{"id":244,"date":"2022-01-01T11:54:01","date_gmt":"2022-01-01T11:54:01","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=244"},"modified":"2024-07-21T17:14:14","modified_gmt":"2024-07-21T17:14:14","slug":"%d8%aa%d9%88%d8%a7%d8%aa%d8%b1-%d9%88%d8%ac%d9%88%d8%af-%d9%81%d9%8a%d8%b1%d9%88%d8%b3-%d8%a7%d9%84%d8%a5%d8%a8%d8%b4%d8%aa%d8%a7%d9%8a%d9%86-%d8%a8%d8%a7%d8%b1ebv-%d9%81%d9%8a-%d9%86%d8%b3%d8%ac","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=244","title":{"rendered":"\u062a\u0648\u0627\u062a\u0631 \u0648\u062c\u0648\u062f \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u0628\u0634\u062a\u0627\u064a\u0646 \u0628\u0627\u0631EBV \u0641\u064a \u0646\u0633\u062c \u0648\u0631\u0645\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0644\u0650\u0645\u0652\u0641\u064f\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0648\u0631\u064a\u064a\u0646"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction:<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0631\u062a\u0628\u0637 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u0628\u0634\u062a\u0627\u064a\u0646 \u0628\u0627\u0631 (EBV) Epstein-Barr Virus \u0628\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062e\u0628\u064a\u062b\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0648\u0644\u0645\u0641\u0648\u0645\u0629 \u0628\u064a\u0631\u0643\u064a\u062a \u0648\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0644\u0639\u0648\u0645 \u0627\u0644\u0623\u0646\u0641\u064a nasopharyngeal carcinoma <sup>(1)<\/sup>. \u0648\u064a\u0643\u0648\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0647 \u0628\u0637\u0648\u0631 \u0627\u0644\u062e\u0641\u0627\u0621 latency phase\u060c \u0648\u0645\u0639\u0638\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0628\u062d\u0627\u0644\u0629 \u0635\u0627\u0645\u062a\u0629 \u0648\u062e\u0635\u0648\u0635\u0627\u064b \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0639\u0628\u0631 \u0639\u0646 \u0627\u0644\u0623\u0646\u0632\u064a\u0645\u0627\u062a \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633 <sup>(1)<\/sup>\u060c \u0648\u064a\u064f\u0639\u0628\u0651\u0631 \u0639\u0646 \u0639\u062f\u062f \u0642\u0644\u064a\u0644 \u0641\u0642\u0637 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u062a\u064a \u062a\u0639\u0631\u0641 \u0628\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062e\u0641\u0627\u0621 latent gens\u060c \u0648\u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u062a\u0631\u0645\u0632 \u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0641\u064a\u0631\u0648\u0633\u064a\u0629 \u0623\u0648 RNA \u063a\u064a\u0631 \u0645\u062a\u0631\u062c\u0645 untranslated RNA\u060c \u062a\u0624\u062f\u064a \u0647\u0630\u0647 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u062f\u0648\u0631\u0627\u064b \u0623\u0633\u0627\u0633\u064a\u0627\u064b \u0641\u064a \u0639\u0645\u0644\u064a\u0629 \u062a\u0643\u0648\u0646 \u0627\u0644\u0648\u0631\u0645 oncogenesis. \u0648\u064a\u0631\u062a\u0628\u0637 \u0643\u0644 \u0648\u0631\u0645 \u0628\u0646\u0648\u0639 \u0645\u0639\u064a\u0646 \u0645\u0646 \u0623\u0637\u0648\u0627\u0631 \u0627\u0644\u062e\u0641\u0627\u0621.<sup> (1) <\/sup><\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0634\u0643\u0644 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 20-30% \u0645\u0646 \u0645\u062c\u0645\u0644 \u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629\u060c \u0648\u0646\u062d\u0648 1% \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u062d\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645 <sup>(2)<\/sup>\u060c \u062a\u0635\u064a\u0628 \u0628\u0634\u0643\u0644 \u0623\u0633\u0627\u0633\u064a \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 \u0648\u062a\u0642\u0633\u0645 \u0625\u0644\u0649 \u0646\u0645\u0637\u064a\u0646:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0643\u0644\u0627\u0633\u064a\u0643\u064a Hodgkin lymphoma) (cHL) classical \u0627\u0644\u0630\u064a \u064a\u0634\u0643\u0644 \u062d\u0648\u0627\u0644\u064a 95% \u0645\u0646 \u0645\u062c\u0645\u0644 \u0627\u0644\u062d\u0627\u0644\u0627\u062a<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0639\u0642\u064a\u062f\u064a \u0630\u0648 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 nodular lymphocyte predominant HL \u0648\u0647\u0648 \u0623\u0642\u0644 \u0634\u064a\u0648\u0639\u0627\u064b\u060c \u0648\u064a\u0639\u062a\u0628\u0631 \u0643\u064a\u0627\u0646\u0627\u064b \u0645\u0631\u0636\u064a\u0627\u064b \u0645\u062e\u062a\u0644\u0641\u0627\u064b\u060c \u0648\u0646\u0627\u062f\u0631\u0627\u064b \u0645\u0627 \u064a\u0631\u062a\u0628\u0637 \u0628\u0641\u064a\u0631\u0648\u0633 EBV <sup>(3)<\/sup>\u060c \u0644\u0630\u0644\u0643 \u0633\u0648\u0641 \u062a\u0642\u062a\u0635\u0631 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0639\u0644\u0649 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0643\u0644\u0627\u0633\u064a\u0643\u064a.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0643\u0644\u0627\u0633\u064a\u0643\u064a\u0629 (cHL) \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u062a\u0645\u062a\u0644\u0643 \u0646\u0645\u0637\u0627\u064b \u0646\u0633\u064a\u062c\u064a\u0627\u064b \u0641\u0631\u064a\u062f\u0627\u064b\u060c \u064a\u062a\u0645\u064a\u0632 \u0628\u0648\u062c\u0648\u062f \u0639\u062f\u062f \u0642\u0644\u064a\u0644 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u064f\u0639\u0631\u0641 \u0628\u062e\u0644\u0627\u064a\u0627 \u0631\u064a\u062f \u0633\u062a\u064a\u0631\u0646\u0628\u064a\u0631\u063a Reed\u2013Sternberg\u00a0cells (HRS) \u0636\u0645\u0646 \u0628\u064a\u0626\u0629 \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0627\u0631\u062a\u0643\u0627\u0633\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u062e\u0628\u064a\u062b\u0629<sup>(2)<\/sup>. \u062a\u0631\u062a\u0628\u0637 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u062d\u0627\u0644\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0628\u0648\u062c\u0648\u062f \u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0648\u0642\u062f \u0648\u062c\u062f \u0623\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u062f\u0627\u0621 \u0643\u062b\u0631\u0629 \u0627\u0644\u0648\u062d\u064a\u062f\u0627\u062a \u0627\u0644\u0639\u062f\u0648\u0627\u0626\u064a\u0629 infectious mononucleosis \u064a\u0632\u064a\u062f \u0645\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a \u0628\u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u062d\u0648\u0627\u0644\u064a \u062b\u0644\u0627\u062b\u0629 \u0625\u0644\u0649 \u0623\u0631\u0628\u0639\u0629 \u0623\u0636\u0639\u0627\u0641<sup>(3)<\/sup>. \u062a\u064f\u0639\u0631\u0641 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV (EBV+HL) \u0628\u0648\u062c\u0648\u062f \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 \u0627\u0644\u0648\u0631\u0645\u064a\u0629\u060c \u0648\u064a\u0643\u0648\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0628\u0637\u0648\u0631 \u0627\u0644\u062e\u0641\u0627\u0621 \u0627\u0644\u062b\u0627\u0646\u064a latency phase \u01c1 <sup>(3)<\/sup>\u060c \u0648\u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0637\u0648\u0631 \u064a\u0639\u0628\u0631 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0639\u0646:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0645\u0633\u062a\u0636\u062f \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0623\u0648\u0644 EBV nuclear antigen 1 (EBNA1) :\u0648 \u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u062f\u0646\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0644\u064a\u062d\u0627\u0641\u0638 \u0639\u0644\u0649 \u0627\u0644\u0645\u062c\u064a\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 \u0628\u062d\u0627\u0644\u0629 \u064a\u0635\u0628\u0648\u063a \u062d\u0644\u0642\u064a circular episome\u060c \u0648\u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0633\u062a\u0636\u062f \u0623\u064a\u0636\u0627\u064b \u062f\u0648\u0631 \u0641\u064a \u062a\u0646\u0633\u062e replication \u0627\u0644\u062c\u064a\u0646\u0648\u0645 genome\u060c \u0648\u0627\u0646\u0642\u0633\u0627\u0645\u0647 \u0623\u062b\u0646\u0627\u0621 \u0627\u0646\u0642\u0633\u0627\u0645 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0630\u0627\u0643\u0631\u0629 \u0627\u0644\u0628\u0627\u0626\u064a\u0629<sup>(4)<\/sup>.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u062b\u0646\u0627\u0646 \u0645\u0646 \u0627\u0644\u0631\u0646\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0627\u0644\u0635\u063a\u064a\u0631 \u0627\u0644\u0645\u08f3\u0631\u0645\u064e\u0632EBV Encoded Small RNAs (EBERs) : EBER1 \u0648 EBER2 \u0644\u0627 \u064a\u0631\u0645\u0632\u0627\u0646 \u0644\u0623\u064a \u0628\u0631\u0648\u062a\u064a\u0646 \u0641\u064a\u0631\u0648\u0633\u064a \u0644\u0643\u0646\u0647\u0645\u0627 \u0645\u0647\u0645\u0627\u0646 \u0644\u0644\u0627\u0633\u062a\u062d\u0627\u0644\u0629 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 oncogenic transformation. <sup>(4)<\/sup><\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u063a\u0634\u0627\u0626\u064a \u0627\u0644\u0645\u062e\u0641\u064a \u0627\u0644\u0623\u0648\u0644 latent membrane protein-1 (LMP-1) \u0648\u0647\u0648 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0627\u0644\u0645\u062d\u062f\u062b \u0644\u0644\u0627\u0633\u062a\u062d\u0627\u0644\u0629 main transforming protein <sup>(5)<\/sup>. \u064a\u062a\u0635\u0631\u0641 \u0628\u0648\u0635\u0641\u0647 \u062c\u064a\u0646\u0627\u064b \u0648\u0631\u0645\u064a\u0627\u064b \u0648\u0644\u0647 \u0639\u062f\u0629 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u0633\u0631\u0637\u0646\u0629\u060c \u0645\u0646\u0647\u0627 \u062a\u062d\u0631\u064a\u0636 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0645\u0648\u062a \u0627\u0644\u0645\u0628\u0631\u0645\u062c \u0645\u062b\u0644 BCL2 \u0648A20\u060c\u0648 \u064a\u0642\u0644\u062f CD 40 \u0645\u0645\u0627 \u064a\u08f3\u0641\u0639\u0644 \u0633\u0628\u064a\u0644 NF-KB \u0627\u0644\u0630\u064a \u0628\u062f\u0648\u0631\u0647 \u064a\u0641\u0639\u0644 \u062a\u0643\u0627\u062b\u0631 \u0648\u062a\u0645\u0627\u064a\u0632 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629<sup>(5)<\/sup>.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0645\u0631\u062c\u0639\u064a\u0629 \u0644\u0643\u0634\u0641 \u0648\u062c\u0648\u062f \u0641\u064a\u0631\u0648\u0633 Epstein-Barr (EBV) \u0641\u064a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0647\u064a \u062a\u062d\u0631\u064a \u0648\u062c\u0648\u062f \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u063a\u0634\u0627\u0626\u064a LMP1 \u0641\u064a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0627\u0644\u0647\u064a\u0633\u062a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u00a0 immunohistochemistry.<sup>(3). <\/sup><\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0634\u0641\u0627\u0621 \u0644\u0643\u0646 \u0646\u0633\u0628\u0629 \u062d\u062f\u0648\u062b \u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0648\u0646\u0643\u0633 \u0645\u0631\u062a\u0641\u0639\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0645\u062e\u064a\u0628\u0629 \u0644\u0644\u0622\u0645\u0627\u0644 \u0639\u0646\u062f \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 <sup>(6)<\/sup>\u060c\u0648\u062a\u0631\u0643\u0632 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0639\u0644\u0649 \u062f\u0648\u0631 \u0627\u0644\u0628\u064a\u0626\u0629 \u0627\u0644\u0645\u0643\u0631\u0648\u064a\u0629 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 Tumor Microenvironment \u0641\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u0646\u0643\u0633 \u0648\u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u060c \u0644\u0630\u0644\u0643 \u0623\u0635\u0628\u062d \u0645\u0646 \u0627\u0644\u0636\u0631\u0648\u0631\u0629 \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u0627\u0644\u0648\u0627\u0635\u0645\u0627\u062a \u0648\u0627\u0644\u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u062f\u0627\u0639\u0645\u0629 \u0644\u0644\u0628\u064a\u0626\u0629 \u0627\u0644\u0645\u0643\u0631\u0648\u064a\u0629 \u0648\u0627\u0644\u0648\u0631\u0645\u060c \u0648\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0629 \u0627\u0644\u062a\u0646\u0628\u0624\u064a\u0629 \u0644\u0647\u0627 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0641\u064a \u062a\u062d\u062f\u064a\u062f \u0625\u0646\u0630\u0627\u0631 \u0627\u0644\u0648\u0631\u0645 \u0648\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0643\u062b\u0631 \u0627\u062d\u062a\u0645\u0627\u0644\u0627\u064b \u0644\u0644\u0646\u0643\u0633 \u0648\u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0627\u0647\u0645 \u0641\u064a \u0648\u0636\u0639 \u062e\u0637\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0641\u064a \u0627\u0644\u0628\u062f\u0627\u064a\u0629 \u062a\u062a\u0646\u0627\u0633\u0628 \u0645\u0639 \u0625\u0646\u0630\u0627\u0631 \u0627\u0644\u0648\u0631\u0645\u060c \u0645\u0646 \u0627\u0644\u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0629 \u0627\u0644\u0647\u0627\u0645\u0629 \u0641\u064a\u0631\u0648\u0633EBV \u0648\u0627\u0644\u0630\u064a \u064a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0645\u0647\u0645\u0627\u064b \u0641\u064a \u062a\u0637\u0648\u0631 \u0648\u0625\u0646\u0630\u0627\u0631 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646<sup>(6)<\/sup>\u060c \u0648\u0642\u062f \u062f\u0639\u062a \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0625\u0644\u0649 \u0636\u0631\u0648\u0631\u0629 \u062f\u0631\u0627\u0633\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0641\u064a\u0631\u0648\u0633EBV \u0628\u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0648\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633 \u0628\u0643\u0644 \u0628\u0644\u062f \u0636\u0645\u0646 \u0627\u0644\u0645\u0631\u0627\u0643\u0632 \u0627\u0644\u0628\u062d\u062b\u064a\u0629 <sup>(6)<\/sup>\u060c \u062e\u0635\u0648\u0635\u0627 \u0628\u0639\u062f \u0638\u0647\u0648\u0631 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u062d\u062f\u064a\u062b\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u062a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0636\u0645\u0646 \u0627\u0644\u0648\u0631\u0645\u060c \u0648\u0645\u0646\u0647\u0627 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u062f\u0648\u064a\u0629 \u0645\u062d\u0641\u0632\u0629 \u0644\u0644\u0637\u0648\u0631 \u0627\u0644\u062d\u0627\u0644 \u0627\u0644\u062a\u0646\u0627\u0633\u062e\u064a \u0644\u0641\u064a\u0631\u0648\u0633 EBV \u0628\u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0645\u0639 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a<sup>(7,8)<\/sup>. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0623\u0628\u062d\u0627\u062b \u062d\u062f\u064a\u062b\u0629 \u062d\u0648\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0635\u063a\u064a\u0631\u0629 \u062a\u0631\u062a\u0628\u0637 \u0628\u0634\u0643\u0644 \u0646\u0648\u0639\u064a \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u00a0EBNA1 \u0648\u062a\u062b\u0628\u0637\u0647 \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629<sup> (9)<\/sup>. \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0647\u064a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0641\u064a \u0633\u0648\u0631\u064a\u0629 \u062d\u0648\u0644 \u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 EBV \u0641\u064a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0636\u0645\u0646 \u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u0645\u062c\u062a\u0645\u0639 \u0627\u0644\u0633\u0648\u0631\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0628\u062d\u062b<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u0631\u0627\u0633\u0629 \u0645\u0642\u0637\u0639\u064a\u0629 \u0627\u0633\u062a\u0628\u0627\u0642\u064a\u0629 cross-sectional study prospective\u060c \u062a\u0633\u062a\u0647\u062f\u0641 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u062c\u0631\u064a\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c SPSS \u0627\u0644\u0625\u0635\u062f\u0627\u0631 25\u060c \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 Fisher Exact Test \u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a\u060c \u062d\u062f\u062f\u062a \u0642\u064a\u0645\u0629 P \u0623\u0635\u063a\u0631 \u0645\u0646 0.05 \u0644\u0644\u0627\u0639\u062a\u062f\u0627\u062f \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0642 <\/strong><strong>Materials and Methods<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>1-\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0636\u0645\u062a \u0627\u0644\u0639\u064a\u0646\u0629 60 \u0645\u0631\u064a\u0636\u0627\u064b \u0645\u0646 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0648\u0627\u0644\u0645\u0631\u0627\u062c\u0639\u064a\u0646 \u0644\u0623\u062d\u062f \u0627\u0644\u0645\u0631\u0627\u0643\u0632 \u0627\u0644\u062a\u0627\u0644\u064a\u0629:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0623\u0633\u062f \u0627\u0644\u062c\u0627\u0645\u0639\u064a<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0645\u0648\u0627\u0633\u0627\u0629<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif;\">\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u062e\u062a\u064a\u0631 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0634\u062e\u0635\u064a\u0646 \u062d\u062f\u064a\u062b\u0627\u064b \u0628\u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0642\u0628\u0644 \u0627\u0644\u0628\u062f\u0621 \u0628\u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0628\u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0648\u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u062e\u0632\u0639\u0629 \u0645\u0646 \u0627\u0644\u0648\u0631\u0645 \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u062a\u0634\u062e\u064a\u0635 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u062d\u0633\u0628 \u062a\u0635\u0646\u064a\u0641 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 <sup>(10)<\/sup>\u060c\u062a\u0645 \u0627\u0646\u062a\u0642\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0633\u064a\u062e\u0636\u0639\u0648\u0646 \u0644\u0646\u0641\u0633 \u0627\u0644\u062e\u0637\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 ABVD \u0648\u0627\u0644\u062a\u064a \u062a\u0636\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 : doxorubicin bleomycin \u0648vinblastine \u0648dacarbazine.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>2- \u062c\u0645\u0639 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062c\u0631\u0649 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0646 \u0633\u062c\u0644\u0627\u062a\u0647\u0645 \u0627\u0644\u0645\u0631\u0636\u064a\u0629\u060c \u0648\u0630\u0644\u0643 \u0628\u0639\u062f \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0645\u0633\u062a\u0646\u064a\u0631\u0629 \u0645\u0646\u0647\u0645. \u0648\u0643\u0630\u0644\u0643 \u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u062c\u0647\u0627\u062a \u0627\u0644\u0645\u0639\u0646\u064a\u0629 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u064a\u0627\u062a \u0648\u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0623\u062e\u0644\u0627\u0642\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u0635\u064a\u062f\u0644\u0629. \u062e\u0636\u0639 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u062a\u0642\u064a\u0645 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0648\u0641\u0642\u064b\u0627 \u0644\u0646\u0638\u0627\u0645 \u062a\u0635\u0646\u064a\u0641 Ann Arbor Staging <sup>(<\/sup><sup>11<\/sup><sup>)<\/sup>\u060c \u0648\u0647\u0648 \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u062f\u0631\u062c\u0629 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0648\u0631\u0645. \u062a\u0645\u062a \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0633\u062c\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0644\u062a\u0642\u064a\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0648\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0641\u0642\u064b\u0627 \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u062f\u0648\u0644\u064a\u0629 \u0644\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 <sup>(11) <\/sup>\u0643\u0644 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631 \u0644\u0645\u062f\u0629 24 \u0634\u0647\u0631\u0627\u064b\u060c \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0628\u062f\u0646\u064a \u0648\u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 \u0644\u0644\u0635\u062f\u0631 \u0648\u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0644\u0644\u0635\u062f\u0631 \u0648\u0627\u0644\u0628\u0637\u0646. \u062a\u0645 \u062a\u0635\u0646\u064a\u0641 \u0627\u0644\u0645\u0631\u0636\u0649 \u0636\u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u062d\u0633\u0628 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629: \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0648\u0627 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0645 \u064a\u0633\u062a\u062c\u064a\u0628\u0648\u0627 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 (\u062d\u062f\u062b \u0644\u062f\u064a\u0647\u0645 \u0646\u0643\u0633 \u0623\u0648 \u062d\u062f\u062b \u0644\u062f\u064a\u0647\u0645 \u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0639\u0644\u0627\u062c).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>3- \u0627\u0644\u0627\u0639\u062a\u064a\u0627\u0646<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0623\u062e\u0630\u062a \u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u0648\u0631\u0645\u064a (\u0639\u064a\u0646\u0627\u062a \u0639\u0642\u062f\u064a\u0629) \u0645\u062b\u0628\u062a\u0629 \u0628\u0627\u0644\u0641\u0648\u0631\u0645\u0627\u0644\u064a\u0646 \u0645\u062d\u0641\u0648\u0638\u0629 \u0628\u0627\u0644\u0628\u0627\u0631\u0627\u0641\u064a\u0646 formalin-fixed paraffin-embedded (FFPE) tissue samples \u0645\u0646 \u0645\u062e\u062a\u0628\u0631 \u0627\u0644\u062a\u0634\u0631\u064a\u062d \u0627\u0644\u0645\u0631\u0636\u064a \u0641\u064a \u0643\u0644 \u0645\u0646 \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0623\u0633\u062f \u0627\u0644\u062c\u0627\u0645\u0639\u064a \u0648\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0648\u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0645\u0648\u0627\u0633\u0627\u0629. \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0648\u0627\u0642\u0639\u0629 \u0628\u064a\u0646 1\/9\/2017 \u0625\u0644\u0649 1\/1\/2019\u060c \u0623\u062c\u0631\u064a \u0627\u0644\u062a\u0644\u0648\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0627\u0644\u0647\u064a\u0633\u062a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 immunohistochemistry stains \u0641\u064a \u0645\u062e\u062a\u0628\u0631 \u0627\u0644\u062a\u0634\u0631\u064a\u062d \u0627\u0644\u0645\u0631\u0636\u064a \u0641\u064a \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0623\u0633\u062f \u0627\u0644\u062c\u0627\u0645\u0639\u064a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>4-\u0627\u0644\u0637\u0631\u0627\u0626\u0642 <\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0643\u0634\u0641 \u0648\u062c\u0648\u062f \u0641\u064a\u0631\u0648\u0633 <\/strong><strong>EBV<\/strong><strong> \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u0648\u0631\u0645\u064a \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 <\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0643\u062a\u0634\u0641 \u0648\u062c\u0648\u062fEBV \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u0648\u0631\u0645\u064a \u0627\u0644\u0645\u062b\u0628\u062a\u0629 \u0628\u0627\u0644\u0641\u0648\u0631\u0645\u0627\u0644\u064a\u0646 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062d\u0631\u064a \u0648\u062c\u0648\u062f LMP1 \u0641\u064a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0627\u0644\u0647\u064a\u0633\u062a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 immunohistochemistry\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0636\u062f\u0627\u062f \u0646\u0648\u0639\u064a\u0629 \u0636\u062f \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a LMP1 \u0645\u0646 \u0634\u0631\u0643\u0629 (Bio SB, Germany)\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u062a\u064a\u062f\u0629 \u0644\u0643\u0634\u0641 \u0627\u0644\u0623\u0636\u062f\u0627\u062f \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 Mouse\/Rabbit PolyDetector DAB HRP Brown detection system \u0645\u0646 \u0634\u0631\u0643\u0629 Bio SB, Germany))\u060c \u062a\u0645 \u0627\u0644\u0639\u0645\u0644 \u062d\u0633\u0628 \u062a\u0639\u0644\u064a\u0645\u0627\u062a \u0627\u0644\u0634\u0631\u0643\u0629 \u0627\u0644\u0645\u0635\u0646\u0639\u0629. \u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u0639\u062a\u064a\u062f\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0634\u0627\u0647\u062f \u0625\u064a\u062c\u0627\u0628\u064a\u060c \u0648\u0634\u0627\u0647\u062f \u0633\u0644\u0628\u064a \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u064a\u0646\u0627\u062a \u0646\u0633\u064a\u062c\u064a\u0629 \u0633\u0644\u064a\u0645\u0629 \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 \u0634\u0627\u0647\u062f \u0633\u0644\u0628\u064a. \u0644\u0627 \u064a\u062a\u0645 \u062a\u0637\u0628\u064a\u0642 \u0647\u0630\u0647 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646 \u0641\u064a \u0633\u0648\u0631\u064a\u0629 \u0643\u0627\u062e\u062a\u0628\u0627\u0631 \u0631\u0648\u062a\u064a\u0646\u064a \u0644\u0643\u0634\u0641 \u0627\u0644\u0625\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0641\u064a\u0631\u0648\u0633 EBV.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>3-\u0627\u0644\u0646\u062a\u0627\u0626\u062c:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 60 \u0639\u064a\u0646\u0629 \u0646\u0633\u064a\u062c \u0648\u0631\u0645\u064a \u0645\u0623\u062e\u0648\u0630\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646\u060c \u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 4 \u0625\u0644\u0649 60 \u0633\u0646\u0629\u060c \u062a\u0648\u0632\u0639\u062a \u0639\u0644\u0649 \u0641\u0626\u062a\u064a\u0646 \u0639\u0645\u0631\u064a\u062a\u064a\u0646: \u0627\u0644\u0641\u0626\u0629 \u0627\u0644\u0639\u0645\u0631\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 (4-12)\u0633\u0646\u0629 \u0628\u0644\u063a \u0639\u062f\u062f\u0647\u0627 (20\/60\u060c 33.3%) \u0648\u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u0623\u0639\u0645\u0627\u0631 \u0647\u0630\u0647 \u0627\u0644\u0641\u0626\u0629 8 \u0633\u0646\u0648\u0627\u062a\u060c \u0648\u0627\u0644\u0641\u0626\u0629 \u0627\u0644\u0639\u0645\u0631\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (40-60) \u0633\u0646\u0629 \u0628\u0644\u063a \u0639\u062f\u062f\u0647\u0627 (40\/60\u060c 66.7%) \u0648\u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u0623\u0639\u0645\u0627\u0631\u0647\u0645 50 \u0633\u0646\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0625\u0635\u0627\u0628\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u062d\u0633\u0628 \u0627\u0644\u062c\u0646\u0633 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u062a\u0628\u064a\u0646 \u0623\u0646 \u0639\u062f\u062f \u0627\u0644\u0630\u0643\u0648\u0631 (37\/60\u060c 61.7%)\u060c \u0648\u0639\u062f\u062f \u0627\u0644\u0625\u0646\u0627\u062b (23\/60\u060c 38.3%). <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0648\u0632\u0639\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u062d\u0633\u0628 \u0627\u0644\u0646\u0645\u064a\u0637 \u0627\u0644\u0646\u0633\u064a\u062c\u064a histologic subtype \u0625\u0644\u0649\u00a0 :(25\/60\u060c 41.7%) \u0645\u0631\u064a\u0636 \u0643\u0627\u0646\u062a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0644\u062f\u064a\u0647\u0645 \u0645\u0646 \u0646\u0645\u064a\u0637 \u0627\u0644\u062a\u0635\u0644\u0628 \u0627\u0644\u0639\u0642\u064a\u062f\u064a \u00a0Nodular sclerosis (NC)\u060c \u0648(22\/60\u060c 36.7%) \u0645\u0631\u064a\u0636 \u0643\u0627\u0646\u062a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0644\u062f\u064a\u0647\u0645 \u0645\u0646 \u0627\u0644\u0646\u0645\u064a\u0637 \u0645\u062e\u062a\u0644\u0637 \u0627\u0644\u062e\u0644\u064a\u0648\u064a\u0629 Mixed cellularity (MC)\u060c \u0648(8\/60\u060c 13.3%) \u0645\u0631\u064a\u0636 \u0643\u0627\u0646\u062a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0644\u062f\u064a\u0647\u0645 \u0645\u0646 \u0627\u0644\u0646\u0645\u064a\u0637 \u0627\u0644\u063a\u0646\u064a \u0628\u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0627\u062a Lymphocyte-Rich (LR)\u060c \u0648(5\/60\u060c 8.3%) \u0645\u0631\u064a\u0636 \u0643\u0627\u0646\u062a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0644\u062f\u064a\u0647\u0645 \u0645\u0646 \u0627\u0644\u0646\u0645\u064a\u0637 \u0646\u0636\u0648\u0628 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0627\u062a (Lymphocyte-depletion (LD. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633\u062a \u0646\u0633\u0628\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0625\u0635\u0627\u0628\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0628\u0641\u064a\u0631\u0648\u0633 EBV \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0625\u064a\u062c\u0627\u0628\u064a\u064a LMP1 \u0648\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u0644\u0648\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0644\u0628\u0631\u0648\u062a\u064a\u0646 LMP1 \u0641\u064a \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u0648\u0631\u0645\u064a \u0644\u0645\u0631\u0636\u0649 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0648\u062c\u0648\u062f \u0625\u064a\u062c\u0627\u0628\u064a\u0629 LMP1 \u00a0\u0641\u064a (25\/60\u060c 41.7% ) \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 \u0627\u0644\u0645\u0641\u062d\u0648\u0635\u0629\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a 41.7% \u0645\u0646 \u062d\u0627\u0644\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0647\u064a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 EBV\u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a LMP1 \u0633\u0644\u0628\u064a\u0629 \u0641\u064a (35\/60\u060c 58.3%) \u0645\u0646 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0627\u0644\u0645\u0641\u062d\u0648\u0635\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0639\u062f \u062d\u0627\u0644\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u0628\u064a\u0634\u062a\u0627\u064a\u0646 \u0628\u0627\u0631 \u0641\u064a \u062d\u0627\u0644 \u0623\u0628\u062f\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 (HRS) \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u062d\u0628\u064a\u0628\u064a\u0629 \u0647\u064a\u0648\u0644\u064a\u0629 \u0623\u0648 \u063a\u0634\u0627\u0626\u064a\u0629 \u0644\u062a\u0644\u0648\u064a\u0646 LMP1 \u0628\u0644\u0648\u0646 \u0628\u0646\u064a. \u0627\u0644\u0634\u0643\u0644 (1) <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u062a\u0639\u062f \u062d\u0627\u0644\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0644\u0628\u064a\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u0628\u064a\u0634\u062a\u0627\u064a\u0646 \u0628\u0627\u0631 \u0641\u064a \u062d\u0627\u0644 \u0644\u0645 \u062a\u0638\u0647\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 (HRS) \u0623\u064a \u062a\u0644\u0648\u064a\u0646. \u0627\u0644\u0634\u0643\u0644 (2)<\/span><\/p>\n<figure id=\"attachment_558\" aria-describedby=\"caption-attachment-558\" style=\"width: 491px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-558\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-300x287.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 1: \u0627\u0644\u062a\u0644\u0648\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0644\u0640 LMP1\u060c \u0639\u064a\u0646\u0629 \u0645\u0646 \u0639\u064a\u0646\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629: \u0623\u0628\u062f\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 (HRS) \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u062d\u0628\u064a\u0628\u064a\u0629 \u0647\u064a\u0648\u0644\u064a\u0629 \u0648\u063a\u0634\u0627\u0626\u064a\u0629 \u0644\u062a\u0644\u0648\u064a\u0646 LMP1 \u0638\u0647\u0631 \u0628\u0644\u0648\u0646 \u0628\u0646\u064a. \u064a\u062f\u0644 \u0639\u0644\u0649 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0627\u0644\u062a\u0643\u0628\u064a\u0631 \u0627\u0644\u0623\u0635\u0644\u064a \u00d7400\" width=\"491\" height=\"470\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-300x287.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1.png 310w\" sizes=\"auto, (max-width: 491px) 100vw, 491px\" \/><figcaption id=\"caption-attachment-558\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 1: \u0627\u0644\u062a\u0644\u0648\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0644\u0640 LMP1\u060c \u0639\u064a\u0646\u0629 \u0645\u0646 \u0639\u064a\u0646\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629: \u0623\u0628\u062f\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 (HRS) \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u062d\u0628\u064a\u0628\u064a\u0629 \u0647\u064a\u0648\u0644\u064a\u0629 \u0648\u063a\u0634\u0627\u0626\u064a\u0629 \u0644\u062a\u0644\u0648\u064a\u0646 LMP1 \u0638\u0647\u0631 \u0628\u0644\u0648\u0646 \u0628\u0646\u064a. \u064a\u062f\u0644 \u0639\u0644\u0649 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0627\u0644\u062a\u0643\u0628\u064a\u0631 \u0627\u0644\u0623\u0635\u0644\u064a \u00d7400<\/span><\/strong><\/figcaption><\/figure>\n<figure id=\"attachment_559\" aria-describedby=\"caption-attachment-559\" style=\"width: 487px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-559\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-1.png\" alt=\"\u0627\u0644\u0634\u0643\u0644 2: \u0627\u0644\u062a\u0644\u0648\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0644\u0640 LMP1\u060c \u0639\u064a\u0646\u0629 \u0645\u0646 \u0639\u064a\u0646\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629: \u0644\u0645 \u062a\u0638\u0647\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 (HRS) \u0623\u064a \u0644\u0648\u0646 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0633\u0644\u0628\u064a\u0629 LMP1 \u0648\u0645\u0646 \u062b\u0645\u0651 \u0633\u0644\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0627\u0644\u062a\u0643\u0628\u064a\u0631 \u0627\u0644\u0623\u0635\u0644\u064a \u00d7400\" width=\"487\" height=\"427\" \/><figcaption id=\"caption-attachment-559\" class=\"wp-caption-text\"><strong><span style=\"font-family: 'times new roman', times, serif;\">\u0627\u0644\u0634\u0643\u0644 2: \u0627\u0644\u062a\u0644\u0648\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0644\u0640 LMP1\u060c \u0639\u064a\u0646\u0629 \u0645\u0646 \u0639\u064a\u0646\u0627\u062a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629: \u0644\u0645 \u062a\u0638\u0647\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 (HRS) \u0623\u064a \u0644\u0648\u0646 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0633\u0644\u0628\u064a\u0629 LMP1 \u0648\u0645\u0646 \u062b\u0645\u0651 \u0633\u0644\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0627\u0644\u062a\u0643\u0628\u064a\u0631 \u0627\u0644\u0623\u0635\u0644\u064a \u00d7400<\/span><\/strong><\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0648\u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0648\u0627\u0644\u0639\u0645\u0631\u060c \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0639\u0645\u0631\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 (\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0635\u063a\u0627\u0631) \u0623\u0646 (13\/20\u060c 65%) \u0639\u064a\u0646\u0629 \u0643\u0627\u0646\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u060c \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 (7\/20\u060c 35%)\u0639\u064a\u0646\u0629 \u0643\u0627\u0646\u062a \u0633\u0644\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633. \u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0639\u0645\u0631\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u0628\u0627\u0631) \u0623\u0646 (12\/40\u060c 30%) \u0643\u0627\u0646\u062a \u0639\u064a\u0646\u0627\u062a\u0647\u0645 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 (28\/40\u060c 70%)\u0639\u064a\u0646\u0629 \u0643\u0627\u0646\u062a \u0633\u0644\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u060c \u0648\u0645\u0646 \u062b\u0645\u0651 \u0646\u0633\u0628\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0645\u0639 \u0641\u064a\u0631\u0648\u0633 EBV \u0643\u0627\u0646\u062a \u0623\u0639\u0644\u0649 \u0639\u0646\u062f \u0627\u0644\u0623\u0637\u0641\u0627\u0644. \u0648\u0628\u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0627\u0633\u062a\u0642\u0644\u0627\u0644 Fisher Exact Tes \u062a\u0628\u064a\u0646 \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0648\u0627\u0644\u0623\u0639\u0645\u0627\u0631 \u0627\u0644\u0635\u063a\u064a\u0631\u0629\u060c (p=0.01). <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633\u062a \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0648\u0627\u0644\u062c\u0646\u0633\u060c \u0648\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u0643\u0648\u0631 \u0623\u0646 (17\/37\u060c 45.9%) \u0639\u064a\u0646\u0629 \u0643\u0627\u0646\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u060c \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 (20\/37\u060c54.1%) \u0639\u064a\u0646\u0629 \u0643\u0627\u0646\u062a \u0633\u0644\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633. \u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0625\u0646\u0627\u062b \u0623\u0646 (8\/23\u060c 34.8%) \u0639\u064a\u0646\u0629 \u0643\u0627\u0646\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u060c \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 (15\/23\u060c 65.2%) \u0639\u064a\u0646\u0629 \u0643\u0627\u0646\u062a \u0633\u0644\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633. \u062d\u0633\u0628 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0646\u062c\u062f \u0623\u0646 \u0646\u0633\u0628\u0629 \u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0630\u0643\u0648\u0631 \u0628\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u064a\u0628\u0634\u062a\u0627\u064a\u0646 \u0628\u0627\u0631 \u0643\u0627\u0646\u062a \u0623\u0639\u0644\u0649 \u0645\u0646 \u0645\u062b\u064a\u0644\u062a\u0647\u0627 \u0639\u0646\u062f \u0627\u0644\u0625\u0646\u0627\u062b \u0648\u0628\u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 Fisher Exact Test \u062a\u0628\u064a\u0646 \u0623\u0646\u0647 \u0644\u0627 \u064a\u0648\u062c\u062f \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0648\u0627\u0644\u062c\u0646\u0633 (p=0.2). <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u062f\u064f\u0631\u0633\u062a \u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633EBV \u0648\u0646\u0648\u0639 \u0627\u0644\u0646\u0645\u064a\u0637 \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u060c \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 \u0646\u0633\u0628\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0641\u064a\u0631\u0648\u0633EBV \u0643\u0627\u0646\u062a \u0623\u0639\u0644\u0649 \u0645\u0639 \u0627\u0644\u0646\u0645\u064a\u0637 MC \u062d\u064a\u062b \u0628\u0644\u063a\u062a \u0646\u0633\u0628\u062a\u0647 56% \u0645\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0625\u064a\u062c\u0627\u0628\u064a\u064a EBV (14\/25)\u060c \u064a\u0644\u064a\u0647 \u0627\u0644\u0646\u0645\u064a\u0637 NS (6\/25\u060c24%)\u060c \u062b\u0645 \u0627\u0644\u0646\u0645\u064a\u0637 LR (3\/25\u060c12%)\u060c \u0648\u0627\u0644\u0646\u0645\u064a\u0637 LD (2\/25\u060c8%). \u0623\u0645\u0627 \u0639\u0646\u062f \u0645\u0631\u0636\u0649 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0644\u0628\u064a\u064a EBV \u0641\u0642\u062f \u0638\u0647\u0631 \u0627\u0644\u0646\u0645\u064a\u0637 NS \u0628\u0634\u0643\u0644 \u0623\u0643\u0628\u0631 \u0628\u0646\u0633\u0628\u0629 54.3% (19\/35)\u060c \u062a\u0644\u0627\u0647 \u0627\u0644\u0646\u0645\u064a\u0637 MC (8\/35\u060c22%)\u060c \u062b\u0645 \u0627\u0644\u0646\u0645\u064a\u0637 LR (5\/35\u060c 14.3%)\u060c \u0648\u0627\u0644\u0646\u0645\u064a\u0637 LD \u0628\u0646\u0633\u0628\u0629 (3\/35\u060c 8.6%). \u0628\u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 Fisher Exact Test \u062a\u0628\u064a\u0646 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 (P= 0.04) \u0628\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0645\u0639 \u0627\u0644\u0646\u0645\u064a\u0637 \u0627\u0644\u0646\u0633\u064a\u062c\u064a MC\u060c \u0643\u0645\u0627 \u0648\u062c\u062f\u0646\u0627 \u0627\u0631\u062a\u0628\u0627\u0637 NS \u0645\u0639 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u0633\u0644\u0628\u064a \u0644\u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0648\u0644\u0645 \u062a\u0638\u0647\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u062c\u0648\u062f \u0641\u0631\u0642 \u0628\u0646\u0633\u0628\u0629 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0648\u0633\u0644\u0628\u064a\u062a\u0647 \u0641\u064a \u0627\u0644\u0646\u0645\u064a\u0637 LR \u0648\u0627\u0644\u0646\u0645\u064a\u0637 LD. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0648\u0644 (1) \u0648\u0635\u0641 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062f\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u0639\u064a\u0646\u0629 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0648\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0641\u064a\u0631\u0648\u0633 EBV. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0639\u0646\u062f \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0632\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 EBV \u062d\u0633\u0628 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0635\u0646\u0641\u0629 \u0648\u0641\u0642\u0627\u064b \u0644\u0646\u0638\u0627\u0645 \u062a\u0635\u0646\u064a\u0641 Ann Arbor Staging\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0644\u0639\u0648\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u0633\u062c\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u060c \u062a\u0628\u064a\u0646 \u0623\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 EBV \u0643\u0627\u0646\u062a \u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u062a\u0642\u062f\u0645\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636 Advanced stage \u0648\u062a\u0648\u0632\u0639\u062a \u0627\u0644\u0625\u0635\u0627\u0628\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 III \u0648\u0627\u0644\u0645\u0631\u062d\u0644\u0629 IIB (18\/25\u060c 25\/7) \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u062a\u0648\u0632\u0639\u062a \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0633\u0644\u0628\u064a\u0629 EBV \u0625\u0644\u0649 35\/18)\u060c 51.4%)\u0639\u064a\u0646\u0629 \u0644\u0645\u0631\u0636\u0649 \u0643\u0627\u0646\u0648\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 Limited stage (\u0627\u0644\u0645\u0631\u062d\u0644\u0629 II ) \u0648(17\/35\u060c 48.6\u066a) \u0639\u064a\u0646\u0629 \u0644\u0645\u0631\u0636\u0649 \u0643\u0627\u0646\u0648\u0627 \u0641\u064a \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u062a\u0642\u062f\u0645\u0629 (\u0627\u0644\u0645\u0631\u062d\u0644\u0629 IIB). \u0628\u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 Fisher Exact Test \u062a\u0628\u064a\u0646 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 ( P=0) \u0628\u064a\u0646 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0648\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0642\u064a\u0651\u0645\u062a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0648\u0641\u0642\u064b\u0627 \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u062f\u0648\u0644\u064a\u0629 \u0644\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629\u060c \u0648\u0642\u0645\u0646\u0627 \u0628\u062a\u0642\u064a\u064a\u0645 \u062c\u0645\u064a\u0639 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0628\u0639\u062f \u0628\u062f\u0627\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0643\u0644 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631 \u0644\u0645\u062f\u0629 24 \u0634\u0647\u0631\u0627\u064b. \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 \u062c\u0645\u064a\u0639 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0644\u0628\u064a\u064a EBV \u0627\u0633\u062a\u062c\u0627\u0628\u0648\u0627 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0645\u0639 \u062d\u062f\u0648\u062b \u0647\u062f\u0623\u0629 (35\/35\u060c 100%). \u0639\u0644\u0649 \u0627\u0644\u0639\u0643\u0633 \u0645\u0646 \u0630\u0644\u0643\u060c \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0633\u0648\u0623<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-560\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-2-216x300.png\" alt=\"\" width=\"575\" height=\"799\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-2-216x300.png 216w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-2-737x1024.png 737w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-2-768x1067.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-2-1105x1536.png 1105w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-2-1474x2048.png 1474w\" sizes=\"auto, (max-width: 575px) 100vw, 575px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0645\u0631\u0636\u0649 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 EBV\u060c \u062d\u064a\u062b \u0628\u0644\u063a \u0639\u062f\u062f \u0645\u0631\u0636\u0649 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u0644\u0645 \u064a\u0633\u062a\u062c\u064a\u0628\u0648\u0627 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 ( 25\/13\u060c52%)\u060c \u0648\u062a\u0645\u062b\u0644\u062a \u0639\u062f\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0625\u0645\u0627 \u0628\u062d\u062f\u0648\u062b \u0646\u0643\u0633 relapsed lymphoma (8\/25\u060c \u00a032%)\u060c \u0623\u0648 \u062d\u062f\u0648\u062b \u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0639\u0644\u0627\u062c Refractory lymphoma (5\/25\u060c 20% ). \u0623\u0645\u0627 \u0639\u062f\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0648\u0627 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0645\u0639 \u062d\u062f\u0648\u062b \u0647\u062f\u0623\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 EBV \u0628\u0644\u063a (12\/25\u060c 48%)\u060c \u0648\u0645\u0646 \u0646\u0633\u0628\u0629 \u0639\u062f\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 (\u0646\u0643\u0633 \u0648\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0639\u0644\u0627\u062c) \u0643\u0627\u0646\u062a 52% \u0623\u0639\u0644\u0649 \u0645\u0646 \u0646\u0633\u0628\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0639\u0646\u062f \u0625\u064a\u062c\u0627\u0628\u064a\u064a EBV 48%\u060c \u0648\u0644\u0627 \u0648\u062c\u0648\u062f \u0644\u062d\u0627\u0644\u0627\u062a \u0648\u0641\u0627\u0629 \u0639\u0646\u062f \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0644\u0628\u064a\u064a \u0648\u0625\u064a\u062c\u0627\u0628\u064a\u064a EBV. \u0628\u062a\u0637\u0628\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 Fisher Exact Test \u062a\u0628\u064a\u0646 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 \u0628\u064a\u0646 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0648\u0639\u062f\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0641\u064a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 (P=0.03). \u0648\u0639\u0644\u0627\u0642\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u064a\u0639\u062a\u062f \u0628\u0647\u0627 \u0628\u064a\u0646 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0644\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0641\u064a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0648(P=0.01). \u064a\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0648\u0644 (2) \u062a\u0648\u0632\u0639 \u0645\u0631\u0636\u0649 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0644\u0628\u064a\u064a \u0648\u0625\u064a\u062c\u0627\u0628\u064a\u064a EBV \u0648\u0641\u0642\u0627\u064b \u0644\u062a\u0635\u0646\u064a\u0641 \u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u062e\u0644\u0627\u0644 24 \u0634\u0647\u0631\u0627\u064b. \u0643\u0645\u0627 \u064a\u0638\u0647\u0631 \u0627\u0644\u062c\u062f\u0648\u0644 (3): \u0646\u062a\u0627\u0626\u062c \u0643\u0644 \u0645\u0631\u064a\u0636 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-561\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-3-300x217.png\" alt=\"\" width=\"543\" height=\"393\" srcset=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-3-300x217.png 300w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-3-1024x740.png 1024w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-3-768x555.png 768w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-3-1536x1110.png 1536w, https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-3-2048x1480.png 2048w\" sizes=\"auto, (max-width: 543px) 100vw, 543px\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629<\/strong><strong> Discussion <\/strong><strong>:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u064a\u0648\u062c\u062f \u062b\u0644\u0627\u062b\u0629 \u0623\u0646\u0645\u0627\u0637 \u0648\u0628\u0627\u0626\u064a\u0629 epidemiological patterns \u0644\u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u062a\u062a\u0639\u0644\u0642 \u0628\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u0627\u062c\u062a\u0645\u0627\u0639\u064a\u0629 \u0648\u0627\u0644\u0627\u0642\u062a\u0635\u0627\u062f\u064a\u0629 socioeconomic development <sup>(12)<\/sup>\u060c \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0623\u0648\u0644 \u064a\u0648\u062c\u062f \u0641\u064a \u0627\u0644\u0628\u0644\u062f\u0627\u0646 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u0637\u0648\u0631\u0629 underdeveloped countries\u060c \u0648\u0641\u064a\u0647 \u062a\u0643\u0648\u0646 \u0630\u0631\u0648\u0629 \u0645\u0639\u062f\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0648\u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0639\u0646\u062f \u0627\u0644\u0630\u0643\u0648\u0631 \u0623\u0639\u0644\u0649\u060c \u0648\u0627\u0644\u0646\u0645\u064a\u0637 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0633\u0627\u0626\u062f \u0647\u0648 \u0627\u0644\u0646\u0645\u064a\u0637 \u0645\u062e\u062a\u0644\u0637 \u0627\u0644\u062e\u0644\u064a\u0648\u064a\u0629 (MC) \u0648\u0646\u0633\u0628\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0645\u0639 \u0641\u064a\u0631\u0648\u0633 EBV \u0639\u0627\u0644\u064a\u0629 ( 70-90%) \u0648\u0628\u0634\u0643\u0644 \u062e\u0627\u0635 \u0639\u0646\u062f \u0627\u0644\u0623\u0637\u0641\u0627\u0644 ( 70-95%) <sup>(12)<\/sup>. \u0623\u0645\u0627 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062b\u0627\u0646\u064a \u0641\u064a\u0648\u062c\u062f \u0641\u064a \u0627\u0644\u0628\u0644\u062f\u0627\u0646 \u0627\u0644\u0646\u0627\u0645\u064a\u0629 \u0623\u0648 \u0627\u0644\u062a\u064a \u062a\u0645\u0631 \u0628\u0645\u0631\u062d\u0644\u0629 \u0627\u0646\u062a\u0642\u0627\u0644\u064a\u0629 \u0627\u0642\u062a\u0635\u0627\u062f\u064a\u0629 developing or transitional economies\u060c \u0648\u062a\u062a\u0645\u064a\u0632 \u0628\u0646\u0633\u0628\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0645\u062a\u0648\u0633\u0637 \u0628\u0641\u064a\u0631\u0648\u0633 EBV (40-60%) \u0648\u062a\u0643\u0648\u0646 \u0646\u0633\u0628 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0639\u0646\u062f \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0645\u0631\u062a\u0641\u0639\u0629 \u0644\u0643\u0646 \u0623\u0642\u0644 \u0645\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0623\u0648\u0644 ( 50-70%)\u060c \u0648\u0627\u0644\u0646\u0645\u064a\u0637 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0633\u0627\u0626\u062f \u0647\u0648 \u0627\u0644\u0646\u0645\u064a\u0637 \u0645\u062e\u062a\u0644\u0637 \u0627\u0644\u062e\u0644\u064a\u0648\u064a\u0629 (MC) \u0623\u0648 \u0627\u0644\u062a\u0635\u0644\u0628 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\u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0628\u0644\u062f\u0627\u0646 \u0627\u0644\u0646\u0627\u0645\u064a\u0629 \u062a\u0643\u0648\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0640 EBV \u0639\u0627\u0645\u0644\u0627\u064b \u0645\u0633\u0647\u0645\u0627\u064b \u0641\u064a \u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u062f\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 <sup>(12)<\/sup>\u060c \u0648\u0639\u0646\u062f \u0645\u0642\u0627\u0631\u0646\u0629 \u0646\u0633\u0628\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 EBV \u0639\u0646\u062f \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0633\u062c\u0644\u0629 \u0628\u062f\u0631\u0627\u0633\u062a\u0646\u0627 (65%) \u0645\u0639 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u00a0\u0641\u064a \u0627\u0644\u0628\u0644\u062f\u0627\u0646 \u0627\u0644\u0645\u062c\u0627\u0648\u0631\u0629 \u0646\u062c\u062f \u0623\u0646 \u0627\u0644\u0646\u0633\u0628\u0629 \u0645\u0634\u0627\u0628\u0647\u0629 \u0644\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0633\u062c\u0644\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 Sughayer \u0641\u064a \u0627\u0644\u0623\u0631\u062f\u0646 <sup>(13)<\/sup> 2014\u0648 \u0628\u0644\u063a\u062a 68%\u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0633\u062c\u0644\u0629 \u0628\u062f\u0631\u0627\u0633\u0629 Napoli \u0641\u064a \u0627\u0644\u0639\u0631\u0627\u0642<sup>(16)<\/sup> \u0633\u0646\u0629 2013 \u0623\u0639\u0644\u0649 \u0648\u0628\u0644\u063a\u062a \u0627\u0644\u0646\u0633\u0628\u0629 86%. <\/span><span style=\"font-family: 'times new roman', times, serif;\">\u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0623\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0643\u0627\u0646\u062a \u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u062a\u0642\u062f\u0645\u0629 \u0645\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 (100\u066a)\u060c \u0645\u0639 \u0645\u0639\u062f\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0645\u0646\u062e\u0641\u0636 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u0644\u063a (52\u066a)\u060c \u062d\u064a\u062b 20\u066a \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0643\u0627\u0646\u0648\u0627 \u0645\u0642\u0627\u0648\u0645\u064a\u0646 \u0644\u0644\u0639\u0644\u0627\u062c\u060c \u064832\u066a \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u062d\u062f\u062b \u0644\u062f\u064a\u0647\u0645 \u0646\u0643\u0633. \u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0623\u0646 (51.4 \u066a) \u0645\u0646 \u0645\u0631\u0636\u0649 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0644\u0628\u064a\u0629 EBV \u0643\u0627\u0646\u0648\u0627 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u062d\u062f\u0648\u062f\u0629 \u0648\u062c\u0645\u064a\u0639 \u0645\u0631\u0636\u0649 \u0633\u0644\u0628\u064a\u064a EBV \u0643\u0627\u0646 \u0644\u062f\u064a\u0647\u0645 \u0645\u0639\u062f\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0645\u0631\u062a\u0641\u0639 \u0644\u0644\u0639\u0644\u0627\u062c (100 \u066a)\u060c \u062a\u0634\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0642\u064a\u0645\u0629 \u0625\u0646\u0630\u0627\u0631\u064a\u0629 \u0633\u064a\u0626\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 EBV \u0641\u064a \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646. \u0643\u0627\u0646\u062a \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0645\u062a\u0648\u0627\u0641\u0642\u0629 \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0629 Yin et el <sup>(17)<\/sup>\u0648 \u062f\u0631\u0627\u0633\u0629 \u00a0Kwon <sup>(18)<\/sup>\u0648\u062f\u0631\u0627\u0633\u0629 Koh <sup>(<\/sup><sup>19<\/sup><sup>)<\/sup>. \u0646\u0639\u062a\u0642\u062f \u0623\u0646 \u0648\u062c\u0648\u062f \u0641\u064a\u0631\u0648\u0633 EBV \u064a\u0632\u064a\u062f \u0645\u0646 \u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636 \u0648\u064a\u0639\u0637\u064a \u0625\u0646\u0630\u0627\u0631\u0627\u064b \u0633\u064a\u0626\u0627\u064b\u060c \u0644\u0623\u0646 \u0641\u064a\u0631\u0648\u0633 EBV \u064a\u0633\u0627\u0647\u0645 \u0641\u064a \u0627\u0644\u0628\u064a\u0626\u0629 \u0627\u0644\u0645\u0643\u0631\u0648\u064a\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u064a\u0637 \u0648\u062a\u062f\u0639\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0627\u0644\u0645\u0633\u0631\u0637\u0646 LMP1 \u0627\u0644\u0630\u064a \u064a\u062d\u0641\u0632 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0643\u064a\u0645\u0648\u0643\u064a\u0646\u0627\u062a\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 CCL5 (RANTES) \u0648CCL17 (TARC) \u0648interleukin-8 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 RS <sup>(20)<\/sup>\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0623\u0646 LMP1 \u064a\u0646\u0634\u0637 \u0633\u0628\u064a\u0644 \u0644\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0648\u0648\u064a NF-KB\u060c \u0648\u064a\u0646\u0634\u0637 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 1 ( AP-1)\u060c \u0648\u0648\u064a\u0642\u0644\u062f CD40 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 <sup>(21\u060c 22)<\/sup>\u060c \u0648\u064a\u062d\u062b \u0639\u0644\u0649 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 BCL2\u060c \u0643\u0644 \u0630\u0644\u0643 \u064a\u0632\u064a\u062f \u0645\u0646 \u0645\u0639\u062f\u0644 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 \u0648\u064a\u062b\u0628\u0637 \u0627\u0644\u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0648\u064a \u0627\u0644\u0645\u0628\u0631\u0645\u062c. <sup>(20)<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-562\" src=\"https:\/\/pharmjournal.asscph.com\/wp-content\/uploads\/2022\/01\/1-4-186x300.png\" alt=\"\" width=\"689\" height=\"1112\" \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a \u0648\u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u062a\u0648\u0636\u062d \u0648\u062a\u0624\u0643\u062f \u0646\u062a\u0627\u0626\u062c\u0646\u0627 \u0641\u064a\u0645\u0627 \u064a\u062e\u0635 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 EBV \u0628\u064a\u0646 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u062e\u0627\u0635\u0629 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\u0628\u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0645\u0627\u062b\u0644\u0629 \u0639\u0644\u0649 \u0623\u0648\u0631\u0627\u0645 \u0623\u062e\u0631\u0649 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0641\u064a\u0631\u0648\u0633 EBV\u060c \u0643\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0644\u0639\u0648\u0645 \u0627\u0644\u0623\u0646\u0641\u064a\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629 \u0648\u063a\u064a\u0631\u0647\u0627 \u0644\u062a\u0642\u0635\u064a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 EBV \u0641\u064a\u0647\u0627 \u0648\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0629.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction: \u064a\u0631\u062a\u0628\u0637 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u0628\u0634\u062a\u0627\u064a\u0646 \u0628\u0627\u0631 (EBV) Epstein-Barr Virus \u0628\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062e\u0628\u064a\u062b\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0644\u0645\u0641\u0648\u0645\u0629 \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0648\u0644\u0645\u0641\u0648\u0645\u0629 \u0628\u064a\u0631\u0643\u064a\u062a \u0648\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0644\u0639\u0648\u0645&#8230; <br \/><a href=\"https:\/\/pharmjournal.asscph.com\/?p=244\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":558,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-132","volume-8","year-137"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=244"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/244\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/558"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}