629. \u0623\u0638\u0647\u0631 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0628\u0646\u0633\u0628\u0629 (1:1)\u00a0 \u0628\u0644\u0648\u0631\u0629 \u0633\u0631\u064a\u0639\u0629\u00a0 (\u0627\u0644\u0634\u0643\u06441) \u062d\u062f\u0648\u062b \u062a\u063a\u064a\u064a\u0631\u0627\u062a \u0637\u0641\u064a\u0641\u0629 \u0634\u0645\u0644\u062a \u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u0634\u062f\u0629\u00a0 \u0642\u0645\u0629 \u0627\u0645\u062a\u0637\u0627\u0637 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646 \u0641\u064a \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u062a\u0633\u0627\u0639 \u0641\u064a \u0639\u0631\u0636 \u0642\u0645\u0629 \u0627\u0645\u062a\u0637\u0627\u0637 \u0645\u062c\u0645\u0648\u0639\u0629\u00a0 OH \u0641\u064a \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u0634\u062f\u0629 \u0627\u0647\u062a\u0632\u0627\u0632 \u0627\u0645\u062a\u0637\u0627\u0637\u00a0 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064a\u0644 \u0648\u0627\u0646\u0632\u064a\u0627\u062d \u0637\u0641\u064a\u0641 \u0641\u064a \u0639\u062f\u0629 \u0642\u0645\u0645 (1210 \u0648 1050\u0648 1120) \u0633\u0645<sup>-1<\/sup> \u0648\u0647\u0630\u0627 \u0628\u0633\u0628\u0628 \u0648\u062c\u0648\u062f \u0631\u0648\u0627\u0628\u0637 \u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0628\u064a\u0646 \u062c\u0632\u064a\u0626\u0627\u062a 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\u0623\u0642\u0644 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0633\u0631\u064a\u0639\u0629 \u0648\u0625\u0646\u0645\u0627 \u0627\u0642\u062a\u0635\u0631\u062a \u0627\u062a\u0633\u0627\u0639 \u0642\u0645\u0629 \u0627\u0647\u062a\u0632\u0627\u0632 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644 \u0644\u062a\u0634\u0645\u0644 2500-3450 \u0644\u062a\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0627\u0647\u062a\u0632\u0627\u0632 \u0627\u0645\u062a\u0637\u0627\u0637 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0646 \u0641\u064a \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u0627\u062a\u0633\u0627\u0639 \u0639\u0631\u0636 \u0642\u0645\u0629 \u0627\u0644\u0643\u0631\u0628\u0648\u0646\u064a\u0644 \u0644\u062a\u0645\u062a\u062f \u0645\u0646 1650-1750 \u0648\u0647\u0630\u0647\u00a0 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u0627\u0644\u0631\u0627\u0628\u0637\u0629 \u0627\u0644\u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629. \u0648\u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0628\u0646\u0633\u0628\u0629 (1:1) (\u0627\u0644\u0634\u0643\u0644\u00a0 3 \u0648 4) \u064a\u0645\u0643\u0646 \u0627\u0639\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u062e\u0637\u0637 \u0627\u0644\u0646\u0627\u062a\u062c \u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0645\u062c\u0645\u0648\u0639 \u0643\u0644 \u0645\u0646 \u0645\u062e\u0637\u0637 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0645\u0639 \u0639\u062f\u0645 \u062d\u062f\u0648\u062b \u0623\u064a \u062a\u063a\u064a\u064a\u0631\u0627\u062a \u062a\u0630\u0643\u0631.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0627\u0644\u062d\u0631\u0627\u0631\u064a <\/strong><strong>DSC<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0638\u0647\u0648\u0631 \u0642\u0645\u0629 \u0648\u062d\u064a\u062f\u0629 \u062d\u0627\u062f\u0629 \u0648\u0634\u062f\u064a\u062f\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 115.73\u00ba\u0645 \u0648\u0647\u064a \u062a\u0648\u0627\u0641\u0642 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 <sup>12<\/sup> \u0643\u0645\u0627 \u0647\u0648 \u0648\u0627\u0636\u062d \u0641\u064a \u0627\u0644\u0634\u0643\u0644 5\u060c \u0648\u064a\u0628\u064a\u0646 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f\u00a0 (\u0627\u0644\u0634\u0643\u0644\u00a0 5) \u0638\u0647\u0648\u0631 \u0642\u0645\u0629 \u0648\u062d\u064a\u062f\u0629 \u062d\u0627\u062f\u0629 \u0645\u0627\u0635\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 130.58\u00ba\u0645 \u0648\u0647\u064a \u062a\u0648\u0627\u0641\u0642 \u062f\u0631\u062c\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0647\u0630\u0647 \u0627\u0644\u0645\u0627\u062f\u0629.<sup>11<\/sup> \u0648\u064a\u0648\u0636\u062d \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0639 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0628\u0646\u0633\u0628\u0629 (1:1) \u0638\u0647\u0648\u0631 \u0642\u0645\u062a\u064a\u0646 \u0645\u0627\u0635\u062a\u064a\u0646 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0645\u062a\u0648\u0633\u0637\u062a\u064a \u0627\u0644\u0634\u062f\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 79.92\u00ba\u0645 \u0648 \u062f\u0631\u062c\u0629 96.67\u00ba\u0645 \u0648\u0638\u0647\u0648\u0631 \u0642\u0645\u0629 \u0639\u0631\u064a\u0636\u0629 \u0648\u0636\u0639\u064a\u0641\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 108.01\u00ba\u0645 \u062d\u064a\u062b \u064a\u0631\u062c\u062d \u0643\u0648\u0646 \u0627\u0644\u0642\u0645\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629 \u0648 \u0627\u0644\u0642\u0645\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0633\u0637\u0629\u00a0 \u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0632\u064a\u062c \u0623\u0635\u0647\u0631\u064a (eutectic mixture) \u0628\u064a\u0646\u0645\u0627 \u0645\u0639 \u0643\u0648\u0646 \u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0642\u0645\u062a\u064a\u0646 \u0645\u062e\u062a\u0644\u0641\u062a\u064a\u0646 \u0639\u0646 \u0642\u0645\u0645 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0644\u0643\u0644 \u0645\u0646\u0647\u0645\u0627 <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-581\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-17-255x300.png\" alt=\"\" width=\"569\" height=\"669\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-17-255x300.png 255w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-17.png 485w\" sizes=\"auto, (max-width: 569px) 100vw, 569px\" \/><\/span><\/p>\n<figure id=\"attachment_582\" aria-describedby=\"caption-attachment-582\" style=\"width: 521px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-582\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-300x99.jpg\" alt=\"\u0627\u0644\u0634\u0643\u0644 (4) \u064a\u0648\u0636\u062d \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 : (a) \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646\u060c (b) \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u060c (c) \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643\u060c (d) \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629\" width=\"521\" height=\"172\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-300x99.jpg 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-1024x337.jpg 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-768x253.jpg 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1.jpg 1366w\" sizes=\"auto, (max-width: 521px) 100vw, 521px\" \/><figcaption id=\"caption-attachment-582\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 (4) \u064a\u0648\u0636\u062d \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643: (a) \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646\u060c (b) \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u060c (c) \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643\u060c (d) \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0644\u0649 \u062d\u062f\u0629 \u0648\u0630\u0644\u0643 \u062d\u0633\u0628 \u0646\u0638\u0631\u064a\u0629 \u0627\u0644\u0628\u0627\u062d\u062b Lu \u0648\u0645\u0646 \u062b\u0645\u0651 \u0638\u0647\u0648\u0631 \u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0642\u0645\u062a\u064a\u0646 \u064a\u0639\u062f \u0645\u0624\u0634\u0631\u0627\u064b \u0639\u0644\u0649 \u0642\u062f\u0631\u0629 \u0647\u0630\u0627 \u0627\u0644\u0645\u0632\u064a\u062c \u0639\u0644\u0649 \u062a\u0634\u0643\u064a\u0644 \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629.<sup>13<\/sup> \u0648\u0643\u0630\u0644\u0643 \u064a\u0648\u0636\u062d \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0628\u0646\u0633\u0628\u0629 (1:1) \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0642\u0645\u0629 \u062d\u0627\u062f\u0629 \u0646\u0627\u0634\u0631\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 99.11 \u00ba\u0645 \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0642\u0645\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629 \u0628\u064a\u0646 \u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0648\u0647\u0630\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0628\u0627\u062d\u062b Chow.<sup>14 <\/sup><\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0643\u0630\u0644\u0643 \u064a\u0648\u0636\u062d \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0628\u0646\u0633\u0628\u0629 (1:1) \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0642\u0645\u0629 \u062d\u0627\u062f\u0629 \u0646\u0627\u0634\u0631\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 99.07 \u00ba\u0645 \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0642\u0645\u0629 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629 \u0628\u064a\u0646 \u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0625\u0644\u0627 \u0623\u0646\u0647 \u0646\u0644\u0627\u062d\u0638 \u0638\u0647\u0648\u0631 \u0642\u0645\u0645 \u0639\u0631\u064a\u0636\u0629 \u0625\u0636\u0627\u0641\u064a\u0629 \u0639\u0646\u062f 73.68 \u00ba \u0645 \u0648 87.89 \u00ba \u0645 \u0643\u0645\u0624\u0634\u0631 \u0639\u0644\u0649 \u0639\u062f\u0645 \u0646\u0642\u0627\u0648\u0629 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0628\u0637\u064a\u0626\u0629. \u0628\u064a\u0646\u0645\u0627 \u0641\u064a \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 (\u0627\u0644\u0634\u0643\u0644 6) \u0646\u0644\u0627\u062d\u0638 \u0638\u0647\u0648\u0631 \u0642\u0645\u0629 \u0648\u062d\u064a\u062f\u0629 \u0646\u0627\u0634\u0631\u0629 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 153.84 \u00ba \u0645 \u062a\u0648\u0627\u0641\u0642 \u0627\u0646\u0635\u0647\u0627\u0631 \u0647\u0630\u0647 \u0627\u0644\u0645\u0627\u062f\u0629 .<sup>15<\/sup> \u0623\u0645\u0627 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u00a0 \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0628\u0646\u0633\u0628\u0629 (1:1) \u064a\u0638\u0647\u0631 \u0642\u0645\u062a\u064a\u0646\u00a0 \u0639\u0646\u062f 109.28 \u00ba\u0645 \u0648 142.44 \u00ba\u0645 \u062d\u064a\u062b \u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0623\u0648\u0644\u0649 \u0627\u0646\u0635\u0647\u0627\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629 \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0632\u064a\u062c \u0623\u0635\u0647\u0631\u064a \u0648 \u0648\u0645\u0646 \u062b\u0645\u0651 \u0641\u0625\u0646\u0651 \u0647\u0630\u0647 \u0627\u0644\u0645\u0632\u064a\u062c \u0642\u0627\u062f\u0631 \u0639\u0644\u0649 \u062a\u0634\u0643\u064a\u0644 \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0648\u0641\u0642\u0627\u064b\u00a0 \u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0628\u0627\u062d\u062b\u00a0 Lu.<sup>13<\/sup> \u0625\u0644\u0627 \u0623\u0646\u0647 \u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0645\u062e\u0637\u0637 \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629 (\u0627\u0644\u0634\u0643\u0644 6) \u0646\u0644\u0627\u062d\u0638 \u0638\u0647\u0648\u0631 \u0642\u0645\u062a\u064a\u0646 \u0646\u0627\u0634\u0631\u062a\u064a\u0646 \u0644\u0644\u062d\u0631\u0627\u0631\u0629\u00a0 \u0639\u0646\u062f \u0627\u0644\u062f\u0631\u062c\u0629 109.45\u00ba\u0645 \u0648 136.28\u00ba\u0645 \u0648\u0647\u0630\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0639\u062f\u0645 \u062a\u0634\u0643\u0644 \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u062a\u0628\u062e\u064a\u0631 \u0627\u0644\u0645\u0630\u064a\u0628 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0645\u0639 \u0627\u062d\u062a\u0645\u0627\u0644 \u062a\u0634\u0643\u0644\u0647\u0627 \u0628\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0635\u0647\u0631 \u0644\u0642\u062f\u0631\u0629 \u0647\u0630\u0627 \u0627\u0644\u0645\u0632\u064a\u062c \u0639\u0644\u0649 \u062a\u0634\u0643\u064a\u0644 \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0648\u0641\u0642 \u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0628\u0627\u062d\u062b Lu.<\/span><\/p>\n<figure id=\"attachment_583\" aria-describedby=\"caption-attachment-583\" style=\"width: 434px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-583\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-300x289.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (5) \u064a\u0648\u0636\u062d \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629\" width=\"434\" height=\"418\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-300x289.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2.png 369w\" sizes=\"auto, (max-width: 434px) 100vw, 434px\" \/><figcaption id=\"caption-attachment-583\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 (5) \u064a\u0648\u0636\u062d \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_584\" aria-describedby=\"caption-attachment-584\" style=\"width: 456px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-584\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-1-300x256.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (6) \u064a\u0648\u0636\u062d \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648 \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629\" width=\"456\" height=\"389\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-1-300x256.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-1.png 367w\" sizes=\"auto, (max-width: 456px) 100vw, 456px\" \/><figcaption id=\"caption-attachment-584\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 (6) \u064a\u0648\u0636\u062d \u0627\u0644\u0645\u0633\u062d \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u062a\u0641\u0627\u0636\u0644\u064a \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648 \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0635 \u0645\u0639\u062f\u0644 \u0627\u0644\u0630\u0648\u0628\u0627\u0646:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0628\u0646\u0633\u0628\u0629 (1:1) (\u0627\u0644\u0634\u0643\u0644 7) \u0646\u0644\u0627\u062d\u0638 \u0632\u064a\u0627\u062f\u0629 \u0648\u0627\u0636\u062d\u0629 \u0641\u064a \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0641\u064a \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0628\u0634\u0643\u0644 \u064a\u0639\u062a\u062f \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u062b\u0642\u0629 (P&lt;0.05) \u0644\u0643\u0648\u0646 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0639\u0627\u0645\u0644\u0627\u064b \u0645\u0628\u0644\u0644\u0627\u064b \u064a\u0645\u0646\u0639 \u062a\u0643\u062a\u0644 \u0648\u062a\u0631\u0627\u0643\u0645 \u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646.<sup>16<\/sup> \u0623\u0645\u0627 \u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631\u0629 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629 (\u0627\u0644\u0634\u0643\u0644 7)\u00a0 \u0646\u0644\u0627\u062d\u0638 \u0632\u064a\u0627\u062f\u0629 \u0648\u0627\u0636\u062d\u0629 \u0639\u0646\u062f \u0627\u0644\u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 5 \u0648 10 \u0648 15 \u0648 20 \u062f\u0642\u064a\u0642\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0648\u0647\u0630\u0627 \u0628\u0633\u0628\u0628 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629\u00a0 \u0648 \u0642\u062f \u0643\u0627\u0646\u062a \u0627\u0644\u0632\u064a\u0627\u062f\u0629 \u0623\u0643\u062b\u0631 \u0648\u0636\u0648\u062d\u0627\u064b \u0641\u064a \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0645\u0646 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0647\u0630\u0627 \u0628\u0633\u0628\u0628 \u0623\u0646 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0623\u0643\u062b\u0631 \u0646\u0642\u0627\u0648\u0629 \u0641\u064a \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u0645\u0627 \u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0645\u0639 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0628\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u0628\u0643 \u0628\u0646\u0633\u0628\u0629 (1:1) (\u0627\u0644\u0634\u0643\u0644 8) \u0646\u0644\u0627\u062d\u0638 \u0638\u0647\u0648\u0631 \u0632\u064a\u0627\u062f\u0629 \u0641\u0642\u0637 \u0639\u0646\u062f \u0627\u0644\u0632\u0645\u0646 5 \u062f\u0642\u064a\u0642\u0629 \u062b\u0645 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0628\u0644\u0648\u0631\u0629 \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u062b\u0645 \u0646\u0644\u0627\u062d\u0638 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u062c\u0648\u0647\u0631\u064a\u0629 \u0641\u064a \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0648\u0647\u0630\u0627 \u064a\u0639\u0648\u062f \u0625\u0644\u0649 \u0642\u0644\u0629 \u0627\u0646\u062d\u0644\u0627\u0644\u064a\u0629 \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643\u00a0 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u0645\u0646 \u062b\u0645\u0651 \u062d\u0627\u0641\u0638 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0639\u0644\u0649 \u0645\u0639\u062f\u0644 \u0627\u0646\u062d\u0644\u0627\u0644\u0647. \u0648 \u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 (\u0627\u0644\u0634\u0643\u0644 8) \u0646\u0644\u0627\u062d\u0638 \u0627\u0646\u062e\u0641\u0627\u0636 \u0648\u0627\u0636\u062d \u0641\u064a \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0639\u0646\u062f \u0627\u0644\u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u0632\u0645\u0646\u064a\u0629: 15 \u0648 20 \u0648 30 \u0648 45 \u062f\u0642\u064a\u0642\u0629 \u0623\u0645\u0627 \u0641\u064a \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0646\u0644\u0627\u062d\u0638 \u0632\u064a\u0627\u062f\u0629 \u0648\u0627\u0636\u062d\u0629 \u0641\u064a \u0627\u0644\u0632\u0645\u0646 5 \u062f\u0642\u064a\u0642\u0629 \u062b\u0645 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0639\u062f\u0644 \u0627\u0644\u0630\u0648\u0628\u0627\u0646 \u0641\u064a \u0627\u0644\u0641\u0648\u0627\u0635\u0644 10 \u064815\u0648 20 \u0648 30 \u0644\u064a\u062a\u0637\u0627\u0628\u0642 \u0641\u064a \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0645\u0639 \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0647\u0630\u0647 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0642\u062f \u062a\u0643\u0648\u0646 \u0628\u0633\u0628\u0628 \u062a\u063a\u064a\u0631 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0628\u0644\u0648\u0631\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 polymorphism.<\/span><\/p>\n<figure id=\"attachment_585\" aria-describedby=\"caption-attachment-585\" style=\"width: 472px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-585\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-2-300x268.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (7) \u064a\u0648\u0636\u062d \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u0646 \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629\" width=\"472\" height=\"422\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-2-300x268.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-2.png 387w\" sizes=\"auto, (max-width: 472px) 100vw, 472px\" \/><figcaption id=\"caption-attachment-585\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 (7) \u064a\u0648\u0636\u062d \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u0646 \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_586\" aria-describedby=\"caption-attachment-586\" style=\"width: 472px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-586\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-3-300x291.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 (8) \u064a\u0648\u0636\u062d \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629\" width=\"472\" height=\"458\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-3-300x291.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/2-3.png 385w\" sizes=\"auto, (max-width: 472px) 100vw, 472px\" \/><figcaption id=\"caption-attachment-586\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 (8) \u064a\u0648\u0636\u062d \u0645\u0639\u062f\u0644 \u0630\u0648\u0628\u0627\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0646\u0642\u064a \u0648\u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0645\u062a\u062d\u0631\u0631 \u0645\u0646 \u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648\u0627\u0644\u0645\u0632\u064a\u062c \u0627\u0644\u0645\u0648\u0627\u0641\u0642 \u0627\u0644\u0645\u0628\u0644\u0648\u0631 \u0628\u0644\u0648\u0631\u0629 \u0628\u0637\u064a\u0626\u0629 \u0648\u0633\u0631\u064a\u0639\u0629<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong><strong>Conclusions<\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0646\u0627\u0642\u0634\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0636\u064a\u0631 \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0639 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0648\u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0628\u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u0637\u0631\u064a\u0642\u062a\u064a\u00a0 \u062a\u0628\u062e\u064a\u0631 \u0627\u0644\u0645\u0630\u064a\u0628 \u0627\u0644\u0628\u0637\u064a\u0626\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0639\u0629. \u0623\u0638\u0647\u0631 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u0643\u0648\u064a\u0646 \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u062d\u064a\u062b \u0644\u0645 \u062a\u0639\u0637 \u0627\u0644\u0641\u062d\u0648\u0635 \u0627\u0644\u0645\u062c\u0631\u0627\u0629 \u0645\u0624\u0634\u0631\u0627\u062a \u0642\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u062d\u062a\u0645\u0627\u0644 \u062a\u0643\u0648\u0646 \u0628\u0644\u0648\u0631\u0629 \u062a\u0634\u0627\u0631\u0643\u064a\u0629\u00a0 \u0645\u0639 \u062d\u0645\u0636 \u0627\u0644\u0623\u062f\u064a\u0628\u064a\u0643 \u0648\u0641\u0642 \u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0628\u064a\u0646\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0627\u0644\u0645\u062d\u0636\u0631\u0629 \u0645\u0639 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f\u00a0 \u0648\u0641\u0642 \u0637\u0631\u064a\u0642\u062a\u064a \u0627\u0644\u062a\u062d\u0636\u064a\u0631 \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u0642\u0648\u064a\u0629 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f\u0647\u0627 \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u0642 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0648 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0627\u0647\u062a\u0632\u0627\u0632\u064a\u0629 \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0625\u0638\u0647\u0627\u0631 \u0627\u0644\u0628\u0644\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u0634\u0627\u0631\u0643\u064a\u0629 \u0645\u0639 \u0627\u0644\u0646\u064a\u0643\u0648\u062a\u064a\u0646 \u0623\u0645\u064a\u062f \u0633\u0631\u0639\u0629 \u0641\u064a \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644 \u0644\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0641\u0644\u0648\u0631\u0628\u064a\u0628\u0631\u0648\u0641\u0646 \u0627\u0644\u0623\u0635\u0644.<\/span><\/p>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u064a\u062d\u062f\u062f \u062a\u0648\u062c\u0647 \u0627\u0644\u062c\u0632\u064a\u0626\u0629 \u062b\u0644\u0627\u062b\u064a \u0627\u0644\u0623\u0628\u0639\u0627\u062f \u0648\u0627\u0646\u062a\u0638\u0627\u0645\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0628\u0644\u0648\u0631\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u062e\u0648\u0627\u0635 \u0627\u0644\u062a\u0639\u0628\u0626\u0629 \u0644\u0645\u0627\u062f\u0629 \u0645\u0627 \u0643\u0627\u0644\u0643\u062b\u0627\u0641\u0629 \u0648\u0627\u0644\u0630\u0648\u0628\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0642\u0627\u0628\u0644\u064a\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 \u0648\u0627\u0644\u062b\u0628\u0627\u062a&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=240\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":582,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-240","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-132","volume-8","year-137"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=240"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/240\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/582"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}