{"id":255,"date":"2021-10-01T19:40:31","date_gmt":"2021-10-01T19:40:31","guid":{"rendered":"https:\/\/pharmjournal.asscph.com\/?p=255"},"modified":"2024-07-21T17:04:01","modified_gmt":"2024-07-21T17:04:01","slug":"%d8%aa%d8%a3%d8%ab%d9%8a%d8%b1-%d8%a7%d9%84%d8%a8%d8%af%d8%a7%d9%86%d8%a9-%d9%81%d9%8a-%d8%a7%d9%84%d8%a8%d9%82%d9%8a%d8%a7-%d8%a7%d9%84%d9%83%d9%84%d9%8a%d9%91%d8%a9-%d9%84%d8%af%d9%89-%d9%85%d8%b1","status":"publish","type":"post","link":"https:\/\/pharmjournal.asscph.com\/?p=255","title":{"rendered":"\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0641\u064a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0646\u0642\u064a\u0644\u064a \u064a\u062e\u0636\u0639\u0646 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u062a\u0651\u0644\u0637\u064a\u0641\u064a\u0651\u0629: \u062f\u0631\u0627\u0633\u0629 \u062d\u0634\u062f\u064a\u0651\u0629 \u0627\u0633\u062a\u0628\u0627\u0642\u064a\u0651\u0629"},"content":{"rendered":"

\u0627\u0644<\/strong>\u0645\u0642\u062f\u0645\u0629 <\/strong>Introduction<\/strong><\/span><\/p>\n

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\u0627\u0644\u0646\u0651\u0633\u0627\u0621 \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u0627\u062a \u0628\u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0641\u064a \u0645\u0631\u0627\u062d\u0644 \u0645\u0628\u0643\u0651\u0631\u0629 \u064a\u0637\u0648\u0651\u0631\u0652\u0646 \u0646\u0642\u0627\u0626\u0644 \u0641\u064a \u0648\u0642\u062a\u064d \u0644\u0627\u062d\u0642 \u0645\u0646 \u0627\u0644\u062a\u0651\u0634\u062e\u064a\u0635 \u0648\u064a\u062f\u0639\u0649 \u0647\u0630\u0627 \u0627\u0644\u0646\u0651\u0645\u0637 \u0628\u0640 “\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0646\u0651\u0642\u064a\u0644\u064a \u0627\u0644\u062a\u0651\u0627\u0644\u064a \u0632\u0645\u0646\u064a\u0651\u0627\u064b \u0644\u0644\u062a\u0651\u0634\u062e\u064a\u0635”Metachronous\u00a0 Metastases Breast Cancer (MMBC) (1). <\/span>\u064a\u0639\u062f\u0651 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0646\u0651\u0642\u064a\u0644\u064a 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\u0645\u0646 \u0627\u0644\u0633\u0645\u0651\u0646\u0629 \u0627\u0644\u0645\u0641\u0631\u0637\u0629 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0645\u0639 \u0627\u0644\u0646\u0651\u0633\u0627\u0621 \u0627\u0644\u0646\u0651\u062d\u064a\u0644\u0627\u062a (\u0627\u0644\u0647\u0632\u064a\u0644\u0627\u062a)\u060c \u0627\u0644\u0623\u0645\u0631 \u0627\u0644\u0630\u064a \u064a\u0624\u062f\u0651\u064a \u0628\u062f\u0648\u0631\u0647 \u0625\u0644\u0649 \u0641\u0631\u0637 \u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0646\u0651\u0633\u062c \u0627\u0644\u0645\u062a\u062d\u0633\u0651\u0633\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0647\u0631\u0645\u0648\u0646 \u0648\u0639\u0644\u0649 \u0631\u0623\u0633\u0647\u0627 \u0627\u0644\u062b\u0651\u062f\u064a\u060c \u0648\u0628\u0627\u0644\u062a\u0651\u0627\u0644\u064a \u062a\u0639\u0632\u064a\u0632 \u0646\u0645\u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0648\u062a\u0637\u0648\u0651\u0631\u0647. \u0643\u0645\u0627 \u0642\u062f \u064a\u064f\u0639\u0632\u064e\u0649 \u0627\u0644\u062a\u0651\u0623\u062b\u064a\u0631 \u0627\u0644\u0645\u0646\u0633\u0648\u0628 \u0644\u0644\u0628\u062f\u0627\u0646\u0629 \u0641\u064a \u0632\u064a\u0627\u062f\u0629 \u0627\u062e\u062a\u0637\u0627\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0625\u0644\u0649 \u062a\u0623\u062b\u064a\u0631\u0627\u062a\u0647\u0627 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0625\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0651\u0645\u0648 \u0627\u0644\u0645\u0634\u0627\u0628\u0647 \u0644\u0644\u0625\u0646\u0633\u0648\u0644\u064a\u0646-1 Insulin-like Growth Factor-1 (IGF-1)\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a\u0647\u0627 \u0641\u064a \u062a\u0639\u062f\u064a\u0644 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0648\u0625\u0641\u0631\u0627\u0632\u0647\u0627 \u0645\u0646 \u0627\u0644\u0646\u0651\u0633\u062c \u0627\u0644\u0634\u0651\u062d\u0645\u064a\u0651\u0629 \u0648\u0627\u0644\u0628\u0627\u0644\u0639\u0627\u062a \u062d\u064a\u062b \u062a\u064f\u0639\u0631\u0651\u0641 \u0627\u0644\u0633\u0651\u0645\u0646\u0629 \u0628\u0643\u0648\u0646\u0647\u0627 \u062d\u0627\u0644\u0629 \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651\u0629 \u062a\u0633\u0628\u0628 \u062a\u062d\u0631\u0651\u0631 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0651\u0629 \u0627\u0644\u0645\u0639\u0632\u0651\u0632\u0629 \u0644\u0646\u0645\u0648 \u0627\u0644\u0648\u0631\u0651\u0645 \u0648\u062a\u0637\u0648\u0651\u0631\u0647 (9\u060c 10). \u0644\u0643\u0646 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0648\u0627\u0644\u0628\u0642\u064a\u0627 \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0646\u0651\u0642\u064a\u0644\u064a \u0644\u0627 \u062a\u0632\u0627\u0644 \u0645\u0628\u0647\u0645\u0629\u064b \u0648\u063a\u064a\u0631 \u0645\u062b\u0628\u062a\u0629 \u0623\u0648 \u0648\u0627\u0636\u062d\u0629 \u0627\u0644\u0637\u0651\u0628\u064a\u0639\u0629. \u0648\u0628\u0646\u0627\u0621\u064b \u0639\u0644\u064a\u0647\u060c \u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0625\u0644\u0649 \u062a\u062d\u0631\u0651\u064a \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0641\u064a \u0627\u0644\u0628\u0642\u064a\u0627 \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0646\u0642\u064a\u0644\u064a \u064a\u062e\u0636\u0639\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651 \u0627\u0644\u062a\u0651\u0644\u0637\u064a\u0641\u064a.<\/span><\/p>\n

\u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0642 <\/strong>Materials and Methods<\/strong><\/span><\/p>\n

\u0635\u064f\u0645\u0651\u0645\u062a \u0647\u0630\u0627 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0644\u062a\u0643\u0648\u0646 \u062f\u0631\u0627\u0633\u0629 \u062d\u0634\u062f\u064a\u0651\u0629 \u0627\u0633\u062a\u0628\u0627\u0642\u064a\u0651\u0629 Prospective Cohort Study \u0636\u0645\u0651\u062a \u062c\u0645\u0647\u0631\u0629 \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0651\u0642\u064a\u0644\u064a \u0627\u0644\u0644\u0627\u062a\u064a \u064a\u062a\u0644\u0642\u064a\u0646 \u0645\u0639\u0627\u0644\u062c\u0629 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u062a\u0644\u0651\u0637\u064a\u0641\u064a\u0651\u0629 \u0641\u064a \u0645\u0633\u062a\u0634\u0641\u0649 \u0627\u0644\u0628\u064a\u0631\u0648\u0646\u064a \u0627\u0644\u062c\u0627\u0645\u0639\u064a\u0651. \u062d\u0627\u0632\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u062c\u0646\u0629 \u0623\u062e\u0644\u0627\u0642\u064a\u0651\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0639\u0644\u0645\u064a\u0651 \u0641\u064a \u0643\u0644\u064a\u0629 \u0627\u0644\u0635\u0651\u064a\u062f\u0644\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u062f\u0645\u0634\u0642\u060c \u0648\u0623\u062c\u0631\u064a\u062a \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0651\u0629 \u0628\u064a\u0646 \u0646\u064a\u0633\u0627\u0646 2018 \u0625\u0644\u0649 \u0623\u064a\u0651\u0627\u0631 2020.<\/span><\/p>\n

\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0651\u0636\u0645\u064a\u0646 <\/strong>Inclusion Criteria<\/strong><\/span><\/p>\n

\u0634\u0645\u0644\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0651\u0636\u0645\u064a\u0646 \u0633\u064a\u0651\u062f\u0627\u062a\u064d \u0628\u0623\u0639\u0645\u0627\u0631\u064d \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 20 \u064880 \u0639\u0627\u0645\u0627\u064b \u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0646\u0642\u064a\u0644\u064a \u0648\u064a\u062e\u0636\u0639\u0646 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u062a\u0644\u0637\u064a\u0641\u064a\u0651\u0629 \u0643\u062e\u0637\u0651 \u0639\u0644\u0627\u062c\u064a\u0651 \u0623\u0648\u0651\u0644. \u0636\u0645\u0651\u062a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0634\u062e\u0651\u0635\u0627\u062a \u0628\u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a\u0651 \u0646\u0642\u064a\u0644\u064a\u0651 \u0645\u0646 \u0643\u0644\u0627 \u0627\u0644\u0646\u0651\u0645\u0637\u064a\u0646 SMBC \u0648MMBC \u0628\u062c\u0645\u064a\u0639 \u0623\u0646\u0645\u0627\u0637\u0647\u0645\u0627 \u0627\u0644\u0638\u0627\u0647\u0631\u064a\u0651\u0629. \u0634\u0645\u0644\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062e\u0627\u0636\u0639\u0627\u062a \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0634\u0651\u0639\u0627\u0639\u064a\u0651\u0629 \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0646\u0651\u0642\u0627\u0626\u0644 \u0627\u0644\u062f\u0651\u0645\u0627\u063a\u064a\u0651\u0629 \u0648\u0627\u0644\u0644\u0648\u0627\u062a\u064a \u064a\u062a\u0644\u0642\u064a\u0646 Zoledronic Acid \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0646\u0642\u0627\u0626\u0644 \u0627\u0644\u0639\u0638\u0645\u064a\u0651\u0629.<\/span><\/p>\n

\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0625\u0642\u0635\u0627\u0621\/\u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f <\/strong>Exclusion Criteria<\/strong><\/span><\/p>\n

\u0627\u0633\u062a\u064f\u0628\u0639\u0650\u062f\u064e\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0648\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0628\u062d\u0627\u0644\u0629 \u0639\u0627\u0645\u0651\u0629 \u0633\u064a\u0626\u0629\/\u0645\u062a\u062f\u0646\u064a\u0651\u0629 (\u02c22 \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0639\u0627\u064a\u064a\u0631 (ECOG) Eastern Cooperative Oncology Group). \u0643\u0645\u0627 \u0644\u0645 \u062a\u0634\u0645\u064f\u0644 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u063a\u064a\u0631 \u0627\u0644\u0642\u0627\u062f\u0631\u0627\u062a \u0639\u0644\u0649 \u062a\u062d\u0645\u0651\u0644 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0643\u064a\u0645\u0627\u0626\u064a\u0651\u0629 \u0646\u062a\u064a\u062c\u0629\u064b \u0644\u0641\u0634\u0644\u064d \u0643\u0644\u0648\u064a\u0651 \u0623\u0648 \u0644\u0627\u0646\u062e\u0641\u0627\u0636 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0627\u0646\u0642\u0628\u0627\u0636\u064a\u0629 (Ejection Fraction \u226440%)\u060c \u0648\u0643\u0630\u0644\u0643 \u0641\u064a \u062d\u0627\u0644 \u062e\u0636\u0648\u0639 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629 \u062a\u0644\u0637\u064a\u0641\u064a\u0651\u0629. \u0643\u0645\u0627 \u0627\u0633\u062a\u064f\u0628\u0639\u062f\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u064f\u0646\u0642\u0637\u0639\u0627\u062a \u0639\u0646 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0646\u062a\u064a\u062c\u0629\u064b \u0644\u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062f\u0648\u0627\u0621 \u0623\u0648 \u0644\u0623\u064a\u0651 \u0633\u0628\u0628 \u0622\u062e\u0631. <\/span>\u0633\u064f\u062c\u0651\u0644 \u0648\u0632\u0646 (\u0643\u063a) \u0643\u0644 \u0645\u0631\u064a\u0636\u0629 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u064a\u0632\u0627\u0646 \u0631\u0642\u0645\u064a \u0645\u0639 \u0627\u0644\u062a\u0642\u0631\u064a\u0628 \u0627\u0644\u0649 \u0623\u0642\u0631\u0628 0.1 \u0643\u063a \u0648\u0637\u0648\u0644\u0647\u0627 (\u0645\u062a\u0631) \u0645\u0639 \u0627\u0644\u062a\u0642\u0631\u064a\u0628 \u0625\u0644\u0649 \u0623\u0642\u0631\u0628 0.1 \u0633\u0645\u060c \u062b\u0645 \u062d\u064f\u0633\u0628 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 Body Mass Index (BMI) \u0639\u0644\u0649 \u0627\u0644\u0646\u0651\u062d\u0648 \u0627\u0644\u062a\u0627\u0644\u064a { BMI= \u0627\u0644\u0648\u0632\u0646 (\u0643\u063a)\/ \u0645\u0631\u0628\u0651\u0639 \u0627\u0644\u0637\u0648\u0644 (\u06452<\/sup>)}\u060c \u0648\u0635\u064f\u0646\u0641\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u062a\u0628\u0639\u0627\u064b \u0644\u062a\u0635\u0646\u064a\u0641\u0627\u062a \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u0651\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0651\u0629 (WHO) \u0625\u0644\u0649 \u0645\u0646\u062e\u0641\u0636\u0627\u062a \u0627\u0644\u0648\u0632\u0646 (BMI <18.5 \u0643\u063a\/\u06452<\/sup>) \u0648\u0633\u0648\u064a\u0651\u0627\u062a \u0627\u0644\u0648\u0632\u0646 (BMI = 18.5\u201324.9 \u0643\u063a\/\u06452<\/sup>) \u0648\u0645\u0641\u0631\u0637\u0627\u062a \u0627\u0644\u0648\u0632\u0646 (BMI=25\u201329.9 \u0643\u063a\/\u06452<\/sup>) \u0648\u0628\u062f\u064a\u0646\u0627\u062a ( BMI\u2265 30 \u0643\u063a\/\u06452<\/sup>). <\/span>\u0639\u064f\u0628\u0651\u0631 \u0639\u0646 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0627\u0644\u0645\u0631\u0643\u0632\u064a\u0629Central Obesity (CO) \u00a0\u0628\u0643\u0644\u0651\u064d \u0645\u0646 \u0627\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u062a\u0627\u062a \u0627\u0644\u062a\u0651\u0627\u0644\u064a\u0629\u061b \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631Waist circumference (WC)\u060c \u0648\u0645\u062d\u064a\u0637 \u0627\u0644\u0648\u0631\u0643Hip circumference (HC)\u060c \u0648\u0646\u0633\u0628\u0629 \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0625\u0644\u0649 \u0645\u062d\u064a\u0637 \u0627\u0644\u0648\u0631\u0643 Waist-to-hip-ratio (WHR). \u0642\u064a\u0633 \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 (WC) (\u0633\u0645) \u0644\u0643\u0644 \u0645\u0631\u064a\u0636\u0629 \u0641\u064a \u0648\u0636\u0639\u064a\u0651\u0629 \u0627\u0644\u0648\u0642\u0648\u0641 \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0627\u0632\u0648\u0631\u0629 \u0627\u0644\u062e\u064a\u0627\u0637\u0629 \u0645\u0648\u0636\u0648\u0639\u0629\u064b \u0628\u0634\u0643\u0644 \u0623\u0641\u0642\u064a\u0651 \u0645\u0648\u0627\u0632\u064d \u0644\u0644\u0623\u0631\u0636 \u0641\u064a \u0623\u0636\u064a\u0642 \u0645\u0646\u0637\u0642\u0629 \u0628\u064a\u0646 \u0622\u062e\u0631 \u0636\u0644\u0639 \u0645\u062c\u0633\u0648\u0633 \u0648\u0642\u0645\u0629 \u0627\u0644\u062d\u0631\u0642\u0641\u0629\u060c \u0648\u0635\u064f\u0646\u0651\u0641\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0651\u0629 (WHO) \u0625\u0644\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0645\u062d\u064a\u0637 \u062e\u0635\u0631 \u0646\u062d\u064a\u0644 (\u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u226480 \u0633\u0645) \u0648\u0645\u0631\u064a\u0636\u0627\u062a \u0628\u0645\u062d\u064a\u0637 \u062e\u0635\u0631 \u0643\u0628\u064a\u0631 (\u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u02c280 \u0633\u0645). \u0643\u0645\u0627 \u0642\u064a\u0633 \u0645\u062d\u064a\u0637 \u0627\u0644\u0648\u0631\u0643 (HC) (\u0633\u0645) \u0628\u062a\u0633\u062c\u064a\u0644 \u0623\u0643\u0628\u0631 \u0642\u064a\u0645\u0629 \u0644\u0645\u062d\u064a\u0637 \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0623\u0631\u062f\u0627\u0641 \u0628\u0648\u0636\u0639\u064a\u0629 \u0627\u0644\u0648\u0642\u0648\u0641. \u062d\u064f\u0633\u0628\u062a \u0646\u0633\u0628\u0629 \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0625\u0644\u0649 \u0645\u062d\u064a\u0637 \u0627\u0644\u0648\u0631\u0643 (WHR) \u0643\u0645\u0627 \u064a\u0644\u064a WHR} = \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 (\u0633\u0645)\/ \u0645\u062d\u064a\u0637 \u0627\u0644\u0648\u0631\u0643 (\u0633\u0645){\u060c \u0648\u0635\u064f\u0646\u0641\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0651\u0629 (WHO) \u0628\u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u0642\u064a\u0645\u0629 \u062d\u062f\u064a\u0651\u0629 Cut off=0.85)) \u0625\u0644\u0649 \u0645\u0631\u064a\u0636\u0627\u062a\u064d \u0630\u0648\u0627\u062a \u0646\u0633\u0628\u0629 \u0645\u0646\u062e\u0641\u0636\u0629 <0.85\u060c \u0648\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0646\u0633\u0628\u0629 \u0645\u0631\u062a\u0641\u0639\u0629 \u22650.85. <\/span>\u0643\u0645\u0627 \u062d\u064f\u0633\u0628\u062a \u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u0629 \u0644\u062f\u0647\u0648\u0646 \u0627\u0644\u062c\u0633\u0645 Body Fat Percentage (BF%) \u0627\u0633\u062a\u0646\u0627\u062f\u0627\u064b \u0625\u0644\u0649 \u0645\u0639\u0627\u062f\u0644\u0629 \u062f\u064a\u0648\u0631\u0646\u0628\u0631\u063a Deurenberg\u2019s Equation\u060c }\u062f\u0647\u0648\u0646 \u0627\u0644\u062c\u0633\u0645 (%)= (1.20 \u00a0x\u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (\u0643\u063a\/\u06452<\/sup>)) + (0.23 x \u0627\u0644\u0639\u0645\u0631(\u0623\u0639\u0648\u0627\u0645)) \u2013 (10.8 x \u0627\u0644\u062c\u0646\u0633) \u00a0-5.4{\u060c (\u062d\u064a\u062b \u062a\u064f\u0639\u0637\u0649 \u0627\u0644\u0642\u064a\u0645\u0629 1 \u0644\u0644\u0631\u062c\u0627\u0644 \u0648\u0627\u0644\u0642\u064a\u0645\u0629 0 \u0644\u0644\u0646\u0633\u0627\u0621). \u062b\u0645\u0651 \u0635\u064f\u0646\u0651\u0641\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u062a\u0628\u0639\u0627\u064b \u0644\u062a\u0635\u0646\u064a\u0641\u0627\u062a \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 ((WHO \u0628\u0627\u0639\u062a\u0645\u0627\u062f \u0642\u064a\u0645\u0629 \u062d\u062f\u064a\u0651\u0629 \u0642\u062f\u0631\u064f\u0647\u0627 35% \u0625\u0644\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646\u062e\u0641\u0636\u0627\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u062f\u0651\u0647\u0648\u0646 )FB% <35%) \u0648\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0627\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u062f\u0651\u0647\u0648\u0646 (FB% \u226535%) (11).<\/span><\/p>\n

\u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a\/ \u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0651\u0647\u0627\u064a\u0629 \u0648\u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 <\/strong>Outcomes\/End Points and Statistical Analyses<\/strong><\/span><\/p>\n

\u0627\u0639\u062a\u064f\u0645\u062f\u062a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 Overall Survival (OS) \u0643\u0646\u0642\u0637\u0629 \u0646\u0647\u0627\u064a\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627\u060c \u0648\u0639\u0631\u0651\u0641\u062a \u0628\u0643\u0648\u0646\u0647\u0627 \u0627\u0644\u0641\u062a\u0631\u0629 \u0627\u0644\u0632\u0645\u0646\u064a\u0651\u0629 \u0627\u0644\u0645\u0645\u062a\u062f\u0651\u0629 \u0645\u0646\u0630 \u062a\u0634\u062e\u064a\u0635 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u0625\u0644\u0649 \u062d\u0635\u0648\u0644 \u0627\u0644\u0648\u0641\u0627\u0629 \u0644\u0623\u064a\u0651 \u0633\u0628\u0628\u064d \u0643\u0627\u0646. \u0648\u064f\u0635\u0650\u0641 \u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 survival rate overall \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u0639\u0644\u0649 \u0623\u0646\u0651\u0647 \u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u0629 \u0644\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0644\u0651\u0648\u0627\u062a\u064a \u0628\u0642\u064a\u0652\u0646 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0644\u0645\u062f\u0651\u0629 18 \u0634\u0647\u0631\u0627\u064b \u0648\u0630\u0644\u0643 \u0645\u0646\u0630 \u062a\u0627\u0631\u064a\u062e \u0627\u0644\u062a\u0634\u062e\u064a\u0635. <\/span>\u062d\u064f\u0644\u0644\u062a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a SPSS\u00ae (Statistical Package for Social Science) \u0628\u0625\u0635\u062f\u0627\u0631\u0647 \u0627\u0644\u062b\u0627\u0644\u062b \u0648\u0627\u0644\u0639\u0634\u0631\u064a\u0646 \u0648\u0628\u0631\u0645\u062c\u064a\u0651\u0629 GraphPad Prism\u00ae \u0628\u0625\u0635\u062f\u0627\u0631\u0647\u0627 \u0627\u0644\u062b\u0651\u0627\u0645\u0646\u060c \u062d\u064a\u062b \u0623\u064f\u062c\u0631\u064a \u0627\u0644\u062a\u0651\u062d\u0644\u064a\u0644 \u0627\u0644\u0648\u0635\u0641\u064a\u0651 \u0648\u0642\u064a\u0651\u0645 \u0646\u0648\u0639 \u0627\u0644\u062a\u0648\u0632\u0651\u0639 \u0644\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0643\u0645\u064a\u0651\u0629 \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0651\u0629 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u062e\u062a\u0628\u0627\u0631 Kolmogorov-Smirnov\u060c \u0639\u064f\u0628\u0651\u0650\u0631 \u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0651\u0631\u0627\u062a \u0627\u0644\u0643\u0645\u064a\u0651\u0629 \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0651\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u0628\u0639 \u062a\u0648\u0632\u0639\u0627\u064b \u0637\u0628\u064a\u0639\u064a\u0651\u0627\u064b \u0628\u0627\u0644\u0645\u062a\u0648\u0633\u0651\u0637 \u0648\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a \u0628\u064a\u0646\u0645\u0627 \u0627\u0633\u062a\u064f\u0639\u0645\u0650\u0644 \u0627\u0644\u0648\u0633\u064a\u0637 \u0648\u0627\u0644\u0645\u062f\u0649 \u0644\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0643\u0645\u064a\u0651\u0629 \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0651\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u0628\u0639 \u062a\u0648\u0632\u0639\u0627\u064b \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a\u0651. \u0643\u0645\u0627 \u0639\u064f\u0628\u0651\u0650\u0631 \u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0627\u0633\u0645\u064a\u0651\u0629 \u0648\u0627\u0644\u0641\u0626\u0648\u064a\u0651\u0629 \u0628\u0627\u0644\u062a\u0651\u0648\u0627\u062a\u0631 \u0648\u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u0629. <\/span>\u0627\u0633\u062a\u064f\u0639\u0645\u0644\u062a \u0637\u0631\u064a\u0642\u0629 \u0643\u0627\u0628\u0644\u0646 \u0645\u0627\u064a\u0631 Kaplan-Meier \u0644\u062d\u0633\u0627\u0628 \u0648\u0633\u064a\u0637 \u0648\u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0628\u0642\u064a\u0627 OS\u060c \u0648\u0642\u064f\u064a\u0651\u0645 \u0648\u062c\u0648\u062f \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u062e\u062a\u0628\u0627\u0631 Log-rank. \u0643\u0645\u0627 \u062d\u064f\u062f\u0651\u062f\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 Hazard Ratios (HRs) \u0645\u0639 95% \u0641\u0648\u0627\u0635\u0644 \u0645\u0648\u062b\u0648\u0642\u064a\u0651\u0629 (CIs) Confidence Intervals. \u0627\u0639\u062a\u064f\u0645\u062f\u062a \u0642\u064a\u0645\u0629 \u0627\u0644\u062f\u0651\u0644\u0627\u0644\u0629 P<0.05 \u0643\u0642\u064a\u0645\u0629 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u0645\u0637\u0628\u0651\u0642\u0629.<\/span><\/p>\n

\u0627\u0644\u0646\u0651\u062a\u0627\u0626\u062c <\/strong>Results<\/strong><\/span><\/p>\n

\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u0651\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629<\/strong><\/span><\/p>\n

\u062a\u0636\u0645\u0651\u0646\u062a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 156 \u0645\u0631\u064a\u0636\u0629 \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0646\u0642\u064a\u0644\u064a\u0651 \u064a\u062e\u0636\u0639\u0646 \u0644\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0629 \u0627\u0644\u062a\u0644\u0637\u064a\u0641\u064a\u0651\u0629 \u0643\u062e\u0637\u064d\u0651 \u0623\u0648\u0651\u0644 \u0648\u0645\u062d\u0642\u0651\u0642\u0627\u062a \u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0651\u0636\u0645\u064a\u0646. \u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u0634\u0651\u0643\u0644 1\u060c \u0645\u062e\u0637\u0651\u0637\u0627\u064b \u0627\u0646\u0633\u064a\u0627\u0628\u064a\u0651\u0627\u064b \u062a\u0641\u0635\u064a\u0644\u064a\u0651\u0627\u064b \u0644\u0645\u062c\u0631\u064a\u0627\u062a \u0627\u0646\u062a\u0642\u0627\u0621 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u0643\u0645\u0627 \u064a\u0648\u0636\u0651\u062d \u0627\u0644\u062c\u062f\u0648\u0644 1\u060c \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u0651\u064a\u0645\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629. <\/span>\u062a\u0631\u0627\u0648\u062d\u062a \u0623\u0639\u0645\u0627\u0631 \u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062c\u0645\u0647\u0631\u0629 \u0628\u064a\u0646 24-80 \u0639\u0627\u0645\u0627\u064b\u060c \u0648\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0651\u0637 \u0627\u0644\u0639\u0645\u0631 (\u00b1\u0627\u0644\u0627\u0646\u062d\u0631\u0627\u0641 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u064a) 48.89 (\u00b19.96) \u0639\u0627\u0645\u0627\u064b. \u062a\u062c\u0627\u0648\u0632\u062a \u0646\u0633\u0628\u0629 48.1% \u0645\u0646 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0646\u062e\u0631\u0637\u0627\u062a \u0641\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0633\u0646\u0651 \u0627\u0644\u0625\u064a\u0627\u0633. \u062a\u0648\u0632\u0639\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0628\u064a\u0646 74 (47.4%) \u0645\u0631\u064a\u0636\u0629 \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0646\u0642\u064a\u0644\u064a \u0645\u0648\u0627\u0642\u062a \u0632\u0645\u0646\u064a\u0651\u0627\u064b \u0644\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0623\u0648\u0651\u0644\u064a (SMBC) \u064882 (52.6%) \u0645\u0631\u064a\u0636\u0629 \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0646\u0642\u064a\u0644\u064a \u062a\u0627\u0644\u064a \u0632\u0645\u0646\u064a\u0651\u0627\u064b \u0644\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0623\u0648\u0651\u0644\u064a (MMBC). <\/span>\u062f\u064f\u0631\u0633 \u062a\u0648\u0632\u0639 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u062a\u0628\u0639\u0627\u064b \u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0651\u0629 \u0644\u0644\u0648\u0631\u0645 \u0627\u0644\u0628\u062f\u0626\u064a\u0651. \u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0651\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER+) Estrogen Receptor 55.8%\u060c \u0641\u064a \u062d\u064a\u0646 \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0623\u0648\u0631\u0627\u0645\u064d \u0625\u064a\u062c\u0627\u0628\u064a\u0651\u0629 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0628\u0631\u0648\u062c\u064a\u0633\u062a\u064a\u0631\u0648\u0646 Progesterone Receptor (PR+) 57.7%. \u0648\u0644\u0645 \u062a\u062a\u062c\u0627\u0648\u0632 \u0646\u0633\u0628\u0629 \u0625\u064a\u062c\u0627\u0628\u064a\u0651\u0629 \u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0651\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0648\u064a\u0651 \u0627\u0644\u0628\u0634\u0631\u064a\u0651Human Epidermal Growth Factor Receptor-2 (HER-2) \u0627\u0644\u0640 27.6% \u0645\u0646 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629. \u0643\u0645\u0627 \u062f\u064f\u0631\u0633 \u062a\u0648\u0632\u0651\u0639 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u062a\u0628\u0639\u0627\u064b \u0644\u0623\u0645\u0627\u0643\u0646 \u062a\u0648\u0636\u0651\u0639 \u0627\u0644\u0646\u0642\u0627\u0626\u0644 \u0648\u0639\u062f\u062f \u0645\u0642\u0631\u0651\u0627\u062a\u0647\u0627 \u062d\u064a\u062b \u062a\u0635\u062f\u0651\u0631\u062a \u0627\u0644\u0646\u0642\u0627\u0626\u0644 \u0627\u0644\u0639\u0638\u0645\u064a\u0651\u0629 \u062c\u0645\u0647\u0631\u0629 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u0651\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 1.<\/span><\/p>\n

\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0628\u062f\u0627\u0646\u0629<\/strong><\/span><\/p>\n

\u062f\u064f\u0631\u0633\u062a \u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0644\u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0648\u0627\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u062a\u064a \u0634\u0645\u0644\u062a \u0643\u0644\u0651\u0627\u064b \u0645\u0646 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 BMI\u060c \u0648\u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 WC\u060c \u0648\u0646\u0633\u0628\u0629 \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0625\u0644\u0649 \u0645\u062d\u064a\u0637 \u0627\u0644\u0648\u0631\u0643 WHR\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u0629 \u0644\u062f\u0647\u0648\u0646 \u0627\u0644\u062c\u0633\u0645 BF%\u060c \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u0651\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 2. <\/span>\u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (BMI) \u0644\u0643\u0627\u0645\u0644 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 28.6 \u0643\u063a\/ \u06452<\/sup> \u0648\u062a\u0631\u0627\u0648\u062d \u0645\u062c\u0627\u0644\u0647 \u0628\u064a\u0646 (16.2\u201353.6) \u0643\u063a\/ \u06452<\/sup>. \u0643\u0627\u0646\u062a \u063a\u0627\u0644\u0628\u064a\u0651\u0629 \u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 (73.7%) \u0645\u0641\u0631\u0637\u0627\u062a \u0627\u0644\u0648\u0632\u0646 overweight \u0648\u0628\u062f\u064a\u0646\u0627\u062aobese \u060c \u0641\u064a \u062d\u064a\u0646 \u0634\u0643\u0651\u0644\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0648\u064a\u0651\u0627\u062a \u0627\u0644\u0648\u0632\u0646 normal weight \u0648\u0645\u0646\u062e\u0641\u0636\u0627\u062a \u00a0\u0627\u0644\u0648\u0632\u0646 underweight \u0645\u0627 \u0646\u0633\u0628\u062a\u0647 26.3% \u0645\u0646 \u0645\u062c\u0645\u0644 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a. <\/span>\u062a\u062c\u0627\u0648\u0632\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 >80 \u0633\u0645 \u062b\u0644\u0627\u062b\u0629 \u0623\u0631\u0628\u0627\u0639 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0646\u0633\u0628\u0629\u064d \u0628\u0644\u063a\u062a (78.9%)\u060c \u0643\u0645\u0627 \u062a\u062c\u0627\u0648\u0632\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0646\u0633\u0628\u0629 \u0645\u062d\u064a\u0637 \u062e\u0635\u0631 \u0625\u0644\u0649 \u0645\u062d\u064a\u0637 \u0648\u0631\u0643 \u22650.85 \u0627\u0644\u0646\u0651\u0635\u0641 \u0628\u0646\u0633\u0628\u0629\u064d \u0642\u062f\u0631\u064f\u0647\u0627 51%. \u0648\u0634\u0643\u0651\u0644\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0651\u0629 \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0644\u062f\u0647\u0648\u0646 \u0627\u0644\u062c\u0633\u0645 \u226535% \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 \u062b\u0644\u0627\u062b\u0629 \u0623\u0631\u0628\u0627\u0639 \u062c\u0645\u0647\u0631\u0629 \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0628\u0646\u0633\u0628\u0629\u064d \u0642\u062f\u0631\u064f\u0647\u0627 76.9%.<\/span><\/p>\n

\"\"<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0641\u064a \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 <\/strong>Overall Survival<\/strong> (<\/strong>OS<\/strong>)<\/strong><\/span><\/p>\n

\u0642\u0645\u0646\u0627 \u0628\u062a\u0642\u0635\u064a \u0627\u0644\u0623\u0647\u0645\u064a\u0651\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0644\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u062a\u0627\u062a \u0627\u0644\u0645\u062a\u0636\u0645\u0651\u0646\u0629 \u0641\u064a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0642\u064a\u0627 \u0648\u0630\u0644\u0643 \u0628\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 (OS) \u0644\u062f\u0649 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0635\u0646\u0651\u0641\u0627\u062a \u0648\u0641\u0642\u0627\u064b \u0644\u0641\u0626\u0627\u062a \u0643\u0644 \u0645\u062a\u062b\u0627\u0628\u062a \u062e\u0644\u0627\u0644 \u0641\u062a\u0631\u0629 \u0645\u062a\u0627\u0628\u0639\u0629 \u062f\u0627\u0645\u062a 18 \u0634\u0647\u0631\u0627\u064b. \u064a\u0644\u062e\u0651\u0635 \u0627\u0644\u062c\u062f\u0648\u0644 3\u060c \u0627\u0644\u0623\u0647\u0645\u064a\u0651\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0644\u0645\u062a\u062b\u0627\u0628\u062a\u062a\u0627\u062a \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629 \u0648\u0627\u0644\u0645\u0639\u0628\u0651\u0631 \u0639\u0646\u0647\u0627 \u0628\u0646\u0633\u0628 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 HRs \u0639\u0644\u0649 \u0627\u0644\u0628\u0642\u064a\u0627. \u0628\u0644\u063a \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 18 \u0634\u0647\u0631\u0627\u064b (\u0627\u0644\u0645\u062f\u0649\u060c2\u201318) \u0644\u062f\u0649 \u0643\u0627\u0645\u0644 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0629\u060c \u0648\u0642\u062f \u0633\u064f\u062c\u0651\u0644\u062a 33 \u062d\u0627\u0644\u0629 \u0648\u0641\u0627\u0629 \u0628\u0646\u0633\u0628\u0629\u064d \u0648\u0635\u0644\u062a \u0625\u0644\u0649 21.2%. <\/span>\u062a\u0631\u0627\u0641\u0642 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0645\u0631\u062a\u0641\u0639 (BMI \u226525 \u0643\u063a\/\u06452<\/sup>) \u0645\u0639 \u0627\u0646\u062e\u0641\u0627\u0636\u064d \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0641\u064a \u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0628\u0646\u0633\u0628\u0629\u064d \u0642\u0627\u0631\u0628\u062a \u0627\u0644\u062b\u0651\u0644\u062b\u064a\u0646 (HR=0.357\u060c P=0.003). \u062a\u062c\u0627\u0648\u0632 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 18 \u0634\u0647\u0631\u0627\u064b \u0648\u0648\u0635\u0644 \u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0628\u0642\u064a\u0627 \u0625\u0644\u0649 85.1% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0627\u062a \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (BMI \u226525 \u0643\u063a\/\u06452<\/sup>)\u061b \u0643\u0645\u0627 \u062a\u062c\u0627\u0648\u0632 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 18 \u0634\u0647\u0631\u0627\u064b \u0628\u064a\u0646\u0645\u0627 \u0644\u0645 \u064a\u062a\u0639\u062f\u0651 \u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0628\u0642\u064a\u0627 60.7% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646\u062e\u0641\u0636\u0627\u062a \u0648\u0633\u0648\u064a\u0651\u0627\u062a \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 (BMI >25 \u0643\u063a\/\u06452<\/sup>)\u060c \u0648\u0628\u0641\u0627\u0631\u0642\u064d \u064a\u0639\u062a\u062f\u0651 \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P=0.002). \u0627\u0644\u0634\u0651\u0643\u0644 2\u060c A. \u062f\u064f\u0631\u0650\u0633 \u062a\u0623\u062b\u064a\u0631 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 \u0639\u0644\u0649 \u0627\u0644\u0628\u0642\u064a\u0627 \u0628\u0635\u0648\u0631\u0629 \u0623\u0643\u062b\u0631 \u0645\u064a\u0632\u0627\u064b \u0644\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0641\u0631\u0639\u064a\u0651\u0629\u060c \u062a\u0634\u0627\u0631\u0643\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646\u062e\u0641\u0636\u0627\u062a \u0648\u0633\u0648\u064a\u0651\u0627\u062a \u0627\u0644\u0648\u0632\u0646 (IBM >25 \u0643\u063a\/\u06452<\/sup>) \u0648\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0641\u0631\u0637\u0627\u062a \u0627\u0644\u0648\u0632\u0646 \u0648\u0627\u0644\u0628\u062f\u064a\u0646\u0627\u062a \u0648\u0633\u064a\u0637 \u0628\u0642\u064a\u0627 \u062a\u062c\u0627\u0648\u0632 18 \u0634\u0647\u0631\u0627\u064b\u060c \u0645\u0639 \u0623\u0639\u0644\u0649 \u0645\u0639\u062f\u0651\u0644 \u0628\u0642\u064a\u0627 \u0628\u0644\u063a 88.6% \u0644\u062f\u0649 \u0645\u0641\u0631\u0637\u0627\u062a \u0627\u0644\u0648\u0632\u0646 \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0645\u0639\u062f\u0651\u0644 OS \u0642\u062f\u064f\u0631\u0647 60.7% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646\u062e\u0641\u0636\u0627\u062a \u0648\u0633\u0648\u064a\u0627\u062a \u0627\u0644\u0648\u0632\u0646 (IBM >25 \u0643\u063a\/\u06452<\/sup>) \u064882% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0628\u062f\u064a\u0646\u0627\u062a\u060c \u0648\u0628\u0644\u063a\u062a \u0642\u064a\u0645\u0629 \u0627\u0644\u062f\u0651\u0644\u0627\u0644\u0629 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 0.006=P. \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u0651\u062a\u0627\u0626\u062c \u0628\u0642\u064a\u0627 \u0623\u0641\u0636\u0644 \u0644\u0635\u0627\u0644\u062d \u0643\u0644\u0651\u064d \u0645\u0646 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0641\u0631\u0637\u0627\u062a \u0627\u0644\u0648\u0632\u0646 \u0648\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0628\u062f\u064a\u0646\u0627\u062a \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0628\u0642\u064a\u0627 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646\u062e\u0641\u0636\u0627\u062a \u0648\u0633\u0648\u064a\u0651\u0627\u062a \u0627\u0644\u0648\u0632\u0646 (IBM >25 \u0643\u063a\/\u06452<\/sup>)\u060c \u0648\u0628\u0641\u0648\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651 \u0628\u0647\u0627 \u0625\u062d\u0635\u0627\u0626\u064a\u0651\u0627\u064b (P=0.003 \u0648P=0.027\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0651\u0631\u062a\u064a\u0628). \u0627\u0644\u0634\u0651\u0643\u0644 2\u060c B. <\/span>\u0643\u0645\u0627 \u062a\u0631\u0627\u0641\u0642 \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0627\u0644\u0645\u0631\u062a\u0641\u0639 (WC >80 \u0633\u0645) \u0645\u0639 \u0627\u0646\u062e\u0641\u0627\u0636\u064d \u0645\u0639\u062a\u062f\u0651 \u0628\u0647 \u0641\u064a \u0645\u0639\u062f\u0644 \u0627\u0644\u0648\u0641\u064a\u0651\u0627\u062a \u0628\u0646\u0633\u0628\u0629 \u0642\u0627\u0631\u0628\u062a \u0627\u0644\u062b\u0651\u0644\u062b\u064a\u0646 (HR=0.392\u060c P=0.011). \u062d\u064a\u062b \u062a\u062c\u0627\u0648\u0632 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0627\u0644\u0645\u0631\u062a\u0641\u0639 18 \u0634\u0647\u0631\u0627\u064b \u0648\u0645\u0639\u062f\u0651\u0644 \u0644\u0644\u0628\u0642\u064a\u0627 \u0642\u062f\u0631\u0647 83.5%\u060c \u0643\u0645\u0627 \u062a\u062c\u0627\u0648\u0632 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 18 \u0634\u0647\u0631\u0627\u064b \u0648\u0644\u0645 \u064a\u062a\u0639\u062f\u0651 \u0645\u0639\u062f\u0651\u0644\u0647\u0627 61% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u060c \u0648\u0643\u0627\u0646 \u0627\u0644\u0641\u0627\u0631\u0642 \u0628\u064a\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0645\u0639\u062a\u062f\u0651\u0627\u064b \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b \u0648\u0628\u0642\u064a\u0645\u0629 \u062f\u0644\u0627\u0644\u0629 \u0628\u0644\u063a\u062a P=0.008. \u0627\u0644\u0634\u0651\u0643\u0644 2\u060c C. <\/span>\u0648\u0639\u0644\u0649 \u0646\u062d\u0648\u064d \u0645\u0645\u0627\u062b\u0644\u060c \u062a\u0631\u0627\u0641\u0642\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u062f\u0651\u0647\u0648\u0646 \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 (FB% \u226535%) \u0645\u0639 \u0627\u0646\u062e\u0641\u0627\u0636\u064d \u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0628\u0646\u0633\u0628\u0629 \u0642\u0627\u0631\u0628\u062a \u0627\u0644\u062b\u0644\u062b\u064a\u0646 \u0623\u064a\u0636\u0627\u064b (HR=0.376\u060c P=0.006)\u060c \u062d\u064a\u062b \u062a\u062c\u0627\u0648\u0632 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 18 \u0634\u0647\u0631\u0627\u064b \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0627\u062a \u0646\u0633\u0628\u0629 \u062f\u0647\u0648\u0646 \u0627\u0644\u062c\u0633\u0645 \u0648\u0645\u0646\u062e\u0641\u0636\u0627\u062a\u0647\u0627\u060c \u0645\u0639 \u0627\u062e\u062a\u0644\u0627\u0641\u064d \u0641\u064a \u0645\u0639\u062f\u0651\u0644 \u0627\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0630\u064a \u0644\u0645 \u064a\u062a\u062c\u0627\u0648\u0632 60.9% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0646\u062e\u0641\u0636\u0627\u062a \u0627\u0644\u0646\u0651\u0633\u0628\u0629\u060c \u0641\u064a \u062d\u064a\u0646 \u0648\u0635\u0644 \u0625\u0644\u0649 84% \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0627\u062a \u0627\u0644\u0646\u0651\u0633\u0628\u0629 \u0648\u0628\u0641\u0627\u0631\u0642 \u0645\u0639\u062a\u062f\u0651\u064d \u0628\u0647 \u0625\u062d\u0635\u0627\u0626\u064a\u0627\u064b (P=0.004). \u0627\u0644\u0634\u0651\u0643\u0644 2\u060c D. <\/span>\u0623\u0645\u0651\u0627 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0625\u0644\u0649 \u0645\u062d\u064a\u0637 \u0627\u0644\u0648\u0631\u0643\u061b \u0641\u0642\u062f \u062a\u062c\u0627\u0648\u0632 \u0648\u0633\u064a\u0637 \u0627\u0644\u0628\u0642\u064a\u0627 18 \u0634\u0647\u0631\u0627\u064b \u0644\u062f\u0649 \u0643\u0644\u0651\u064d \u0645\u0646 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a WHR <0.85 \u0648\u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0630\u0648\u0627\u062a WHR \u22650.85 \u0648\u0628\u0645\u0639\u062f\u0651\u0644 \u0628\u0642\u064a\u0627 \u0645\u062a\u0633\u0627\u0648\u064d \u0628\u0644\u063a 78.7% \u0644\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 (P=0.852).<\/span><\/p>\n

\"\"<\/span><\/p>\n

\"\u0627\u0644\u0634\u0643\u0644
\u0627\u0644\u0634\u0643\u0644 1: \u0645\u062e\u0637\u0637 \u0627\u0646\u0633\u064a\u0627\u0628\u064a \u062a\u0641\u0635\u064a\u0644\u064a\u0651 \u0644\u0645\u062c\u0631\u064a\u0627\u062a \u0627\u0646\u062a\u0642\u0627\u0621 \u062c\u0645\u0647\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/span><\/strong><\/figcaption><\/figure>\n
\"\u0627\u0644\u0634\u0651\u0643\u0644
\u0627\u0644\u0634\u0651\u0643\u0644 2: \u062a\u0642\u062f\u064a\u0631\u0627\u062a \u0643\u0627\u0628\u0644\u0627\u0646 \u0645\u0627\u064a\u0631 \u0644\u0644\u0628\u0642\u064a\u0627 \u0627\u0644\u0643\u0644\u064a\u0651\u0629 OS \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0646\u0642\u064a\u0644\u064a \u062e\u0644\u0627\u0644 \u0641\u062a\u0631\u0629 \u0645\u062a\u0627\u0628\u0639\u0629 \u0628\u0644\u063a\u062a 18 \u0634\u0647\u0631\u0627\u064b. (A) \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 BMI \u0628\u0642\u064a\u0645\u0629 \u062d\u062f\u064a\u0651\u0629=25 \u0643\u063a\/\u06452 (n=156). (B) \u0648\u0641\u0642\u0627\u064b \u0644\u0644\u062a\u0651\u0635\u0646\u064a\u0641\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062b \u0644\u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 BMI (n=156). (C) \u0648\u0641\u0642\u0627\u064b \u0644\u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 (WC) \u0628\u0642\u064a\u0645\u0629 \u062d\u062f\u064a\u0651\u0629=80 \u0633\u0645 (n=147). (D) \u0648\u0641\u0642\u0627\u064b \u0644\u0646\u0633\u0628\u0629 \u062f\u0647\u0648\u0646 \u0627\u0644\u062c\u0633\u0645 BF% \u0628\u0642\u064a\u0645\u0629 \u062d\u062f\u064a\u0651\u0629=35% (n=156).<\/span><\/strong><\/figcaption><\/figure>\n

\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 <\/strong>Discussion<\/strong><\/span><\/p>\n

\u064a\u064f\u0634\u062e\u0651\u0635 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0651\u0642\u064a\u0644\u064a MBC \u0644\u062f\u0649 \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 \u0645\u0646 30% \u0645\u0646 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a\u060c \u0648\u064a\u064f\u0639\u062f\u0651 \u0627\u0644\u0633\u0628\u0628 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0651 \u0644\u0644\u0648\u0641\u0627\u0629 \u0627\u0644\u0645\u062a\u0635\u0644\u0629 \u0628\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0644\u062f\u0649 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a. (12) \u0648\u064a\u062a\u0633\u0645 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u0646\u0651\u0642\u064a\u0644\u064a \u0628\u0643\u0648\u0646\u0647 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633 \u0648\u0630\u0627 \u0633\u0644\u0648\u0643\u064d \u0633\u0631\u064a\u0631\u064a\u0651 \u0644\u0627 \u064a\u0645\u0643\u0646 \u0627\u0644\u062a\u0646\u0628\u0624 \u0628\u0647 (5). \u062a\u0639\u0627\u0646\u064a \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0627\u0644\u0645\u0635\u0627\u0628\u0627\u062a \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u0645\u0646 \u0628\u0642\u064a\u0627 \u0642\u0635\u064a\u0631\u0629 \u0627\u0644\u0623\u0645\u062f (2)\u060c \u0648\u0644\u0647\u0630\u0627 \u064a\u0639\u062f\u0651 \u0627\u0644\u062a\u0646\u0628\u0624 \u0628\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0648\u0627\u0644\u0628\u0642\u064a\u0627 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0645\u062a\u0642\u062f\u0651\u0645\u0629 \u0630\u0627 \u0623\u0647\u0645\u064a\u0651\u0629 \u0643\u0628\u0631\u0649 \u062a\u064f\u0633\u0647\u0645 \u0641\u064a \u0639\u0645\u0644\u064a\u0651\u0629 \u0627\u062a\u0651\u062e\u0627\u0630 \u0627\u0644\u0642\u0631\u0627\u0631\u0627\u062a \u0627\u0644\u0633\u0651\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0648\u0627\u0644\u0631\u0651\u0639\u0627\u064a\u0629 \u0627\u0644\u062a\u0651\u0644\u0637\u064a\u0641\u064a\u0651\u0629 (13). <\/span>\u062f\u064f\u0631\u0633\u062a \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0629 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642\u064d \u0648\u0627\u0633\u0639\u064d \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0641\u064a \u0645\u0631\u0627\u062d\u0644\u0647 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 0\u060c I\u060c II\u060c \u0648\u0628\u0627\u0644\u0645\u0642\u0627\u0628\u0644 \u062a\u062a\u0633\u0645 \u0627\u0644\u062f\u0651\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0634\u0627\u0628\u0647\u0629 \u0641\u064a \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0651\u0642\u064a\u0644\u064a \u0628\u0627\u0644\u0646\u0651\u062f\u0631\u0629 (14). \u062a\u0639\u062f \u0627\u0644\u0628\u062f\u0627\u0646\u0629 obesity \u0623\u062d\u062f \u0623\u0647\u0645 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 (2)\u060c \u0648\u064a\u0639\u0628\u0651\u0631 \u0639\u0646\u0647\u0627 \u0628\u0639\u062f\u0651\u0629 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\u0627\u0644\u0639\u0643\u0633\u064a Reverse Epidemiology” \u0648\u0627\u0644\u0644\u0630\u064a\u0646 \u064a\u0642\u0648\u0645\u0627\u0646 \u0639\u0644\u0649 \u0623\u0646\u0651\u0647 \u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u0651\u063a\u0645 \u0645\u0646 \u0627\u0644\u062f\u0648\u0631 \u0627\u0644\u0643\u0628\u064a\u0631 \u0627\u0644\u0630\u064a \u064a\u064f\u0646\u0633\u0628 \u0644\u0644\u0628\u062f\u0627\u0646\u0629 \u0641\u064a \u062a\u0637\u0648\u0651\u0631 \u0639\u062f\u062f \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u062d\u0627\u062f\u0651\u0629 \u0648\u0627\u0644\u0645\u0632\u0645\u0646\u0629\u060c \u0625\u0644\u0627 \u0623\u0646\u0647\u0627 \u062a\u0645\u0646\u062d \u0628\u0642\u064a\u0627 \u0623\u0641\u0636\u0644 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0623\u0645\u0631\u0627\u0636 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0647\u0632\u0627\u0644 \u0648\u0645\u0646\u0647\u0627 \u0627\u0644\u0633\u0651\u0631\u0637\u0627\u0646 (29\u060c 30). \u0648\u0625\u062d\u062f\u0649 \u0627\u0644\u0646\u0651\u0638\u0631\u064a\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u062f\u0651\u0627\u0639\u0645\u0629 \u0647\u064a \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u0646\u0638\u0631 \u0644\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0634\u0651\u062d\u0645\u064a\u0651\u0629 \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u0628\u0648\u0635\u0641\u0647\u0627 \u0639\u0636\u0648\u0627\u064b \u0645\u0646\u0627\u0639\u064a\u0651\u0627\u064b \u064a\u0644\u0639\u0628 \u0628\u0622\u0644\u064a\u0651\u0629 \u0645\u062c\u0647\u0648\u0644\u0629 \u062f\u0648\u0631\u0627\u064b \u0647\u0627\u0645\u0651\u0627\u064b \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0651\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0651\u0629 \u0644\u0644\u0648\u0631\u0645\u060c \u062d\u064a\u062b \u0644\u0648\u062d\u0638\u062a \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0625\u0641\u0631\u0627\u0632 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0644\u064a\u0628\u062a\u064a\u0646 \u0645\u0646 \u0642\u0628\u0644 \u062a\u0644\u0643 \u0627\u0644\u0646\u0651\u0633\u062c\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0639\u0632\u0649 \u0644\u0647 \u062f\u0648\u0631 \u0645\u0647\u0645\u0651\u064c \u0641\u064a \u062a\u0639\u062f\u064a\u0644 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0651\u0627\u0626\u064a\u0629 \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0628\u062f\u0648\u0631\u0647 \u0625\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0648\u0627\u0644\u0628\u0642\u064a\u0627. \u0643\u0645\u0627 \u0630\u0643\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u0645\u0627 \u0642\u0628\u0644 \u0633\u0631\u064a\u0631\u064a\u0651\u0629 \u0623\u0646 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0634\u0651\u062d\u0645\u064a\u0651\u0629 \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u062a\u0639\u0645\u0644 \u0643\u0645\u064e\u062e\u0652\u0632\u064e\u0646 reservoir \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u062e\u0627\u0635\u0629 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0630\u0627\u0643\u0631\u0629 \u0627\u0644\u062a\u0627\u0626\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0642\u0648\u0645 \u0628\u0628\u0639\u0636 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0641\u0639\u0651\u0627\u0644\u0629 \u0641\u064a \u062d\u0627\u0644\u0629 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0639\u0631\u0651\u0636 \u0644\u0645\u0633\u062a\u0636\u062f \u0645\u0627\u060c \u0643\u0645\u0627 \u0647\u0648 \u0627\u0644\u062d\u0627\u0644 \u0639\u0646\u062f \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u0645\u0633\u062a\u0636\u062f\u0627\u062a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0633\u0651\u0631\u0637\u0627\u0646 (29).<\/span><\/p>\n

\u00a0<\/strong>\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a <\/strong>Conclusions<\/strong><\/span><\/p>\n

\u062a\u0644\u0642\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0651\u0627\u0631\u0633\u0629 \u0627\u0644\u0636\u0648\u0621 \u0639\u0644\u0649 \u0627\u0644\u0623\u0647\u0645\u064a\u0651\u0629 \u0627\u0644\u0625\u0646\u0630\u0627\u0631\u064a\u0651\u0629 \u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0648\u062a\u062f\u0639\u0645 \u0641\u0631\u0636\u064a\u0651\u0629 \u062a\u0631\u0627\u0641\u0642 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 obesity\u060c \u0645\u0642\u064a\u0651\u0645\u0629\u064b \u0628\u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0646\u0633\u0628 \u0643\u062a\u0644\u0629 \u0627\u0644\u062c\u0633\u0645 \u00a0BMI\u0648\/ \u0623\u0648 \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0648\/\u0623\u0648 \u0646\u0633\u0628\u0629 \u062f\u0647\u0648\u0646 \u0627\u0644\u062c\u0633\u0645\u060c \u0645\u0639 \u0628\u0642\u064a\u0627 \u0623\u0641\u0636\u0644 \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u0627\u0644\u0644\u0627\u062a\u064a \u064a\u062a\u0644\u0642\u064a\u0646 \u0645\u0639\u0627\u0644\u062c\u0629 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0651\u0629 \u062a\u0644\u0637\u064a\u0641\u064a\u0651\u0629. \u0648\u062a\u0642\u062a\u0631\u062d \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0639\u0645\u0651\u0642\u0629 \u062a\u0633\u062a\u0642\u0635\u064a \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0641\u064a \u0627\u0644\u0645\u062d\u0635\u0651\u0644\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0651\u0629 \u0648\u0627\u0644\u0628\u0642\u064a\u0627 \u0644\u062f\u0649 \u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u062b\u062f\u064a \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0627\u062d\u0644\u060c \u0648\u0625\u0631\u0641\u0627\u0642 \u0627\u0644\u0645\u062a\u062b\u0627\u0628\u062a\u0627\u062a \u0627\u0644\u0645\u062f\u0631\u0648\u0633\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0645\u0639 \u0645\u0642\u0627\u064a\u0633\u0627\u062a \u0645\u062e\u0628\u0631\u064a\u0651\u0629 \u0630\u0627\u062a \u0635\u0644\u0629 \u0648\u062b\u064a\u0642\u0629 (\u0645\u062b\u0644 \u0627\u0644\u0644\u064a\u0628\u062a\u064a\u0646 Leptin \u0648\u0627\u0644\u0623\u062f\u064a\u0628\u0648\u0646\u064a\u0643\u062a\u064a\u0646 Adiponectin) \u0642\u062f \u062a\u064f\u0633\u0647\u0645 \u0641\u064a \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0628\u062f\u0627\u0646\u0629 \u0628\u0635\u0648\u0631\u0629 \u0623\u0641\u0636\u0644.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0627\u0644\u0645\u0642\u062f\u0645\u0629 Introduction \u064a\u0639\u062f\u0651 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u0651\u062f\u064a \u0627\u0644\u062e\u0628\u0627\u062b\u0629 \u0627\u0644\u0623\u0634\u064a\u0639 \u0628\u064a\u0646 \u0627\u0644\u0646\u0651\u0633\u0627\u0621 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0648\u0627\u0644\u0645\u0633\u0628\u0651\u0628 \u0627\u0644\u062b\u0651\u0627\u0646\u064a \u0644\u0644\u0648\u0641\u0627\u0629 \u0628\u064a\u0646 \u0646\u0633\u0627\u0621 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0651\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0651\u0629\u061b (1\u060c 2) \u0648\u0639\u0644\u0649…
\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/a><\/p>\n","protected":false},"author":2,"featured_media":701,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[136],"tags":[],"class_list":["post-255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-136","issue-131","volume-8","year-138"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=255"}],"version-history":[{"count":0,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/posts\/255\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=\/wp\/v2\/media\/701"}],"wp:attachment":[{"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmjournal.asscph.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}